-- dump date 20140619_232521 -- class Genbank::misc_feature -- table misc_feature_note -- id note 278197000001 chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149 278197000002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278197000003 Walker A motif; other site 278197000004 ATP binding site [chemical binding]; other site 278197000005 Walker B motif; other site 278197000006 arginine finger; other site 278197000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 278197000008 DnaA box-binding interface [nucleotide binding]; other site 278197000009 DNA polymerase III subunit beta; Validated; Region: PRK05643 278197000010 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 278197000011 putative DNA binding surface [nucleotide binding]; other site 278197000012 dimer interface [polypeptide binding]; other site 278197000013 beta-clamp/clamp loader binding surface; other site 278197000014 beta-clamp/translesion DNA polymerase binding surface; other site 278197000015 S4 domain protein YaaA; Region: YaaA_near_RecF; TIGR02988 278197000016 recombination protein F; Reviewed; Region: recF; PRK00064 278197000017 ATP-binding cassette domain of RecF; Region: ABC_RecF; cd03242 278197000018 Walker A/P-loop; other site 278197000019 ATP binding site [chemical binding]; other site 278197000020 Q-loop/lid; other site 278197000021 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 278197000022 ABC transporter signature motif; other site 278197000023 Walker B; other site 278197000024 D-loop; other site 278197000025 H-loop/switch region; other site 278197000026 DNA gyrase subunit B; Validated; Region: gyrB; PRK05644 278197000027 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278197000028 Mg2+ binding site [ion binding]; other site 278197000029 G-X-G motif; other site 278197000030 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 278197000031 anchoring element; other site 278197000032 dimer interface [polypeptide binding]; other site 278197000033 ATP binding site [chemical binding]; other site 278197000034 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 278197000035 active site 278197000036 metal binding site [ion binding]; metal-binding site 278197000037 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 278197000038 DNA gyrase subunit A; Validated; Region: PRK05560 278197000039 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 278197000040 CAP-like domain; other site 278197000041 active site 278197000042 primary dimer interface [polypeptide binding]; other site 278197000043 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 278197000044 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 278197000045 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 278197000046 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 278197000047 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 278197000048 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 278197000049 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 278197000050 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 278197000051 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 278197000052 dimer interface [polypeptide binding]; other site 278197000053 ssDNA binding site [nucleotide binding]; other site 278197000054 tetramer (dimer of dimers) interface [polypeptide binding]; other site 278197000055 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 278197000056 Predicted signaling protein consisting of a modified GGDEF domain and a DHH domain [Signal transduction mechanisms]; Region: COG3887 278197000057 PAS domain; Region: PAS; smart00091 278197000058 Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967 278197000059 DHH family; Region: DHH; pfam01368 278197000060 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 278197000061 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 278197000062 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 278197000063 replicative DNA helicase; Provisional; Region: PRK05748 278197000064 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 278197000065 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 278197000066 Walker A motif; other site 278197000067 ATP binding site [chemical binding]; other site 278197000068 Walker B motif; other site 278197000069 DNA binding loops [nucleotide binding] 278197000070 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197000071 Major Facilitator Superfamily; Region: MFS_1; pfam07690 278197000072 putative substrate translocation pore; other site 278197000073 Protein of unknown function (DUF1304); Region: DUF1304; pfam06993 278197000074 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 278197000075 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 278197000076 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 278197000077 ABC transporter; Region: ABC_tran_2; pfam12848 278197000078 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 278197000079 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278197000080 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 278197000081 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 278197000082 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 278197000083 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 278197000084 Walker A/P-loop; other site 278197000085 ATP binding site [chemical binding]; other site 278197000086 Q-loop/lid; other site 278197000087 ABC transporter signature motif; other site 278197000088 Walker B; other site 278197000089 D-loop; other site 278197000090 H-loop/switch region; other site 278197000091 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 278197000092 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 278197000093 non-specific DNA binding site [nucleotide binding]; other site 278197000094 salt bridge; other site 278197000095 sequence-specific DNA binding site [nucleotide binding]; other site 278197000096 Protein of unknown function (DUF1700); Region: DUF1700; pfam08006 278197000097 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 278197000098 Sterol carrier protein domain; Region: SCP2_2; pfam13530 278197000099 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 278197000100 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 278197000101 Predicted transcriptional regulators [Transcription]; Region: COG1733 278197000102 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 278197000103 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 278197000104 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 278197000105 active site 278197000106 catalytic tetrad [active] 278197000107 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 278197000108 classical (c) SDRs; Region: SDR_c; cd05233 278197000109 NAD(P) binding site [chemical binding]; other site 278197000110 active site 278197000111 Predicted flavoprotein [General function prediction only]; Region: COG0431 278197000112 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 278197000113 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 278197000114 dimerization interface [polypeptide binding]; other site 278197000115 putative DNA binding site [nucleotide binding]; other site 278197000116 putative Zn2+ binding site [ion binding]; other site 278197000117 Predicted permease, cadmium resistance protein [Inorganic ion transport and metabolism]; Region: CadD; COG4300 278197000118 Cadmium resistance transporter; Region: Cad; pfam03596 278197000119 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 278197000120 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 278197000121 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 278197000122 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 278197000123 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 278197000124 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 278197000125 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 278197000126 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 278197000127 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 278197000128 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 278197000129 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 278197000130 Haemolysin-III related; Region: HlyIII; cl03831 278197000131 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 278197000132 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 278197000133 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 278197000134 Coenzyme A binding pocket [chemical binding]; other site 278197000135 Sodium:dicarboxylate symporter family; Region: SDF; cl00573 278197000136 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 278197000137 Membrane domain of glycerophosphoryl diester phosphodiesterase; Region: GPDPase_memb; pfam10110 278197000138 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 278197000139 Glycerophosphodiester phosphodiesterase domain of uncharacterized bacterial glycerophosphodiester phosphodiesterases; Region: GDPD_memb_like; cd08579 278197000140 putative active site [active] 278197000141 catalytic site [active] 278197000142 putative metal binding site [ion binding]; other site 278197000143 Colicin V production protein; Region: Colicin_V; pfam02674 278197000144 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 278197000145 Nodulin-21 and CCC1-related protein family; Region: Nodulin-21_like_1; cd02432 278197000146 manganese transport protein MntH; Reviewed; Region: PRK00701 278197000147 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 278197000148 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 278197000149 Ligand Binding Site [chemical binding]; other site 278197000150 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 278197000151 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 278197000152 Transcriptional regulator [Transcription]; Region: LysR; COG0583 278197000153 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 278197000154 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 278197000155 dimerization interface [polypeptide binding]; other site 278197000156 maltose O-acetyltransferase; Provisional; Region: PRK10092 278197000157 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 278197000158 trimer interface [polypeptide binding]; other site 278197000159 active site 278197000160 substrate binding site [chemical binding]; other site 278197000161 CoA binding site [chemical binding]; other site 278197000162 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 278197000163 classical (c) SDRs; Region: SDR_c; cd05233 278197000164 NAD(P) binding site [chemical binding]; other site 278197000165 active site 278197000166 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 278197000167 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 278197000168 active site 278197000169 catalytic tetrad [active] 278197000170 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 278197000171 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 278197000172 Walker A/P-loop; other site 278197000173 ATP binding site [chemical binding]; other site 278197000174 Q-loop/lid; other site 278197000175 ABC transporter signature motif; other site 278197000176 Walker B; other site 278197000177 D-loop; other site 278197000178 H-loop/switch region; other site 278197000179 Predicted transcriptional regulators [Transcription]; Region: COG1725 278197000180 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278197000181 DNA-binding site [nucleotide binding]; DNA binding site 278197000182 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 278197000183 Double zinc ribbon; Region: DZR; pfam12773 278197000184 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 278197000185 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 278197000186 Double zinc ribbon; Region: DZR; pfam12773 278197000187 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 278197000188 Penicillin V acylase (PVA), also known as conjugated bile salt acid hydrolase (CBAH), catalyzes the hydrolysis of penicillin V to yield 6-amino penicillanic acid (6-APA), an important key intermediate of semisynthetic penicillins. PVA has an N-terminal...; Region: Ntn_PVA; cd00542 278197000189 active site 278197000190 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 278197000191 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 278197000192 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 278197000193 DNA binding residues [nucleotide binding] 278197000194 putative dimer interface [polypeptide binding]; other site 278197000195 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 278197000196 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 278197000197 active site 278197000198 catalytic tetrad [active] 278197000199 accessory Sec system translocase SecA2; Region: secA2; TIGR03714 278197000200 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 278197000201 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK12417 278197000202 SecY translocase; Region: SecY; pfam00344 278197000203 accessory Sec system protein Asp1; Region: acc_sec_asp1; TIGR03713 278197000204 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 278197000205 accessory Sec system protein Asp2; Region: acc_sec_asp2; TIGR03712 278197000206 accessory Sec system protein Asp3; Region: acc_sec_asp3; TIGR03711 278197000207 accessory Sec system glycosylation protein GtfA; Region: TIGR02918 278197000208 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 278197000209 Cna protein B-type domain; Region: Cna_B; pfam05738 278197000210 LPXTG-motif cell wall anchor domain; Region: LPXTG_anchor; TIGR01167 278197000211 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 278197000212 Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304 278197000213 glucose-1-dehydrogenase; Provisional; Region: PRK08936 278197000214 glucose 1 dehydrogenase (GlcDH), classical (c) SDRs; Region: GlcDH_SDR_c; cd05358 278197000215 NAD binding site [chemical binding]; other site 278197000216 homodimer interface [polypeptide binding]; other site 278197000217 active site 278197000218 Transcriptional regulator [Transcription]; Region: LysR; COG0583 278197000219 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 278197000220 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 278197000221 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 278197000222 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 278197000223 active site 278197000224 catalytic tetrad [active] 278197000225 formaldehyde dehydrogenase (FDH)-like; Region: FDH_like_ADH3; cd08287 278197000226 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 278197000227 catalytic Zn binding site [ion binding]; other site 278197000228 NAD(P) binding site [chemical binding]; other site 278197000229 structural Zn binding site [ion binding]; other site 278197000230 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cl00162 278197000231 HPr interaction site; other site 278197000232 glycerol kinase (GK) interaction site [polypeptide binding]; other site 278197000233 active site 278197000234 phosphorylation site [posttranslational modification] 278197000235 CAT RNA binding domain; Region: CAT_RBD; cl03904 278197000236 transcriptional antiterminator BglG; Provisional; Region: PRK09772 278197000237 PRD domain; Region: PRD; pfam00874 278197000238 PRD domain; Region: PRD; pfam00874 278197000239 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 278197000240 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 278197000241 active site turn [active] 278197000242 phosphorylation site [posttranslational modification] 278197000243 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 278197000244 uncharacterized YdjC-like family proteins from bacteria; Region: YdjC_like_1; cd10805 278197000245 putative active site [active] 278197000246 YdjC motif; other site 278197000247 Mg binding site [ion binding]; other site 278197000248 putative homodimer interface [polypeptide binding]; other site 278197000249 Enterocin A Immunity; Region: EntA_Immun; pfam08951 278197000250 Class II bacteriocin; Region: Bacteriocin_II; pfam01721 278197000251 Predicted signal transduction protein with a C-terminal ATPase domain [Signal transduction mechanisms]; Region: COG2972 278197000252 Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518 278197000253 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 278197000254 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278197000255 active site 278197000256 phosphorylation site [posttranslational modification] 278197000257 intermolecular recognition site; other site 278197000258 dimerization interface [polypeptide binding]; other site 278197000259 LytTr DNA-binding domain; Region: LytTR; pfam04397 278197000260 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39B; cd02418 278197000261 ABC-type bacteriocin transporter; Region: bacteriocin_ABC; TIGR01193 278197000262 putative active site [active] 278197000263 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 278197000264 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 278197000265 Walker A/P-loop; other site 278197000266 ATP binding site [chemical binding]; other site 278197000267 Q-loop/lid; other site 278197000268 ABC transporter signature motif; other site 278197000269 Walker B; other site 278197000270 D-loop; other site 278197000271 H-loop/switch region; other site 278197000272 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 278197000273 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 278197000274 intersubunit interface [polypeptide binding]; other site 278197000275 putative acetyltransferase YhhY; Provisional; Region: PRK10140 278197000276 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 278197000277 Coenzyme A binding pocket [chemical binding]; other site 278197000278 heavy metal-(Cd/Co/Hg/Pb/Zn)-translocating P-type ATPase; Region: ATPase-IB2_Cd; TIGR01512 278197000279 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 278197000280 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 278197000281 Soluble P-type ATPase [General function prediction only]; Region: COG4087 278197000282 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 278197000283 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 278197000284 transcriptional regulator MurR; Provisional; Region: PRK15482 278197000285 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 278197000286 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 278197000287 putative active site [active] 278197000288 putative oxidoreductase; Provisional; Region: PRK10206 278197000289 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 278197000290 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 278197000291 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 278197000292 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 278197000293 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 278197000294 maltose O-acetyltransferase; Provisional; Region: PRK10092 278197000295 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 278197000296 active site 278197000297 substrate binding site [chemical binding]; other site 278197000298 trimer interface [polypeptide binding]; other site 278197000299 CoA binding site [chemical binding]; other site 278197000300 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 278197000301 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278197000302 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 278197000303 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 278197000304 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 278197000305 Alpha/beta hydrolase of unknown function (DUF915); Region: DUF915; pfam06028 278197000306 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 278197000307 catalytic residues [active] 278197000308 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 278197000309 N-glycosyltransferase; Provisional; Region: PRK11204 278197000310 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 278197000311 DXD motif; other site 278197000312 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 278197000313 beta-galactosidase; Region: BGL; TIGR03356 278197000314 hypothetical protein; Provisional; Region: PRK07329 278197000315 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 278197000316 active site 278197000317 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08588 278197000318 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 278197000319 metal binding site [ion binding]; metal-binding site 278197000320 dimer interface [polypeptide binding]; other site 278197000321 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 278197000322 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 278197000323 active site 278197000324 catalytic tetrad [active] 278197000325 galactokinase; Provisional; Region: PRK05322 278197000326 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 278197000327 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 278197000328 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 278197000329 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 278197000330 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 278197000331 KxYKxGKxW signal peptide; Region: KxYKxGKxW; TIGR03715 278197000332 MucBP domain; Region: MucBP; pfam06458 278197000333 MucBP domain; Region: MucBP; pfam06458 278197000334 MucBP domain; Region: MucBP; pfam06458 278197000335 MucBP domain; Region: MucBP; pfam06458 278197000336 MucBP domain; Region: MucBP; pfam06458 278197000337 MucBP domain; Region: MucBP; pfam06458 278197000338 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 278197000339 CCC1-related family of proteins; Region: CCC1_like; cl00278 278197000340 Cell wall-active antibiotics response protein (DUF2154); Region: DUF2154; pfam09922 278197000341 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 278197000342 LytTr DNA-binding domain; Region: LytTR; smart00850 278197000343 Cell-wall surface anchor repeat; Region: C-term_anchor; pfam13461 278197000344 Beta-lactamase; Region: Beta-lactamase; pfam00144 278197000345 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 278197000346 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 278197000347 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 278197000348 DXD motif; other site 278197000349 Collagen binding domain; Region: Collagen_bind; pfam05737 278197000350 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197000351 Major Facilitator Superfamily; Region: MFS_1; pfam07690 278197000352 putative substrate translocation pore; other site 278197000353 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 278197000354 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 278197000355 aromatic amino acid aminotransferase; Validated; Region: PRK07309 278197000356 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 278197000357 pyridoxal 5'-phosphate binding site [chemical binding]; other site 278197000358 homodimer interface [polypeptide binding]; other site 278197000359 catalytic residue [active] 278197000360 dihydrodipicolinate reductase; Provisional; Region: PRK00048 278197000361 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 278197000362 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 278197000363 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 278197000364 dihydrodipicolinate synthase; Region: dapA; TIGR00674 278197000365 dimer interface [polypeptide binding]; other site 278197000366 active site 278197000367 catalytic residue [active] 278197000368 M20 Peptidase Aminoacyclase-1 YkuR-like proteins, including YkuR and Ama/HipO/HyuC proteins; Region: M20_Acy1_YkuR_like; cd05670 278197000369 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 278197000370 metal binding site [ion binding]; metal-binding site 278197000371 putative dimer interface [polypeptide binding]; other site 278197000372 Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503 278197000373 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532 278197000374 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 278197000375 putative trimer interface [polypeptide binding]; other site 278197000376 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 278197000377 putative trimer interface [polypeptide binding]; other site 278197000378 putative CoA binding site [chemical binding]; other site 278197000379 diaminopimelate decarboxylase; Region: lysA; TIGR01048 278197000380 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 278197000381 active site 278197000382 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 278197000383 substrate binding site [chemical binding]; other site 278197000384 catalytic residues [active] 278197000385 dimer interface [polypeptide binding]; other site 278197000386 aspartate kinase; Reviewed; Region: PRK09034 278197000387 AAK_AKiii-YclM-BS: Amino Acid Kinase Superfamily (AAK), AKiii-YclM-BS; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII, a monofunctional class enzyme found in...; Region: AAK_AKiii-YclM-BS; cd04245 278197000388 putative catalytic residues [active] 278197000389 putative nucleotide binding site [chemical binding]; other site 278197000390 putative aspartate binding site [chemical binding]; other site 278197000391 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 278197000392 allosteric regulatory residue; other site 278197000393 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_2; cd04916 278197000394 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 278197000395 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 278197000396 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 278197000397 Cyanate permease [Inorganic ion transport and metabolism]; Region: CynX; COG2807 278197000398 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197000399 putative substrate translocation pore; other site 278197000400 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 278197000401 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 278197000402 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 278197000403 putative active site [active] 278197000404 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 278197000405 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 278197000406 putative substrate binding site [chemical binding]; other site 278197000407 putative ATP binding site [chemical binding]; other site 278197000408 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 278197000409 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 278197000410 active site 278197000411 P-loop; other site 278197000412 phosphorylation site [posttranslational modification] 278197000413 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 278197000414 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 278197000415 active site 278197000416 phosphorylation site [posttranslational modification] 278197000417 tagatose 1,6-diphosphate aldolase; Reviewed; Region: PRK12399 278197000418 Firmicute fructose-1,6-bisphosphatase; Region: FBPase_2; pfam06874 278197000419 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 278197000420 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 278197000421 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 278197000422 oligomer interface [polypeptide binding]; other site 278197000423 Cl binding site [ion binding]; other site 278197000424 oxidoreductase; Provisional; Region: PRK07985 278197000425 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197000426 NAD(P) binding site [chemical binding]; other site 278197000427 active site 278197000428 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4876 278197000429 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 278197000430 MgtC family; Region: MgtC; pfam02308 278197000431 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 278197000432 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 278197000433 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 278197000434 putative active site [active] 278197000435 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 278197000436 N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130 278197000437 putative active site cavity [active] 278197000438 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 278197000439 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 278197000440 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 278197000441 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 278197000442 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 278197000443 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 278197000444 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533 278197000445 Putative glycosyl hydrolase of unknown function (DUF1680); Region: DUF1680; pfam07944 278197000446 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 278197000447 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197000448 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 278197000449 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278197000450 DNA-binding site [nucleotide binding]; DNA binding site 278197000451 Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541 278197000452 putative dimerization interface [polypeptide binding]; other site 278197000453 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 278197000454 putative ligand binding site [chemical binding]; other site 278197000455 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 278197000456 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278197000457 DNA-binding site [nucleotide binding]; DNA binding site 278197000458 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 278197000459 C4-dicarboxylate transporter [Energy production and conversion]; Region: DcuC; COG3069 278197000460 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 278197000461 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 278197000462 active site 278197000463 tetramer interface [polypeptide binding]; other site 278197000464 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 278197000465 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197000466 putative substrate translocation pore; other site 278197000467 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197000468 L-ribulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-RBK_like; cd07778 278197000469 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 278197000470 putative N- and C-terminal domain interface [polypeptide binding]; other site 278197000471 putative active site [active] 278197000472 MgATP binding site [chemical binding]; other site 278197000473 catalytic site [active] 278197000474 metal binding site [ion binding]; metal-binding site 278197000475 putative carbohydrate binding site [chemical binding]; other site 278197000476 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 278197000477 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 278197000478 intersubunit interface [polypeptide binding]; other site 278197000479 active site 278197000480 Zn2+ binding site [ion binding]; other site 278197000481 L-arabinose isomerase; Provisional; Region: PRK02929 278197000482 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 278197000483 hexamer (dimer of trimers) interface [polypeptide binding]; other site 278197000484 trimer interface [polypeptide binding]; other site 278197000485 substrate binding site [chemical binding]; other site 278197000486 Mn binding site [ion binding]; other site 278197000487 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 278197000488 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 278197000489 hexamer interface [polypeptide binding]; other site 278197000490 ligand binding site [chemical binding]; other site 278197000491 putative active site [active] 278197000492 NAD(P) binding site [chemical binding]; other site 278197000493 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 278197000494 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 278197000495 tetramer interface [polypeptide binding]; other site 278197000496 pyridoxal 5'-phosphate binding site [chemical binding]; other site 278197000497 catalytic residue [active] 278197000498 OPT oligopeptide transporter protein; Region: OPT; pfam03169 278197000499 putative oligopeptide transporter, OPT family; Region: TIGR00733 278197000500 Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126 278197000501 Peptidase family C69; Region: Peptidase_C69; pfam03577 278197000502 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 278197000503 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278197000504 DNA-binding site [nucleotide binding]; DNA binding site 278197000505 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 278197000506 active site 278197000507 phosphorylation site [posttranslational modification] 278197000508 PTS system sorbose-specific iic component; Region: EII-Sor; cl01506 278197000509 PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855 278197000510 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 278197000511 active pocket/dimerization site; other site 278197000512 active site 278197000513 phosphorylation site [posttranslational modification] 278197000514 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 278197000515 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278197000516 DNA-binding site [nucleotide binding]; DNA binding site 278197000517 UTRA domain; Region: UTRA; pfam07702 278197000518 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 278197000519 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278197000520 DNA-binding site [nucleotide binding]; DNA binding site 278197000521 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 278197000522 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 278197000523 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 278197000524 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 278197000525 Benzyl alcohol dehydrogenase; Region: benzyl_alcohol_DH; cd08278 278197000526 catalytic Zn binding site [ion binding]; other site 278197000527 NAD binding site [chemical binding]; other site 278197000528 structural Zn binding site [ion binding]; other site 278197000529 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 278197000530 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 278197000531 nucleotide binding site [chemical binding]; other site 278197000532 putative alpha-glucosidase; Provisional; Region: PRK10658 278197000533 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 278197000534 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 278197000535 active site 278197000536 homotrimer interface [polypeptide binding]; other site 278197000537 catalytic site [active] 278197000538 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 278197000539 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 278197000540 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197000541 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 278197000542 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 278197000543 nucleotide binding site [chemical binding]; other site 278197000544 xylose isomerase; Provisional; Region: PRK05474 278197000545 xylose isomerase; Region: xylose_isom_A; TIGR02630 278197000546 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 278197000547 N- and C-terminal domain interface [polypeptide binding]; other site 278197000548 D-xylulose kinase; Region: XylB; TIGR01312 278197000549 active site 278197000550 MgATP binding site [chemical binding]; other site 278197000551 catalytic site [active] 278197000552 metal binding site [ion binding]; metal-binding site 278197000553 xylulose binding site [chemical binding]; other site 278197000554 homodimer interface [polypeptide binding]; other site 278197000555 putrescine carbamoyltransferase; Provisional; Region: PRK02255 278197000556 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 278197000557 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 278197000558 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 278197000559 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 278197000560 agmatine deiminase; Provisional; Region: PRK13551 278197000561 agmatine deiminase; Region: agmatine_aguA; TIGR03380 278197000562 carbamate kinase; Reviewed; Region: PRK12686 278197000563 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 278197000564 putative substrate binding site [chemical binding]; other site 278197000565 nucleotide binding site [chemical binding]; other site 278197000566 nucleotide binding site [chemical binding]; other site 278197000567 homodimer interface [polypeptide binding]; other site 278197000568 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 278197000569 agmatine deiminase; Region: agmatine_aguA; TIGR03380 278197000570 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 278197000571 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 278197000572 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 278197000573 putative active site [active] 278197000574 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278197000575 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 278197000576 Walker A motif; other site 278197000577 ATP binding site [chemical binding]; other site 278197000578 Walker B motif; other site 278197000579 arginine finger; other site 278197000580 Transcriptional antiterminator [Transcription]; Region: COG3933 278197000581 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 278197000582 active pocket/dimerization site; other site 278197000583 active site 278197000584 phosphorylation site [posttranslational modification] 278197000585 PRD domain; Region: PRD; pfam00874 278197000586 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 278197000587 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 278197000588 Transcriptional regulators [Transcription]; Region: PurR; COG1609 278197000589 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 278197000590 DNA binding site [nucleotide binding] 278197000591 domain linker motif; other site 278197000592 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 278197000593 putative dimerization interface [polypeptide binding]; other site 278197000594 putative ligand binding site [chemical binding]; other site 278197000595 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 278197000596 active site 278197000597 catalytic residues [active] 278197000598 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 278197000599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197000600 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 278197000601 HPr interaction site; other site 278197000602 glycerol kinase (GK) interaction site [polypeptide binding]; other site 278197000603 active site 278197000604 phosphorylation site [posttranslational modification] 278197000605 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 278197000606 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 278197000607 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 278197000608 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 278197000609 galactokinase; Provisional; Region: PRK05322 278197000610 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 278197000611 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 278197000612 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 278197000613 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 278197000614 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 278197000615 NAD binding site [chemical binding]; other site 278197000616 homodimer interface [polypeptide binding]; other site 278197000617 active site 278197000618 substrate binding site [chemical binding]; other site 278197000619 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK05270 278197000620 Galactose-1-phosphate uridyl transferase, N-terminal domain; Region: GalP_UDP_transf; pfam01087 278197000621 Galactose-1-phosphate uridyl transferase, C-terminal domain; Region: GalP_UDP_tr_C; pfam02744 278197000622 fumarate hydratase; Reviewed; Region: fumC; PRK00485 278197000623 Class II fumarases; Region: Fumarase_classII; cd01362 278197000624 active site 278197000625 tetramer interface [polypeptide binding]; other site 278197000626 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 278197000627 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 278197000628 transmembrane helices; other site 278197000629 Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family [Posttranslational modification, protein turnover, chaperones]; Region: PpiB; COG0652 278197000630 active site 278197000631 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 278197000632 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 278197000633 active site 278197000634 nucleophile elbow; other site 278197000635 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197000636 putative substrate translocation pore; other site 278197000637 Predicted small molecule binding protein (contains 3H domain) [General function prediction only]; Region: COG1827 278197000638 HTH domain; Region: HTH_11; pfam08279 278197000639 3H domain; Region: 3H; pfam02829 278197000640 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 278197000641 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 278197000642 Ligand binding site; other site 278197000643 metal-binding site 278197000644 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 278197000645 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 278197000646 Ligand binding site; other site 278197000647 metal-binding site 278197000648 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 278197000649 tetramer (dimer of dimers) interface [polypeptide binding]; other site 278197000650 L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771 278197000651 NAD binding site [chemical binding]; other site 278197000652 dimer interface [polypeptide binding]; other site 278197000653 substrate binding site [chemical binding]; other site 278197000654 Protein of unknown function (DUF1093); Region: DUF1093; cl02185 278197000655 Uncharacterized conserved protein [Function unknown]; Region: COG1434 278197000656 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 278197000657 putative active site [active] 278197000658 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 278197000659 active site 278197000660 catalytic residues [active] 278197000661 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 278197000662 EamA-like transporter family; Region: EamA; cl17759 278197000663 EamA-like transporter family; Region: EamA; pfam00892 278197000664 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 278197000665 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 278197000666 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 278197000667 Domain of unknown function (DUF1975); Region: DUF1975; pfam09318 278197000668 This family is most closely related to the GT1 family of glycosyltransferases and is named after gtfA in Streptococcus gordonii, where it plays a role in the O-linked glycosylation of GspB, a cell surface glycoprotein involved in platelet binding. In...; Region: GT1_gtfA_like; cd04949 278197000669 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 278197000670 Nitroreductase-like family 4. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_4; cd02140 278197000671 dimer interface [polypeptide binding]; other site 278197000672 FMN binding site [chemical binding]; other site 278197000673 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 278197000674 dimer interface [polypeptide binding]; other site 278197000675 substrate binding site [chemical binding]; other site 278197000676 ATP binding site [chemical binding]; other site 278197000677 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cd00741 278197000678 nucleophilic elbow; other site 278197000679 catalytic triad; other site 278197000680 Uncharacterized conserved protein [Function unknown]; Region: COG3589 278197000681 Bacterial protein of unknown function (DUF871); Region: DUF871; pfam05913 278197000682 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 278197000683 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 278197000684 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 278197000685 NADH(P)-binding; Region: NAD_binding_10; pfam13460 278197000686 putative NAD(P) binding site [chemical binding]; other site 278197000687 dipeptidase PepV; Reviewed; Region: PRK07318 278197000688 M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888 278197000689 active site 278197000690 metal binding site [ion binding]; metal-binding site 278197000691 tyrosyl-tRNA synthetase; Provisional; Region: PRK13354 278197000692 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 278197000693 active site 278197000694 HIGH motif; other site 278197000695 dimer interface [polypeptide binding]; other site 278197000696 KMSKS motif; other site 278197000697 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 278197000698 RNA binding surface [nucleotide binding]; other site 278197000699 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 278197000700 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 278197000701 Na binding site [ion binding]; other site 278197000702 cytosine deaminase; Provisional; Region: PRK09230 278197000703 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 278197000704 active site 278197000705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278197000706 ABC-ATPase subunit interface; other site 278197000707 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 278197000708 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 278197000709 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 278197000710 Walker A/P-loop; other site 278197000711 ATP binding site [chemical binding]; other site 278197000712 Q-loop/lid; other site 278197000713 ABC transporter signature motif; other site 278197000714 Walker B; other site 278197000715 D-loop; other site 278197000716 H-loop/switch region; other site 278197000717 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 278197000718 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 278197000719 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 278197000720 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 278197000721 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 278197000722 pyruvate carboxylase; Reviewed; Region: PRK12999 278197000723 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 278197000724 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 278197000725 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 278197000726 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 278197000727 active site 278197000728 catalytic residues [active] 278197000729 metal binding site [ion binding]; metal-binding site 278197000730 homodimer binding site [polypeptide binding]; other site 278197000731 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 278197000732 carboxyltransferase (CT) interaction site; other site 278197000733 biotinylation site [posttranslational modification]; other site 278197000734 aspartate aminotransferase; Provisional; Region: PRK05764 278197000735 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 278197000736 pyridoxal 5'-phosphate binding site [chemical binding]; other site 278197000737 homodimer interface [polypeptide binding]; other site 278197000738 catalytic residue [active] 278197000739 Protein of unknown function (DUF554); Region: DUF554; pfam04474 278197000740 Transcriptional regulator [Transcription]; Region: LysR; COG0583 278197000741 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 278197000742 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 278197000743 dimerization interface [polypeptide binding]; other site 278197000744 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 278197000745 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 278197000746 Flavoprotein; Region: Flavoprotein; pfam02441 278197000747 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 278197000748 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 278197000749 putative NAD(P) binding site [chemical binding]; other site 278197000750 Protein of unknown function, DUF606; Region: DUF606; pfam04657 278197000751 Protein of unknown function, DUF606; Region: DUF606; pfam04657 278197000752 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 278197000753 Part of AAA domain; Region: AAA_19; pfam13245 278197000754 Family description; Region: UvrD_C_2; pfam13538 278197000755 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 278197000756 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 278197000757 active site 278197000758 HIGH motif; other site 278197000759 dimer interface [polypeptide binding]; other site 278197000760 KMSKS motif; other site 278197000761 exopolyphosphatase; Region: exo_poly_only; TIGR03706 278197000762 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 278197000763 Class II hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase (HMGR); Region: HMG-CoA_reductase_classII; cd00644 278197000764 homodimer interface [polypeptide binding]; other site 278197000765 catalytic residues [active] 278197000766 NAD binding site [chemical binding]; other site 278197000767 substrate binding pocket [chemical binding]; other site 278197000768 flexible flap; other site 278197000769 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 278197000770 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 278197000771 non-specific DNA binding site [nucleotide binding]; other site 278197000772 salt bridge; other site 278197000773 sequence-specific DNA binding site [nucleotide binding]; other site 278197000774 PspC domain; Region: PspC; pfam04024 278197000775 Protein of unknown function DUF72; Region: DUF72; pfam01904 278197000776 methionyl-tRNA synthetase; Reviewed; Region: PRK12267 278197000777 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 278197000778 HIGH motif; other site 278197000779 active site 278197000780 KMSKS motif; other site 278197000781 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 278197000782 tRNA binding surface [nucleotide binding]; other site 278197000783 anticodon binding site; other site 278197000784 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 278197000785 dimer interface [polypeptide binding]; other site 278197000786 putative tRNA-binding site [nucleotide binding]; other site 278197000787 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 278197000788 active site 278197000789 ribonuclease M5; Region: 5S_RNA_mat_M5; TIGR00334 278197000790 TOPRIM_ RNase M5_like: The topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain found in Ribonuclease M5: (RNase M5) and other small primase-like proteins from bacteria and archaea. RNase M5 catalyzes the maturation of 5S rRNA in low...; Region: TOPRIM_RNase_M5_like; cd01027 278197000791 putative active site [active] 278197000792 putative metal binding site [ion binding]; other site 278197000793 Domain of unknown function (DUF4093); Region: DUF4093; pfam13331 278197000794 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 278197000795 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 278197000796 S-adenosylmethionine binding site [chemical binding]; other site 278197000797 Protein of unknown function (DUF1021); Region: DUF1021; pfam06257 278197000798 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128 278197000799 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 278197000800 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 278197000801 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278197000802 Transcriptional regulator C-terminal region; Region: TetR_C_8; pfam14278 278197000803 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 278197000804 Ligand Binding Site [chemical binding]; other site 278197000805 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 278197000806 Ligand Binding Site [chemical binding]; other site 278197000807 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197000808 Major Facilitator Superfamily; Region: MFS_1; pfam07690 278197000809 putative substrate translocation pore; other site 278197000810 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197000811 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 278197000812 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 278197000813 dimer interface [polypeptide binding]; other site 278197000814 active site 278197000815 metal binding site [ion binding]; metal-binding site 278197000816 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101 278197000817 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 278197000818 Walker A/P-loop; other site 278197000819 ATP binding site [chemical binding]; other site 278197000820 Q-loop/lid; other site 278197000821 ABC transporter signature motif; other site 278197000822 Walker B; other site 278197000823 D-loop; other site 278197000824 H-loop/switch region; other site 278197000825 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574 278197000826 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 278197000827 TM-ABC transporter signature motif; other site 278197000828 Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325 278197000829 zinc binding site [ion binding]; other site 278197000830 putative ligand binding site [chemical binding]; other site 278197000831 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 278197000832 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278197000833 DNA-binding site [nucleotide binding]; DNA binding site 278197000834 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 278197000835 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 278197000836 active site 278197000837 P-loop; other site 278197000838 phosphorylation site [posttranslational modification] 278197000839 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 278197000840 active site 278197000841 methionine cluster; other site 278197000842 phosphorylation site [posttranslational modification] 278197000843 metal binding site [ion binding]; metal-binding site 278197000844 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 278197000845 beta-galactosidase; Region: BGL; TIGR03356 278197000846 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 278197000847 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 278197000848 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 278197000849 putative active site [active] 278197000850 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 278197000851 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 278197000852 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 278197000853 acetoin reductase; Validated; Region: PRK08643 278197000854 meso-2,3-butanediol dehydrogenase-like, classical (c) SDRs; Region: meso-BDH-like_SDR_c; cd05366 278197000855 NAD binding site [chemical binding]; other site 278197000856 homotetramer interface [polypeptide binding]; other site 278197000857 homodimer interface [polypeptide binding]; other site 278197000858 active site 278197000859 substrate binding site [chemical binding]; other site 278197000860 Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033 278197000861 putative uracil binding site [chemical binding]; other site 278197000862 putative active site [active] 278197000863 Acetyltransferase (GNAT) domain; Region: Acetyltransf_9; pfam13527 278197000864 Sterol carrier protein domain; Region: SCP2_2; pfam13530 278197000865 Metal binding protein TroA_b. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: TroA_b; cd01020 278197000866 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 278197000867 metal binding site [ion binding]; metal-binding site 278197000868 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 278197000869 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 278197000870 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 278197000871 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 278197000872 ABC-ATPase subunit interface; other site 278197000873 dimer interface [polypeptide binding]; other site 278197000874 putative PBP binding regions; other site 278197000875 pur operon repressor; Provisional; Region: PRK09213 278197000876 Bacterial purine repressor, N-terminal; Region: PuR_N; pfam09182 278197000877 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 278197000878 active site 278197000879 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354 278197000880 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 278197000881 Substrate binding site; other site 278197000882 Mg++ binding site; other site 278197000883 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 278197000884 active site 278197000885 substrate binding site [chemical binding]; other site 278197000886 CoA binding site [chemical binding]; other site 278197000887 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 278197000888 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 278197000889 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 278197000890 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 278197000891 active site 278197000892 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 278197000893 Double zinc ribbon; Region: DZR; pfam12773 278197000894 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 278197000895 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cl00200 278197000896 amphipathic channel; other site 278197000897 Asn-Pro-Ala signature motifs; other site 278197000898 Ion transport protein; Region: Ion_trans; pfam00520 278197000899 Ion channel; Region: Ion_trans_2; pfam07885 278197000900 Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964 278197000901 active site 278197000902 homotetramer interface [polypeptide binding]; other site 278197000903 homodimer interface [polypeptide binding]; other site 278197000904 Predicted metalloendopeptidase [Posttranslational modification, protein turnover, chaperones]; Region: PepO; COG3590 278197000905 Peptidase family M13 includes neprilysin, endothelin-converting enzyme I; Region: M13; cd08662 278197000906 active site 278197000907 Zn binding site [ion binding]; other site 278197000908 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 278197000909 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 278197000910 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 278197000911 RNA/DNA hybrid binding site [nucleotide binding]; other site 278197000912 active site 278197000913 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 278197000914 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 278197000915 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 278197000916 LysR transcriptional regulator; Provisional; Region: rbcR; CHL00180 278197000917 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 278197000918 dimerization interface [polypeptide binding]; other site 278197000919 Predicted membrane protein [Function unknown]; Region: COG2855 278197000920 Membrane transport protein; Region: Mem_trans; pfam03547 278197000921 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 278197000922 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 278197000923 active site 278197000924 motif I; other site 278197000925 motif II; other site 278197000926 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 278197000927 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 278197000928 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 278197000929 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 278197000930 dihydroorotase; Validated; Region: pyrC; PRK09357 278197000931 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 278197000932 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 278197000933 active site 278197000934 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 278197000935 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 278197000936 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 278197000937 catalytic site [active] 278197000938 subunit interface [polypeptide binding]; other site 278197000939 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 278197000940 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 278197000941 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 278197000942 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 278197000943 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 278197000944 ATP-grasp domain; Region: ATP-grasp_4; cl17255 278197000945 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 278197000946 IMP binding site; other site 278197000947 dimer interface [polypeptide binding]; other site 278197000948 interdomain contacts; other site 278197000949 partial ornithine binding site; other site 278197000950 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 278197000951 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 278197000952 heterodimer interface [polypeptide binding]; other site 278197000953 active site 278197000954 FMN binding site [chemical binding]; other site 278197000955 homodimer interface [polypeptide binding]; other site 278197000956 substrate binding site [chemical binding]; other site 278197000957 L-aspartate oxidase; Provisional; Region: PRK06175 278197000958 flavocytochrome c; Region: flavo_cyto_c; TIGR01813 278197000959 L-aspartate oxidase; Provisional; Region: PRK06175 278197000960 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 278197000961 Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096 278197000962 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 278197000963 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 278197000964 DXD motif; other site 278197000965 Bacterial cellulose synthase subunit; Region: BcsB; cl15851 278197000966 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 278197000967 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 278197000968 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 278197000969 putative metal binding site [ion binding]; other site 278197000970 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278197000971 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 278197000972 Predicted drug exporters of the RND superfamily [General function prediction only]; Region: COG2409 278197000973 biliverdin IX beta reductase (BVR-B, aka flavin reductase)-like proteins; atypical (a) SDRs; Region: BVR-B_like_SDR_a; cd05244 278197000974 NADH(P)-binding; Region: NAD_binding_10; pfam13460 278197000975 NAD binding site [chemical binding]; other site 278197000976 substrate binding site [chemical binding]; other site 278197000977 putative active site [active] 278197000978 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 278197000979 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 278197000980 Walker A/P-loop; other site 278197000981 ATP binding site [chemical binding]; other site 278197000982 Q-loop/lid; other site 278197000983 ABC transporter signature motif; other site 278197000984 Walker B; other site 278197000985 D-loop; other site 278197000986 H-loop/switch region; other site 278197000987 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 278197000988 NMT1/THI5 like; Region: NMT1; pfam09084 278197000989 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 278197000990 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278197000991 dimer interface [polypeptide binding]; other site 278197000992 conserved gate region; other site 278197000993 putative PBP binding loops; other site 278197000994 ABC-ATPase subunit interface; other site 278197000995 Domain of unknown function DUF77; Region: DUF77; pfam01910 278197000996 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 278197000997 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 278197000998 active site 278197000999 trimer interface [polypeptide binding]; other site 278197001000 allosteric site; other site 278197001001 active site lid [active] 278197001002 hexamer (dimer of trimers) interface [polypeptide binding]; other site 278197001003 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 278197001004 propionate/acetate kinase; Provisional; Region: PRK12379 278197001005 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 278197001006 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 278197001007 metal binding site 2 [ion binding]; metal-binding site 278197001008 putative DNA binding helix; other site 278197001009 metal binding site 1 [ion binding]; metal-binding site 278197001010 dimer interface [polypeptide binding]; other site 278197001011 structural Zn2+ binding site [ion binding]; other site 278197001012 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 278197001013 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 278197001014 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 278197001015 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 278197001016 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 278197001017 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 278197001018 Tyrosine phosphatase family; Region: Y_phosphatase3; pfam13350 278197001019 Tyrosine phosphatase family C-terminal region; Region: Y_phosphatase3C; pfam13348 278197001020 flavoprotein NrdI; Provisional; Region: PRK02551 278197001021 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278197001022 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 278197001023 active site 278197001024 motif I; other site 278197001025 motif II; other site 278197001026 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278197001027 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 278197001028 Domain of unknown function DUF21; Region: DUF21; pfam01595 278197001029 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 278197001030 Transporter associated domain; Region: CorC_HlyC; smart01091 278197001031 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 278197001032 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 278197001033 active site 278197001034 catalytic tetrad [active] 278197001035 GyrI-like small molecule binding domain; Region: GyrI-like; cl01368 278197001036 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 278197001037 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 278197001038 putative deacylase active site [active] 278197001039 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 278197001040 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278197001041 DNA-binding site [nucleotide binding]; DNA binding site 278197001042 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 278197001043 putative phosphoketolase; Provisional; Region: PRK05261 278197001044 Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011 278197001045 TPP-binding site; other site 278197001046 XFP C-terminal domain; Region: XFP_C; pfam09363 278197001047 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 278197001048 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 278197001049 active site 278197001050 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 278197001051 Ligand Binding Site [chemical binding]; other site 278197001052 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 278197001053 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 278197001054 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 278197001055 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 278197001056 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 278197001057 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 278197001058 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 278197001059 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 278197001060 non-specific DNA binding site [nucleotide binding]; other site 278197001061 salt bridge; other site 278197001062 sequence-specific DNA binding site [nucleotide binding]; other site 278197001063 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 278197001064 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 278197001065 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 278197001066 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 278197001067 active site 278197001068 Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492 278197001069 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 278197001070 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 278197001071 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 278197001072 Sulfatase; Region: Sulfatase; pfam00884 278197001073 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 278197001074 Coenzyme A binding pocket [chemical binding]; other site 278197001075 YibE/F-like protein; Region: YibE_F; pfam07907 278197001076 YibE/F-like protein; Region: YibE_F; pfam07907 278197001077 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 278197001078 uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827 278197001079 Cl binding site [ion binding]; other site 278197001080 oligomer interface [polypeptide binding]; other site 278197001081 integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716 278197001082 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 278197001083 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 278197001084 catalytic residues [active] 278197001085 EDD domain protein, DegV family; Region: DegV; TIGR00762 278197001086 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 278197001087 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 278197001088 active site 278197001089 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253 278197001090 dimer interface [polypeptide binding]; other site 278197001091 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 278197001092 metal binding site [ion binding]; metal-binding site 278197001093 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 278197001094 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 278197001095 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 278197001096 Walker A/P-loop; other site 278197001097 ATP binding site [chemical binding]; other site 278197001098 Q-loop/lid; other site 278197001099 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 278197001100 ABC transporter signature motif; other site 278197001101 Walker B; other site 278197001102 D-loop; other site 278197001103 ABC transporter; Region: ABC_tran_2; pfam12848 278197001104 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 278197001105 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 278197001106 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 278197001107 active site 278197001108 catalytic tetrad [active] 278197001109 proline-specific peptidase, Bacillus coagulans-type subfamily; Region: pro_imino_pep_2; TIGR01250 278197001110 TAP-like protein; Region: Abhydrolase_4; pfam08386 278197001111 x-prolyl-dipeptidyl aminopeptidase; Provisional; Region: PRK05371 278197001112 X-Prolyl dipeptidyl aminopeptidase PepX, N-terminal; Region: PepX_N; smart00940 278197001113 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; pfam08530 278197001114 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 278197001115 amino acid transporter; Region: 2A0306; TIGR00909 278197001116 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 278197001117 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_human_like; cd03428 278197001118 active site 278197001119 Ap4A binding cleft/pocket [chemical binding]; other site 278197001120 P4 phosphate binding site; other site 278197001121 nudix motif; other site 278197001122 putative P2/P3 phosphate binding site [ion binding]; other site 278197001123 Guanylate kinase; Region: Guanylate_kin; pfam00625 278197001124 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 278197001125 active site 278197001126 ferric uptake regulator; Provisional; Region: fur; PRK09462 278197001127 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 278197001128 metal binding site 2 [ion binding]; metal-binding site 278197001129 putative DNA binding helix; other site 278197001130 metal binding site 1 [ion binding]; metal-binding site 278197001131 dimer interface [polypeptide binding]; other site 278197001132 structural Zn2+ binding site [ion binding]; other site 278197001133 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 278197001134 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 278197001135 Walker A/P-loop; other site 278197001136 ATP binding site [chemical binding]; other site 278197001137 Q-loop/lid; other site 278197001138 ABC transporter signature motif; other site 278197001139 Walker B; other site 278197001140 D-loop; other site 278197001141 H-loop/switch region; other site 278197001142 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 278197001143 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 278197001144 substrate binding pocket [chemical binding]; other site 278197001145 membrane-bound complex binding site; other site 278197001146 hinge residues; other site 278197001147 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 278197001148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278197001149 dimer interface [polypeptide binding]; other site 278197001150 conserved gate region; other site 278197001151 putative PBP binding loops; other site 278197001152 ABC-ATPase subunit interface; other site 278197001153 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278197001154 dimer interface [polypeptide binding]; other site 278197001155 conserved gate region; other site 278197001156 putative PBP binding loops; other site 278197001157 ABC-ATPase subunit interface; other site 278197001158 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 278197001159 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 278197001160 Helix-Turn-Helix DNA binding domain of BmrR-like transcription regulators; Region: HTH_BmrR-like; cd04768 278197001161 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 278197001162 DNA binding residues [nucleotide binding] 278197001163 drug binding residues [chemical binding]; other site 278197001164 dimer interface [polypeptide binding]; other site 278197001165 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 278197001166 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 278197001167 HflX GTPase family; Region: HflX; cd01878 278197001168 G1 box; other site 278197001169 GTP/Mg2+ binding site [chemical binding]; other site 278197001170 Switch I region; other site 278197001171 G2 box; other site 278197001172 G3 box; other site 278197001173 Switch II region; other site 278197001174 G4 box; other site 278197001175 G5 box; other site 278197001176 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 278197001177 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 278197001178 peptide binding site [polypeptide binding]; other site 278197001179 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 278197001180 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278197001181 dimer interface [polypeptide binding]; other site 278197001182 conserved gate region; other site 278197001183 putative PBP binding loops; other site 278197001184 ABC-ATPase subunit interface; other site 278197001185 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 278197001186 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 278197001187 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278197001188 dimer interface [polypeptide binding]; other site 278197001189 conserved gate region; other site 278197001190 putative PBP binding loops; other site 278197001191 ABC-ATPase subunit interface; other site 278197001192 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 278197001193 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 278197001194 Walker A/P-loop; other site 278197001195 ATP binding site [chemical binding]; other site 278197001196 Q-loop/lid; other site 278197001197 ABC transporter signature motif; other site 278197001198 Walker B; other site 278197001199 D-loop; other site 278197001200 H-loop/switch region; other site 278197001201 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 278197001202 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 278197001203 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 278197001204 Walker A/P-loop; other site 278197001205 ATP binding site [chemical binding]; other site 278197001206 Q-loop/lid; other site 278197001207 ABC transporter signature motif; other site 278197001208 Walker B; other site 278197001209 D-loop; other site 278197001210 H-loop/switch region; other site 278197001211 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 278197001212 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 278197001213 catalytic core [active] 278197001214 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 278197001215 Amino acid permease; Region: AA_permease_2; pfam13520 278197001216 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 278197001217 catalytic core [active] 278197001218 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 278197001219 Superfamily I DNA and RNA helicases [General function prediction only]; Region: COG3973 278197001220 Part of AAA domain; Region: AAA_19; pfam13245 278197001221 Family description; Region: UvrD_C_2; pfam13538 278197001222 acetolactate synthase; Reviewed; Region: PRK08617 278197001223 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 278197001224 PYR/PP interface [polypeptide binding]; other site 278197001225 dimer interface [polypeptide binding]; other site 278197001226 TPP binding site [chemical binding]; other site 278197001227 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 278197001228 Thiamine pyrophosphate (TPP) family, Acetolactate synthase (ALS) subfamily, TPP-binding module; composed of proteins similar to Klebsiella pneumoniae ALS, a catabolic enzyme required for butanediol fermentation. ALS catalyzes the conversion of 2...; Region: TPP_ALS; cd02010 278197001229 TPP-binding site [chemical binding]; other site 278197001230 dimer interface [polypeptide binding]; other site 278197001231 Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306 278197001232 pantothenate kinase; Provisional; Region: PRK05439 278197001233 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 278197001234 ATP-binding site [chemical binding]; other site 278197001235 CoA-binding site [chemical binding]; other site 278197001236 Mg2+-binding site [ion binding]; other site 278197001237 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 278197001238 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 278197001239 ligand binding site [chemical binding]; other site 278197001240 flexible hinge region; other site 278197001241 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 278197001242 putative switch regulator; other site 278197001243 non-specific DNA interactions [nucleotide binding]; other site 278197001244 DNA binding site [nucleotide binding] 278197001245 sequence specific DNA binding site [nucleotide binding]; other site 278197001246 putative cAMP binding site [chemical binding]; other site 278197001247 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 278197001248 metal-binding site [ion binding] 278197001249 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 278197001250 dimerization interface [polypeptide binding]; other site 278197001251 DPS ferroxidase diiron center [ion binding]; other site 278197001252 ion pore; other site 278197001253 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 278197001254 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 278197001255 Soluble P-type ATPase [General function prediction only]; Region: COG4087 278197001256 GMP synthase; Reviewed; Region: guaA; PRK00074 278197001257 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 278197001258 AMP/PPi binding site [chemical binding]; other site 278197001259 candidate oxyanion hole; other site 278197001260 catalytic triad [active] 278197001261 potential glutamine specificity residues [chemical binding]; other site 278197001262 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 278197001263 ATP Binding subdomain [chemical binding]; other site 278197001264 Dimerization subdomain; other site 278197001265 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 278197001266 non-specific DNA binding site [nucleotide binding]; other site 278197001267 salt bridge; other site 278197001268 sequence-specific DNA binding site [nucleotide binding]; other site 278197001269 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197001270 Major Facilitator Superfamily; Region: MFS_1; pfam07690 278197001271 putative substrate translocation pore; other site 278197001272 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197001273 Peptidase family M1; Region: Peptidase_M1; pfam01433 278197001274 Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ); Region: M1_APN_2; cd09601 278197001275 Zn binding site [ion binding]; other site 278197001276 Domain of unknown function (DUF3358); Region: DUF3358; pfam11838 278197001277 CAAX protease self-immunity; Region: Abi; pfam02517 278197001278 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 278197001279 oligomerisation interface [polypeptide binding]; other site 278197001280 mobile loop; other site 278197001281 roof hairpin; other site 278197001282 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 278197001283 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 278197001284 ring oligomerisation interface [polypeptide binding]; other site 278197001285 ATP/Mg binding site [chemical binding]; other site 278197001286 stacking interactions; other site 278197001287 hinge regions; other site 278197001288 Amino acid permease; Region: AA_permease_2; pfam13520 278197001289 K+ potassium transporter; Region: K_trans; cl15781 278197001290 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 278197001291 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 278197001292 Mg++ binding site [ion binding]; other site 278197001293 putative catalytic motif [active] 278197001294 substrate binding site [chemical binding]; other site 278197001295 Uncharacterized conserved protein [Function unknown]; Region: COG1739 278197001296 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 278197001297 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 278197001298 Superfamily II DNA/RNA helicase required for DNA uptake (late competence protein) [DNA replication, recombination, and repair]; Region: comFA; COG4098 278197001299 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 278197001300 ATP binding site [chemical binding]; other site 278197001301 putative Mg++ binding site [ion binding]; other site 278197001302 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 278197001303 nucleotide binding region [chemical binding]; other site 278197001304 ATP-binding site [chemical binding]; other site 278197001305 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 278197001306 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 278197001307 active site 278197001308 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 278197001309 30S subunit binding site; other site 278197001310 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 278197001311 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 278197001312 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351 278197001313 nucleotide binding region [chemical binding]; other site 278197001314 ATP-binding site [chemical binding]; other site 278197001315 peptide chain release factor 2; Validated; Region: prfB; PRK00578 278197001316 This domain is found in peptide chain release factors; Region: PCRF; smart00937 278197001317 RF-1 domain; Region: RF-1; pfam00472 278197001318 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 278197001319 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278197001320 active site 278197001321 phosphorylation site [posttranslational modification] 278197001322 intermolecular recognition site; other site 278197001323 dimerization interface [polypeptide binding]; other site 278197001324 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 278197001325 DNA binding site [nucleotide binding] 278197001326 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 278197001327 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 278197001328 dimer interface [polypeptide binding]; other site 278197001329 phosphorylation site [posttranslational modification] 278197001330 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278197001331 ATP binding site [chemical binding]; other site 278197001332 Mg2+ binding site [ion binding]; other site 278197001333 G-X-G motif; other site 278197001334 PBP superfamily domain; Region: PBP_like_2; cl17296 278197001335 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 278197001336 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 278197001337 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278197001338 dimer interface [polypeptide binding]; other site 278197001339 conserved gate region; other site 278197001340 putative PBP binding loops; other site 278197001341 ABC-ATPase subunit interface; other site 278197001342 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 278197001343 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278197001344 dimer interface [polypeptide binding]; other site 278197001345 conserved gate region; other site 278197001346 putative PBP binding loops; other site 278197001347 ABC-ATPase subunit interface; other site 278197001348 phosphate transporter ATP-binding protein; Provisional; Region: PRK14237 278197001349 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 278197001350 Walker A/P-loop; other site 278197001351 ATP binding site [chemical binding]; other site 278197001352 Q-loop/lid; other site 278197001353 ABC transporter signature motif; other site 278197001354 Walker B; other site 278197001355 D-loop; other site 278197001356 H-loop/switch region; other site 278197001357 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 278197001358 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 278197001359 Walker A/P-loop; other site 278197001360 ATP binding site [chemical binding]; other site 278197001361 Q-loop/lid; other site 278197001362 ABC transporter signature motif; other site 278197001363 Walker B; other site 278197001364 D-loop; other site 278197001365 H-loop/switch region; other site 278197001366 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 278197001367 PhoU domain; Region: PhoU; pfam01895 278197001368 PhoU domain; Region: PhoU; pfam01895 278197001369 PspC domain; Region: PspC; pfam04024 278197001370 Predicted membrane protein [Function unknown]; Region: COG1950 278197001371 HPr kinase/phosphorylase; Provisional; Region: PRK05428 278197001372 HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603 278197001373 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 278197001374 Hpr binding site; other site 278197001375 active site 278197001376 homohexamer subunit interaction site [polypeptide binding]; other site 278197001377 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437 278197001378 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 278197001379 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 278197001380 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 278197001381 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 278197001382 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 278197001383 active site 278197001384 tetramer interface; other site 278197001385 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 278197001386 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 278197001387 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 278197001388 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 278197001389 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 278197001390 active site 278197001391 substrate binding site [chemical binding]; other site 278197001392 metal binding site [ion binding]; metal-binding site 278197001393 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 278197001394 Zn2+ binding site [ion binding]; other site 278197001395 Mg2+ binding site [ion binding]; other site 278197001396 excinuclease ABC subunit B; Provisional; Region: PRK05298 278197001397 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 278197001398 ATP binding site [chemical binding]; other site 278197001399 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 278197001400 nucleotide binding region [chemical binding]; other site 278197001401 ATP-binding site [chemical binding]; other site 278197001402 Ultra-violet resistance protein B; Region: UvrB; pfam12344 278197001403 UvrB/uvrC motif; Region: UVR; pfam02151 278197001404 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 278197001405 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 278197001406 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 278197001407 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 278197001408 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 278197001409 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 278197001410 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 278197001411 putative substrate binding pocket [chemical binding]; other site 278197001412 dimer interface [polypeptide binding]; other site 278197001413 phosphate binding site [ion binding]; other site 278197001414 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481 278197001415 Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298 278197001416 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 278197001417 amidase catalytic site [active] 278197001418 Zn binding residues [ion binding]; other site 278197001419 substrate binding site [chemical binding]; other site 278197001420 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832 278197001421 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 278197001422 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 278197001423 oligomer interface [polypeptide binding]; other site 278197001424 active site residues [active] 278197001425 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 278197001426 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 278197001427 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 278197001428 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 278197001429 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 278197001430 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 278197001431 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 278197001432 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 278197001433 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 278197001434 Phosphoglycerate kinase; Region: PGK; pfam00162 278197001435 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 278197001436 substrate binding site [chemical binding]; other site 278197001437 hinge regions; other site 278197001438 ADP binding site [chemical binding]; other site 278197001439 catalytic site [active] 278197001440 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 278197001441 triosephosphate isomerase; Provisional; Region: PRK14567 278197001442 substrate binding site [chemical binding]; other site 278197001443 dimer interface [polypeptide binding]; other site 278197001444 catalytic triad [active] 278197001445 enolase; Provisional; Region: eno; PRK00077 278197001446 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 278197001447 dimer interface [polypeptide binding]; other site 278197001448 metal binding site [ion binding]; metal-binding site 278197001449 substrate binding pocket [chemical binding]; other site 278197001450 Preprotein translocase subunit SecG [Intracellular trafficking and secretion]; Region: SecG; COG1314 278197001451 ribonuclease R; Region: RNase_R; TIGR02063 278197001452 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 278197001453 RNB domain; Region: RNB; pfam00773 278197001454 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 278197001455 RNA binding site [nucleotide binding]; other site 278197001456 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 278197001457 SmpB-tmRNA interface; other site 278197001458 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 278197001459 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 278197001460 Coenzyme A binding pocket [chemical binding]; other site 278197001461 Tubby C 2; Region: Tub_2; cl02043 278197001462 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278197001463 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 278197001464 active site 278197001465 motif I; other site 278197001466 motif II; other site 278197001467 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 278197001468 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 278197001469 ligand binding site [chemical binding]; other site 278197001470 active site 278197001471 UGI interface [polypeptide binding]; other site 278197001472 catalytic site [active] 278197001473 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 278197001474 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 278197001475 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 278197001476 Coenzyme A binding pocket [chemical binding]; other site 278197001477 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 278197001478 an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130 278197001479 active site 278197001480 catalytic site [active] 278197001481 substrate binding site [chemical binding]; other site 278197001482 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 278197001483 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 278197001484 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 278197001485 FAD binding domain; Region: FAD_binding_4; pfam01565 278197001486 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 278197001487 Uncharacterized conserved protein [Function unknown]; Region: COG1624 278197001488 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 278197001489 YbbR-like protein; Region: YbbR; pfam07949 278197001490 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316 278197001491 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 278197001492 active site 278197001493 substrate binding site [chemical binding]; other site 278197001494 metal binding site [ion binding]; metal-binding site 278197001495 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 278197001496 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 278197001497 glutaminase active site [active] 278197001498 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 278197001499 dimer interface [polypeptide binding]; other site 278197001500 active site 278197001501 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 278197001502 dimer interface [polypeptide binding]; other site 278197001503 active site 278197001504 HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB 278197001505 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278197001506 motif II; other site 278197001507 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 278197001508 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 278197001509 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 278197001510 Class III ribonucleotide reductase; Region: RNR_III; cd01675 278197001511 effector binding site; other site 278197001512 active site 278197001513 Zn binding site [ion binding]; other site 278197001514 glycine loop; other site 278197001515 4Fe-4S single cluster domain; Region: Fer4_12; pfam13353 278197001516 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 278197001517 FeS/SAM binding site; other site 278197001518 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 278197001519 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 278197001520 Walker A/P-loop; other site 278197001521 ATP binding site [chemical binding]; other site 278197001522 Q-loop/lid; other site 278197001523 ABC transporter signature motif; other site 278197001524 Walker B; other site 278197001525 D-loop; other site 278197001526 H-loop/switch region; other site 278197001527 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 278197001528 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 278197001529 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 278197001530 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 278197001531 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 278197001532 catalytic residue [active] 278197001533 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 278197001534 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 278197001535 trimerization site [polypeptide binding]; other site 278197001536 active site 278197001537 FeS assembly protein SufB; Region: sufB; TIGR01980 278197001538 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 278197001539 Phenolic acid decarboxylase (PAD); Region: PA_decarbox; pfam05870 278197001540 Predicted transcriptional regulators [Transcription]; Region: COG1695 278197001541 Transcriptional regulator PadR-like family; Region: PadR; cl17335 278197001542 Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400 278197001543 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 278197001544 Domain of unknown function DUF21; Region: DUF21; pfam01595 278197001545 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 278197001546 substrate binding site [chemical binding]; other site 278197001547 THF binding site; other site 278197001548 zinc-binding site [ion binding]; other site 278197001549 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 278197001550 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 278197001551 catalytic residues [active] 278197001552 catalytic nucleophile [active] 278197001553 Presynaptic Site I dimer interface [polypeptide binding]; other site 278197001554 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 278197001555 Synaptic Flat tetramer interface [polypeptide binding]; other site 278197001556 Synaptic Site I dimer interface [polypeptide binding]; other site 278197001557 DNA binding site [nucleotide binding] 278197001558 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 278197001559 Helix-turn-helix domain; Region: HTH_38; pfam13936 278197001560 Integrase core domain; Region: rve; pfam00665 278197001561 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 278197001562 multicopper oxidase; Provisional; Region: PRK10965 278197001563 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 278197001564 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 278197001565 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197001566 Major Facilitator Superfamily; Region: MFS_1; pfam07690 278197001567 putative substrate translocation pore; other site 278197001568 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 278197001569 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 278197001570 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 278197001571 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 278197001572 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 278197001573 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 278197001574 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 278197001575 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 278197001576 HPr interaction site; other site 278197001577 glycerol kinase (GK) interaction site [polypeptide binding]; other site 278197001578 active site 278197001579 phosphorylation site [posttranslational modification] 278197001580 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 278197001581 Melibiase; Region: Melibiase; pfam02065 278197001582 Sugar efflux transporter for intercellular exchange; Region: MtN3_slv; pfam03083 278197001583 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 278197001584 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 278197001585 nucleotide binding site [chemical binding]; other site 278197001586 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 278197001587 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 278197001588 Melibiase; Region: Melibiase; pfam02065 278197001589 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 278197001590 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 278197001591 active site turn [active] 278197001592 phosphorylation site [posttranslational modification] 278197001593 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 278197001594 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 278197001595 HPr interaction site; other site 278197001596 glycerol kinase (GK) interaction site [polypeptide binding]; other site 278197001597 active site 278197001598 phosphorylation site [posttranslational modification] 278197001599 sucrose-6-phosphate hydrolase; Region: scrB_fam; TIGR01322 278197001600 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 278197001601 substrate binding [chemical binding]; other site 278197001602 active site 278197001603 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 278197001604 Transcriptional regulators [Transcription]; Region: PurR; COG1609 278197001605 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 278197001606 DNA binding site [nucleotide binding] 278197001607 domain linker motif; other site 278197001608 Ligand binding domain of the lacI-like transcription regulator from a novel metal-reducing bacterium Alkaliphilus Metalliredigens (strain Qymf) and its close homologs; Region: PBP1_Qymf_like; cd06291 278197001609 dimerization interface [polypeptide binding]; other site 278197001610 ligand binding site [chemical binding]; other site 278197001611 sodium binding site [ion binding]; other site 278197001612 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 278197001613 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 278197001614 Ca binding site [ion binding]; other site 278197001615 active site 278197001616 catalytic site [active] 278197001617 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 278197001618 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 278197001619 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 278197001620 Transposase; Region: HTH_Tnp_1; pfam01527 278197001621 DDE domain; Region: DDE_Tnp_IS240; pfam13610 278197001622 Integrase core domain; Region: rve; pfam00665 278197001623 Integrase core domain; Region: rve_3; pfam13683 278197001624 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 278197001625 non-specific DNA binding site [nucleotide binding]; other site 278197001626 salt bridge; other site 278197001627 sequence-specific DNA binding site [nucleotide binding]; other site 278197001628 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK07251 278197001629 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 278197001630 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 278197001631 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 278197001632 putative active site [active] 278197001633 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 278197001634 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 278197001635 cofactor binding site; other site 278197001636 DNA binding site [nucleotide binding] 278197001637 substrate interaction site [chemical binding]; other site 278197001638 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 278197001639 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 278197001640 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 278197001641 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_a; cd09179 278197001642 PLD-like domain; Region: PLDc_2; pfam13091 278197001643 putative active site [active] 278197001644 catalytic site [active] 278197001645 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 278197001646 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 278197001647 nucleotide binding region [chemical binding]; other site 278197001648 ATP-binding site [chemical binding]; other site 278197001649 AAA domain; Region: AAA_30; pfam13604 278197001650 Helix-turn-helix domain; Region: HTH_17; cl17695 278197001651 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 278197001652 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 278197001653 Int/Topo IB signature motif; other site 278197001654 LicD family; Region: LicD; pfam04991 278197001655 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 278197001656 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 278197001657 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197001658 NAD(P) binding site [chemical binding]; other site 278197001659 active site 278197001660 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 278197001661 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 278197001662 DNA binding residues [nucleotide binding] 278197001663 putative dimer interface [polypeptide binding]; other site 278197001664 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 278197001665 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 278197001666 putative dimer interface [polypeptide binding]; other site 278197001667 putative anticodon binding site; other site 278197001668 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 278197001669 homodimer interface [polypeptide binding]; other site 278197001670 motif 1; other site 278197001671 motif 2; other site 278197001672 active site 278197001673 motif 3; other site 278197001674 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 278197001675 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 278197001676 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 278197001677 Coenzyme A binding pocket [chemical binding]; other site 278197001678 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 278197001679 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 278197001680 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 278197001681 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904 278197001682 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197001683 putative substrate translocation pore; other site 278197001684 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 278197001685 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 278197001686 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 278197001687 CsbD-like; Region: CsbD; pfam05532 278197001688 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 278197001689 substrate binding site [chemical binding]; other site 278197001690 multimerization interface [polypeptide binding]; other site 278197001691 ATP binding site [chemical binding]; other site 278197001692 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 278197001693 dimer interface [polypeptide binding]; other site 278197001694 substrate binding site [chemical binding]; other site 278197001695 ATP binding site [chemical binding]; other site 278197001696 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 278197001697 thiamine phosphate binding site [chemical binding]; other site 278197001698 active site 278197001699 pyrophosphate binding site [ion binding]; other site 278197001700 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 278197001701 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 278197001702 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 278197001703 ATP binding site [chemical binding]; other site 278197001704 putative Mg++ binding site [ion binding]; other site 278197001705 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 278197001706 nucleotide binding region [chemical binding]; other site 278197001707 ATP-binding site [chemical binding]; other site 278197001708 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 278197001709 HRDC domain; Region: HRDC; pfam00570 278197001710 Zinc-dependent metalloprotease, MMP_like subfamily. This group contains matrix metalloproteinases (MMPs), serralysins, and the astacin_like family of proteases; Region: ZnMc_MMP_like; cd04268 278197001711 active site 278197001712 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 278197001713 Beta-lactamase; Region: Beta-lactamase; pfam00144 278197001714 Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944 278197001715 Chain length determinant protein; Region: Wzz; cl15801 278197001716 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 278197001717 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 278197001718 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 278197001719 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 278197001720 active site 278197001721 exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025 278197001722 Bacterial sugar transferase; Region: Bac_transf; pfam02397 278197001723 Domain of unknown function (DUF4422); Region: DUF4422; pfam14393 278197001724 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 278197001725 This family is most closely related to the GT1 family of glycosyltransferases. capH in Staphylococcus aureus has been shown to be required for the biosynthesis of the type 1 capsular polysaccharide (CP1); Region: GT1_CapH_like; cd03812 278197001726 putative ADP-binding pocket [chemical binding]; other site 278197001727 Protein of unknown function (DUF3184); Region: DUF3184; pfam11380 278197001728 beta-1,6-galactofuranosyltransferase; Provisional; Region: PRK09814 278197001729 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 278197001730 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 278197001731 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 278197001732 UDP-galactopyranose mutase; Region: GLF; pfam03275 278197001733 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 278197001734 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 278197001735 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 278197001736 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 278197001737 active site 278197001738 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 278197001739 Acyltransferase family; Region: Acyl_transf_3; pfam01757 278197001740 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 278197001741 active site 278197001742 P-loop; other site 278197001743 phosphorylation site [posttranslational modification] 278197001744 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 278197001745 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 278197001746 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 278197001747 active site 278197001748 methionine cluster; other site 278197001749 phosphorylation site [posttranslational modification] 278197001750 metal binding site [ion binding]; metal-binding site 278197001751 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 278197001752 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 278197001753 PRD domain; Region: PRD; pfam00874 278197001754 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 278197001755 active site 278197001756 phosphorylation site [posttranslational modification] 278197001757 VanZ like family; Region: VanZ; cl01971 278197001758 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 278197001759 Predicted transcriptional regulator [Transcription]; Region: COG2378 278197001760 HTH domain; Region: HTH_11; pfam08279 278197001761 WYL domain; Region: WYL; pfam13280 278197001762 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 278197001763 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_2; cd06419 278197001764 active site 278197001765 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 278197001766 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 278197001767 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 278197001768 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 278197001769 ATP binding site [chemical binding]; other site 278197001770 putative Mg++ binding site [ion binding]; other site 278197001771 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 278197001772 nucleotide binding region [chemical binding]; other site 278197001773 ATP-binding site [chemical binding]; other site 278197001774 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 278197001775 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05458 278197001776 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 278197001777 active site 278197001778 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 278197001779 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 278197001780 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 278197001781 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 278197001782 active site 278197001783 homodimer interface [polypeptide binding]; other site 278197001784 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 278197001785 RecX family; Region: RecX; cl00936 278197001786 hypothetical protein; Provisional; Region: PRK13662 278197001787 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 278197001788 Domain of unknown function DUF20; Region: UPF0118; pfam01594 278197001789 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 278197001790 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 278197001791 active site 278197001792 nucleotide binding site [chemical binding]; other site 278197001793 HIGH motif; other site 278197001794 KMSKS motif; other site 278197001795 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 278197001796 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 278197001797 G1 box; other site 278197001798 putative GEF interaction site [polypeptide binding]; other site 278197001799 GTP/Mg2+ binding site [chemical binding]; other site 278197001800 Switch I region; other site 278197001801 G2 box; other site 278197001802 G3 box; other site 278197001803 Switch II region; other site 278197001804 G4 box; other site 278197001805 G5 box; other site 278197001806 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 278197001807 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 278197001808 Sulfatase; Region: Sulfatase; pfam00884 278197001809 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 278197001810 Protein of unknown function (DUF1634); Region: DUF1634; pfam07843 278197001811 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278197001812 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 278197001813 Walker A motif; other site 278197001814 ATP binding site [chemical binding]; other site 278197001815 Walker B motif; other site 278197001816 arginine finger; other site 278197001817 UvrB/uvrC motif; Region: UVR; pfam02151 278197001818 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278197001819 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 278197001820 Walker A motif; other site 278197001821 ATP binding site [chemical binding]; other site 278197001822 Walker B motif; other site 278197001823 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 278197001824 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 278197001825 dimerization domain swap beta strand [polypeptide binding]; other site 278197001826 regulatory protein interface [polypeptide binding]; other site 278197001827 active site 278197001828 regulatory phosphorylation site [posttranslational modification]; other site 278197001829 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 278197001830 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 278197001831 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 278197001832 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 278197001833 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278197001834 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 278197001835 This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817 278197001836 putative ADP-binding pocket [chemical binding]; other site 278197001837 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 278197001838 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 278197001839 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 278197001840 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 278197001841 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 278197001842 PYR/PP interface [polypeptide binding]; other site 278197001843 dimer interface [polypeptide binding]; other site 278197001844 tetramer interface [polypeptide binding]; other site 278197001845 TPP binding site [chemical binding]; other site 278197001846 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 278197001847 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 278197001848 TPP-binding site [chemical binding]; other site 278197001849 S-adenosylmethionine synthetase; Validated; Region: PRK05250 278197001850 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 278197001851 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 278197001852 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 278197001853 Major Facilitator Superfamily; Region: MFS_1; pfam07690 278197001854 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197001855 putative substrate translocation pore; other site 278197001856 Methyltransferase domain; Region: Methyltransf_31; pfam13847 278197001857 Putative rRNA methylase; Region: rRNA_methylase; pfam06962 278197001858 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 278197001859 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 278197001860 active site 278197001861 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 278197001862 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 278197001863 HIGH motif; other site 278197001864 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 278197001865 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 278197001866 active site 278197001867 KMSKS motif; other site 278197001868 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 278197001869 tRNA binding surface [nucleotide binding]; other site 278197001870 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 278197001871 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 278197001872 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 278197001873 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 278197001874 RNA binding surface [nucleotide binding]; other site 278197001875 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 278197001876 active site 278197001877 uracil binding [chemical binding]; other site 278197001878 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 278197001879 putative substrate binding site [chemical binding]; other site 278197001880 putative ATP binding site [chemical binding]; other site 278197001881 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 278197001882 Ligand Binding Site [chemical binding]; other site 278197001883 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 278197001884 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 278197001885 Substrate-binding site [chemical binding]; other site 278197001886 Substrate specificity [chemical binding]; other site 278197001887 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 278197001888 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278197001889 active site 278197001890 motif I; other site 278197001891 motif II; other site 278197001892 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 278197001893 Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124 278197001894 active site 278197001895 zinc binding site [ion binding]; other site 278197001896 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 278197001897 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 278197001898 active site 278197001899 dimer interface [polypeptide binding]; other site 278197001900 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 278197001901 Ligand Binding Site [chemical binding]; other site 278197001902 Molecular Tunnel; other site 278197001903 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 278197001904 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 278197001905 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 278197001906 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 278197001907 Predicted ATP-grasp enzyme [General function prediction only]; Region: COG3919 278197001908 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 278197001909 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 278197001910 aspartate racemase; Region: asp_race; TIGR00035 278197001911 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 278197001912 DNA/RNA non-specific endonuclease; Region: Endonuclea_NS_2; cl17626 278197001913 Amino acid permease; Region: AA_permease_2; pfam13520 278197001914 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278197001915 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 278197001916 active site 278197001917 motif I; other site 278197001918 motif II; other site 278197001919 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278197001920 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 278197001921 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 278197001922 active site 278197001923 catalytic tetrad [active] 278197001924 arginyl-tRNA synthetase; Reviewed; Region: PRK12451 278197001925 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 278197001926 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 278197001927 active site 278197001928 HIGH motif; other site 278197001929 KMSK motif region; other site 278197001930 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 278197001931 tRNA binding surface [nucleotide binding]; other site 278197001932 anticodon binding site; other site 278197001933 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 278197001934 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 278197001935 ligand binding site [chemical binding]; other site 278197001936 flexible hinge region; other site 278197001937 Arginine repressor [Transcription]; Region: ArgR; COG1438 278197001938 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 278197001939 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 278197001940 Transglycosylase; Region: Transgly; pfam00912 278197001941 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 278197001942 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 278197001943 hypothetical protein; Provisional; Region: PRK13676 278197001944 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 278197001945 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 278197001946 active site 278197001947 metal binding site [ion binding]; metal-binding site 278197001948 DNA binding site [nucleotide binding] 278197001949 AAA domain; Region: AAA_23; pfam13476 278197001950 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 278197001951 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 278197001952 generic binding surface II; other site 278197001953 generic binding surface I; other site 278197001954 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 278197001955 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 278197001956 Zn2+ binding site [ion binding]; other site 278197001957 Mg2+ binding site [ion binding]; other site 278197001958 peptidylprolyl isomerase; Provisional; Region: prsA; PRK04405 278197001959 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 278197001960 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 278197001961 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 278197001962 HIT family signature motif; other site 278197001963 catalytic residue [active] 278197001964 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 278197001965 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 278197001966 Walker A/P-loop; other site 278197001967 ATP binding site [chemical binding]; other site 278197001968 Q-loop/lid; other site 278197001969 ABC transporter signature motif; other site 278197001970 Walker B; other site 278197001971 D-loop; other site 278197001972 H-loop/switch region; other site 278197001973 Bacterial ABC transporter protein EcsB; Region: EcsB; pfam05975 278197001974 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278197001975 S-adenosylmethionine binding site [chemical binding]; other site 278197001976 Predicted small secreted protein [Function unknown]; Region: COG5584 278197001977 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 278197001978 putative tRNA-binding site [nucleotide binding]; other site 278197001979 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 278197001980 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 278197001981 This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843 278197001982 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 278197001983 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 278197001984 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 278197001985 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 278197001986 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 278197001987 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 278197001988 DNA polymerase I; Provisional; Region: PRK05755 278197001989 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 278197001990 active site 278197001991 metal binding site 1 [ion binding]; metal-binding site 278197001992 putative 5' ssDNA interaction site; other site 278197001993 metal binding site 3; metal-binding site 278197001994 metal binding site 2 [ion binding]; metal-binding site 278197001995 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 278197001996 putative DNA binding site [nucleotide binding]; other site 278197001997 putative metal binding site [ion binding]; other site 278197001998 inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140 278197001999 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 278197002000 active site 278197002001 DNA binding site [nucleotide binding] 278197002002 catalytic site [active] 278197002003 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 278197002004 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 278197002005 DNA binding site [nucleotide binding] 278197002006 catalytic residue [active] 278197002007 H2TH interface [polypeptide binding]; other site 278197002008 putative catalytic residues [active] 278197002009 turnover-facilitating residue; other site 278197002010 intercalation triad [nucleotide binding]; other site 278197002011 8OG recognition residue [nucleotide binding]; other site 278197002012 putative reading head residues; other site 278197002013 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 278197002014 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 278197002015 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 278197002016 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 278197002017 CoA-binding site [chemical binding]; other site 278197002018 ATP-binding [chemical binding]; other site 278197002019 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 278197002020 ATP cone domain; Region: ATP-cone; pfam03477 278197002021 Replication initiation/membrane attachment protein [DNA replication, recombination, and repair]; Region: DnaB; COG3611 278197002022 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 278197002023 primosomal protein DnaI; Reviewed; Region: PRK08939 278197002024 Primosomal protein DnaI N-terminus; Region: DnaI_N; pfam07319 278197002025 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278197002026 Walker A motif; other site 278197002027 ATP binding site [chemical binding]; other site 278197002028 Walker B motif; other site 278197002029 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 278197002030 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 278197002031 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 278197002032 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 278197002033 active site 278197002034 dimer interface [polypeptide binding]; other site 278197002035 motif 1; other site 278197002036 motif 2; other site 278197002037 motif 3; other site 278197002038 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 278197002039 anticodon binding site; other site 278197002040 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 278197002041 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 278197002042 GAF domain; Region: GAF_3; pfam13492 278197002043 Histidine kinase; Region: His_kinase; pfam06580 278197002044 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278197002045 ATP binding site [chemical binding]; other site 278197002046 Mg2+ binding site [ion binding]; other site 278197002047 G-X-G motif; other site 278197002048 two-component response regulator; Provisional; Region: PRK14084 278197002049 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278197002050 active site 278197002051 phosphorylation site [posttranslational modification] 278197002052 intermolecular recognition site; other site 278197002053 dimerization interface [polypeptide binding]; other site 278197002054 LytTr DNA-binding domain; Region: LytTR; smart00850 278197002055 LrgA family; Region: LrgA; cl00608 278197002056 LrgB-like family; Region: LrgB; cl00596 278197002057 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 278197002058 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 278197002059 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 278197002060 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 278197002061 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 278197002062 23S rRNA binding site [nucleotide binding]; other site 278197002063 L21 binding site [polypeptide binding]; other site 278197002064 L13 binding site [polypeptide binding]; other site 278197002065 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 278197002066 alcohol dehydrogenase and quinone reductase-like medium chain degydrogenases/reductases; Region: MDR_like_2; cd05289 278197002067 putative NAD(P) binding site [chemical binding]; other site 278197002068 Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179 278197002069 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278197002070 active site 278197002071 motif I; other site 278197002072 motif II; other site 278197002073 GTPase YqeH; Provisional; Region: PRK13796 278197002074 Circularly permuted YqeH GTPase; Region: YqeH; cd01855 278197002075 GTP/Mg2+ binding site [chemical binding]; other site 278197002076 G4 box; other site 278197002077 G5 box; other site 278197002078 G1 box; other site 278197002079 Switch I region; other site 278197002080 G2 box; other site 278197002081 G3 box; other site 278197002082 Switch II region; other site 278197002083 Escherichia coli YhbY is associated with pre-50S ribosomal subunits, which implies a function in ribosome assembly; Region: CRS1_YhbY; smart01103 278197002084 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 278197002085 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 278197002086 active site 278197002087 (T/H)XGH motif; other site 278197002088 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 278197002089 Zn2+ binding site [ion binding]; other site 278197002090 Mg2+ binding site [ion binding]; other site 278197002091 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 278197002092 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 278197002093 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278197002094 S-adenosylmethionine binding site [chemical binding]; other site 278197002095 hypothetical protein; Provisional; Region: PRK13670 278197002096 HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673 278197002097 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 278197002098 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 278197002099 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 278197002100 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 278197002101 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 278197002102 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 278197002103 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278197002104 active site 278197002105 phosphorylation site [posttranslational modification] 278197002106 intermolecular recognition site; other site 278197002107 dimerization interface [polypeptide binding]; other site 278197002108 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 278197002109 DNA binding site [nucleotide binding] 278197002110 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 278197002111 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 278197002112 dimerization interface [polypeptide binding]; other site 278197002113 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 278197002114 dimer interface [polypeptide binding]; other site 278197002115 phosphorylation site [posttranslational modification] 278197002116 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278197002117 ATP binding site [chemical binding]; other site 278197002118 Mg2+ binding site [ion binding]; other site 278197002119 G-X-G motif; other site 278197002120 OxaA-like protein precursor; Provisional; Region: PRK02463 278197002121 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 278197002122 Acylphosphatase; Region: Acylphosphatase; pfam00708 278197002123 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 278197002124 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 278197002125 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 278197002126 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 278197002127 Predicted transcriptional regulators [Transcription]; Region: COG1733 278197002128 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 278197002129 dimerization interface [polypeptide binding]; other site 278197002130 putative DNA binding site [nucleotide binding]; other site 278197002131 putative Zn2+ binding site [ion binding]; other site 278197002132 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 278197002133 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 278197002134 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 278197002135 dimer interface [polypeptide binding]; other site 278197002136 motif 1; other site 278197002137 active site 278197002138 motif 2; other site 278197002139 motif 3; other site 278197002140 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 278197002141 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 278197002142 putative tRNA-binding site [nucleotide binding]; other site 278197002143 B3/4 domain; Region: B3_4; pfam03483 278197002144 tRNA synthetase B5 domain; Region: B5; smart00874 278197002145 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 278197002146 dimer interface [polypeptide binding]; other site 278197002147 motif 1; other site 278197002148 motif 3; other site 278197002149 motif 2; other site 278197002150 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 278197002151 YceG-like family; Region: YceG; pfam02618 278197002152 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 278197002153 dimerization interface [polypeptide binding]; other site 278197002154 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 278197002155 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 278197002156 Sugar specificity; other site 278197002157 Pyrimidine base specificity; other site 278197002158 ATP-binding site [chemical binding]; other site 278197002159 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 278197002160 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 278197002161 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 278197002162 Bacterial membrane protein YfhO; Region: YfhO; pfam09586 278197002163 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 278197002164 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 278197002165 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 278197002166 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 278197002167 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 278197002168 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 278197002169 Rhomboid family; Region: Rhomboid; pfam01694 278197002170 Bacterial protein of unknown function (DUF910); Region: DUF910; pfam06014 278197002171 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 278197002172 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 278197002173 nucleotide binding site [chemical binding]; other site 278197002174 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 278197002175 active site residue [active] 278197002176 Protein of unknown function (DUF3042); Region: DUF3042; pfam11240 278197002177 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 278197002178 Glycerophosphodiester phosphodiesterase domain of Thermoanaerobacter tengcongensis and similar proteins; Region: GDPD_TtGDE_like; cd08563 278197002179 active site 278197002180 catalytic site [active] 278197002181 metal binding site [ion binding]; metal-binding site 278197002182 dimer interface [polypeptide binding]; other site 278197002183 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 278197002184 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 278197002185 Aluminium resistance protein; Region: Alum_res; pfam06838 278197002186 Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100 278197002187 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 278197002188 DNA binding residues [nucleotide binding] 278197002189 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 278197002190 putative dimer interface [polypeptide binding]; other site 278197002191 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 278197002192 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 278197002193 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 278197002194 dUTPase; Region: dUTPase_2; pfam08761 278197002195 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in dimeric 2-Deoxyuridine 5'-triphosphate nucleotidohydrolase and similar proteins; Region: NTP-PPase_dUTPase; cd11527 278197002196 active site 278197002197 homodimer interface [polypeptide binding]; other site 278197002198 metal binding site [ion binding]; metal-binding site 278197002199 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain superfamily; Region: NTP-PPase; cl16941 278197002200 integrase; Provisional; Region: int; PHA02601 278197002201 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 278197002202 Int/Topo IB signature motif; other site 278197002203 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 278197002204 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 278197002205 non-specific DNA binding site [nucleotide binding]; other site 278197002206 salt bridge; other site 278197002207 sequence-specific DNA binding site [nucleotide binding]; other site 278197002208 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 278197002209 non-specific DNA binding site [nucleotide binding]; other site 278197002210 salt bridge; other site 278197002211 sequence-specific DNA binding site [nucleotide binding]; other site 278197002212 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 278197002213 ORF6C domain; Region: ORF6C; pfam10552 278197002214 Domain of unknown function (DUF771); Region: DUF771; pfam05595 278197002215 ERF superfamily; Region: ERF; pfam04404 278197002216 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 278197002217 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 278197002218 dimer interface [polypeptide binding]; other site 278197002219 ssDNA binding site [nucleotide binding]; other site 278197002220 tetramer (dimer of dimers) interface [polypeptide binding]; other site 278197002221 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 278197002222 replicative DNA helicase; Region: DnaB; TIGR00665 278197002223 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 278197002224 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 278197002225 Walker A motif; other site 278197002226 ATP binding site [chemical binding]; other site 278197002227 Walker B motif; other site 278197002228 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 278197002229 Protein of unknown function (DUF1642); Region: DUF1642; pfam07852 278197002230 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 278197002231 DNA binding residues [nucleotide binding] 278197002232 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 278197002233 YfbU domain; Region: YfbU; cl01137 278197002234 Homeodomain-like domain; Region: HTH_23; pfam13384 278197002235 Phage terminase large subunit; Region: Terminase_3; cl12054 278197002236 Terminase-like family; Region: Terminase_6; pfam03237 278197002237 Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133 278197002238 phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538 278197002239 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 278197002240 Domain of unknown function (DUF4355); Region: DUF4355; pfam14265 278197002241 Phage gp6-like head-tail connector protein; Region: Phage_connect_1; pfam05135 278197002242 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 278197002243 Phage major tail protein 2; Region: Phage_tail_2; pfam06199 278197002244 Phage protein; Region: DUF3647; pfam12363 278197002245 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 278197002246 Phage tail protein; Region: Sipho_tail; cl17486 278197002247 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 278197002248 N-acetyl-D-glucosamine binding site [chemical binding]; other site 278197002249 catalytic residue [active] 278197002250 Peptidase family M23; Region: Peptidase_M23; pfam01551 278197002251 Bacteriophage peptidoglycan hydrolase; Region: Amidase_5; pfam05382 278197002252 Uncharacterized conserved protein [Function unknown]; Region: COG3334 278197002253 Domain of unknown function (DUF2479); Region: DUF2479; pfam10651 278197002254 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 278197002255 Protein of unknown function (DUF2977); Region: DUF2977; pfam11192 278197002256 Phage uncharacterized protein (Phage_XkdX); Region: Phage_XkdX; pfam09693 278197002257 Holin family; Region: Phage_holin_4; pfam05105 278197002258 Cpl-1 lysin (also known as Cpl-9 lysozyme / muramidase) is a bacterial cell wall endolysin encoded by the pneumococcal bacteriophage Cp-1, which cleaves the glycosidic N-acetylmuramoyl-(beta1,4)-N-acetylglucosamine bonds of the pneumococcal glycan chain; Region: GH25_Cpl1-like; cd06415 278197002259 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 278197002260 active site 278197002261 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278197002262 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 278197002263 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 278197002264 Protein of unknown function (DUF464); Region: DUF464; pfam04327 278197002265 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 278197002266 elongation factor P; Validated; Region: PRK00529 278197002267 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 278197002268 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 278197002269 RNA binding site [nucleotide binding]; other site 278197002270 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 278197002271 RNA binding site [nucleotide binding]; other site 278197002272 Asp23 family; Region: Asp23; pfam03780 278197002273 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 278197002274 putative RNA binding site [nucleotide binding]; other site 278197002275 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14190 278197002276 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 278197002277 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 278197002278 homodimer interface [polypeptide binding]; other site 278197002279 NADP binding site [chemical binding]; other site 278197002280 substrate binding site [chemical binding]; other site 278197002281 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 278197002282 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 278197002283 generic binding surface II; other site 278197002284 generic binding surface I; other site 278197002285 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 278197002286 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 278197002287 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 278197002288 substrate binding pocket [chemical binding]; other site 278197002289 chain length determination region; other site 278197002290 substrate-Mg2+ binding site; other site 278197002291 catalytic residues [active] 278197002292 aspartate-rich region 1; other site 278197002293 active site lid residues [active] 278197002294 aspartate-rich region 2; other site 278197002295 Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189 278197002296 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 278197002297 RNA binding surface [nucleotide binding]; other site 278197002298 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 278197002299 Arginine repressor [Transcription]; Region: ArgR; COG1438 278197002300 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 278197002301 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 278197002302 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 278197002303 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 278197002304 Walker A/P-loop; other site 278197002305 ATP binding site [chemical binding]; other site 278197002306 Q-loop/lid; other site 278197002307 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 278197002308 ABC transporter signature motif; other site 278197002309 Walker B; other site 278197002310 D-loop; other site 278197002311 H-loop/switch region; other site 278197002312 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 278197002313 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 278197002314 catalytic site [active] 278197002315 G-X2-G-X-G-K; other site 278197002316 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 278197002317 Flavoprotein; Region: Flavoprotein; pfam02441 278197002318 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 278197002319 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 278197002320 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 278197002321 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 278197002322 ATP binding site [chemical binding]; other site 278197002323 putative Mg++ binding site [ion binding]; other site 278197002324 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 278197002325 ATP-binding site [chemical binding]; other site 278197002326 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 278197002327 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 278197002328 putative active site [active] 278197002329 substrate binding site [chemical binding]; other site 278197002330 putative cosubstrate binding site; other site 278197002331 catalytic site [active] 278197002332 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 278197002333 substrate binding site [chemical binding]; other site 278197002334 16S rRNA methyltransferase B; Provisional; Region: PRK14902 278197002335 NusB family; Region: NusB; pfam01029 278197002336 putative RNA binding site [nucleotide binding]; other site 278197002337 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278197002338 S-adenosylmethionine binding site [chemical binding]; other site 278197002339 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 278197002340 active site 278197002341 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 278197002342 Catalytic domain of Protein Kinases; Region: PKc; cd00180 278197002343 active site 278197002344 ATP binding site [chemical binding]; other site 278197002345 substrate binding site [chemical binding]; other site 278197002346 activation loop (A-loop); other site 278197002347 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 278197002348 PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577 278197002349 GTPase RsgA; Reviewed; Region: PRK00098 278197002350 S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466 278197002351 RNA binding site [nucleotide binding]; other site 278197002352 homodimer interface [polypeptide binding]; other site 278197002353 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 278197002354 GTPase/Zn-binding domain interface [polypeptide binding]; other site 278197002355 GTP/Mg2+ binding site [chemical binding]; other site 278197002356 G4 box; other site 278197002357 G5 box; other site 278197002358 G1 box; other site 278197002359 Switch I region; other site 278197002360 G2 box; other site 278197002361 G3 box; other site 278197002362 Switch II region; other site 278197002363 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 278197002364 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 278197002365 substrate binding site [chemical binding]; other site 278197002366 hexamer interface [polypeptide binding]; other site 278197002367 metal binding site [ion binding]; metal-binding site 278197002368 Thiamine pyrophosphokinase; Region: TPK; cd07995 278197002369 thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378 278197002370 active site 278197002371 dimerization interface [polypeptide binding]; other site 278197002372 thiamine binding site [chemical binding]; other site 278197002373 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 278197002374 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1302 278197002375 DAK2 domain fusion protein YloV; Region: YloV; TIGR03599 278197002376 DAK2 domain; Region: Dak2; pfam02734 278197002377 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 278197002378 RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966 278197002379 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 278197002380 generic binding surface II; other site 278197002381 ssDNA binding site; other site 278197002382 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 278197002383 ATP binding site [chemical binding]; other site 278197002384 putative Mg++ binding site [ion binding]; other site 278197002385 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 278197002386 nucleotide binding region [chemical binding]; other site 278197002387 ATP-binding site [chemical binding]; other site 278197002388 putative phosphate acyltransferase; Provisional; Region: PRK05331 278197002389 acyl carrier protein; Provisional; Region: acpP; PRK00982 278197002390 ribonuclease III; Reviewed; Region: rnc; PRK00102 278197002391 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 278197002392 dimerization interface [polypeptide binding]; other site 278197002393 active site 278197002394 metal binding site [ion binding]; metal-binding site 278197002395 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 278197002396 dsRNA binding site [nucleotide binding]; other site 278197002397 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 278197002398 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 278197002399 Walker A/P-loop; other site 278197002400 ATP binding site [chemical binding]; other site 278197002401 Q-loop/lid; other site 278197002402 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 278197002403 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 278197002404 ABC transporter signature motif; other site 278197002405 Walker B; other site 278197002406 D-loop; other site 278197002407 H-loop/switch region; other site 278197002408 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 278197002409 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 278197002410 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 278197002411 P loop; other site 278197002412 GTP binding site [chemical binding]; other site 278197002413 putative DNA-binding protein; Validated; Region: PRK00118 278197002414 Putative helix-turn-helix protein, YlxM / p13 like; Region: UPF0122; pfam04297 278197002415 signal recognition particle protein; Provisional; Region: PRK10867 278197002416 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 278197002417 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 278197002418 GTP binding site [chemical binding]; other site 278197002419 Signal peptide binding domain; Region: SRP_SPB; pfam02978 278197002420 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 278197002421 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 278197002422 RimM N-terminal domain; Region: RimM; pfam01782 278197002423 PRC-barrel domain; Region: PRC; pfam05239 278197002424 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 278197002425 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 278197002426 DsrE/DsrF-like family; Region: DrsE; cl00672 278197002427 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 278197002428 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 278197002429 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 278197002430 dimer interface [polypeptide binding]; other site 278197002431 active site 278197002432 CoA binding pocket [chemical binding]; other site 278197002433 acyl carrier protein; Provisional; Region: acpP; PRK00982 278197002434 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 278197002435 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 278197002436 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197002437 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 278197002438 NAD(P) binding site [chemical binding]; other site 278197002439 active site 278197002440 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 278197002441 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 278197002442 dimer interface [polypeptide binding]; other site 278197002443 active site 278197002444 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 278197002445 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 278197002446 carboxyltransferase (CT) interaction site; other site 278197002447 biotinylation site [posttranslational modification]; other site 278197002448 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 278197002449 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 278197002450 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 278197002451 ATP-grasp domain; Region: ATP-grasp_4; cl17255 278197002452 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 278197002453 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 278197002454 Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115 278197002455 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 278197002456 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 278197002457 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK06079 278197002458 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 278197002459 NAD binding site [chemical binding]; other site 278197002460 homotetramer interface [polypeptide binding]; other site 278197002461 homodimer interface [polypeptide binding]; other site 278197002462 substrate binding site [chemical binding]; other site 278197002463 active site 278197002464 putative transport protein YifK; Provisional; Region: PRK10746 278197002465 "initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827 278197002466 3-hydroxy-3-methylglutaryl CoA synthase, prokaryotic clade; Region: HMG-CoA-S_prok; TIGR01835 278197002467 dimer interface [polypeptide binding]; other site 278197002468 active site 278197002469 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 278197002470 LexA repressor; Validated; Region: PRK00215 278197002471 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 278197002472 Catalytic site [active] 278197002473 Bacterial protein of unknown function (DUF896); Region: DUF896; pfam05979 278197002474 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3763 278197002475 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 278197002476 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 278197002477 putative acyl-acceptor binding pocket; other site 278197002478 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 278197002479 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278197002480 S-adenosylmethionine binding site [chemical binding]; other site 278197002481 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 278197002482 GIY-YIG motif/motif A; other site 278197002483 putative active site [active] 278197002484 putative metal binding site [ion binding]; other site 278197002485 D-Lactate dehydrogenase and D-2-Hydroxyisocaproic acid dehydrogenase (D-HicDH), NAD-binding and catalytic domains; Region: LDH; cd12186 278197002486 D-lactate dehydrogenase; Validated; Region: PRK08605 278197002487 homodimer interface [polypeptide binding]; other site 278197002488 ligand binding site [chemical binding]; other site 278197002489 NAD binding site [chemical binding]; other site 278197002490 catalytic site [active] 278197002491 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 278197002492 rRNA interaction site [nucleotide binding]; other site 278197002493 S8 interaction site; other site 278197002494 putative laminin-1 binding site; other site 278197002495 elongation factor Ts; Provisional; Region: tsf; PRK09377 278197002496 UBA/TS-N domain; Region: UBA; pfam00627 278197002497 Elongation factor TS; Region: EF_TS; pfam00889 278197002498 Elongation factor TS; Region: EF_TS; pfam00889 278197002499 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 278197002500 putative nucleotide binding site [chemical binding]; other site 278197002501 uridine monophosphate binding site [chemical binding]; other site 278197002502 homohexameric interface [polypeptide binding]; other site 278197002503 ribosome recycling factor; Reviewed; Region: frr; PRK00083 278197002504 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 278197002505 hinge region; other site 278197002506 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 278197002507 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 278197002508 catalytic residue [active] 278197002509 putative FPP diphosphate binding site; other site 278197002510 putative FPP binding hydrophobic cleft; other site 278197002511 dimer interface [polypeptide binding]; other site 278197002512 putative IPP diphosphate binding site; other site 278197002513 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 278197002514 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 278197002515 RIP metalloprotease RseP; Region: TIGR00054 278197002516 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 278197002517 active site 278197002518 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 278197002519 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 278197002520 protein binding site [polypeptide binding]; other site 278197002521 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 278197002522 putative substrate binding region [chemical binding]; other site 278197002523 prolyl-tRNA synthetase; Provisional; Region: PRK09194 278197002524 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 278197002525 dimer interface [polypeptide binding]; other site 278197002526 motif 1; other site 278197002527 active site 278197002528 motif 2; other site 278197002529 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 278197002530 putative deacylase active site [active] 278197002531 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 278197002532 active site 278197002533 motif 3; other site 278197002534 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 278197002535 anticodon binding site; other site 278197002536 DNA polymerase III PolC; Validated; Region: polC; PRK00448 278197002537 DNA polymerase III polC-type N-terminus; Region: DNA_pol3_alph_N; pfam11490 278197002538 polC_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold nucleic acid binding domain of Bacillus subtilis type C replicative DNA polymerase III alpha subunit (polC). Replication in B. subtilis and Staphylococcus aureus requires two...; Region: polC_OBF; cd04484 278197002539 generic binding surface II; other site 278197002540 generic binding surface I; other site 278197002541 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 278197002542 active site 278197002543 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 278197002544 active site 278197002545 catalytic site [active] 278197002546 substrate binding site [chemical binding]; other site 278197002547 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435 278197002548 ribosome maturation protein RimP; Reviewed; Region: PRK00092 278197002549 Sm and related proteins; Region: Sm_like; cl00259 278197002550 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 278197002551 putative oligomer interface [polypeptide binding]; other site 278197002552 putative RNA binding site [nucleotide binding]; other site 278197002553 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 278197002554 NusA N-terminal domain; Region: NusA_N; pfam08529 278197002555 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 278197002556 RNA binding site [nucleotide binding]; other site 278197002557 homodimer interface [polypeptide binding]; other site 278197002558 NusA-like KH domain; Region: KH_5; pfam13184 278197002559 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 278197002560 G-X-X-G motif; other site 278197002561 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 278197002562 putative RNA binding cleft [nucleotide binding]; other site 278197002563 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 278197002564 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 278197002565 translation initiation factor IF-2; Region: IF-2; TIGR00487 278197002566 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 278197002567 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 278197002568 G1 box; other site 278197002569 putative GEF interaction site [polypeptide binding]; other site 278197002570 GTP/Mg2+ binding site [chemical binding]; other site 278197002571 Switch I region; other site 278197002572 G2 box; other site 278197002573 G3 box; other site 278197002574 Switch II region; other site 278197002575 G4 box; other site 278197002576 G5 box; other site 278197002577 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 278197002578 Translation-initiation factor 2; Region: IF-2; pfam11987 278197002579 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 278197002580 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 278197002581 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK01550 278197002582 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 278197002583 RNA binding site [nucleotide binding]; other site 278197002584 active site 278197002585 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 278197002586 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 278197002587 active site 278197002588 Riboflavin kinase; Region: Flavokinase; smart00904 278197002589 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 278197002590 GrpE; Region: GrpE; pfam01025 278197002591 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 278197002592 dimer interface [polypeptide binding]; other site 278197002593 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 278197002594 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 278197002595 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 278197002596 nucleotide binding site [chemical binding]; other site 278197002597 NEF interaction site [polypeptide binding]; other site 278197002598 SBD interface [polypeptide binding]; other site 278197002599 chaperone protein DnaJ; Provisional; Region: PRK14276 278197002600 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 278197002601 HSP70 interaction site [polypeptide binding]; other site 278197002602 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 278197002603 substrate binding site [polypeptide binding]; other site 278197002604 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 278197002605 Zn binding sites [ion binding]; other site 278197002606 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 278197002607 substrate binding site [polypeptide binding]; other site 278197002608 dimer interface [polypeptide binding]; other site 278197002609 Domain of unknown function (DUF378); Region: DUF378; pfam04070 278197002610 TspO/MBR family; Region: TspO_MBR; pfam03073 278197002611 QueT transporter; Region: QueT; pfam06177 278197002612 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 278197002613 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK06550 278197002614 classical (c) SDRs; Region: SDR_c; cd05233 278197002615 NAD(P) binding site [chemical binding]; other site 278197002616 active site 278197002617 Predicted membrane protein [Function unknown]; Region: COG2261 278197002618 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 278197002619 dimanganese center [ion binding]; other site 278197002620 GTP-binding protein LepA; Provisional; Region: PRK05433 278197002621 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 278197002622 G1 box; other site 278197002623 putative GEF interaction site [polypeptide binding]; other site 278197002624 GTP/Mg2+ binding site [chemical binding]; other site 278197002625 Switch I region; other site 278197002626 G2 box; other site 278197002627 G3 box; other site 278197002628 Switch II region; other site 278197002629 G4 box; other site 278197002630 G5 box; other site 278197002631 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 278197002632 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 278197002633 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 278197002634 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 278197002635 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 278197002636 transmembrane helices; other site 278197002637 Peptidase family C69; Region: Peptidase_C69; pfam03577 278197002638 4-oxalocrotonate tautomerase; Provisional; Region: PRK02220 278197002639 active site 1 [active] 278197002640 dimer interface [polypeptide binding]; other site 278197002641 hexamer interface [polypeptide binding]; other site 278197002642 active site 2 [active] 278197002643 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278197002644 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 278197002645 active site 278197002646 motif I; other site 278197002647 motif II; other site 278197002648 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 278197002649 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278197002650 S-adenosylmethionine binding site [chemical binding]; other site 278197002651 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 278197002652 Beta-lactamase class A [Defense mechanisms]; Region: PenP; COG2367 278197002653 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 278197002654 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 278197002655 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 278197002656 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 278197002657 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 278197002658 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; pfam03807 278197002659 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 278197002660 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 278197002661 L-lactate oxidase; Region: L_lactate_ox; TIGR02708 278197002662 L-Lactate oxidase (LOX) FMN-binding domain. LOX is a member of the family of FMN-containing alpha-hydroxyacid oxidases and catalyzes the oxidation of l-lactate using molecular oxygen to generate pyruvate and H2O2. This family occurs in both prokaryotes...; Region: LOX_like_FMN; cd04737 278197002663 teramer interface [polypeptide binding]; other site 278197002664 active site 278197002665 FMN binding site [chemical binding]; other site 278197002666 catalytic residues [active] 278197002667 Protein of unknown function (DUF1211); Region: DUF1211; cl01421 278197002668 isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437 278197002669 Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811 278197002670 homotetramer interface [polypeptide binding]; other site 278197002671 FMN binding site [chemical binding]; other site 278197002672 homodimer contacts [polypeptide binding]; other site 278197002673 putative active site [active] 278197002674 putative substrate binding site [chemical binding]; other site 278197002675 phosphomevalonate kinase, ERG8-type, Gram-positive branch; Region: Pmev_kin_Gr_pos; TIGR01220 278197002676 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 278197002677 Mevalonate pyrophosphate decarboxylase [Lipid metabolism]; Region: MVD1; COG3407 278197002678 diphosphomevalonate decarboxylase; Region: PLN02407 278197002679 mevalonate kinase; Region: mevalon_kin; TIGR00549 278197002680 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 278197002681 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 278197002682 bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074 278197002683 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 278197002684 active site 278197002685 catalytic site [active] 278197002686 substrate binding site [chemical binding]; other site 278197002687 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 278197002688 ATP binding site [chemical binding]; other site 278197002689 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 278197002690 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5353 278197002691 Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935 278197002692 Replication initiation and membrane attachment; Region: DnaB_2; pfam07261 278197002693 Transglycosylase; Region: Transgly; pfam00912 278197002694 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 278197002695 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 278197002696 Holliday junction-specific endonuclease; Reviewed; Region: recU; PRK02234 278197002697 hypothetical protein; Provisional; Region: PRK13660 278197002698 cell division protein GpsB; Provisional; Region: PRK14127 278197002699 DivIVA domain; Region: DivI1A_domain; TIGR03544 278197002700 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 278197002701 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 278197002702 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 278197002703 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 278197002704 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 278197002705 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 278197002706 Potassium binding sites [ion binding]; other site 278197002707 Cesium cation binding sites [ion binding]; other site 278197002708 lipoprotein signal peptidase; Provisional; Region: PRK14787 278197002709 lipoprotein signal peptidase; Provisional; Region: PRK14797 278197002710 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 278197002711 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 278197002712 RNA binding surface [nucleotide binding]; other site 278197002713 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 278197002714 active site 278197002715 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 278197002716 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 278197002717 active site 278197002718 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 278197002719 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 278197002720 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 278197002721 catalytic site [active] 278197002722 subunit interface [polypeptide binding]; other site 278197002723 Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458 278197002724 ATP-grasp domain; Region: ATP-grasp_4; cl17255 278197002725 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 278197002726 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096 278197002727 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 278197002728 Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833 278197002729 Domain of unknown function (DUF814); Region: DUF814; pfam05670 278197002730 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 278197002731 MarR family; Region: MarR_2; pfam12802 278197002732 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 278197002733 EDD domain protein, DegV family; Region: DegV; TIGR00762 278197002734 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 278197002735 Integral membrane protein possibly involved in chromosome condensation [Cell division and chromosome partitioning]; Region: CrcB; COG0239 278197002736 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 278197002737 inner membrane transporter YjeM; Provisional; Region: PRK15238 278197002738 methionine sulfoxide reductase A; Provisional; Region: PRK14054 278197002739 methionine sulfoxide reductase B; Provisional; Region: PRK00222 278197002740 SelR domain; Region: SelR; pfam01641 278197002741 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 278197002742 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 278197002743 DHH family; Region: DHH; pfam01368 278197002744 DHHA2 domain; Region: DHHA2; pfam02833 278197002745 Transcriptional regulator [Transcription]; Region: LysR; COG0583 278197002746 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 278197002747 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 278197002748 dimerization interface [polypeptide binding]; other site 278197002749 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 278197002750 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 278197002751 CAP-like domain; other site 278197002752 active site 278197002753 primary dimer interface [polypeptide binding]; other site 278197002754 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 278197002755 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 278197002756 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 278197002757 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278197002758 ATP binding site [chemical binding]; other site 278197002759 Mg2+ binding site [ion binding]; other site 278197002760 G-X-G motif; other site 278197002761 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 278197002762 anchoring element; other site 278197002763 dimer interface [polypeptide binding]; other site 278197002764 ATP binding site [chemical binding]; other site 278197002765 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 278197002766 active site 278197002767 putative metal-binding site [ion binding]; other site 278197002768 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 278197002769 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 278197002770 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 278197002771 active site 278197002772 catalytic residues [active] 278197002773 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 278197002774 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278197002775 Walker A motif; other site 278197002776 ATP binding site [chemical binding]; other site 278197002777 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 278197002778 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 278197002779 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 278197002780 active site 278197002781 HslU subunit interaction site [polypeptide binding]; other site 278197002782 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 278197002783 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 278197002784 active site 278197002785 DNA binding site [nucleotide binding] 278197002786 Int/Topo IB signature motif; other site 278197002787 DNA topoisomerase I; Validated; Region: PRK05582 278197002788 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 278197002789 active site 278197002790 interdomain interaction site; other site 278197002791 putative metal-binding site [ion binding]; other site 278197002792 nucleotide binding site [chemical binding]; other site 278197002793 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 278197002794 domain I; other site 278197002795 DNA binding groove [nucleotide binding] 278197002796 phosphate binding site [ion binding]; other site 278197002797 domain II; other site 278197002798 domain III; other site 278197002799 nucleotide binding site [chemical binding]; other site 278197002800 catalytic site [active] 278197002801 domain IV; other site 278197002802 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 278197002803 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 278197002804 beta-phosphoglucomutase; Region: bPGM; TIGR01990 278197002805 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278197002806 motif II; other site 278197002807 maltose phosphorylase; Provisional; Region: PRK13807 278197002808 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 278197002809 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 278197002810 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 278197002811 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197002812 putative substrate translocation pore; other site 278197002813 Major Facilitator Superfamily; Region: MFS_1; pfam07690 278197002814 Transcriptional regulators [Transcription]; Region: PurR; COG1609 278197002815 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 278197002816 DNA binding site [nucleotide binding] 278197002817 domain linker motif; other site 278197002818 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 278197002819 DNA protecting protein DprA; Region: dprA; TIGR00732 278197002820 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 278197002821 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 278197002822 RNA/DNA hybrid binding site [nucleotide binding]; other site 278197002823 active site 278197002824 ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596 278197002825 Circularly permuted YlqF GTPase; Region: YlqF; cd01856 278197002826 GTP/Mg2+ binding site [chemical binding]; other site 278197002827 G4 box; other site 278197002828 G5 box; other site 278197002829 G1 box; other site 278197002830 Switch I region; other site 278197002831 G2 box; other site 278197002832 G3 box; other site 278197002833 Switch II region; other site 278197002834 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278197002835 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 278197002836 Walker A motif; other site 278197002837 ATP binding site [chemical binding]; other site 278197002838 Walker B motif; other site 278197002839 arginine finger; other site 278197002840 MoxR-like ATPases [General function prediction only]; Region: COG0714 278197002841 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278197002842 Walker A motif; other site 278197002843 ATP binding site [chemical binding]; other site 278197002844 Walker B motif; other site 278197002845 arginine finger; other site 278197002846 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 278197002847 Bacterial protein of unknown function (DUF916); Region: DUF916; pfam06030 278197002848 Protein of unknown function C-terminal (DUF3324); Region: DUF3324; pfam11797 278197002849 WxL domain surface cell wall-binding; Region: WxL; pfam13731 278197002850 PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014 278197002851 Haemolysin XhlA; Region: XhlA; pfam10779 278197002852 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 278197002853 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 278197002854 active site 278197002855 Bacterial SH3 domain; Region: SH3_5; pfam08460 278197002856 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 278197002857 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 278197002858 Protein of unknown function (DUF724); Region: DUF724; pfam05266 278197002859 Prophage endopeptidase tail; Region: Prophage_tail; cl12123 278197002860 Phage tail protein; Region: Sipho_tail; cl17486 278197002861 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 278197002862 Peptidase family M23; Region: Peptidase_M23; pfam01551 278197002863 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 278197002864 N-acetyl-D-glucosamine binding site [chemical binding]; other site 278197002865 catalytic residue [active] 278197002866 Protein of unknown function (DUF1268); Region: DUF1268; pfam06896 278197002867 Phage major tail protein; Region: Phage_tail; pfam04630 278197002868 Protein of unknown function (DUF806); Region: DUF806; pfam05657 278197002869 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 278197002870 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 278197002871 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 278197002872 oligomerization interface [polypeptide binding]; other site 278197002873 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 278197002874 Phage capsid family; Region: Phage_capsid; pfam05065 278197002875 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 278197002876 oligomer interface [polypeptide binding]; other site 278197002877 active site residues [active] 278197002878 Phage-related protein [Function unknown]; Region: COG4695 278197002879 Phage portal protein; Region: Phage_portal; pfam04860 278197002880 Protein of unknown function (DUF1056); Region: DUF1056; pfam06341 278197002881 Phage Terminase; Region: Terminase_1; pfam03354 278197002882 Phage terminase, small subunit; Region: Terminase_4; cl01525 278197002883 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 278197002884 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 278197002885 active site 278197002886 phage transcriptional regulator, ArpU family; Region: phage_arpU; TIGR01637 278197002887 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 278197002888 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 278197002889 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 278197002890 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278197002891 Walker A motif; other site 278197002892 ATP binding site [chemical binding]; other site 278197002893 Walker B motif; other site 278197002894 arginine finger; other site 278197002895 Conserved phage C-terminus (Phg_2220_C); Region: Phg_2220_C; pfam09524 278197002896 Protein of unknown function (DUF968); Region: DUF968; pfam06147 278197002897 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 278197002898 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 278197002899 dimer interface [polypeptide binding]; other site 278197002900 ssDNA binding site [nucleotide binding]; other site 278197002901 tetramer (dimer of dimers) interface [polypeptide binding]; other site 278197002902 ERF superfamily; Region: ERF; pfam04404 278197002903 Protein of unknown function (DUF2829); Region: DUF2829; pfam11195 278197002904 Prophage antirepressor [Transcription]; Region: COG3617 278197002905 BRO family, N-terminal domain; Region: Bro-N; smart01040 278197002906 Phage antirepressor protein KilAC domain; Region: ANT; pfam03374 278197002907 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 278197002908 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 278197002909 non-specific DNA binding site [nucleotide binding]; other site 278197002910 salt bridge; other site 278197002911 sequence-specific DNA binding site [nucleotide binding]; other site 278197002912 Domain of unknown function (DUF955); Region: DUF955; cl01076 278197002913 Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238; cl11539 278197002914 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 278197002915 phiLC3 phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial (mainly gram positive) and phage integrases, including those similar to Lactococcus...; Region: INT_phiLC3_C; cd01189 278197002916 Int/Topo IB signature motif; other site 278197002917 Mga helix-turn-helix domain; Region: Mga; pfam05043 278197002918 conserved hypothetical protein; Region: TIGR02328 278197002919 Pyrimidine dimer DNA glycosylase; Region: Pyr_excise; pfam03013 278197002920 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 278197002921 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 278197002922 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 278197002923 putative active site [active] 278197002924 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 278197002925 PTS system, beta-glucoside-specific IIABC component; Region: PTS-II-ABC-beta; TIGR01995 278197002926 active site turn [active] 278197002927 phosphorylation site [posttranslational modification] 278197002928 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 278197002929 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 278197002930 HPr interaction site; other site 278197002931 glycerol kinase (GK) interaction site [polypeptide binding]; other site 278197002932 active site 278197002933 phosphorylation site [posttranslational modification] 278197002934 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 278197002935 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 278197002936 putative active site [active] 278197002937 Predicted acyl esterases [General function prediction only]; Region: COG2936 278197002938 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 278197002939 Transcriptional regulator [Transcription]; Region: LysR; COG0583 278197002940 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 278197002941 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 278197002942 dimerization interface [polypeptide binding]; other site 278197002943 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 278197002944 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 278197002945 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 278197002946 MucBP domain; Region: MucBP; pfam06458 278197002947 MucBP domain; Region: MucBP; pfam06458 278197002948 MucBP domain; Region: MucBP; pfam06458 278197002949 MucBP domain; Region: MucBP; pfam06458 278197002950 legume lectins; Region: lectin_L-type; cl14058 278197002951 homotetramer interaction site [polypeptide binding]; other site 278197002952 homodimer interaction site [polypeptide binding]; other site 278197002953 carbohydrate binding site [chemical binding]; other site 278197002954 metal binding site [ion binding]; metal-binding site 278197002955 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 278197002956 non-specific DNA binding site [nucleotide binding]; other site 278197002957 salt bridge; other site 278197002958 sequence-specific DNA binding site [nucleotide binding]; other site 278197002959 transcriptional activator, Rgg/GadR/MutR family, C-terminal domain; Region: RGG_Cterm; TIGR01716 278197002960 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 278197002961 active site 278197002962 multimer interface [polypeptide binding]; other site 278197002963 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 278197002964 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 278197002965 Coenzyme A binding pocket [chemical binding]; other site 278197002966 amino acid transporter; Region: 2A0306; TIGR00909 278197002967 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 278197002968 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197002969 putative substrate translocation pore; other site 278197002970 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197002971 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_18; cd04677 278197002972 nudix motif; other site 278197002973 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 278197002974 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 278197002975 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 278197002976 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 278197002977 TPR motif; other site 278197002978 binding surface 278197002979 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 278197002980 binding surface 278197002981 TPR motif; other site 278197002982 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 278197002983 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 278197002984 binding surface 278197002985 TPR motif; other site 278197002986 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 278197002987 active site 278197002988 catalytic residues [active] 278197002989 Arsenate Reductase (ArsC) family, unknown subfamily; uncharacterized proteins containing a CXXC motif with similarity to thioredoxin (TRX)-fold arsenic reductases, ArsC. Proteins containing a redox active CXXC motif like TRX and glutaredoxin (GRX)...; Region: ArsC_like; cd03036 278197002990 ArsC family; Region: ArsC; pfam03960 278197002991 putative ArsC-like catalytic residues; other site 278197002992 putative TRX-like catalytic residues [active] 278197002993 Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553 278197002994 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 278197002995 C-terminal peptidase (prc); Region: prc; TIGR00225 278197002996 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 278197002997 protein binding site [polypeptide binding]; other site 278197002998 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 278197002999 Catalytic dyad [active] 278197003000 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 278197003001 hypothetical protein; Provisional; Region: PRK13672 278197003002 Uncharacterized protein conserved in bacteria (DUF2140); Region: DUF2140; pfam09911 278197003003 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_YpmR_like; cd04506 278197003004 active site 278197003005 catalytic triad [active] 278197003006 oxyanion hole [active] 278197003007 EDD domain protein, DegV family; Region: DegV; TIGR00762 278197003008 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 278197003009 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 278197003010 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 278197003011 Walker A/P-loop; other site 278197003012 ATP binding site [chemical binding]; other site 278197003013 Q-loop/lid; other site 278197003014 ABC transporter signature motif; other site 278197003015 Walker B; other site 278197003016 D-loop; other site 278197003017 H-loop/switch region; other site 278197003018 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 278197003019 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 278197003020 substrate binding pocket [chemical binding]; other site 278197003021 membrane-bound complex binding site; other site 278197003022 hinge residues; other site 278197003023 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 278197003024 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278197003025 dimer interface [polypeptide binding]; other site 278197003026 conserved gate region; other site 278197003027 putative PBP binding loops; other site 278197003028 ABC-ATPase subunit interface; other site 278197003029 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 278197003030 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 278197003031 folate binding site [chemical binding]; other site 278197003032 NADP+ binding site [chemical binding]; other site 278197003033 thymidylate synthase; Region: thym_sym; TIGR03284 278197003034 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 278197003035 dimerization interface [polypeptide binding]; other site 278197003036 active site 278197003037 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 278197003038 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 278197003039 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 278197003040 ABC transporter; Region: ABC_tran_2; pfam12848 278197003041 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 278197003042 tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13299 278197003043 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 278197003044 active site 278197003045 NTP binding site [chemical binding]; other site 278197003046 metal binding triad [ion binding]; metal-binding site 278197003047 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 278197003048 tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735 278197003049 Uncharacterized conserved protein [Function unknown]; Region: COG1284 278197003050 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 278197003051 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 278197003052 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 278197003053 Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; pfam05014 278197003054 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 278197003055 binding surface 278197003056 TPR motif; other site 278197003057 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 278197003058 TPR motif; other site 278197003059 binding surface 278197003060 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 278197003061 binding surface 278197003062 TPR motif; other site 278197003063 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 278197003064 binding surface 278197003065 TPR motif; other site 278197003066 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 278197003067 IHF dimer interface [polypeptide binding]; other site 278197003068 IHF - DNA interface [nucleotide binding]; other site 278197003069 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676 278197003070 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 278197003071 RNA binding site [nucleotide binding]; other site 278197003072 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 278197003073 RNA binding site [nucleotide binding]; other site 278197003074 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 278197003075 RNA binding site [nucleotide binding]; other site 278197003076 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 278197003077 RNA binding site [nucleotide binding]; other site 278197003078 cytidylate kinase; Provisional; Region: cmk; PRK00023 278197003079 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 278197003080 CMP-binding site; other site 278197003081 The sites determining sugar specificity; other site 278197003082 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 278197003083 DEAD-like helicases superfamily; Region: DEXDc; smart00487 278197003084 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 278197003085 ATP binding site [chemical binding]; other site 278197003086 putative Mg++ binding site [ion binding]; other site 278197003087 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 278197003088 nucleotide binding region [chemical binding]; other site 278197003089 ATP-binding site [chemical binding]; other site 278197003090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4955 278197003091 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 278197003092 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 278197003093 RNA binding surface [nucleotide binding]; other site 278197003094 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 278197003095 active site 278197003096 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 278197003097 segregation and condensation protein A; Reviewed; Region: scpA; PRK00104 278197003098 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 278197003099 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 278197003100 active site 278197003101 Int/Topo IB signature motif; other site 278197003102 Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996 278197003103 S1 domain; Region: S1_2; pfam13509 278197003104 Protein of unknown function (DUF441); Region: DUF441; pfam04284 278197003105 Protein of unknown function (DUF805); Region: DUF805; pfam05656 278197003106 pyruvate kinase; Provisional; Region: PRK06354 278197003107 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 278197003108 domain interfaces; other site 278197003109 active site 278197003110 Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848 278197003111 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 278197003112 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 278197003113 active site 278197003114 ADP/pyrophosphate binding site [chemical binding]; other site 278197003115 dimerization interface [polypeptide binding]; other site 278197003116 allosteric effector site; other site 278197003117 fructose-1,6-bisphosphate binding site; other site 278197003118 DNA polymerase III, alpha subunit [DNA replication, recombination, and repair]; Region: DnaE; COG0587 278197003119 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III; Region: PHP_PolIIIA; cd07431 278197003120 active site 278197003121 PHP Thumb interface [polypeptide binding]; other site 278197003122 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 278197003123 generic binding surface II; other site 278197003124 generic binding surface I; other site 278197003125 Protein of unknown function (DUF2929); Region: DUF2929; pfam11151 278197003126 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 278197003127 Clp amino terminal domain; Region: Clp_N; pfam02861 278197003128 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278197003129 Walker A motif; other site 278197003130 ATP binding site [chemical binding]; other site 278197003131 Walker B motif; other site 278197003132 arginine finger; other site 278197003133 Protein of unknown function (DUF2810); Region: DUF2810; cl08159 278197003134 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278197003135 Walker A motif; other site 278197003136 ATP binding site [chemical binding]; other site 278197003137 Walker B motif; other site 278197003138 arginine finger; other site 278197003139 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 278197003140 Uncharacterized conserved protein [Function unknown]; Region: COG0327 278197003141 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 278197003142 Predicted SAM-dependent methyltransferase [General function prediction only]; Region: COG2384 278197003143 Family of unknown function (DUF633); Region: DUF633; pfam04816 278197003144 RNA polymerase sigma factor RpoD; Validated; Region: PRK09210 278197003145 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 278197003146 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 278197003147 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 278197003148 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 278197003149 DNA binding residues [nucleotide binding] 278197003150 DNA primase; Validated; Region: dnaG; PRK05667 278197003151 CHC2 zinc finger; Region: zf-CHC2; pfam01807 278197003152 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 278197003153 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 278197003154 active site 278197003155 metal binding site [ion binding]; metal-binding site 278197003156 interdomain interaction site; other site 278197003157 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 278197003158 glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233 278197003159 DALR anticodon binding domain; Region: DALR_1; pfam05746 278197003160 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 278197003161 dimer interface [polypeptide binding]; other site 278197003162 motif 1; other site 278197003163 active site 278197003164 motif 2; other site 278197003165 motif 3; other site 278197003166 DNA repair protein RecO; Region: reco; TIGR00613 278197003167 Recombination protein O N terminal; Region: RecO_N; pfam11967 278197003168 Recombination protein O C terminal; Region: RecO_C; pfam02565 278197003169 GTPase Era; Reviewed; Region: era; PRK00089 278197003170 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 278197003171 G1 box; other site 278197003172 GTP/Mg2+ binding site [chemical binding]; other site 278197003173 Switch I region; other site 278197003174 G2 box; other site 278197003175 Switch II region; other site 278197003176 G3 box; other site 278197003177 G4 box; other site 278197003178 G5 box; other site 278197003179 KH domain; Region: KH_2; pfam07650 278197003180 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 278197003181 metal-binding heat shock protein; Provisional; Region: PRK00016 278197003182 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 278197003183 PhoH-like protein; Region: PhoH; pfam02562 278197003184 Yqey-like protein; Region: YqeY; pfam09424 278197003185 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 278197003186 Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618 278197003187 endonuclease IV; Provisional; Region: PRK01060 278197003188 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 278197003189 AP (apurinic/apyrimidinic) site pocket; other site 278197003190 DNA interaction; other site 278197003191 Metal-binding active site; metal-binding site 278197003192 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 278197003193 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 278197003194 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 278197003195 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 278197003196 Uncharacterized conserved protein [Function unknown]; Region: COG1284 278197003197 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 278197003198 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 278197003199 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 278197003200 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 278197003201 dimer interface [polypeptide binding]; other site 278197003202 anticodon binding site; other site 278197003203 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 278197003204 homodimer interface [polypeptide binding]; other site 278197003205 motif 1; other site 278197003206 active site 278197003207 motif 2; other site 278197003208 GAD domain; Region: GAD; pfam02938 278197003209 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 278197003210 active site 278197003211 motif 3; other site 278197003212 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 278197003213 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 278197003214 dimer interface [polypeptide binding]; other site 278197003215 motif 1; other site 278197003216 active site 278197003217 motif 2; other site 278197003218 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 278197003219 anticodon binding site; other site 278197003220 Bacterial SH3 domain homologues; Region: SH3b; smart00287 278197003221 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 278197003222 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 278197003223 active site 278197003224 metal binding site [ion binding]; metal-binding site 278197003225 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 278197003226 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278197003227 motif II; other site 278197003228 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 278197003229 putative active site [active] 278197003230 dimerization interface [polypeptide binding]; other site 278197003231 putative tRNAtyr binding site [nucleotide binding]; other site 278197003232 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 278197003233 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 278197003234 Zn2+ binding site [ion binding]; other site 278197003235 Mg2+ binding site [ion binding]; other site 278197003236 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 278197003237 synthetase active site [active] 278197003238 NTP binding site [chemical binding]; other site 278197003239 metal binding site [ion binding]; metal-binding site 278197003240 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 278197003241 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 278197003242 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 278197003243 RNA methyltransferase, RsmE family; Region: TIGR00046 278197003244 ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517 278197003245 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 278197003246 S-adenosylmethionine binding site [chemical binding]; other site 278197003247 uracil transporter; Provisional; Region: PRK10720 278197003248 EamA-like transporter family; Region: EamA; pfam00892 278197003249 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 278197003250 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 278197003251 dimer interface [polypeptide binding]; other site 278197003252 FMN binding site [chemical binding]; other site 278197003253 NADPH bind site [chemical binding]; other site 278197003254 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 278197003255 active site 278197003256 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 278197003257 DHH family; Region: DHH; pfam01368 278197003258 DHHA1 domain; Region: DHHA1; pfam02272 278197003259 Single-strand DNA-specific exonuclease, C terminal domain; Region: ssDNA-exonuc_C; pfam10141 278197003260 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 278197003261 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197003262 NAD(P) binding site [chemical binding]; other site 278197003263 active site 278197003264 ribonuclease Z; Region: RNase_Z; TIGR02651 278197003265 GTPase CgtA; Reviewed; Region: obgE; PRK12297 278197003266 GTP1/OBG; Region: GTP1_OBG; pfam01018 278197003267 Obg GTPase; Region: Obg; cd01898 278197003268 G1 box; other site 278197003269 GTP/Mg2+ binding site [chemical binding]; other site 278197003270 Switch I region; other site 278197003271 G2 box; other site 278197003272 G3 box; other site 278197003273 Switch II region; other site 278197003274 G4 box; other site 278197003275 G5 box; other site 278197003276 Domain of unknown function (DUF1967); Region: DUF1967; pfam09269 278197003277 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 278197003278 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 278197003279 GIY-YIG motif/motif A; other site 278197003280 active site 278197003281 catalytic site [active] 278197003282 putative DNA binding site [nucleotide binding]; other site 278197003283 metal binding site [ion binding]; metal-binding site 278197003284 UvrB/uvrC motif; Region: UVR; pfam02151 278197003285 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 278197003286 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 278197003287 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 278197003288 Walker A/P-loop; other site 278197003289 ATP binding site [chemical binding]; other site 278197003290 Q-loop/lid; other site 278197003291 ABC transporter signature motif; other site 278197003292 Walker B; other site 278197003293 D-loop; other site 278197003294 H-loop/switch region; other site 278197003295 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 278197003296 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 278197003297 substrate binding pocket [chemical binding]; other site 278197003298 membrane-bound complex binding site; other site 278197003299 hinge residues; other site 278197003300 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 278197003301 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278197003302 dimer interface [polypeptide binding]; other site 278197003303 conserved gate region; other site 278197003304 putative PBP binding loops; other site 278197003305 ABC-ATPase subunit interface; other site 278197003306 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u4; cd11541 278197003307 putative metal binding site [ion binding]; other site 278197003308 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 278197003309 G1 box; other site 278197003310 GTP/Mg2+ binding site [chemical binding]; other site 278197003311 Switch I region; other site 278197003312 G2 box; other site 278197003313 G3 box; other site 278197003314 Switch II region; other site 278197003315 G4 box; other site 278197003316 G5 box; other site 278197003317 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 278197003318 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 278197003319 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278197003320 Walker A motif; other site 278197003321 ATP binding site [chemical binding]; other site 278197003322 Walker B motif; other site 278197003323 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 278197003324 trigger factor; Provisional; Region: tig; PRK01490 278197003325 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 278197003326 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 278197003327 elongation factor Tu; Reviewed; Region: PRK00049 278197003328 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 278197003329 G1 box; other site 278197003330 GEF interaction site [polypeptide binding]; other site 278197003331 GTP/Mg2+ binding site [chemical binding]; other site 278197003332 Switch I region; other site 278197003333 G2 box; other site 278197003334 G3 box; other site 278197003335 Switch II region; other site 278197003336 G4 box; other site 278197003337 G5 box; other site 278197003338 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 278197003339 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 278197003340 Antibiotic Binding Site [chemical binding]; other site 278197003341 Ebola nucleoprotein; Region: Ebola_NP; pfam05505 278197003342 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 278197003343 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 278197003344 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 278197003345 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 278197003346 16S/18S rRNA binding site [nucleotide binding]; other site 278197003347 S13e-L30e interaction site [polypeptide binding]; other site 278197003348 25S rRNA binding site [nucleotide binding]; other site 278197003349 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 278197003350 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 278197003351 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 278197003352 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 278197003353 Competence protein; Region: Competence; pfam03772 278197003354 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 278197003355 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 278197003356 Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286 278197003357 catalytic motif [active] 278197003358 Zn binding site [ion binding]; other site 278197003359 SLBB domain; Region: SLBB; pfam10531 278197003360 comEA protein; Region: comE; TIGR01259 278197003361 Helix-hairpin-helix motif; Region: HHH; pfam00633 278197003362 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 278197003363 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 278197003364 active site 278197003365 (T/H)XGH motif; other site 278197003366 Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602 278197003367 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278197003368 S-adenosylmethionine binding site [chemical binding]; other site 278197003369 Uncharacterized protein conserved in bacteria (DUF2129); Region: DUF2129; pfam09902 278197003370 Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772 278197003371 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 278197003372 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 278197003373 G1 box; other site 278197003374 putative GEF interaction site [polypeptide binding]; other site 278197003375 GTP/Mg2+ binding site [chemical binding]; other site 278197003376 Switch I region; other site 278197003377 G2 box; other site 278197003378 G3 box; other site 278197003379 Switch II region; other site 278197003380 G4 box; other site 278197003381 G5 box; other site 278197003382 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 278197003383 hypothetical protein; Validated; Region: PRK07080 278197003384 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 278197003385 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 278197003386 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 278197003387 active site 278197003388 Uncharacterized protein family (UPF0223); Region: UPF0223; pfam05256 278197003389 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 278197003390 active site 278197003391 catalytic residues [active] 278197003392 metal binding site [ion binding]; metal-binding site 278197003393 Protein of unknown function (DUF1447); Region: DUF1447; pfam07288 278197003394 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 278197003395 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 278197003396 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 278197003397 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 278197003398 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 278197003399 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 278197003400 NlpC/P60 family; Region: NLPC_P60; pfam00877 278197003401 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 278197003402 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 278197003403 active site 278197003404 phosphorylation site [posttranslational modification] 278197003405 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 278197003406 active site 278197003407 P-loop; other site 278197003408 phosphorylation site [posttranslational modification] 278197003409 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 278197003410 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 278197003411 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 278197003412 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 278197003413 putative substrate binding site [chemical binding]; other site 278197003414 putative ATP binding site [chemical binding]; other site 278197003415 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 278197003416 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 278197003417 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 278197003418 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 278197003419 Domain of unknown function DUF20; Region: UPF0118; pfam01594 278197003420 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK02269 278197003421 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 278197003422 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 278197003423 active site 278197003424 helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448 278197003425 AAA domain; Region: AAA_30; pfam13604 278197003426 Family description; Region: UvrD_C_2; pfam13538 278197003427 Tetratricopeptide repeat; Region: TPR_12; pfam13424 278197003428 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 278197003429 binding surface 278197003430 TPR motif; other site 278197003431 Tetratricopeptide repeat; Region: TPR_16; pfam13432 278197003432 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 278197003433 catalytic core [active] 278197003434 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 278197003435 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 278197003436 Putative amino acid metabolism; Region: DUF1831; pfam08866 278197003437 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 278197003438 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 278197003439 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 278197003440 catalytic residue [active] 278197003441 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 278197003442 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 278197003443 dimer interface [polypeptide binding]; other site 278197003444 ADP-ribose binding site [chemical binding]; other site 278197003445 active site 278197003446 nudix motif; other site 278197003447 metal binding site [ion binding]; metal-binding site 278197003448 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 278197003449 DNA-binding site [nucleotide binding]; DNA binding site 278197003450 RNA-binding motif; other site 278197003451 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 278197003452 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 278197003453 active site 278197003454 HIGH motif; other site 278197003455 nucleotide binding site [chemical binding]; other site 278197003456 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 278197003457 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 278197003458 active site 278197003459 KMSKS motif; other site 278197003460 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 278197003461 tRNA binding surface [nucleotide binding]; other site 278197003462 anticodon binding site; other site 278197003463 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 278197003464 DivIVA protein; Region: DivIVA; pfam05103 278197003465 DivIVA domain; Region: DivI1A_domain; TIGR03544 278197003466 Uncharacterized conserved protein, contains S4-like domain [Function unknown]; Region: COG2302 278197003467 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 278197003468 RNA binding surface [nucleotide binding]; other site 278197003469 YGGT family; Region: YGGT; pfam02325 278197003470 cell division protein FtsZ; Validated; Region: PRK09330 278197003471 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 278197003472 nucleotide binding site [chemical binding]; other site 278197003473 SulA interaction site; other site 278197003474 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 278197003475 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 278197003476 nucleotide binding site [chemical binding]; other site 278197003477 SHS2 domain inserted in FTSA; Region: SHS2_FTSA; pfam02491 278197003478 Cell division protein FtsA; Region: FtsA; pfam14450 278197003479 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 278197003480 Cell division protein FtsQ; Region: FtsQ; pfam03799 278197003481 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 278197003482 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 278197003483 active site 278197003484 homodimer interface [polypeptide binding]; other site 278197003485 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472 278197003486 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 278197003487 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 278197003488 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 278197003489 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 278197003490 Mg++ binding site [ion binding]; other site 278197003491 putative catalytic motif [active] 278197003492 putative substrate binding site [chemical binding]; other site 278197003493 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 278197003494 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 278197003495 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 278197003496 PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576 278197003497 PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575 278197003498 Cell division protein FtsL; Region: FtsL; cl11433 278197003499 MraW methylase family; Region: Methyltransf_5; pfam01795 278197003500 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 278197003501 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2001 278197003502 MraZ protein; Region: MraZ; pfam02381 278197003503 MraZ protein; Region: MraZ; pfam02381 278197003504 Protein of unknown function (DUF4044); Region: DUF4044; pfam13253 278197003505 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 278197003506 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 278197003507 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 278197003508 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 278197003509 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 278197003510 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 278197003511 Domain of unknown function DUF20; Region: UPF0118; pfam01594 278197003512 PTS system glucitol/sorbitol-specific IIA component; Region: PTSIIA_gutA; cl01516 278197003513 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 278197003514 Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142 278197003515 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 278197003516 MgtE intracellular N domain; Region: MgtE_N; pfam03448 278197003517 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 278197003518 Divalent cation transporter; Region: MgtE; pfam01769 278197003519 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 278197003520 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 278197003521 active site 278197003522 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK04885 278197003523 ATP-NAD kinase; Region: NAD_kinase; pfam01513 278197003524 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 278197003525 synthetase active site [active] 278197003526 NTP binding site [chemical binding]; other site 278197003527 metal binding site [ion binding]; metal-binding site 278197003528 DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025 278197003529 catalytic residues [active] 278197003530 Competence protein CoiA-like family; Region: CoiA; cl11541 278197003531 adaptor protein; Provisional; Region: PRK02315 278197003532 Arsenate Reductase (ArsC) family, Spx subfamily; Spx is a unique RNA polymerase (RNAP)-binding protein present in bacilli and some mollicutes. It inhibits transcription by binding to the C-terminal domain of the alpha subunit of RNAP, disrupting complex...; Region: ArsC_Spx; cd03032 278197003533 ArsC family; Region: ArsC; pfam03960 278197003534 putative catalytic residues [active] 278197003535 thiol/disulfide switch; other site 278197003536 Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234 278197003537 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 278197003538 RNA binding site [nucleotide binding]; other site 278197003539 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 278197003540 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 278197003541 Protein of unknown function (DUF1461); Region: DUF1461; pfam07314 278197003542 HAD-superfamily subfamily IIA hydrolase, TIGR01457; Region: HAD-SF-IIA-hyp2 278197003543 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278197003544 active site 278197003545 motif I; other site 278197003546 motif II; other site 278197003547 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278197003548 Protein of unknown function (DUF1027); Region: DUF1027; pfam06265 278197003549 Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390 278197003550 putative active site [active] 278197003551 putative metal binding site [ion binding]; other site 278197003552 Gamma-aminobutyrate permease and related permeases [Amino acid transport and metabolism]; Region: AnsP; COG1113 278197003553 Adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0827 278197003554 Methyltransferase domain; Region: Methyltransf_26; pfam13659 278197003555 Competence protein ComGC [Intracellular trafficking and secretion]; Region: ComGC; COG4537 278197003556 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 278197003557 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 278197003558 Type II/IV secretion system protein; Region: T2SE; pfam00437 278197003559 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 278197003560 Walker A motif; other site 278197003561 ATP binding site [chemical binding]; other site 278197003562 Walker B motif; other site 278197003563 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 278197003564 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 278197003565 substrate binding site [chemical binding]; other site 278197003566 dimer interface [polypeptide binding]; other site 278197003567 ATP binding site [chemical binding]; other site 278197003568 hypothetical protein; Validated; Region: PRK00110 278197003569 DNA polymerase IV; Reviewed; Region: PRK03103 278197003570 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 278197003571 active site 278197003572 DNA binding site [nucleotide binding] 278197003573 elongation factor P; Validated; Region: PRK00529 278197003574 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 278197003575 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 278197003576 RNA binding site [nucleotide binding]; other site 278197003577 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 278197003578 RNA binding site [nucleotide binding]; other site 278197003579 Isochorismatase family; Region: Isochorismatase; pfam00857 278197003580 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 278197003581 catalytic triad [active] 278197003582 conserved cis-peptide bond; other site 278197003583 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 278197003584 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 278197003585 tetramer interface [polypeptide binding]; other site 278197003586 active site 278197003587 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 278197003588 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 278197003589 GDP-binding site [chemical binding]; other site 278197003590 ACT binding site; other site 278197003591 IMP binding site; other site 278197003592 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 278197003593 amphipathic channel; other site 278197003594 Asn-Pro-Ala signature motifs; other site 278197003595 catabolite control protein A; Region: ccpA; TIGR01481 278197003596 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 278197003597 DNA binding site [nucleotide binding] 278197003598 domain linker motif; other site 278197003599 Ligand-binding domain of the catabolite control protein A (CcpA), which functions as the major transcriptional regulator of carbon catabolite repression/regulation; Region: PBP1_CcpA_like; cd06298 278197003600 dimerization interface [polypeptide binding]; other site 278197003601 effector binding site; other site 278197003602 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 278197003603 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 278197003604 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 278197003605 active site 278197003606 pyruvate oxidase; Region: pyruv_oxi_spxB; TIGR02720 278197003607 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 278197003608 PYR/PP interface [polypeptide binding]; other site 278197003609 dimer interface [polypeptide binding]; other site 278197003610 tetramer interface [polypeptide binding]; other site 278197003611 TPP binding site [chemical binding]; other site 278197003612 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 278197003613 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 278197003614 TPP-binding site [chemical binding]; other site 278197003615 Bacterial protein of unknown function (DUF948); Region: DUF948; pfam06103 278197003616 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 278197003617 Mechanosensitive ion channel; Region: MS_channel; pfam00924 278197003618 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 278197003619 active site 278197003620 dimerization interface [polypeptide binding]; other site 278197003621 glutamate racemase; Provisional; Region: PRK00865 278197003622 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 278197003623 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 278197003624 catalytic residues [active] 278197003625 recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409 278197003626 MutS domain III; Region: MutS_III; pfam05192 278197003627 ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280 278197003628 Walker A/P-loop; other site 278197003629 ATP binding site [chemical binding]; other site 278197003630 Q-loop/lid; other site 278197003631 ABC transporter signature motif; other site 278197003632 Walker B; other site 278197003633 D-loop; other site 278197003634 H-loop/switch region; other site 278197003635 Smr domain; Region: Smr; pfam01713 278197003636 hypothetical protein; Provisional; Region: PRK13678 278197003637 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 278197003638 hypothetical protein; Provisional; Region: PRK05473 278197003639 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 278197003640 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 278197003641 motif 1; other site 278197003642 active site 278197003643 motif 2; other site 278197003644 motif 3; other site 278197003645 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 278197003646 DHHA1 domain; Region: DHHA1; pfam02272 278197003647 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 278197003648 DEAD-like helicases superfamily; Region: DEXDc; smart00487 278197003649 ATP binding site [chemical binding]; other site 278197003650 Mg++ binding site [ion binding]; other site 278197003651 motif III; other site 278197003652 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 278197003653 nucleotide binding region [chemical binding]; other site 278197003654 ATP-binding site [chemical binding]; other site 278197003655 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 278197003656 DHH family; Region: DHH; pfam01368 278197003657 DHHA1 domain; Region: DHHA1; pfam02272 278197003658 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 278197003659 active site 278197003660 DNA polymerase IV; Validated; Region: PRK02406 278197003661 DNA binding site [nucleotide binding] 278197003662 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 278197003663 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 278197003664 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 278197003665 Preprotein translocase subunit; Region: YajC; pfam02699 278197003666 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 278197003667 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 278197003668 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 278197003669 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 278197003670 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 278197003671 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278197003672 Walker A motif; other site 278197003673 ATP binding site [chemical binding]; other site 278197003674 Walker B motif; other site 278197003675 arginine finger; other site 278197003676 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 278197003677 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 278197003678 RuvA N terminal domain; Region: RuvA_N; pfam01330 278197003679 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 278197003680 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 278197003681 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278197003682 ATP binding site [chemical binding]; other site 278197003683 Mg2+ binding site [ion binding]; other site 278197003684 G-X-G motif; other site 278197003685 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 278197003686 ATP binding site [chemical binding]; other site 278197003687 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 278197003688 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 278197003689 MutS domain I; Region: MutS_I; pfam01624 278197003690 MutS domain II; Region: MutS_II; pfam05188 278197003691 MutS domain III; Region: MutS_III; pfam05192 278197003692 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 278197003693 Walker A/P-loop; other site 278197003694 ATP binding site [chemical binding]; other site 278197003695 Q-loop/lid; other site 278197003696 ABC transporter signature motif; other site 278197003697 Walker B; other site 278197003698 D-loop; other site 278197003699 H-loop/switch region; other site 278197003700 phosphodiesterase; Provisional; Region: PRK12704 278197003701 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 278197003702 Zn2+ binding site [ion binding]; other site 278197003703 Mg2+ binding site [ion binding]; other site 278197003704 recombinase A; Provisional; Region: recA; PRK09354 278197003705 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 278197003706 hexamer interface [polypeptide binding]; other site 278197003707 Walker A motif; other site 278197003708 ATP binding site [chemical binding]; other site 278197003709 Walker B motif; other site 278197003710 competence damage-inducible protein A; Provisional; Region: PRK00549 278197003711 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 278197003712 putative MPT binding site; other site 278197003713 Competence-damaged protein; Region: CinA; pfam02464 278197003714 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 278197003715 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 278197003716 non-specific DNA binding site [nucleotide binding]; other site 278197003717 salt bridge; other site 278197003718 sequence-specific DNA binding site [nucleotide binding]; other site 278197003719 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 278197003720 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197003721 NAD(P) binding site [chemical binding]; other site 278197003722 active site 278197003723 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 278197003724 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 278197003725 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 278197003726 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 278197003727 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 278197003728 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 278197003729 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 278197003730 putative active site [active] 278197003731 catalytic site [active] 278197003732 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 278197003733 putative active site [active] 278197003734 catalytic site [active] 278197003735 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 278197003736 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 278197003737 substrate binding pocket [chemical binding]; other site 278197003738 membrane-bound complex binding site; other site 278197003739 hinge residues; other site 278197003740 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 278197003741 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 278197003742 Walker A/P-loop; other site 278197003743 ATP binding site [chemical binding]; other site 278197003744 Q-loop/lid; other site 278197003745 ABC transporter signature motif; other site 278197003746 Walker B; other site 278197003747 D-loop; other site 278197003748 H-loop/switch region; other site 278197003749 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 278197003750 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278197003751 dimer interface [polypeptide binding]; other site 278197003752 conserved gate region; other site 278197003753 putative PBP binding loops; other site 278197003754 ABC-ATPase subunit interface; other site 278197003755 rod shape-determining protein MreD; Region: shape_MreD; TIGR03426 278197003756 rod shape-determining protein MreC; Provisional; Region: PRK13922 278197003757 rod shape-determining protein MreC; Region: MreC; pfam04085 278197003758 hypothetical protein; Reviewed; Region: PRK00024 278197003759 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 278197003760 MPN+ (JAMM) motif; other site 278197003761 Zinc-binding site [ion binding]; other site 278197003762 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 278197003763 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 278197003764 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 278197003765 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 278197003766 active site 278197003767 HIGH motif; other site 278197003768 nucleotide binding site [chemical binding]; other site 278197003769 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 278197003770 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 278197003771 active site 278197003772 KMSKS motif; other site 278197003773 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 278197003774 tRNA binding surface [nucleotide binding]; other site 278197003775 anticodon binding site; other site 278197003776 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 278197003777 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 278197003778 dimer interface [polypeptide binding]; other site 278197003779 catalytic triad [active] 278197003780 peroxidatic and resolving cysteines [active] 278197003781 thiamine biosynthesis protein ThiI; Provisional; Region: PRK01565 278197003782 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 278197003783 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 278197003784 Ligand Binding Site [chemical binding]; other site 278197003785 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 278197003786 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 278197003787 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 278197003788 catalytic residue [active] 278197003789 Septation ring formation regulator, EzrA; Region: EzrA; pfam06160 278197003790 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 278197003791 GAF domain; Region: GAF_2; pfam13185 278197003792 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 278197003793 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 278197003794 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 278197003795 RNA binding surface [nucleotide binding]; other site 278197003796 recombination factor protein RarA; Reviewed; Region: PRK13342 278197003797 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278197003798 Walker A motif; other site 278197003799 ATP binding site [chemical binding]; other site 278197003800 Walker B motif; other site 278197003801 arginine finger; other site 278197003802 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 278197003803 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 278197003804 Ligand Binding Site [chemical binding]; other site 278197003805 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 278197003806 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 278197003807 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 278197003808 ATP-grasp domain; Region: ATP-grasp_4; cl17255 278197003809 Protein of unknown function (DUF2785); Region: DUF2785; pfam10978 278197003810 amino acid transporter; Region: 2A0306; TIGR00909 278197003811 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 278197003812 Protein of unknown function (DUF975); Region: DUF975; cl10504 278197003813 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 278197003814 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 278197003815 Walker A/P-loop; other site 278197003816 ATP binding site [chemical binding]; other site 278197003817 Q-loop/lid; other site 278197003818 ABC transporter signature motif; other site 278197003819 Walker B; other site 278197003820 D-loop; other site 278197003821 H-loop/switch region; other site 278197003822 Predicted transcriptional regulators [Transcription]; Region: COG1725 278197003823 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278197003824 DNA-binding site [nucleotide binding]; DNA binding site 278197003825 ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464 278197003826 NLPA lipoprotein; Region: Lipoprotein_9; pfam03180 278197003827 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278197003828 dimer interface [polypeptide binding]; other site 278197003829 conserved gate region; other site 278197003830 ABC-ATPase subunit interface; other site 278197003831 ABC-type metal ion transport system, ATPase component [Inorganic ion transport and metabolism]; Region: AbcC; COG1135 278197003832 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 278197003833 Walker A/P-loop; other site 278197003834 ATP binding site [chemical binding]; other site 278197003835 Q-loop/lid; other site 278197003836 ABC transporter signature motif; other site 278197003837 Walker B; other site 278197003838 D-loop; other site 278197003839 H-loop/switch region; other site 278197003840 NIL domain; Region: NIL; pfam09383 278197003841 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 278197003842 Protein of unknown function (DUF2969); Region: DUF2969; pfam11184 278197003843 hypothetical protein; Validated; Region: PRK00041 278197003844 Protein of unknown function (DUF1146); Region: DUF1146; pfam06612 278197003845 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 278197003846 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 278197003847 gamma subunit interface [polypeptide binding]; other site 278197003848 epsilon subunit interface [polypeptide binding]; other site 278197003849 LBP interface [polypeptide binding]; other site 278197003850 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 278197003851 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 278197003852 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 278197003853 alpha subunit interaction interface [polypeptide binding]; other site 278197003854 Walker A motif; other site 278197003855 ATP binding site [chemical binding]; other site 278197003856 Walker B motif; other site 278197003857 inhibitor binding site; inhibition site 278197003858 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 278197003859 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 278197003860 core domain interface [polypeptide binding]; other site 278197003861 delta subunit interface [polypeptide binding]; other site 278197003862 epsilon subunit interface [polypeptide binding]; other site 278197003863 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 278197003864 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 278197003865 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 278197003866 beta subunit interaction interface [polypeptide binding]; other site 278197003867 Walker A motif; other site 278197003868 ATP binding site [chemical binding]; other site 278197003869 Walker B motif; other site 278197003870 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 278197003871 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 278197003872 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 278197003873 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 278197003874 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 278197003875 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 278197003876 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 278197003877 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 278197003878 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 278197003879 FtsX-like permease family; Region: FtsX; pfam02687 278197003880 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 278197003881 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 278197003882 FtsX-like permease family; Region: FtsX; pfam02687 278197003883 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 278197003884 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 278197003885 Walker A/P-loop; other site 278197003886 ATP binding site [chemical binding]; other site 278197003887 Q-loop/lid; other site 278197003888 ABC transporter signature motif; other site 278197003889 Walker B; other site 278197003890 D-loop; other site 278197003891 H-loop/switch region; other site 278197003892 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 278197003893 active site 278197003894 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 278197003895 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 278197003896 dimer interface [polypeptide binding]; other site 278197003897 active site 278197003898 glycine-pyridoxal phosphate binding site [chemical binding]; other site 278197003899 folate binding site [chemical binding]; other site 278197003900 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 278197003901 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 278197003902 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 278197003903 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278197003904 S-adenosylmethionine binding site [chemical binding]; other site 278197003905 peptide chain release factor 1; Validated; Region: prfA; PRK00591 278197003906 This domain is found in peptide chain release factors; Region: PCRF; smart00937 278197003907 RF-1 domain; Region: RF-1; pfam00472 278197003908 thymidine kinase; Provisional; Region: PRK04296 278197003909 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 278197003910 ATP binding site [chemical binding]; other site 278197003911 Walker A motif; other site 278197003912 Walker B motif; other site 278197003913 UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769 278197003914 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 278197003915 Domain of unknown function (DUF1727); Region: DUF1727; pfam08353 278197003916 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 278197003917 catalytic triad [active] 278197003918 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 278197003919 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 278197003920 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 278197003921 Beta-lactamase; Region: Beta-lactamase; pfam00144 278197003922 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 278197003923 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 278197003924 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 278197003925 Walker A/P-loop; other site 278197003926 ATP binding site [chemical binding]; other site 278197003927 Q-loop/lid; other site 278197003928 ABC transporter signature motif; other site 278197003929 Walker B; other site 278197003930 D-loop; other site 278197003931 H-loop/switch region; other site 278197003932 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 278197003933 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 278197003934 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 278197003935 Walker A/P-loop; other site 278197003936 ATP binding site [chemical binding]; other site 278197003937 Q-loop/lid; other site 278197003938 ABC transporter signature motif; other site 278197003939 Walker B; other site 278197003940 D-loop; other site 278197003941 H-loop/switch region; other site 278197003942 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278197003943 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 278197003944 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 278197003945 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 278197003946 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 278197003947 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 278197003948 active site residue [active] 278197003949 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 278197003950 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 278197003951 HicB family; Region: HicB; pfam05534 278197003952 Predicted flavoprotein [General function prediction only]; Region: COG0431 278197003953 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 278197003954 PAS domain; Region: PAS_10; pfam13596 278197003955 Predicted flavoprotein [General function prediction only]; Region: COG0431 278197003956 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 278197003957 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 278197003958 ApbE family; Region: ApbE; pfam02424 278197003959 glucose-6-phosphate isomerase; Provisional; Region: pgi; PRK14097 278197003960 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 278197003961 active site 278197003962 dimer interface [polypeptide binding]; other site 278197003963 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 278197003964 dimer interface [polypeptide binding]; other site 278197003965 active site 278197003966 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 278197003967 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 278197003968 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 278197003969 intersubunit interface [polypeptide binding]; other site 278197003970 active site 278197003971 zinc binding site [ion binding]; other site 278197003972 Na+ binding site [ion binding]; other site 278197003973 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 278197003974 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 278197003975 dimerization interface [polypeptide binding]; other site 278197003976 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 278197003977 dimer interface [polypeptide binding]; other site 278197003978 phosphorylation site [posttranslational modification] 278197003979 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278197003980 ATP binding site [chemical binding]; other site 278197003981 Mg2+ binding site [ion binding]; other site 278197003982 G-X-G motif; other site 278197003983 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 278197003984 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278197003985 active site 278197003986 phosphorylation site [posttranslational modification] 278197003987 intermolecular recognition site; other site 278197003988 dimerization interface [polypeptide binding]; other site 278197003989 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 278197003990 DNA binding site [nucleotide binding] 278197003991 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 278197003992 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 278197003993 Transglycosylase-like domain; Region: Transglycosylas; pfam06737 278197003994 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 278197003995 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 278197003996 Coenzyme A binding pocket [chemical binding]; other site 278197003997 polyribonucleotide nucleotidyltransferase; Region: polynuc_phos; TIGR03591 278197003998 Protein of unknown function (DUF1093); Region: DUF1093; pfam06486 278197003999 fructuronate transporter; Provisional; Region: PRK10034; cl15264 278197004000 Citrate transporter; Region: CitMHS; pfam03600 278197004001 gluconate kinase, FGGY type; Region: gntK_FGGY; TIGR01314 278197004002 Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770 278197004003 N- and C-terminal domain interface [polypeptide binding]; other site 278197004004 active site 278197004005 catalytic site [active] 278197004006 metal binding site [ion binding]; metal-binding site 278197004007 carbohydrate binding site [chemical binding]; other site 278197004008 ATP binding site [chemical binding]; other site 278197004009 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 278197004010 Predicted 6-phosphogluconate dehydrogenase [Carbohydrate transport and metabolism]; Region: Gnd; COG1023 278197004011 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 278197004012 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 278197004013 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 278197004014 putative active site [active] 278197004015 Mrr N-terminal domain; Region: Mrr_N; pfam14338 278197004016 Restriction endonuclease; Region: Mrr_cat; pfam04471 278197004017 Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269 278197004018 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 278197004019 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278197004020 S-adenosylmethionine binding site [chemical binding]; other site 278197004021 putative lipid kinase; Reviewed; Region: PRK13055 278197004022 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 278197004023 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 278197004024 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 278197004025 GatB domain; Region: GatB_Yqey; smart00845 278197004026 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 278197004027 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 278197004028 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 278197004029 N-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_1; cd13441 278197004030 putative dimer interface [polypeptide binding]; other site 278197004031 CamS sex pheromone cAM373 precursor; Region: CamS; pfam07537 278197004032 C-terminal repeat domain of CamS sex pheromone cAM373 precursor; Region: CamS_repeat_2; cd13440 278197004033 putative dimer interface [polypeptide binding]; other site 278197004034 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 278197004035 Part of AAA domain; Region: AAA_19; pfam13245 278197004036 Family description; Region: UvrD_C_2; pfam13538 278197004037 Phosphoribosylaminoimidazole carboxylase (NCAIR synthetase) [Nucleotide transport and metabolism]; Region: PurK; COG0026 278197004038 ATP-grasp domain; Region: ATP-grasp_4; cl17255 278197004039 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 278197004040 active site 278197004041 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 278197004042 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 278197004043 Predicted membrane protein [Function unknown]; Region: COG4684 278197004044 Phosphoglycerate Dehydrogenase, 2-hydroxyacid dehydrogenase family; Region: PGDH_1; cd12155 278197004045 putative ligand binding site [chemical binding]; other site 278197004046 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 278197004047 NAD binding site [chemical binding]; other site 278197004048 catalytic site [active] 278197004049 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_b2; cd09204 278197004050 PLD-like domain; Region: PLDc_2; pfam13091 278197004051 putative homodimer interface [polypeptide binding]; other site 278197004052 putative active site [active] 278197004053 catalytic site [active] 278197004054 DEAD-like helicases superfamily; Region: DEXDc; smart00487 278197004055 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 278197004056 ATP binding site [chemical binding]; other site 278197004057 putative Mg++ binding site [ion binding]; other site 278197004058 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 278197004059 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 278197004060 nucleotide binding region [chemical binding]; other site 278197004061 ATP-binding site [chemical binding]; other site 278197004062 Domain of unknown function (DUF3427); Region: DUF3427; pfam11907 278197004063 Ferritin-like domain; Region: Ferritin; pfam00210 278197004064 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 278197004065 dimerization interface [polypeptide binding]; other site 278197004066 DPS ferroxidase diiron center [ion binding]; other site 278197004067 ion pore; other site 278197004068 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 278197004069 non-specific DNA binding site [nucleotide binding]; other site 278197004070 salt bridge; other site 278197004071 sequence-specific DNA binding site [nucleotide binding]; other site 278197004072 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 278197004073 salt bridge; other site 278197004074 non-specific DNA binding site [nucleotide binding]; other site 278197004075 sequence-specific DNA binding site [nucleotide binding]; other site 278197004076 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 278197004077 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 278197004078 23S rRNA interface [nucleotide binding]; other site 278197004079 L3 interface [polypeptide binding]; other site 278197004080 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 278197004081 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 278197004082 dimerization interface 3.5A [polypeptide binding]; other site 278197004083 active site 278197004084 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 278197004085 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 278197004086 Q-loop/lid; other site 278197004087 ABC transporter signature motif; other site 278197004088 Walker B; other site 278197004089 D-loop; other site 278197004090 H-loop/switch region; other site 278197004091 cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13635 278197004092 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 278197004093 Walker A/P-loop; other site 278197004094 ATP binding site [chemical binding]; other site 278197004095 Q-loop/lid; other site 278197004096 ABC transporter signature motif; other site 278197004097 Walker B; other site 278197004098 D-loop; other site 278197004099 H-loop/switch region; other site 278197004100 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 278197004101 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 278197004102 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 278197004103 alphaNTD homodimer interface [polypeptide binding]; other site 278197004104 alphaNTD - beta interaction site [polypeptide binding]; other site 278197004105 alphaNTD - beta' interaction site [polypeptide binding]; other site 278197004106 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 278197004107 30S ribosomal protein S11; Validated; Region: PRK05309 278197004108 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 278197004109 30S ribosomal protein S13; Region: bact_S13; TIGR03631 278197004110 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 278197004111 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 278197004112 rRNA binding site [nucleotide binding]; other site 278197004113 predicted 30S ribosome binding site; other site 278197004114 adenylate kinase; Reviewed; Region: adk; PRK00279 278197004115 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 278197004116 AMP-binding site [chemical binding]; other site 278197004117 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 278197004118 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 278197004119 SecY translocase; Region: SecY; pfam00344 278197004120 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 278197004121 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 278197004122 23S rRNA binding site [nucleotide binding]; other site 278197004123 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 278197004124 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 278197004125 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 278197004126 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 278197004127 5S rRNA interface [nucleotide binding]; other site 278197004128 L27 interface [polypeptide binding]; other site 278197004129 23S rRNA interface [nucleotide binding]; other site 278197004130 L5 interface [polypeptide binding]; other site 278197004131 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 278197004132 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 278197004133 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 278197004134 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 278197004135 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 278197004136 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 278197004137 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 278197004138 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 278197004139 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 278197004140 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 278197004141 RNA binding site [nucleotide binding]; other site 278197004142 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 278197004143 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 278197004144 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 278197004145 23S rRNA interface [nucleotide binding]; other site 278197004146 putative translocon interaction site; other site 278197004147 signal recognition particle (SRP54) interaction site; other site 278197004148 L23 interface [polypeptide binding]; other site 278197004149 trigger factor interaction site; other site 278197004150 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 278197004151 23S rRNA interface [nucleotide binding]; other site 278197004152 5S rRNA interface [nucleotide binding]; other site 278197004153 putative antibiotic binding site [chemical binding]; other site 278197004154 L25 interface [polypeptide binding]; other site 278197004155 L27 interface [polypeptide binding]; other site 278197004156 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 278197004157 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 278197004158 G-X-X-G motif; other site 278197004159 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 278197004160 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 278197004161 putative translocon binding site; other site 278197004162 protein-rRNA interface [nucleotide binding]; other site 278197004163 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 278197004164 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 278197004165 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 278197004166 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 278197004167 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 278197004168 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 278197004169 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 278197004170 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 278197004171 elongation factor G; Reviewed; Region: PRK12739 278197004172 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 278197004173 G1 box; other site 278197004174 putative GEF interaction site [polypeptide binding]; other site 278197004175 GTP/Mg2+ binding site [chemical binding]; other site 278197004176 Switch I region; other site 278197004177 G2 box; other site 278197004178 G3 box; other site 278197004179 Switch II region; other site 278197004180 G4 box; other site 278197004181 G5 box; other site 278197004182 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 278197004183 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 278197004184 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 278197004185 30S ribosomal protein S7; Validated; Region: PRK05302 278197004186 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 278197004187 S17 interaction site [polypeptide binding]; other site 278197004188 S8 interaction site; other site 278197004189 16S rRNA interaction site [nucleotide binding]; other site 278197004190 streptomycin interaction site [chemical binding]; other site 278197004191 23S rRNA interaction site [nucleotide binding]; other site 278197004192 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 278197004193 nuc_hydro_ TvIAG: Nucleoside hydrolases similar to the Inosine-adenosine-guanosine-preferring nucleoside hydrolase from Trypanosoma vivax. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base; Region: nuc_hydro_TvIAG; cd02647 278197004194 active site 278197004195 dimerization interface [polypeptide binding]; other site 278197004196 DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566 278197004197 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 278197004198 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 278197004199 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 278197004200 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 278197004201 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 278197004202 cleft; other site 278197004203 Rpb1 - Rpb5 interaction site [polypeptide binding]; other site 278197004204 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 278197004205 DNA binding site [nucleotide binding] 278197004206 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 278197004207 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 278197004208 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 278197004209 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 278197004210 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 278197004211 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 278197004212 RPB1 interaction site [polypeptide binding]; other site 278197004213 RPB10 interaction site [polypeptide binding]; other site 278197004214 RPB11 interaction site [polypeptide binding]; other site 278197004215 RPB3 interaction site [polypeptide binding]; other site 278197004216 RPB12 interaction site [polypeptide binding]; other site 278197004217 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 278197004218 Clp amino terminal domain; Region: Clp_N; pfam02861 278197004219 Clp amino terminal domain; Region: Clp_N; pfam02861 278197004220 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278197004221 Walker A motif; other site 278197004222 ATP binding site [chemical binding]; other site 278197004223 Walker B motif; other site 278197004224 arginine finger; other site 278197004225 UvrB/uvrC motif; Region: UVR; pfam02151 278197004226 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278197004227 Walker A motif; other site 278197004228 ATP binding site [chemical binding]; other site 278197004229 Walker B motif; other site 278197004230 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 278197004231 Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848 278197004232 seryl-tRNA synthetase; Provisional; Region: PRK05431 278197004233 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 278197004234 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 278197004235 dimer interface [polypeptide binding]; other site 278197004236 active site 278197004237 motif 1; other site 278197004238 motif 2; other site 278197004239 motif 3; other site 278197004240 Deoxynucleoside kinases [Nucleotide transport and metabolism]; Region: COG1428 278197004241 Deoxyribonucleoside kinase (dNK) catalyzes the phosphorylation of deoxyribonucleosides to yield corresponding monophosphates (dNMPs). This family consists of various deoxynucleoside kinases including deoxyribo- cytidine (EC 2.7.1.74), guanosine (EC 2.7.1; Region: dNK; cd01673 278197004242 Substrate-binding site [chemical binding]; other site 278197004243 Substrate specificity [chemical binding]; other site 278197004244 lysine transporter; Provisional; Region: PRK10836 278197004245 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 278197004246 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 278197004247 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 278197004248 Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581 278197004249 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 278197004250 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 278197004251 nucleotide binding site [chemical binding]; other site 278197004252 Protein of unknown function (DUF3815); Region: DUF3815; pfam12821 278197004253 Uncharacterized conserved protein [Function unknown]; Region: COG2966 278197004254 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 278197004255 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 278197004256 DNA-binding site [nucleotide binding]; DNA binding site 278197004257 RNA-binding motif; other site 278197004258 PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392 278197004259 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 278197004260 active site 278197004261 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 278197004262 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 278197004263 Zn2+ binding site [ion binding]; other site 278197004264 Mg2+ binding site [ion binding]; other site 278197004265 phosphodiesterase; Provisional; Region: PRK12704 278197004266 KH domain; Region: KH_1; pfam00013 278197004267 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 278197004268 Zn2+ binding site [ion binding]; other site 278197004269 Mg2+ binding site [ion binding]; other site 278197004270 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 278197004271 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 278197004272 active site 278197004273 xanthine permease; Region: pbuX; TIGR03173 278197004274 Peptidase family C69; Region: Peptidase_C69; pfam03577 278197004275 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 278197004276 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 278197004277 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 278197004278 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 278197004279 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 278197004280 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 278197004281 purine monophosphate binding site [chemical binding]; other site 278197004282 dimer interface [polypeptide binding]; other site 278197004283 putative catalytic residues [active] 278197004284 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 278197004285 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 278197004286 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 278197004287 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 278197004288 active site 278197004289 substrate binding site [chemical binding]; other site 278197004290 cosubstrate binding site; other site 278197004291 catalytic site [active] 278197004292 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 278197004293 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 278197004294 dimerization interface [polypeptide binding]; other site 278197004295 putative ATP binding site [chemical binding]; other site 278197004296 amidophosphoribosyltransferase; Provisional; Region: PRK07272 278197004297 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 278197004298 active site 278197004299 tetramer interface [polypeptide binding]; other site 278197004300 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 278197004301 active site 278197004302 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 278197004303 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 278197004304 dimerization interface [polypeptide binding]; other site 278197004305 ATP binding site [chemical binding]; other site 278197004306 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 278197004307 dimerization interface [polypeptide binding]; other site 278197004308 ATP binding site [chemical binding]; other site 278197004309 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 278197004310 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 278197004311 putative active site [active] 278197004312 catalytic triad [active] 278197004313 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 278197004314 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 278197004315 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 278197004316 ATP binding site [chemical binding]; other site 278197004317 active site 278197004318 substrate binding site [chemical binding]; other site 278197004319 phosphoribosylaminoimidazole carboxylase, PurK protein; Region: purK; TIGR01161 278197004320 ATP-grasp domain; Region: ATP-grasp; pfam02222 278197004321 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 278197004322 AIR carboxylase; Region: AIRC; pfam00731 278197004323 Nicotinamidase_ related amidohydrolases. Cysteine hydrolases of unknown function that share the catalytic triad with other amidohydrolases, like nicotinamidase, which converts nicotinamide to nicotinic acid and ammonia; Region: nicotinamidase_related; cd01014 278197004324 Isochorismatase family; Region: Isochorismatase; pfam00857 278197004325 catalytic triad [active] 278197004326 conserved cis-peptide bond; other site 278197004327 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 278197004328 dimer interface [polypeptide binding]; other site 278197004329 active site 278197004330 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 278197004331 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 278197004332 CoA binding domain; Region: CoA_binding; pfam02629 278197004333 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 278197004334 Beta-lactamase; Region: Beta-lactamase; pfam00144 278197004335 UGMP family protein; Validated; Region: PRK09604 278197004336 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 278197004337 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 278197004338 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 278197004339 Coenzyme A binding pocket [chemical binding]; other site 278197004340 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 278197004341 Glycoprotease family; Region: Peptidase_M22; pfam00814 278197004342 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 278197004343 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 278197004344 NAD binding site [chemical binding]; other site 278197004345 homodimer interface [polypeptide binding]; other site 278197004346 active site 278197004347 substrate binding site [chemical binding]; other site 278197004348 Acyl-ACP thioesterase; Region: Acyl-ACP_TE; pfam01643 278197004349 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 278197004350 active site 278197004351 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 278197004352 active site 2 [active] 278197004353 Predicted methyltransferases [General function prediction only]; Region: COG0313 278197004354 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 278197004355 putative SAM binding site [chemical binding]; other site 278197004356 putative homodimer interface [polypeptide binding]; other site 278197004357 Protein of unknown function (DUF972); Region: DUF972; pfam06156 278197004358 DNA polymerase III subunit delta'; Validated; Region: PRK08058 278197004359 DNA polymerase III subunit delta'; Validated; Region: PRK08485 278197004360 Protein of unknown function (DUF970); Region: DUF970; pfam06153 278197004361 thymidylate kinase; Validated; Region: tmk; PRK00698 278197004362 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 278197004363 TMP-binding site; other site 278197004364 ATP-binding site [chemical binding]; other site 278197004365 recombination protein RecR; Reviewed; Region: recR; PRK00076 278197004366 RecR protein; Region: RecR; pfam02132 278197004367 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 278197004368 putative active site [active] 278197004369 putative metal-binding site [ion binding]; other site 278197004370 tetramer interface [polypeptide binding]; other site 278197004371 hypothetical protein; Validated; Region: PRK00153 278197004372 DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563 278197004373 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278197004374 Walker A motif; other site 278197004375 ATP binding site [chemical binding]; other site 278197004376 Walker B motif; other site 278197004377 arginine finger; other site 278197004378 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 278197004379 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 278197004380 nucleoside/Zn binding site; other site 278197004381 dimer interface [polypeptide binding]; other site 278197004382 catalytic motif [active] 278197004383 Methyltransferase domain; Region: Methyltransf_31; pfam13847 278197004384 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278197004385 S-adenosylmethionine binding site [chemical binding]; other site 278197004386 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 278197004387 catalytic residues [active] 278197004388 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07306 278197004389 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 278197004390 Class I ribonucleotide reductase; Region: RNR_I; cd01679 278197004391 active site 278197004392 dimer interface [polypeptide binding]; other site 278197004393 catalytic residues [active] 278197004394 effector binding site; other site 278197004395 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 278197004396 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 278197004397 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 278197004398 dimer interface [polypeptide binding]; other site 278197004399 putative radical transfer pathway; other site 278197004400 diiron center [ion binding]; other site 278197004401 tyrosyl radical; other site 278197004402 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 278197004403 core dimer interface [polypeptide binding]; other site 278197004404 peripheral dimer interface [polypeptide binding]; other site 278197004405 L10 interface [polypeptide binding]; other site 278197004406 L11 interface [polypeptide binding]; other site 278197004407 putative EF-Tu interaction site [polypeptide binding]; other site 278197004408 putative EF-G interaction site [polypeptide binding]; other site 278197004409 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 278197004410 23S rRNA interface [nucleotide binding]; other site 278197004411 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 278197004412 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 278197004413 mRNA/rRNA interface [nucleotide binding]; other site 278197004414 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 278197004415 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 278197004416 23S rRNA interface [nucleotide binding]; other site 278197004417 L7/L12 interface [polypeptide binding]; other site 278197004418 putative thiostrepton binding site; other site 278197004419 L25 interface [polypeptide binding]; other site 278197004420 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 278197004421 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 278197004422 putative homodimer interface [polypeptide binding]; other site 278197004423 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 278197004424 heterodimer interface [polypeptide binding]; other site 278197004425 homodimer interface [polypeptide binding]; other site 278197004426 preprotein translocase, SecE subunit, bacterial; Region: secE_bact; TIGR00964 278197004427 50S ribosomal protein L33; Validated; Region: rpmG; PRK00504 278197004428 RNA polymerase factor sigma-70; Validated; Region: PRK08295 278197004429 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 278197004430 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 278197004431 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 278197004432 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 278197004433 dimerization interface [polypeptide binding]; other site 278197004434 active site 278197004435 metal binding site [ion binding]; metal-binding site 278197004436 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 278197004437 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 278197004438 active site 278197004439 HIGH motif; other site 278197004440 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 278197004441 KMSKS motif; other site 278197004442 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 278197004443 tRNA binding surface [nucleotide binding]; other site 278197004444 anticodon binding site; other site 278197004445 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 278197004446 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 278197004447 active site 278197004448 HIGH motif; other site 278197004449 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 278197004450 active site 278197004451 KMSKS motif; other site 278197004452 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 278197004453 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 278197004454 putative active site [active] 278197004455 DNA repair protein RadA; Provisional; Region: PRK11823 278197004456 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 278197004457 Walker A motif/ATP binding site; other site 278197004458 ATP binding site [chemical binding]; other site 278197004459 Walker B motif; other site 278197004460 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 278197004461 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 278197004462 trimer interface [polypeptide binding]; other site 278197004463 active site 278197004464 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 278197004465 Coenzyme A binding pocket [chemical binding]; other site 278197004466 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 278197004467 tetramer (dimer of dimers) interface [polypeptide binding]; other site 278197004468 active site 278197004469 dimer interface [polypeptide binding]; other site 278197004470 Peptidase C1B subfamily (MEROPS database nomenclature); composed of eukaryotic bleomycin hydrolases (BH) and bacterial aminopeptidases C (pepC). The proteins of this subfamily contain a large insert relative to the C1A peptidase (papain) subfamily. BH is...; Region: Peptidase_C1B; cd00585 278197004471 trimer interface [polypeptide binding]; other site 278197004472 active site 278197004473 G bulge; other site 278197004474 Predicted transcriptional regulators [Transcription]; Region: COG1733 278197004475 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 278197004476 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197004477 putative substrate translocation pore; other site 278197004478 Major Facilitator Superfamily; Region: MFS_1; pfam07690 278197004479 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 278197004480 catalytic core [active] 278197004481 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 278197004482 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 278197004483 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 278197004484 dimer interface [polypeptide binding]; other site 278197004485 active site 278197004486 CoA binding pocket [chemical binding]; other site 278197004487 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 278197004488 active site 278197004489 phosphorylation site [posttranslational modification] 278197004490 Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221 278197004491 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278197004492 Walker A motif; other site 278197004493 ATP binding site [chemical binding]; other site 278197004494 Walker B motif; other site 278197004495 arginine finger; other site 278197004496 Transcriptional antiterminator [Transcription]; Region: COG3933 278197004497 PRD domain; Region: PRD; pfam00874 278197004498 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 278197004499 active pocket/dimerization site; other site 278197004500 active site 278197004501 phosphorylation site [posttranslational modification] 278197004502 Domain of unknown function (DUF956); Region: DUF956; pfam06115 278197004503 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 278197004504 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 278197004505 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 278197004506 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 278197004507 active pocket/dimerization site; other site 278197004508 active site 278197004509 phosphorylation site [posttranslational modification] 278197004510 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 278197004511 active site 278197004512 phosphorylation site [posttranslational modification] 278197004513 hypothetical protein; Provisional; Region: PRK04351 278197004514 SprT homologues; Region: SprT; cl01182 278197004515 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 278197004516 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 278197004517 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 278197004518 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 278197004519 RNA binding site [nucleotide binding]; other site 278197004520 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 278197004521 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 278197004522 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 278197004523 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 278197004524 Soluble P-type ATPase [General function prediction only]; Region: COG4087 278197004525 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 278197004526 NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171 278197004527 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 278197004528 homodimer interface [polypeptide binding]; other site 278197004529 NAD binding pocket [chemical binding]; other site 278197004530 ATP binding pocket [chemical binding]; other site 278197004531 Mg binding site [ion binding]; other site 278197004532 active-site loop [active] 278197004533 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 278197004534 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 278197004535 active site 278197004536 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 278197004537 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 278197004538 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 278197004539 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278197004540 DNA-binding site [nucleotide binding]; DNA binding site 278197004541 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 278197004542 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 278197004543 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 278197004544 active site 278197004545 dimer interface [polypeptide binding]; other site 278197004546 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 278197004547 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 278197004548 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 278197004549 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 278197004550 active site 278197004551 metal binding site [ion binding]; metal-binding site 278197004552 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 278197004553 RibD C-terminal domain; Region: RibD_C; cl17279 278197004554 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 278197004555 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 278197004556 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197004557 putative substrate translocation pore; other site 278197004558 POT family; Region: PTR2; cl17359 278197004559 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 278197004560 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 278197004561 dimer interface [polypeptide binding]; other site 278197004562 putative anticodon binding site; other site 278197004563 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 278197004564 motif 1; other site 278197004565 active site 278197004566 motif 2; other site 278197004567 motif 3; other site 278197004568 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 278197004569 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 278197004570 FMN binding site [chemical binding]; other site 278197004571 active site 278197004572 catalytic residues [active] 278197004573 substrate binding site [chemical binding]; other site 278197004574 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 278197004575 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 278197004576 dimerization interface [polypeptide binding]; other site 278197004577 domain crossover interface; other site 278197004578 redox-dependent activation switch; other site 278197004579 FtsH Extracellular; Region: FtsH_ext; pfam06480 278197004580 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 278197004581 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 278197004582 Walker A motif; other site 278197004583 ATP binding site [chemical binding]; other site 278197004584 Walker B motif; other site 278197004585 arginine finger; other site 278197004586 Peptidase family M41; Region: Peptidase_M41; pfam01434 278197004587 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 278197004588 active site 278197004589 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 278197004590 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 278197004591 Ligand Binding Site [chemical binding]; other site 278197004592 TilS substrate C-terminal domain; Region: TilS_C; smart00977 278197004593 hypothetical protein; Provisional; Region: PRK08582 278197004594 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 278197004595 RNA binding site [nucleotide binding]; other site 278197004596 Septum formation initiator; Region: DivIC; pfam04977 278197004597 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 278197004598 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 278197004599 RNA binding surface [nucleotide binding]; other site 278197004600 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 278197004601 Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124 278197004602 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 278197004603 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 278197004604 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 278197004605 ATP binding site [chemical binding]; other site 278197004606 putative Mg++ binding site [ion binding]; other site 278197004607 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 278197004608 nucleotide binding region [chemical binding]; other site 278197004609 ATP-binding site [chemical binding]; other site 278197004610 TRCF domain; Region: TRCF; pfam03461 278197004611 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 278197004612 putative active site [active] 278197004613 catalytic residue [active] 278197004614 L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066 278197004615 L-2-hydroxyisocapronate dehydrogenases and some bacterial L-lactate dehydrogenases; Region: HicDH_like; cd05291 278197004616 tetramer (dimer of dimers) interface [polypeptide binding]; other site 278197004617 NAD binding site [chemical binding]; other site 278197004618 dimer interface [polypeptide binding]; other site 278197004619 substrate binding site [chemical binding]; other site 278197004620 Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229 278197004621 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 278197004622 FOG: CBS domain [General function prediction only]; Region: COG0517 278197004623 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 278197004624 PemK-like protein; Region: PemK; pfam02452 278197004625 alanine racemase; Reviewed; Region: alr; PRK00053 278197004626 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 278197004627 active site 278197004628 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 278197004629 dimer interface [polypeptide binding]; other site 278197004630 substrate binding site [chemical binding]; other site 278197004631 catalytic residues [active] 278197004632 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 278197004633 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 278197004634 DEAD-like helicases superfamily; Region: DEXDc; smart00487 278197004635 ATP binding site [chemical binding]; other site 278197004636 Mg++ binding site [ion binding]; other site 278197004637 motif III; other site 278197004638 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 278197004639 nucleotide binding region [chemical binding]; other site 278197004640 ATP-binding site [chemical binding]; other site 278197004641 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 278197004642 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 278197004643 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 278197004644 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 278197004645 heat shock protein HtpX; Provisional; Region: PRK04897 278197004646 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 278197004647 Sortase A (SrtA) or subfamily-1 sortases are cysteine transpeptidases found in gram-positive bacteria that anchor surface proteins to peptidoglycans of the bacterial cell wall envelope. They do so by catalyzing a transpeptidation reaction in which the...; Region: Sortase_A_1; cd06165 278197004648 active site 278197004649 catalytic site [active] 278197004650 drug efflux system protein MdtG; Provisional; Region: PRK09874 278197004651 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197004652 putative substrate translocation pore; other site 278197004653 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 278197004654 transcription termination factor Rho; Provisional; Region: rho; PRK09376 278197004655 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 278197004656 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 278197004657 RNA binding site [nucleotide binding]; other site 278197004658 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 278197004659 multimer interface [polypeptide binding]; other site 278197004660 Walker A motif; other site 278197004661 ATP binding site [chemical binding]; other site 278197004662 Walker B motif; other site 278197004663 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 278197004664 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 278197004665 hinge; other site 278197004666 active site 278197004667 CTP synthetase; Validated; Region: pyrG; PRK05380 278197004668 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 278197004669 Catalytic site [active] 278197004670 active site 278197004671 UTP binding site [chemical binding]; other site 278197004672 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 278197004673 active site 278197004674 putative oxyanion hole; other site 278197004675 catalytic triad [active] 278197004676 DNA-directed RNA polymerase delta subunit; Region: RNA_pol_delta; pfam05066 278197004677 Domain of unknown function (DUF1934); Region: DUF1934; pfam09148 278197004678 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 278197004679 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 278197004680 Zn2+ binding site [ion binding]; other site 278197004681 Mg2+ binding site [ion binding]; other site 278197004682 sugar phosphate phosphatase; Provisional; Region: PRK10513 278197004683 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278197004684 active site 278197004685 motif I; other site 278197004686 motif II; other site 278197004687 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278197004688 Domain of unknown function (DUF3899); Region: DUF3899; pfam13038 278197004689 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 278197004690 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 278197004691 nucleotide binding site [chemical binding]; other site 278197004692 butyrate kinase; Region: butyr_kinase; TIGR02707 278197004693 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 278197004694 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Bacillus subtilis yoeA; Region: MATE_yoeA_like; cd13138 278197004695 CAAX protease self-immunity; Region: Abi; pfam02517 278197004696 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 278197004697 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278197004698 motif II; other site 278197004699 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 278197004700 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 278197004701 peptide binding site [polypeptide binding]; other site 278197004702 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 278197004703 Uncharacterized conserved protein [Function unknown]; Region: COG1284 278197004704 Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588 278197004705 Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035 278197004706 D-alanyl-lipoteichoic acid biosynthesis protein DltD; Region: LTA_DltD; TIGR04092 278197004707 DltD N-terminal region; Region: DltD_N; pfam04915 278197004708 DltD central region; Region: DltD_M; pfam04918 278197004709 DltD C-terminal region; Region: DltD_C; pfam04914 278197004710 D-alanine--poly(phosphoribitol) ligase subunit 2; Validated; Region: PRK05087 278197004711 D-alanyl-lipoteichoic acid biosynthesis protein DltB; Region: LTA_dltB; TIGR04091 278197004712 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 278197004713 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 278197004714 acyl-activating enzyme (AAE) consensus motif; other site 278197004715 AMP binding site [chemical binding]; other site 278197004716 D-Ala-teichoic acid biosynthesis protein; Region: DUF3687; pfam12459 278197004717 BioY family; Region: BioY; pfam02632 278197004718 Predicted membrane protein [Function unknown]; Region: COG3601 278197004719 Protein of unknown function (DUF3816); Region: DUF3816; pfam12822 278197004720 Helix-Turn-Helix DNA binding domain of GlnR-like transcription regulators; Region: HTH_GlnR-like; cd01105 278197004721 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 278197004722 DNA binding residues [nucleotide binding] 278197004723 putative dimer interface [polypeptide binding]; other site 278197004724 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 278197004725 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197004726 putative substrate translocation pore; other site 278197004727 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197004728 Domain of unknown function (DUF4091); Region: DUF4091; pfam13320 278197004729 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 278197004730 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 278197004731 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 278197004732 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 278197004733 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 278197004734 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 278197004735 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 278197004736 nucleotide binding site [chemical binding]; other site 278197004737 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 278197004738 beta-galactosidase; Region: BGL; TIGR03356 278197004739 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 278197004740 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 278197004741 Beta-lactamase; Region: Beta-lactamase; pfam00144 278197004742 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 278197004743 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 278197004744 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 278197004745 Walker A/P-loop; other site 278197004746 ATP binding site [chemical binding]; other site 278197004747 Q-loop/lid; other site 278197004748 ABC transporter signature motif; other site 278197004749 Walker B; other site 278197004750 D-loop; other site 278197004751 H-loop/switch region; other site 278197004752 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 278197004753 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 278197004754 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 278197004755 active site 278197004756 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 278197004757 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 278197004758 Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887 278197004759 CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464 278197004760 6-pyruvoyl-tetrahydropterin synthase related domain; membrane protein; Region: PTPS_related; pfam10131 278197004761 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 278197004762 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 278197004763 Ligand binding site; other site 278197004764 Putative Catalytic site; other site 278197004765 DXD motif; other site 278197004766 Predicted membrane protein [Function unknown]; Region: COG2246 278197004767 GtrA-like protein; Region: GtrA; pfam04138 278197004768 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 278197004769 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 278197004770 nucleotide binding pocket [chemical binding]; other site 278197004771 K-X-D-G motif; other site 278197004772 catalytic site [active] 278197004773 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 278197004774 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 278197004775 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 278197004776 Dimer interface [polypeptide binding]; other site 278197004777 Human Ape1-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: Ape1-like_AP-endo; cd09087 278197004778 active site 278197004779 putative catalytic site [active] 278197004780 DNA binding site [nucleotide binding] 278197004781 putative phosphate binding site [ion binding]; other site 278197004782 metal binding site A [ion binding]; metal-binding site 278197004783 AP binding site [nucleotide binding]; other site 278197004784 metal binding site B [ion binding]; metal-binding site 278197004785 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 278197004786 substrate binding site [chemical binding]; other site 278197004787 Membrane transport protein; Region: Mem_trans; cl09117 278197004788 malate dehydrogenase; Provisional; Region: PRK13529 278197004789 Malic enzyme, N-terminal domain; Region: malic; pfam00390 278197004790 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 278197004791 NAD(P) binding site [chemical binding]; other site 278197004792 Transcriptional regulator [Transcription]; Region: LysR; COG0583 278197004793 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 278197004794 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 278197004795 dimerization interface [polypeptide binding]; other site 278197004796 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 278197004797 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 278197004798 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 278197004799 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 278197004800 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 278197004801 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 278197004802 active site 278197004803 catalytic tetrad [active] 278197004804 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 278197004805 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278197004806 motif II; other site 278197004807 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 278197004808 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 278197004809 Cl- selectivity filter; other site 278197004810 Cl- binding residues [ion binding]; other site 278197004811 pore gating glutamate residue; other site 278197004812 dimer interface [polypeptide binding]; other site 278197004813 H+/Cl- coupling transport residue; other site 278197004814 TrkA-C domain; Region: TrkA_C; pfam02080 278197004815 glycerol kinase; Provisional; Region: glpK; PRK00047 278197004816 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 278197004817 N- and C-terminal domain interface [polypeptide binding]; other site 278197004818 active site 278197004819 MgATP binding site [chemical binding]; other site 278197004820 catalytic site [active] 278197004821 metal binding site [ion binding]; metal-binding site 278197004822 glycerol binding site [chemical binding]; other site 278197004823 homotetramer interface [polypeptide binding]; other site 278197004824 homodimer interface [polypeptide binding]; other site 278197004825 FBP binding site [chemical binding]; other site 278197004826 protein IIAGlc interface [polypeptide binding]; other site 278197004827 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 278197004828 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 278197004829 amphipathic channel; other site 278197004830 Asn-Pro-Ala signature motifs; other site 278197004831 Predicted membrane protein [Function unknown]; Region: COG1288 278197004832 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 278197004833 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 278197004834 arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810 278197004835 arginine deiminase; Provisional; Region: PRK01388 278197004836 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 278197004837 carbamate kinase; Reviewed; Region: PRK12686 278197004838 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 278197004839 putative substrate binding site [chemical binding]; other site 278197004840 nucleotide binding site [chemical binding]; other site 278197004841 nucleotide binding site [chemical binding]; other site 278197004842 homodimer interface [polypeptide binding]; other site 278197004843 ornithine carbamoyltransferase; Provisional; Region: PRK04284 278197004844 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 278197004845 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 278197004846 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 278197004847 Response regulator receiver domain; Region: Response_reg; pfam00072 278197004848 active site 278197004849 phosphorylation site [posttranslational modification] 278197004850 intermolecular recognition site; other site 278197004851 dimerization interface [polypeptide binding]; other site 278197004852 YcbB domain; Region: YcbB; pfam08664 278197004853 oligoendopeptidase F; Region: pepF; TIGR00181 278197004854 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 278197004855 active site 278197004856 Zn binding site [ion binding]; other site 278197004857 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197004858 Major Facilitator Superfamily; Region: MFS_1; pfam07690 278197004859 putative substrate translocation pore; other site 278197004860 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 278197004861 Biotin operon repressor [Transcription]; Region: BirA; COG1654 278197004862 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 278197004863 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 278197004864 BioY family; Region: BioY; pfam02632 278197004865 S-ribosylhomocysteinase; Provisional; Region: PRK02260 278197004866 BCCT family transporter; Region: BCCT; pfam02028 278197004867 maltose O-acetyltransferase; Provisional; Region: PRK10092 278197004868 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 278197004869 active site 278197004870 substrate binding site [chemical binding]; other site 278197004871 trimer interface [polypeptide binding]; other site 278197004872 CoA binding site [chemical binding]; other site 278197004873 coenzyme A disulfide reductase; Reviewed; Region: PRK09564 278197004874 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 278197004875 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 278197004876 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 278197004877 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 278197004878 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 278197004879 Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471 278197004880 putative dimer interface [polypeptide binding]; other site 278197004881 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 278197004882 active site 278197004883 multimer interface [polypeptide binding]; other site 278197004884 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 278197004885 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 278197004886 Soluble P-type ATPase [General function prediction only]; Region: COG4087 278197004887 copper transport repressor, CopY/TcrY family; Region: CopY_TcrY; TIGR02698 278197004888 Penicillinase repressor; Region: Pencillinase_R; pfam03965 278197004889 EamA-like transporter family; Region: EamA; pfam00892 278197004890 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 278197004891 EamA-like transporter family; Region: EamA; pfam00892 278197004892 Transcriptional regulators [Transcription]; Region: MarR; COG1846 278197004893 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 278197004894 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 278197004895 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 278197004896 Walker A/P-loop; other site 278197004897 ATP binding site [chemical binding]; other site 278197004898 Q-loop/lid; other site 278197004899 ABC transporter signature motif; other site 278197004900 Walker B; other site 278197004901 D-loop; other site 278197004902 H-loop/switch region; other site 278197004903 ABC transporter; Region: ABC_tran_2; pfam12848 278197004904 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 278197004905 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 278197004906 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 278197004907 Walker A/P-loop; other site 278197004908 ATP binding site [chemical binding]; other site 278197004909 Q-loop/lid; other site 278197004910 ABC transporter signature motif; other site 278197004911 Walker B; other site 278197004912 D-loop; other site 278197004913 H-loop/switch region; other site 278197004914 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 278197004915 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 278197004916 FtsX-like permease family; Region: FtsX; pfam02687 278197004917 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 278197004918 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 278197004919 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 278197004920 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 278197004921 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 278197004922 motif II; other site 278197004923 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 278197004924 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278197004925 dimer interface [polypeptide binding]; other site 278197004926 conserved gate region; other site 278197004927 putative PBP binding loops; other site 278197004928 ABC-ATPase subunit interface; other site 278197004929 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 278197004930 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 278197004931 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 278197004932 dimer interface [polypeptide binding]; other site 278197004933 conserved gate region; other site 278197004934 putative PBP binding loops; other site 278197004935 ABC-ATPase subunit interface; other site 278197004936 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 278197004937 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 278197004938 Walker A/P-loop; other site 278197004939 ATP binding site [chemical binding]; other site 278197004940 Q-loop/lid; other site 278197004941 ABC transporter signature motif; other site 278197004942 Walker B; other site 278197004943 D-loop; other site 278197004944 H-loop/switch region; other site 278197004945 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 278197004946 peptidase T; Region: peptidase-T; TIGR01882 278197004947 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 278197004948 metal binding site [ion binding]; metal-binding site 278197004949 dimer interface [polypeptide binding]; other site 278197004950 putative oxidoreductase; Provisional; Region: PRK10206 278197004951 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 278197004952 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 278197004953 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 278197004954 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 278197004955 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 278197004956 Walker A/P-loop; other site 278197004957 ATP binding site [chemical binding]; other site 278197004958 Q-loop/lid; other site 278197004959 ABC transporter signature motif; other site 278197004960 Walker B; other site 278197004961 D-loop; other site 278197004962 H-loop/switch region; other site 278197004963 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 278197004964 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 278197004965 putative Zn2+ binding site [ion binding]; other site 278197004966 putative DNA binding site [nucleotide binding]; other site 278197004967 phosphotransferase mannnose-specific family component IIA; Provisional; Region: PRK14484 278197004968 dihydroxyacetone kinase, phosphoprotein-dependent, L subunit; Region: dha_L_ycgS; TIGR02365 278197004969 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481 278197004970 Dihydroxyacetone kinase [Carbohydrate transport and metabolism]; Region: DAK1; COG2376 278197004971 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 278197004972 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 278197004973 synthetase active site [active] 278197004974 NTP binding site [chemical binding]; other site 278197004975 metal binding site [ion binding]; metal-binding site 278197004976 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 278197004977 Asp23 family; Region: Asp23; pfam03780 278197004978 Asp23 family; Region: Asp23; pfam03780 278197004979 Predicted membrane protein [Function unknown]; Region: COG2261 278197004980 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 278197004981 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 278197004982 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 278197004983 active site 278197004984 dimer interface [polypeptide binding]; other site 278197004985 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 278197004986 active site 278197004987 catalytic residues [active] 278197004988 metal binding site [ion binding]; metal-binding site 278197004989 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 278197004990 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 278197004991 Coenzyme A binding pocket [chemical binding]; other site 278197004992 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 278197004993 MarR family; Region: MarR; pfam01047 278197004994 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 278197004995 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 278197004996 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 278197004997 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 278197004998 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 278197004999 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 278197005000 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 278197005001 Walker A/P-loop; other site 278197005002 ATP binding site [chemical binding]; other site 278197005003 Q-loop/lid; other site 278197005004 ABC transporter signature motif; other site 278197005005 Walker B; other site 278197005006 D-loop; other site 278197005007 H-loop/switch region; other site 278197005008 Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599 278197005009 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 278197005010 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 278197005011 Transcriptional regulator [Transcription]; Region: LysR; COG0583 278197005012 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 278197005013 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 278197005014 dimerization interface [polypeptide binding]; other site 278197005015 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 278197005016 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 278197005017 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 278197005018 Coenzyme A binding pocket [chemical binding]; other site 278197005019 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 278197005020 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197005021 putative substrate translocation pore; other site 278197005022 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 278197005023 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 278197005024 Ligand Binding Site [chemical binding]; other site 278197005025 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 278197005026 amphipathic channel; other site 278197005027 Asn-Pro-Ala signature motifs; other site 278197005028 Protein of unknown function DUF111; Region: DUF111; pfam01969 278197005029 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 278197005030 AIR carboxylase; Region: AIRC; smart01001 278197005031 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 278197005032 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 278197005033 Cyclic nucleotide-binding domain; Region: cNMP_binding; pfam00027 278197005034 ligand binding site [chemical binding]; other site 278197005035 flexible hinge region; other site 278197005036 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 278197005037 non-specific DNA interactions [nucleotide binding]; other site 278197005038 DNA binding site [nucleotide binding] 278197005039 sequence specific DNA binding site [nucleotide binding]; other site 278197005040 putative cAMP binding site [chemical binding]; other site 278197005041 High-affinity nickel permease [Inorganic ion transport and metabolism]; Region: HoxN; COG3376 278197005042 Sugar transport protein; Region: Sugar_transport; pfam06800 278197005043 D-ribose pyranase; Provisional; Region: PRK11797 278197005044 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 278197005045 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 278197005046 substrate binding site [chemical binding]; other site 278197005047 dimer interface [polypeptide binding]; other site 278197005048 ATP binding site [chemical binding]; other site 278197005049 Transcriptional regulators [Transcription]; Region: PurR; COG1609 278197005050 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 278197005051 DNA binding site [nucleotide binding] 278197005052 domain linker motif; other site 278197005053 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 278197005054 dimerization interface [polypeptide binding]; other site 278197005055 ligand binding site [chemical binding]; other site 278197005056 manganese transport protein MntH; Reviewed; Region: PRK00701 278197005057 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 278197005058 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 278197005059 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 278197005060 DXD motif; other site 278197005061 PilZ domain; Region: PilZ; pfam07238 278197005062 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 278197005063 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 278197005064 Ligand binding site; other site 278197005065 Putative Catalytic site; other site 278197005066 DXD motif; other site 278197005067 Predicted membrane protein [Function unknown]; Region: COG2246 278197005068 GtrA-like protein; Region: GtrA; pfam04138 278197005069 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 278197005070 catalytic core [active] 278197005071 AP2 domain; Region: AP2; pfam00847 278197005072 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 278197005073 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 278197005074 catalytic residues [active] 278197005075 catalytic nucleophile [active] 278197005076 Presynaptic Site I dimer interface [polypeptide binding]; other site 278197005077 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 278197005078 Synaptic Flat tetramer interface [polypeptide binding]; other site 278197005079 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 278197005080 NADH(P)-binding; Region: NAD_binding_10; pfam13460 278197005081 NAD(P) binding site [chemical binding]; other site 278197005082 putative active site [active] 278197005083 Solo B3/4 domain (OB-fold DNA/RNA-binding) of Phe-aaRS-beta [General function prediction only]; Region: COG3382 278197005084 B3/4 domain; Region: B3_4; pfam03483 278197005085 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 278197005086 catalytic core [active] 278197005087 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 278197005088 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 278197005089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278197005090 S-adenosylmethionine binding site [chemical binding]; other site 278197005091 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 278197005092 AzlC protein; Region: AzlC; pfam03591 278197005093 D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686 278197005094 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 278197005095 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 278197005096 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 278197005097 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 278197005098 dimer interface [polypeptide binding]; other site 278197005099 phosphorylation site [posttranslational modification] 278197005100 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278197005101 ATP binding site [chemical binding]; other site 278197005102 Mg2+ binding site [ion binding]; other site 278197005103 G-X-G motif; other site 278197005104 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 278197005105 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278197005106 active site 278197005107 phosphorylation site [posttranslational modification] 278197005108 intermolecular recognition site; other site 278197005109 dimerization interface [polypeptide binding]; other site 278197005110 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 278197005111 DNA binding site [nucleotide binding] 278197005112 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 278197005113 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 278197005114 DNA binding site [nucleotide binding] 278197005115 active site 278197005116 inosine 5-monophosphate dehydrogenase; Validated; Region: PRK06843 278197005117 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 278197005118 active site 278197005119 Protein of unknown function (DUF1129); Region: DUF1129; pfam06570 278197005120 GTP-binding protein YchF; Reviewed; Region: PRK09601 278197005121 YchF GTPase; Region: YchF; cd01900 278197005122 G1 box; other site 278197005123 GTP/Mg2+ binding site [chemical binding]; other site 278197005124 Switch I region; other site 278197005125 G2 box; other site 278197005126 Switch II region; other site 278197005127 G3 box; other site 278197005128 G4 box; other site 278197005129 G5 box; other site 278197005130 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 278197005131 Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107 278197005132 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 278197005133 ParB-like nuclease domain; Region: ParB; smart00470 278197005134 KorB domain; Region: KorB; pfam08535 278197005135 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 278197005136 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 278197005137 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 278197005138 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 278197005139 Coenzyme A binding pocket [chemical binding]; other site 278197005140 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 278197005141 active site 278197005142 tetramer interface [polypeptide binding]; other site 278197005143 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 278197005144 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 278197005145 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 278197005146 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 278197005147 DEAD/DEAH box helicase; Region: DEAD; pfam00270 278197005148 DEAD_2; Region: DEAD_2; pfam06733 278197005149 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 278197005150 NlpC/P60 family; Region: NLPC_P60; pfam00877 278197005151 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 278197005152 Protein of unknown function (DUF972); Region: DUF972; pfam06156 278197005153 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 278197005154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197005155 putative substrate translocation pore; other site 278197005156 TRAM domain; Region: TRAM; pfam01938 278197005157 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 278197005158 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 278197005159 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 278197005160 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278197005161 active site 278197005162 phosphorylation site [posttranslational modification] 278197005163 intermolecular recognition site; other site 278197005164 dimerization interface [polypeptide binding]; other site 278197005165 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 278197005166 DNA binding residues [nucleotide binding] 278197005167 dimerization interface [polypeptide binding]; other site 278197005168 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 278197005169 Histidine kinase; Region: HisKA_3; pfam07730 278197005170 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278197005171 ATP binding site [chemical binding]; other site 278197005172 Mg2+ binding site [ion binding]; other site 278197005173 G-X-G motif; other site 278197005174 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 278197005175 Der1-like family; Region: DER1; cl17806 278197005176 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 278197005177 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 278197005178 Walker A/P-loop; other site 278197005179 ATP binding site [chemical binding]; other site 278197005180 Q-loop/lid; other site 278197005181 ABC transporter signature motif; other site 278197005182 Walker B; other site 278197005183 D-loop; other site 278197005184 H-loop/switch region; other site 278197005185 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 278197005186 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 278197005187 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 278197005188 yrhL-like subfamily of SGNH-hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_yrhL_like; cd01840 278197005189 catalytic triad [active] 278197005190 catalytic triad [active] 278197005191 oxyanion hole [active] 278197005192 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 278197005193 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 278197005194 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 278197005195 Walker A/P-loop; other site 278197005196 ATP binding site [chemical binding]; other site 278197005197 Q-loop/lid; other site 278197005198 ABC transporter signature motif; other site 278197005199 Walker B; other site 278197005200 D-loop; other site 278197005201 H-loop/switch region; other site 278197005202 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 278197005203 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 278197005204 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 278197005205 catalytic residue [active] 278197005206 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 278197005207 endonuclease III; Region: ENDO3c; smart00478 278197005208 minor groove reading motif; other site 278197005209 helix-hairpin-helix signature motif; other site 278197005210 substrate binding pocket [chemical binding]; other site 278197005211 active site 278197005212 Peptidase family C69; Region: Peptidase_C69; pfam03577 278197005213 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 278197005214 Protein of unknown function (DUF2922); Region: DUF2922; pfam11148 278197005215 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 278197005216 MarR family; Region: MarR_2; pfam12802 278197005217 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 278197005218 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 278197005219 active site 278197005220 dimer interface [polypeptide binding]; other site 278197005221 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 278197005222 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 278197005223 dimer interface [polypeptide binding]; other site 278197005224 active site 278197005225 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 278197005226 putative active site [active] 278197005227 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 278197005228 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278197005229 DNA-binding site [nucleotide binding]; DNA binding site 278197005230 UTRA domain; Region: UTRA; pfam07702 278197005231 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 278197005232 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 278197005233 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 278197005234 active site 278197005235 phosphorylation site [posttranslational modification] 278197005236 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 278197005237 active pocket/dimerization site; other site 278197005238 active site 278197005239 phosphorylation site [posttranslational modification] 278197005240 Domain of unknown function (DUF303); Region: DUF303; pfam03629 278197005241 Aldose 1-epimerase, similar to Lactococcus lactis lacX; Region: Aldose_epim_lacX; cd09024 278197005242 active site 278197005243 catalytic residues [active] 278197005244 QueT transporter; Region: QueT; pfam06177 278197005245 Arginate lyase and other MDR family members; Region: AL_MDR; cd08252 278197005246 zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817 278197005247 putative NAD(P) binding site [chemical binding]; other site 278197005248 dimer interface [polypeptide binding]; other site 278197005249 Predicted transcriptional regulator [Transcription]; Region: COG1959 278197005250 Transcriptional regulator; Region: Rrf2; pfam02082 278197005251 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 278197005252 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 278197005253 NADP binding site [chemical binding]; other site 278197005254 Protein of unknown function (DUF3923); Region: DUF3923; pfam13061 278197005255 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 278197005256 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 278197005257 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 278197005258 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 278197005259 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 278197005260 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 278197005261 E3 interaction surface; other site 278197005262 lipoyl attachment site [posttranslational modification]; other site 278197005263 e3 binding domain; Region: E3_binding; pfam02817 278197005264 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 278197005265 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 278197005266 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 278197005267 alpha subunit interface [polypeptide binding]; other site 278197005268 TPP binding site [chemical binding]; other site 278197005269 heterodimer interface [polypeptide binding]; other site 278197005270 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 278197005271 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 278197005272 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 278197005273 TPP-binding site [chemical binding]; other site 278197005274 tetramer interface [polypeptide binding]; other site 278197005275 heterodimer interface [polypeptide binding]; other site 278197005276 phosphorylation loop region [posttranslational modification] 278197005277 lipoyltransferase and lipoate-protein ligase; Region: lipoyltrans; TIGR00545 278197005278 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 278197005279 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 278197005280 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 278197005281 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 278197005282 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 278197005283 beta-galactosidase; Region: BGL; TIGR03356 278197005284 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 278197005285 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278197005286 DNA-binding site [nucleotide binding]; DNA binding site 278197005287 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 278197005288 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 278197005289 putative FMN binding site [chemical binding]; other site 278197005290 Predicted membrane protein [Function unknown]; Region: COG1511 278197005291 YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061 278197005292 X-X-X-Leu-X-X-Gly heptad repeats; Region: xxxLxxG_by_4; TIGR03057 278197005293 Predicted membrane protein [Function unknown]; Region: COG1511 278197005294 YhgE/Pip C-terminal domain; Region: pip_yhgE_Cterm; TIGR03062 278197005295 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 278197005296 dimerization interface [polypeptide binding]; other site 278197005297 putative DNA binding site [nucleotide binding]; other site 278197005298 putative Zn2+ binding site [ion binding]; other site 278197005299 Domain of unknown function (DUF1836); Region: DUF1836; pfam08876 278197005300 EDD domain protein, DegV family; Region: DegV; TIGR00762 278197005301 Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645 278197005302 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 278197005303 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 278197005304 S-adenosylmethionine binding site [chemical binding]; other site 278197005305 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 278197005306 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 278197005307 Bacterial low temperature requirement A protein (LtrA); Region: LtrA; cl01754 278197005308 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 278197005309 dimanganese center [ion binding]; other site 278197005310 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 278197005311 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 278197005312 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 278197005313 metal binding site [ion binding]; metal-binding site 278197005314 active site 278197005315 I-site; other site 278197005316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197005317 Major Facilitator Superfamily; Region: MFS_1; pfam07690 278197005318 putative substrate translocation pore; other site 278197005319 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 278197005320 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 278197005321 protein binding site [polypeptide binding]; other site 278197005322 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 278197005323 YycH protein; Region: YycI; pfam09648 278197005324 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4863 278197005325 YycH protein; Region: YycH; pfam07435 278197005326 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 278197005327 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002 278197005328 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 278197005329 dimerization interface [polypeptide binding]; other site 278197005330 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 278197005331 putative active site [active] 278197005332 heme pocket [chemical binding]; other site 278197005333 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 278197005334 dimer interface [polypeptide binding]; other site 278197005335 phosphorylation site [posttranslational modification] 278197005336 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 278197005337 ATP binding site [chemical binding]; other site 278197005338 Mg2+ binding site [ion binding]; other site 278197005339 G-X-G motif; other site 278197005340 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 278197005341 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 278197005342 active site 278197005343 phosphorylation site [posttranslational modification] 278197005344 intermolecular recognition site; other site 278197005345 dimerization interface [polypeptide binding]; other site 278197005346 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 278197005347 DNA binding site [nucleotide binding] 278197005348 Transcriptional regulator [Transcription]; Region: LysR; COG0583 278197005349 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 278197005350 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 278197005351 dimerization interface [polypeptide binding]; other site 278197005352 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197005353 NADH(P)-binding; Region: NAD_binding_10; pfam13460 278197005354 NAD(P) binding site [chemical binding]; other site 278197005355 active site 278197005356 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 278197005357 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 278197005358 putative substrate translocation pore; other site 278197005359 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 278197005360 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 278197005361 active site 278197005362 motif I; other site 278197005363 motif II; other site 278197005364 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 278197005365 HPr interaction site; other site 278197005366 glycerol kinase (GK) interaction site [polypeptide binding]; other site 278197005367 active site 278197005368 phosphorylation site [posttranslational modification] 278197005369 PTS system, sucrose-specific IIBC component; Region: PTS-II-BC-sucr; TIGR01996 278197005370 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 278197005371 active site turn [active] 278197005372 phosphorylation site [posttranslational modification] 278197005373 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 278197005374 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 278197005375 DNA-binding site [nucleotide binding]; DNA binding site 278197005376 trehalose operon repressor, B. subtilis-type; Region: trehalos_R_Bsub; TIGR02404 278197005377 UTRA domain; Region: UTRA; pfam07702 278197005378 alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403 278197005379 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 278197005380 Ca binding site [ion binding]; other site 278197005381 active site 278197005382 catalytic site [active] 278197005383 C-terminal domain of adaptor protein (AP) complexes medium mu subunits and its homologs (MHD); Region: AP_MHD_Cterm; cl10970 278197005384 Transcriptional regulators [Transcription]; Region: PurR; COG1609 278197005385 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 278197005386 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 278197005387 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 278197005388 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 278197005389 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 278197005390 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 278197005391 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 278197005392 Walker A/P-loop; other site 278197005393 ATP binding site [chemical binding]; other site 278197005394 Q-loop/lid; other site 278197005395 ABC transporter signature motif; other site 278197005396 Walker B; other site 278197005397 D-loop; other site 278197005398 H-loop/switch region; other site 278197005399 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 278197005400 FtsX-like permease family; Region: FtsX; pfam02687 278197005401 Transcriptional regulators [Transcription]; Region: MarR; COG1846 278197005402 MarR family; Region: MarR_2; pfam12802 278197005403 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 278197005404 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 278197005405 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 278197005406 active site turn [active] 278197005407 phosphorylation site [posttranslational modification] 278197005408 Phosphotransferase system IIA components [Carbohydrate transport and metabolism]; Region: NagE; COG2190 278197005409 HPr interaction site; other site 278197005410 glycerol kinase (GK) interaction site [polypeptide binding]; other site 278197005411 active site 278197005412 phosphorylation site [posttranslational modification] 278197005413 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 278197005414 homopentamer interface [polypeptide binding]; other site 278197005415 active site 278197005416 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 278197005417 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 278197005418 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 278197005419 dimerization interface [polypeptide binding]; other site 278197005420 active site 278197005421 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 278197005422 Lumazine binding domain; Region: Lum_binding; pfam00677 278197005423 Lumazine binding domain; Region: Lum_binding; pfam00677 278197005424 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 278197005425 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 278197005426 catalytic motif [active] 278197005427 Zn binding site [ion binding]; other site 278197005428 RibD C-terminal domain; Region: RibD_C; cl17279 278197005429 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 278197005430 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 278197005431 NAD(P) binding site [chemical binding]; other site 278197005432 catalytic residues [active] 278197005433 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 278197005434 propionate/acetate kinase; Provisional; Region: PRK12379 278197005435 Predicted transcriptional regulators [Transcription]; Region: COG1695 278197005436 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 278197005437 Predicted membrane protein [Function unknown]; Region: COG4709 278197005438 Domain of unknown function (DUF4097); Region: DUF4097; pfam13349 278197005439 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 278197005440 Domain of unknown function (DUF4098); Region: DUF4098; pfam13345 278197005441 Microcin C7 self-immunity protein determines resistance to exogenous microcin C7; Region: Peptidase_S66_mccF_like; cd07062 278197005442 putative dimer interface [polypeptide binding]; other site 278197005443 catalytic triad [active] 278197005444 Protein of unknown function (DUF454); Region: DUF454; cl01063 278197005445 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 278197005446 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 278197005447 salt bridge; other site 278197005448 non-specific DNA binding site [nucleotide binding]; other site 278197005449 sequence-specific DNA binding site [nucleotide binding]; other site 278197005450 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 278197005451 helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785 278197005452 Part of AAA domain; Region: AAA_19; pfam13245 278197005453 Family description; Region: UvrD_C_2; pfam13538 278197005454 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 278197005455 helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773 278197005456 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 278197005457 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 278197005458 NAD(P) binding site [chemical binding]; other site 278197005459 active site 278197005460 xanthine permease; Region: pbuX; TIGR03173 278197005461 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 278197005462 Endoglucanase E-like members of the SGNH hydrolase family; Endoglucanase E catalyzes the endohydrolysis of 1,4-beta-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; Region: Endoglucanase_E_like; cd01831 278197005463 active site 278197005464 catalytic triad [active] 278197005465 oxyanion hole [active] 278197005466 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 278197005467 cardiolipin synthase; Region: bac_cardiolipin; TIGR04265 278197005468 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 278197005469 putative active site [active] 278197005470 catalytic site [active] 278197005471 catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112 278197005472 putative active site [active] 278197005473 catalytic site [active] 278197005474 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 278197005475 nucleotide binding site/active site [active] 278197005476 HIT family signature motif; other site 278197005477 catalytic residue [active] 278197005478 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 278197005479 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 278197005480 Catalytic site [active] 278197005481 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 278197005482 hypothetical protein; Validated; Region: PRK02101 278197005483 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 278197005484 tRNA:m(5)U-54 methyltransferase; Region: gid_trmFO; TIGR00137 278197005485 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 278197005486 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 278197005487 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 278197005488 trmE is a tRNA modification GTPase; Region: trmE; cd04164 278197005489 G1 box; other site 278197005490 GTP/Mg2+ binding site [chemical binding]; other site 278197005491 Switch I region; other site 278197005492 G2 box; other site 278197005493 Switch II region; other site 278197005494 G3 box; other site 278197005495 G4 box; other site 278197005496 G5 box; other site 278197005497 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 278197005498 Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706 278197005499 60Kd inner membrane protein; Region: 60KD_IMP; cl00489 278197005500 ribonuclease P; Reviewed; Region: rnpA; PRK00499 278197005501 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399