-- dump date   	20140619_232444
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
701521000001	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
701521000002	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
701521000003	DnaA N-terminal domain; Region: DnaA_N; pfam11638
701521000004	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
701521000005	Walker A motif; other site
701521000006	ATP binding site [chemical binding]; other site
701521000007	Walker B motif; other site
701521000008	arginine finger; other site
701521000009	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
701521000010	DnaA box-binding interface [nucleotide binding]; other site
701521000011	DNA polymerase III subunit beta; Validated; Region: PRK05643
701521000012	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
701521000013	putative DNA binding surface [nucleotide binding]; other site
701521000014	dimer interface [polypeptide binding]; other site
701521000015	beta-clamp/clamp loader binding surface; other site
701521000016	beta-clamp/translesion DNA polymerase binding surface; other site
701521000017	S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988
701521000018	recombination protein F; Reviewed; Region: recF; PRK00064
701521000019	ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242
701521000020	Walker A/P-loop; other site
701521000021	ATP binding site [chemical binding]; other site
701521000022	Q-loop/lid; other site
701521000023	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
701521000024	ABC transporter signature motif; other site
701521000025	Walker B; other site
701521000026	D-loop; other site
701521000027	H-loop/switch region; other site
701521000028	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
701521000029	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
701521000030	Mg2+ binding site [ion binding]; other site
701521000031	G-X-G motif; other site
701521000032	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
701521000033	anchoring element; other site
701521000034	dimer interface [polypeptide binding]; other site
701521000035	ATP binding site [chemical binding]; other site
701521000036	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
701521000037	active site
701521000038	metal binding site [ion binding]; metal-binding site
701521000039	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
701521000040	DNA gyrase subunit A; Validated; Region: PRK05560
701521000041	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
701521000042	CAP-like domain; other site
701521000043	active site
701521000044	primary dimer interface [polypeptide binding]; other site
701521000045	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
701521000046	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
701521000047	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
701521000048	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
701521000049	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
701521000050	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
701521000051	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
701521000052	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
701521000053	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
701521000054	dimer interface [polypeptide binding]; other site
701521000055	ssDNA binding site [nucleotide binding]; other site
701521000056	tetramer (dimer of dimers) interface [polypeptide binding]; other site
701521000057	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
701521000058	Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887
701521000059	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
701521000060	DHH family; Region: DHH; pfam01368
701521000061	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
701521000062	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
701521000063	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
701521000064	replicative DNA helicase; Provisional; Region: PRK05748
701521000065	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
701521000066	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
701521000067	Walker A motif; other site
701521000068	ATP binding site [chemical binding]; other site
701521000069	Walker B motif; other site
701521000070	DNA binding loops [nucleotide binding]
701521000071	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
701521000072	Major Facilitator Superfamily; Region: MFS_1; pfam07690
701521000073	putative substrate translocation pore; other site
701521000074	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
701521000075	NlpC/P60 family; Region: NLPC_P60; pfam00877
701521000076	Protein of unknown function (DUF1304); Region: DUF1304; pfam06993
701521000077	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
701521000078	active site
701521000079	Fe-S cluster binding site [ion binding]; other site
701521000080	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
701521000081	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539
701521000082	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
701521000083	EAL domain; Region: EAL; pfam00563
701521000084	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
701521000085	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
701521000086	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
701521000087	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
701521000088	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
701521000089	metal binding site [ion binding]; metal-binding site
701521000090	active site
701521000091	I-site; other site
701521000092	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
701521000093	putative uracil binding site [chemical binding]; other site
701521000094	putative active site [active]
701521000095	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4152
701521000096	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
701521000097	Walker A/P-loop; other site
701521000098	ATP binding site [chemical binding]; other site
701521000099	Q-loop/lid; other site
701521000100	ABC transporter signature motif; other site
701521000101	Walker B; other site
701521000102	D-loop; other site
701521000103	H-loop/switch region; other site
701521000104	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
701521000105	ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668
701521000106	FAD binding domain; Region: FAD_binding_4; pfam01565
701521000107	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
701521000108	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
701521000109	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
701521000110	Protein of unknown function (DUF419); Region: DUF419; cl15265
701521000111	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204
701521000112	PLD-like domain; Region: PLDc_2; pfam13091
701521000113	putative homodimer interface [polypeptide binding]; other site
701521000114	putative active site [active]
701521000115	catalytic site [active]
701521000116	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
701521000117	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
701521000118	ATP binding site [chemical binding]; other site
701521000119	putative Mg++ binding site [ion binding]; other site
701521000120	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
701521000121	nucleotide binding region [chemical binding]; other site
701521000122	ATP-binding site [chemical binding]; other site
701521000123	Domain of unknown function (DUF3427); Region: DUF3427; pfam11907
701521000124	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
701521000125	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
701521000126	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
701521000127	active pocket/dimerization site; other site
701521000128	active site
701521000129	phosphorylation site [posttranslational modification]
701521000130	PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830
701521000131	active site
701521000132	phosphorylation site [posttranslational modification]
701521000133	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
701521000134	PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613
701521000135	putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815
701521000136	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
701521000137	dimer interface [polypeptide binding]; other site
701521000138	active site
701521000139	AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010
701521000140	putative active site [active]
701521000141	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
701521000142	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
701521000143	active site
701521000144	dimer interface [polypeptide binding]; other site
701521000145	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
701521000146	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
701521000147	motif II; other site
701521000148	tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399
701521000149	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
701521000150	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
701521000151	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
701521000152	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
701521000153	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
701521000154	Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440
701521000155	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
701521000156	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
701521000157	catalytic residues [active]
701521000158	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
701521000159	NADH(P)-binding; Region: NAD_binding_10; pfam13460
701521000160	NAD(P) binding site [chemical binding]; other site
701521000161	putative active site [active]
701521000162	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
701521000163	NADH(P)-binding; Region: NAD_binding_10; pfam13460
701521000164	NAD(P) binding site [chemical binding]; other site
701521000165	active site
701521000166	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
701521000167	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
701521000168	NAD(P) binding site [chemical binding]; other site
701521000169	active site
701521000170	dipeptidase PepV; Reviewed; Region: PRK07318
701521000171	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
701521000172	active site
701521000173	metal binding site [ion binding]; metal-binding site
701521000174	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
701521000175	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
701521000176	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
701521000177	tyrosyl-tRNA synthetase; Provisional; Region: PRK13354
701521000178	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
701521000179	active site
701521000180	HIGH motif; other site
701521000181	dimer interface [polypeptide binding]; other site
701521000182	KMSKS motif; other site
701521000183	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
701521000184	RNA binding surface [nucleotide binding]; other site
701521000185	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
701521000186	Major Facilitator Superfamily; Region: MFS_1; pfam07690
701521000187	putative substrate translocation pore; other site
701521000188	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
701521000189	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
701521000190	Coenzyme A binding pocket [chemical binding]; other site
701521000191	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
701521000192	Na binding site [ion binding]; other site
701521000193	cytosine deaminase; Provisional; Region: PRK09230
701521000194	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
701521000195	active site
701521000196	alcohol dehydrogenase; Provisional; Region: PTZ00354
701521000197	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
701521000198	putative NAD(P) binding site [chemical binding]; other site
701521000199	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
701521000200	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
701521000201	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
701521000202	putative DNA binding site [nucleotide binding]; other site
701521000203	putative Zn2+ binding site [ion binding]; other site
701521000204	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
701521000205	dimer interface [polypeptide binding]; other site
701521000206	conserved gate region; other site
701521000207	ABC-ATPase subunit interface; other site
701521000208	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
701521000209	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
701521000210	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
701521000211	Walker A/P-loop; other site
701521000212	ATP binding site [chemical binding]; other site
701521000213	Q-loop/lid; other site
701521000214	ABC transporter signature motif; other site
701521000215	Walker B; other site
701521000216	D-loop; other site
701521000217	H-loop/switch region; other site
701521000218	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
701521000219	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
701521000220	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
701521000221	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
701521000222	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
701521000223	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
701521000224	hypothetical protein; Provisional; Region: PRK06762
701521000225	pyruvate carboxylase; Reviewed; Region: PRK12999
701521000226	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
701521000227	ATP-grasp domain; Region: ATP-grasp_4; cl17255
701521000228	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
701521000229	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
701521000230	active site
701521000231	catalytic residues [active]
701521000232	metal binding site [ion binding]; metal-binding site
701521000233	homodimer binding site [polypeptide binding]; other site
701521000234	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
701521000235	carboxyltransferase (CT) interaction site; other site
701521000236	biotinylation site [posttranslational modification]; other site
701521000237	aspartate aminotransferase; Provisional; Region: PRK05764
701521000238	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
701521000239	pyridoxal 5'-phosphate binding site [chemical binding]; other site
701521000240	homodimer interface [polypeptide binding]; other site
701521000241	catalytic residue [active]
701521000242	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
701521000243	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
701521000244	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
701521000245	Part of AAA domain; Region: AAA_19; pfam13245
701521000246	Family description; Region: UvrD_C_2; pfam13538
701521000247	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
701521000248	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
701521000249	active site
701521000250	HIGH motif; other site
701521000251	dimer interface [polypeptide binding]; other site
701521000252	KMSKS motif; other site
701521000253	Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657
701521000254	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
701521000255	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
701521000256	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
701521000257	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
701521000258	NAD(P) binding site [chemical binding]; other site
701521000259	active site
701521000260	exopolyphosphatase; Region: exo_poly_only; TIGR03706
701521000261	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
701521000262	Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644
701521000263	homodimer interface [polypeptide binding]; other site
701521000264	catalytic residues [active]
701521000265	NAD binding site [chemical binding]; other site
701521000266	substrate binding pocket [chemical binding]; other site
701521000267	flexible flap; other site
701521000268	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
701521000269	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
701521000270	peptide binding site [polypeptide binding]; other site
701521000271	Putative stress-responsive transcriptional regulator [Transcription / Signal transduction mechanisms]; Region: PspC; COG1983
701521000272	Protein of unknown function DUF72; Region: DUF72; pfam01904
701521000273	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
701521000274	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
701521000275	HIGH motif; other site
701521000276	active site
701521000277	KMSKS motif; other site
701521000278	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
701521000279	tRNA binding surface [nucleotide binding]; other site
701521000280	anticodon binding site; other site
701521000281	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
701521000282	dimer interface [polypeptide binding]; other site
701521000283	putative tRNA-binding site [nucleotide binding]; other site
701521000284	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
701521000285	active site
701521000286	ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334
701521000287	TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea.  RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027
701521000288	putative active site [active]
701521000289	putative metal binding site [ion binding]; other site
701521000290	Domain of unknown function (DUF4093); Region: DUF4093; pfam13331
701521000291	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
701521000292	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
701521000293	S-adenosylmethionine binding site [chemical binding]; other site
701521000294	Protein of unknown function (DUF1021); Region: DUF1021; pfam06257
701521000295	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
701521000296	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
701521000297	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
701521000298	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
701521000299	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
701521000300	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
701521000301	Ligand Binding Site [chemical binding]; other site
701521000302	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
701521000303	Ligand Binding Site [chemical binding]; other site
701521000304	Cytochrome b5-like Heme/Steroid binding domain; Region: Cyt-b5; cl02041
701521000305	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
701521000306	RelB antitoxin; Region: RelB; cl01171
701521000307	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
701521000308	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
701521000309	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
701521000310	dimer interface [polypeptide binding]; other site
701521000311	active site
701521000312	CoA binding pocket [chemical binding]; other site
701521000313	acyl carrier protein; Provisional; Region: acpP; PRK00982
701521000314	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
701521000315	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
701521000316	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
701521000317	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
701521000318	NAD(P) binding site [chemical binding]; other site
701521000319	homotetramer interface [polypeptide binding]; other site
701521000320	homodimer interface [polypeptide binding]; other site
701521000321	active site
701521000322	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
701521000323	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
701521000324	dimer interface [polypeptide binding]; other site
701521000325	active site
701521000326	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
701521000327	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
701521000328	carboxyltransferase (CT) interaction site; other site
701521000329	biotinylation site [posttranslational modification]; other site
701521000330	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
701521000331	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
701521000332	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
701521000333	ATP-grasp domain; Region: ATP-grasp_4; cl17255
701521000334	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
701521000335	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
701521000336	Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
701521000337	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
701521000338	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
701521000339	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06079
701521000340	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
701521000341	NAD binding site [chemical binding]; other site
701521000342	homotetramer interface [polypeptide binding]; other site
701521000343	homodimer interface [polypeptide binding]; other site
701521000344	substrate binding site [chemical binding]; other site
701521000345	active site
701521000346	Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091
701521000347	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
701521000348	BioY family; Region: BioY; pfam02632
701521000349	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
701521000350	Double zinc ribbon; Region: DZR; pfam12773
701521000351	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
701521000352	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
701521000353	Double zinc ribbon; Region: DZR; pfam12773
701521000354	Predicted membrane protein [Function unknown]; Region: COG4640
701521000355	D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine  to pyruvate and ammonia.  D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447
701521000356	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
701521000357	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
701521000358	catalytic residue [active]
701521000359	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
701521000360	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
701521000361	Walker A/P-loop; other site
701521000362	ATP binding site [chemical binding]; other site
701521000363	Q-loop/lid; other site
701521000364	ABC transporter signature motif; other site
701521000365	Walker B; other site
701521000366	D-loop; other site
701521000367	H-loop/switch region; other site
701521000368	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
701521000369	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
701521000370	TM-ABC transporter signature motif; other site
701521000371	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
701521000372	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
701521000373	zinc binding site [ion binding]; other site
701521000374	putative ligand binding site [chemical binding]; other site
701521000375	Protein of unknown function (DUF1211); Region: DUF1211; cl01421
701521000376	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
701521000377	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
701521000378	Coenzyme A binding pocket [chemical binding]; other site
701521000379	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
701521000380	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
701521000381	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
701521000382	DXD motif; other site
701521000383	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
701521000384	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
701521000385	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
701521000386	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
701521000387	DNA-binding site [nucleotide binding]; DNA binding site
701521000388	UTRA domain; Region: UTRA; pfam07702
701521000389	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
701521000390	active site
701521000391	P-loop; other site
701521000392	phosphorylation site [posttranslational modification]
701521000393	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
701521000394	active site
701521000395	methionine cluster; other site
701521000396	phosphorylation site [posttranslational modification]
701521000397	metal binding site [ion binding]; metal-binding site
701521000398	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
701521000399	beta-galactosidase; Region: BGL; TIGR03356
701521000400	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
701521000401	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
701521000402	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
701521000403	putative active site [active]
701521000404	hypothetical protein; Provisional; Region: PRK13685
701521000405	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
701521000406	metal ion-dependent adhesion site (MIDAS); other site
701521000407	Cna protein B-type domain; Region: Cna_B; pfam05738
701521000408	Cna protein B-type domain; Region: Cna_B; pfam05738
701521000409	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
701521000410	domain interaction interfaces [polypeptide binding]; other site
701521000411	Cna protein B-type domain; Region: Cna_B; pfam05738
701521000412	Cna protein B-type domain; Region: Cna_B; pfam05738
701521000413	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
701521000414	domain interaction interfaces [polypeptide binding]; other site
701521000415	Cna protein B-type domain; Region: Cna_B; pfam05738
701521000416	Cna protein B-type domain; Region: Cna_B; pfam05738
701521000417	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
701521000418	domain interaction interfaces [polypeptide binding]; other site
701521000419	Cna protein B-type domain; Region: Cna_B; pfam05738
701521000420	Cna protein B-type domain; Region: Cna_B; pfam05738
701521000421	Sortases are cysteine transpeptidases, found in gram-positive bacteria, that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the surface protein substrate is...; Region: Sortase; cl09098
701521000422	active site
701521000423	catalytic site [active]
701521000424	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
701521000425	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
701521000426	aromatic amino acid aminotransferase; Validated; Region: PRK07309
701521000427	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
701521000428	pyridoxal 5'-phosphate binding site [chemical binding]; other site
701521000429	homodimer interface [polypeptide binding]; other site
701521000430	catalytic residue [active]
701521000431	dihydrodipicolinate reductase; Provisional; Region: PRK00048
701521000432	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
701521000433	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
701521000434	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
701521000435	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
701521000436	dimer interface [polypeptide binding]; other site
701521000437	active site
701521000438	catalytic residue [active]
701521000439	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
701521000440	M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670
701521000441	metal binding site [ion binding]; metal-binding site
701521000442	putative dimer interface [polypeptide binding]; other site
701521000443	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
701521000444	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
701521000445	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
701521000446	active site
701521000447	trimer interface [polypeptide binding]; other site
701521000448	substrate binding site [chemical binding]; other site
701521000449	CoA binding site [chemical binding]; other site
701521000450	diaminopimelate decarboxylase; Region: lysA; TIGR01048
701521000451	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
701521000452	active site
701521000453	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
701521000454	substrate binding site [chemical binding]; other site
701521000455	catalytic residues [active]
701521000456	dimer interface [polypeptide binding]; other site
701521000457	aspartate kinase; Reviewed; Region: PRK09034
701521000458	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
701521000459	nucleotide binding site [chemical binding]; other site
701521000460	substrate binding site [chemical binding]; other site
701521000461	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911
701521000462	allosteric regulatory residue; other site
701521000463	ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916
701521000464	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
701521000465	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
701521000466	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
701521000467	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
701521000468	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
701521000469	DXD motif; other site
701521000470	Predicted outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG4932
701521000471	Mga helix-turn-helix domain; Region: Mga; pfam05043
701521000472	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
701521000473	Sterol carrier protein domain; Region: SCP2_2; pfam13530
701521000474	Metal binding protein TroA_b.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020
701521000475	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
701521000476	metal binding site [ion binding]; metal-binding site
701521000477	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
701521000478	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
701521000479	Walker A/P-loop; other site
701521000480	ATP binding site [chemical binding]; other site
701521000481	Q-loop/lid; other site
701521000482	ABC transporter signature motif; other site
701521000483	Walker B; other site
701521000484	D-loop; other site
701521000485	H-loop/switch region; other site
701521000486	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
701521000487	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
701521000488	ABC-ATPase subunit  interface; other site
701521000489	dimer interface [polypeptide binding]; other site
701521000490	putative PBP binding regions; other site
701521000491	pur operon repressor; Provisional; Region: PRK09213
701521000492	Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182
701521000493	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
701521000494	active site
701521000495	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
701521000496	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
701521000497	Substrate binding site; other site
701521000498	Mg++ binding site; other site
701521000499	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
701521000500	active site
701521000501	substrate binding site [chemical binding]; other site
701521000502	CoA binding site [chemical binding]; other site
701521000503	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
701521000504	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
701521000505	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
701521000506	active site
701521000507	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
701521000508	aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227
701521000509	NADP binding site [chemical binding]; other site
701521000510	putative substrate binding site [chemical binding]; other site
701521000511	active site
701521000512	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
701521000513	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
701521000514	DNA binding residues [nucleotide binding]
701521000515	putative dimer interface [polypeptide binding]; other site
701521000516	Uncharacterized protein conserved in bacteria (DUF2316); Region: DUF2316; cl01805
701521000517	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
701521000518	amphipathic channel; other site
701521000519	Asn-Pro-Ala signature motifs; other site
701521000520	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
701521000521	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
701521000522	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
701521000523	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
701521000524	active site
701521000525	motif I; other site
701521000526	motif II; other site
701521000527	Membrane transport protein; Region: Mem_trans; pfam03547
701521000528	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
701521000529	active site
701521000530	zinc binding site [ion binding]; other site
701521000531	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
701521000532	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
701521000533	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
701521000534	FMN binding site [chemical binding]; other site
701521000535	dimer interface [polypeptide binding]; other site
701521000536	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
701521000537	inhibitor site; inhibition site
701521000538	active site
701521000539	dimer interface [polypeptide binding]; other site
701521000540	catalytic residue [active]
701521000541	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
701521000542	Coenzyme A binding pocket [chemical binding]; other site
701521000543	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
701521000544	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
701521000545	putative substrate translocation pore; other site
701521000546	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
701521000547	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
701521000548	Major Facilitator Superfamily; Region: MFS_1; pfam07690
701521000549	putative substrate translocation pore; other site
701521000550	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
701521000551	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
701521000552	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458
701521000553	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
701521000554	active site
701521000555	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
701521000556	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
701521000557	putative substrate translocation pore; other site
701521000558	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
701521000559	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
701521000560	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
701521000561	DNA binding residues [nucleotide binding]
701521000562	putative dimer interface [polypeptide binding]; other site
701521000563	Predicted membrane protein [Function unknown]; Region: COG3601
701521000564	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
701521000565	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
701521000566	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
701521000567	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
701521000568	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
701521000569	acyl-activating enzyme (AAE) consensus motif; other site
701521000570	AMP binding site [chemical binding]; other site
701521000571	D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091
701521000572	D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087
701521000573	D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092
701521000574	DltD N-terminal region; Region: DltD_N; pfam04915
701521000575	DltD central region; Region: DltD_M; pfam04918
701521000576	DltD C-terminal region; Region: DltD_C; pfam04914
701521000577	Uncharacterized conserved protein [Function unknown]; Region: COG1284
701521000578	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
701521000579	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
701521000580	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
701521000581	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
701521000582	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
701521000583	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
701521000584	Predicted membrane protein [Function unknown]; Region: COG4684
701521000585	FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454
701521000586	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
701521000587	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
701521000588	motif II; other site
701521000589	CAAX protease self-immunity; Region: Abi; pfam02517
701521000590	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
701521000591	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138
701521000592	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
701521000593	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
701521000594	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
701521000595	putative Zn2+ binding site [ion binding]; other site
701521000596	putative DNA binding site [nucleotide binding]; other site
701521000597	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
701521000598	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
701521000599	Zn2+ binding site [ion binding]; other site
701521000600	Mg2+ binding site [ion binding]; other site
701521000601	Domain of unknown function (DUF1934); Region: DUF1934; pfam09148
701521000602	DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066
701521000603	CTP synthetase; Validated; Region: pyrG; PRK05380
701521000604	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
701521000605	Catalytic site [active]
701521000606	active site
701521000607	UTP binding site [chemical binding]; other site
701521000608	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
701521000609	active site
701521000610	putative oxyanion hole; other site
701521000611	catalytic triad [active]
701521000612	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
701521000613	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
701521000614	hinge; other site
701521000615	active site
701521000616	transcription termination factor Rho; Provisional; Region: rho; PRK09376
701521000617	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
701521000618	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
701521000619	RNA binding site [nucleotide binding]; other site
701521000620	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
701521000621	Walker A motif; other site
701521000622	ATP binding site [chemical binding]; other site
701521000623	Walker B motif; other site
701521000624	50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678
701521000625	drug efflux system protein MdtG; Provisional; Region: PRK09874
701521000626	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
701521000627	putative substrate translocation pore; other site
701521000628	Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165
701521000629	active site
701521000630	catalytic site [active]
701521000631	Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704
701521000632	heat shock protein HtpX; Provisional; Region: PRK04897
701521000633	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
701521000634	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
701521000635	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
701521000636	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
701521000637	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
701521000638	DEAD-like helicases superfamily; Region: DEXDc; smart00487
701521000639	ATP binding site [chemical binding]; other site
701521000640	Mg++ binding site [ion binding]; other site
701521000641	motif III; other site
701521000642	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
701521000643	nucleotide binding region [chemical binding]; other site
701521000644	ATP-binding site [chemical binding]; other site
701521000645	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
701521000646	alanine racemase; Reviewed; Region: alr; PRK00053
701521000647	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
701521000648	active site
701521000649	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
701521000650	dimer interface [polypeptide binding]; other site
701521000651	substrate binding site [chemical binding]; other site
701521000652	catalytic residues [active]
701521000653	PemK-like protein; Region: PemK; pfam02452
701521000654	QueT transporter; Region: QueT; pfam06177
701521000655	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
701521000656	FOG: CBS domain [General function prediction only]; Region: COG0517
701521000657	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
701521000658	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
701521000659	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
701521000660	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
701521000661	tetramer (dimer of dimers) interface [polypeptide binding]; other site
701521000662	NAD binding site [chemical binding]; other site
701521000663	dimer interface [polypeptide binding]; other site
701521000664	substrate binding site [chemical binding]; other site
701521000665	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
701521000666	Pyruvate formate lyase 1; Region: PFL1; cd01678
701521000667	coenzyme A binding site [chemical binding]; other site
701521000668	active site
701521000669	catalytic residues [active]
701521000670	glycine loop; other site
701521000671	pyruvate formate-lyase 1-activating enzyme; Region: PFLA; TIGR02493
701521000672	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
701521000673	FeS/SAM binding site; other site
701521000674	CCC1-related family of proteins; Region: CCC1_like; cl00278
701521000675	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
701521000676	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
701521000677	Walker A/P-loop; other site
701521000678	ATP binding site [chemical binding]; other site
701521000679	Q-loop/lid; other site
701521000680	ABC transporter signature motif; other site
701521000681	Walker B; other site
701521000682	D-loop; other site
701521000683	H-loop/switch region; other site
701521000684	Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719
701521000685	FeS assembly protein SufD; Region: sufD; TIGR01981
701521000686	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
701521000687	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
701521000688	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
701521000689	catalytic residue [active]
701521000690	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
701521000691	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
701521000692	trimerization site [polypeptide binding]; other site
701521000693	active site
701521000694	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
701521000695	FeS assembly protein SufB; Region: sufB; TIGR01980
701521000696	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
701521000697	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
701521000698	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
701521000699	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
701521000700	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
701521000701	Malic enzyme, N-terminal domain; Region: malic; pfam00390
701521000702	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
701521000703	putative NAD(P) binding site [chemical binding]; other site
701521000704	Membrane transport protein; Region: Mem_trans; pfam03547
701521000705	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
701521000706	Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053
701521000707	active site
701521000708	nucleotide binding site [chemical binding]; other site
701521000709	HIGH motif; other site
701521000710	KMSKS motif; other site
701521000711	citrate lyase subunit gamma; Provisional; Region: PRK13253
701521000712	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
701521000713	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
701521000714	Coenzyme A transferase; Region: CoA_trans; cl17247
701521000715	Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase; Region: CitX; pfam03802
701521000716	ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; cl00768
701521000717	glycogen branching enzyme; Provisional; Region: PRK12313
701521000718	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
701521000719	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
701521000720	active site
701521000721	catalytic site [active]
701521000722	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
701521000723	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
701521000724	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
701521000725	ligand binding site; other site
701521000726	oligomer interface; other site
701521000727	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
701521000728	dimer interface [polypeptide binding]; other site
701521000729	N-terminal domain interface [polypeptide binding]; other site
701521000730	sulfate 1 binding site; other site
701521000731	glucose-1-phosphate adenylyltransferase, GlgD subunit; Region: glgD; TIGR02092
701521000732	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
701521000733	ligand binding site; other site
701521000734	oligomer interface; other site
701521000735	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
701521000736	dimer interface [polypeptide binding]; other site
701521000737	N-terminal domain interface [polypeptide binding]; other site
701521000738	sulfate 1 binding site; other site
701521000739	glycogen synthase; Provisional; Region: glgA; PRK00654
701521000740	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
701521000741	ADP-binding pocket [chemical binding]; other site
701521000742	homodimer interface [polypeptide binding]; other site
701521000743	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
701521000744	homodimer interface [polypeptide binding]; other site
701521000745	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
701521000746	active site pocket [active]
701521000747	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
701521000748	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
701521000749	active site
701521000750	homodimer interface [polypeptide binding]; other site
701521000751	catalytic site [active]
701521000752	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
701521000753	putative active site [active]
701521000754	catalytic residue [active]
701521000755	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
701521000756	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
701521000757	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
701521000758	ATP binding site [chemical binding]; other site
701521000759	putative Mg++ binding site [ion binding]; other site
701521000760	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
701521000761	nucleotide binding region [chemical binding]; other site
701521000762	ATP-binding site [chemical binding]; other site
701521000763	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
701521000764	stage V sporulation protein B; Region: spore_V_B; TIGR02900
701521000765	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
701521000766	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
701521000767	RNA binding surface [nucleotide binding]; other site
701521000768	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
701521000769	Septum formation initiator; Region: DivIC; pfam04977
701521000770	hypothetical protein; Provisional; Region: PRK08582
701521000771	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
701521000772	RNA binding site [nucleotide binding]; other site
701521000773	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
701521000774	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
701521000775	Ligand Binding Site [chemical binding]; other site
701521000776	TilS substrate C-terminal domain; Region: TilS_C; smart00977
701521000777	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
701521000778	active site
701521000779	FtsH Extracellular; Region: FtsH_ext; pfam06480
701521000780	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
701521000781	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
701521000782	Walker A motif; other site
701521000783	ATP binding site [chemical binding]; other site
701521000784	Walker B motif; other site
701521000785	arginine finger; other site
701521000786	Peptidase family M41; Region: Peptidase_M41; pfam01434
701521000787	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
701521000788	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
701521000789	dimerization interface [polypeptide binding]; other site
701521000790	domain crossover interface; other site
701521000791	redox-dependent activation switch; other site
701521000792	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
701521000793	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
701521000794	FMN binding site [chemical binding]; other site
701521000795	active site
701521000796	catalytic residues [active]
701521000797	substrate binding site [chemical binding]; other site
701521000798	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
701521000799	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
701521000800	dimer interface [polypeptide binding]; other site
701521000801	putative anticodon binding site; other site
701521000802	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
701521000803	motif 1; other site
701521000804	active site
701521000805	motif 2; other site
701521000806	motif 3; other site
701521000807	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
701521000808	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
701521000809	putative substrate translocation pore; other site
701521000810	POT family; Region: PTR2; cl17359
701521000811	putative phosphoesterase; Region: acc_ester; TIGR03729
701521000812	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
701521000813	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
701521000814	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
701521000815	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
701521000816	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
701521000817	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
701521000818	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
701521000819	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
701521000820	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
701521000821	Phosphotransferase enzyme family; Region: APH; pfam01636
701521000822	active site
701521000823	ATP binding site [chemical binding]; other site
701521000824	Major Facilitator Superfamily; Region: MFS_1; pfam07690
701521000825	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
701521000826	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
701521000827	MarR family; Region: MarR; pfam01047
701521000828	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
701521000829	K+ potassium transporter; Region: K_trans; pfam02705
701521000830	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
701521000831	Coenzyme A binding pocket [chemical binding]; other site
701521000832	Cadmium resistance transporter; Region: Cad; pfam03596
701521000833	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
701521000834	dimerization interface [polypeptide binding]; other site
701521000835	putative DNA binding site [nucleotide binding]; other site
701521000836	putative Zn2+ binding site [ion binding]; other site
701521000837	Enterocin A Immunity; Region: EntA_Immun; pfam08951
701521000838	methionine sulfoxide reductase A; Provisional; Region: PRK14054
701521000839	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
701521000840	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
701521000841	THF binding site; other site
701521000842	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
701521000843	substrate binding site [chemical binding]; other site
701521000844	THF binding site; other site
701521000845	zinc-binding site [ion binding]; other site
701521000846	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
701521000847	FAD binding site [chemical binding]; other site
701521000848	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
701521000849	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
701521000850	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
701521000851	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
701521000852	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
701521000853	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
701521000854	active site
701521000855	dimer interface [polypeptide binding]; other site
701521000856	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
701521000857	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
701521000858	DNA-binding site [nucleotide binding]; DNA binding site
701521000859	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
701521000860	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
701521000861	Ligand Binding Site [chemical binding]; other site
701521000862	manganese transport protein MntH; Reviewed; Region: PRK00701
701521000863	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
701521000864	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
701521000865	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
701521000866	ATP binding site [chemical binding]; other site
701521000867	Mg2+ binding site [ion binding]; other site
701521000868	G-X-G motif; other site
701521000869	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
701521000870	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
701521000871	active site
701521000872	phosphorylation site [posttranslational modification]
701521000873	intermolecular recognition site; other site
701521000874	dimerization interface [polypeptide binding]; other site
701521000875	LytTr DNA-binding domain; Region: LytTR; pfam04397
701521000876	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
701521000877	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
701521000878	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
701521000879	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
701521000880	active site
701521000881	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
701521000882	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
701521000883	homodimer interface [polypeptide binding]; other site
701521000884	NAD binding pocket [chemical binding]; other site
701521000885	ATP binding pocket [chemical binding]; other site
701521000886	Mg binding site [ion binding]; other site
701521000887	active-site loop [active]
701521000888	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
701521000889	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
701521000890	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
701521000891	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
701521000892	Soluble P-type ATPase [General function prediction only]; Region: COG4087
701521000893	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
701521000894	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
701521000895	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
701521000896	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
701521000897	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
701521000898	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
701521000899	motif II; other site
701521000900	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
701521000901	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
701521000902	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
701521000903	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
701521000904	UbiA prenyltransferase family; Region: UbiA; pfam01040
701521000905	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
701521000906	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
701521000907	substrate binding pocket [chemical binding]; other site
701521000908	chain length determination region; other site
701521000909	substrate-Mg2+ binding site; other site
701521000910	catalytic residues [active]
701521000911	aspartate-rich region 1; other site
701521000912	active site lid residues [active]
701521000913	aspartate-rich region 2; other site
701521000914	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
701521000915	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
701521000916	ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247
701521000917	Walker A/P-loop; other site
701521000918	ATP binding site [chemical binding]; other site
701521000919	Q-loop/lid; other site
701521000920	ABC transporter signature motif; other site
701521000921	Walker B; other site
701521000922	D-loop; other site
701521000923	H-loop/switch region; other site
701521000924	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
701521000925	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
701521000926	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
701521000927	Walker A/P-loop; other site
701521000928	ATP binding site [chemical binding]; other site
701521000929	Q-loop/lid; other site
701521000930	ABC transporter signature motif; other site
701521000931	Walker B; other site
701521000932	D-loop; other site
701521000933	H-loop/switch region; other site
701521000934	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
701521000935	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
701521000936	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
701521000937	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
701521000938	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
701521000939	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
701521000940	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
701521000941	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
701521000942	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
701521000943	RNA binding site [nucleotide binding]; other site
701521000944	hypothetical protein; Provisional; Region: PRK04351
701521000945	SprT homologues; Region: SprT; cl01182
701521000946	Major Facilitator Superfamily; Region: MFS_1; pfam07690
701521000947	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
701521000948	putative substrate translocation pore; other site
701521000949	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
701521000950	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
701521000951	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
701521000952	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
701521000953	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
701521000954	putative substrate translocation pore; other site
701521000955	Predicted transcriptional regulators [Transcription]; Region: COG1733
701521000956	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
701521000957	Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973
701521000958	PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088
701521000959	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
701521000960	active pocket/dimerization site; other site
701521000961	active site
701521000962	phosphorylation site [posttranslational modification]
701521000963	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
701521000964	active site
701521000965	phosphorylation site [posttranslational modification]
701521000966	PTS system sorbose-specific iic component; Region: EII-Sor; cl01506
701521000967	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
701521000968	Domain of unknown function (DUF956); Region: DUF956; pfam06115
701521000969	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
701521000970	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
701521000971	Walker A motif; other site
701521000972	ATP binding site [chemical binding]; other site
701521000973	Walker B motif; other site
701521000974	arginine finger; other site
701521000975	Transcriptional antiterminator [Transcription]; Region: COG3933
701521000976	PRD domain; Region: PRD; pfam00874
701521000977	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
701521000978	active pocket/dimerization site; other site
701521000979	active site
701521000980	phosphorylation site [posttranslational modification]
701521000981	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
701521000982	active pocket/dimerization site; other site
701521000983	active site
701521000984	phosphorylation site [posttranslational modification]
701521000985	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
701521000986	active site
701521000987	phosphorylation site [posttranslational modification]
701521000988	Enterocin A Immunity; Region: EntA_Immun; pfam08951
701521000989	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
701521000990	HlyD family secretion protein; Region: HlyD_3; pfam13437
701521000991	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
701521000992	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
701521000993	active site
701521000994	phosphorylation site [posttranslational modification]
701521000995	intermolecular recognition site; other site
701521000996	dimerization interface [polypeptide binding]; other site
701521000997	LytTr DNA-binding domain; Region: LytTR; pfam04397
701521000998	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
701521000999	CAAX protease self-immunity; Region: Abi; pfam02517
701521001000	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
701521001001	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
701521001002	dimer interface [polypeptide binding]; other site
701521001003	active site
701521001004	CoA binding pocket [chemical binding]; other site
701521001005	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
701521001006	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
701521001007	carboxyltransferase (CT) interaction site; other site
701521001008	biotinylation site [posttranslational modification]; other site
701521001009	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
701521001010	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
701521001011	ATP-grasp domain; Region: ATP-grasp_4; cl17255
701521001012	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
701521001013	DNA directed RNA polymerase, 7 kDa subunit; Region: DNA_RNApol_7kD; cl00874
701521001014	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
701521001015	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
701521001016	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
701521001017	catalytic core [active]
701521001018	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
701521001019	Protein of unknown function (DUF1516); Region: DUF1516; pfam07457
701521001020	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
701521001021	trimer interface [polypeptide binding]; other site
701521001022	active site
701521001023	G bulge; other site
701521001024	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
701521001025	tetramer (dimer of dimers) interface [polypeptide binding]; other site
701521001026	active site
701521001027	dimer interface [polypeptide binding]; other site
701521001028	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
701521001029	Coenzyme A binding pocket [chemical binding]; other site
701521001030	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
701521001031	trimer interface [polypeptide binding]; other site
701521001032	active site
701521001033	DNA repair protein RadA; Provisional; Region: PRK11823
701521001034	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
701521001035	Walker A motif/ATP binding site; other site
701521001036	ATP binding site [chemical binding]; other site
701521001037	Walker B motif; other site
701521001038	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
701521001039	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
701521001040	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
701521001041	putative active site [active]
701521001042	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
701521001043	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
701521001044	active site
701521001045	HIGH motif; other site
701521001046	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
701521001047	active site
701521001048	KMSKS motif; other site
701521001049	Short repeat of unknown function (DUF308); Region: DUF308; cl15828
701521001050	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
701521001051	metal binding site 2 [ion binding]; metal-binding site
701521001052	putative DNA binding helix; other site
701521001053	metal binding site 1 [ion binding]; metal-binding site
701521001054	dimer interface [polypeptide binding]; other site
701521001055	structural Zn2+ binding site [ion binding]; other site
701521001056	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
701521001057	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
701521001058	putative substrate translocation pore; other site
701521001059	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
701521001060	Tropomyosin like; Region: Tropomyosin_1; pfam12718
701521001061	H+ Antiporter protein; Region: 2A0121; TIGR00900
701521001062	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
701521001063	putative substrate translocation pore; other site
701521001064	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
701521001065	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
701521001066	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
701521001067	Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561
701521001068	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
701521001069	active site
701521001070	motif I; other site
701521001071	motif II; other site
701521001072	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
701521001073	NrdI Flavodoxin like; Region: Flavodoxin_NdrI; cl17293
701521001074	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
701521001075	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
701521001076	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
701521001077	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
701521001078	Domain of unknown function DUF21; Region: DUF21; pfam01595
701521001079	FOG: CBS domain [General function prediction only]; Region: COG0517
701521001080	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
701521001081	Transporter associated domain; Region: CorC_HlyC; smart01091
701521001082	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
701521001083	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
701521001084	active site
701521001085	catalytic tetrad [active]
701521001086	methyl viologen resistance protein SmvA; Provisional; Region: PRK14995
701521001087	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
701521001088	putative substrate translocation pore; other site
701521001089	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
701521001090	Predicted transcriptional regulators [Transcription]; Region: COG1695
701521001091	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
701521001092	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
701521001093	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
701521001094	substrate binding pocket [chemical binding]; other site
701521001095	membrane-bound complex binding site; other site
701521001096	hinge residues; other site
701521001097	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
701521001098	dimer interface [polypeptide binding]; other site
701521001099	conserved gate region; other site
701521001100	putative PBP binding loops; other site
701521001101	ABC-ATPase subunit interface; other site
701521001102	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
701521001103	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
701521001104	Walker A/P-loop; other site
701521001105	ATP binding site [chemical binding]; other site
701521001106	Q-loop/lid; other site
701521001107	ABC transporter signature motif; other site
701521001108	Walker B; other site
701521001109	D-loop; other site
701521001110	H-loop/switch region; other site
701521001111	EamA-like transporter family; Region: EamA; pfam00892
701521001112	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
701521001113	EamA-like transporter family; Region: EamA; pfam00892
701521001114	SnoaL-like domain; Region: SnoaL_4; pfam13577
701521001115	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
701521001116	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
701521001117	Ca binding site [ion binding]; other site
701521001118	active site
701521001119	catalytic site [active]
701521001120	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
701521001121	active site
701521001122	catalytic residues [active]
701521001123	biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244
701521001124	NADH(P)-binding; Region: NAD_binding_10; pfam13460
701521001125	NAD binding site [chemical binding]; other site
701521001126	substrate binding site [chemical binding]; other site
701521001127	putative active site [active]
701521001128	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
701521001129	dimer interface [polypeptide binding]; other site
701521001130	substrate binding site [chemical binding]; other site
701521001131	ATP binding site [chemical binding]; other site
701521001132	Predicted transcriptional regulators [Transcription]; Region: COG1695
701521001133	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
701521001134	Predicted membrane protein [Function unknown]; Region: COG4709
701521001135	hypothetical protein; Provisional; Region: PRK00967
701521001136	Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754
701521001137	Nitroreductase-like family 4.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140
701521001138	dimer interface [polypeptide binding]; other site
701521001139	FMN binding site [chemical binding]; other site
701521001140	DNA polymerase IV; Reviewed; Region: PRK03103
701521001141	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
701521001142	active site
701521001143	DNA binding site [nucleotide binding]
701521001144	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
701521001145	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
701521001146	PGAP1-like protein; Region: PGAP1; pfam07819
701521001147	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
701521001148	substrate binding site [chemical binding]; other site
701521001149	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
701521001150	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
701521001151	Walker A/P-loop; other site
701521001152	ATP binding site [chemical binding]; other site
701521001153	Q-loop/lid; other site
701521001154	ABC transporter signature motif; other site
701521001155	Walker B; other site
701521001156	D-loop; other site
701521001157	H-loop/switch region; other site
701521001158	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
701521001159	Putative exporter of polyketide antibiotics [Cell envelope biogenesis, outer membrane]; Region: TnrB3; COG3559
701521001160	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
701521001161	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
701521001162	Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087
701521001163	active site
701521001164	putative catalytic site [active]
701521001165	DNA binding site [nucleotide binding]
701521001166	putative phosphate binding site [ion binding]; other site
701521001167	metal binding site A [ion binding]; metal-binding site
701521001168	AP binding site [nucleotide binding]; other site
701521001169	metal binding site B [ion binding]; metal-binding site
701521001170	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
701521001171	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
701521001172	nucleotide binding pocket [chemical binding]; other site
701521001173	K-X-D-G motif; other site
701521001174	catalytic site [active]
701521001175	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
701521001176	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
701521001177	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
701521001178	Dimer interface [polypeptide binding]; other site
701521001179	BRCT sequence motif; other site
701521001180	Predicted membrane protein [Function unknown]; Region: COG2246
701521001181	GtrA-like protein; Region: GtrA; pfam04138
701521001182	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
701521001183	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
701521001184	Ligand binding site; other site
701521001185	Putative Catalytic site; other site
701521001186	DXD motif; other site
701521001187	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
701521001188	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
701521001189	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
701521001190	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
701521001191	Walker A/P-loop; other site
701521001192	ATP binding site [chemical binding]; other site
701521001193	Q-loop/lid; other site
701521001194	ABC transporter signature motif; other site
701521001195	Walker B; other site
701521001196	D-loop; other site
701521001197	H-loop/switch region; other site
701521001198	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
701521001199	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
701521001200	active site
701521001201	phosphorylation site [posttranslational modification]
701521001202	intermolecular recognition site; other site
701521001203	dimerization interface [polypeptide binding]; other site
701521001204	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
701521001205	DNA binding site [nucleotide binding]
701521001206	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
701521001207	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
701521001208	dimer interface [polypeptide binding]; other site
701521001209	phosphorylation site [posttranslational modification]
701521001210	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
701521001211	ATP binding site [chemical binding]; other site
701521001212	Mg2+ binding site [ion binding]; other site
701521001213	G-X-G motif; other site
701521001214	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
701521001215	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
701521001216	active site
701521001217	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
701521001218	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
701521001219	Ligand binding site; other site
701521001220	Putative Catalytic site; other site
701521001221	DXD motif; other site
701521001222	conserved hypothetical integral membrane protein; Region: TIGR03766
701521001223	Ion channel; Region: Ion_trans_2; pfam07885
701521001224	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
701521001225	active site
701521001226	homotetramer interface [polypeptide binding]; other site
701521001227	homodimer interface [polypeptide binding]; other site
701521001228	Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590
701521001229	Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662
701521001230	active site
701521001231	Zn binding site [ion binding]; other site
701521001232	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
701521001233	Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693
701521001234	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
701521001235	RNA/DNA hybrid binding site [nucleotide binding]; other site
701521001236	active site
701521001237	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
701521001238	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
701521001239	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4918
701521001240	H+ Antiporter protein; Region: 2A0121; TIGR00900
701521001241	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
701521001242	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
701521001243	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
701521001244	active site
701521001245	metal binding site [ion binding]; metal-binding site
701521001246	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
701521001247	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
701521001248	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
701521001249	putative catalytic cysteine [active]
701521001250	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
701521001251	putative active site [active]
701521001252	metal binding site [ion binding]; metal-binding site
701521001253	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
701521001254	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
701521001255	active site
701521001256	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
701521001257	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
701521001258	active site
701521001259	trimer interface [polypeptide binding]; other site
701521001260	allosteric site; other site
701521001261	active site lid [active]
701521001262	hexamer (dimer of trimers) interface [polypeptide binding]; other site
701521001263	LytTr DNA-binding domain; Region: LytTR; smart00850
701521001264	Predicted membrane protein [Function unknown]; Region: COG4758
701521001265	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130
701521001266	Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922
701521001267	L-aspartate oxidase; Provisional; Region: PRK08401
701521001268	Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213
701521001269	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
701521001270	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
701521001271	active site
701521001272	P-loop; other site
701521001273	phosphorylation site [posttranslational modification]
701521001274	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
701521001275	active site
701521001276	P-loop; other site
701521001277	Transcriptional antiterminator [Transcription]; Region: BglG; COG3711
701521001278	PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568
701521001279	active site
701521001280	P-loop; other site
701521001281	phosphorylation site [posttranslational modification]
701521001282	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163
701521001283	active site
701521001284	phosphorylation site [posttranslational modification]
701521001285	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
701521001286	active site
701521001287	phosphorylation site [posttranslational modification]
701521001288	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
701521001289	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
701521001290	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
701521001291	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
701521001292	propionate/acetate kinase; Provisional; Region: PRK12379
701521001293	phosphotransacetylase; Reviewed; Region: eutD; PRK09653
701521001294	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
701521001295	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
701521001296	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
701521001297	active site
701521001298	HIGH motif; other site
701521001299	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
701521001300	KMSKS motif; other site
701521001301	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
701521001302	tRNA binding surface [nucleotide binding]; other site
701521001303	anticodon binding site; other site
701521001304	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
701521001305	active site
701521001306	metal binding site [ion binding]; metal-binding site
701521001307	dimerization interface [polypeptide binding]; other site
701521001308	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
701521001309	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
701521001310	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
701521001311	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
701521001312	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
701521001313	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
701521001314	DNA binding residues [nucleotide binding]
701521001315	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
701521001316	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
701521001317	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
701521001318	putative homodimer interface [polypeptide binding]; other site
701521001319	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
701521001320	heterodimer interface [polypeptide binding]; other site
701521001321	homodimer interface [polypeptide binding]; other site
701521001322	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
701521001323	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
701521001324	23S rRNA interface [nucleotide binding]; other site
701521001325	L7/L12 interface [polypeptide binding]; other site
701521001326	putative thiostrepton binding site; other site
701521001327	L25 interface [polypeptide binding]; other site
701521001328	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
701521001329	mRNA/rRNA interface [nucleotide binding]; other site
701521001330	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
701521001331	23S rRNA interface [nucleotide binding]; other site
701521001332	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
701521001333	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
701521001334	core dimer interface [polypeptide binding]; other site
701521001335	peripheral dimer interface [polypeptide binding]; other site
701521001336	L10 interface [polypeptide binding]; other site
701521001337	L11 interface [polypeptide binding]; other site
701521001338	putative EF-Tu interaction site [polypeptide binding]; other site
701521001339	putative EF-G interaction site [polypeptide binding]; other site
701521001340	Low-density lipoprotein-receptor YWTD domain; Region: LY; smart00135
701521001341	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
701521001342	active site
701521001343	dimer interface [polypeptide binding]; other site
701521001344	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
701521001345	active site
701521001346	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
701521001347	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
701521001348	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
701521001349	dihydroorotase; Validated; Region: pyrC; PRK09357
701521001350	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
701521001351	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
701521001352	active site
701521001353	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
701521001354	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
701521001355	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
701521001356	catalytic site [active]
701521001357	subunit interface [polypeptide binding]; other site
701521001358	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
701521001359	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
701521001360	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
701521001361	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
701521001362	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
701521001363	ATP-grasp domain; Region: ATP-grasp_4; cl17255
701521001364	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
701521001365	IMP binding site; other site
701521001366	dimer interface [polypeptide binding]; other site
701521001367	interdomain contacts; other site
701521001368	partial ornithine binding site; other site
701521001369	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
701521001370	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
701521001371	heterodimer interface [polypeptide binding]; other site
701521001372	active site
701521001373	FMN binding site [chemical binding]; other site
701521001374	homodimer interface [polypeptide binding]; other site
701521001375	substrate binding site [chemical binding]; other site
701521001376	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
701521001377	Predicted integral membrane protein [Function unknown]; Region: COG0392
701521001378	Uncharacterized conserved protein [Function unknown]; Region: COG2898
701521001379	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
701521001380	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
701521001381	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
701521001382	putative substrate translocation pore; other site
701521001383	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
701521001384	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
701521001385	ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966
701521001386	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
701521001387	dimer interface [polypeptide binding]; other site
701521001388	putative radical transfer pathway; other site
701521001389	diiron center [ion binding]; other site
701521001390	tyrosyl radical; other site
701521001391	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306
701521001392	Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343
701521001393	Class I ribonucleotide reductase; Region: RNR_I; cd01679
701521001394	active site
701521001395	dimer interface [polypeptide binding]; other site
701521001396	catalytic residues [active]
701521001397	effector binding site; other site
701521001398	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
701521001399	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
701521001400	catalytic residues [active]
701521001401	Helix-turn-helix domain; Region: HTH_28; pfam13518
701521001402	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
701521001403	Helix-turn-helix domain; Region: HTH_28; pfam13518
701521001404	Integrase core domain; Region: rve; pfam00665
701521001405	Integrase core domain; Region: rve_2; pfam13333
701521001406	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
701521001407	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
701521001408	S-adenosylmethionine binding site [chemical binding]; other site
701521001409	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
701521001410	nucleoside/Zn binding site; other site
701521001411	dimer interface [polypeptide binding]; other site
701521001412	catalytic motif [active]
701521001413	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
701521001414	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
701521001415	Walker A motif; other site
701521001416	ATP binding site [chemical binding]; other site
701521001417	Walker B motif; other site
701521001418	arginine finger; other site
701521001419	hypothetical protein; Validated; Region: PRK00153
701521001420	recombination protein RecR; Reviewed; Region: recR; PRK00076
701521001421	RecR protein; Region: RecR; pfam02132
701521001422	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
701521001423	putative active site [active]
701521001424	putative metal-binding site [ion binding]; other site
701521001425	tetramer interface [polypeptide binding]; other site
701521001426	thymidylate kinase; Validated; Region: tmk; PRK00698
701521001427	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
701521001428	TMP-binding site; other site
701521001429	ATP-binding site [chemical binding]; other site
701521001430	Protein of unknown function (DUF970); Region: DUF970; pfam06153
701521001431	DNA polymerase III subunit delta'; Validated; Region: PRK08058
701521001432	DNA polymerase III subunit delta'; Validated; Region: PRK08485
701521001433	Protein of unknown function (DUF972); Region: DUF972; pfam06156
701521001434	Predicted methyltransferases [General function prediction only]; Region: COG0313
701521001435	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
701521001436	putative SAM binding site [chemical binding]; other site
701521001437	putative homodimer interface [polypeptide binding]; other site
701521001438	Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643
701521001439	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
701521001440	active site
701521001441	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
701521001442	active site 2 [active]
701521001443	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
701521001444	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
701521001445	NAD binding site [chemical binding]; other site
701521001446	homodimer interface [polypeptide binding]; other site
701521001447	active site
701521001448	substrate binding site [chemical binding]; other site
701521001449	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
701521001450	Glycoprotease family; Region: Peptidase_M22; pfam00814
701521001451	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
701521001452	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
701521001453	Coenzyme A binding pocket [chemical binding]; other site
701521001454	UGMP family protein; Validated; Region: PRK09604
701521001455	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
701521001456	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
701521001457	Beta-lactamase; Region: Beta-lactamase; pfam00144
701521001458	CAAX protease self-immunity; Region: Abi; pfam02517
701521001459	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
701521001460	oligomerisation interface [polypeptide binding]; other site
701521001461	mobile loop; other site
701521001462	roof hairpin; other site
701521001463	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
701521001464	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
701521001465	ring oligomerisation interface [polypeptide binding]; other site
701521001466	ATP/Mg binding site [chemical binding]; other site
701521001467	stacking interactions; other site
701521001468	hinge regions; other site
701521001469	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
701521001470	K+ potassium transporter; Region: K_trans; cl15781
701521001471	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
701521001472	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
701521001473	Mg++ binding site [ion binding]; other site
701521001474	putative catalytic motif [active]
701521001475	substrate binding site [chemical binding]; other site
701521001476	Uncharacterized conserved protein [Function unknown]; Region: COG1739
701521001477	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
701521001478	Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098
701521001479	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
701521001480	ATP binding site [chemical binding]; other site
701521001481	putative Mg++ binding site [ion binding]; other site
701521001482	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
701521001483	nucleotide binding region [chemical binding]; other site
701521001484	ATP-binding site [chemical binding]; other site
701521001485	comF family protein; Region: comF; TIGR00201
701521001486	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
701521001487	active site
701521001488	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
701521001489	30S subunit binding site; other site
701521001490	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12906
701521001491	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
701521001492	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
701521001493	nucleotide binding region [chemical binding]; other site
701521001494	ATP-binding site [chemical binding]; other site
701521001495	peptide chain release factor 2; Provisional; Region: PRK05589
701521001496	This domain is found in peptide chain release factors; Region: PCRF; smart00937
701521001497	RF-1 domain; Region: RF-1; pfam00472
701521001498	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
701521001499	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
701521001500	active site
701521001501	phosphorylation site [posttranslational modification]
701521001502	intermolecular recognition site; other site
701521001503	dimerization interface [polypeptide binding]; other site
701521001504	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
701521001505	DNA binding site [nucleotide binding]
701521001506	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
701521001507	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
701521001508	dimer interface [polypeptide binding]; other site
701521001509	phosphorylation site [posttranslational modification]
701521001510	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
701521001511	ATP binding site [chemical binding]; other site
701521001512	Mg2+ binding site [ion binding]; other site
701521001513	G-X-G motif; other site
701521001514	PBP superfamily domain; Region: PBP_like_2; cl17296
701521001515	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
701521001516	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
701521001517	dimer interface [polypeptide binding]; other site
701521001518	conserved gate region; other site
701521001519	putative PBP binding loops; other site
701521001520	ABC-ATPase subunit interface; other site
701521001521	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
701521001522	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
701521001523	dimer interface [polypeptide binding]; other site
701521001524	conserved gate region; other site
701521001525	putative PBP binding loops; other site
701521001526	ABC-ATPase subunit interface; other site
701521001527	phosphate transporter ATP-binding protein; Provisional; Region: PRK14237
701521001528	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
701521001529	Walker A/P-loop; other site
701521001530	ATP binding site [chemical binding]; other site
701521001531	Q-loop/lid; other site
701521001532	ABC transporter signature motif; other site
701521001533	Walker B; other site
701521001534	D-loop; other site
701521001535	H-loop/switch region; other site
701521001536	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
701521001537	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
701521001538	Walker A/P-loop; other site
701521001539	ATP binding site [chemical binding]; other site
701521001540	Q-loop/lid; other site
701521001541	ABC transporter signature motif; other site
701521001542	Walker B; other site
701521001543	D-loop; other site
701521001544	H-loop/switch region; other site
701521001545	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
701521001546	PhoU domain; Region: PhoU; pfam01895
701521001547	PhoU domain; Region: PhoU; pfam01895
701521001548	PspC domain; Region: PspC; pfam04024
701521001549	HPr kinase/phosphorylase; Provisional; Region: PRK05428
701521001550	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
701521001551	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
701521001552	Hpr binding site; other site
701521001553	active site
701521001554	homohexamer subunit interaction site [polypeptide binding]; other site
701521001555	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
701521001556	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
701521001557	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
701521001558	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
701521001559	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
701521001560	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
701521001561	active site
701521001562	tetramer interface; other site
701521001563	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
701521001564	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
701521001565	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
701521001566	amino acid transporter; Region: 2A0306; TIGR00909
701521001567	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
701521001568	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
701521001569	active site
701521001570	substrate binding site [chemical binding]; other site
701521001571	metal binding site [ion binding]; metal-binding site
701521001572	excinuclease ABC subunit B; Provisional; Region: PRK05298
701521001573	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
701521001574	ATP binding site [chemical binding]; other site
701521001575	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
701521001576	nucleotide binding region [chemical binding]; other site
701521001577	ATP-binding site [chemical binding]; other site
701521001578	Ultra-violet resistance protein B; Region: UvrB; pfam12344
701521001579	UvrB/uvrC motif; Region: UVR; pfam02151
701521001580	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
701521001581	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
701521001582	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
701521001583	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
701521001584	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
701521001585	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
701521001586	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
701521001587	phosphate binding site [ion binding]; other site
701521001588	putative substrate binding pocket [chemical binding]; other site
701521001589	dimer interface [polypeptide binding]; other site
701521001590	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
701521001591	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
701521001592	Clp protease; Region: CLP_protease; pfam00574
701521001593	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
701521001594	oligomer interface [polypeptide binding]; other site
701521001595	active site residues [active]
701521001596	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
701521001597	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
701521001598	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
701521001599	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
701521001600	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
701521001601	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
701521001602	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
701521001603	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
701521001604	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
701521001605	Phosphoglycerate kinase; Region: PGK; pfam00162
701521001606	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
701521001607	substrate binding site [chemical binding]; other site
701521001608	hinge regions; other site
701521001609	ADP binding site [chemical binding]; other site
701521001610	catalytic site [active]
701521001611	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
701521001612	triosephosphate isomerase; Provisional; Region: PRK14567
701521001613	substrate binding site [chemical binding]; other site
701521001614	dimer interface [polypeptide binding]; other site
701521001615	catalytic triad [active]
701521001616	enolase; Provisional; Region: eno; PRK00077
701521001617	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
701521001618	dimer interface [polypeptide binding]; other site
701521001619	metal binding site [ion binding]; metal-binding site
701521001620	substrate binding pocket [chemical binding]; other site
701521001621	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
701521001622	ribonuclease R; Region: RNase_R; TIGR02063
701521001623	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
701521001624	RNB domain; Region: RNB; pfam00773
701521001625	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
701521001626	RNA binding site [nucleotide binding]; other site
701521001627	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
701521001628	SmpB-tmRNA interface; other site
701521001629	GntP family permease; Region: GntP_permease; pfam02447
701521001630	fructuronate transporter; Provisional; Region: PRK10034; cl15264
701521001631	gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314
701521001632	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
701521001633	N- and C-terminal domain interface [polypeptide binding]; other site
701521001634	active site
701521001635	catalytic site [active]
701521001636	metal binding site [ion binding]; metal-binding site
701521001637	carbohydrate binding site [chemical binding]; other site
701521001638	ATP binding site [chemical binding]; other site
701521001639	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
701521001640	Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023
701521001641	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
701521001642	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
701521001643	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
701521001644	putative active site [active]
701521001645	Amino acid permease; Region: AA_permease_2; pfam13520
701521001646	Histone acetyltransferase HPA2 and related acetyltransferases [Transcription / General function prediction only]; Region: WecD; COG0454
701521001647	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
701521001648	Coenzyme A binding pocket [chemical binding]; other site
701521001649	Tubby C 2; Region: Tub_2; cl02043
701521001650	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
701521001651	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
701521001652	active site
701521001653	motif I; other site
701521001654	motif II; other site
701521001655	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
701521001656	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
701521001657	ligand binding site [chemical binding]; other site
701521001658	active site
701521001659	UGI interface [polypeptide binding]; other site
701521001660	catalytic site [active]
701521001661	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
701521001662	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
701521001663	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
701521001664	Coenzyme A binding pocket [chemical binding]; other site
701521001665	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
701521001666	active site
701521001667	catalytic site [active]
701521001668	substrate binding site [chemical binding]; other site
701521001669	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
701521001670	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
701521001671	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
701521001672	FAD binding domain; Region: FAD_binding_4; pfam01565
701521001673	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
701521001674	Uncharacterized conserved protein [Function unknown]; Region: COG1624
701521001675	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
701521001676	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4856
701521001677	YbbR-like protein; Region: YbbR; pfam07949
701521001678	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
701521001679	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
701521001680	active site
701521001681	substrate binding site [chemical binding]; other site
701521001682	metal binding site [ion binding]; metal-binding site
701521001683	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
701521001684	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
701521001685	glutaminase active site [active]
701521001686	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
701521001687	dimer interface [polypeptide binding]; other site
701521001688	active site
701521001689	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
701521001690	dimer interface [polypeptide binding]; other site
701521001691	active site
701521001692	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
701521001693	dimerization interface [polypeptide binding]; other site
701521001694	putative DNA binding site [nucleotide binding]; other site
701521001695	putative Zn2+ binding site [ion binding]; other site
701521001696	myosin-cross-reactive antigen; Provisional; Region: PRK13977
701521001697	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
701521001698	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
701521001699	putative active site [active]
701521001700	putative metal binding site [ion binding]; other site
701521001701	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
701521001702	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
701521001703	metal binding site [ion binding]; metal-binding site
701521001704	active site
701521001705	I-site; other site
701521001706	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
701521001707	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
701521001708	glycerate dehydrogenase; Provisional; Region: PRK06487
701521001709	NAD binding site [chemical binding]; other site
701521001710	LicD family; Region: LicD; cl01378
701521001711	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
701521001712	phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189
701521001713	Int/Topo IB signature motif; other site
701521001714	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
701521001715	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
701521001716	non-specific DNA binding site [nucleotide binding]; other site
701521001717	salt bridge; other site
701521001718	sequence-specific DNA binding site [nucleotide binding]; other site
701521001719	Helix-turn-helix domain; Region: HTH_17; cl17695
701521001720	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
701521001721	polymerase nucleotide-binding site; other site
701521001722	DNA-binding residues [nucleotide binding]; DNA binding site
701521001723	nucleotide binding site [chemical binding]; other site
701521001724	primase nucleotide-binding site [nucleotide binding]; other site
701521001725	Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942
701521001726	D5 N terminal like; Region: D5_N; cl07360
701521001727	phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613
701521001728	phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637
701521001729	Phage head-tail joining protein; Region: Phage_H_T_join; cl11461
701521001730	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
701521001731	active site
701521001732	Phage terminase, small subunit; Region: Terminase_4; pfam05119
701521001733	Phage Terminase; Region: Terminase_1; pfam03354
701521001734	Phage portal protein; Region: Phage_portal; pfam04860
701521001735	Phage-related protein [Function unknown]; Region: COG4695; cl01923
701521001736	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
701521001737	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
701521001738	Phage capsid family; Region: Phage_capsid; pfam05065
701521001739	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
701521001740	oligomerization interface [polypeptide binding]; other site
701521001741	conserved hypothetical integral membrane protein; Region: TIGR03766
701521001742	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
701521001743	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
701521001744	UbiA prenyltransferase family; Region: UbiA; pfam01040
701521001745	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
701521001746	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
701521001747	dimer interface [polypeptide binding]; other site
701521001748	active site
701521001749	metal binding site [ion binding]; metal-binding site
701521001750	putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247
701521001751	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
701521001752	Walker A/P-loop; other site
701521001753	ATP binding site [chemical binding]; other site
701521001754	Q-loop/lid; other site
701521001755	ABC transporter signature motif; other site
701521001756	Walker B; other site
701521001757	D-loop; other site
701521001758	H-loop/switch region; other site
701521001759	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
701521001760	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
701521001761	Transglycosylase-like domain; Region: Transglycosylas; pfam06737
701521001762	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
701521001763	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
701521001764	active site
701521001765	phosphorylation site [posttranslational modification]
701521001766	intermolecular recognition site; other site
701521001767	dimerization interface [polypeptide binding]; other site
701521001768	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
701521001769	DNA binding site [nucleotide binding]
701521001770	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
701521001771	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
701521001772	dimerization interface [polypeptide binding]; other site
701521001773	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
701521001774	dimer interface [polypeptide binding]; other site
701521001775	phosphorylation site [posttranslational modification]
701521001776	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
701521001777	ATP binding site [chemical binding]; other site
701521001778	Mg2+ binding site [ion binding]; other site
701521001779	G-X-G motif; other site
701521001780	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
701521001781	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
701521001782	dimer interface [polypeptide binding]; other site
701521001783	active site
701521001784	metal binding site [ion binding]; metal-binding site
701521001785	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
701521001786	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
701521001787	intersubunit interface [polypeptide binding]; other site
701521001788	active site
701521001789	zinc binding site [ion binding]; other site
701521001790	Na+ binding site [ion binding]; other site
701521001791	Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975
701521001792	preprotein translocase subunit SecA; Reviewed; Region: PRK09200
701521001793	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
701521001794	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417
701521001795	SecY translocase; Region: SecY; pfam00344
701521001796	accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713
701521001797	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
701521001798	accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712
701521001799	accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711
701521001800	accessory Sec system glycosylation protein GtfA; Region: TIGR02918
701521001801	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
701521001802	accessory Sec system glycosyltransferase GtfB; Region: TIGR02919
701521001803	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
701521001804	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
701521001805	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
701521001806	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
701521001807	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
701521001808	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
701521001809	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
701521001810	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
701521001811	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
701521001812	MucBP domain; Region: MucBP; pfam06458
701521001813	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
701521001814	glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097
701521001815	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
701521001816	active site
701521001817	dimer interface [polypeptide binding]; other site
701521001818	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
701521001819	dimer interface [polypeptide binding]; other site
701521001820	active site
701521001821	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
701521001822	Class III ribonucleotide reductase; Region: RNR_III; cd01675
701521001823	effector binding site; other site
701521001824	active site
701521001825	Zn binding site [ion binding]; other site
701521001826	glycine loop; other site
701521001827	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
701521001828	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
701521001829	heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512
701521001830	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
701521001831	Soluble P-type ATPase [General function prediction only]; Region: COG4087
701521001832	large tegument protein UL36; Provisional; Region: PHA03247
701521001833	beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814
701521001834	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
701521001835	glycosyltransferase, SP_1767 family; Region: glyco_access_1; TIGR03728
701521001836	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
701521001837	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
701521001838	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
701521001839	NAD(P) binding site [chemical binding]; other site
701521001840	catalytic residues [active]
701521001841	manganese transport protein MntH; Reviewed; Region: PRK00701
701521001842	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
701521001843	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
701521001844	Ligand Binding Site [chemical binding]; other site
701521001845	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
701521001846	Integrase core domain; Region: rve; pfam00665
701521001847	Uncharacterized conserved protein [Function unknown]; Region: COG1434
701521001848	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
701521001849	putative active site [active]
701521001850	Protein of unknown function (DUF1093); Region: DUF1093; cl02185
701521001851	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
701521001852	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
701521001853	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
701521001854	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
701521001855	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
701521001856	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
701521001857	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
701521001858	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
701521001859	Walker A/P-loop; other site
701521001860	ATP binding site [chemical binding]; other site
701521001861	Q-loop/lid; other site
701521001862	ABC transporter signature motif; other site
701521001863	Walker B; other site
701521001864	D-loop; other site
701521001865	H-loop/switch region; other site
701521001866	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
701521001867	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
701521001868	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
701521001869	Walker A/P-loop; other site
701521001870	ATP binding site [chemical binding]; other site
701521001871	Q-loop/lid; other site
701521001872	ABC transporter signature motif; other site
701521001873	Walker B; other site
701521001874	D-loop; other site
701521001875	H-loop/switch region; other site
701521001876	Beta-lactamase; Region: Beta-lactamase; pfam00144
701521001877	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
701521001878	Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482
701521001879	mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218
701521001880	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
701521001881	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
701521001882	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
701521001883	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
701521001884	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
701521001885	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
701521001886	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
701521001887	catalytic triad [active]
701521001888	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
701521001889	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
701521001890	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
701521001891	thymidine kinase; Provisional; Region: PRK04296
701521001892	peptide chain release factor 1; Validated; Region: prfA; PRK00591
701521001893	This domain is found in peptide chain release factors; Region: PCRF; smart00937
701521001894	RF-1 domain; Region: RF-1; pfam00472
701521001895	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
701521001896	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
701521001897	S-adenosylmethionine binding site [chemical binding]; other site
701521001898	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
701521001899	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
701521001900	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
701521001901	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
701521001902	dimer interface [polypeptide binding]; other site
701521001903	active site
701521001904	glycine-pyridoxal phosphate binding site [chemical binding]; other site
701521001905	folate binding site [chemical binding]; other site
701521001906	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
701521001907	active site
701521001908	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
701521001909	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
701521001910	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
701521001911	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
701521001912	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
701521001913	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
701521001914	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
701521001915	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
701521001916	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
701521001917	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
701521001918	beta subunit interaction interface [polypeptide binding]; other site
701521001919	Walker A motif; other site
701521001920	ATP binding site [chemical binding]; other site
701521001921	Walker B motif; other site
701521001922	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
701521001923	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
701521001924	core domain interface [polypeptide binding]; other site
701521001925	delta subunit interface [polypeptide binding]; other site
701521001926	epsilon subunit interface [polypeptide binding]; other site
701521001927	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
701521001928	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
701521001929	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
701521001930	alpha subunit interaction interface [polypeptide binding]; other site
701521001931	Walker A motif; other site
701521001932	ATP binding site [chemical binding]; other site
701521001933	Walker B motif; other site
701521001934	inhibitor binding site; inhibition site
701521001935	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
701521001936	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
701521001937	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
701521001938	gamma subunit interface [polypeptide binding]; other site
701521001939	epsilon subunit interface [polypeptide binding]; other site
701521001940	LBP interface [polypeptide binding]; other site
701521001941	Protein of unknown function (DUF1146); Region: DUF1146; pfam06612
701521001942	Haemolytic domain; Region: Haemolytic; pfam01809
701521001943	Protein of unknown function (DUF2969); Region: DUF2969; pfam11184
701521001944	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
701521001945	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
701521001946	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
701521001947	Walker A/P-loop; other site
701521001948	ATP binding site [chemical binding]; other site
701521001949	Q-loop/lid; other site
701521001950	ABC transporter signature motif; other site
701521001951	Walker B; other site
701521001952	D-loop; other site
701521001953	H-loop/switch region; other site
701521001954	NIL domain; Region: NIL; pfam09383
701521001955	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
701521001956	dimer interface [polypeptide binding]; other site
701521001957	conserved gate region; other site
701521001958	putative PBP binding loops; other site
701521001959	ABC-ATPase subunit interface; other site
701521001960	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
701521001961	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
701521001962	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
701521001963	putative catalytic site [active]
701521001964	putative phosphate binding site [ion binding]; other site
701521001965	putative phosphate binding site [ion binding]; other site
701521001966	putative metal binding site [ion binding]; other site
701521001967	Predicted transcriptional regulators [Transcription]; Region: COG1725
701521001968	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
701521001969	DNA-binding site [nucleotide binding]; DNA binding site
701521001970	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
701521001971	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
701521001972	Walker A/P-loop; other site
701521001973	ATP binding site [chemical binding]; other site
701521001974	Q-loop/lid; other site
701521001975	ABC transporter signature motif; other site
701521001976	Walker B; other site
701521001977	D-loop; other site
701521001978	H-loop/switch region; other site
701521001979	Protein of unknown function (DUF975); Region: DUF975; cl10504
701521001980	amino acid transporter; Region: 2A0306; TIGR00909
701521001981	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
701521001982	Protein of unknown function (DUF2785); Region: DUF2785; pfam10978
701521001983	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
701521001984	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
701521001985	putative NAD(P) binding site [chemical binding]; other site
701521001986	dimer interface [polypeptide binding]; other site
701521001987	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
701521001988	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
701521001989	ATP-grasp domain; Region: ATP-grasp_4; cl17255
701521001990	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
701521001991	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
701521001992	Ligand Binding Site [chemical binding]; other site
701521001993	recombination factor protein RarA; Reviewed; Region: PRK13342
701521001994	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
701521001995	Walker A motif; other site
701521001996	ATP binding site [chemical binding]; other site
701521001997	Walker B motif; other site
701521001998	arginine finger; other site
701521001999	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
701521002000	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
701521002001	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
701521002002	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
701521002003	RNA binding surface [nucleotide binding]; other site
701521002004	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
701521002005	Septation ring formation regulator, EzrA; Region: EzrA; pfam06160
701521002006	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
701521002007	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
701521002008	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
701521002009	catalytic residue [active]
701521002010	thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565
701521002011	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
701521002012	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
701521002013	Ligand Binding Site [chemical binding]; other site
701521002014	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
701521002015	dimer interface [polypeptide binding]; other site
701521002016	catalytic triad [active]
701521002017	peroxidatic and resolving cysteines [active]
701521002018	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
701521002019	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
701521002020	active site
701521002021	HIGH motif; other site
701521002022	nucleotide binding site [chemical binding]; other site
701521002023	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
701521002024	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
701521002025	active site
701521002026	KMSKS motif; other site
701521002027	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
701521002028	tRNA binding surface [nucleotide binding]; other site
701521002029	anticodon binding site; other site
701521002030	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
701521002031	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
701521002032	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
701521002033	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
701521002034	DNA repair protein radc; Region: radc; TIGR00608
701521002035	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
701521002036	MPN+ (JAMM) motif; other site
701521002037	Zinc-binding site [ion binding]; other site
701521002038	rod shape-determining protein MreC; Provisional; Region: PRK13922
701521002039	rod shape-determining protein MreC; Region: MreC; pfam04085
701521002040	rod shape-determining protein MreD; Region: MreD; cl01087
701521002041	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
701521002042	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
701521002043	dimer interface [polypeptide binding]; other site
701521002044	conserved gate region; other site
701521002045	putative PBP binding loops; other site
701521002046	ABC-ATPase subunit interface; other site
701521002047	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
701521002048	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
701521002049	Walker A/P-loop; other site
701521002050	ATP binding site [chemical binding]; other site
701521002051	Q-loop/lid; other site
701521002052	ABC transporter signature motif; other site
701521002053	Walker B; other site
701521002054	D-loop; other site
701521002055	H-loop/switch region; other site
701521002056	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
701521002057	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
701521002058	substrate binding pocket [chemical binding]; other site
701521002059	membrane-bound complex binding site; other site
701521002060	hinge residues; other site
701521002061	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
701521002062	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
701521002063	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
701521002064	putative active site [active]
701521002065	catalytic site [active]
701521002066	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
701521002067	putative active site [active]
701521002068	catalytic site [active]
701521002069	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
701521002070	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
701521002071	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
701521002072	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
701521002073	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
701521002074	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
701521002075	classical (c) SDRs; Region: SDR_c; cd05233
701521002076	NAD(P) binding site [chemical binding]; other site
701521002077	active site
701521002078	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
701521002079	non-specific DNA binding site [nucleotide binding]; other site
701521002080	salt bridge; other site
701521002081	sequence-specific DNA binding site [nucleotide binding]; other site
701521002082	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
701521002083	competence damage-inducible protein A; Provisional; Region: PRK00549
701521002084	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
701521002085	putative MPT binding site; other site
701521002086	Competence-damaged protein; Region: CinA; pfam02464
701521002087	recombinase A; Provisional; Region: recA; PRK09354
701521002088	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
701521002089	hexamer interface [polypeptide binding]; other site
701521002090	Walker A motif; other site
701521002091	ATP binding site [chemical binding]; other site
701521002092	Walker B motif; other site
701521002093	phosphodiesterase; Provisional; Region: PRK12704
701521002094	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
701521002095	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
701521002096	Zn2+ binding site [ion binding]; other site
701521002097	Mg2+ binding site [ion binding]; other site
701521002098	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
701521002099	MutS domain I; Region: MutS_I; pfam01624
701521002100	MutS domain II; Region: MutS_II; pfam05188
701521002101	MutS domain III; Region: MutS_III; pfam05192
701521002102	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
701521002103	Walker A/P-loop; other site
701521002104	ATP binding site [chemical binding]; other site
701521002105	Q-loop/lid; other site
701521002106	ABC transporter signature motif; other site
701521002107	Walker B; other site
701521002108	D-loop; other site
701521002109	H-loop/switch region; other site
701521002110	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
701521002111	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
701521002112	ATP binding site [chemical binding]; other site
701521002113	Mg2+ binding site [ion binding]; other site
701521002114	G-X-G motif; other site
701521002115	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
701521002116	ATP binding site [chemical binding]; other site
701521002117	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
701521002118	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
701521002119	RuvA N terminal domain; Region: RuvA_N; pfam01330
701521002120	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
701521002121	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
701521002122	Walker A motif; other site
701521002123	ATP binding site [chemical binding]; other site
701521002124	Walker B motif; other site
701521002125	arginine finger; other site
701521002126	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
701521002127	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
701521002128	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
701521002129	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
701521002130	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
701521002131	Preprotein translocase subunit; Region: YajC; pfam02699
701521002132	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; cl00583
701521002133	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
701521002134	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
701521002135	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
701521002136	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
701521002137	active site
701521002138	DNA polymerase IV; Validated; Region: PRK02406
701521002139	DNA binding site [nucleotide binding]
701521002140	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
701521002141	DHH family; Region: DHH; pfam01368
701521002142	DHHA1 domain; Region: DHHA1; pfam02272
701521002143	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
701521002144	DEAD-like helicases superfamily; Region: DEXDc; smart00487
701521002145	ATP binding site [chemical binding]; other site
701521002146	Mg++ binding site [ion binding]; other site
701521002147	motif III; other site
701521002148	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
701521002149	nucleotide binding region [chemical binding]; other site
701521002150	ATP-binding site [chemical binding]; other site
701521002151	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
701521002152	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
701521002153	motif 1; other site
701521002154	active site
701521002155	motif 2; other site
701521002156	motif 3; other site
701521002157	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
701521002158	DHHA1 domain; Region: DHHA1; pfam02272
701521002159	hypothetical protein; Provisional; Region: PRK05473
701521002160	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
701521002161	hypothetical protein; Provisional; Region: PRK13678
701521002162	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
701521002163	MutS domain III; Region: MutS_III; pfam05192
701521002164	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
701521002165	Walker A/P-loop; other site
701521002166	ATP binding site [chemical binding]; other site
701521002167	Q-loop/lid; other site
701521002168	ABC transporter signature motif; other site
701521002169	Walker B; other site
701521002170	D-loop; other site
701521002171	H-loop/switch region; other site
701521002172	Smr domain; Region: Smr; pfam01713
701521002173	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
701521002174	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
701521002175	catalytic residues [active]
701521002176	glutamate racemase; Provisional; Region: PRK00865
701521002177	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
701521002178	active site
701521002179	dimerization interface [polypeptide binding]; other site
701521002180	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
701521002181	Mechanosensitive ion channel; Region: MS_channel; pfam00924
701521002182	Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103
701521002183	pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720
701521002184	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
701521002185	PYR/PP interface [polypeptide binding]; other site
701521002186	dimer interface [polypeptide binding]; other site
701521002187	tetramer interface [polypeptide binding]; other site
701521002188	TPP binding site [chemical binding]; other site
701521002189	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
701521002190	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
701521002191	TPP-binding site [chemical binding]; other site
701521002192	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
701521002193	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
701521002194	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
701521002195	active site
701521002196	catabolite control protein A; Region: ccpA; TIGR01481
701521002197	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
701521002198	DNA binding site [nucleotide binding]
701521002199	domain linker motif; other site
701521002200	Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298
701521002201	dimerization interface [polypeptide binding]; other site
701521002202	effector binding site; other site
701521002203	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
701521002204	amphipathic channel; other site
701521002205	Asn-Pro-Ala signature motifs; other site
701521002206	HflC protein; Region: hflC; TIGR01932
701521002207	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
701521002208	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
701521002209	channel protein, hemolysin III family; Region: hlyIII; TIGR01065
701521002210	elongation factor P; Validated; Region: PRK00529
701521002211	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
701521002212	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
701521002213	RNA binding site [nucleotide binding]; other site
701521002214	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
701521002215	RNA binding site [nucleotide binding]; other site
701521002216	VanZ like family; Region: VanZ; pfam04892
701521002217	hypothetical protein; Validated; Region: PRK00110
701521002218	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
701521002219	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
701521002220	substrate binding site [chemical binding]; other site
701521002221	dimer interface [polypeptide binding]; other site
701521002222	ATP binding site [chemical binding]; other site
701521002223	Type II/IV secretion system protein; Region: T2SE; pfam00437
701521002224	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
701521002225	Walker A motif; other site
701521002226	ATP binding site [chemical binding]; other site
701521002227	Walker B motif; other site
701521002228	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
701521002229	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
701521002230	Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537
701521002231	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
701521002232	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
701521002233	hypothetical protein; Provisional; Region: PRK10506
701521002234	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827
701521002235	Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113
701521002236	Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390
701521002237	putative active site [active]
701521002238	putative metal binding site [ion binding]; other site
701521002239	Protein of unknown function (DUF1027); Region: DUF1027; cl09961
701521002240	HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2
701521002241	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
701521002242	active site
701521002243	motif I; other site
701521002244	motif II; other site
701521002245	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
701521002246	Protein of unknown function (DUF1461); Region: DUF1461; pfam07314
701521002247	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
701521002248	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
701521002249	general stress protein 13; Validated; Region: PRK08059
701521002250	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
701521002251	RNA binding site [nucleotide binding]; other site
701521002252	Protein of unknown function (DUF1275); Region: DUF1275; pfam06912
701521002253	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
701521002254	Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032
701521002255	ArsC family; Region: ArsC; pfam03960
701521002256	putative catalytic residues [active]
701521002257	thiol/disulfide switch; other site
701521002258	adaptor protein; Provisional; Region: PRK02315
701521002259	Competence protein CoiA-like family; Region: CoiA; cl11541
701521002260	Thioredoxin; Region: Thioredoxin_5; pfam13743
701521002261	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
701521002262	synthetase active site [active]
701521002263	NTP binding site [chemical binding]; other site
701521002264	metal binding site [ion binding]; metal-binding site
701521002265	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885
701521002266	ATP-NAD kinase; Region: NAD_kinase; pfam01513
701521002267	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
701521002268	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
701521002269	active site
701521002270	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
701521002271	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
701521002272	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
701521002273	Divalent cation transporter; Region: MgtE; pfam01769
701521002274	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
701521002275	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
701521002276	GDP-binding site [chemical binding]; other site
701521002277	ACT binding site; other site
701521002278	IMP binding site; other site
701521002279	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
701521002280	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
701521002281	tetramer interface [polypeptide binding]; other site
701521002282	active site
701521002283	Adenylosuccinate lyase C-terminus; Region: ADSL_C; pfam10397
701521002284	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
701521002285	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
701521002286	PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516
701521002287	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
701521002288	Domain of unknown function DUF20; Region: UPF0118; pfam01594
701521002289	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
701521002290	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
701521002291	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
701521002292	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
701521002293	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
701521002294	cell division protein MraZ; Reviewed; Region: PRK00326
701521002295	MraZ protein; Region: MraZ; pfam02381
701521002296	MraZ protein; Region: MraZ; pfam02381
701521002297	MraW methylase family; Region: Methyltransf_5; pfam01795
701521002298	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
701521002299	Cell division protein FtsL; Region: FtsL; cl11433
701521002300	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
701521002301	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
701521002302	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
701521002303	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
701521002304	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
701521002305	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
701521002306	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
701521002307	Mg++ binding site [ion binding]; other site
701521002308	putative catalytic motif [active]
701521002309	putative substrate binding site [chemical binding]; other site
701521002310	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
701521002311	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
701521002312	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
701521002313	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
701521002314	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
701521002315	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
701521002316	active site
701521002317	homodimer interface [polypeptide binding]; other site
701521002318	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
701521002319	Cell division protein FtsQ; Region: FtsQ; pfam03799
701521002320	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
701521002321	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
701521002322	nucleotide binding site [chemical binding]; other site
701521002323	SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491
701521002324	Cell division protein FtsA; Region: FtsA; pfam14450
701521002325	cell division protein FtsZ; Validated; Region: PRK09330
701521002326	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
701521002327	nucleotide binding site [chemical binding]; other site
701521002328	SulA interaction site; other site
701521002329	YGGT family; Region: YGGT; pfam02325
701521002330	Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302
701521002331	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
701521002332	RNA binding surface [nucleotide binding]; other site
701521002333	DivIVA protein; Region: DivIVA; pfam05103
701521002334	DivIVA domain; Region: DivI1A_domain; TIGR03544
701521002335	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
701521002336	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
701521002337	active site
701521002338	HIGH motif; other site
701521002339	nucleotide binding site [chemical binding]; other site
701521002340	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
701521002341	active site
701521002342	KMSKS motif; other site
701521002343	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
701521002344	tRNA binding surface [nucleotide binding]; other site
701521002345	anticodon binding site; other site
701521002346	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
701521002347	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
701521002348	DNA-binding site [nucleotide binding]; DNA binding site
701521002349	RNA-binding motif; other site
701521002350	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
701521002351	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
701521002352	dimer interface [polypeptide binding]; other site
701521002353	ADP-ribose binding site [chemical binding]; other site
701521002354	active site
701521002355	nudix motif; other site
701521002356	metal binding site [ion binding]; metal-binding site
701521002357	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
701521002358	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
701521002359	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
701521002360	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
701521002361	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
701521002362	catalytic residue [active]
701521002363	Putative amino acid metabolism; Region: DUF1831; pfam08866
701521002364	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
701521002365	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
701521002366	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
701521002367	catalytic core [active]
701521002368	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
701521002369	binding surface
701521002370	TPR motif; other site
701521002371	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
701521002372	AAA domain; Region: AAA_30; pfam13604
701521002373	Family description; Region: UvrD_C_2; pfam13538
701521002374	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269
701521002375	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
701521002376	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
701521002377	active site
701521002378	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
701521002379	DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411
701521002380	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
701521002381	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
701521002382	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
701521002383	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
701521002384	putative substrate binding site [chemical binding]; other site
701521002385	putative ATP binding site [chemical binding]; other site
701521002386	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
701521002387	active site
701521002388	phosphorylation site [posttranslational modification]
701521002389	putative PTS system  transporter subunits IIBC; Provisional; Region: PRK11404
701521002390	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
701521002391	active site
701521002392	P-loop; other site
701521002393	phosphorylation site [posttranslational modification]
701521002394	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
701521002395	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
701521002396	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
701521002397	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
701521002398	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
701521002399	NlpC/P60 family; Region: NLPC_P60; pfam00877
701521002400	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
701521002401	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
701521002402	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
701521002403	Protein of unknown function (DUF1447); Region: DUF1447; cl11492
701521002404	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
701521002405	active site
701521002406	catalytic residues [active]
701521002407	metal binding site [ion binding]; metal-binding site
701521002408	Uncharacterized protein family (UPF0223); Region: UPF0223; cl11484
701521002409	Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637
701521002410	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
701521002411	active site
701521002412	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
701521002413	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
701521002414	G1 box; other site
701521002415	putative GEF interaction site [polypeptide binding]; other site
701521002416	GTP/Mg2+ binding site [chemical binding]; other site
701521002417	Switch I region; other site
701521002418	G2 box; other site
701521002419	G3 box; other site
701521002420	Switch II region; other site
701521002421	G4 box; other site
701521002422	G5 box; other site
701521002423	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
701521002424	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
701521002425	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
701521002426	Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; cl11453
701521002427	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
701521002428	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
701521002429	S-adenosylmethionine binding site [chemical binding]; other site
701521002430	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
701521002431	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
701521002432	active site
701521002433	(T/H)XGH motif; other site
701521002434	Predicted secreted protein containing a PDZ domain [Signal transduction mechanisms]; Region: SdrC; COG3480
701521002435	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
701521002436	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
701521002437	SLBB domain; Region: SLBB; pfam10531
701521002438	comEA protein; Region: comE; TIGR01259
701521002439	Helix-hairpin-helix motif; Region: HHH; pfam00633
701521002440	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
701521002441	catalytic motif [active]
701521002442	Zn binding site [ion binding]; other site
701521002443	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
701521002444	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
701521002445	Competence protein; Region: Competence; pfam03772
701521002446	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
701521002447	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
701521002448	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
701521002449	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
701521002450	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
701521002451	16S/18S rRNA binding site [nucleotide binding]; other site
701521002452	S13e-L30e interaction site [polypeptide binding]; other site
701521002453	25S rRNA binding site [nucleotide binding]; other site
701521002454	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
701521002455	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
701521002456	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
701521002457	elongation factor Tu; Reviewed; Region: PRK00049
701521002458	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
701521002459	G1 box; other site
701521002460	GEF interaction site [polypeptide binding]; other site
701521002461	GTP/Mg2+ binding site [chemical binding]; other site
701521002462	Switch I region; other site
701521002463	G2 box; other site
701521002464	G3 box; other site
701521002465	Switch II region; other site
701521002466	G4 box; other site
701521002467	G5 box; other site
701521002468	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
701521002469	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
701521002470	Antibiotic Binding Site [chemical binding]; other site
701521002471	trigger factor; Provisional; Region: tig; PRK01490
701521002472	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
701521002473	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
701521002474	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
701521002475	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
701521002476	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
701521002477	Walker A motif; other site
701521002478	ATP binding site [chemical binding]; other site
701521002479	Walker B motif; other site
701521002480	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
701521002481	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
701521002482	G1 box; other site
701521002483	GTP/Mg2+ binding site [chemical binding]; other site
701521002484	Switch I region; other site
701521002485	G2 box; other site
701521002486	G3 box; other site
701521002487	Switch II region; other site
701521002488	G4 box; other site
701521002489	G5 box; other site
701521002490	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541
701521002491	putative metal binding site [ion binding]; other site
701521002492	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
701521002493	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
701521002494	substrate binding pocket [chemical binding]; other site
701521002495	membrane-bound complex binding site; other site
701521002496	hinge residues; other site
701521002497	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
701521002498	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
701521002499	dimer interface [polypeptide binding]; other site
701521002500	conserved gate region; other site
701521002501	putative PBP binding loops; other site
701521002502	ABC-ATPase subunit interface; other site
701521002503	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
701521002504	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
701521002505	Walker A/P-loop; other site
701521002506	ATP binding site [chemical binding]; other site
701521002507	Q-loop/lid; other site
701521002508	ABC transporter signature motif; other site
701521002509	Walker B; other site
701521002510	D-loop; other site
701521002511	H-loop/switch region; other site
701521002512	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
701521002513	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
701521002514	GIY-YIG motif/motif A; other site
701521002515	active site
701521002516	catalytic site [active]
701521002517	putative DNA binding site [nucleotide binding]; other site
701521002518	metal binding site [ion binding]; metal-binding site
701521002519	UvrB/uvrC motif; Region: UVR; pfam02151
701521002520	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
701521002521	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
701521002522	DNA binding site [nucleotide binding]
701521002523	GTPase CgtA; Reviewed; Region: obgE; PRK12297
701521002524	GTP1/OBG; Region: GTP1_OBG; pfam01018
701521002525	Obg GTPase; Region: Obg; cd01898
701521002526	G1 box; other site
701521002527	GTP/Mg2+ binding site [chemical binding]; other site
701521002528	Switch I region; other site
701521002529	G2 box; other site
701521002530	G3 box; other site
701521002531	Switch II region; other site
701521002532	G4 box; other site
701521002533	G5 box; other site
701521002534	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
701521002535	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
701521002536	yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840
701521002537	catalytic triad [active]
701521002538	catalytic triad [active]
701521002539	oxyanion hole [active]
701521002540	ribonuclease Z; Region: RNase_Z; TIGR02651
701521002541	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
701521002542	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
701521002543	NAD(P) binding site [chemical binding]; other site
701521002544	active site
701521002545	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
701521002546	DHH family; Region: DHH; pfam01368
701521002547	DHHA1 domain; Region: DHHA1; pfam02272
701521002548	Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; cl11538
701521002549	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
701521002550	active site
701521002551	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
701521002552	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
701521002553	amidase catalytic site [active]
701521002554	Zn binding residues [ion binding]; other site
701521002555	substrate binding site [chemical binding]; other site
701521002556	Bacterial SH3 domain; Region: SH3_5; pfam08460
701521002557	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
701521002558	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
701521002559	putative active site [active]
701521002560	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626
701521002561	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
701521002562	Host cell surface-exposed lipoprotein; Region: Lipoprotein_Ltp; pfam07553
701521002563	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
701521002564	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
701521002565	non-specific DNA binding site [nucleotide binding]; other site
701521002566	salt bridge; other site
701521002567	sequence-specific DNA binding site [nucleotide binding]; other site
701521002568	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
701521002569	amidase catalytic site [active]
701521002570	Zn binding residues [ion binding]; other site
701521002571	substrate binding site [chemical binding]; other site
701521002572	Bacterial SH3 domain; Region: SH3_5; pfam08460
701521002573	DNA primase, catalytic core; Region: dnaG; TIGR01391
701521002574	CHC2 zinc finger; Region: zf-CHC2; pfam01807
701521002575	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
701521002576	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
701521002577	active site
701521002578	metal binding site [ion binding]; metal-binding site
701521002579	interdomain interaction site; other site
701521002580	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
701521002581	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
701521002582	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
701521002583	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
701521002584	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
701521002585	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
701521002586	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
701521002587	DNA binding residues [nucleotide binding]
701521002588	Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384
701521002589	Family of unknown function (DUF633); Region: DUF633; pfam04816
701521002590	Uncharacterized conserved protein [Function unknown]; Region: COG0327
701521002591	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
701521002592	Protein of unknown function (DUF2929); Region: DUF2929; pfam11151
701521002593	DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587
701521002594	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431
701521002595	active site
701521002596	PHP Thumb interface [polypeptide binding]; other site
701521002597	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
701521002598	generic binding surface II; other site
701521002599	generic binding surface I; other site
701521002600	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
701521002601	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
701521002602	active site
701521002603	ADP/pyrophosphate binding site [chemical binding]; other site
701521002604	dimerization interface [polypeptide binding]; other site
701521002605	allosteric effector site; other site
701521002606	fructose-1,6-bisphosphate binding site; other site
701521002607	pyruvate kinase; Provisional; Region: PRK06354
701521002608	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
701521002609	domain interfaces; other site
701521002610	active site
701521002611	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
701521002612	Protein of unknown function (DUF441); Region: DUF441; pfam04284
701521002613	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
701521002614	S1 domain; Region: S1_2; pfam13509
701521002615	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
701521002616	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
701521002617	active site
701521002618	Int/Topo IB signature motif; other site
701521002619	segregation and condensation protein A; Reviewed; Region: scpA; PRK00104
701521002620	segregation and condensation protein B; Reviewed; Region: scpB; PRK00135
701521002621	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
701521002622	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
701521002623	RNA binding surface [nucleotide binding]; other site
701521002624	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
701521002625	active site
701521002626	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955
701521002627	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
701521002628	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
701521002629	ATP binding site [chemical binding]; other site
701521002630	putative Mg++ binding site [ion binding]; other site
701521002631	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
701521002632	nucleotide binding region [chemical binding]; other site
701521002633	ATP-binding site [chemical binding]; other site
701521002634	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
701521002635	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
701521002636	cytidylate kinase; Provisional; Region: cmk; PRK00023
701521002637	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
701521002638	CMP-binding site; other site
701521002639	The sites determining sugar specificity; other site
701521002640	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
701521002641	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
701521002642	RNA binding site [nucleotide binding]; other site
701521002643	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
701521002644	RNA binding site [nucleotide binding]; other site
701521002645	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
701521002646	RNA binding site [nucleotide binding]; other site
701521002647	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
701521002648	RNA binding site [nucleotide binding]; other site
701521002649	GTP-binding protein Der; Reviewed; Region: PRK00093
701521002650	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
701521002651	G1 box; other site
701521002652	GTP/Mg2+ binding site [chemical binding]; other site
701521002653	Switch I region; other site
701521002654	G2 box; other site
701521002655	Switch II region; other site
701521002656	G3 box; other site
701521002657	G4 box; other site
701521002658	G5 box; other site
701521002659	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
701521002660	G1 box; other site
701521002661	GTP/Mg2+ binding site [chemical binding]; other site
701521002662	Switch I region; other site
701521002663	G2 box; other site
701521002664	G3 box; other site
701521002665	Switch II region; other site
701521002666	G4 box; other site
701521002667	G5 box; other site
701521002668	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
701521002669	IHF dimer interface [polypeptide binding]; other site
701521002670	IHF - DNA interface [nucleotide binding]; other site
701521002671	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
701521002672	binding surface
701521002673	TPR motif; other site
701521002674	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
701521002675	binding surface
701521002676	TPR motif; other site
701521002677	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
701521002678	binding surface
701521002679	TPR motif; other site
701521002680	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014
701521002681	Uncharacterized conserved protein [Function unknown]; Region: COG1284
701521002682	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
701521002683	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
701521002684	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
701521002685	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299
701521002686	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
701521002687	active site
701521002688	NTP binding site [chemical binding]; other site
701521002689	metal binding triad [ion binding]; metal-binding site
701521002690	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
701521002691	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
701521002692	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
701521002693	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
701521002694	Walker A/P-loop; other site
701521002695	ATP binding site [chemical binding]; other site
701521002696	Q-loop/lid; other site
701521002697	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
701521002698	ABC transporter signature motif; other site
701521002699	Walker B; other site
701521002700	D-loop; other site
701521002701	ABC transporter; Region: ABC_tran_2; pfam12848
701521002702	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
701521002703	thymidylate synthase; Region: thym_sym; TIGR03284
701521002704	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
701521002705	dimerization interface [polypeptide binding]; other site
701521002706	active site
701521002707	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
701521002708	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
701521002709	folate binding site [chemical binding]; other site
701521002710	NADP+ binding site [chemical binding]; other site
701521002711	EDD domain protein, DegV family; Region: DegV; TIGR00762
701521002712	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
701521002713	hypothetical protein; Provisional; Region: PRK13672
701521002714	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
701521002715	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
701521002716	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
701521002717	protein binding site [polypeptide binding]; other site
701521002718	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
701521002719	Catalytic dyad [active]
701521002720	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
701521002721	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
701521002722	active site
701521002723	catalytic triad [active]
701521002724	oxyanion hole [active]
701521002725	Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; cl11548
701521002726	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
701521002727	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
701521002728	GTP/Mg2+ binding site [chemical binding]; other site
701521002729	G4 box; other site
701521002730	G5 box; other site
701521002731	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
701521002732	G1 box; other site
701521002733	G1 box; other site
701521002734	GTP/Mg2+ binding site [chemical binding]; other site
701521002735	Switch I region; other site
701521002736	G2 box; other site
701521002737	G2 box; other site
701521002738	Switch I region; other site
701521002739	G3 box; other site
701521002740	G3 box; other site
701521002741	Switch II region; other site
701521002742	Switch II region; other site
701521002743	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
701521002744	RNA/DNA hybrid binding site [nucleotide binding]; other site
701521002745	active site
701521002746	DNA protecting protein DprA; Region: dprA; TIGR00732
701521002747	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
701521002748	DNA topoisomerase I; Validated; Region: PRK05582
701521002749	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
701521002750	active site
701521002751	interdomain interaction site; other site
701521002752	putative metal-binding site [ion binding]; other site
701521002753	nucleotide binding site [chemical binding]; other site
701521002754	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
701521002755	domain I; other site
701521002756	DNA binding groove [nucleotide binding]
701521002757	phosphate binding site [ion binding]; other site
701521002758	domain II; other site
701521002759	domain III; other site
701521002760	nucleotide binding site [chemical binding]; other site
701521002761	catalytic site [active]
701521002762	domain IV; other site
701521002763	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
701521002764	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
701521002765	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
701521002766	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
701521002767	active site
701521002768	DNA binding site [nucleotide binding]
701521002769	Int/Topo IB signature motif; other site
701521002770	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
701521002771	active site
701521002772	HslU subunit interaction site [polypeptide binding]; other site
701521002773	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
701521002774	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
701521002775	Walker A motif; other site
701521002776	ATP binding site [chemical binding]; other site
701521002777	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
701521002778	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
701521002779	Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024
701521002780	active site
701521002781	catalytic residues [active]
701521002782	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
701521002783	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
701521002784	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
701521002785	ATP binding site [chemical binding]; other site
701521002786	Mg2+ binding site [ion binding]; other site
701521002787	G-X-G motif; other site
701521002788	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
701521002789	anchoring element; other site
701521002790	dimer interface [polypeptide binding]; other site
701521002791	ATP binding site [chemical binding]; other site
701521002792	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
701521002793	active site
701521002794	putative metal-binding site [ion binding]; other site
701521002795	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
701521002796	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
701521002797	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
701521002798	CAP-like domain; other site
701521002799	active site
701521002800	primary dimer interface [polypeptide binding]; other site
701521002801	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
701521002802	Transcriptional regulator [Transcription]; Region: LysR; COG0583
701521002803	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
701521002804	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
701521002805	dimerization interface [polypeptide binding]; other site
701521002806	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
701521002807	DHH family; Region: DHH; pfam01368
701521002808	DHHA2 domain; Region: DHHA2; pfam02833
701521002809	methionine sulfoxide reductase B; Provisional; Region: PRK00222
701521002810	SelR domain; Region: SelR; pfam01641
701521002811	methionine sulfoxide reductase A; Provisional; Region: PRK14054
701521002812	inner membrane transporter YjeM; Provisional; Region: PRK15238
701521002813	Protein of unknown function (DUF1516); Region: DUF1516; cl11654
701521002814	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
701521002815	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
701521002816	catalytic triad [active]
701521002817	amino acid transporter; Region: 2A0306; TIGR00909
701521002818	Spore germination protein; Region: Spore_permease; cl17796
701521002819	CrcB-like protein; Region: CRCB; cl09114
701521002820	Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239
701521002821	EDD domain protein, DegV family; Region: DegV; TIGR00762
701521002822	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
701521002823	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
701521002824	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
701521002825	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
701521002826	Domain of unknown function (DUF814); Region: DUF814; pfam05670
701521002827	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
701521002828	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
701521002829	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
701521002830	dimer interface [polypeptide binding]; other site
701521002831	motif 1; other site
701521002832	active site
701521002833	motif 2; other site
701521002834	motif 3; other site
701521002835	DNA repair protein RecO; Region: reco; TIGR00613
701521002836	Recombination protein O N terminal; Region: RecO_N; pfam11967
701521002837	Recombination protein O C terminal; Region: RecO_C; pfam02565
701521002838	GTPase Era; Reviewed; Region: era; PRK00089
701521002839	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
701521002840	G1 box; other site
701521002841	GTP/Mg2+ binding site [chemical binding]; other site
701521002842	Switch I region; other site
701521002843	G2 box; other site
701521002844	Switch II region; other site
701521002845	G3 box; other site
701521002846	G4 box; other site
701521002847	G5 box; other site
701521002848	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
701521002849	metal-binding heat shock protein; Provisional; Region: PRK00016
701521002850	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
701521002851	PhoH-like protein; Region: PhoH; pfam02562
701521002852	Yqey-like protein; Region: YqeY; pfam09424
701521002853	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
701521002854	Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618
701521002855	endonuclease IV; Provisional; Region: PRK01060
701521002856	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
701521002857	AP (apurinic/apyrimidinic) site pocket; other site
701521002858	DNA interaction; other site
701521002859	Metal-binding active site; metal-binding site
701521002860	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
701521002861	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
701521002862	Uncharacterized conserved protein [Function unknown]; Region: COG1284
701521002863	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
701521002864	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
701521002865	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
701521002866	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
701521002867	dimer interface [polypeptide binding]; other site
701521002868	anticodon binding site; other site
701521002869	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
701521002870	homodimer interface [polypeptide binding]; other site
701521002871	motif 1; other site
701521002872	active site
701521002873	motif 2; other site
701521002874	GAD domain; Region: GAD; pfam02938
701521002875	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
701521002876	active site
701521002877	motif 3; other site
701521002878	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
701521002879	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
701521002880	dimer interface [polypeptide binding]; other site
701521002881	motif 1; other site
701521002882	active site
701521002883	motif 2; other site
701521002884	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
701521002885	anticodon binding site; other site
701521002886	Bacterial SH3 domain homologues; Region: SH3b; smart00287
701521002887	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
701521002888	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
701521002889	active site
701521002890	metal binding site [ion binding]; metal-binding site
701521002891	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
701521002892	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
701521002893	motif II; other site
701521002894	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
701521002895	putative active site [active]
701521002896	dimerization interface [polypeptide binding]; other site
701521002897	putative tRNAtyr binding site [nucleotide binding]; other site
701521002898	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
701521002899	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
701521002900	Zn2+ binding site [ion binding]; other site
701521002901	Mg2+ binding site [ion binding]; other site
701521002902	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
701521002903	synthetase active site [active]
701521002904	NTP binding site [chemical binding]; other site
701521002905	metal binding site [ion binding]; metal-binding site
701521002906	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
701521002907	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
701521002908	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
701521002909	RNA methyltransferase, RsmE family; Region: TIGR00046
701521002910	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
701521002911	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
701521002912	S-adenosylmethionine binding site [chemical binding]; other site
701521002913	uracil transporter; Provisional; Region: PRK10720
701521002914	GTP-binding protein LepA; Provisional; Region: PRK05433
701521002915	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
701521002916	G1 box; other site
701521002917	putative GEF interaction site [polypeptide binding]; other site
701521002918	GTP/Mg2+ binding site [chemical binding]; other site
701521002919	Switch I region; other site
701521002920	G2 box; other site
701521002921	G3 box; other site
701521002922	Switch II region; other site
701521002923	G4 box; other site
701521002924	G5 box; other site
701521002925	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
701521002926	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
701521002927	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
701521002928	chaperone protein DnaJ; Provisional; Region: PRK14276
701521002929	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
701521002930	HSP70 interaction site [polypeptide binding]; other site
701521002931	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
701521002932	substrate binding site [polypeptide binding]; other site
701521002933	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
701521002934	Zn binding sites [ion binding]; other site
701521002935	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
701521002936	substrate binding site [polypeptide binding]; other site
701521002937	dimer interface [polypeptide binding]; other site
701521002938	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
701521002939	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
701521002940	nucleotide binding site [chemical binding]; other site
701521002941	NEF interaction site [polypeptide binding]; other site
701521002942	SBD interface [polypeptide binding]; other site
701521002943	GrpE; Region: GrpE; pfam01025
701521002944	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
701521002945	dimer interface [polypeptide binding]; other site
701521002946	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
701521002947	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
701521002948	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
701521002949	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
701521002950	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
701521002951	active site
701521002952	Riboflavin kinase; Region: Flavokinase; smart00904
701521002953	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550
701521002954	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
701521002955	RNA binding site [nucleotide binding]; other site
701521002956	active site
701521002957	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
701521002958	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
701521002959	translation initiation factor IF-2; Region: IF-2; TIGR00487
701521002960	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
701521002961	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
701521002962	G1 box; other site
701521002963	putative GEF interaction site [polypeptide binding]; other site
701521002964	GTP/Mg2+ binding site [chemical binding]; other site
701521002965	Switch I region; other site
701521002966	G2 box; other site
701521002967	G3 box; other site
701521002968	Switch II region; other site
701521002969	G4 box; other site
701521002970	G5 box; other site
701521002971	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
701521002972	Translation-initiation factor 2; Region: IF-2; pfam11987
701521002973	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
701521002974	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
701521002975	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
701521002976	putative RNA binding cleft [nucleotide binding]; other site
701521002977	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
701521002978	NusA N-terminal domain; Region: NusA_N; pfam08529
701521002979	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
701521002980	RNA binding site [nucleotide binding]; other site
701521002981	homodimer interface [polypeptide binding]; other site
701521002982	NusA-like KH domain; Region: KH_5; pfam13184
701521002983	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
701521002984	G-X-X-G motif; other site
701521002985	ribosome maturation protein RimP; Reviewed; Region: PRK00092
701521002986	Sm and related proteins; Region: Sm_like; cl00259
701521002987	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
701521002988	putative oligomer interface [polypeptide binding]; other site
701521002989	putative RNA binding site [nucleotide binding]; other site
701521002990	DNA polymerase III PolC; Validated; Region: polC; PRK00448
701521002991	DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490
701521002992	polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484
701521002993	generic binding surface I; other site
701521002994	generic binding surface II; other site
701521002995	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
701521002996	active site
701521002997	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
701521002998	active site
701521002999	catalytic site [active]
701521003000	substrate binding site [chemical binding]; other site
701521003001	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
701521003002	prolyl-tRNA synthetase; Provisional; Region: PRK09194
701521003003	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
701521003004	dimer interface [polypeptide binding]; other site
701521003005	motif 1; other site
701521003006	active site
701521003007	motif 2; other site
701521003008	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
701521003009	putative deacylase active site [active]
701521003010	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
701521003011	active site
701521003012	motif 3; other site
701521003013	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
701521003014	anticodon binding site; other site
701521003015	RIP metalloprotease RseP; Region: TIGR00054
701521003016	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
701521003017	active site
701521003018	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
701521003019	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
701521003020	protein binding site [polypeptide binding]; other site
701521003021	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
701521003022	putative substrate binding region [chemical binding]; other site
701521003023	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
701521003024	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
701521003025	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
701521003026	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
701521003027	catalytic residue [active]
701521003028	putative FPP diphosphate  binding site; other site
701521003029	putative FPP binding hydrophobic cleft; other site
701521003030	dimer interface [polypeptide binding]; other site
701521003031	putative IPP diphosphate binding site; other site
701521003032	ribosome recycling factor; Reviewed; Region: frr; PRK00083
701521003033	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
701521003034	hinge region; other site
701521003035	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
701521003036	putative nucleotide binding site [chemical binding]; other site
701521003037	uridine monophosphate binding site [chemical binding]; other site
701521003038	homohexameric interface [polypeptide binding]; other site
701521003039	elongation factor Ts; Provisional; Region: tsf; PRK09377
701521003040	UBA/TS-N domain; Region: UBA; pfam00627
701521003041	Elongation factor TS; Region: EF_TS; pfam00889
701521003042	Elongation factor TS; Region: EF_TS; pfam00889
701521003043	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
701521003044	rRNA interaction site [nucleotide binding]; other site
701521003045	S8 interaction site; other site
701521003046	putative laminin-1 binding site; other site
701521003047	D-lactate dehydrogenase; Validated; Region: PRK08605
701521003048	D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186
701521003049	homodimer interface [polypeptide binding]; other site
701521003050	ligand binding site [chemical binding]; other site
701521003051	NAD binding site [chemical binding]; other site
701521003052	catalytic site [active]
701521003053	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
701521003054	GIY-YIG motif/motif A; other site
701521003055	putative active site [active]
701521003056	putative metal binding site [ion binding]; other site
701521003057	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
701521003058	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
701521003059	S-adenosylmethionine binding site [chemical binding]; other site
701521003060	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
701521003061	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
701521003062	putative acyl-acceptor binding pocket; other site
701521003063	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763
701521003064	Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979
701521003065	LexA repressor; Validated; Region: PRK00215
701521003066	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
701521003067	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
701521003068	Catalytic site [active]
701521003069	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
701521003070	3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835
701521003071	dimer interface [polypeptide binding]; other site
701521003072	active site
701521003073	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
701521003074	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
701521003075	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
701521003076	Walker A/P-loop; other site
701521003077	ATP binding site [chemical binding]; other site
701521003078	Q-loop/lid; other site
701521003079	ABC transporter signature motif; other site
701521003080	Walker B; other site
701521003081	D-loop; other site
701521003082	H-loop/switch region; other site
701521003083	Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458
701521003084	ATP-grasp domain; Region: ATP-grasp_4; cl17255
701521003085	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
701521003086	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096
701521003087	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
701521003088	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
701521003089	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
701521003090	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
701521003091	catalytic site [active]
701521003092	subunit interface [polypeptide binding]; other site
701521003093	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
701521003094	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
701521003095	active site
701521003096	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
701521003097	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
701521003098	RNA binding surface [nucleotide binding]; other site
701521003099	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
701521003100	active site
701521003101	lipoprotein signal peptidase; Provisional; Region: PRK14787
701521003102	lipoprotein signal peptidase; Provisional; Region: PRK14797
701521003103	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
701521003104	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
701521003105	Potassium binding sites [ion binding]; other site
701521003106	Cesium cation binding sites [ion binding]; other site
701521003107	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
701521003108	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
701521003109	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
701521003110	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
701521003111	cell division protein GpsB; Provisional; Region: PRK14127
701521003112	DivIVA domain; Region: DivI1A_domain; TIGR03544
701521003113	hypothetical protein; Provisional; Region: PRK13660
701521003114	Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234
701521003115	Membrane carboxypeptidase (penicillin-binding protein) [Cell envelope biogenesis, outer membrane]; Region: MrcB; COG0744
701521003116	Transglycosylase; Region: Transgly; pfam00912
701521003117	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
701521003118	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
701521003119	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
701521003120	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
701521003121	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
701521003122	putative dimer interface [polypeptide binding]; other site
701521003123	putative anticodon binding site; other site
701521003124	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
701521003125	homodimer interface [polypeptide binding]; other site
701521003126	motif 1; other site
701521003127	motif 2; other site
701521003128	active site
701521003129	motif 3; other site
701521003130	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353
701521003131	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074
701521003132	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
701521003133	active site
701521003134	catalytic site [active]
701521003135	substrate binding site [chemical binding]; other site
701521003136	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
701521003137	ATP binding site [chemical binding]; other site
701521003138	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
701521003139	mevalonate kinase; Region: mevalon_kin; TIGR00549
701521003140	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
701521003141	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
701521003142	Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407
701521003143	diphosphomevalonate decarboxylase; Region: PLN02407
701521003144	phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220
701521003145	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
701521003146	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
701521003147	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
701521003148	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
701521003149	homotetramer interface [polypeptide binding]; other site
701521003150	FMN binding site [chemical binding]; other site
701521003151	homodimer contacts [polypeptide binding]; other site
701521003152	putative active site [active]
701521003153	putative substrate binding site [chemical binding]; other site
701521003154	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
701521003155	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
701521003156	S-adenosylmethionine binding site [chemical binding]; other site
701521003157	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
701521003158	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
701521003159	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
701521003160	active site
701521003161	motif I; other site
701521003162	motif II; other site
701521003163	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
701521003164	4-oxalocrotonate tautomerase; Provisional; Region: PRK02220
701521003165	active site 1 [active]
701521003166	dimer interface [polypeptide binding]; other site
701521003167	hexamer interface [polypeptide binding]; other site
701521003168	active site 2 [active]
701521003169	Peptidase family C69; Region: Peptidase_C69; pfam03577
701521003170	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
701521003171	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
701521003172	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
701521003173	RimM N-terminal domain; Region: RimM; pfam01782
701521003174	PRC-barrel domain; Region: PRC; pfam05239
701521003175	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
701521003176	signal recognition particle protein; Provisional; Region: PRK10867
701521003177	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
701521003178	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
701521003179	GTP binding site [chemical binding]; other site
701521003180	Signal peptide binding domain; Region: SRP_SPB; pfam02978
701521003181	putative DNA-binding protein; Validated; Region: PRK00118
701521003182	Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297
701521003183	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
701521003184	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
701521003185	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
701521003186	P loop; other site
701521003187	GTP binding site [chemical binding]; other site
701521003188	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
701521003189	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
701521003190	Walker A/P-loop; other site
701521003191	ATP binding site [chemical binding]; other site
701521003192	Q-loop/lid; other site
701521003193	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
701521003194	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
701521003195	ABC transporter signature motif; other site
701521003196	Walker B; other site
701521003197	D-loop; other site
701521003198	H-loop/switch region; other site
701521003199	ribonuclease III; Reviewed; Region: rnc; PRK00102
701521003200	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
701521003201	dimerization interface [polypeptide binding]; other site
701521003202	active site
701521003203	metal binding site [ion binding]; metal-binding site
701521003204	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
701521003205	dsRNA binding site [nucleotide binding]; other site
701521003206	acyl carrier protein; Provisional; Region: acpP; PRK00982
701521003207	putative phosphate acyltransferase; Provisional; Region: PRK05331
701521003208	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
701521003209	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
701521003210	generic binding surface II; other site
701521003211	ssDNA binding site; other site
701521003212	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
701521003213	ATP binding site [chemical binding]; other site
701521003214	putative Mg++ binding site [ion binding]; other site
701521003215	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
701521003216	nucleotide binding region [chemical binding]; other site
701521003217	ATP-binding site [chemical binding]; other site
701521003218	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
701521003219	DAK2 domain; Region: Dak2; pfam02734
701521003220	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302
701521003221	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
701521003222	Thiamine pyrophosphokinase; Region: TPK; cd07995
701521003223	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
701521003224	active site
701521003225	dimerization interface [polypeptide binding]; other site
701521003226	thiamine binding site [chemical binding]; other site
701521003227	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
701521003228	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
701521003229	substrate binding site [chemical binding]; other site
701521003230	hexamer interface [polypeptide binding]; other site
701521003231	metal binding site [ion binding]; metal-binding site
701521003232	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
701521003233	GTPase RsgA; Reviewed; Region: PRK00098
701521003234	RNA binding site [nucleotide binding]; other site
701521003235	homodimer interface [polypeptide binding]; other site
701521003236	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
701521003237	GTPase/Zn-binding domain interface [polypeptide binding]; other site
701521003238	GTP/Mg2+ binding site [chemical binding]; other site
701521003239	G4 box; other site
701521003240	G5 box; other site
701521003241	G1 box; other site
701521003242	Switch I region; other site
701521003243	G2 box; other site
701521003244	G3 box; other site
701521003245	Switch II region; other site
701521003246	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
701521003247	Catalytic domain of Protein Kinases; Region: PKc; cd00180
701521003248	active site
701521003249	ATP binding site [chemical binding]; other site
701521003250	substrate binding site [chemical binding]; other site
701521003251	activation loop (A-loop); other site
701521003252	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
701521003253	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
701521003254	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
701521003255	active site
701521003256	16S rRNA methyltransferase B; Provisional; Region: PRK14902
701521003257	NusB family; Region: NusB; pfam01029
701521003258	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
701521003259	S-adenosylmethionine binding site [chemical binding]; other site
701521003260	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
701521003261	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
701521003262	putative active site [active]
701521003263	substrate binding site [chemical binding]; other site
701521003264	putative cosubstrate binding site; other site
701521003265	catalytic site [active]
701521003266	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
701521003267	substrate binding site [chemical binding]; other site
701521003268	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
701521003269	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
701521003270	ATP binding site [chemical binding]; other site
701521003271	putative Mg++ binding site [ion binding]; other site
701521003272	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
701521003273	nucleotide binding region [chemical binding]; other site
701521003274	ATP-binding site [chemical binding]; other site
701521003275	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
701521003276	Flavoprotein; Region: Flavoprotein; pfam02441
701521003277	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
701521003278	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
701521003279	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
701521003280	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
701521003281	catalytic site [active]
701521003282	G-X2-G-X-G-K; other site
701521003283	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
701521003284	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
701521003285	Walker A/P-loop; other site
701521003286	ATP binding site [chemical binding]; other site
701521003287	Q-loop/lid; other site
701521003288	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
701521003289	ABC transporter signature motif; other site
701521003290	Walker B; other site
701521003291	D-loop; other site
701521003292	H-loop/switch region; other site
701521003293	Arginine repressor [Transcription]; Region: ArgR; COG1438
701521003294	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
701521003295	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
701521003296	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
701521003297	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
701521003298	RNA binding surface [nucleotide binding]; other site
701521003299	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
701521003300	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
701521003301	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
701521003302	substrate binding pocket [chemical binding]; other site
701521003303	chain length determination region; other site
701521003304	substrate-Mg2+ binding site; other site
701521003305	catalytic residues [active]
701521003306	aspartate-rich region 1; other site
701521003307	active site lid residues [active]
701521003308	aspartate-rich region 2; other site
701521003309	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
701521003310	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
701521003311	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
701521003312	generic binding surface II; other site
701521003313	generic binding surface I; other site
701521003314	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190
701521003315	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
701521003316	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
701521003317	homodimer interface [polypeptide binding]; other site
701521003318	NADP binding site [chemical binding]; other site
701521003319	substrate binding site [chemical binding]; other site
701521003320	transcription antitermination factor NusB; Region: nusB; TIGR01951
701521003321	putative RNA binding site [nucleotide binding]; other site
701521003322	Asp23 family; Region: Asp23; pfam03780
701521003323	elongation factor P; Validated; Region: PRK00529
701521003324	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
701521003325	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
701521003326	RNA binding site [nucleotide binding]; other site
701521003327	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
701521003328	RNA binding site [nucleotide binding]; other site
701521003329	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
701521003330	Protein of unknown function (DUF464); Region: DUF464; pfam04327
701521003331	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
701521003332	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
701521003333	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
701521003334	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
701521003335	Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083
701521003336	LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167
701521003337	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
701521003338	Mycoplasma protein of unknown function, DUF285; Region: DUF285; pfam03382
701521003339	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
701521003340	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
701521003341	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
701521003342	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
701521003343	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
701521003344	bacterial surface protein 26-residue repeat; Region: Liste_lipo_26; TIGR02167
701521003345	Protein of unknown function (DUF805); Region: DUF805; pfam05656
701521003346	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
701521003347	dihydropteroate synthase; Region: DHPS; TIGR01496
701521003348	substrate binding pocket [chemical binding]; other site
701521003349	dimer interface [polypeptide binding]; other site
701521003350	inhibitor binding site; inhibition site
701521003351	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
701521003352	active site
701521003353	dimerization interface [polypeptide binding]; other site
701521003354	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
701521003355	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
701521003356	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
701521003357	GTP cyclohydrolase I; Provisional; Region: PLN03044
701521003358	active site
701521003359	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
701521003360	catalytic center binding site [active]
701521003361	ATP binding site [chemical binding]; other site
701521003362	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
701521003363	homooctamer interface [polypeptide binding]; other site
701521003364	active site
701521003365	dUTPase; Region: dUTPase_2; pfam08761
701521003366	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527
701521003367	active site
701521003368	homodimer interface [polypeptide binding]; other site
701521003369	metal binding site [ion binding]; metal-binding site
701521003370	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
701521003371	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
701521003372	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
701521003373	Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105
701521003374	DNA binding residues [nucleotide binding]
701521003375	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
701521003376	putative dimer interface [polypeptide binding]; other site
701521003377	Aluminium resistance protein; Region: Alum_res; pfam06838
701521003378	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
701521003379	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
701521003380	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
701521003381	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
701521003382	Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563
701521003383	active site
701521003384	catalytic site [active]
701521003385	metal binding site [ion binding]; metal-binding site
701521003386	dimer interface [polypeptide binding]; other site
701521003387	Protein of unknown function (DUF3042); Region: DUF3042; pfam11240
701521003388	DNA topoisomerase III; Provisional; Region: PRK07726
701521003389	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
701521003390	active site
701521003391	putative interdomain interaction site [polypeptide binding]; other site
701521003392	putative metal-binding site [ion binding]; other site
701521003393	putative nucleotide binding site [chemical binding]; other site
701521003394	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
701521003395	domain I; other site
701521003396	DNA binding groove [nucleotide binding]
701521003397	phosphate binding site [ion binding]; other site
701521003398	domain II; other site
701521003399	domain III; other site
701521003400	nucleotide binding site [chemical binding]; other site
701521003401	catalytic site [active]
701521003402	domain IV; other site
701521003403	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
701521003404	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
701521003405	active site residue [active]
701521003406	ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744
701521003407	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
701521003408	nucleotide binding site [chemical binding]; other site
701521003409	Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014
701521003410	Rhomboid family; Region: Rhomboid; pfam01694
701521003411	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
701521003412	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
701521003413	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
701521003414	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
701521003415	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
701521003416	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
701521003417	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
701521003418	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
701521003419	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
701521003420	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
701521003421	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
701521003422	Sugar specificity; other site
701521003423	Pyrimidine base specificity; other site
701521003424	ATP-binding site [chemical binding]; other site
701521003425	YceG-like family; Region: YceG; pfam02618
701521003426	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
701521003427	dimerization interface [polypeptide binding]; other site
701521003428	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
701521003429	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
701521003430	putative tRNA-binding site [nucleotide binding]; other site
701521003431	B3/4 domain; Region: B3_4; pfam03483
701521003432	tRNA synthetase B5 domain; Region: B5; smart00874
701521003433	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
701521003434	dimer interface [polypeptide binding]; other site
701521003435	motif 1; other site
701521003436	motif 3; other site
701521003437	motif 2; other site
701521003438	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
701521003439	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
701521003440	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
701521003441	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
701521003442	dimer interface [polypeptide binding]; other site
701521003443	motif 1; other site
701521003444	active site
701521003445	motif 2; other site
701521003446	motif 3; other site
701521003447	Predicted transcriptional regulators [Transcription]; Region: COG1733
701521003448	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
701521003449	HD domain; Region: HD; pfam01966
701521003450	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
701521003451	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
701521003452	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
701521003453	Acylphosphatase; Region: Acylphosphatase; pfam00708
701521003454	OxaA-like protein precursor; Provisional; Region: PRK02463
701521003455	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
701521003456	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
701521003457	HAMP domain; Region: HAMP; pfam00672
701521003458	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
701521003459	dimer interface [polypeptide binding]; other site
701521003460	phosphorylation site [posttranslational modification]
701521003461	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
701521003462	ATP binding site [chemical binding]; other site
701521003463	Mg2+ binding site [ion binding]; other site
701521003464	G-X-G motif; other site
701521003465	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
701521003466	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
701521003467	active site
701521003468	phosphorylation site [posttranslational modification]
701521003469	intermolecular recognition site; other site
701521003470	dimerization interface [polypeptide binding]; other site
701521003471	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
701521003472	DNA binding site [nucleotide binding]
701521003473	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
701521003474	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
701521003475	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
701521003476	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
701521003477	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
701521003478	hypothetical protein; Provisional; Region: PRK13670
701521003479	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
701521003480	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
701521003481	S-adenosylmethionine binding site [chemical binding]; other site
701521003482	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
701521003483	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
701521003484	Zn2+ binding site [ion binding]; other site
701521003485	Mg2+ binding site [ion binding]; other site
701521003486	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
701521003487	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
701521003488	active site
701521003489	(T/H)XGH motif; other site
701521003490	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; pfam01985
701521003491	GTPase YqeH; Provisional; Region: PRK13796
701521003492	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
701521003493	GTP/Mg2+ binding site [chemical binding]; other site
701521003494	G4 box; other site
701521003495	G5 box; other site
701521003496	G1 box; other site
701521003497	Switch I region; other site
701521003498	G2 box; other site
701521003499	G3 box; other site
701521003500	Switch II region; other site
701521003501	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
701521003502	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
701521003503	active site
701521003504	motif I; other site
701521003505	motif II; other site
701521003506	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
701521003507	alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289
701521003508	putative NAD(P) binding site [chemical binding]; other site
701521003509	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
701521003510	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
701521003511	23S rRNA binding site [nucleotide binding]; other site
701521003512	L21 binding site [polypeptide binding]; other site
701521003513	L13 binding site [polypeptide binding]; other site
701521003514	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
701521003515	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
701521003516	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
701521003517	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
701521003518	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
701521003519	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
701521003520	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
701521003521	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
701521003522	active site
701521003523	dimer interface [polypeptide binding]; other site
701521003524	motif 1; other site
701521003525	motif 2; other site
701521003526	motif 3; other site
701521003527	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
701521003528	anticodon binding site; other site
701521003529	primosomal protein DnaI; Reviewed; Region: PRK08939
701521003530	Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319
701521003531	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
701521003532	Walker A motif; other site
701521003533	ATP binding site [chemical binding]; other site
701521003534	Walker B motif; other site
701521003535	Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611
701521003536	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
701521003537	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
701521003538	ATP cone domain; Region: ATP-cone; pfam03477
701521003539	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
701521003540	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
701521003541	CoA-binding site [chemical binding]; other site
701521003542	ATP-binding [chemical binding]; other site
701521003543	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
701521003544	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
701521003545	DNA binding site [nucleotide binding]
701521003546	catalytic residue [active]
701521003547	H2TH interface [polypeptide binding]; other site
701521003548	putative catalytic residues [active]
701521003549	turnover-facilitating residue; other site
701521003550	intercalation triad [nucleotide binding]; other site
701521003551	8OG recognition residue [nucleotide binding]; other site
701521003552	putative reading head residues; other site
701521003553	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
701521003554	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
701521003555	DNA polymerase I; Provisional; Region: PRK05755
701521003556	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
701521003557	active site
701521003558	metal binding site 1 [ion binding]; metal-binding site
701521003559	putative 5' ssDNA interaction site; other site
701521003560	metal binding site 3; metal-binding site
701521003561	metal binding site 2 [ion binding]; metal-binding site
701521003562	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
701521003563	putative DNA binding site [nucleotide binding]; other site
701521003564	putative metal binding site [ion binding]; other site
701521003565	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
701521003566	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
701521003567	active site
701521003568	DNA binding site [nucleotide binding]
701521003569	catalytic site [active]
701521003570	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
701521003571	catalytic residues [active]
701521003572	dimer interface [polypeptide binding]; other site
701521003573	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
701521003574	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
701521003575	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
701521003576	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
701521003577	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
701521003578	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
701521003579	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
701521003580	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
701521003581	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
701521003582	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
701521003583	putative tRNA-binding site [nucleotide binding]; other site
701521003584	Predicted small secreted protein [Function unknown]; Region: COG5584
701521003585	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
701521003586	S-adenosylmethionine binding site [chemical binding]; other site
701521003587	Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975
701521003588	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
701521003589	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
701521003590	Walker A/P-loop; other site
701521003591	ATP binding site [chemical binding]; other site
701521003592	Q-loop/lid; other site
701521003593	ABC transporter signature motif; other site
701521003594	Walker B; other site
701521003595	D-loop; other site
701521003596	H-loop/switch region; other site
701521003597	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
701521003598	HIT family signature motif; other site
701521003599	catalytic residue [active]
701521003600	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
701521003601	peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405
701521003602	SurA N-terminal domain; Region: SurA_N_3; cl07813
701521003603	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
701521003604	3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480
701521003605	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
701521003606	generic binding surface I; other site
701521003607	generic binding surface II; other site
701521003608	integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760
701521003609	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
701521003610	Zn2+ binding site [ion binding]; other site
701521003611	Mg2+ binding site [ion binding]; other site
701521003612	AAA domain; Region: AAA_23; pfam13476
701521003613	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
701521003614	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
701521003615	active site
701521003616	metal binding site [ion binding]; metal-binding site
701521003617	DNA binding site [nucleotide binding]
701521003618	hypothetical protein; Provisional; Region: PRK13676
701521003619	Transglycosylase; Region: Transgly; pfam00912
701521003620	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
701521003621	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
701521003622	Arginine repressor [Transcription]; Region: ArgR; COG1438
701521003623	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
701521003624	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
701521003625	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
701521003626	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
701521003627	ligand binding site [chemical binding]; other site
701521003628	flexible hinge region; other site
701521003629	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320
701521003630	arginyl-tRNA synthetase; Reviewed; Region: PRK12451
701521003631	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
701521003632	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
701521003633	active site
701521003634	HIGH motif; other site
701521003635	KMSK motif region; other site
701521003636	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
701521003637	tRNA binding surface [nucleotide binding]; other site
701521003638	anticodon binding site; other site
701521003639	Integral membrane protein DUF95; Region: DUF95; cl00572
701521003640	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
701521003641	This family is most closely related to the GT1 family of glycosyltransferases. AmSD in Erwinia amylovora has been shown to be involved in the biosynthesis of amylovoran, the acidic exopolysaccharide acting as a virulence factor. This enzyme may be...; Region: GT1_amsD_like; cd03820
701521003642	putative ADP-binding pocket [chemical binding]; other site
701521003643	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
701521003644	aspartate racemase; Region: asp_race; TIGR00035
701521003645	Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919
701521003646	ATP-grasp domain; Region: ATP-grasp_4; pfam13535
701521003647	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
701521003648	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
701521003649	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
701521003650	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
701521003651	exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108
701521003652	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
701521003653	active site
701521003654	dimer interface [polypeptide binding]; other site
701521003655	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
701521003656	Ligand Binding Site [chemical binding]; other site
701521003657	Molecular Tunnel; other site
701521003658	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
701521003659	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
701521003660	glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910
701521003661	serine O-acetyltransferase; Region: cysE; TIGR01172
701521003662	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
701521003663	active site
701521003664	substrate binding site [chemical binding]; other site
701521003665	trimer interface [polypeptide binding]; other site
701521003666	CoA binding site [chemical binding]; other site
701521003667	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
701521003668	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
701521003669	dimer interface [polypeptide binding]; other site
701521003670	pyridoxal 5'-phosphate binding site [chemical binding]; other site
701521003671	catalytic residue [active]
701521003672	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
701521003673	DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626
701521003674	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
701521003675	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
701521003676	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
701521003677	active site
701521003678	motif I; other site
701521003679	motif II; other site
701521003680	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
701521003681	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
701521003682	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
701521003683	Substrate-binding site [chemical binding]; other site
701521003684	Substrate specificity [chemical binding]; other site
701521003685	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
701521003686	Ligand Binding Site [chemical binding]; other site
701521003687	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
701521003688	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
701521003689	RNA binding surface [nucleotide binding]; other site
701521003690	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
701521003691	active site
701521003692	uracil binding [chemical binding]; other site
701521003693	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
701521003694	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
701521003695	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
701521003696	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
701521003697	HIGH motif; other site
701521003698	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
701521003699	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
701521003700	active site
701521003701	KMSKS motif; other site
701521003702	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
701521003703	tRNA binding surface [nucleotide binding]; other site
701521003704	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
701521003705	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
701521003706	active site
701521003707	Methyltransferase domain; Region: Methyltransf_31; pfam13847
701521003708	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
701521003709	S-adenosylmethionine binding site [chemical binding]; other site
701521003710	Major Facilitator Superfamily; Region: MFS_1; pfam07690
701521003711	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
701521003712	putative substrate translocation pore; other site
701521003713	S-adenosylmethionine synthetase; Validated; Region: PRK05250
701521003714	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
701521003715	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
701521003716	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
701521003717	LysE type translocator; Region: LysE; cl00565
701521003718	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
701521003719	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
701521003720	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
701521003721	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
701521003722	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
701521003723	putative ADP-binding pocket [chemical binding]; other site
701521003724	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
701521003725	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
701521003726	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
701521003727	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
701521003728	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
701521003729	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
701521003730	dimerization domain swap beta strand [polypeptide binding]; other site
701521003731	regulatory protein interface [polypeptide binding]; other site
701521003732	active site
701521003733	regulatory phosphorylation site [posttranslational modification]; other site
701521003734	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
701521003735	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
701521003736	Walker A motif; other site
701521003737	ATP binding site [chemical binding]; other site
701521003738	Walker B motif; other site
701521003739	arginine finger; other site
701521003740	UvrB/uvrC motif; Region: UVR; pfam02151
701521003741	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
701521003742	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
701521003743	Walker A motif; other site
701521003744	ATP binding site [chemical binding]; other site
701521003745	Walker B motif; other site
701521003746	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
701521003747	Protein of unknown function (DUF1634); Region: DUF1634; pfam07843
701521003748	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
701521003749	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
701521003750	Sulfatase; Region: Sulfatase; pfam00884
701521003751	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
701521003752	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
701521003753	G1 box; other site
701521003754	putative GEF interaction site [polypeptide binding]; other site
701521003755	GTP/Mg2+ binding site [chemical binding]; other site
701521003756	Switch I region; other site
701521003757	G2 box; other site
701521003758	G3 box; other site
701521003759	Switch II region; other site
701521003760	G4 box; other site
701521003761	G5 box; other site
701521003762	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
701521003763	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
701521003764	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
701521003765	active site
701521003766	nucleotide binding site [chemical binding]; other site
701521003767	HIGH motif; other site
701521003768	KMSKS motif; other site
701521003769	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
701521003770	Domain of unknown function DUF20; Region: UPF0118; pfam01594
701521003771	hypothetical protein; Provisional; Region: PRK13662
701521003772	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
701521003773	Beta-lactamase; Region: Beta-lactamase; pfam00144
701521003774	RecX family; Region: RecX; cl00936
701521003775	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
701521003776	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
701521003777	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
701521003778	active site
701521003779	homodimer interface [polypeptide binding]; other site
701521003780	Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073
701521003781	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
701521003782	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
701521003783	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
701521003784	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
701521003785	ATP binding site [chemical binding]; other site
701521003786	putative Mg++ binding site [ion binding]; other site
701521003787	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
701521003788	nucleotide binding region [chemical binding]; other site
701521003789	ATP-binding site [chemical binding]; other site
701521003790	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
701521003791	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
701521003792	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
701521003793	active site
701521003794	amino acid transporter; Region: 2A0306; TIGR00909
701521003795	VanZ like family; Region: VanZ; cl01971
701521003796	VanZ like family; Region: VanZ; cl01971
701521003797	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
701521003798	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
701521003799	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
701521003800	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
701521003801	UDP-galactopyranose mutase; Region: GLF; pfam03275
701521003802	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
701521003803	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
701521003804	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
701521003805	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
701521003806	active site
701521003807	Bacterial sugar transferase; Region: Bac_transf; pfam02397
701521003808	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
701521003809	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
701521003810	active site
701521003811	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
701521003812	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
701521003813	Chain length determinant protein; Region: Wzz; cl15801
701521003814	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
701521003815	Beta-lactamase; Region: Beta-lactamase; pfam00144
701521003816	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
701521003817	Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269
701521003818	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
701521003819	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
701521003820	S-adenosylmethionine binding site [chemical binding]; other site
701521003821	putative lipid kinase; Reviewed; Region: PRK13055
701521003822	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
701521003823	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
701521003824	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
701521003825	GatB domain; Region: GatB_Yqey; smart00845
701521003826	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
701521003827	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
701521003828	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
701521003829	N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441
701521003830	putative dimer interface [polypeptide binding]; other site
701521003831	CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537
701521003832	C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440
701521003833	putative dimer interface [polypeptide binding]; other site
701521003834	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
701521003835	Part of AAA domain; Region: AAA_19; pfam13245
701521003836	Family description; Region: UvrD_C_2; pfam13538
701521003837	Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026
701521003838	ATP-grasp domain; Region: ATP-grasp_4; cl17255
701521003839	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
701521003840	active site
701521003841	Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705
701521003842	Predicted membrane protein [Function unknown]; Region: COG4684
701521003843	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
701521003844	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
701521003845	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
701521003846	NAD binding site [chemical binding]; other site
701521003847	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
701521003848	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
701521003849	23S rRNA interface [nucleotide binding]; other site
701521003850	L3 interface [polypeptide binding]; other site
701521003851	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
701521003852	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
701521003853	dimerization interface 3.5A [polypeptide binding]; other site
701521003854	active site
701521003855	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
701521003856	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13634
701521003857	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
701521003858	Walker A/P-loop; other site
701521003859	ATP binding site [chemical binding]; other site
701521003860	Q-loop/lid; other site
701521003861	ABC transporter signature motif; other site
701521003862	Walker B; other site
701521003863	D-loop; other site
701521003864	H-loop/switch region; other site
701521003865	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635
701521003866	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
701521003867	Walker A/P-loop; other site
701521003868	ATP binding site [chemical binding]; other site
701521003869	Q-loop/lid; other site
701521003870	ABC transporter signature motif; other site
701521003871	Walker B; other site
701521003872	D-loop; other site
701521003873	H-loop/switch region; other site
701521003874	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
701521003875	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
701521003876	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
701521003877	alphaNTD homodimer interface [polypeptide binding]; other site
701521003878	alphaNTD - beta interaction site [polypeptide binding]; other site
701521003879	alphaNTD - beta' interaction site [polypeptide binding]; other site
701521003880	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
701521003881	30S ribosomal protein S11; Validated; Region: PRK05309
701521003882	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
701521003883	30S ribosomal protein S13; Region: bact_S13; TIGR03631
701521003884	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
701521003885	rRNA binding site [nucleotide binding]; other site
701521003886	predicted 30S ribosome binding site; other site
701521003887	adenylate kinase; Reviewed; Region: adk; PRK00279
701521003888	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
701521003889	AMP-binding site [chemical binding]; other site
701521003890	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
701521003891	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
701521003892	SecY translocase; Region: SecY; pfam00344
701521003893	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
701521003894	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
701521003895	23S rRNA binding site [nucleotide binding]; other site
701521003896	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
701521003897	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
701521003898	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
701521003899	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
701521003900	5S rRNA interface [nucleotide binding]; other site
701521003901	L27 interface [polypeptide binding]; other site
701521003902	23S rRNA interface [nucleotide binding]; other site
701521003903	L5 interface [polypeptide binding]; other site
701521003904	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
701521003905	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
701521003906	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
701521003907	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
701521003908	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
701521003909	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
701521003910	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
701521003911	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
701521003912	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
701521003913	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
701521003914	RNA binding site [nucleotide binding]; other site
701521003915	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
701521003916	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
701521003917	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
701521003918	23S rRNA interface [nucleotide binding]; other site
701521003919	putative translocon interaction site; other site
701521003920	signal recognition particle (SRP54) interaction site; other site
701521003921	L23 interface [polypeptide binding]; other site
701521003922	trigger factor interaction site; other site
701521003923	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
701521003924	23S rRNA interface [nucleotide binding]; other site
701521003925	5S rRNA interface [nucleotide binding]; other site
701521003926	putative antibiotic binding site [chemical binding]; other site
701521003927	L25 interface [polypeptide binding]; other site
701521003928	L27 interface [polypeptide binding]; other site
701521003929	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
701521003930	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
701521003931	G-X-X-G motif; other site
701521003932	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
701521003933	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
701521003934	putative translocon binding site; other site
701521003935	protein-rRNA interface [nucleotide binding]; other site
701521003936	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
701521003937	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
701521003938	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
701521003939	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
701521003940	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
701521003941	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
701521003942	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
701521003943	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
701521003944	H+ Antiporter protein; Region: 2A0121; TIGR00900
701521003945	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
701521003946	putative substrate translocation pore; other site
701521003947	elongation factor G; Reviewed; Region: PRK12739
701521003948	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
701521003949	G1 box; other site
701521003950	putative GEF interaction site [polypeptide binding]; other site
701521003951	GTP/Mg2+ binding site [chemical binding]; other site
701521003952	Switch I region; other site
701521003953	G2 box; other site
701521003954	G3 box; other site
701521003955	Switch II region; other site
701521003956	G4 box; other site
701521003957	G5 box; other site
701521003958	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
701521003959	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
701521003960	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
701521003961	30S ribosomal protein S7; Validated; Region: PRK05302
701521003962	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
701521003963	S17 interaction site [polypeptide binding]; other site
701521003964	S8 interaction site; other site
701521003965	16S rRNA interaction site [nucleotide binding]; other site
701521003966	streptomycin interaction site [chemical binding]; other site
701521003967	23S rRNA interaction site [nucleotide binding]; other site
701521003968	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
701521003969	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
701521003970	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
701521003971	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
701521003972	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
701521003973	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
701521003974	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
701521003975	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
701521003976	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
701521003977	cleft; other site
701521003978	Rpb1 - Rpb5 interaction site [polypeptide binding]; other site
701521003979	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
701521003980	DNA binding site [nucleotide binding]
701521003981	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
701521003982	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
701521003983	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
701521003984	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
701521003985	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
701521003986	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
701521003987	RPB1 interaction site [polypeptide binding]; other site
701521003988	RPB10 interaction site [polypeptide binding]; other site
701521003989	RPB11 interaction site [polypeptide binding]; other site
701521003990	RPB3 interaction site [polypeptide binding]; other site
701521003991	RPB12 interaction site [polypeptide binding]; other site
701521003992	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
701521003993	Clp amino terminal domain; Region: Clp_N; pfam02861
701521003994	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
701521003995	Walker A motif; other site
701521003996	ATP binding site [chemical binding]; other site
701521003997	Walker B motif; other site
701521003998	arginine finger; other site
701521003999	UvrB/uvrC motif; Region: UVR; pfam02151
701521004000	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
701521004001	Walker A motif; other site
701521004002	ATP binding site [chemical binding]; other site
701521004003	Walker B motif; other site
701521004004	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
701521004005	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
701521004006	seryl-tRNA synthetase; Provisional; Region: PRK05431
701521004007	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
701521004008	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
701521004009	dimer interface [polypeptide binding]; other site
701521004010	active site
701521004011	motif 1; other site
701521004012	motif 2; other site
701521004013	motif 3; other site
701521004014	Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428
701521004015	Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673
701521004016	Substrate-binding site [chemical binding]; other site
701521004017	Substrate specificity [chemical binding]; other site
701521004018	lysine transporter; Provisional; Region: PRK10836
701521004019	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
701521004020	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
701521004021	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
701521004022	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
701521004023	Protein of unknown function (DUF3815); Region: DUF3815; pfam12821
701521004024	Uncharacterized conserved protein [Function unknown]; Region: COG2966
701521004025	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
701521004026	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
701521004027	DNA-binding site [nucleotide binding]; DNA binding site
701521004028	RNA-binding motif; other site
701521004029	Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321
701521004030	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
701521004031	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
701521004032	FeoA domain; Region: FeoA; pfam04023
701521004033	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
701521004034	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
701521004035	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
701521004036	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
701521004037	active site
701521004038	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
701521004039	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
701521004040	Zn2+ binding site [ion binding]; other site
701521004041	Mg2+ binding site [ion binding]; other site
701521004042	phosphodiesterase; Provisional; Region: PRK12704
701521004043	KH domain; Region: KH_1; pfam00013
701521004044	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
701521004045	Zn2+ binding site [ion binding]; other site
701521004046	Mg2+ binding site [ion binding]; other site
701521004047	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
701521004048	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
701521004049	Coenzyme A binding pocket [chemical binding]; other site
701521004050	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
701521004051	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
701521004052	active site
701521004053	glycoprotein BALF4; Provisional; Region: PHA03231
701521004054	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
701521004055	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
701521004056	ATP binding site [chemical binding]; other site
701521004057	putative Mg++ binding site [ion binding]; other site
701521004058	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
701521004059	nucleotide binding region [chemical binding]; other site
701521004060	ATP-binding site [chemical binding]; other site
701521004061	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
701521004062	HRDC domain; Region: HRDC; pfam00570
701521004063	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
701521004064	Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448
701521004065	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
701521004066	active site
701521004067	Bacterial SH3 domain; Region: SH3_5; pfam08460
701521004068	Bacterial SH3 domain; Region: SH3_5; pfam08460
701521004069	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
701521004070	H+ Antiporter protein; Region: 2A0121; TIGR00900
701521004071	putative substrate translocation pore; other site
701521004072	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
701521004073	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
701521004074	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
701521004075	active site
701521004076	Peptidase family C69; Region: Peptidase_C69; pfam03577
701521004077	CsbD-like; Region: CsbD; pfam05532
701521004078	branched-chain amino acid aminotransferase; Provisional; Region: PRK13357
701521004079	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
701521004080	homodimer interface [polypeptide binding]; other site
701521004081	substrate-cofactor binding pocket; other site
701521004082	catalytic residue [active]
701521004083	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
701521004084	Protein of unknown function (DUF3021); Region: DUF3021; pfam11457
701521004085	LytTr DNA-binding domain; Region: LytTR; smart00850
701521004086	GMP synthase; Reviewed; Region: guaA; PRK00074
701521004087	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
701521004088	AMP/PPi binding site [chemical binding]; other site
701521004089	candidate oxyanion hole; other site
701521004090	catalytic triad [active]
701521004091	potential glutamine specificity residues [chemical binding]; other site
701521004092	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
701521004093	ATP Binding subdomain [chemical binding]; other site
701521004094	Dimerization subdomain; other site
701521004095	pantothenate kinase; Provisional; Region: PRK05439
701521004096	Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025
701521004097	ATP-binding site [chemical binding]; other site
701521004098	CoA-binding site [chemical binding]; other site
701521004099	Mg2+-binding site [ion binding]; other site
701521004100	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
701521004101	acetolactate synthase; Reviewed; Region: PRK08617
701521004102	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
701521004103	PYR/PP interface [polypeptide binding]; other site
701521004104	dimer interface [polypeptide binding]; other site
701521004105	TPP binding site [chemical binding]; other site
701521004106	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
701521004107	Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010
701521004108	TPP-binding site [chemical binding]; other site
701521004109	dimer interface [polypeptide binding]; other site
701521004110	Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973
701521004111	Part of AAA domain; Region: AAA_19; pfam13245
701521004112	Family description; Region: UvrD_C_2; pfam13538
701521004113	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
701521004114	catalytic core [active]
701521004115	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
701521004116	inner membrane transporter YjeM; Provisional; Region: PRK15238
701521004117	NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242
701521004118	trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656
701521004119	Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241
701521004120	Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055
701521004121	glycerol kinase; Provisional; Region: glpK; PRK00047
701521004122	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
701521004123	N- and C-terminal domain interface [polypeptide binding]; other site
701521004124	active site
701521004125	MgATP binding site [chemical binding]; other site
701521004126	catalytic site [active]
701521004127	metal binding site [ion binding]; metal-binding site
701521004128	glycerol binding site [chemical binding]; other site
701521004129	homotetramer interface [polypeptide binding]; other site
701521004130	homodimer interface [polypeptide binding]; other site
701521004131	FBP binding site [chemical binding]; other site
701521004132	protein IIAGlc interface [polypeptide binding]; other site
701521004133	Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350
701521004134	Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348
701521004135	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
701521004136	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
701521004137	phosphate binding site [ion binding]; other site
701521004138	1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046
701521004139	putative hexamer interface [polypeptide binding]; other site
701521004140	putative hexagonal pore; other site
701521004141	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
701521004142	propionate/acetate kinase; Provisional; Region: PRK12379
701521004143	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
701521004144	1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180
701521004145	putative active site [active]
701521004146	metal binding site [ion binding]; metal-binding site
701521004147	Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121
701521004148	putative catalytic cysteine [active]
701521004149	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
701521004150	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
701521004151	Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614
701521004152	Hexamer/Pentamer interface [polypeptide binding]; other site
701521004153	central pore; other site
701521004154	putative propanediol utilization protein PduM; Provisional; Region: PRK15428
701521004155	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
701521004156	Propanediol utilisation protein PduL; Region: PduL; pfam06130
701521004157	Propanediol utilisation protein PduL; Region: PduL; pfam06130
701521004158	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
701521004159	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
701521004160	Hexamer interface [polypeptide binding]; other site
701521004161	Hexagonal pore residue; other site
701521004162	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
701521004163	Bacterial Micro-Compartment (BMC) domain; Region: BMC; cl01982
701521004164	Hexamer interface [polypeptide binding]; other site
701521004165	Hexagonal pore residue; other site
701521004166	Dehydratase medium subunit; Region: Dehydratase_MU; pfam02288
701521004167	Cell division protein FtsA; Region: FtsA; cl17206
701521004168	Diol dehydratase reactivase ATPase-like domain; Region: DDR; pfam08841
701521004169	Dehydratase small subunit; Region: Dehydratase_SU; pfam02287
701521004170	propanediol dehydratase medium subunit; Provisional; Region: pduD; PRK15042
701521004171	Propanediol dehydratase, large subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PduC; COG4909
701521004172	Dehydratase large subunit. This family contains the large (alpha) subunit of B12-dependent glycerol dehydratases (GDHs) and B12-dependent diol dehydratases (DDHs). GDH is isofunctional with DDH. These enzymes can each catalyze the conversion of 1; Region: Dehydratase_LU; cd03687
701521004173	alpha-alpha subunit/dimer interface [polypeptide binding]; other site
701521004174	alpha-beta subunit interface [polypeptide binding]; other site
701521004175	alpha-gamma subunit interface [polypeptide binding]; other site
701521004176	active site
701521004177	substrate and K+ binding site; other site
701521004178	K+ binding site [ion binding]; other site
701521004179	cobalamin binding site [chemical binding]; other site
701521004180	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047
701521004181	Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutL; COG4816
701521004182	putative hexamer interface [polypeptide binding]; other site
701521004183	putative hexagonal pore; other site
701521004184	1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048
701521004185	putative hexamer interface [polypeptide binding]; other site
701521004186	putative hexagonal pore; other site
701521004187	Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577
701521004188	Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045
701521004189	Hexamer interface [polypeptide binding]; other site
701521004190	Hexagonal pore residue; other site
701521004191	Elongation factor Tu GTP binding domain; Region: GTP_EFTU; pfam00009
701521004192	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
701521004193	G1 box; other site
701521004194	GTP/Mg2+ binding site [chemical binding]; other site
701521004195	G2 box; other site
701521004196	Switch I region; other site
701521004197	G3 box; other site
701521004198	Switch II region; other site
701521004199	G4 box; other site
701521004200	G5 box; other site
701521004201	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
701521004202	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
701521004203	active site pocket [active]
701521004204	putative dimer interface [polypeptide binding]; other site
701521004205	putative cataytic base [active]
701521004206	Domain of unknown function (DUF4135); Region: DUF4135; pfam13575
701521004207	Cobalamin biosynthesis protein CbiK, Co2+ chelatase [Coenzyme metabolism]; Region: CbiK; COG4822
701521004208	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
701521004209	active site
701521004210	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
701521004211	active site
701521004212	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
701521004213	active site
701521004214	SAM binding site [chemical binding]; other site
701521004215	homodimer interface [polypeptide binding]; other site
701521004216	Cobalt chelatase (CbiK); Region: CbiK; pfam06180
701521004217	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
701521004218	active site
701521004219	Anaerobic cobalamin biosynthetic cobalt chelatase (CbiK), C-terminal domain. CbiK is part of the cobalt-early path for cobalamin biosynthesis. It catalyzes the insertion of cobalt into the oxidized form of precorrin-2, factor II (sirohydrochlorin), the...; Region: CbiK_C; cd03413
701521004220	active site
701521004221	N-terminal domain interface [polypeptide binding]; other site
701521004222	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
701521004223	active site
701521004224	SAM binding site [chemical binding]; other site
701521004225	homodimer interface [polypeptide binding]; other site
701521004226	Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099
701521004227	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
701521004228	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
701521004229	active site
701521004230	SAM binding site [chemical binding]; other site
701521004231	homodimer interface [polypeptide binding]; other site
701521004232	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
701521004233	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
701521004234	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
701521004235	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
701521004236	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
701521004237	active site
701521004238	SAM binding site [chemical binding]; other site
701521004239	homodimer interface [polypeptide binding]; other site
701521004240	cobalt-precorrin-6Y C(15)-methyltransferase; Validated; Region: PRK08287
701521004241	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
701521004242	S-adenosylmethionine binding site [chemical binding]; other site
701521004243	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
701521004244	active site
701521004245	putative homodimer interface [polypeptide binding]; other site
701521004246	SAM binding site [chemical binding]; other site
701521004247	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
701521004248	Precorrin-8X methylmutase; Region: CbiC; pfam02570
701521004249	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
701521004250	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
701521004251	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
701521004252	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
701521004253	catalytic triad [active]
701521004254	threonine-phosphate decarboxylase; Provisional; Region: PRK06358
701521004255	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
701521004256	pyridoxal 5'-phosphate binding site [chemical binding]; other site
701521004257	homodimer interface [polypeptide binding]; other site
701521004258	catalytic residue [active]
701521004259	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
701521004260	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
701521004261	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
701521004262	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
701521004263	active site
701521004264	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
701521004265	catalytic core [active]
701521004266	cobalamin synthase; Reviewed; Region: cobS; PRK00235
701521004267	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
701521004268	homotrimer interface [polypeptide binding]; other site
701521004269	Walker A motif; other site
701521004270	GTP binding site [chemical binding]; other site
701521004271	Walker B motif; other site
701521004272	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
701521004273	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
701521004274	inhibitor-cofactor binding pocket; inhibition site
701521004275	pyridoxal 5'-phosphate binding site [chemical binding]; other site
701521004276	catalytic residue [active]
701521004277	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
701521004278	dimer interface [polypeptide binding]; other site
701521004279	active site
701521004280	Schiff base residues; other site
701521004281	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
701521004282	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
701521004283	domain interfaces; other site
701521004284	active site
701521004285	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
701521004286	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
701521004287	tRNA; other site
701521004288	putative tRNA binding site [nucleotide binding]; other site
701521004289	putative NADP binding site [chemical binding]; other site
701521004290	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
701521004291	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
701521004292	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
701521004293	cobyric acid synthase; Provisional; Region: PRK00784
701521004294	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
701521004295	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
701521004296	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
701521004297	catalytic triad [active]
701521004298	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
701521004299	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
701521004300	Walker A/P-loop; other site
701521004301	ATP binding site [chemical binding]; other site
701521004302	Q-loop/lid; other site
701521004303	ABC transporter signature motif; other site
701521004304	Walker B; other site
701521004305	D-loop; other site
701521004306	H-loop/switch region; other site
701521004307	Cobalt transport protein; Region: CbiQ; cl00463
701521004308	cobalt transport protein CbiN; Provisional; Region: PRK02898
701521004309	cobalt transport protein CbiM; Validated; Region: PRK08319
701521004310	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
701521004311	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
701521004312	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
701521004313	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
701521004314	High-affinity nickel-transport protein; Region: NicO; cl00964
701521004315	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
701521004316	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
701521004317	Walker A/P-loop; other site
701521004318	ATP binding site [chemical binding]; other site
701521004319	Q-loop/lid; other site
701521004320	ABC transporter signature motif; other site
701521004321	Walker B; other site
701521004322	D-loop; other site
701521004323	H-loop/switch region; other site
701521004324	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
701521004325	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
701521004326	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
701521004327	Walker A/P-loop; other site
701521004328	ATP binding site [chemical binding]; other site
701521004329	Q-loop/lid; other site
701521004330	ABC transporter signature motif; other site
701521004331	Walker B; other site
701521004332	D-loop; other site
701521004333	H-loop/switch region; other site
701521004334	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
701521004335	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
701521004336	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
701521004337	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
701521004338	dimer interface [polypeptide binding]; other site
701521004339	conserved gate region; other site
701521004340	putative PBP binding loops; other site
701521004341	ABC-ATPase subunit interface; other site
701521004342	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
701521004343	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
701521004344	dimer interface [polypeptide binding]; other site
701521004345	conserved gate region; other site
701521004346	putative PBP binding loops; other site
701521004347	ABC-ATPase subunit interface; other site
701521004348	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
701521004349	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
701521004350	peptide binding site [polypeptide binding]; other site
701521004351	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
701521004352	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
701521004353	HflX GTPase family; Region: HflX; cd01878
701521004354	G1 box; other site
701521004355	GTP/Mg2+ binding site [chemical binding]; other site
701521004356	Switch I region; other site
701521004357	G2 box; other site
701521004358	G3 box; other site
701521004359	Switch II region; other site
701521004360	G4 box; other site
701521004361	G5 box; other site
701521004362	Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097
701521004363	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
701521004364	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322
701521004365	FAD binding pocket [chemical binding]; other site
701521004366	conserved FAD binding motif [chemical binding]; other site
701521004367	phosphate binding motif [ion binding]; other site
701521004368	beta-alpha-beta structure motif; other site
701521004369	NAD binding pocket [chemical binding]; other site
701521004370	ApbE family; Region: ApbE; pfam02424
701521004371	FMN-binding domain; Region: FMN_bind; cl01081
701521004372	short chain dehydrogenase; Provisional; Region: PRK06123
701521004373	Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324
701521004374	NADP binding site [chemical binding]; other site
701521004375	substrate binding site [chemical binding]; other site
701521004376	active site
701521004377	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
701521004378	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
701521004379	DNA binding residues [nucleotide binding]
701521004380	putative dimer interface [polypeptide binding]; other site
701521004381	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
701521004382	MgtC family; Region: MgtC; pfam02308
701521004383	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
701521004384	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
701521004385	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
701521004386	beta-galactosidase; Region: BGL; TIGR03356
701521004387	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
701521004388	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
701521004389	DNA-binding site [nucleotide binding]; DNA binding site
701521004390	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
701521004391	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
701521004392	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
701521004393	active site
701521004394	phosphorylation site [posttranslational modification]
701521004395	intermolecular recognition site; other site
701521004396	LytTr DNA-binding domain; Region: LytTR; pfam04397
701521004397	Bacterial SH3 domain; Region: SH3_5; pfam08460
701521004398	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
701521004399	NlpC/P60 family; Region: NLPC_P60; pfam00877
701521004400	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
701521004401	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
701521004402	putative substrate translocation pore; other site
701521004403	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
701521004404	D-ribose pyranase; Provisional; Region: PRK11797
701521004405	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
701521004406	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
701521004407	substrate binding site [chemical binding]; other site
701521004408	dimer interface [polypeptide binding]; other site
701521004409	ATP binding site [chemical binding]; other site
701521004410	Transcriptional regulators [Transcription]; Region: PurR; COG1609
701521004411	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
701521004412	DNA binding site [nucleotide binding]
701521004413	domain linker motif; other site
701521004414	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
701521004415	dimerization interface [polypeptide binding]; other site
701521004416	ligand binding site [chemical binding]; other site
701521004417	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
701521004418	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
701521004419	dimer interface [polypeptide binding]; other site
701521004420	conserved gate region; other site
701521004421	putative PBP binding loops; other site
701521004422	ABC-ATPase subunit interface; other site
701521004423	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
701521004424	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
701521004425	dimer interface [polypeptide binding]; other site
701521004426	conserved gate region; other site
701521004427	putative PBP binding loops; other site
701521004428	ABC-ATPase subunit interface; other site
701521004429	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
701521004430	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
701521004431	substrate binding pocket [chemical binding]; other site
701521004432	membrane-bound complex binding site; other site
701521004433	hinge residues; other site
701521004434	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
701521004435	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
701521004436	Walker A/P-loop; other site
701521004437	ATP binding site [chemical binding]; other site
701521004438	Q-loop/lid; other site
701521004439	ABC transporter signature motif; other site
701521004440	Walker B; other site
701521004441	D-loop; other site
701521004442	H-loop/switch region; other site
701521004443	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
701521004444	metal binding site 2 [ion binding]; metal-binding site
701521004445	putative DNA binding helix; other site
701521004446	metal binding site 1 [ion binding]; metal-binding site
701521004447	dimer interface [polypeptide binding]; other site
701521004448	structural Zn2+ binding site [ion binding]; other site
701521004449	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
701521004450	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
701521004451	active site
701521004452	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
701521004453	nudix motif; other site
701521004454	amino acid transporter; Region: 2A0306; TIGR00909
701521004455	Cobalamin-5-phosphate synthase; Region: CobS; cl00415
701521004456	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
701521004457	x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371
701521004458	X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; pfam09168
701521004459	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530
701521004460	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
701521004461	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
701521004462	proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250
701521004463	TAP-like protein; Region: Abhydrolase_4; pfam08386
701521004464	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
701521004465	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
701521004466	active site
701521004467	catalytic tetrad [active]
701521004468	Old yellow enzyme (OYE)-related FMN binding domain, group 4.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735
701521004469	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
701521004470	putative active site [active]
701521004471	putative FMN binding site [chemical binding]; other site
701521004472	putative substrate binding site [chemical binding]; other site
701521004473	putative catalytic residue [active]
701521004474	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
701521004475	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
701521004476	Walker A/P-loop; other site
701521004477	ATP binding site [chemical binding]; other site
701521004478	Q-loop/lid; other site
701521004479	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
701521004480	ABC transporter signature motif; other site
701521004481	Walker B; other site
701521004482	D-loop; other site
701521004483	ABC transporter; Region: ABC_tran_2; pfam12848
701521004484	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
701521004485	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
701521004486	dimer interface [polypeptide binding]; other site
701521004487	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
701521004488	metal binding site [ion binding]; metal-binding site
701521004489	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
701521004490	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
701521004491	Catalytic site [active]
701521004492	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
701521004493	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
701521004494	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
701521004495	putative catalytic cysteine [active]
701521004496	gamma-glutamyl kinase; Provisional; Region: PRK05429
701521004497	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
701521004498	nucleotide binding site [chemical binding]; other site
701521004499	homotetrameric interface [polypeptide binding]; other site
701521004500	putative phosphate binding site [ion binding]; other site
701521004501	putative allosteric binding site; other site
701521004502	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
701521004503	active site
701521004504	EDD domain protein, DegV family; Region: DegV; TIGR00762
701521004505	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
701521004506	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
701521004507	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
701521004508	catalytic residues [active]
701521004509	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
701521004510	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
701521004511	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
701521004512	Cl binding site [ion binding]; other site
701521004513	oligomer interface [polypeptide binding]; other site
701521004514	YibE/F-like protein; Region: YibE_F; pfam07907
701521004515	YibE/F-like protein; Region: YibE_F; pfam07907
701521004516	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
701521004517	Coenzyme A binding pocket [chemical binding]; other site
701521004518	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
701521004519	Sulfatase; Region: Sulfatase; pfam00884
701521004520	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
701521004521	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
701521004522	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
701521004523	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
701521004524	active site
701521004525	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
701521004526	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
701521004527	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
701521004528	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
701521004529	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
701521004530	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
701521004531	non-specific DNA binding site [nucleotide binding]; other site
701521004532	salt bridge; other site
701521004533	sequence-specific DNA binding site [nucleotide binding]; other site
701521004534	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
701521004535	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
701521004536	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
701521004537	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
701521004538	benzoate transport; Region: 2A0115; TIGR00895
701521004539	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
701521004540	putative substrate translocation pore; other site
701521004541	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
701521004542	Ligand Binding Site [chemical binding]; other site
701521004543	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
701521004544	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
701521004545	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
701521004546	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
701521004547	Walker A/P-loop; other site
701521004548	ATP binding site [chemical binding]; other site
701521004549	Q-loop/lid; other site
701521004550	ABC transporter signature motif; other site
701521004551	Walker B; other site
701521004552	D-loop; other site
701521004553	H-loop/switch region; other site
701521004554	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
701521004555	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
701521004556	active site
701521004557	putative phosphoketolase; Provisional; Region: PRK05261
701521004558	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
701521004559	TPP-binding site; other site
701521004560	XFP C-terminal domain; Region: XFP_C; pfam09363
701521004561	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
701521004562	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
701521004563	DNA-binding site [nucleotide binding]; DNA binding site
701521004564	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
701521004565	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
701521004566	putative deacylase active site [active]
701521004567	Protein of unknown function (DUF1003); Region: DUF1003; pfam06210
701521004568	Domain of unknown function (DUF1836); Region: DUF1836; pfam08876
701521004569	EamA-like transporter family; Region: EamA; pfam00892
701521004570	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
701521004571	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
701521004572	active site
701521004573	catalytic residues [active]
701521004574	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
701521004575	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
701521004576	active site
701521004577	motif I; other site
701521004578	motif II; other site
701521004579	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
701521004580	Membrane transport protein; Region: Mem_trans; cl09117
701521004581	malate dehydrogenase; Provisional; Region: PRK13529
701521004582	Malic enzyme, N-terminal domain; Region: malic; pfam00390
701521004583	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
701521004584	NAD(P) binding site [chemical binding]; other site
701521004585	Transcriptional regulator [Transcription]; Region: LysR; COG0583
701521004586	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
701521004587	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
701521004588	dimerization interface [polypeptide binding]; other site
701521004589	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
701521004590	active site
701521004591	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
701521004592	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
701521004593	motif II; other site
701521004594	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
701521004595	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
701521004596	Cl- selectivity filter; other site
701521004597	Cl- binding residues [ion binding]; other site
701521004598	pore gating glutamate residue; other site
701521004599	dimer interface [polypeptide binding]; other site
701521004600	H+/Cl- coupling transport residue; other site
701521004601	TrkA-C domain; Region: TrkA_C; pfam02080
701521004602	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
701521004603	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
701521004604	active site
701521004605	metal binding site [ion binding]; metal-binding site
701521004606	oligoendopeptidase F; Region: pepF; TIGR00181
701521004607	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608
701521004608	active site
701521004609	Zn binding site [ion binding]; other site
701521004610	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
701521004611	enolase; Provisional; Region: eno; PRK00077
701521004612	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
701521004613	dimer interface [polypeptide binding]; other site
701521004614	metal binding site [ion binding]; metal-binding site
701521004615	substrate binding pocket [chemical binding]; other site
701521004616	Uncharacterized membrane-anchored protein conserved in bacteria [Function unknown]; Region: COG4705
701521004617	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
701521004618	cyanate transporter; Region: CynX; TIGR00896
701521004619	putative substrate translocation pore; other site
701521004620	Uncharacterized conserved protein [Function unknown]; Region: COG1284
701521004621	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
701521004622	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
701521004623	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
701521004624	beta-galactosidase; Region: BGL; TIGR03356
701521004625	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
701521004626	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
701521004627	nucleotide binding site [chemical binding]; other site
701521004628	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
701521004629	substrate binding site [chemical binding]; other site
701521004630	THF binding site; other site
701521004631	zinc-binding site [ion binding]; other site
701521004632	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
701521004633	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
701521004634	dimer interface [polypeptide binding]; other site
701521004635	conserved gate region; other site
701521004636	putative PBP binding loops; other site
701521004637	ABC-ATPase subunit interface; other site
701521004638	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
701521004639	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
701521004640	Walker A/P-loop; other site
701521004641	ATP binding site [chemical binding]; other site
701521004642	Q-loop/lid; other site
701521004643	ABC transporter signature motif; other site
701521004644	Walker B; other site
701521004645	D-loop; other site
701521004646	H-loop/switch region; other site
701521004647	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
701521004648	probable dihydroxyacetone kinase regulator; Region: DHAK_reg; TIGR02366
701521004649	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
701521004650	Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278
701521004651	Amidohydrolase; Region: Amidohydro_2; pfam04909
701521004652	S-ribosylhomocysteinase; Provisional; Region: PRK02260
701521004653	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
701521004654	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
701521004655	pyridoxal 5'-phosphate binding site [chemical binding]; other site
701521004656	homodimer interface [polypeptide binding]; other site
701521004657	catalytic residue [active]
701521004658	Isochorismatase family; Region: Isochorismatase; pfam00857
701521004659	Nicotinamidase_ related amidohydrolases.  Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014
701521004660	catalytic triad [active]
701521004661	conserved cis-peptide bond; other site
701521004662	EDD domain protein, DegV family; Region: DegV; TIGR00762
701521004663	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
701521004664	PemK-like protein; Region: PemK; pfam02452
701521004665	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
701521004666	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
701521004667	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
701521004668	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
701521004669	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
701521004670	Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527
701521004671	Sterol carrier protein domain; Region: SCP2_2; pfam13530
701521004672	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
701521004673	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
701521004674	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
701521004675	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
701521004676	Walker A motif; other site
701521004677	ATP binding site [chemical binding]; other site
701521004678	Walker B motif; other site
701521004679	arginine finger; other site
701521004680	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
701521004681	Walker A motif; other site
701521004682	ATP binding site [chemical binding]; other site
701521004683	Walker B motif; other site
701521004684	arginine finger; other site
701521004685	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
701521004686	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
701521004687	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
701521004688	active site
701521004689	multimer interface [polypeptide binding]; other site
701521004690	MarR family; Region: MarR_2; pfam12802
701521004691	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
701521004692	active site
701521004693	catalytic residues [active]
701521004694	metal binding site [ion binding]; metal-binding site
701521004695	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
701521004696	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
701521004697	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
701521004698	active site
701521004699	motif I; other site
701521004700	motif II; other site
701521004701	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
701521004702	Putative transcription activator [Transcription]; Region: TenA; COG0819
701521004703	Cobalt transport protein; Region: CbiQ; cl00463
701521004704	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
701521004705	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
701521004706	Walker A/P-loop; other site
701521004707	ATP binding site [chemical binding]; other site
701521004708	Q-loop/lid; other site
701521004709	ABC transporter signature motif; other site
701521004710	Walker B; other site
701521004711	D-loop; other site
701521004712	H-loop/switch region; other site
701521004713	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
701521004714	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
701521004715	Walker A/P-loop; other site
701521004716	ATP binding site [chemical binding]; other site
701521004717	Q-loop/lid; other site
701521004718	ABC transporter signature motif; other site
701521004719	Walker B; other site
701521004720	D-loop; other site
701521004721	H-loop/switch region; other site
701521004722	ABC-type cobalt transport system, permease component; Region: ABC_cobalt; pfam09819
701521004723	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
701521004724	thiamine phosphate binding site [chemical binding]; other site
701521004725	active site
701521004726	pyrophosphate binding site [ion binding]; other site
701521004727	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
701521004728	dimer interface [polypeptide binding]; other site
701521004729	substrate binding site [chemical binding]; other site
701521004730	ATP binding site [chemical binding]; other site
701521004731	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
701521004732	substrate binding site [chemical binding]; other site
701521004733	multimerization interface [polypeptide binding]; other site
701521004734	ATP binding site [chemical binding]; other site
701521004735	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
701521004736	Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972
701521004737	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
701521004738	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
701521004739	myosin-cross-reactive antigen; Provisional; Region: PRK13977
701521004740	CAAX protease self-immunity; Region: Abi; pfam02517
701521004741	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
701521004742	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
701521004743	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
701521004744	DNA binding residues [nucleotide binding]
701521004745	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876
701521004746	Predicted membrane protein [Function unknown]; Region: COG2261
701521004747	Asp23 family; Region: Asp23; pfam03780
701521004748	Asp23 family; Region: Asp23; pfam03780
701521004749	Protein of unknown function (DUF1211); Region: DUF1211; cl01421
701521004750	NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841
701521004751	active site
701521004752	catalytic triad [active]
701521004753	oxyanion hole [active]
701521004754	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
701521004755	MarR family; Region: MarR_2; pfam12802
701521004756	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
701521004757	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
701521004758	Soluble P-type ATPase [General function prediction only]; Region: COG4087
701521004759	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
701521004760	Penicillinase repressor; Region: Pencillinase_R; pfam03965
701521004761	Transcriptional regulator [Transcription]; Region: LysR; COG0583
701521004762	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
701521004763	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
701521004764	dimerization interface [polypeptide binding]; other site
701521004765	aspartate aminotransferase; Provisional; Region: PRK05764
701521004766	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
701521004767	pyridoxal 5'-phosphate binding site [chemical binding]; other site
701521004768	homodimer interface [polypeptide binding]; other site
701521004769	catalytic residue [active]
701521004770	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
701521004771	active site
701521004772	GyrI-like small molecule binding domain; Region: GyrI-like; cl01368
701521004773	L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291
701521004774	tetramer (dimer of dimers) interface [polypeptide binding]; other site
701521004775	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
701521004776	NAD binding site [chemical binding]; other site
701521004777	dimer interface [polypeptide binding]; other site
701521004778	substrate binding site [chemical binding]; other site
701521004779	Predicted membrane protein [Function unknown]; Region: COG2855
701521004780	Transcriptional regulator [Transcription]; Region: LysR; COG0583
701521004781	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
701521004782	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
701521004783	dimerization interface [polypeptide binding]; other site
701521004784	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
701521004785	NADH(P)-binding; Region: NAD_binding_10; pfam13460
701521004786	NAD(P) binding site [chemical binding]; other site
701521004787	active site
701521004788	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
701521004789	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
701521004790	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
701521004791	Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085
701521004792	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807
701521004793	pyruvate oxidase; Provisional; Region: PRK08611
701521004794	Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039
701521004795	PYR/PP interface [polypeptide binding]; other site
701521004796	dimer interface [polypeptide binding]; other site
701521004797	tetramer interface [polypeptide binding]; other site
701521004798	TPP binding site [chemical binding]; other site
701521004799	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
701521004800	Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014
701521004801	TPP-binding site [chemical binding]; other site
701521004802	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
701521004803	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
701521004804	Walker A/P-loop; other site
701521004805	ATP binding site [chemical binding]; other site
701521004806	Q-loop/lid; other site
701521004807	ABC transporter signature motif; other site
701521004808	Walker B; other site
701521004809	D-loop; other site
701521004810	H-loop/switch region; other site
701521004811	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
701521004812	FtsX-like permease family; Region: FtsX; pfam02687
701521004813	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
701521004814	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
701521004815	active site
701521004816	phosphorylation site [posttranslational modification]
701521004817	intermolecular recognition site; other site
701521004818	dimerization interface [polypeptide binding]; other site
701521004819	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
701521004820	DNA binding site [nucleotide binding]
701521004821	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
701521004822	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
701521004823	dimer interface [polypeptide binding]; other site
701521004824	phosphorylation site [posttranslational modification]
701521004825	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
701521004826	ATP binding site [chemical binding]; other site
701521004827	Mg2+ binding site [ion binding]; other site
701521004828	G-X-G motif; other site
701521004829	Predicted membrane protein [Function unknown]; Region: COG4709
701521004830	Predicted transcriptional regulators [Transcription]; Region: COG1695
701521004831	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
701521004832	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
701521004833	N-glycosyltransferase; Provisional; Region: PRK11204
701521004834	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
701521004835	DXD motif; other site
701521004836	Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948
701521004837	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
701521004838	active site
701521004839	Cytidine and deoxycytidylate deaminase zinc-binding region. The family contains cytidine deaminases, nucleoside deaminases, deoxycytidylate deaminases and riboflavin deaminases. Also included are the apoBec family of mRNA editing enzymes.  All members...; Region: cytidine_deaminase-like; cl00269
701521004840	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
701521004841	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
701521004842	putative acyltransferase; Provisional; Region: PRK05790
701521004843	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
701521004844	dimer interface [polypeptide binding]; other site
701521004845	active site
701521004846	Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268
701521004847	active site
701521004848	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
701521004849	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
701521004850	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
701521004851	Transcriptional regulator [Transcription]; Region: LysR; COG0583
701521004852	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
701521004853	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
701521004854	dimerization interface [polypeptide binding]; other site
701521004855	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
701521004856	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
701521004857	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
701521004858	ligand binding site [chemical binding]; other site
701521004859	flexible hinge region; other site
701521004860	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
701521004861	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
701521004862	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
701521004863	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
701521004864	S-adenosylmethionine binding site [chemical binding]; other site
701521004865	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
701521004866	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
701521004867	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
701521004868	Major Facilitator Superfamily; Region: MFS_1; pfam07690
701521004869	putative substrate translocation pore; other site
701521004870	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
701521004871	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
701521004872	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
701521004873	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
701521004874	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
701521004875	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
701521004876	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
701521004877	NAD(P) binding site [chemical binding]; other site
701521004878	active site
701521004879	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
701521004880	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
701521004881	potential catalytic triad [active]
701521004882	conserved cys residue [active]
701521004883	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
701521004884	dimerization interface [polypeptide binding]; other site
701521004885	putative DNA binding site [nucleotide binding]; other site
701521004886	putative Zn2+ binding site [ion binding]; other site
701521004887	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
701521004888	non-specific DNA binding site [nucleotide binding]; other site
701521004889	salt bridge; other site
701521004890	sequence-specific DNA binding site [nucleotide binding]; other site
701521004891	H+ Antiporter protein; Region: 2A0121; TIGR00900
701521004892	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
701521004893	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
701521004894	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
701521004895	Walker A/P-loop; other site
701521004896	ATP binding site [chemical binding]; other site
701521004897	Q-loop/lid; other site
701521004898	ABC transporter signature motif; other site
701521004899	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
701521004900	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
701521004901	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
701521004902	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
701521004903	hypothetical protein; Provisional; Region: PRK13690
701521004904	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
701521004905	substrate binding site [chemical binding]; other site
701521004906	ATP binding site [chemical binding]; other site
701521004907	Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073
701521004908	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
701521004909	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
701521004910	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
701521004911	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
701521004912	catalytic core [active]
701521004913	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
701521004914	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
701521004915	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
701521004916	S-adenosylmethionine binding site [chemical binding]; other site
701521004917	oxidoreductase; Provisional; Region: PRK06196
701521004918	retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs; Region: retinol-DH_like_SDR_c_like; cd05327
701521004919	putative NAD(P) binding site [chemical binding]; other site
701521004920	active site
701521004921	short chain dehydrogenase; Provisional; Region: PRK06914
701521004922	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
701521004923	NADP binding site [chemical binding]; other site
701521004924	active site
701521004925	steroid binding site; other site
701521004926	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
701521004927	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
701521004928	DNA binding residues [nucleotide binding]
701521004929	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
701521004930	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
701521004931	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
701521004932	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
701521004933	AzlC protein; Region: AzlC; pfam03591
701521004934	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
701521004935	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
701521004936	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
701521004937	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
701521004938	dimer interface [polypeptide binding]; other site
701521004939	phosphorylation site [posttranslational modification]
701521004940	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
701521004941	ATP binding site [chemical binding]; other site
701521004942	Mg2+ binding site [ion binding]; other site
701521004943	G-X-G motif; other site
701521004944	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
701521004945	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
701521004946	active site
701521004947	phosphorylation site [posttranslational modification]
701521004948	intermolecular recognition site; other site
701521004949	dimerization interface [polypeptide binding]; other site
701521004950	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
701521004951	DNA binding site [nucleotide binding]
701521004952	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
701521004953	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
701521004954	DNA binding site [nucleotide binding]
701521004955	active site
701521004956	inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843
701521004957	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
701521004958	active site
701521004959	Protein of unknown function (DUF1129); Region: DUF1129; pfam06570
701521004960	GTP-binding protein YchF; Reviewed; Region: PRK09601
701521004961	YchF GTPase; Region: YchF; cd01900
701521004962	G1 box; other site
701521004963	GTP/Mg2+ binding site [chemical binding]; other site
701521004964	Switch I region; other site
701521004965	G2 box; other site
701521004966	Switch II region; other site
701521004967	G3 box; other site
701521004968	G4 box; other site
701521004969	G5 box; other site
701521004970	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
701521004971	CAAX protease self-immunity; Region: Abi; pfam02517
701521004972	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
701521004973	ParB-like nuclease domain; Region: ParB; smart00470
701521004974	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
701521004975	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
701521004976	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
701521004977	S-adenosylmethionine binding site [chemical binding]; other site
701521004978	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270
701521004979	Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087
701521004980	Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744
701521004981	galactokinase; Provisional; Region: PRK05322
701521004982	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
701521004983	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
701521004984	Putative esterase; Region: Esterase; pfam00756
701521004985	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
701521004986	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
701521004987	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
701521004988	Melibiase; Region: Melibiase; pfam02065
701521004989	DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339
701521004990	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
701521004991	DNA binding site [nucleotide binding]
701521004992	domain linker motif; other site
701521004993	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
701521004994	GIY-YIG domain of uncharacterized bacterial protein structurally related to COG3410; Region: GIY-YIG_COG3410; cd10439
701521004995	GIY-YIG motif/motif A; other site
701521004996	putative active site [active]
701521004997	putative metal binding site [ion binding]; other site
701521004998	Uncharacterized conserved protein (DUF2075); Region: DUF2075; pfam09848
701521004999	Uncharacterized conserved protein [Function unknown]; Region: COG3410
701521005000	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
701521005001	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
701521005002	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
701521005003	putative active site [active]
701521005004	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
701521005005	PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995
701521005006	active site turn [active]
701521005007	phosphorylation site [posttranslational modification]
701521005008	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
701521005009	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
701521005010	HPr interaction site; other site
701521005011	glycerol kinase (GK) interaction site [polypeptide binding]; other site
701521005012	active site
701521005013	phosphorylation site [posttranslational modification]
701521005014	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
701521005015	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
701521005016	putative active site [active]
701521005017	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
701521005018	NADH(P)-binding; Region: NAD_binding_10; pfam13460
701521005019	NAD(P) binding site [chemical binding]; other site
701521005020	putative active site [active]
701521005021	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
701521005022	Helix-Turn-Helix DNA binding domain of the BmrR transcription regulator; Region: HTH_BmrR; cd01107
701521005023	DNA binding residues [nucleotide binding]
701521005024	drug binding residues [chemical binding]; other site
701521005025	dimer interface [polypeptide binding]; other site
701521005026	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
701521005027	HPr interaction site; other site
701521005028	glycerol kinase (GK) interaction site [polypeptide binding]; other site
701521005029	active site
701521005030	phosphorylation site [posttranslational modification]
701521005031	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
701521005032	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
701521005033	active site turn [active]
701521005034	phosphorylation site [posttranslational modification]
701521005035	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
701521005036	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
701521005037	HPr interaction site; other site
701521005038	glycerol kinase (GK) interaction site [polypeptide binding]; other site
701521005039	active site
701521005040	phosphorylation site [posttranslational modification]
701521005041	PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996
701521005042	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
701521005043	active site turn [active]
701521005044	phosphorylation site [posttranslational modification]
701521005045	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
701521005046	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
701521005047	DNA-binding site [nucleotide binding]; DNA binding site
701521005048	trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404
701521005049	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
701521005050	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
701521005051	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
701521005052	Ca binding site [ion binding]; other site
701521005053	active site
701521005054	catalytic site [active]
701521005055	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
701521005056	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788
701521005057	catalytic nucleophile [active]
701521005058	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
701521005059	active site
701521005060	tetramer interface [polypeptide binding]; other site
701521005061	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
701521005062	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
701521005063	Nucleoside recognition; Region: Gate; pfam07670
701521005064	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
701521005065	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
701521005066	DEAD_2; Region: DEAD_2; pfam06733
701521005067	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
701521005068	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
701521005069	Protein of unknown function (DUF972); Region: DUF972; pfam06156
701521005070	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
701521005071	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
701521005072	putative substrate translocation pore; other site
701521005073	TRAM domain; Region: TRAM; pfam01938
701521005074	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
701521005075	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
701521005076	S-adenosylmethionine binding site [chemical binding]; other site
701521005077	Peptidase family C69; Region: Peptidase_C69; pfam03577
701521005078	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
701521005079	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
701521005080	DNA binding residues [nucleotide binding]
701521005081	putative dimer interface [polypeptide binding]; other site
701521005082	NAD-dependent deacetylase; Provisional; Region: PRK00481
701521005083	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
701521005084	atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267
701521005085	NADH(P)-binding; Region: NAD_binding_10; pfam13460
701521005086	putative NAD(P) binding site [chemical binding]; other site
701521005087	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
701521005088	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
701521005089	Dyp-type peroxidase family; Region: Dyp_perox; cl01067
701521005090	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
701521005091	MarR family; Region: MarR_2; cl17246
701521005092	beta-phosphoglucomutase; Region: bPGM; TIGR01990
701521005093	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
701521005094	motif II; other site
701521005095	maltose phosphorylase; Provisional; Region: PRK13807
701521005096	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
701521005097	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
701521005098	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
701521005099	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
701521005100	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
701521005101	Walker A/P-loop; other site
701521005102	ATP binding site [chemical binding]; other site
701521005103	Q-loop/lid; other site
701521005104	ABC transporter signature motif; other site
701521005105	Walker B; other site
701521005106	D-loop; other site
701521005107	H-loop/switch region; other site
701521005108	TOBE domain; Region: TOBE_2; pfam08402
701521005109	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
701521005110	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
701521005111	dimer interface [polypeptide binding]; other site
701521005112	conserved gate region; other site
701521005113	putative PBP binding loops; other site
701521005114	ABC-ATPase subunit interface; other site
701521005115	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
701521005116	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
701521005117	dimer interface [polypeptide binding]; other site
701521005118	conserved gate region; other site
701521005119	putative PBP binding loops; other site
701521005120	ABC-ATPase subunit interface; other site
701521005121	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
701521005122	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
701521005123	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
701521005124	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
701521005125	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
701521005126	putative active site [active]
701521005127	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
701521005128	agmatine deiminase; Region: agmatine_aguA; TIGR03380
701521005129	carbamate kinase; Reviewed; Region: PRK12686
701521005130	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
701521005131	putative substrate binding site [chemical binding]; other site
701521005132	nucleotide binding site [chemical binding]; other site
701521005133	nucleotide binding site [chemical binding]; other site
701521005134	homodimer interface [polypeptide binding]; other site
701521005135	agmatine deiminase; Provisional; Region: PRK13551
701521005136	agmatine deiminase; Region: agmatine_aguA; TIGR03380
701521005137	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
701521005138	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
701521005139	putrescine carbamoyltransferase; Provisional; Region: PRK02255
701521005140	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
701521005141	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
701521005142	Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313
701521005143	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
701521005144	active site
701521005145	catalytic site [active]
701521005146	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
701521005147	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
701521005148	Ca binding site [ion binding]; other site
701521005149	active site
701521005150	catalytic site [active]
701521005151	Transcriptional regulators [Transcription]; Region: PurR; COG1609
701521005152	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
701521005153	DNA binding site [nucleotide binding]
701521005154	domain linker motif; other site
701521005155	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
701521005156	ligand binding site [chemical binding]; other site
701521005157	dimerization interface [polypeptide binding]; other site
701521005158	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
701521005159	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
701521005160	Uncharacterized conserved protein [Function unknown]; Region: COG3589
701521005161	Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913
701521005162	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
701521005163	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
701521005164	peptide binding site [polypeptide binding]; other site
701521005165	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
701521005166	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
701521005167	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
701521005168	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
701521005169	Restriction endonuclease FokI, recognition domain; Region: FokI_N; pfam02981
701521005170	Restriction endonuclease FokI, catalytic domain; Region: FokI_C; pfam02980
701521005171	Restriction endonuclease FokI, C terminal; Region: Endonuc-FokI_C; pfam09254
701521005172	Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG3392
701521005173	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
701521005174	Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338
701521005175	CAAX protease self-immunity; Region: Abi; pfam02517
701521005176	PemK-like protein; Region: PemK; pfam02452
701521005177	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
701521005178	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
701521005179	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
701521005180	Walker A/P-loop; other site
701521005181	ATP binding site [chemical binding]; other site
701521005182	Q-loop/lid; other site
701521005183	ABC transporter signature motif; other site
701521005184	Walker B; other site
701521005185	D-loop; other site
701521005186	H-loop/switch region; other site
701521005187	FtsX-like permease family; Region: FtsX; pfam02687
701521005188	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
701521005189	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
701521005190	active site
701521005191	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
701521005192	amphipathic channel; other site
701521005193	Asn-Pro-Ala signature motifs; other site
701521005194	phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484
701521005195	dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365
701521005196	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481
701521005197	Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376
701521005198	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
701521005199	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
701521005200	atypical (a) SDRs, subgroup 7; Region: SDR_a7; cd05262
701521005201	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
701521005202	putative NAD(P) binding site [chemical binding]; other site
701521005203	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
701521005204	Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432
701521005205	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
701521005206	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
701521005207	Protein of unknown function (DUF2974); Region: DUF2974; pfam11187
701521005208	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
701521005209	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
701521005210	NAD binding site [chemical binding]; other site
701521005211	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
701521005212	Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005
701521005213	tetramer interface [polypeptide binding]; other site
701521005214	active site
701521005215	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
701521005216	phosphate binding site [ion binding]; other site
701521005217	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
701521005218	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
701521005219	substrate binding site [chemical binding]; other site
701521005220	ATP binding site [chemical binding]; other site
701521005221	Citrate transporter; Region: CitMHS; pfam03600
701521005222	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
701521005223	Transcriptional regulators [Transcription]; Region: PurR; COG1609
701521005224	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
701521005225	DNA binding site [nucleotide binding]
701521005226	domain linker motif; other site
701521005227	Ligand-binding domain of DNA transcription repressor RegR and other putative regulators such as KdgR and EndR; Region: PBP1_RegR_EndR_KdgR_like; cd06283
701521005228	putative dimerization interface [polypeptide binding]; other site
701521005229	putative ligand binding site [chemical binding]; other site
701521005230	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
701521005231	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
701521005232	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
701521005233	Domain of unknown function (DUF1975); Region: DUF1975; pfam09318
701521005234	This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding.  In...; Region: GT1_gtfA_like; cd04949
701521005235	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
701521005236	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
701521005237	legume lectins; Region: lectin_L-type; cd01951
701521005238	homotetramer interaction site [polypeptide binding]; other site
701521005239	carbohydrate binding site [chemical binding]; other site
701521005240	metal binding site [ion binding]; metal-binding site
701521005241	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
701521005242	MarR family; Region: MarR_2; pfam12802
701521005243	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
701521005244	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
701521005245	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
701521005246	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
701521005247	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
701521005248	Walker A/P-loop; other site
701521005249	ATP binding site [chemical binding]; other site
701521005250	Q-loop/lid; other site
701521005251	ABC transporter signature motif; other site
701521005252	Walker B; other site
701521005253	D-loop; other site
701521005254	H-loop/switch region; other site
701521005255	ABC transporter; Region: ABC_tran_2; pfam12848
701521005256	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
701521005257	putative fructoselysine transporter; Provisional; Region: frlA; PRK11357
701521005258	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
701521005259	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
701521005260	Walker A/P-loop; other site
701521005261	ATP binding site [chemical binding]; other site
701521005262	Q-loop/lid; other site
701521005263	ABC transporter signature motif; other site
701521005264	Walker B; other site
701521005265	D-loop; other site
701521005266	H-loop/switch region; other site
701521005267	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
701521005268	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
701521005269	FtsX-like permease family; Region: FtsX; pfam02687
701521005270	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
701521005271	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
701521005272	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
701521005273	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
701521005274	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
701521005275	motif II; other site
701521005276	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
701521005277	short chain dehydrogenase; Validated; Region: PRK06182
701521005278	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
701521005279	NADP binding site [chemical binding]; other site
701521005280	active site
701521005281	steroid binding site; other site
701521005282	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
701521005283	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
701521005284	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
701521005285	dimer interface [polypeptide binding]; other site
701521005286	conserved gate region; other site
701521005287	putative PBP binding loops; other site
701521005288	ABC-ATPase subunit interface; other site
701521005289	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
701521005290	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
701521005291	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
701521005292	dimer interface [polypeptide binding]; other site
701521005293	conserved gate region; other site
701521005294	putative PBP binding loops; other site
701521005295	ABC-ATPase subunit interface; other site
701521005296	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
701521005297	ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295
701521005298	Walker A/P-loop; other site
701521005299	ATP binding site [chemical binding]; other site
701521005300	Q-loop/lid; other site
701521005301	ABC transporter signature motif; other site
701521005302	Walker B; other site
701521005303	D-loop; other site
701521005304	H-loop/switch region; other site
701521005305	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
701521005306	Porcine testicular carbonyl reductase (PTCR)-like, classical (c) SDRs; Region: carb_red_PTCR-like_SDR_c; cd05324
701521005307	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
701521005308	NADP binding site [chemical binding]; other site
701521005309	substrate binding site [chemical binding]; other site
701521005310	active site
701521005311	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
701521005312	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
701521005313	DNA binding residues [nucleotide binding]
701521005314	putative dimer interface [polypeptide binding]; other site
701521005315	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
701521005316	peptidase T; Region: peptidase-T; TIGR01882
701521005317	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
701521005318	metal binding site [ion binding]; metal-binding site
701521005319	dimer interface [polypeptide binding]; other site
701521005320	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
701521005321	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
701521005322	Phosphotransferase system IIB components [Carbohydrate transport and metabolism]; Region: PtsG; COG1264
701521005323	active site turn [active]
701521005324	phosphorylation site [posttranslational modification]
701521005325	Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190
701521005326	HPr interaction site; other site
701521005327	glycerol kinase (GK) interaction site [polypeptide binding]; other site
701521005328	active site
701521005329	phosphorylation site [posttranslational modification]
701521005330	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
701521005331	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
701521005332	Ligand Binding Site [chemical binding]; other site
701521005333	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
701521005334	amphipathic channel; other site
701521005335	Asn-Pro-Ala signature motifs; other site
701521005336	Protein of unknown function DUF111; Region: DUF111; pfam01969
701521005337	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
701521005338	AIR carboxylase; Region: AIRC; smart01001
701521005339	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
701521005340	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
701521005341	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cl00047
701521005342	ligand binding site [chemical binding]; other site
701521005343	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
701521005344	putative switch regulator; other site
701521005345	non-specific DNA interactions [nucleotide binding]; other site
701521005346	DNA binding site [nucleotide binding]
701521005347	sequence specific DNA binding site [nucleotide binding]; other site
701521005348	putative cAMP binding site [chemical binding]; other site
701521005349	High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376
701521005350	putative oxidoreductase; Provisional; Region: PRK10206
701521005351	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
701521005352	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
701521005353	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
701521005354	active site
701521005355	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
701521005356	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
701521005357	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
701521005358	Protein export membrane protein; Region: SecD_SecF; cl14618
701521005359	Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349
701521005360	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
701521005361	plasma-membrane proton-efflux P-type ATPase; Region: ATPase-IIIA_H; TIGR01647
701521005362	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
701521005363	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
701521005364	motif II; other site
701521005365	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
701521005366	endonuclease III; Region: ENDO3c; smart00478
701521005367	minor groove reading motif; other site
701521005368	helix-hairpin-helix signature motif; other site
701521005369	substrate binding pocket [chemical binding]; other site
701521005370	active site
701521005371	Peptidase family C69; Region: Peptidase_C69; pfam03577
701521005372	classical (c) SDRs; Region: SDR_c; cd05233
701521005373	Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561
701521005374	NAD(P) binding site [chemical binding]; other site
701521005375	active site
701521005376	Transcriptional regulators [Transcription]; Region: MarR; COG1846
701521005377	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
701521005378	dimerization interface [polypeptide binding]; other site
701521005379	putative DNA binding site [nucleotide binding]; other site
701521005380	putative Zn2+ binding site [ion binding]; other site
701521005381	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
701521005382	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
701521005383	non-specific DNA binding site [nucleotide binding]; other site
701521005384	salt bridge; other site
701521005385	sequence-specific DNA binding site [nucleotide binding]; other site
701521005386	Cna protein B-type domain; Region: Cna_B; pfam05738
701521005387	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
701521005388	domain interaction interfaces [polypeptide binding]; other site
701521005389	Cna protein B-type domain; Region: Cna_B; pfam05738
701521005390	Repeat unit of collagen-binding protein domain B; Region: CollagenBindB; cd00222
701521005391	domain interaction interfaces [polypeptide binding]; other site
701521005392	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
701521005393	Protein of unknown function (DUF1211); Region: DUF1211; cl01421
701521005394	Permeases of the major facilitator superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / Inorganic ion transport and metabolism / General function prediction only]; Region: ProP; COG0477
701521005395	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
701521005396	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
701521005397	NAD(P) binding site [chemical binding]; other site
701521005398	active site
701521005399	hypothetical protein; Provisional; Region: PRK07329
701521005400	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
701521005401	active site
701521005402	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
701521005403	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
701521005404	nucleotide binding site [chemical binding]; other site
701521005405	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
701521005406	beta-galactosidase; Region: BGL; TIGR03356
701521005407	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
701521005408	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
701521005409	Protein of unknown function (DUF805); Region: DUF805; pfam05656
701521005410	Predicted membrane protein [Function unknown]; Region: COG1511
701521005411	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
701521005412	X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057
701521005413	Predicted membrane protein [Function unknown]; Region: COG1511
701521005414	YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062
701521005415	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
701521005416	dimerization interface [polypeptide binding]; other site
701521005417	putative DNA binding site [nucleotide binding]; other site
701521005418	putative Zn2+ binding site [ion binding]; other site
701521005419	EDD domain protein, DegV family; Region: DegV; TIGR00762
701521005420	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
701521005421	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
701521005422	nucleotide binding site/active site [active]
701521005423	HIT family signature motif; other site
701521005424	catalytic residue [active]
701521005425	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
701521005426	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
701521005427	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
701521005428	substrate binding site [chemical binding]; other site
701521005429	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
701521005430	hypothetical protein; Provisional; Region: PRK10621
701521005431	Protein of unknown function (DUF328); Region: DUF328; pfam03883
701521005432	classical (c) SDRs; Region: SDR_c; cd05233
701521005433	NAD(P) binding site [chemical binding]; other site
701521005434	active site
701521005435	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
701521005436	catalytic core [active]
701521005437	BCCT family transporter; Region: BCCT; pfam02028
701521005438	maltose O-acetyltransferase; Provisional; Region: PRK10092
701521005439	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
701521005440	active site
701521005441	substrate binding site [chemical binding]; other site
701521005442	trimer interface [polypeptide binding]; other site
701521005443	CoA binding site [chemical binding]; other site
701521005444	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
701521005445	catalytic residue [active]
701521005446	Sigma-70, region 4; Region: Sigma70_r4; pfam04545
701521005447	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
701521005448	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
701521005449	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
701521005450	protein binding site [polypeptide binding]; other site
701521005451	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
701521005452	YycH protein; Region: YycI; pfam09648
701521005453	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863
701521005454	YycH protein; Region: YycH; pfam07435
701521005455	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
701521005456	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
701521005457	dimerization interface [polypeptide binding]; other site
701521005458	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
701521005459	putative active site [active]
701521005460	heme pocket [chemical binding]; other site
701521005461	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
701521005462	dimer interface [polypeptide binding]; other site
701521005463	phosphorylation site [posttranslational modification]
701521005464	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
701521005465	ATP binding site [chemical binding]; other site
701521005466	Mg2+ binding site [ion binding]; other site
701521005467	G-X-G motif; other site
701521005468	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
701521005469	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
701521005470	active site
701521005471	phosphorylation site [posttranslational modification]
701521005472	intermolecular recognition site; other site
701521005473	dimerization interface [polypeptide binding]; other site
701521005474	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
701521005475	DNA binding site [nucleotide binding]
701521005476	Aminopeptidase N [Amino acid transport and metabolism]; Region: PepN; COG0308
701521005477	Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601
701521005478	Zn binding site [ion binding]; other site
701521005479	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
701521005480	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
701521005481	Protein of unknown function (DUF1093); Region: DUF1093; pfam06486
701521005482	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
701521005483	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
701521005484	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
701521005485	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
701521005486	ribitol-5-phosphate dehydrogenase; Region: ribitol-5-phosphate_DH; cd08237
701521005487	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
701521005488	putative NAD(P) binding site [chemical binding]; other site
701521005489	putative catalytic Zn binding site [ion binding]; other site
701521005490	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
701521005491	substrate binding site; other site
701521005492	dimer interface; other site
701521005493	Isochorismatase family; Region: Isochorismatase; pfam00857
701521005494	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
701521005495	catalytic triad [active]
701521005496	conserved cis-peptide bond; other site
701521005497	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
701521005498	Coenzyme A binding pocket [chemical binding]; other site
701521005499	Colicin V production protein; Region: Colicin_V; pfam02674
701521005500	Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110
701521005501	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
701521005502	Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579
701521005503	putative active site [active]
701521005504	catalytic site [active]
701521005505	putative metal binding site [ion binding]; other site
701521005506	Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028
701521005507	Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523
701521005508	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
701521005509	Coenzyme A binding pocket [chemical binding]; other site
701521005510	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
701521005511	Part of AAA domain; Region: AAA_19; pfam13245
701521005512	Family description; Region: UvrD_C_2; pfam13538
701521005513	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
701521005514	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
701521005515	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
701521005516	NADH(P)-binding; Region: NAD_binding_10; pfam13460
701521005517	xanthine permease; Region: pbuX; TIGR03173
701521005518	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
701521005519	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
701521005520	active site
701521005521	catalytic triad [active]
701521005522	oxyanion hole [active]
701521005523	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
701521005524	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
701521005525	Coenzyme A binding pocket [chemical binding]; other site
701521005526	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
701521005527	cardiolipin synthase; Region: bac_cardiolipin; TIGR04265
701521005528	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
701521005529	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
701521005530	putative active site [active]
701521005531	catalytic site [active]
701521005532	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
701521005533	putative active site [active]
701521005534	catalytic site [active]
701521005535	Diadenosine tetraphosphate (Ap4A) hydrolase and other HIT family hydrolases [Nucleotide transport and metabolism / Carbohydrate transport and metabolism / General function prediction only]; Region: Hit; COG0537
701521005536	nucleotide binding site/active site [active]
701521005537	HIT family signature motif; other site
701521005538	catalytic residue [active]
701521005539	Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585
701521005540	trimer interface [polypeptide binding]; other site
701521005541	active site
701521005542	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
701521005543	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
701521005544	Catalytic site [active]
701521005545	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
701521005546	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
701521005547	EamA-like transporter family; Region: EamA; pfam00892
701521005548	Protein of unknown function (DUF1211); Region: DUF1211; cl01421
701521005549	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
701521005550	tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137
701521005551	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
701521005552	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
701521005553	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
701521005554	trmE is a tRNA modification GTPase; Region: trmE; cd04164
701521005555	G1 box; other site
701521005556	GTP/Mg2+ binding site [chemical binding]; other site
701521005557	Switch I region; other site
701521005558	G2 box; other site
701521005559	Switch II region; other site
701521005560	G3 box; other site
701521005561	G4 box; other site
701521005562	G5 box; other site
701521005563	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
701521005564	60Kd inner membrane protein; Region: 60KD_IMP; cl00489
701521005565	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
701521005566	ribonuclease P; Reviewed; Region: rnpA; PRK00499
701521005567	Replication protein; Region: Rep_1; pfam01446
701521005568	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
701521005569	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
701521005570	salt bridge; other site
701521005571	non-specific DNA binding site [nucleotide binding]; other site
701521005572	sequence-specific DNA binding site [nucleotide binding]; other site
701521005573	Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708
701521005574	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
701521005575	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
701521005576	Transposase, Mutator family; Region: Transposase_mut; pfam00872
701521005577	MULE transposase domain; Region: MULE; pfam10551
701521005578	RelB antitoxin; Region: RelB; cl01171
701521005579	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
701521005580	Protein of unknown function (DUF3847); Region: DUF3847; pfam12958
701521005581	MobA/MobL family; Region: MobA_MobL; pfam03389
701521005582	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
701521005583	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
701521005584	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
701521005585	FOG: Glucan-binding domain (YG repeat) [General function prediction only]; Region: COG5263
701521005586	Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672
701521005587	Transposase, Mutator family; Region: Transposase_mut; pfam00872
701521005588	MULE transposase domain; Region: MULE; pfam10551
701521005589	multicopper oxidase; Provisional; Region: PRK10965
701521005590	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
701521005591	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
701521005592	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
701521005593	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
701521005594	putative substrate translocation pore; other site
701521005595	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
701521005596	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
701521005597	catalytic residues [active]
701521005598	catalytic nucleophile [active]
701521005599	Presynaptic Site I dimer interface [polypeptide binding]; other site
701521005600	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
701521005601	Synaptic Flat tetramer interface [polypeptide binding]; other site
701521005602	Synaptic Site I dimer interface [polypeptide binding]; other site
701521005603	DNA binding site [nucleotide binding]
701521005604	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
701521005605	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
701521005606	P-loop; other site
701521005607	Magnesium ion binding site [ion binding]; other site
701521005608	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
701521005609	Magnesium ion binding site [ion binding]; other site
701521005610	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
701521005611	RelB antitoxin; Region: RelB; cl01171
701521005612	Protein of unknown function (DUF3847); Region: DUF3847; pfam12958
701521005613	MobA/MobL family; Region: MobA_MobL; pfam03389
701521005614	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
701521005615	Domain of unknown function DUF87; Region: DUF87; pfam01935
701521005616	AAA-like domain; Region: AAA_10; pfam12846
701521005617	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
701521005618	N-acetyl-D-glucosamine binding site [chemical binding]; other site
701521005619	catalytic residue [active]
701521005620	NlpC/P60 family; Region: NLPC_P60; cl17555
701521005621	Protein of unknown function (DUF3251); Region: DUF3251; cl08186
701521005622	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
701521005623	catalytic residues [active]
701521005624	Type IV secretion-system coupling protein DNA-binding domain; Region: TrwB_AAD_bind; pfam10412
701521005625	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
701521005626	Walker A motif; other site
701521005627	ATP binding site [chemical binding]; other site
701521005628	Walker B motif; other site
701521005629	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
701521005630	DNA topoisomerase III; Provisional; Region: PRK07726
701521005631	active site
701521005632	putative interdomain interaction site [polypeptide binding]; other site
701521005633	putative metal-binding site [ion binding]; other site
701521005634	putative nucleotide binding site [chemical binding]; other site
701521005635	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
701521005636	domain I; other site
701521005637	DNA binding groove [nucleotide binding]
701521005638	phosphate binding site [ion binding]; other site
701521005639	domain II; other site
701521005640	domain III; other site
701521005641	nucleotide binding site [chemical binding]; other site
701521005642	catalytic site [active]
701521005643	domain IV; other site
701521005644	Domain of unknown function (DUF955); Region: DUF955; pfam06114
701521005645	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
701521005646	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
701521005647	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
701521005648	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
701521005649	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
701521005650	dimerization interface [polypeptide binding]; other site
701521005651	putative DNA binding site [nucleotide binding]; other site
701521005652	putative Zn2+ binding site [ion binding]; other site
701521005653	arsenical pump membrane protein; Provisional; Region: PRK15445
701521005654	Anion permease ArsB.  These permeases have been shown to export arsenate and antimonite in eubacteria and archaea.  A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118
701521005655	transmembrane helices; other site
701521005656	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
701521005657	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
701521005658	catalytic residues [active]
701521005659	catalytic nucleophile [active]
701521005660	Presynaptic Site I dimer interface [polypeptide binding]; other site
701521005661	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
701521005662	Synaptic Flat tetramer interface [polypeptide binding]; other site
701521005663	Synaptic Site I dimer interface [polypeptide binding]; other site
701521005664	DNA binding site [nucleotide binding]
701521005665	KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715
701521005666	legume lectins; Region: lectin_L-type; cl14058
701521005667	homotetramer interaction site [polypeptide binding]; other site
701521005668	carbohydrate binding site [chemical binding]; other site
701521005669	metal binding site [ion binding]; metal-binding site
701521005670	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
701521005671	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
701521005672	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
701521005673	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
701521005674	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
701521005675	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
701521005676	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
701521005677	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
701521005678	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
701521005679	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
701521005680	Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461
701521005681	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
701521005682	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
701521005683	multiple promoter invertase; Provisional; Region: mpi; PRK13413
701521005684	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
701521005685	catalytic residues [active]
701521005686	catalytic nucleophile [active]
701521005687	Presynaptic Site I dimer interface [polypeptide binding]; other site
701521005688	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
701521005689	Synaptic Flat tetramer interface [polypeptide binding]; other site
701521005690	Synaptic Site I dimer interface [polypeptide binding]; other site
701521005691	DNA binding site [nucleotide binding]
701521005692	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
701521005693	DNA-binding interface [nucleotide binding]; DNA binding site
701521005694	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
701521005695	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
701521005696	P-loop; other site
701521005697	Magnesium ion binding site [ion binding]; other site
701521005698	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
701521005699	Magnesium ion binding site [ion binding]; other site
701521005700	Plasmid replication protein; Region: Rep_2; pfam01719
701521005701	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
701521005702	Initiator Replication protein; Region: Rep_3; pfam01051
701521005703	HTH domain; Region: HTH_11; cl17392
701521005704	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
701521005705	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
701521005706	dimerization interface [polypeptide binding]; other site
701521005707	DPS ferroxidase diiron center [ion binding]; other site
701521005708	ion pore; other site
701521005709	BacA is a bacterial lysin from Enterococcus faecalis that degrades bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues. BacA is homologous to the YbfG and YkuG lysins of...; Region: GH25_BacA-like; cd06418
701521005710	active site
701521005711	PemK-like protein; Region: PemK; pfam02452
701521005712	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
701521005713	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
701521005714	active site
701521005715	DNA binding site [nucleotide binding]
701521005716	Int/Topo IB signature motif; other site
701521005717	Initiator Replication protein; Region: Rep_3; pfam01051
701521005718	HTH domain; Region: HTH_11; cl17392
701521005719	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
701521005720	Helix-turn-helix domain; Region: HTH_38; pfam13936
701521005721	Integrase core domain; Region: rve; pfam00665
701521005722	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
701521005723	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
701521005724	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
701521005725	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
701521005726	Enterocin A Immunity; Region: EntA_Immun; pfam08951
701521005727	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
701521005728	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
701521005729	INT_SG3, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 3, catalytic domain. The CD contains various predicted bacterial and phage integrase/recombinase sequences for which not much experimental characterization is available; Region: INT_SG3_C; cd01186
701521005730	Int/Topo IB signature motif; other site
701521005731	MobA/MobL family; Region: MobA_MobL; pfam03389
701521005732	Protein of unknown function (DUF3847); Region: DUF3847; pfam12958
701521005733	Zeta toxin; Region: Zeta_toxin; pfam06414
701521005734	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
701521005735	RelB antitoxin; Region: RelB; cl01171
701521005736	Replication initiator protein A (RepA) N-terminus; Region: RepA_N; pfam06970
701521005737	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
701521005738	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
701521005739	P-loop; other site
701521005740	Magnesium ion binding site [ion binding]; other site
701521005741	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
701521005742	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
701521005743	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
701521005744	catalytic residues [active]
701521005745	catalytic nucleophile [active]
701521005746	Presynaptic Site I dimer interface [polypeptide binding]; other site
701521005747	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
701521005748	Synaptic Flat tetramer interface [polypeptide binding]; other site
701521005749	Synaptic Site I dimer interface [polypeptide binding]; other site
701521005750	DNA binding site [nucleotide binding]
701521005751	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
701521005752	DNA-binding interface [nucleotide binding]; DNA binding site
701521005753	type 2 lantibiotic biosynthesis protein LanM; Region: lanti_2_LanM; TIGR03897
701521005754	LanM-like proteins. LanM is a bifunctional enzyme, involved in the synthesis of class II lantibiotics. It is responsible for both the dehydration and the cyclization of the precursor-peptide during lantibiotic synthesis. The C-terminal domain shows...; Region: LanM-like; cd04792
701521005755	active site
701521005756	zinc binding site [ion binding]; other site
701521005757	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296
701521005758	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
701521005759	putative active site [active]
701521005760	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
701521005761	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
701521005762	Walker A/P-loop; other site
701521005763	ATP binding site [chemical binding]; other site
701521005764	Q-loop/lid; other site
701521005765	ABC transporter signature motif; other site
701521005766	Walker B; other site
701521005767	D-loop; other site
701521005768	H-loop/switch region; other site
701521005769	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
701521005770	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
701521005771	Walker A/P-loop; other site
701521005772	ATP binding site [chemical binding]; other site
701521005773	Q-loop/lid; other site
701521005774	ABC transporter signature motif; other site
701521005775	Walker B; other site
701521005776	D-loop; other site
701521005777	H-loop/switch region; other site
701521005778	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
701521005779	ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730
701521005780	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
701521005781	Helix-turn-helix domain; Region: HTH_38; pfam13936
701521005782	Integrase core domain; Region: rve; pfam00665
701521005783	Transposase, Mutator family; Region: Transposase_mut; pfam00872
701521005784	Transposase, Mutator family; Region: Transposase_mut; pfam00872
701521005785	transposase/IS protein; Provisional; Region: PRK09183
701521005786	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
701521005787	Walker A motif; other site
701521005788	ATP binding site [chemical binding]; other site
701521005789	Walker B motif; other site
701521005790	arginine finger; other site
701521005791	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
701521005792	Integrase core domain; Region: rve; pfam00665
701521005793	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
701521005794	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
701521005795	active site
701521005796	DNA binding site [nucleotide binding]
701521005797	Int/Topo IB signature motif; other site
701521005798	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
701521005799	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
701521005800	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
701521005801	putative substrate translocation pore; other site
701521005802	H+ Antiporter protein; Region: 2A0121; TIGR00900
701521005803	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
701521005804	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
701521005805	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
701521005806	motif II; other site
701521005807	copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698
701521005808	Penicillinase repressor; Region: Pencillinase_R; pfam03965
701521005809	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
701521005810	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
701521005811	Helix-turn-helix domain; Region: HTH_38; pfam13936
701521005812	Integrase core domain; Region: rve; pfam00665
701521005813	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
701521005814	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
701521005815	active site
701521005816	Initiator Replication protein; Region: Rep_3; pfam01051
701521005817	Primase C terminal 1 (PriCT-1); Region: PriCT_1; pfam08708
701521005818	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
701521005819	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
701521005820	P-loop; other site
701521005821	Magnesium ion binding site [ion binding]; other site
701521005822	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
701521005823	Magnesium ion binding site [ion binding]; other site
701521005824	multiple promoter invertase; Provisional; Region: mpi; PRK13413
701521005825	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
701521005826	catalytic residues [active]
701521005827	catalytic nucleophile [active]
701521005828	Presynaptic Site I dimer interface [polypeptide binding]; other site
701521005829	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
701521005830	Synaptic Flat tetramer interface [polypeptide binding]; other site
701521005831	Synaptic Site I dimer interface [polypeptide binding]; other site
701521005832	DNA binding site [nucleotide binding]
701521005833	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
701521005834	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
701521005835	putative acyl-acceptor binding pocket; other site
701521005836	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
701521005837	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
701521005838	Ligand binding site; other site
701521005839	metal-binding site
701521005840	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
701521005841	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
701521005842	putative acyl-acceptor binding pocket; other site
701521005843	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
701521005844	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
701521005845	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
701521005846	Walker A/P-loop; other site
701521005847	ATP binding site [chemical binding]; other site
701521005848	Q-loop/lid; other site
701521005849	ABC transporter signature motif; other site
701521005850	Walker B; other site
701521005851	D-loop; other site
701521005852	H-loop/switch region; other site
701521005853	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
701521005854	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
701521005855	active site
701521005856	DNA polymerase IV; Reviewed; Region: PRK03103
701521005857	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
701521005858	active site
701521005859	DNA binding site [nucleotide binding]
701521005860	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
701521005861	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
701521005862	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
701521005863	non-specific DNA binding site [nucleotide binding]; other site
701521005864	salt bridge; other site
701521005865	sequence-specific DNA binding site [nucleotide binding]; other site
701521005866	Protein of unknown function (DUF1093); Region: DUF1093; cl02185
701521005867	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
701521005868	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
701521005869	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
701521005870	ATP binding site [chemical binding]; other site
701521005871	putative Mg++ binding site [ion binding]; other site
701521005872	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
701521005873	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
701521005874	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
701521005875	Domain of unknown function (DUF955); Region: DUF955; cl01076
701521005876	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
701521005877	DNA topoisomerase III; Provisional; Region: PRK07726
701521005878	active site
701521005879	putative interdomain interaction site [polypeptide binding]; other site
701521005880	putative metal-binding site [ion binding]; other site
701521005881	putative nucleotide binding site [chemical binding]; other site
701521005882	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
701521005883	domain I; other site
701521005884	DNA binding groove [nucleotide binding]
701521005885	phosphate binding site [ion binding]; other site
701521005886	domain II; other site
701521005887	domain III; other site
701521005888	nucleotide binding site [chemical binding]; other site
701521005889	catalytic site [active]
701521005890	domain IV; other site
701521005891	C-terminal repeat of topoisomerase; Region: Toprim_Crpt; pfam13342
701521005892	MobA/MobL family; Region: MobA_MobL; pfam03389
701521005893	Protein of unknown function (DUF3847); Region: DUF3847; pfam12958
701521005894	Integrase core domain; Region: rve; pfam00665
701521005895	Integrase core domain; Region: rve_2; pfam13333
701521005896	Helix-turn-helix domain; Region: HTH_28; pfam13518
701521005897	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
701521005898	Helix-turn-helix domain; Region: HTH_28; pfam13518