-- dump date   	20140619_233105
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
324925000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
324925000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
324925000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
324925000004	Walker A motif; other site
324925000005	ATP binding site [chemical binding]; other site
324925000006	Walker B motif; other site
324925000007	arginine finger; other site
324925000008	Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443
324925000009	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
324925000010	DnaA box-binding interface [nucleotide binding]; other site
324925000011	DNA polymerase III subunit beta; Provisional; Region: PRK14941
324925000012	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
324925000013	putative DNA binding surface [nucleotide binding]; other site
324925000014	dimer interface [polypeptide binding]; other site
324925000015	beta-clamp/clamp loader binding surface; other site
324925000016	beta-clamp/translesion DNA polymerase binding surface; other site
324925000017	recombination protein F; Reviewed; Region: recF; PRK00064
324925000018	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
324925000019	Walker A/P-loop; other site
324925000020	ATP binding site [chemical binding]; other site
324925000021	Q-loop/lid; other site
324925000022	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
324925000023	ABC transporter signature motif; other site
324925000024	Walker B; other site
324925000025	D-loop; other site
324925000026	H-loop/switch region; other site
324925000027	Protein of unknown function (DUF721); Region: DUF721; pfam05258
324925000028	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
324925000029	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
324925000030	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
324925000031	DNA polymerase elongation subunit (family B) [DNA replication, recombination, and repair]; Region: PolB; COG0417
324925000032	Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like2_exo; cd05785
324925000033	active site
324925000034	catalytic site [active]
324925000035	substrate binding site [chemical binding]; other site
324925000036	DNA polymerase type-II B subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II_B; cd05538
324925000037	active site
324925000038	metal-binding site
324925000039	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
324925000040	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
324925000041	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
324925000042	Predicted secreted protein [Function unknown]; Region: COG5501
324925000043	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
324925000044	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
324925000045	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
324925000046	Cytochrome c; Region: Cytochrom_C; cl11414
324925000047	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
324925000048	Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242
324925000049	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
324925000050	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
324925000051	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
324925000052	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
324925000053	Protein export membrane protein; Region: SecD_SecF; pfam02355
324925000054	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
324925000055	SurA N-terminal domain; Region: SurA_N; pfam09312
324925000056	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
324925000057	nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933
324925000058	PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616
324925000059	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
324925000060	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
324925000061	ATP binding site [chemical binding]; other site
324925000062	Mg2+ binding site [ion binding]; other site
324925000063	G-X-G motif; other site
324925000064	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
324925000065	anchoring element; other site
324925000066	dimer interface [polypeptide binding]; other site
324925000067	ATP binding site [chemical binding]; other site
324925000068	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
324925000069	active site
324925000070	putative metal-binding site [ion binding]; other site
324925000071	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
324925000072	hypothetical protein; Reviewed; Region: PRK12497
324925000073	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
324925000074	RNA/DNA hybrid binding site [nucleotide binding]; other site
324925000075	active site
324925000076	Conserved hypothetical protein (DUF2461); Region: DUF2461; pfam09365
324925000077	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
324925000078	HicB family; Region: HicB; pfam05534
324925000079	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
324925000080	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
324925000081	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
324925000082	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
324925000083	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
324925000084	trimer interface [polypeptide binding]; other site
324925000085	active site
324925000086	substrate binding site [chemical binding]; other site
324925000087	CoA binding site [chemical binding]; other site
324925000088	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
324925000089	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
324925000090	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
324925000091	protein binding site [polypeptide binding]; other site
324925000092	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
324925000093	Catalytic dyad [active]
324925000094	Protein of unknown function (DUF2499); Region: DUF2499; pfam10693
324925000095	Protein of unknown function (DUF3593); Region: DUF3593; pfam12159
324925000096	geranylgeranyl reductase; Region: BchP-ChlP; TIGR02023
324925000097	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
324925000098	glycyl-tRNA synthetase; Provisional; Region: PRK04173
324925000099	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
324925000100	motif 1; other site
324925000101	Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774
324925000102	active site
324925000103	motif 2; other site
324925000104	motif 3; other site
324925000105	GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858
324925000106	anticodon binding site; other site
324925000107	Predicted peroxiredoxins [General function prediction only]; Region: COG2044
324925000108	Flagellin N-methylase; Region: FliB; pfam03692
324925000109	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
324925000110	CitB domain protein; Region: CitB; TIGR02484
324925000111	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
324925000112	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
324925000113	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
324925000114	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
324925000115	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
324925000116	adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854
324925000117	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
324925000118	adenosine phosphosulphate reductase, beta subunit; Region: aprB; TIGR02060
324925000119	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
324925000120	Adenosine-5'-phosphosulfate reductase beta subunit; Region: APS-reductase_C; pfam12139
324925000121	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
324925000122	ATP-sulfurylase; Region: ATPS; cd00517
324925000123	active site
324925000124	HXXH motif; other site
324925000125	flexible loop; other site
324925000126	Predicted membrane protein [Function unknown]; Region: COG2855
324925000127	ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617
324925000128	LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025
324925000129	dimer interface [polypeptide binding]; other site
324925000130	catalytic triad [active]
324925000131	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
324925000132	gamma subunit interface [polypeptide binding]; other site
324925000133	epsilon subunit interface [polypeptide binding]; other site
324925000134	LBP interface [polypeptide binding]; other site
324925000135	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
324925000136	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
324925000137	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
324925000138	alpha subunit interaction interface [polypeptide binding]; other site
324925000139	Walker A motif; other site
324925000140	ATP binding site [chemical binding]; other site
324925000141	Walker B motif; other site
324925000142	inhibitor binding site; inhibition site
324925000143	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
324925000144	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
324925000145	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
324925000146	catalytic residues [active]
324925000147	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_GTP; cd00819
324925000148	active site
324925000149	substrate-binding site [chemical binding]; other site
324925000150	metal-binding site [ion binding]
324925000151	GTP binding site [chemical binding]; other site
324925000152	Dodecin; Region: Dodecin; pfam07311
324925000153	Uncharacterized conserved protein [Function unknown]; Region: COG4279
324925000154	SWIM zinc finger; Region: SWIM; pfam04434
324925000155	SNF2 Helicase protein; Region: DUF3670; pfam12419
324925000156	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
324925000157	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
324925000158	ATP binding site [chemical binding]; other site
324925000159	putative Mg++ binding site [ion binding]; other site
324925000160	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
324925000161	nucleotide binding region [chemical binding]; other site
324925000162	ATP-binding site [chemical binding]; other site
324925000163	H+ Antiporter protein; Region: 2A0121; TIGR00900
324925000164	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
324925000165	putative substrate translocation pore; other site
324925000166	putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830
324925000167	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
324925000168	non-specific DNA binding site [nucleotide binding]; other site
324925000169	salt bridge; other site
324925000170	sequence-specific DNA binding site [nucleotide binding]; other site
324925000171	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
324925000172	hypothetical protein; Provisional; Region: PRK10396
324925000173	yecA family protein; Region: ygfB_yecA; TIGR02292
324925000174	Putative addiction module component; Region: Unstab_antitox; pfam09720
324925000175	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
324925000176	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
324925000177	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
324925000178	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
324925000179	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
324925000180	putative substrate translocation pore; other site
324925000181	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
324925000182	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
324925000183	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
324925000184	HlyD family secretion protein; Region: HlyD_3; pfam13437
324925000185	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
324925000186	Ligand Binding Site [chemical binding]; other site
324925000187	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
324925000188	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
324925000189	GAF domain; Region: GAF_3; pfam13492
324925000190	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
324925000191	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
324925000192	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
324925000193	Walker A motif; other site
324925000194	ATP binding site [chemical binding]; other site
324925000195	Walker B motif; other site
324925000196	arginine finger; other site
324925000197	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
324925000198	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
324925000199	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
324925000200	pyridoxal 5'-phosphate binding site [chemical binding]; other site
324925000201	homodimer interface [polypeptide binding]; other site
324925000202	catalytic residue [active]
324925000203	ACT domain-containing protein [General function prediction only]; Region: COG4747
324925000204	N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908
324925000205	C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882
324925000206	Astacin (Peptidase family M12A); Region: Astacin; pfam01400
324925000207	Zinc-dependent metalloprotease, astacin_like subfamily or peptidase family M12A, a group of zinc-dependent proteolytic enzymes with a HExxH zinc-binding site/active site. Members of this family may have an amino terminal propeptide, which is cleaved to...; Region: ZnMc_astacin_like; cd04280
324925000208	active site
324925000209	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; cl05126
324925000210	putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055
324925000211	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
324925000212	FeS/SAM binding site; other site
324925000213	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
324925000214	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
324925000215	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
324925000216	acyl-activating enzyme (AAE) consensus motif; other site
324925000217	AMP binding site [chemical binding]; other site
324925000218	active site
324925000219	CoA binding site [chemical binding]; other site
324925000220	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
324925000221	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
324925000222	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
324925000223	dimer interface [polypeptide binding]; other site
324925000224	PYR/PP interface [polypeptide binding]; other site
324925000225	TPP binding site [chemical binding]; other site
324925000226	substrate binding site [chemical binding]; other site
324925000227	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
324925000228	TPP-binding site; other site
324925000229	Response regulator receiver domain; Region: Response_reg; pfam00072
324925000230	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
324925000231	active site
324925000232	phosphorylation site [posttranslational modification]
324925000233	intermolecular recognition site; other site
324925000234	dimerization interface [polypeptide binding]; other site
324925000235	nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938
324925000236	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
324925000237	putative active site [active]
324925000238	heme pocket [chemical binding]; other site
324925000239	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
324925000240	putative active site [active]
324925000241	heme pocket [chemical binding]; other site
324925000242	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
324925000243	dimer interface [polypeptide binding]; other site
324925000244	phosphorylation site [posttranslational modification]
324925000245	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
324925000246	ATP binding site [chemical binding]; other site
324925000247	Mg2+ binding site [ion binding]; other site
324925000248	G-X-G motif; other site
324925000249	peptide chain release factor 1; Validated; Region: prfA; PRK00591
324925000250	PCRF domain; Region: PCRF; pfam03462
324925000251	RF-1 domain; Region: RF-1; pfam00472
324925000252	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
324925000253	RIP metalloprotease RseP; Region: TIGR00054
324925000254	active site
324925000255	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
324925000256	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
324925000257	protein binding site [polypeptide binding]; other site
324925000258	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
324925000259	putative substrate binding region [chemical binding]; other site
324925000260	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
324925000261	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
324925000262	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
324925000263	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
324925000264	FtsH Extracellular; Region: FtsH_ext; pfam06480
324925000265	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
324925000266	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
324925000267	Walker B motif; other site
324925000268	arginine finger; other site
324925000269	Peptidase family M41; Region: Peptidase_M41; pfam01434
324925000270	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
324925000271	active site
324925000272	dimer interface [polypeptide binding]; other site
324925000273	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
324925000274	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
324925000275	glutaminase active site [active]
324925000276	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
324925000277	dimer interface [polypeptide binding]; other site
324925000278	active site
324925000279	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
324925000280	dimer interface [polypeptide binding]; other site
324925000281	active site
324925000282	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
324925000283	TIGR01777 family protein; Region: yfcH
324925000284	putative NAD(P) binding site [chemical binding]; other site
324925000285	putative active site [active]
324925000286	DPS-like protein, ferritin-like diiron-binding domain; Region: DPSL; cd01052
324925000287	Ferritin-like domain; Region: Ferritin; pfam00210
324925000288	diiron binding motif [ion binding]; other site
324925000289	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
324925000290	Nitrogen regulatory protein P-II; Region: P-II; smart00938
324925000291	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
324925000292	TPR repeat; Region: TPR_11; pfam13414
324925000293	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925000294	binding surface
324925000295	TPR motif; other site
324925000296	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925000297	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
324925000298	binding surface
324925000299	TPR motif; other site
324925000300	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
324925000301	Uncharacterized conserved protein [Function unknown]; Region: COG4198
324925000302	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
324925000303	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
324925000304	Glycoprotease family; Region: Peptidase_M22; pfam00814
324925000305	Rifin/stevor family; Region: Rifin_STEVOR; cl14106
324925000306	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
324925000307	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
324925000308	putative active site [active]
324925000309	Oligomerisation domain; Region: Oligomerisation; pfam02410
324925000310	DNA gyrase subunit A; Validated; Region: PRK05560
324925000311	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
324925000312	CAP-like domain; other site
324925000313	active site
324925000314	primary dimer interface [polypeptide binding]; other site
324925000315	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
324925000316	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
324925000317	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
324925000318	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
324925000319	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
324925000320	CTP synthetase; Validated; Region: pyrG; PRK05380
324925000321	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
324925000322	Catalytic site [active]
324925000323	active site
324925000324	UTP binding site [chemical binding]; other site
324925000325	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
324925000326	active site
324925000327	putative oxyanion hole; other site
324925000328	catalytic triad [active]
324925000329	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
324925000330	PHP domain; Region: PHP; pfam02811
324925000331	active site
324925000332	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
324925000333	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
324925000334	dimer interface [polypeptide binding]; other site
324925000335	active site
324925000336	heme binding site [chemical binding]; other site
324925000337	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
324925000338	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
324925000339	metal binding site 2 [ion binding]; metal-binding site
324925000340	putative DNA binding helix; other site
324925000341	metal binding site 1 [ion binding]; metal-binding site
324925000342	dimer interface [polypeptide binding]; other site
324925000343	structural Zn2+ binding site [ion binding]; other site
324925000344	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
324925000345	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
324925000346	aromatic arch; other site
324925000347	DCoH dimer interaction site [polypeptide binding]; other site
324925000348	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
324925000349	DCoH tetramer interaction site [polypeptide binding]; other site
324925000350	substrate binding site [chemical binding]; other site
324925000351	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
324925000352	active site
324925000353	Domain of Unknown Function (DUF3856); Region: DUF3856; pfam12968
324925000354	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925000355	binding surface
324925000356	TPR motif; other site
324925000357	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
324925000358	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
324925000359	putative active site [active]
324925000360	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
324925000361	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
324925000362	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
324925000363	dimer interface [polypeptide binding]; other site
324925000364	ssDNA binding site [nucleotide binding]; other site
324925000365	tetramer (dimer of dimers) interface [polypeptide binding]; other site
324925000366	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
324925000367	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
324925000368	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
324925000369	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
324925000370	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
324925000371	active site residue [active]
324925000372	yecA family protein; Region: ygfB_yecA; TIGR02292
324925000373	Uncharacterized conserved protein [Function unknown]; Region: COG0432
324925000374	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
324925000375	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
324925000376	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
324925000377	transmembrane helices; other site
324925000378	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
324925000379	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
324925000380	Protein export membrane protein; Region: SecD_SecF; cl14618
324925000381	periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578
324925000382	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
324925000383	HlyD family secretion protein; Region: HlyD_3; pfam13437
324925000384	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
324925000385	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
324925000386	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
324925000387	AAA domain; Region: AAA_14; pfam13173
324925000388	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
324925000389	HTH-like domain; Region: HTH_21; pfam13276
324925000390	insertion element IS2 transposase InsD; Provisional; Region: PRK14702
324925000391	Integrase core domain; Region: rve; pfam00665
324925000392	Integrase core domain; Region: rve_3; pfam13683
324925000393	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
324925000394	Transposase; Region: HTH_Tnp_1; cl17663
324925000395	Domain of unknown function (DUF1719); Region: DUF1719; pfam08224
324925000396	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
324925000397	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
324925000398	Walker A motif; other site
324925000399	ATP binding site [chemical binding]; other site
324925000400	Walker B motif; other site
324925000401	arginine finger; other site
324925000402	Protein of unknown function (DUF3018); Region: DUF3018; pfam11455
324925000403	AAA domain; Region: AAA_14; pfam13173
324925000404	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
324925000405	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
324925000406	Predicted transcriptional regulator [Transcription]; Region: COG3905
324925000407	Rrf2 family protein; Region: rrf2_super; TIGR00738
324925000408	Transcriptional regulator; Region: Rrf2; pfam02082
324925000409	4Fe-4S binding domain; Region: Fer4_6; pfam12837
324925000410	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
324925000411	TPR repeat; Region: TPR_11; pfam13414
324925000412	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925000413	binding surface
324925000414	TPR motif; other site
324925000415	hybrid cluster protein; Provisional; Region: PRK05290
324925000416	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
324925000417	ACS interaction site; other site
324925000418	CODH interaction site; other site
324925000419	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
324925000420	hybrid metal cluster; other site
324925000421	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
324925000422	oligomeric interface; other site
324925000423	putative active site [active]
324925000424	homodimer interface [polypeptide binding]; other site
324925000425	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
324925000426	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
324925000427	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
324925000428	active site
324925000429	NTP binding site [chemical binding]; other site
324925000430	metal binding triad [ion binding]; metal-binding site
324925000431	antibiotic binding site [chemical binding]; other site
324925000432	Putative addiction module component; Region: Unstab_antitox; pfam09720
324925000433	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
324925000434	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
324925000435	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
324925000436	Predicted transcriptional regulator [Transcription]; Region: COG2944
324925000437	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
324925000438	non-specific DNA binding site [nucleotide binding]; other site
324925000439	salt bridge; other site
324925000440	sequence-specific DNA binding site [nucleotide binding]; other site
324925000441	Protein of unknown function (DUF1044); Region: DUF1044; pfam06296
324925000442	Domain of unknown function DUF1828; Region: DUF1828; pfam08861
324925000443	Domain of unknown function DUF1829; Region: DUF1829; pfam08862
324925000444	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
324925000445	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
324925000446	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
324925000447	dimer interface [polypeptide binding]; other site
324925000448	motif 1; other site
324925000449	active site
324925000450	motif 2; other site
324925000451	motif 3; other site
324925000452	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
324925000453	23S rRNA binding site [nucleotide binding]; other site
324925000454	L21 binding site [polypeptide binding]; other site
324925000455	L13 binding site [polypeptide binding]; other site
324925000456	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
324925000457	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
324925000458	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
324925000459	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
324925000460	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
324925000461	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
324925000462	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
324925000463	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
324925000464	active site
324925000465	dimer interface [polypeptide binding]; other site
324925000466	motif 1; other site
324925000467	motif 2; other site
324925000468	motif 3; other site
324925000469	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
324925000470	anticodon binding site; other site
324925000471	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
324925000472	chlorophyllide reductase subunit Z; Region: BchZ; TIGR02014
324925000473	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
324925000474	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
324925000475	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
324925000476	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
324925000477	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
324925000478	tetramer interface [polypeptide binding]; other site
324925000479	pyridoxal 5'-phosphate binding site [chemical binding]; other site
324925000480	catalytic residue [active]
324925000481	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
324925000482	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
324925000483	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
324925000484	putative active site [active]
324925000485	Abi-like protein; Region: Abi_2; pfam07751
324925000486	HTH-like domain; Region: HTH_21; pfam13276
324925000487	insertion element IS2 transposase InsD; Provisional; Region: PRK14702
324925000488	Integrase core domain; Region: rve; pfam00665
324925000489	Integrase core domain; Region: rve_3; pfam13683
324925000490	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
324925000491	Transposase; Region: HTH_Tnp_1; cl17663
324925000492	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
324925000493	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
324925000494	oligomeric interface; other site
324925000495	putative active site [active]
324925000496	homodimer interface [polypeptide binding]; other site
324925000497	ATP-dependent DNA helicase, RecQ family; Region: recQ_fam; TIGR00614
324925000498	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
324925000499	ATP binding site [chemical binding]; other site
324925000500	putative Mg++ binding site [ion binding]; other site
324925000501	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
324925000502	nucleotide binding region [chemical binding]; other site
324925000503	ATP-binding site [chemical binding]; other site
324925000504	P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923
324925000505	AAA ATPase domain; Region: AAA_16; pfam13191
324925000506	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
324925000507	Sel1 repeat; Region: Sel1; pfam08238
324925000508	Sel1-like repeats; Region: SEL1; smart00671
324925000509	tellurite resistance protein terB; Region: terB; cd07176
324925000510	putative metal binding site [ion binding]; other site
324925000511	Domain of unknown function (DUF4016); Region: DUF4016; pfam13208
324925000512	tellurite resistance protein terB; Region: terB; cd07176
324925000513	putative metal binding site [ion binding]; other site
324925000514	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
324925000515	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
324925000516	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
324925000517	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
324925000518	dimerization interface [polypeptide binding]; other site
324925000519	active site
324925000520	metal binding site [ion binding]; metal-binding site
324925000521	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
324925000522	dsRNA binding site [nucleotide binding]; other site
324925000523	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
324925000524	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
324925000525	dimer interface [polypeptide binding]; other site
324925000526	active site
324925000527	acyl carrier protein; Provisional; Region: acpP; PRK00982
324925000528	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
324925000529	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
324925000530	NAD(P) binding site [chemical binding]; other site
324925000531	homotetramer interface [polypeptide binding]; other site
324925000532	homodimer interface [polypeptide binding]; other site
324925000533	active site
324925000534	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
324925000535	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
324925000536	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
324925000537	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
324925000538	dimer interface [polypeptide binding]; other site
324925000539	active site
324925000540	CoA binding pocket [chemical binding]; other site
324925000541	putative phosphate acyltransferase; Provisional; Region: PRK05331
324925000542	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
324925000543	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
324925000544	2-isopropylmalate synthase; Validated; Region: PRK03739
324925000545	Mycobacterium tuberculosis LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA; cd07942
324925000546	active site
324925000547	catalytic residues [active]
324925000548	metal binding site [ion binding]; metal-binding site
324925000549	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
324925000550	Metal binding protein ZntC.  These proteins are predicted to function as initial receptors in ABC transport of metal ions.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: ZntC; cd01018
324925000551	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
324925000552	putative metal binding residues [ion binding]; other site
324925000553	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
324925000554	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
324925000555	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
324925000556	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
324925000557	dimer interface [polypeptide binding]; other site
324925000558	putative PBP binding regions; other site
324925000559	ABC-ATPase subunit  interface; other site
324925000560	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
324925000561	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
324925000562	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
324925000563	active site
324925000564	catalytic site [active]
324925000565	Oxygen tolerance; Region: BatD; pfam13584
324925000566	pyrroline-5-carboxylate reductase; Region: PLN02688
324925000567	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
324925000568	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
324925000569	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
324925000570	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
324925000571	B12 binding site [chemical binding]; other site
324925000572	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
324925000573	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
324925000574	FeS/SAM binding site; other site
324925000575	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
324925000576	homodimer interface [polypeptide binding]; other site
324925000577	pyridoxal 5'-phosphate binding site [chemical binding]; other site
324925000578	catalytic residue [active]
324925000579	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
324925000580	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
324925000581	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
324925000582	catalytic site [active]
324925000583	subunit interface [polypeptide binding]; other site
324925000584	Preprotein translocase subunit; Region: YajC; pfam02699
324925000585	UGMP family protein; Validated; Region: PRK09604
324925000586	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
324925000587	MoxR-like ATPases [General function prediction only]; Region: COG0714
324925000588	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
324925000589	Walker A motif; other site
324925000590	ATP binding site [chemical binding]; other site
324925000591	Walker B motif; other site
324925000592	arginine finger; other site
324925000593	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
324925000594	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
324925000595	metal ion-dependent adhesion site (MIDAS); other site
324925000596	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
324925000597	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
324925000598	ligand binding site [chemical binding]; other site
324925000599	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
324925000600	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
324925000601	ATP binding site [chemical binding]; other site
324925000602	G-X-G motif; other site
324925000603	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
324925000604	CheB methylesterase; Region: CheB_methylest; pfam01339
324925000605	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
324925000606	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
324925000607	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
324925000608	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
324925000609	Leucine-rich repeats of kinetochore protein Cenp-F/LEK1; Region: Cenp-F_leu_zip; pfam10473
324925000610	PAS domain; Region: PAS_10; pfam13596
324925000611	PAS fold; Region: PAS_4; pfam08448
324925000612	PAS fold; Region: PAS_4; pfam08448
324925000613	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
324925000614	putative active site [active]
324925000615	heme pocket [chemical binding]; other site
324925000616	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
324925000617	PAS domain; Region: PAS_9; pfam13426
324925000618	putative active site [active]
324925000619	heme pocket [chemical binding]; other site
324925000620	Winged helix DNA-binding domain; Region: HTH_34; pfam13601
324925000621	YXWGXW repeat (2 copies); Region: YXWGXW; pfam12779
324925000622	RNA polymerase sigma factor; Provisional; Region: PRK11924
324925000623	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
324925000624	This family is most closely related to the GT1 family of glycosyltransferases. aviGT4 in Streptomyces viridochromogenes has been shown to be involved in biosynthesis of oligosaccharide antibiotic avilamycin A. Inactivation of aviGT4 resulted in a mutant...; Region: GT1_AviGT4_like; cd03802
324925000625	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
324925000626	putative ADP-binding pocket [chemical binding]; other site
324925000627	Domain of unknown function (DUF4405); Region: DUF4405; pfam14358
324925000628	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925000629	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925000630	binding surface
324925000631	TPR motif; other site
324925000632	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925000633	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925000634	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925000635	binding surface
324925000636	TPR motif; other site
324925000637	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925000638	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925000639	binding surface
324925000640	TPR motif; other site
324925000641	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925000642	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925000643	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925000644	binding surface
324925000645	TPR motif; other site
324925000646	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925000647	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925000648	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925000649	binding surface
324925000650	TPR motif; other site
324925000651	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925000652	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925000653	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925000654	binding surface
324925000655	TPR motif; other site
324925000656	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925000657	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925000658	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925000659	binding surface
324925000660	TPR motif; other site
324925000661	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925000662	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
324925000663	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
324925000664	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
324925000665	substrate binding pocket [chemical binding]; other site
324925000666	membrane-bound complex binding site; other site
324925000667	hinge residues; other site
324925000668	VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467
324925000669	metal ion-dependent adhesion site (MIDAS); other site
324925000670	von Willebrand factor type A domain; Region: VWA_2; pfam13519
324925000671	metal ion-dependent adhesion site (MIDAS); other site
324925000672	Clp amino terminal domain; Region: Clp_N; pfam02861
324925000673	Clp amino terminal domain; Region: Clp_N; pfam02861
324925000674	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
324925000675	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
324925000676	Walker A motif; other site
324925000677	ATP binding site [chemical binding]; other site
324925000678	Walker B motif; other site
324925000679	arginine finger; other site
324925000680	Surface antigen; Region: Bac_surface_Ag; pfam01103
324925000681	enoyl-CoA hydratase; Provisional; Region: PRK06495
324925000682	AAA ATPase domain; Region: AAA_16; pfam13191
324925000683	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
324925000684	Walker A motif; other site
324925000685	ATP binding site [chemical binding]; other site
324925000686	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
324925000687	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925000688	binding surface
324925000689	TPR motif; other site
324925000690	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
324925000691	TPR motif; other site
324925000692	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925000693	binding surface
324925000694	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925000695	binding surface
324925000696	TPR repeat; Region: TPR_11; pfam13414
324925000697	TPR motif; other site
324925000698	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
324925000699	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
324925000700	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
324925000701	GatB domain; Region: GatB_Yqey; smart00845
324925000702	Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609
324925000703	GTPase CgtA; Reviewed; Region: obgE; PRK12299
324925000704	GTP1/OBG; Region: GTP1_OBG; pfam01018
324925000705	Obg GTPase; Region: Obg; cd01898
324925000706	G1 box; other site
324925000707	GTP/Mg2+ binding site [chemical binding]; other site
324925000708	Switch I region; other site
324925000709	G2 box; other site
324925000710	G3 box; other site
324925000711	Switch II region; other site
324925000712	G4 box; other site
324925000713	G5 box; other site
324925000714	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
324925000715	Coenzyme A binding pocket [chemical binding]; other site
324925000716	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
324925000717	dimerization domain swap beta strand [polypeptide binding]; other site
324925000718	regulatory protein interface [polypeptide binding]; other site
324925000719	active site
324925000720	regulatory phosphorylation site [posttranslational modification]; other site
324925000721	This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822
324925000722	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
324925000723	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
324925000724	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
324925000725	Probable Catalytic site; other site
324925000726	metal-binding site
324925000727	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
324925000728	Methyltransferase domain; Region: Methyltransf_23; pfam13489
324925000729	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
324925000730	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
324925000731	putative homodimer interface [polypeptide binding]; other site
324925000732	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
324925000733	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
324925000734	Bacterial membrane protein YfhO; Region: YfhO; pfam09586
324925000735	HipA-like C-terminal domain; Region: HipA_C; pfam07804
324925000736	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
324925000737	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
324925000738	Walker A motif; other site
324925000739	ATP binding site [chemical binding]; other site
324925000740	Walker B motif; other site
324925000741	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
324925000742	Growth regulator [Signal transduction mechanisms]; Region: MazE; COG2336
324925000743	PemK-like protein; Region: PemK; cl00995
324925000744	HipA N-terminal domain; Region: Couple_hipA; cl11853
324925000745	HipA-like N-terminal domain; Region: HipA_N; pfam07805
324925000746	HipA-like C-terminal domain; Region: HipA_C; pfam07804
324925000747	TIR domain; Region: TIR_2; pfam13676
324925000748	B12 binding domain; Region: B12-binding; pfam02310
324925000749	B12 binding site [chemical binding]; other site
324925000750	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
324925000751	Radical SAM superfamily; Region: Radical_SAM; pfam04055
324925000752	FeS/SAM binding site; other site
324925000753	HAD superfamily (subfamily IA) hydrolase, TIGR02253; Region: CTE7
324925000754	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
324925000755	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
324925000756	dimer interface [polypeptide binding]; other site
324925000757	ADP-ribose binding site [chemical binding]; other site
324925000758	active site
324925000759	nudix motif; other site
324925000760	metal binding site [ion binding]; metal-binding site
324925000761	TIR domain; Region: TIR_2; pfam13676
324925000762	TIR domain; Region: TIR_2; pfam13676
324925000763	Protein of unknown function (DUF499); Region: DUF499; pfam04465
324925000764	Fn3 associated; Region: Fn3_assoc; pfam13287
324925000765	Protein of unknown function (DUF3780); Region: DUF3780; pfam12635
324925000766	Transposase [DNA replication, recombination, and repair]; Region: COG5421
324925000767	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_a; cd09179
324925000768	PLD-like domain; Region: PLDc_2; pfam13091
324925000769	putative active site [active]
324925000770	catalytic site [active]
324925000771	DEAD-like helicases superfamily; Region: DEXDc; smart00487
324925000772	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
324925000773	ATP binding site [chemical binding]; other site
324925000774	putative Mg++ binding site [ion binding]; other site
324925000775	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
324925000776	nucleotide binding region [chemical binding]; other site
324925000777	ATP-binding site [chemical binding]; other site
324925000778	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
324925000779	Putative addiction module component; Region: Unstab_antitox; pfam09720
324925000780	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: HicB; COG4226
324925000781	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
324925000782	S17 interaction site [polypeptide binding]; other site
324925000783	S8 interaction site; other site
324925000784	16S rRNA interaction site [nucleotide binding]; other site
324925000785	streptomycin interaction site [chemical binding]; other site
324925000786	23S rRNA interaction site [nucleotide binding]; other site
324925000787	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
324925000788	30S ribosomal protein S7; Validated; Region: PRK05302
324925000789	elongation factor G; Reviewed; Region: PRK00007
324925000790	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
324925000791	G1 box; other site
324925000792	putative GEF interaction site [polypeptide binding]; other site
324925000793	GTP/Mg2+ binding site [chemical binding]; other site
324925000794	Switch I region; other site
324925000795	G2 box; other site
324925000796	G3 box; other site
324925000797	Switch II region; other site
324925000798	G4 box; other site
324925000799	G5 box; other site
324925000800	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
324925000801	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
324925000802	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
324925000803	elongation factor Tu; Reviewed; Region: PRK00049
324925000804	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
324925000805	G1 box; other site
324925000806	GEF interaction site [polypeptide binding]; other site
324925000807	GTP/Mg2+ binding site [chemical binding]; other site
324925000808	Switch I region; other site
324925000809	G2 box; other site
324925000810	G3 box; other site
324925000811	Switch II region; other site
324925000812	G4 box; other site
324925000813	G5 box; other site
324925000814	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
324925000815	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
324925000816	Antibiotic Binding Site [chemical binding]; other site
324925000817	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
324925000818	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
324925000819	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
324925000820	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
324925000821	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
324925000822	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
324925000823	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
324925000824	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
324925000825	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
324925000826	putative translocon binding site; other site
324925000827	protein-rRNA interface [nucleotide binding]; other site
324925000828	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
324925000829	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
324925000830	G-X-X-G motif; other site
324925000831	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
324925000832	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
324925000833	23S rRNA interface [nucleotide binding]; other site
324925000834	5S rRNA interface [nucleotide binding]; other site
324925000835	putative antibiotic binding site [chemical binding]; other site
324925000836	L25 interface [polypeptide binding]; other site
324925000837	L27 interface [polypeptide binding]; other site
324925000838	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
324925000839	putative translocon interaction site; other site
324925000840	23S rRNA interface [nucleotide binding]; other site
324925000841	signal recognition particle (SRP54) interaction site; other site
324925000842	L23 interface [polypeptide binding]; other site
324925000843	trigger factor interaction site; other site
324925000844	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
324925000845	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
324925000846	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
324925000847	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
324925000848	RNA binding site [nucleotide binding]; other site
324925000849	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
324925000850	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
324925000851	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
324925000852	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
324925000853	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
324925000854	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
324925000855	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
324925000856	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
324925000857	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
324925000858	5S rRNA interface [nucleotide binding]; other site
324925000859	23S rRNA interface [nucleotide binding]; other site
324925000860	L5 interface [polypeptide binding]; other site
324925000861	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
324925000862	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
324925000863	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
324925000864	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
324925000865	23S rRNA binding site [nucleotide binding]; other site
324925000866	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
324925000867	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
324925000868	SecY translocase; Region: SecY; pfam00344
324925000869	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
324925000870	active site
324925000871	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
324925000872	rRNA binding site [nucleotide binding]; other site
324925000873	predicted 30S ribosome binding site; other site
324925000874	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
324925000875	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
324925000876	30S ribosomal protein S13; Region: bact_S13; TIGR03631
324925000877	30S ribosomal protein S11; Validated; Region: PRK05309
324925000878	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
324925000879	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
324925000880	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
324925000881	RNA binding surface [nucleotide binding]; other site
324925000882	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
324925000883	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
324925000884	alphaNTD homodimer interface [polypeptide binding]; other site
324925000885	alphaNTD - beta interaction site [polypeptide binding]; other site
324925000886	alphaNTD - beta' interaction site [polypeptide binding]; other site
324925000887	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
324925000888	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
324925000889	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
324925000890	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
324925000891	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
324925000892	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
324925000893	Substrate binding site; other site
324925000894	Cupin domain; Region: Cupin_2; cl17218
324925000895	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
324925000896	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
324925000897	active site
324925000898	HIGH motif; other site
324925000899	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
324925000900	KMSKS motif; other site
324925000901	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
324925000902	tRNA binding surface [nucleotide binding]; other site
324925000903	anticodon binding site; other site
324925000904	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
324925000905	G1 box; other site
324925000906	GTP/Mg2+ binding site [chemical binding]; other site
324925000907	Switch I region; other site
324925000908	G2 box; other site
324925000909	G3 box; other site
324925000910	Switch II region; other site
324925000911	G4 box; other site
324925000912	G5 box; other site
324925000913	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
324925000914	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
324925000915	GDP-binding site [chemical binding]; other site
324925000916	ACT binding site; other site
324925000917	IMP binding site; other site
324925000918	Domain of unknown function DUF77; Region: DUF77; pfam01910
324925000919	light-independent protochlorophyllide reductase subunit N; Provisional; Region: PRK02842
324925000920	light-independent protochlorophyllide reductase, N subunit; Region: DPOR_bchN; TIGR01279
324925000921	light-independent protochlorophyllide reductase subunit B; Provisional; Region: PRK02910
324925000922	Pchlide_reductase_B: B protein of the NB protein complex of Protochlorophyllide (Pchlide)_reductase. Pchlide reductase catalyzes the reductive formation of chlorophyllide (chlide) from protochlorophyllide (pchlide) during biosynthesis of chlorophylls and...; Region: Pchlide_reductase_B; cd01981
324925000923	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
324925000924	protochlorophyllide reductase iron-sulfur ATP-binding protein; Provisional; Region: chlL; PRK13185
324925000925	This family of proteins contains bchL and chlL. Protochlorophyllide reductase catalyzes the reductive formation of chlorophyllide from protochlorophyllide during biosynthesis of chlorophylls and bacteriochlorophylls. Three genes, bchL, bchN and bchB, are...; Region: Bchl_like; cd02032
324925000926	P-loop; other site
324925000927	four helix bundle suffix domain; Region: 4helix_suffix; TIGR04258
324925000928	V4R domain; Region: V4R; cl15268
324925000929	Bacterial Ig-like domain; Region: Big_5; pfam13205
324925000930	Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316
324925000931	glycogen synthase; Provisional; Region: PRK14098
324925000932	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
324925000933	ADP-binding pocket [chemical binding]; other site
324925000934	homodimer interface [polypeptide binding]; other site
324925000935	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
324925000936	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
324925000937	active site
324925000938	motif I; other site
324925000939	motif II; other site
324925000940	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
324925000941	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
324925000942	FeS/SAM binding site; other site
324925000943	HemN C-terminal domain; Region: HemN_C; pfam06969
324925000944	Protein of unknown function (DUF2723); Region: DUF2723; pfam11028
324925000945	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
324925000946	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
324925000947	active site
324925000948	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
324925000949	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
324925000950	nucleotide binding site [chemical binding]; other site
324925000951	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
324925000952	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
324925000953	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
324925000954	RNA methyltransferase, RsmE family; Region: TIGR00046
324925000955	Domain of unknown function DUF20; Region: UPF0118; pfam01594
324925000956	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
324925000957	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
324925000958	active site
324925000959	multimer interface [polypeptide binding]; other site
324925000960	Transposase domain (DUF772); Region: DUF772; pfam05598
324925000961	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
324925000962	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
324925000963	AIPR protein; Region: AIPR; pfam10592
324925000964	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
324925000965	DNA methylase; Region: N6_N4_Mtase; pfam01555
324925000966	DNA methylase; Region: N6_N4_Mtase; pfam01555
324925000967	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
324925000968	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
324925000969	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
324925000970	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
324925000971	putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574
324925000972	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
324925000973	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
324925000974	FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385
324925000975	Domain of unknown function (DUF4263); Region: DUF4263; pfam14082
324925000976	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
324925000977	active site
324925000978	PspC domain; Region: PspC; pfam04024
324925000979	PAS fold; Region: PAS_4; pfam08448
324925000980	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
324925000981	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
324925000982	putative active site [active]
324925000983	heme pocket [chemical binding]; other site
324925000984	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
324925000985	putative active site [active]
324925000986	heme pocket [chemical binding]; other site
324925000987	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
324925000988	dimer interface [polypeptide binding]; other site
324925000989	[2Fe-2S] cluster binding site [ion binding]; other site
324925000990	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
324925000991	homodimer interaction site [polypeptide binding]; other site
324925000992	cofactor binding site; other site
324925000993	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
324925000994	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
324925000995	catalytic triad [active]
324925000996	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
324925000997	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
324925000998	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
324925000999	catalytic residue [active]
324925001000	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
324925001001	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
324925001002	trimerization site [polypeptide binding]; other site
324925001003	active site
324925001004	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
324925001005	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14340
324925001006	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
324925001007	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
324925001008	FeS/SAM binding site; other site
324925001009	TRAM domain; Region: TRAM; pfam01938
324925001010	bacteriochlorophyll c synthase; Provisional; Region: PRK12392
324925001011	UbiA prenyltransferase family; Region: UbiA; pfam01040
324925001012	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
324925001013	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
324925001014	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
324925001015	putative active site [active]
324925001016	putative metal binding site [ion binding]; other site
324925001017	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
324925001018	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
324925001019	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
324925001020	hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469
324925001021	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
324925001022	DXD motif; other site
324925001023	FOG: WD40 repeat [General function prediction only]; Region: COG2319
324925001024	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
324925001025	structural tetrad; other site
324925001026	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
324925001027	DNA-binding site [nucleotide binding]; DNA binding site
324925001028	RNA-binding motif; other site
324925001029	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
324925001030	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
324925001031	Walker A/P-loop; other site
324925001032	ATP binding site [chemical binding]; other site
324925001033	Q-loop/lid; other site
324925001034	ABC transporter signature motif; other site
324925001035	Walker B; other site
324925001036	D-loop; other site
324925001037	H-loop/switch region; other site
324925001038	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
324925001039	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
324925001040	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
324925001041	Walker A/P-loop; other site
324925001042	ATP binding site [chemical binding]; other site
324925001043	Q-loop/lid; other site
324925001044	ABC transporter signature motif; other site
324925001045	Walker B; other site
324925001046	D-loop; other site
324925001047	H-loop/switch region; other site
324925001048	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
324925001049	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
324925001050	HlyD family secretion protein; Region: HlyD_3; pfam13437
324925001051	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
324925001052	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
324925001053	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
324925001054	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
324925001055	Walker A/P-loop; other site
324925001056	ATP binding site [chemical binding]; other site
324925001057	Q-loop/lid; other site
324925001058	ABC transporter signature motif; other site
324925001059	Walker B; other site
324925001060	D-loop; other site
324925001061	H-loop/switch region; other site
324925001062	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
324925001063	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
324925001064	active site
324925001065	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
324925001066	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
324925001067	Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647
324925001068	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
324925001069	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
324925001070	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
324925001071	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
324925001072	putative ADP-binding pocket [chemical binding]; other site
324925001073	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
324925001074	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
324925001075	putative ADP-binding pocket [chemical binding]; other site
324925001076	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
324925001077	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
324925001078	putative ADP-binding pocket [chemical binding]; other site
324925001079	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
324925001080	CAAX protease self-immunity; Region: Abi; pfam02517
324925001081	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
324925001082	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
324925001083	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
324925001084	active site
324925001085	phosphorylation site [posttranslational modification]
324925001086	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
324925001087	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
324925001088	dimer interface [polypeptide binding]; other site
324925001089	motif 1; other site
324925001090	active site
324925001091	motif 2; other site
324925001092	motif 3; other site
324925001093	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
324925001094	anticodon binding site; other site
324925001095	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
324925001096	hypothetical protein; Provisional; Region: PRK14641
324925001097	NusA N-terminal domain; Region: NusA_N; pfam08529
324925001098	transcription termination factor NusA; Region: NusA; TIGR01953
324925001099	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
324925001100	RNA binding site [nucleotide binding]; other site
324925001101	homodimer interface [polypeptide binding]; other site
324925001102	NusA-like KH domain; Region: KH_5; pfam13184
324925001103	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
324925001104	G-X-X-G motif; other site
324925001105	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
324925001106	translation initiation factor IF-2; Region: IF-2; TIGR00487
324925001107	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
324925001108	G1 box; other site
324925001109	putative GEF interaction site [polypeptide binding]; other site
324925001110	GTP/Mg2+ binding site [chemical binding]; other site
324925001111	Switch I region; other site
324925001112	G2 box; other site
324925001113	G3 box; other site
324925001114	Switch II region; other site
324925001115	G4 box; other site
324925001116	G5 box; other site
324925001117	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
324925001118	Translation-initiation factor 2; Region: IF-2; pfam11987
324925001119	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
324925001120	Ribosome-binding factor A; Region: RBFA; pfam02033
324925001121	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
324925001122	tRNA pseudouridine(55) synthase; Region: TruB; TIGR00431
324925001123	RNA binding site [nucleotide binding]; other site
324925001124	active site
324925001125	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
324925001126	16S/18S rRNA binding site [nucleotide binding]; other site
324925001127	S13e-L30e interaction site [polypeptide binding]; other site
324925001128	25S rRNA binding site [nucleotide binding]; other site
324925001129	hypothetical protein; Provisional; Region: PRK11820
324925001130	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
324925001131	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
324925001132	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
324925001133	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
324925001134	catalytic site [active]
324925001135	G-X2-G-X-G-K; other site
324925001136	PAZ domain, named PAZ after the proteins Piwi Argonaut and Zwille. PAZ is found in two families of proteins that are essential components of RNA-mediated gene-silencing pathways, including RNA interference, the piwi and Dicer families. PAZ functions as a...; Region: PAZ; cl00301
324925001137	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
324925001138	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
324925001139	active site
324925001140	metal binding site [ion binding]; metal-binding site
324925001141	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
324925001142	Substrate binding site; other site
324925001143	Mg++ binding site; other site
324925001144	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
324925001145	tetramerization interface [polypeptide binding]; other site
324925001146	active site
324925001147	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
324925001148	periplasmic chaperone; Provisional; Region: PRK10780
324925001149	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
324925001150	methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444
324925001151	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
324925001152	DNA protecting protein DprA; Region: dprA; TIGR00732
324925001153	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
324925001154	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
324925001155	substrate binding pocket [chemical binding]; other site
324925001156	chain length determination region; other site
324925001157	substrate-Mg2+ binding site; other site
324925001158	catalytic residues [active]
324925001159	aspartate-rich region 1; other site
324925001160	active site lid residues [active]
324925001161	aspartate-rich region 2; other site
324925001162	isopentenyl pyrophosphate isomerase; Provisional; Region: PRK05437
324925001163	Isopentenyl-diphosphate:dimethylallyl diphosphate isomerase type 2 (IDI-2) FMN-binding domain. Two types of IDIs have been characterized at present. The long known IDI-1 is only dependent on divalent metals for activity, whereas IDI-2 requires a metal; Region: IDI-2_FMN; cd02811
324925001164	homotetramer interface [polypeptide binding]; other site
324925001165	FMN binding site [chemical binding]; other site
324925001166	homodimer contacts [polypeptide binding]; other site
324925001167	putative active site [active]
324925001168	putative substrate binding site [chemical binding]; other site
324925001169	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
324925001170	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
324925001171	putative active site [active]
324925001172	putative NTP binding site [chemical binding]; other site
324925001173	putative nucleic acid binding site [nucleotide binding]; other site
324925001174	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
324925001175	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
324925001176	oligomeric interface; other site
324925001177	putative active site [active]
324925001178	homodimer interface [polypeptide binding]; other site
324925001179	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
324925001180	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
324925001181	FtsX-like permease family; Region: FtsX; pfam02687
324925001182	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
324925001183	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
324925001184	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
324925001185	Walker A/P-loop; other site
324925001186	ATP binding site [chemical binding]; other site
324925001187	Q-loop/lid; other site
324925001188	ABC transporter signature motif; other site
324925001189	Walker B; other site
324925001190	D-loop; other site
324925001191	H-loop/switch region; other site
324925001192	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
324925001193	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
324925001194	active site
324925001195	substrate binding site [chemical binding]; other site
324925001196	metal binding site [ion binding]; metal-binding site
324925001197	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
324925001198	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
324925001199	RuvA N terminal domain; Region: RuvA_N; pfam01330
324925001200	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
324925001201	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
324925001202	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
324925001203	transcription termination factor Rho; Provisional; Region: rho; PRK09376
324925001204	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
324925001205	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
324925001206	RNA binding site [nucleotide binding]; other site
324925001207	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
324925001208	multimer interface [polypeptide binding]; other site
324925001209	Walker A motif; other site
324925001210	ATP binding site [chemical binding]; other site
324925001211	Walker B motif; other site
324925001212	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
324925001213	Ligand binding site [chemical binding]; other site
324925001214	Electron transfer flavoprotein domain; Region: ETF; pfam01012
324925001215	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
324925001216	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
324925001217	Ligand Binding Site [chemical binding]; other site
324925001218	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
324925001219	Bifunctional nuclease; Region: DNase-RNase; pfam02577
324925001220	UvrB/uvrC motif; Region: UVR; pfam02151
324925001221	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
324925001222	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
324925001223	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
324925001224	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
324925001225	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
324925001226	Surface antigen; Region: Bac_surface_Ag; pfam01103
324925001227	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
324925001228	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
324925001229	catalytic residue [active]
324925001230	putative FPP diphosphate  binding site; other site
324925001231	putative FPP binding hydrophobic cleft; other site
324925001232	dimer interface [polypeptide binding]; other site
324925001233	putative IPP diphosphate binding site; other site
324925001234	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
324925001235	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
324925001236	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
324925001237	CoA binding domain; Region: CoA_binding; smart00881
324925001238	CoA-ligase; Region: Ligase_CoA; pfam00549
324925001239	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
324925001240	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
324925001241	putative active site [active]
324925001242	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
324925001243	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
324925001244	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
324925001245	Heavy-metal resistance; Region: Metal_resist; pfam13801
324925001246	dimer interface [polypeptide binding]; other site
324925001247	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
324925001248	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
324925001249	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
324925001250	DNA binding residues [nucleotide binding]
324925001251	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
324925001252	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
324925001253	active site
324925001254	substrate binding site [chemical binding]; other site
324925001255	metal binding site [ion binding]; metal-binding site
324925001256	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
324925001257	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
324925001258	adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854
324925001259	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925001260	TPR motif; other site
324925001261	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925001262	binding surface
324925001263	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925001264	binding surface
324925001265	TPR motif; other site
324925001266	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925001267	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925001268	binding surface
324925001269	TPR motif; other site
324925001270	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925001271	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925001272	binding surface
324925001273	TPR motif; other site
324925001274	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925001275	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925001276	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925001277	TPR motif; other site
324925001278	binding surface
324925001279	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925001280	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925001281	binding surface
324925001282	TPR motif; other site
324925001283	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925001284	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925001285	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925001286	binding surface
324925001287	TPR motif; other site
324925001288	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925001289	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925001290	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925001291	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925001292	binding surface
324925001293	TPR motif; other site
324925001294	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925001295	putative NADPH-dependent glutamate synthase small subunit; Provisional; Region: PRK12814
324925001296	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
324925001297	catalytic loop [active]
324925001298	iron binding site [ion binding]; other site
324925001299	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
324925001300	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
324925001301	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
324925001302	LytB protein; Region: LYTB; cl00507
324925001303	glutamate racemase; Provisional; Region: PRK00865
324925001304	GTP-binding protein YchF; Reviewed; Region: PRK09601
324925001305	YchF GTPase; Region: YchF; cd01900
324925001306	G1 box; other site
324925001307	GTP/Mg2+ binding site [chemical binding]; other site
324925001308	Switch I region; other site
324925001309	G2 box; other site
324925001310	Switch II region; other site
324925001311	G3 box; other site
324925001312	G4 box; other site
324925001313	G5 box; other site
324925001314	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
324925001315	cytidylate kinase; Provisional; Region: cmk; PRK00023
324925001316	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
324925001317	CMP-binding site; other site
324925001318	The sites determining sugar specificity; other site
324925001319	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
324925001320	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
324925001321	RNA binding site [nucleotide binding]; other site
324925001322	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
324925001323	RNA binding site [nucleotide binding]; other site
324925001324	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
324925001325	RNA binding site [nucleotide binding]; other site
324925001326	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
324925001327	RNA binding site [nucleotide binding]; other site
324925001328	S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690
324925001329	RNA binding site [nucleotide binding]; other site
324925001330	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164
324925001331	RNA binding site [nucleotide binding]; other site
324925001332	Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473
324925001333	catalytic triad [active]
324925001334	putative active site [active]
324925001335	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
324925001336	GTPase Era; Reviewed; Region: era; PRK00089
324925001337	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
324925001338	G1 box; other site
324925001339	GTP/Mg2+ binding site [chemical binding]; other site
324925001340	Switch I region; other site
324925001341	G2 box; other site
324925001342	Switch II region; other site
324925001343	G3 box; other site
324925001344	G4 box; other site
324925001345	G5 box; other site
324925001346	KH domain; Region: KH_2; pfam07650
324925001347	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
324925001348	Prominin; Region: Prominin; pfam05478
324925001349	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
324925001350	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
324925001351	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
324925001352	active site
324925001353	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
324925001354	IHF dimer interface [polypeptide binding]; other site
324925001355	IHF - DNA interface [nucleotide binding]; other site
324925001356	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
324925001357	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
324925001358	Walker B motif; other site
324925001359	arginine finger; other site
324925001360	Peptidase family M41; Region: Peptidase_M41; pfam01434
324925001361	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
324925001362	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
324925001363	active site
324925001364	HIGH motif; other site
324925001365	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
324925001366	active site
324925001367	KMSKS motif; other site
324925001368	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
324925001369	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
324925001370	Cytochrome B6-F complex Fe-S subunit; Region: CytB6-F_Fe-S; pfam08802
324925001371	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
324925001372	iron-sulfur cluster [ion binding]; other site
324925001373	[2Fe-2S] cluster binding site [ion binding]; other site
324925001374	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
324925001375	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
324925001376	intrachain domain interface; other site
324925001377	interchain domain interface [polypeptide binding]; other site
324925001378	heme bL binding site [chemical binding]; other site
324925001379	heme bH binding site [chemical binding]; other site
324925001380	Qo binding site; other site
324925001381	intrachain domain interface; other site
324925001382	Qi binding site; other site
324925001383	interchain domain interface [polypeptide binding]; other site
324925001384	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193
324925001385	Qo binding site; other site
324925001386	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
324925001387	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
324925001388	active site
324925001389	catalytic site [active]
324925001390	Bacterial protein of unknown function (DUF883); Region: DUF883; cl01888
324925001391	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK12825
324925001392	classical (c) SDRs; Region: SDR_c; cd05233
324925001393	NAD(P) binding site [chemical binding]; other site
324925001394	active site
324925001395	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
324925001396	molybdenum ABC transporter, ATP-binding protein; Region: modC_ABC; TIGR02142
324925001397	Walker A/P-loop; other site
324925001398	ATP binding site [chemical binding]; other site
324925001399	Q-loop/lid; other site
324925001400	ABC transporter signature motif; other site
324925001401	Walker B; other site
324925001402	D-loop; other site
324925001403	H-loop/switch region; other site
324925001404	TOBE domain; Region: TOBE; cl01440
324925001405	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
324925001406	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
324925001407	putative PBP binding loops; other site
324925001408	ABC-ATPase subunit interface; other site
324925001409	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
324925001410	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
324925001411	putative molybdenum utilization protein ModD; Region: modD; TIGR01334
324925001412	ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573
324925001413	dimerization interface [polypeptide binding]; other site
324925001414	active site
324925001415	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
324925001416	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
324925001417	Walker A/P-loop; other site
324925001418	ATP binding site [chemical binding]; other site
324925001419	Q-loop/lid; other site
324925001420	ABC transporter signature motif; other site
324925001421	Walker B; other site
324925001422	D-loop; other site
324925001423	H-loop/switch region; other site
324925001424	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
324925001425	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
324925001426	TM-ABC transporter signature motif; other site
324925001427	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
324925001428	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
324925001429	Walker A/P-loop; other site
324925001430	ATP binding site [chemical binding]; other site
324925001431	Q-loop/lid; other site
324925001432	ABC transporter signature motif; other site
324925001433	Walker B; other site
324925001434	D-loop; other site
324925001435	H-loop/switch region; other site
324925001436	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
324925001437	TM-ABC transporter signature motif; other site
324925001438	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
324925001439	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_2; cd06335
324925001440	putative ligand binding site [chemical binding]; other site
324925001441	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
324925001442	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
324925001443	Walker A/P-loop; other site
324925001444	ATP binding site [chemical binding]; other site
324925001445	Q-loop/lid; other site
324925001446	ABC transporter signature motif; other site
324925001447	Walker B; other site
324925001448	D-loop; other site
324925001449	H-loop/switch region; other site
324925001450	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
324925001451	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
324925001452	nucleotide binding pocket [chemical binding]; other site
324925001453	K-X-D-G motif; other site
324925001454	catalytic site [active]
324925001455	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
324925001456	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
324925001457	Helix-hairpin-helix motif; Region: HHH; pfam00633
324925001458	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
324925001459	Dimer interface [polypeptide binding]; other site
324925001460	BRCT sequence motif; other site
324925001461	VanZ like family; Region: VanZ; cl01971
324925001462	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
324925001463	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
324925001464	S-adenosylmethionine binding site [chemical binding]; other site
324925001465	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
324925001466	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
324925001467	HlyD family secretion protein; Region: HlyD_3; pfam13437
324925001468	Ferrochelatase; Region: Ferrochelatase; pfam00762
324925001469	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
324925001470	C-terminal domain interface [polypeptide binding]; other site
324925001471	active site
324925001472	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
324925001473	active site
324925001474	N-terminal domain interface [polypeptide binding]; other site
324925001475	Uncharacterized conserved protein [Function unknown]; Region: COG1432
324925001476	LabA_like proteins; Region: LabA; cd10911
324925001477	putative metal binding site [ion binding]; other site
324925001478	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
324925001479	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
324925001480	Walker A/P-loop; other site
324925001481	ATP binding site [chemical binding]; other site
324925001482	Q-loop/lid; other site
324925001483	ABC transporter signature motif; other site
324925001484	Walker B; other site
324925001485	D-loop; other site
324925001486	H-loop/switch region; other site
324925001487	Cobalt transport protein; Region: CbiQ; cl00463
324925001488	cobalt transport protein CbiM; Validated; Region: PRK06265
324925001489	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
324925001490	PDGLE domain; Region: PDGLE; pfam13190
324925001491	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
324925001492	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
324925001493	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
324925001494	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
324925001495	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
324925001496	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
324925001497	FAD binding pocket [chemical binding]; other site
324925001498	FAD binding motif [chemical binding]; other site
324925001499	phosphate binding motif [ion binding]; other site
324925001500	beta-alpha-beta structure motif; other site
324925001501	NAD binding pocket [chemical binding]; other site
324925001502	Iron coordination center [ion binding]; other site
324925001503	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181
324925001504	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
324925001505	putative active site [active]
324925001506	oxyanion strand; other site
324925001507	catalytic triad [active]
324925001508	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
324925001509	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
324925001510	catalytic residues [active]
324925001511	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
324925001512	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
324925001513	RNA binding surface [nucleotide binding]; other site
324925001514	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
324925001515	active site
324925001516	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
324925001517	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
324925001518	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
324925001519	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
324925001520	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
324925001521	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
324925001522	aminodeoxychorismate synthase; Provisional; Region: PRK07508
324925001523	chorismate binding enzyme; Region: Chorismate_bind; cl10555
324925001524	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
324925001525	homodimer interface [polypeptide binding]; other site
324925001526	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224
324925001527	substrate-cofactor binding pocket; other site
324925001528	pyridoxal 5'-phosphate binding site [chemical binding]; other site
324925001529	catalytic residue [active]
324925001530	Aminodeoxychorismate lyase [Coenzyme transport and metabolism]; Region: COG1559
324925001531	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
324925001532	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
324925001533	minor groove reading motif; other site
324925001534	helix-hairpin-helix signature motif; other site
324925001535	substrate binding pocket [chemical binding]; other site
324925001536	active site
324925001537	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
324925001538	putative RNA binding site [nucleotide binding]; other site
324925001539	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
324925001540	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
324925001541	motif II; other site
324925001542	Transposase IS200 like; Region: Y1_Tnp; cl00848
324925001543	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
324925001544	dihydropteroate synthase; Region: DHPS; TIGR01496
324925001545	substrate binding pocket [chemical binding]; other site
324925001546	dimer interface [polypeptide binding]; other site
324925001547	inhibitor binding site; inhibition site
324925001548	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
324925001549	Peptidase family M50; Region: Peptidase_M50; pfam02163
324925001550	active site
324925001551	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
324925001552	putative substrate binding region [chemical binding]; other site
324925001553	Haem-binding domain; Region: Haem_bd; pfam14376
324925001554	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
324925001555	Tandem repeat subunit of reelin and related proteins; Region: Reelin_subrepeat_like; cl15240
324925001556	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
324925001557	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
324925001558	FeS/SAM binding site; other site
324925001559	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
324925001560	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
324925001561	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
324925001562	ATP binding site [chemical binding]; other site
324925001563	putative Mg++ binding site [ion binding]; other site
324925001564	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
324925001565	nucleotide binding region [chemical binding]; other site
324925001566	ATP-binding site [chemical binding]; other site
324925001567	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
324925001568	HRDC domain; Region: HRDC; pfam00570
324925001569	antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870
324925001570	Zn binding site [ion binding]; other site
324925001571	toxin interface [polypeptide binding]; other site
324925001572	Uncharacterized protein family (UPF0175); Region: UPF0175; cl01085
324925001573	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
324925001574	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
324925001575	Chain length determinant protein; Region: Wzz; cl15801
324925001576	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
324925001577	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
324925001578	Nucleotide binding site [chemical binding]; other site
324925001579	DTAP/Switch II; other site
324925001580	Switch I; other site
324925001581	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
324925001582	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
324925001583	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
324925001584	NAD(P) binding site [chemical binding]; other site
324925001585	homodimer interface [polypeptide binding]; other site
324925001586	substrate binding site [chemical binding]; other site
324925001587	active site
324925001588	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
324925001589	active site
324925001590	NTP binding site [chemical binding]; other site
324925001591	metal binding triad [ion binding]; metal-binding site
324925001592	antibiotic binding site [chemical binding]; other site
324925001593	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
324925001594	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
324925001595	Walker A/P-loop; other site
324925001596	ATP binding site [chemical binding]; other site
324925001597	Q-loop/lid; other site
324925001598	ABC transporter signature motif; other site
324925001599	Walker B; other site
324925001600	D-loop; other site
324925001601	H-loop/switch region; other site
324925001602	Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257
324925001603	NAD dependent epimerase/dehydratase, LLPSF_EDH_00030 family; Region: EDH_00030; TIGR04180
324925001604	NAD binding site [chemical binding]; other site
324925001605	substrate binding site [chemical binding]; other site
324925001606	active site
324925001607	aminotransferase, LLPSF_NHT_00031 family; Region: NHT_00031; TIGR04181
324925001608	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
324925001609	inhibitor-cofactor binding pocket; inhibition site
324925001610	pyridoxal 5'-phosphate binding site [chemical binding]; other site
324925001611	catalytic residue [active]
324925001612	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
324925001613	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
324925001614	putative trimer interface [polypeptide binding]; other site
324925001615	putative CoA binding site [chemical binding]; other site
324925001616	N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569
324925001617	NeuB family; Region: NeuB; pfam03102
324925001618	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
324925001619	NeuB binding interface [polypeptide binding]; other site
324925001620	putative substrate binding site [chemical binding]; other site
324925001621	UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568
324925001622	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
324925001623	active site
324925001624	homodimer interface [polypeptide binding]; other site
324925001625	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain associated with the NTP (Nucleotidyl transferase) domain downstream. CBS is a small domain originally identified in cystathionine beta-synthase and subsequently...; Region: CBS_pair_NTP_transferase_assoc; cd04607
324925001626	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
324925001627	NTP_trnasferase_like_2 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_2; cd06426
324925001628	Substrate binding site; other site
324925001629	metal-binding site
324925001630	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_III; cd01996
324925001631	Ligand Binding Site [chemical binding]; other site
324925001632	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
324925001633	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
324925001634	substrate binding site [chemical binding]; other site
324925001635	glutamase interaction surface [polypeptide binding]; other site
324925001636	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
324925001637	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
324925001638	putative active site [active]
324925001639	oxyanion strand; other site
324925001640	catalytic triad [active]
324925001641	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
324925001642	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
324925001643	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
324925001644	ligand binding site; other site
324925001645	tetramer interface; other site
324925001646	flagellin modification protein A; Provisional; Region: PRK09186
324925001647	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
324925001648	NAD(P) binding site [chemical binding]; other site
324925001649	active site
324925001650	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
324925001651	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
324925001652	trimer interface [polypeptide binding]; other site
324925001653	active site
324925001654	substrate binding site [chemical binding]; other site
324925001655	CoA binding site [chemical binding]; other site
324925001656	Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387
324925001657	Winged helix-turn helix; Region: HTH_29; pfam13551
324925001658	Homeodomain-like domain; Region: HTH_23; cl17451
324925001659	Homeodomain-like domain; Region: HTH_32; pfam13565
324925001660	DDE superfamily endonuclease; Region: DDE_3; pfam13358
324925001661	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
324925001662	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
324925001663	GDP-fucose protein O-fucosyltransferase and related proteins; Region: O-FucT_like; cl16914
324925001664	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
324925001665	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
324925001666	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
324925001667	UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130
324925001668	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
324925001669	NAD(P) binding site [chemical binding]; other site
324925001670	homodimer interface [polypeptide binding]; other site
324925001671	substrate binding site [chemical binding]; other site
324925001672	active site
324925001673	Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485
324925001674	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
324925001675	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
324925001676	NAD(P) binding site [chemical binding]; other site
324925001677	active site
324925001678	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
324925001679	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
324925001680	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
324925001681	active site
324925001682	homodimer interface [polypeptide binding]; other site
324925001683	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
324925001684	putative trimer interface [polypeptide binding]; other site
324925001685	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
324925001686	putative CoA binding site [chemical binding]; other site
324925001687	putative acyl transferase; Provisional; Region: PRK10502
324925001688	wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825
324925001689	putative trimer interface [polypeptide binding]; other site
324925001690	putative active site [active]
324925001691	putative substrate binding site [chemical binding]; other site
324925001692	putative CoA binding site [chemical binding]; other site
324925001693	Methyltransferase domain; Region: Methyltransf_23; pfam13489
324925001694	Methyltransferase domain; Region: Methyltransf_18; pfam12847
324925001695	Methyltransferase domain; Region: Methyltransf_23; pfam13489
324925001696	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
324925001697	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
324925001698	putative metal binding site; other site
324925001699	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
324925001700	WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433
324925001701	metal-binding site
324925001702	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
324925001703	UDP-glucose 4 epimerase, subgroup 4, extended (e) SDRs; Region: UDP_G4E_4_SDR_e; cd05232
324925001704	putative NAD(P) binding site [chemical binding]; other site
324925001705	active site
324925001706	putative substrate binding site [chemical binding]; other site
324925001707	Bacterial sugar transferase; Region: Bac_transf; pfam02397
324925001708	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
324925001709	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
324925001710	NADP binding site [chemical binding]; other site
324925001711	active site
324925001712	putative substrate binding site [chemical binding]; other site
324925001713	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
324925001714	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
324925001715	NADP-binding site; other site
324925001716	homotetramer interface [polypeptide binding]; other site
324925001717	substrate binding site [chemical binding]; other site
324925001718	homodimer interface [polypeptide binding]; other site
324925001719	active site
324925001720	Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360
324925001721	sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570
324925001722	putative trimer interface [polypeptide binding]; other site
324925001723	putative CoA binding site [chemical binding]; other site
324925001724	putative glycosyl transferase; Provisional; Region: PRK10307
324925001725	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
324925001726	Bacterial sugar transferase; Region: Bac_transf; pfam02397
324925001727	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
324925001728	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
324925001729	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
324925001730	acyl-activating enzyme (AAE) consensus motif; other site
324925001731	AMP binding site [chemical binding]; other site
324925001732	active site
324925001733	CoA binding site [chemical binding]; other site
324925001734	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
324925001735	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
324925001736	NAD(P) binding site [chemical binding]; other site
324925001737	active site
324925001738	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
324925001739	trimer interface [polypeptide binding]; other site
324925001740	active site
324925001741	substrate binding site [chemical binding]; other site
324925001742	CoA binding site [chemical binding]; other site
324925001743	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
324925001744	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
324925001745	inhibitor-cofactor binding pocket; inhibition site
324925001746	pyridoxal 5'-phosphate binding site [chemical binding]; other site
324925001747	catalytic residue [active]
324925001748	Protein of unknown function (DUF3485); Region: DUF3485; pfam11984
324925001749	Predicted membrane protein [Function unknown]; Region: COG4083; cl15694
324925001750	Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721
324925001751	peptidyl-prolyl cis-trans isomerase, EpsD family; Region: cis_trans_EpsD; TIGR02925
324925001752	SurA N-terminal domain; Region: SurA_N_3; cl07813
324925001753	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
324925001754	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
324925001755	NADP-binding site; other site
324925001756	homotetramer interface [polypeptide binding]; other site
324925001757	substrate binding site [chemical binding]; other site
324925001758	homodimer interface [polypeptide binding]; other site
324925001759	active site
324925001760	Protein of unknown function (DUF2283); Region: DUF2283; pfam10049
324925001761	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
324925001762	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
324925001763	non-specific DNA binding site [nucleotide binding]; other site
324925001764	salt bridge; other site
324925001765	sequence-specific DNA binding site [nucleotide binding]; other site
324925001766	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
324925001767	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
324925001768	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
324925001769	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
324925001770	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
324925001771	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
324925001772	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
324925001773	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
324925001774	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
324925001775	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
324925001776	non-specific DNA binding site [nucleotide binding]; other site
324925001777	salt bridge; other site
324925001778	sequence-specific DNA binding site [nucleotide binding]; other site
324925001779	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
324925001780	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
324925001781	non-specific DNA binding site [nucleotide binding]; other site
324925001782	salt bridge; other site
324925001783	sequence-specific DNA binding site [nucleotide binding]; other site
324925001784	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
324925001785	putative active site [active]
324925001786	homotetramer interaction site [polypeptide binding]; other site
324925001787	homodimer interaction site [polypeptide binding]; other site
324925001788	legume lectins; Region: lectin_L-type; cl14058
324925001789	carbohydrate binding site [chemical binding]; other site
324925001790	metal binding site [ion binding]; metal-binding site
324925001791	PEP-CTERM motif; Region: VPEP; pfam07589
324925001792	PEP-CTERM motif; Region: VPEP; pfam07589
324925001793	DDE superfamily endonuclease; Region: DDE_3; pfam13358
324925001794	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
324925001795	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
324925001796	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
324925001797	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
324925001798	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
324925001799	Putative addiction module component; Region: Unstab_antitox; pfam09720
324925001800	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
324925001801	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
324925001802	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
324925001803	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
324925001804	Uncharacterized conserved protein [Function unknown]; Region: COG1434
324925001805	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
324925001806	putative active site [active]
324925001807	transcriptional activator RfaH; Region: RfaH; TIGR01955
324925001808	N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766
324925001809	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
324925001810	heterodimer interface [polypeptide binding]; other site
324925001811	homodimer interface [polypeptide binding]; other site
324925001812	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
324925001813	D-galactonate transporter; Region: 2A0114; TIGR00893
324925001814	putative substrate translocation pore; other site
324925001815	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
324925001816	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
324925001817	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
324925001818	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
324925001819	pyruvate phosphate dikinase; Provisional; Region: PRK09279
324925001820	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
324925001821	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
324925001822	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
324925001823	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
324925001824	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
324925001825	TM-ABC transporter signature motif; other site
324925001826	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
324925001827	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
324925001828	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
324925001829	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
324925001830	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
324925001831	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
324925001832	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
324925001833	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
324925001834	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
324925001835	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
324925001836	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
324925001837	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
324925001838	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
324925001839	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
324925001840	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
324925001841	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
324925001842	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
324925001843	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
324925001844	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
324925001845	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
324925001846	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
324925001847	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
324925001848	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
324925001849	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
324925001850	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
324925001851	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
324925001852	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
324925001853	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
324925001854	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
324925001855	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
324925001856	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
324925001857	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
324925001858	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
324925001859	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
324925001860	ligand binding site [chemical binding]; other site
324925001861	flexible hinge region; other site
324925001862	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
324925001863	Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259
324925001864	putative active site [active]
324925001865	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
324925001866	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
324925001867	Walker A/P-loop; other site
324925001868	ATP binding site [chemical binding]; other site
324925001869	Q-loop/lid; other site
324925001870	ABC transporter signature motif; other site
324925001871	Walker B; other site
324925001872	D-loop; other site
324925001873	H-loop/switch region; other site
324925001874	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
324925001875	HlyD family secretion protein; Region: HlyD_3; pfam13437
324925001876	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
324925001877	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925001878	binding surface
324925001879	TPR motif; other site
324925001880	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925001881	binding surface
324925001882	TPR motif; other site
324925001883	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
324925001884	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925001885	binding surface
324925001886	TPR motif; other site
324925001887	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925001888	binding surface
324925001889	TPR motif; other site
324925001890	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
324925001891	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925001892	binding surface
324925001893	TPR motif; other site
324925001894	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925001895	binding surface
324925001896	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
324925001897	TPR motif; other site
324925001898	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925001899	binding surface
324925001900	TPR motif; other site
324925001901	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
324925001902	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925001903	TPR motif; other site
324925001904	binding surface
324925001905	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925001906	binding surface
324925001907	TPR motif; other site
324925001908	TPR repeat; Region: TPR_11; pfam13414
324925001909	TPR repeat; Region: TPR_11; pfam13414
324925001910	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925001911	binding surface
324925001912	TPR motif; other site
324925001913	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
324925001914	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925001915	binding surface
324925001916	TPR repeat; Region: TPR_11; pfam13414
324925001917	TPR motif; other site
324925001918	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
324925001919	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
324925001920	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925001921	TPR motif; other site
324925001922	binding surface
324925001923	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925001924	binding surface
324925001925	TPR motif; other site
324925001926	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925001927	binding surface
324925001928	TPR motif; other site
324925001929	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
324925001930	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925001931	binding surface
324925001932	TPR motif; other site
324925001933	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
324925001934	Tetratricopeptide repeat; Region: TPR_16; pfam13432
324925001935	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925001936	binding surface
324925001937	TPR motif; other site
324925001938	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
324925001939	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925001940	binding surface
324925001941	TPR motif; other site
324925001942	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925001943	binding surface
324925001944	TPR motif; other site
324925001945	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
324925001946	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925001947	binding surface
324925001948	TPR motif; other site
324925001949	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925001950	binding surface
324925001951	TPR motif; other site
324925001952	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
324925001953	active site
324925001954	Methyltransferase FkbM domain; Region: Methyltransf_21; cl17387
324925001955	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925001956	binding surface
324925001957	TPR motif; other site
324925001958	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
324925001959	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925001960	binding surface
324925001961	TPR motif; other site
324925001962	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925001963	binding surface
324925001964	TPR motif; other site
324925001965	Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914
324925001966	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925001967	binding surface
324925001968	TPR motif; other site
324925001969	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925001970	binding surface
324925001971	TPR motif; other site
324925001972	Methyltransferase domain; Region: Methyltransf_23; pfam13489
324925001973	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
324925001974	S-adenosylmethionine binding site [chemical binding]; other site
324925001975	Isochorismatase family; Region: Isochorismatase; pfam00857
324925001976	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
324925001977	catalytic triad [active]
324925001978	dimer interface [polypeptide binding]; other site
324925001979	conserved cis-peptide bond; other site
324925001980	Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606
324925001981	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
324925001982	putative acyl-acceptor binding pocket; other site
324925001983	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
324925001984	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
324925001985	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
324925001986	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
324925001987	Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding); Region: MPN_like; cd08070
324925001988	MPN+ (JAMM) motif; other site
324925001989	Zinc-binding site [ion binding]; other site
324925001990	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
324925001991	Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458
324925001992	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
324925001993	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
324925001994	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
324925001995	active site
324925001996	ribulose/triose binding site [chemical binding]; other site
324925001997	phosphate binding site [ion binding]; other site
324925001998	substrate (anthranilate) binding pocket [chemical binding]; other site
324925001999	product (indole) binding pocket [chemical binding]; other site
324925002000	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
324925002001	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
324925002002	substrate binding site [chemical binding]; other site
324925002003	hexamer interface [polypeptide binding]; other site
324925002004	metal binding site [ion binding]; metal-binding site
324925002005	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
324925002006	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
324925002007	Surface antigen; Region: Bac_surface_Ag; pfam01103
324925002008	Protein of unknown function (DUF2795); Region: DUF2795; pfam11387
324925002009	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
324925002010	Peptidase family M23; Region: Peptidase_M23; pfam01551
324925002011	DNA polymerase I; Provisional; Region: PRK05755
324925002012	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
324925002013	active site
324925002014	metal binding site 1 [ion binding]; metal-binding site
324925002015	putative 5' ssDNA interaction site; other site
324925002016	metal binding site 3; metal-binding site
324925002017	metal binding site 2 [ion binding]; metal-binding site
324925002018	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
324925002019	putative DNA binding site [nucleotide binding]; other site
324925002020	putative metal binding site [ion binding]; other site
324925002021	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
324925002022	active site
324925002023	catalytic site [active]
324925002024	substrate binding site [chemical binding]; other site
324925002025	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
324925002026	active site
324925002027	DNA binding site [nucleotide binding]
324925002028	catalytic site [active]
324925002029	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
324925002030	Prephenate dehydratase; Region: PDT; pfam00800
324925002031	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
324925002032	putative L-Phe binding site [chemical binding]; other site
324925002033	hypothetical protein; Validated; Region: PRK00110
324925002034	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
324925002035	active site
324925002036	putative DNA-binding cleft [nucleotide binding]; other site
324925002037	dimer interface [polypeptide binding]; other site
324925002038	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
324925002039	bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188
324925002040	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
324925002041	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
324925002042	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
324925002043	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
324925002044	active site
324925002045	dimerization interface [polypeptide binding]; other site
324925002046	TspO/MBR family; Region: TspO_MBR; pfam03073
324925002047	Domain of unknown function (DUF4405); Region: DUF4405; pfam14358
324925002048	acetyl-CoA synthetase; Provisional; Region: PRK00174
324925002049	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
324925002050	active site
324925002051	CoA binding site [chemical binding]; other site
324925002052	acyl-activating enzyme (AAE) consensus motif; other site
324925002053	AMP binding site [chemical binding]; other site
324925002054	acetate binding site [chemical binding]; other site
324925002055	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
324925002056	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
324925002057	HIGH motif; other site
324925002058	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
324925002059	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
324925002060	active site
324925002061	KMSKS motif; other site
324925002062	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
324925002063	tRNA binding surface [nucleotide binding]; other site
324925002064	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
324925002065	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
324925002066	RNase E interface [polypeptide binding]; other site
324925002067	trimer interface [polypeptide binding]; other site
324925002068	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
324925002069	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
324925002070	RNase E interface [polypeptide binding]; other site
324925002071	trimer interface [polypeptide binding]; other site
324925002072	active site
324925002073	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
324925002074	putative nucleic acid binding region [nucleotide binding]; other site
324925002075	G-X-X-G motif; other site
324925002076	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
324925002077	RNA binding site [nucleotide binding]; other site
324925002078	domain interface; other site
324925002079	Pantoate-beta-alanine ligase; Region: PanC; cd00560
324925002080	pantoate--beta-alanine ligase; Region: panC; TIGR00018
324925002081	active site
324925002082	ATP-binding site [chemical binding]; other site
324925002083	pantoate-binding site; other site
324925002084	HXXH motif; other site
324925002085	Predicted methyltransferases [General function prediction only]; Region: COG0313
324925002086	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
324925002087	putative SAM binding site [chemical binding]; other site
324925002088	putative homodimer interface [polypeptide binding]; other site
324925002089	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
324925002090	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
324925002091	Walker A/P-loop; other site
324925002092	ATP binding site [chemical binding]; other site
324925002093	Q-loop/lid; other site
324925002094	ABC transporter signature motif; other site
324925002095	Walker B; other site
324925002096	D-loop; other site
324925002097	H-loop/switch region; other site
324925002098	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
324925002099	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
324925002100	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
324925002101	tandem repeat interface [polypeptide binding]; other site
324925002102	oligomer interface [polypeptide binding]; other site
324925002103	active site residues [active]
324925002104	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
324925002105	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
324925002106	tandem repeat interface [polypeptide binding]; other site
324925002107	oligomer interface [polypeptide binding]; other site
324925002108	active site residues [active]
324925002109	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
324925002110	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
324925002111	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
324925002112	Walker A motif; other site
324925002113	ATP binding site [chemical binding]; other site
324925002114	Walker B motif; other site
324925002115	arginine finger; other site
324925002116	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
324925002117	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
324925002118	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
324925002119	DNA methylase; Region: N6_N4_Mtase; pfam01555
324925002120	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
324925002121	S-adenosylmethionine binding site [chemical binding]; other site
324925002122	Staphylococcal nuclease homologues; Region: SNc; smart00318
324925002123	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
324925002124	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
324925002125	cofactor binding site; other site
324925002126	DNA binding site [nucleotide binding]
324925002127	substrate interaction site [chemical binding]; other site
324925002128	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
324925002129	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
324925002130	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
324925002131	active site
324925002132	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
324925002133	Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418
324925002134	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
324925002135	Photosystem P840 reaction-centre cytochrome c-551; Region: Cytochrome-c551; pfam10643
324925002136	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
324925002137	active site
324925002138	Putative methyltransferase; Region: Methyltransf_16; pfam10294
324925002139	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
324925002140	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
324925002141	active site
324925002142	DNA binding site [nucleotide binding]
324925002143	Int/Topo IB signature motif; other site
324925002144	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
324925002145	30S subunit binding site; other site
324925002146	HPr kinase/phosphorylase; Provisional; Region: PRK05428
324925002147	HPr Serine kinase N terminus; Region: Hpr_kinase_N; pfam02603
324925002148	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
324925002149	Hpr binding site; other site
324925002150	active site
324925002151	homohexamer subunit interaction site [polypeptide binding]; other site
324925002152	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
324925002153	The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514
324925002154	peptide binding site [polypeptide binding]; other site
324925002155	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
324925002156	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
324925002157	dimer interface [polypeptide binding]; other site
324925002158	conserved gate region; other site
324925002159	putative PBP binding loops; other site
324925002160	ABC-ATPase subunit interface; other site
324925002161	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
324925002162	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
324925002163	Walker A motif; other site
324925002164	ATP binding site [chemical binding]; other site
324925002165	Walker B motif; other site
324925002166	arginine finger; other site
324925002167	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
324925002168	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925002169	TPR motif; other site
324925002170	binding surface
324925002171	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925002172	TPR motif; other site
324925002173	binding surface
324925002174	FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457
324925002175	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
324925002176	binding surface
324925002177	TPR motif; other site
324925002178	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925002179	TPR motif; other site
324925002180	binding surface
324925002181	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
324925002182	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
324925002183	dimer interface [polypeptide binding]; other site
324925002184	PYR/PP interface [polypeptide binding]; other site
324925002185	TPP binding site [chemical binding]; other site
324925002186	substrate binding site [chemical binding]; other site
324925002187	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
324925002188	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
324925002189	Domain of unknown function; Region: EKR; pfam10371
324925002190	4Fe-4S binding domain; Region: Fer4_6; pfam12837
324925002191	4Fe-4S binding domain; Region: Fer4; pfam00037
324925002192	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
324925002193	TPP-binding site [chemical binding]; other site
324925002194	dimer interface [polypeptide binding]; other site
324925002195	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
324925002196	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
324925002197	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
324925002198	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
324925002199	lipoyl attachment site [posttranslational modification]; other site
324925002200	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
324925002201	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
324925002202	tetramer interface [polypeptide binding]; other site
324925002203	pyridoxal 5'-phosphate binding site [chemical binding]; other site
324925002204	catalytic residue [active]
324925002205	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
324925002206	dihydrodipicolinate synthase; Region: dapA; TIGR00674
324925002207	dimer interface [polypeptide binding]; other site
324925002208	active site
324925002209	catalytic residue [active]
324925002210	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
324925002211	PAS fold; Region: PAS_3; pfam08447
324925002212	putative active site [active]
324925002213	heme pocket [chemical binding]; other site
324925002214	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
324925002215	PAS fold; Region: PAS_3; pfam08447
324925002216	putative active site [active]
324925002217	heme pocket [chemical binding]; other site
324925002218	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
324925002219	GAF domain; Region: GAF; pfam01590
324925002220	GAF domain; Region: GAF_2; pfam13185
324925002221	GAF domain; Region: GAF; pfam01590
324925002222	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
324925002223	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
324925002224	putative active site [active]
324925002225	heme pocket [chemical binding]; other site
324925002226	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
324925002227	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
324925002228	putative active site [active]
324925002229	heme pocket [chemical binding]; other site
324925002230	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
324925002231	putative active site [active]
324925002232	heme pocket [chemical binding]; other site
324925002233	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
324925002234	dimer interface [polypeptide binding]; other site
324925002235	phosphorylation site [posttranslational modification]
324925002236	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
324925002237	ATP binding site [chemical binding]; other site
324925002238	Mg2+ binding site [ion binding]; other site
324925002239	G-X-G motif; other site
324925002240	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
324925002241	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
324925002242	active site
324925002243	phosphorylation site [posttranslational modification]
324925002244	intermolecular recognition site; other site
324925002245	dimerization interface [polypeptide binding]; other site
324925002246	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
324925002247	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
324925002248	Walker A/P-loop; other site
324925002249	ATP binding site [chemical binding]; other site
324925002250	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
324925002251	ABC transporter signature motif; other site
324925002252	Walker B; other site
324925002253	D-loop; other site
324925002254	H-loop/switch region; other site
324925002255	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
324925002256	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
324925002257	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
324925002258	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
324925002259	Ligand Binding Site [chemical binding]; other site
324925002260	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782
324925002261	RNA/DNA hybrid binding site [nucleotide binding]; other site
324925002262	active site
324925002263	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
324925002264	bacteriochlorophyll/chlorophyll a synthase; Reviewed; Region: PRK07566
324925002265	UbiA prenyltransferase family; Region: UbiA; pfam01040
324925002266	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
324925002267	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
324925002268	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
324925002269	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
324925002270	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
324925002271	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
324925002272	active site
324925002273	CutA1 divalent ion tolerance protein; Region: CutA1; cl00584
324925002274	Homeodomain-like domain; Region: HTH_23; pfam13384
324925002275	Winged helix-turn helix; Region: HTH_29; pfam13551
324925002276	Homeodomain-like domain; Region: HTH_32; pfam13565
324925002277	DDE superfamily endonuclease; Region: DDE_3; pfam13358
324925002278	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
324925002279	Cadherin repeat-like domain; Region: CA_like; cl15786
324925002280	Ca2+ binding site [ion binding]; other site
324925002281	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
324925002282	Ca2+ binding site [ion binding]; other site
324925002283	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
324925002284	Ca2+ binding site [ion binding]; other site
324925002285	Integrin, beta chain; Region: Integrin_beta; cl17693
324925002286	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
324925002287	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
324925002288	Walker A motif; other site
324925002289	ATP binding site [chemical binding]; other site
324925002290	DNA polymerase III subunit delta'; Validated; Region: PRK08485
324925002291	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
324925002292	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
324925002293	homodimer interface [polypeptide binding]; other site
324925002294	substrate-cofactor binding pocket; other site
324925002295	catalytic residue [active]
324925002296	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
324925002297	active site
324925002298	ADP/pyrophosphate binding site [chemical binding]; other site
324925002299	dimerization interface [polypeptide binding]; other site
324925002300	allosteric effector site; other site
324925002301	fructose-1,6-bisphosphate binding site; other site
324925002302	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
324925002303	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
324925002304	FtsX-like permease family; Region: FtsX; pfam02687
324925002305	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
324925002306	homotrimer interaction site [polypeptide binding]; other site
324925002307	zinc binding site [ion binding]; other site
324925002308	CDP-binding sites; other site
324925002309	Domain of unknown function (DUF4407); Region: DUF4407; pfam14362
324925002310	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
324925002311	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
324925002312	heterodimer interface [polypeptide binding]; other site
324925002313	active site
324925002314	FMN binding site [chemical binding]; other site
324925002315	homodimer interface [polypeptide binding]; other site
324925002316	substrate binding site [chemical binding]; other site
324925002317	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
324925002318	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
324925002319	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
324925002320	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
324925002321	active site
324925002322	metal binding site [ion binding]; metal-binding site
324925002323	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
324925002324	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096
324925002325	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
324925002326	Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458
324925002327	ATP-grasp domain; Region: ATP-grasp_4; cl17255
324925002328	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
324925002329	IMP binding site; other site
324925002330	dimer interface [polypeptide binding]; other site
324925002331	interdomain contacts; other site
324925002332	partial ornithine binding site; other site
324925002333	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
324925002334	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
324925002335	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
324925002336	dimerization interface [polypeptide binding]; other site
324925002337	active site
324925002338	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
324925002339	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
324925002340	dimer interface [polypeptide binding]; other site
324925002341	active site
324925002342	glycine-pyridoxal phosphate binding site [chemical binding]; other site
324925002343	folate binding site [chemical binding]; other site
324925002344	DNA primase; Validated; Region: dnaG; PRK05667
324925002345	CHC2 zinc finger; Region: zf-CHC2; pfam01807
324925002346	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
324925002347	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
324925002348	active site
324925002349	metal binding site [ion binding]; metal-binding site
324925002350	interdomain interaction site; other site
324925002351	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
324925002352	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
324925002353	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
324925002354	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
324925002355	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
324925002356	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
324925002357	Protein of unknown function (DUF3098); Region: DUF3098; pfam11297
324925002358	acetylornithine aminotransferase; Provisional; Region: PRK02627
324925002359	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
324925002360	inhibitor-cofactor binding pocket; inhibition site
324925002361	pyridoxal 5'-phosphate binding site [chemical binding]; other site
324925002362	catalytic residue [active]
324925002363	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
324925002364	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
324925002365	putative active site [active]
324925002366	putative metal binding site [ion binding]; other site
324925002367	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
324925002368	NACHT domain; Region: NACHT; pfam05729
324925002369	Uncharacterized conserved protein [Function unknown]; Region: COG1262
324925002370	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
324925002371	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
324925002372	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
324925002373	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
324925002374	AIR carboxylase; Region: AIRC; pfam00731
324925002375	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
324925002376	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
324925002377	FeS/SAM binding site; other site
324925002378	HemN C-terminal domain; Region: HemN_C; pfam06969
324925002379	AAA domain; Region: AAA_21; pfam13304
324925002380	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
324925002381	ABC transporter signature motif; other site
324925002382	Walker B; other site
324925002383	D-loop; other site
324925002384	H-loop/switch region; other site
324925002385	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
324925002386	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
324925002387	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
324925002388	ATP binding site [chemical binding]; other site
324925002389	putative Mg++ binding site [ion binding]; other site
324925002390	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
324925002391	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
324925002392	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
324925002393	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
324925002394	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
324925002395	Zeta toxin; Region: Zeta_toxin; pfam06414
324925002396	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
324925002397	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
324925002398	HsdM N-terminal domain; Region: HsdM_N; pfam12161
324925002399	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
324925002400	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
324925002401	S-adenosylmethionine binding site [chemical binding]; other site
324925002402	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
324925002403	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
324925002404	Sel1-like repeats; Region: SEL1; smart00671
324925002405	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
324925002406	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
324925002407	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
324925002408	putative active site [active]
324925002409	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
324925002410	WHG domain; Region: WHG; pfam13305
324925002411	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
324925002412	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
324925002413	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
324925002414	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
324925002415	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
324925002416	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
324925002417	Triacylglycerol lipase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: Triacylglycerol_lipase_like; cd01847
324925002418	active site
324925002419	catalytic triad [active]
324925002420	oxyanion hole [active]
324925002421	Autotransporter beta-domain; Region: Autotransporter; pfam03797
324925002422	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
324925002423	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
324925002424	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
324925002425	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
324925002426	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
324925002427	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
324925002428	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
324925002429	ABC transporter; Region: ABC_tran_2; pfam12848
324925002430	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
324925002431	YXWGXW repeat (2 copies); Region: YXWGXW; pfam12779
324925002432	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
324925002433	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
324925002434	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
324925002435	HlyD family secretion protein; Region: HlyD_3; pfam13437
324925002436	macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535
324925002437	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
324925002438	Walker A/P-loop; other site
324925002439	ATP binding site [chemical binding]; other site
324925002440	Q-loop/lid; other site
324925002441	ABC transporter signature motif; other site
324925002442	Walker B; other site
324925002443	D-loop; other site
324925002444	H-loop/switch region; other site
324925002445	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
324925002446	FtsX-like permease family; Region: FtsX; pfam02687
324925002447	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
324925002448	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
324925002449	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
324925002450	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
324925002451	putative dimer interface [polypeptide binding]; other site
324925002452	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
324925002453	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
324925002454	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
324925002455	CoA-ligase; Region: Ligase_CoA; pfam00549
324925002456	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
324925002457	nucleoside/Zn binding site; other site
324925002458	dimer interface [polypeptide binding]; other site
324925002459	catalytic motif [active]
324925002460	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
324925002461	FMN binding site [chemical binding]; other site
324925002462	substrate binding site [chemical binding]; other site
324925002463	putative catalytic residue [active]
324925002464	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
324925002465	catalytic core [active]
324925002466	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
324925002467	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
324925002468	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
324925002469	active site
324925002470	dimer interface [polypeptide binding]; other site
324925002471	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
324925002472	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
324925002473	active site
324925002474	FMN binding site [chemical binding]; other site
324925002475	substrate binding site [chemical binding]; other site
324925002476	3Fe-4S cluster binding site [ion binding]; other site
324925002477	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
324925002478	domain interface; other site
324925002479	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
324925002480	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
324925002481	Domain of unknown function (DUF4404); Region: DUF4404; pfam14357
324925002482	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
324925002483	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
324925002484	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
324925002485	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
324925002486	Walker A motif; other site
324925002487	ATP binding site [chemical binding]; other site
324925002488	Walker B motif; other site
324925002489	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
324925002490	Microscilla MS158 and related proteins, metallophosphatase domain; Region: MPP_MS158; cd07404
324925002491	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
324925002492	putative active site [active]
324925002493	putative metal binding site [ion binding]; other site
324925002494	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
324925002495	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
324925002496	AE_Prim_S_like: primase domain similar to that found in the small subunit of archaeal and eukaryotic (A/E) DNA primases. The replication machineries of A/Es are distinct from that of bacteria. Primases are DNA-dependent RNA polymerases which synthesis...; Region: AE_Prim_S_like; cl01287
324925002497	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
324925002498	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
324925002499	ATP binding site [chemical binding]; other site
324925002500	putative Mg++ binding site [ion binding]; other site
324925002501	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
324925002502	nucleotide binding region [chemical binding]; other site
324925002503	ATP-binding site [chemical binding]; other site
324925002504	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
324925002505	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
324925002506	non-specific DNA binding site [nucleotide binding]; other site
324925002507	salt bridge; other site
324925002508	sequence-specific DNA binding site [nucleotide binding]; other site
324925002509	Domain of unknown function (DUF4095); Region: DUF4095; pfam13338
324925002510	Catalytic domain of uncharacterized hypothetical proteins similar to eukaryotic phosphatidylinositol-specific phospholipase C, X domain containing proteins; Region: PI-PLCXDc_like_1; cd08620
324925002511	putative active site [active]
324925002512	catalytic site [active]
324925002513	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
324925002514	Flp/Fap pilin component; Region: Flp_Fap; pfam04964
324925002515	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
324925002516	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
324925002517	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
324925002518	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
324925002519	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
324925002520	Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977
324925002521	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
324925002522	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
324925002523	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
324925002524	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
324925002525	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
324925002526	ATP binding site [chemical binding]; other site
324925002527	Walker A motif; other site
324925002528	hexamer interface [polypeptide binding]; other site
324925002529	Walker B motif; other site
324925002530	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
324925002531	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
324925002532	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
324925002533	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
324925002534	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
324925002535	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
324925002536	FeS/SAM binding site; other site
324925002537	tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407
324925002538	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
324925002539	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
324925002540	S-adenosylmethionine binding site [chemical binding]; other site
324925002541	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
324925002542	Flavocytochrome c sulphide dehydrogenase, flavin-binding; Region: FCSD-flav_bind; pfam09242
324925002543	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
324925002544	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
324925002545	sulfur oxidation protein SoxY; Provisional; Region: PRK07474
324925002546	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
324925002547	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
324925002548	Cytochrome c [Energy production and conversion]; Region: COG3258
324925002549	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
324925002550	Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411
324925002551	active site
324925002552	metal binding site [ion binding]; metal-binding site
324925002553	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
324925002554	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
324925002555	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
324925002556	catalytic residues [active]
324925002557	Rubrerythrin [Energy production and conversion]; Region: COG1592
324925002558	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
324925002559	binuclear metal center [ion binding]; other site
324925002560	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202
324925002561	iron binding site [ion binding]; other site
324925002562	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
324925002563	ABC-type transport system involved in cytochrome bd biosynthesis, fused ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydC; COG4987
324925002564	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
324925002565	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
324925002566	Walker A/P-loop; other site
324925002567	ATP binding site [chemical binding]; other site
324925002568	Q-loop/lid; other site
324925002569	ABC transporter signature motif; other site
324925002570	Walker B; other site
324925002571	D-loop; other site
324925002572	H-loop/switch region; other site
324925002573	thiol reductant ABC exporter, CydD subunit; Region: CydD; TIGR02857
324925002574	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
324925002575	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
324925002576	Walker A/P-loop; other site
324925002577	ATP binding site [chemical binding]; other site
324925002578	Q-loop/lid; other site
324925002579	ABC transporter signature motif; other site
324925002580	Walker B; other site
324925002581	D-loop; other site
324925002582	H-loop/switch region; other site
324925002583	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
324925002584	Plasmid stability protein [General function prediction only]; Region: StbC; COG4691
324925002585	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
324925002586	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
324925002587	pyridoxal 5'-phosphate binding site [chemical binding]; other site
324925002588	catalytic residue [active]
324925002589	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
324925002590	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
324925002591	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
324925002592	catalytic site [active]
324925002593	Rrf2 family protein; Region: rrf2_super; TIGR00738
324925002594	Transcriptional regulator; Region: Rrf2; pfam02082
324925002595	Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178
324925002596	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
324925002597	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
324925002598	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
324925002599	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
324925002600	oligomerisation interface [polypeptide binding]; other site
324925002601	mobile loop; other site
324925002602	roof hairpin; other site
324925002603	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
324925002604	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
324925002605	ring oligomerisation interface [polypeptide binding]; other site
324925002606	ATP/Mg binding site [chemical binding]; other site
324925002607	stacking interactions; other site
324925002608	hinge regions; other site
324925002609	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
324925002610	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
324925002611	Ligand Binding Site [chemical binding]; other site
324925002612	CAAX protease self-immunity; Region: Abi; cl00558
324925002613	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
324925002614	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
324925002615	substrate binding site [chemical binding]; other site
324925002616	active site
324925002617	catalytic residues [active]
324925002618	heterodimer interface [polypeptide binding]; other site
324925002619	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
324925002620	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
324925002621	Probable Catalytic site; other site
324925002622	metal-binding site
324925002623	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_11; cd08866
324925002624	putative hydrophobic ligand binding site [chemical binding]; other site
324925002625	cinnamyl-alcohol dehydrogenase family protein; Region: PLN02662
324925002626	aldehyde reductase, extended (e) SDRs; Region: AR_SDR_e; cd05227
324925002627	NADP binding site [chemical binding]; other site
324925002628	putative substrate binding site [chemical binding]; other site
324925002629	active site
324925002630	Cation efflux family; Region: Cation_efflux; pfam01545
324925002631	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
324925002632	Cation efflux family; Region: Cation_efflux; cl00316
324925002633	N-acetyl-alpha-D-glucosaminyl L-malate synthase BshA; Region: thiol_BshA; TIGR03999
324925002634	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_5; cd04962
324925002635	rod shape-determining protein MreB; Provisional; Region: PRK13930
324925002636	MreB and similar proteins; Region: MreB_like; cd10225
324925002637	nucleotide binding site [chemical binding]; other site
324925002638	Mg binding site [ion binding]; other site
324925002639	putative protofilament interaction site [polypeptide binding]; other site
324925002640	RodZ interaction site [polypeptide binding]; other site
324925002641	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
324925002642	histidinol dehydrogenase; Region: hisD; TIGR00069
324925002643	NAD binding site [chemical binding]; other site
324925002644	dimerization interface [polypeptide binding]; other site
324925002645	product binding site; other site
324925002646	substrate binding site [chemical binding]; other site
324925002647	zinc binding site [ion binding]; other site
324925002648	catalytic residues [active]
324925002649	Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547
324925002650	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
324925002651	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
324925002652	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
324925002653	substrate binding site [chemical binding]; other site
324925002654	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
324925002655	substrate binding site [chemical binding]; other site
324925002656	ligand binding site [chemical binding]; other site
324925002657	Membrane transport protein; Region: Mem_trans; cl09117
324925002658	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
324925002659	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
324925002660	hinge; other site
324925002661	active site
324925002662	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
324925002663	Peptidase family M23; Region: Peptidase_M23; pfam01551
324925002664	NAD synthetase; Provisional; Region: PRK13980
324925002665	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
324925002666	homodimer interface [polypeptide binding]; other site
324925002667	NAD binding pocket [chemical binding]; other site
324925002668	ATP binding pocket [chemical binding]; other site
324925002669	Mg binding site [ion binding]; other site
324925002670	active-site loop [active]
324925002671	L-aspartate oxidase; Provisional; Region: PRK09077
324925002672	L-aspartate oxidase; Provisional; Region: PRK06175
324925002673	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
324925002674	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
324925002675	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
324925002676	pyruvoyl-dependent arginine decarboxylase; Reviewed; Region: PRK01285
324925002677	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
324925002678	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
324925002679	active site
324925002680	HIGH motif; other site
324925002681	dimer interface [polypeptide binding]; other site
324925002682	KMSKS motif; other site
324925002683	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
324925002684	RNA binding surface [nucleotide binding]; other site
324925002685	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
324925002686	SmpB-tmRNA interface; other site
324925002687	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
324925002688	FAD binding domain; Region: FAD_binding_4; pfam01565
324925002689	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
324925002690	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
324925002691	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
324925002692	rod shape-determining protein MreC; Provisional; Region: PRK13922
324925002693	rod shape-determining protein MreC; Region: MreC; pfam04085
324925002694	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
324925002695	oligomerisation interface [polypeptide binding]; other site
324925002696	mobile loop; other site
324925002697	roof hairpin; other site
324925002698	quinolinate synthetase; Provisional; Region: PRK09375
324925002699	The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1...; Region: PB1; cl02720
324925002700	PB1 interaction [polypeptide binding]; other site
324925002701	PB1 interaction surface [polypeptide binding]; other site
324925002702	PB1 interaction surface [polypeptide binding]; other site
324925002703	PB1 interaction site [polypeptide binding]; other site
324925002704	PB1 interaction site [polypeptide binding]; other site
324925002705	PB1 interaction surface [polypeptide binding]; other site
324925002706	PB1 interaction surface [polypeptide binding]; other site
324925002707	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
324925002708	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
324925002709	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
324925002710	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204
324925002711	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
324925002712	dimer interface [polypeptide binding]; other site
324925002713	active site
324925002714	CoA binding pocket [chemical binding]; other site
324925002715	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
324925002716	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
324925002717	putative active site [active]
324925002718	heme pocket [chemical binding]; other site
324925002719	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
324925002720	dimer interface [polypeptide binding]; other site
324925002721	phosphorylation site [posttranslational modification]
324925002722	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
324925002723	ATP binding site [chemical binding]; other site
324925002724	Mg2+ binding site [ion binding]; other site
324925002725	G-X-G motif; other site
324925002726	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
324925002727	active site
324925002728	phosphorylation site [posttranslational modification]
324925002729	intermolecular recognition site; other site
324925002730	dimerization interface [polypeptide binding]; other site
324925002731	Phage Tail Collar Domain; Region: Collar; pfam07484
324925002732	Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737
324925002733	catalytic residues [active]
324925002734	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562
324925002735	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
324925002736	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
324925002737	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
324925002738	active site
324925002739	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
324925002740	TSCPD domain; Region: TSCPD; pfam12637
324925002741	radical SAM protein, TatD family-associated; Region: tatD_link_rSAM; TIGR04038
324925002742	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
324925002743	FeS/SAM binding site; other site
324925002744	Homospermidine synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG5310
324925002745	Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435
324925002746	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
324925002747	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
324925002748	dimer interface [polypeptide binding]; other site
324925002749	active site
324925002750	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
324925002751	catalytic residues [active]
324925002752	substrate binding site [chemical binding]; other site
324925002753	pyruvoyl-dependent arginine decarboxylase; Reviewed; Region: PRK01285
324925002754	Predicted DNA-binding proteins [General function prediction only]; Region: COG1342
324925002755	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
324925002756	Calcium binding; Region: Calci_bind_CcbP; pfam11535
324925002757	toxin interface [polypeptide binding]; other site
324925002758	YgiT-type zinc finger domain; Region: YgiT_finger; TIGR03831
324925002759	Zn binding site [ion binding]; other site
324925002760	Transposase [DNA replication, recombination, and repair]; Region: COG5421
324925002761	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
324925002762	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
324925002763	Divergent AAA domain; Region: AAA_4; pfam04326
324925002764	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
324925002765	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
324925002766	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4924
324925002767	Uncharacterized protein conserved in bacteria N-term (DUF3322); Region: DUF3322; pfam11795
324925002768	Uncharacterized protein conserved in bacteria C-term(DUF2220); Region: DUF2220; pfam09983
324925002769	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4913
324925002770	P-loop containing region of AAA domain; Region: AAA_29; pfam13555
324925002771	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
324925002772	P-loop containing region of AAA domain; Region: AAA_29; cl17516
324925002773	DNA topoisomerase I; Validated; Region: PRK07219
324925002774	Protein of unknown function (DUF3423); Region: DUF3423; pfam11903
324925002775	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
324925002776	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
324925002777	Domain of unknown function (DUF4194); Region: DUF4194; pfam13835
324925002778	Protein of unknown function (DUF3375); Region: DUF3375; pfam11855
324925002779	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
324925002780	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
324925002781	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1373
324925002782	AAA domain; Region: AAA_14; pfam13173
324925002783	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
324925002784	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
324925002785	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
324925002786	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
324925002787	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
324925002788	Walker A/P-loop; other site
324925002789	ATP binding site [chemical binding]; other site
324925002790	Q-loop/lid; other site
324925002791	ABC transporter signature motif; other site
324925002792	Walker B; other site
324925002793	D-loop; other site
324925002794	H-loop/switch region; other site
324925002795	4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557
324925002796	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
324925002797	Domain of unknown function (DUF4293); Region: DUF4293; pfam14126
324925002798	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
324925002799	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
324925002800	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
324925002801	4Fe-4S binding domain; Region: Fer4; cl02805
324925002802	thiosulfate reductase PhsA; Provisional; Region: PRK15488
324925002803	The MopB_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_Thiosulfate-R-like; cd02755
324925002804	putative [Fe4-S4] binding site [ion binding]; other site
324925002805	putative molybdopterin cofactor binding site [chemical binding]; other site
324925002806	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
324925002807	molybdopterin cofactor binding site; other site
324925002808	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
324925002809	Protein of unknown function (DUF497); Region: DUF497; pfam04365
324925002810	Protein of unknown function (DUF3680); Region: DUF3680; pfam12441
324925002811	DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525
324925002812	BRO family, N-terminal domain; Region: Bro-N; pfam02498
324925002813	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
324925002814	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
324925002815	active site
324925002816	motif I; other site
324925002817	motif II; other site
324925002818	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
324925002819	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274
324925002820	PhnA protein; Region: PhnA; pfam03831
324925002821	acylphosphatase; Provisional; Region: PRK14445
324925002822	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
324925002823	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
324925002824	dimer interface [polypeptide binding]; other site
324925002825	pyridoxal 5'-phosphate binding site [chemical binding]; other site
324925002826	catalytic residue [active]
324925002827	3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519
324925002828	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
324925002829	helicase 45; Provisional; Region: PTZ00424
324925002830	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
324925002831	ATP binding site [chemical binding]; other site
324925002832	Mg++ binding site [ion binding]; other site
324925002833	motif III; other site
324925002834	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
324925002835	nucleotide binding region [chemical binding]; other site
324925002836	ATP-binding site [chemical binding]; other site
324925002837	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
324925002838	putative RNA binding site [nucleotide binding]; other site
324925002839	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
324925002840	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
324925002841	Beta-Casp domain; Region: Beta-Casp; smart01027
324925002842	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
324925002843	Protein of unknown function (DUF2721); Region: DUF2721; pfam11026
324925002844	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
324925002845	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
324925002846	active site
324925002847	Int/Topo IB signature motif; other site
324925002848	16S rRNA methyltransferase B; Provisional; Region: PRK14904
324925002849	NusB family; Region: NusB; pfam01029
324925002850	putative RNA binding site [nucleotide binding]; other site
324925002851	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
324925002852	S-adenosylmethionine binding site [chemical binding]; other site
324925002853	OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326
324925002854	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
324925002855	homodimer interface [polypeptide binding]; other site
324925002856	substrate-cofactor binding pocket; other site
324925002857	pyridoxal 5'-phosphate binding site [chemical binding]; other site
324925002858	catalytic residue [active]
324925002859	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
324925002860	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
324925002861	seryl-tRNA synthetase; Provisional; Region: PRK05431
324925002862	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
324925002863	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
324925002864	dimer interface [polypeptide binding]; other site
324925002865	active site
324925002866	motif 1; other site
324925002867	motif 2; other site
324925002868	motif 3; other site
324925002869	Yqey-like protein; Region: YqeY; pfam09424
324925002870	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
324925002871	classical (c) SDRs; Region: SDR_c; cd05233
324925002872	NAD(P) binding site [chemical binding]; other site
324925002873	active site
324925002874	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
324925002875	DNA-binding site [nucleotide binding]; DNA binding site
324925002876	RNA-binding motif; other site
324925002877	hypothetical protein; Reviewed; Region: PRK00024
324925002878	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
324925002879	helix-hairpin-helix signature motif; other site
324925002880	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
324925002881	MPN+ (JAMM) motif; other site
324925002882	Zinc-binding site [ion binding]; other site
324925002883	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
324925002884	active site
324925002885	Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831
324925002886	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
324925002887	Surface antigen; Region: Bac_surface_Ag; pfam01103
324925002888	filamentous hemagglutinin family N-terminal domain; Region: adhes_NPXG; TIGR01901
324925002889	Cadherin repeat-like domain; Region: CA_like; cl15786
324925002890	serine acetyltransferase; Provisional; Region: cysE; PRK11132
324925002891	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
324925002892	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
324925002893	trimer interface [polypeptide binding]; other site
324925002894	active site
324925002895	substrate binding site [chemical binding]; other site
324925002896	CoA binding site [chemical binding]; other site
324925002897	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
324925002898	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
324925002899	Tetramer interface [polypeptide binding]; other site
324925002900	active site
324925002901	FMN-binding site [chemical binding]; other site
324925002902	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
324925002903	dimer interface [polypeptide binding]; other site
324925002904	allosteric magnesium binding site [ion binding]; other site
324925002905	active site
324925002906	aspartate-rich active site metal binding site; other site
324925002907	Schiff base residues; other site
324925002908	Na+-transporting oxaloacetate decarboxylase beta subunit; Region: OAD_beta; cl00816
324925002909	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
324925002910	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
324925002911	carboxyltransferase (CT) interaction site; other site
324925002912	biotinylation site [posttranslational modification]; other site
324925002913	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
324925002914	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
324925002915	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
324925002916	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
324925002917	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
324925002918	active site
324925002919	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
324925002920	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
324925002921	active site
324925002922	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
324925002923	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
324925002924	domain interfaces; other site
324925002925	active site
324925002926	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
324925002927	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
324925002928	tRNA; other site
324925002929	putative tRNA binding site [nucleotide binding]; other site
324925002930	putative NADP binding site [chemical binding]; other site
324925002931	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
324925002932	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
324925002933	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
324925002934	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
324925002935	G1 box; other site
324925002936	putative GEF interaction site [polypeptide binding]; other site
324925002937	GTP/Mg2+ binding site [chemical binding]; other site
324925002938	Switch I region; other site
324925002939	G2 box; other site
324925002940	G3 box; other site
324925002941	Switch II region; other site
324925002942	G4 box; other site
324925002943	G5 box; other site
324925002944	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
324925002945	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
324925002946	Rubredoxin [Energy production and conversion]; Region: COG1773
324925002947	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
324925002948	iron binding site [ion binding]; other site
324925002949	Rubredoxin; Region: Rubredoxin; pfam00301
324925002950	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
324925002951	iron binding site [ion binding]; other site
324925002952	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
324925002953	active site
324925002954	FMN binding site [chemical binding]; other site
324925002955	substrate binding site [chemical binding]; other site
324925002956	3Fe-4S cluster binding site [ion binding]; other site
324925002957	Rubrerythrin [Energy production and conversion]; Region: COG1592
324925002958	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
324925002959	binuclear metal center [ion binding]; other site
324925002960	Rubredoxin_like; nonheme iron binding domain containing a [Fe(SCys)4] center. The family includes rubredoxins, a small electron transfer protein, and a slightly smaller modular rubredoxin domain present in rubrerythrin and nigerythrin and detected either...; Region: rubredoxin_like; cl00202
324925002961	iron binding site [ion binding]; other site
324925002962	Predicted transcriptional regulator [Transcription]; Region: COG2378
324925002963	WYL domain; Region: WYL; pfam13280
324925002964	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
324925002965	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
324925002966	xanthine dehydrogenase; Region: PLN02906
324925002967	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
324925002968	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
324925002969	putative active site [active]
324925002970	putative NTP binding site [chemical binding]; other site
324925002971	putative nucleic acid binding site [nucleotide binding]; other site
324925002972	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
324925002973	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
324925002974	Transposase; Region: DDE_Tnp_ISL3; pfam01610
324925002975	HEAT repeats; Region: HEAT_2; pfam13646
324925002976	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
324925002977	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
324925002978	Virulence protein [General function prediction only]; Region: COG3943
324925002979	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
324925002980	mobile mystery protein B; Region: mob_myst_B; TIGR02613
324925002981	Fic/DOC family; Region: Fic; pfam02661
324925002982	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
324925002983	DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525
324925002984	BRO family, N-terminal domain; Region: Bro-N; pfam02498
324925002985	Predicted transcriptional regulator [Transcription]; Region: COG2944
324925002986	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
324925002987	non-specific DNA binding site [nucleotide binding]; other site
324925002988	salt bridge; other site
324925002989	sequence-specific DNA binding site [nucleotide binding]; other site
324925002990	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
324925002991	chlorophyllide reductase iron protein subunit X; Region: BchX; TIGR02016
324925002992	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
324925002993	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
324925002994	DNA binding residues [nucleotide binding]
324925002995	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202
324925002996	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
324925002997	putative NAD(P) binding site [chemical binding]; other site
324925002998	2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284
324925002999	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
324925003000	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
324925003001	C1 Peptidase family (MEROPS database nomenclature), also referred to as the papain family; composed of two subfamilies of cysteine peptidases (CPs), C1A (papain) and C1B (bleomycin hydrolase). Papain-like enzymes are mostly endopeptidases with some...; Region: Peptidase_C1; cd02619
324925003002	active site
324925003003	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
324925003004	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
324925003005	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
324925003006	active site
324925003007	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
324925003008	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
324925003009	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
324925003010	non-specific DNA binding site [nucleotide binding]; other site
324925003011	salt bridge; other site
324925003012	sequence-specific DNA binding site [nucleotide binding]; other site
324925003013	DinB family; Region: DinB; cl17821
324925003014	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
324925003015	AAA domain; Region: AAA_30; pfam13604
324925003016	Family description; Region: UvrD_C_2; pfam13538
324925003017	PUCC protein; Region: PUCC; pfam03209
324925003018	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
324925003019	FeS/SAM binding site; other site
324925003020	Radical SAM superfamily; Region: Radical_SAM; pfam04055
324925003021	Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168
324925003022	heme-binding residues [chemical binding]; other site
324925003023	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
324925003024	dimerization interface [polypeptide binding]; other site
324925003025	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
324925003026	dimer interface [polypeptide binding]; other site
324925003027	phosphorylation site [posttranslational modification]
324925003028	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
324925003029	ATP binding site [chemical binding]; other site
324925003030	Mg2+ binding site [ion binding]; other site
324925003031	G-X-G motif; other site
324925003032	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
324925003033	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
324925003034	active site
324925003035	phosphorylation site [posttranslational modification]
324925003036	intermolecular recognition site; other site
324925003037	dimerization interface [polypeptide binding]; other site
324925003038	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
324925003039	DNA binding site [nucleotide binding]
324925003040	polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709
324925003041	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
324925003042	Sel1-like repeats; Region: SEL1; smart00671
324925003043	Sel1-like repeats; Region: SEL1; smart00671
324925003044	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
324925003045	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
324925003046	substrate binding site [chemical binding]; other site
324925003047	glutamase interaction surface [polypeptide binding]; other site
324925003048	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
324925003049	Acyltransferase family; Region: Acyl_transf_3; pfam01757
324925003050	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
324925003051	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
324925003052	putative ADP-binding pocket [chemical binding]; other site
324925003053	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
324925003054	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
324925003055	Radical SAM superfamily; Region: Radical_SAM; pfam04055
324925003056	FeS/SAM binding site; other site
324925003057	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
324925003058	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
324925003059	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
324925003060	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
324925003061	trimer interface [polypeptide binding]; other site
324925003062	active site
324925003063	substrate binding site [chemical binding]; other site
324925003064	CoA binding site [chemical binding]; other site
324925003065	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
324925003066	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
324925003067	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
324925003068	AAA domain; Region: AAA_31; pfam13614
324925003069	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
324925003070	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
324925003071	A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194
324925003072	Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501
324925003073	Ligand binding site; other site
324925003074	metal-binding site
324925003075	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
324925003076	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
324925003077	polysaccharide export protein Wza; Provisional; Region: PRK15078
324925003078	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
324925003079	SLBB domain; Region: SLBB; pfam10531
324925003080	colanic acid biosynthesis acetyltransferase WcaB; Region: WcaB; TIGR04016
324925003081	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
324925003082	trimer interface [polypeptide binding]; other site
324925003083	active site
324925003084	substrate binding site [chemical binding]; other site
324925003085	CoA binding site [chemical binding]; other site
324925003086	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
324925003087	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
324925003088	active site
324925003089	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
324925003090	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
324925003091	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
324925003092	ATP binding site [chemical binding]; other site
324925003093	Mg2+ binding site [ion binding]; other site
324925003094	G-X-G motif; other site
324925003095	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
324925003096	anti sigma factor interaction site; other site
324925003097	regulatory phosphorylation site [posttranslational modification]; other site
324925003098	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
324925003099	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
324925003100	putative trimer interface [polypeptide binding]; other site
324925003101	putative CoA binding site [chemical binding]; other site
324925003102	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
324925003103	anti sigma factor interaction site; other site
324925003104	regulatory phosphorylation site [posttranslational modification]; other site
324925003105	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
324925003106	Bacterial sugar transferase; Region: Bac_transf; pfam02397
324925003107	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
324925003108	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
324925003109	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
324925003110	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
324925003111	Walker A motif; other site
324925003112	ATP binding site [chemical binding]; other site
324925003113	Walker B motif; other site
324925003114	Response regulator receiver domain; Region: Response_reg; pfam00072
324925003115	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
324925003116	active site
324925003117	phosphorylation site [posttranslational modification]
324925003118	intermolecular recognition site; other site
324925003119	dimerization interface [polypeptide binding]; other site
324925003120	PAS domain S-box; Region: sensory_box; TIGR00229
324925003121	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
324925003122	putative active site [active]
324925003123	heme pocket [chemical binding]; other site
324925003124	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
324925003125	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
324925003126	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
324925003127	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
324925003128	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
324925003129	UbiA prenyltransferase family; Region: UbiA; pfam01040
324925003130	N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573
324925003131	N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381
324925003132	putative active site; other site
324925003133	catalytic triad [active]
324925003134	putative dimer interface [polypeptide binding]; other site
324925003135	Peptidase family M48; Region: Peptidase_M48; pfam01435
324925003136	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
324925003137	Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371
324925003138	malate dehydrogenase; Reviewed; Region: PRK06223
324925003139	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
324925003140	NAD(P) binding site [chemical binding]; other site
324925003141	dimer interface [polypeptide binding]; other site
324925003142	tetramer (dimer of dimers) interface [polypeptide binding]; other site
324925003143	substrate binding site [chemical binding]; other site
324925003144	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
324925003145	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
324925003146	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
324925003147	MutS domain I; Region: MutS_I; pfam01624
324925003148	MutS domain II; Region: MutS_II; pfam05188
324925003149	MutS domain III; Region: MutS_III; pfam05192
324925003150	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
324925003151	Walker A/P-loop; other site
324925003152	ATP binding site [chemical binding]; other site
324925003153	Q-loop/lid; other site
324925003154	ABC transporter signature motif; other site
324925003155	Walker B; other site
324925003156	D-loop; other site
324925003157	H-loop/switch region; other site
324925003158	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
324925003159	B12 binding site [chemical binding]; other site
324925003160	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
324925003161	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
324925003162	FeS/SAM binding site; other site
324925003163	Protein of unknown function (DUF2281); Region: DUF2281; pfam10047
324925003164	YgiT-type zinc finger domain; Region: YgiT_finger; TIGR03831
324925003165	Zn binding site [ion binding]; other site
324925003166	toxin interface [polypeptide binding]; other site
324925003167	TIR domain; Region: TIR_2; pfam13676
324925003168	Uncharacterized conserved protein [Function unknown]; Region: COG1262
324925003169	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
324925003170	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
324925003171	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
324925003172	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
324925003173	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
324925003174	?-D-glucose-1-phosphatase; Provisional; Region: PRK09456
324925003175	hypothetical protein; Provisional; Region: PRK09256
324925003176	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
324925003177	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
324925003178	Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170
324925003179	dimer interface [polypeptide binding]; other site
324925003180	active site
324925003181	metal binding site [ion binding]; metal-binding site
324925003182	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
324925003183	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
324925003184	putative active site [active]
324925003185	putative metal binding site [ion binding]; other site
324925003186	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
324925003187	NACHT domain; Region: NACHT; pfam05729
324925003188	AAA domain; Region: AAA_14; pfam13173
324925003189	Uncharacterized conserved protein [Function unknown]; Region: COG1262
324925003190	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
324925003191	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
324925003192	oligomeric interface; other site
324925003193	putative active site [active]
324925003194	homodimer interface [polypeptide binding]; other site
324925003195	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
324925003196	Domain of unknown function (DUF4158); Region: DUF4158; pfam13700
324925003197	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
324925003198	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
324925003199	catalytic residues [active]
324925003200	catalytic nucleophile [active]
324925003201	Presynaptic Site I dimer interface [polypeptide binding]; other site
324925003202	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
324925003203	Synaptic Flat tetramer interface [polypeptide binding]; other site
324925003204	Synaptic Site I dimer interface [polypeptide binding]; other site
324925003205	DNA binding site [nucleotide binding]
324925003206	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
324925003207	DNA-binding interface [nucleotide binding]; DNA binding site
324925003208	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
324925003209	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
324925003210	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
324925003211	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
324925003212	Walker A/P-loop; other site
324925003213	ATP binding site [chemical binding]; other site
324925003214	Q-loop/lid; other site
324925003215	ABC transporter signature motif; other site
324925003216	Walker B; other site
324925003217	D-loop; other site
324925003218	H-loop/switch region; other site
324925003219	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
324925003220	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
324925003221	DNA binding residues [nucleotide binding]
324925003222	Bacteriochlorophyll A protein; Region: BChl_A; pfam02327
324925003223	apolipoprotein N-acyltransferase; Region: lnt; TIGR00546
324925003224	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
324925003225	putative active site [active]
324925003226	catalytic triad [active]
324925003227	putative dimer interface [polypeptide binding]; other site
324925003228	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
324925003229	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
324925003230	Walker A motif; other site
324925003231	ATP binding site [chemical binding]; other site
324925003232	Walker B motif; other site
324925003233	arginine finger; other site
324925003234	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
324925003235	Herpes DNA replication accessory factor; Region: Herpes_DNAp_acc; pfam04929
324925003236	Sporulation related domain; Region: SPOR; pfam05036
324925003237	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14616
324925003238	H-NS histone family; Region: Histone_HNS; pfam00816
324925003239	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
324925003240	Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_8; cd07586
324925003241	Predicted amidohydrolase [General function prediction only]; Region: COG0388
324925003242	putative active site [active]
324925003243	catalytic triad [active]
324925003244	putative dimer interface [polypeptide binding]; other site
324925003245	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
324925003246	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
324925003247	phosphopeptide binding site; other site
324925003248	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
324925003249	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
324925003250	phosphopeptide binding site; other site
324925003251	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
324925003252	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
324925003253	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
324925003254	phosphopeptide binding site; other site
324925003255	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
324925003256	active site
324925003257	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
324925003258	Winged helix-turn helix; Region: HTH_29; pfam13551
324925003259	Winged helix-turn helix; Region: HTH_33; pfam13592
324925003260	DDE superfamily endonuclease; Region: DDE_3; pfam13358
324925003261	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062
324925003262	Protein of unknown function (DUF805); Region: DUF805; pfam05656
324925003263	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
324925003264	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
324925003265	putative active site [active]
324925003266	putative NTP binding site [chemical binding]; other site
324925003267	putative nucleic acid binding site [nucleotide binding]; other site
324925003268	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
324925003269	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
324925003270	Catalytic domain of Protein Kinases; Region: PKc; cd00180
324925003271	active site
324925003272	ATP binding site [chemical binding]; other site
324925003273	substrate binding site [chemical binding]; other site
324925003274	activation loop (A-loop); other site
324925003275	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
324925003276	Catalytic domain of Protein Kinases; Region: PKc; cd00180
324925003277	active site
324925003278	ATP binding site [chemical binding]; other site
324925003279	substrate binding site [chemical binding]; other site
324925003280	activation loop (A-loop); other site
324925003281	Uncharacterized conserved protein [Function unknown]; Region: COG1262
324925003282	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
324925003283	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
324925003284	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
324925003285	dimer interface [polypeptide binding]; other site
324925003286	decamer (pentamer of dimers) interface [polypeptide binding]; other site
324925003287	catalytic triad [active]
324925003288	peroxidatic and resolving cysteines [active]
324925003289	prolyl-tRNA synthetase; Provisional; Region: PRK08661
324925003290	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778
324925003291	dimer interface [polypeptide binding]; other site
324925003292	motif 1; other site
324925003293	active site
324925003294	motif 2; other site
324925003295	motif 3; other site
324925003296	ProRS Prolyl-anticodon binding domain, long version found predominantly in eukaryotes and archaea. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in...; Region: ProRS_anticodon_zinc; cd00862
324925003297	anticodon binding site; other site
324925003298	zinc-binding site [ion binding]; other site
324925003299	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
324925003300	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
324925003301	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
324925003302	S-adenosylmethionine binding site [chemical binding]; other site
324925003303	heat shock gene repressor HrcA; Region: hrcA; TIGR00331
324925003304	GrpE; Region: GrpE; pfam01025
324925003305	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
324925003306	dimer interface [polypeptide binding]; other site
324925003307	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
324925003308	chaperone protein DnaJ; Provisional; Region: PRK14281
324925003309	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
324925003310	HSP70 interaction site [polypeptide binding]; other site
324925003311	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
324925003312	substrate binding site [polypeptide binding]; other site
324925003313	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
324925003314	Zn binding sites [ion binding]; other site
324925003315	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
324925003316	dimer interface [polypeptide binding]; other site
324925003317	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
324925003318	Malic enzyme, N-terminal domain; Region: malic; pfam00390
324925003319	Malic enzyme, NAD binding domain; Region: Malic_M; smart00919
324925003320	NAD(P) binding pocket [chemical binding]; other site
324925003321	Flavodoxin domain; Region: Flavodoxin_5; cl17428
324925003322	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
324925003323	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
324925003324	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
324925003325	UDP-N-acetylmuramate-alanine ligase [Cell envelope biogenesis, outer membrane]; Region: MurC; COG0773
324925003326	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
324925003327	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
324925003328	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
324925003329	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
324925003330	inhibitor-cofactor binding pocket; inhibition site
324925003331	pyridoxal 5'-phosphate binding site [chemical binding]; other site
324925003332	catalytic residue [active]
324925003333	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
324925003334	Major Facilitator Superfamily; Region: MFS_1; pfam07690
324925003335	putative substrate translocation pore; other site
324925003336	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
324925003337	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
324925003338	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
324925003339	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
324925003340	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
324925003341	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
324925003342	Walker A/P-loop; other site
324925003343	ATP binding site [chemical binding]; other site
324925003344	Q-loop/lid; other site
324925003345	ABC transporter signature motif; other site
324925003346	Walker B; other site
324925003347	D-loop; other site
324925003348	H-loop/switch region; other site
324925003349	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
324925003350	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
324925003351	putative catalytic cysteine [active]
324925003352	gamma-glutamyl kinase; Provisional; Region: PRK05429
324925003353	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
324925003354	nucleotide binding site [chemical binding]; other site
324925003355	homotetrameric interface [polypeptide binding]; other site
324925003356	putative phosphate binding site [ion binding]; other site
324925003357	putative allosteric binding site; other site
324925003358	PUA domain; Region: PUA; pfam01472
324925003359	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
324925003360	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
324925003361	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
324925003362	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
324925003363	Ligand Binding Site [chemical binding]; other site
324925003364	Transposase IS200 like; Region: Y1_Tnp; cl00848
324925003365	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
324925003366	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
324925003367	SelR domain; Region: SelR; pfam01641
324925003368	Curli production assembly/transport component CsgG; Region: CsgG; pfam03783
324925003369	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
324925003370	active site
324925003371	8-oxo-dGMP binding site [chemical binding]; other site
324925003372	nudix motif; other site
324925003373	metal binding site [ion binding]; metal-binding site
324925003374	von Willebrand factor type A domain; Region: VWA_2; pfam13519
324925003375	metal ion-dependent adhesion site (MIDAS); other site
324925003376	GTPase RsgA; Reviewed; Region: PRK01889
324925003377	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
324925003378	RNA binding site [nucleotide binding]; other site
324925003379	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
324925003380	GTPase/Zn-binding domain interface [polypeptide binding]; other site
324925003381	GTP/Mg2+ binding site [chemical binding]; other site
324925003382	G4 box; other site
324925003383	G5 box; other site
324925003384	G1 box; other site
324925003385	Switch I region; other site
324925003386	G2 box; other site
324925003387	G3 box; other site
324925003388	Switch II region; other site
324925003389	Beta-lactamase class D [Defense mechanisms]; Region: COG2602
324925003390	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
324925003391	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
324925003392	UbiA prenyltransferase family; Region: UbiA; pfam01040
324925003393	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
324925003394	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
324925003395	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
324925003396	DNA binding site [nucleotide binding]
324925003397	active site
324925003398	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
324925003399	Helix-turn-helix domain; Region: HTH_18; pfam12833
324925003400	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
324925003401	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
324925003402	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
324925003403	E3 interaction surface; other site
324925003404	lipoyl attachment site [posttranslational modification]; other site
324925003405	HlyD family secretion protein; Region: HlyD_3; pfam13437
324925003406	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
324925003407	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
324925003408	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
324925003409	FAD binding pocket [chemical binding]; other site
324925003410	FAD binding motif [chemical binding]; other site
324925003411	phosphate binding motif [ion binding]; other site
324925003412	beta-alpha-beta structure motif; other site
324925003413	NAD binding pocket [chemical binding]; other site
324925003414	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925003415	binding surface
324925003416	Tetratricopeptide repeat; Region: TPR_16; pfam13432
324925003417	TPR motif; other site
324925003418	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925003419	TPR motif; other site
324925003420	binding surface
324925003421	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
324925003422	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
324925003423	ATP binding site [chemical binding]; other site
324925003424	putative Mg++ binding site [ion binding]; other site
324925003425	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
324925003426	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
324925003427	nucleotide binding region [chemical binding]; other site
324925003428	ATP-binding site [chemical binding]; other site
324925003429	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
324925003430	Divergent AAA domain; Region: AAA_4; pfam04326
324925003431	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
324925003432	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
324925003433	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
324925003434	P-loop; other site
324925003435	Magnesium ion binding site [ion binding]; other site
324925003436	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
324925003437	Magnesium ion binding site [ion binding]; other site
324925003438	N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_c; cd10311
324925003439	putative active site [active]
324925003440	catalytic site [active]
324925003441	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
324925003442	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
324925003443	ATP binding site [chemical binding]; other site
324925003444	putative Mg++ binding site [ion binding]; other site
324925003445	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
324925003446	nucleotide binding region [chemical binding]; other site
324925003447	ATP-binding site [chemical binding]; other site
324925003448	Domain of unknown function (DUF4391); Region: DUF4391; pfam14335
324925003449	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
324925003450	DNA methylase; Region: N6_N4_Mtase; pfam01555
324925003451	DNA methylase; Region: N6_N4_Mtase; cl17433
324925003452	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
324925003453	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
324925003454	Restriction endonuclease [Defense mechanisms]; Region: COG3587
324925003455	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
324925003456	ATP binding site [chemical binding]; other site
324925003457	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
324925003458	TIGR02646 family protein; Region: TIGR02646
324925003459	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
324925003460	AAA domain; Region: AAA_21; pfam13304
324925003461	Walker A/P-loop; other site
324925003462	ATP binding site [chemical binding]; other site
324925003463	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
324925003464	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
324925003465	catalytic residues [active]
324925003466	bifunctional methionine sulfoxide reductase B/A protein; Provisional; Region: PRK05550
324925003467	Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841
324925003468	methionine sulfoxide reductase A; Provisional; Region: PRK14054
324925003469	peroxiredoxin; Provisional; Region: PRK13189
324925003470	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
324925003471	dimer interface [polypeptide binding]; other site
324925003472	decamer (pentamer of dimers) interface [polypeptide binding]; other site
324925003473	catalytic triad [active]
324925003474	Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641
324925003475	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
324925003476	active site
324925003477	bacteriochlorophyll/chlorophyll a synthase; Reviewed; Region: PRK07566
324925003478	UbiA prenyltransferase family; Region: UbiA; pfam01040
324925003479	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
324925003480	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
324925003481	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
324925003482	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
324925003483	hypothetical protein; Provisional; Region: PRK13795
324925003484	benzoyl-CoA oxygenase/reductase, BoxA protein; Region: benzo_boxA; TIGR03224
324925003485	PhoH-like protein; Region: PhoH; pfam02562
324925003486	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
324925003487	ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197
324925003488	NADP binding site [chemical binding]; other site
324925003489	homopentamer interface [polypeptide binding]; other site
324925003490	substrate binding site [chemical binding]; other site
324925003491	active site
324925003492	PAS fold; Region: PAS_4; pfam08448
324925003493	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
324925003494	putative active site [active]
324925003495	heme pocket [chemical binding]; other site
324925003496	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
324925003497	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
324925003498	putative active site [active]
324925003499	heme pocket [chemical binding]; other site
324925003500	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
324925003501	putative active site [active]
324925003502	heme pocket [chemical binding]; other site
324925003503	GAF domain; Region: GAF_2; pfam13185
324925003504	GAF domain; Region: GAF; pfam01590
324925003505	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
324925003506	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
324925003507	dimer interface [polypeptide binding]; other site
324925003508	phosphorylation site [posttranslational modification]
324925003509	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
324925003510	ATP binding site [chemical binding]; other site
324925003511	Mg2+ binding site [ion binding]; other site
324925003512	G-X-G motif; other site
324925003513	Response regulator receiver domain; Region: Response_reg; pfam00072
324925003514	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
324925003515	active site
324925003516	phosphorylation site [posttranslational modification]
324925003517	intermolecular recognition site; other site
324925003518	dimerization interface [polypeptide binding]; other site
324925003519	RNA polymerase sigma-70 factor, TIGR02947 family; Region: SigH_actino
324925003520	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
324925003521	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
324925003522	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
324925003523	pyridoxal 5'-phosphate binding site [chemical binding]; other site
324925003524	homodimer interface [polypeptide binding]; other site
324925003525	catalytic residue [active]
324925003526	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
324925003527	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
324925003528	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
324925003529	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
324925003530	putative active site [active]
324925003531	catalytic residue [active]
324925003532	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
324925003533	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
324925003534	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
324925003535	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
324925003536	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
324925003537	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
324925003538	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
324925003539	NADH(P)-binding; Region: NAD_binding_10; pfam13460
324925003540	NAD(P) binding site [chemical binding]; other site
324925003541	putative active site [active]
324925003542	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
324925003543	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
324925003544	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
324925003545	Ligand Binding Site [chemical binding]; other site
324925003546	membrane ATPase/protein kinase; Provisional; Region: PRK09435
324925003547	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
324925003548	Walker A; other site
324925003549	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
324925003550	G4 box; other site
324925003551	G5 box; other site
324925003552	The Death Domain Superfamily of protein-protein interaction domains; Region: DD_superfamily; cl14633
324925003553	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
324925003554	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
324925003555	active site
324925003556	substrate binding site [chemical binding]; other site
324925003557	coenzyme B12 binding site [chemical binding]; other site
324925003558	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
324925003559	B12 binding site [chemical binding]; other site
324925003560	cobalt ligand [ion binding]; other site
324925003561	methylmalonyl-CoA mutase, heterodimeric type, beta chain; Region: mmCoA_mut_beta; TIGR00642
324925003562	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Beta subunit-like subfamily; contains bacterial proteins similar to the beta subunit of MCMs from Propionbacterium shermanni and Streptomyces cinnamonensis, which are alpha/beta...; Region: MM_CoA_mutase_beta; cd03677
324925003563	heterodimer interface [polypeptide binding]; other site
324925003564	substrate interaction site [chemical binding]; other site
324925003565	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
324925003566	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
324925003567	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
324925003568	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
324925003569	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
324925003570	dimer interface [polypeptide binding]; other site
324925003571	substrate binding site [chemical binding]; other site
324925003572	metal binding site [ion binding]; metal-binding site
324925003573	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
324925003574	Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967
324925003575	acyl-activating enzyme (AAE) consensus motif; other site
324925003576	putative AMP binding site [chemical binding]; other site
324925003577	putative active site [active]
324925003578	putative CoA binding site [chemical binding]; other site
324925003579	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
324925003580	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
324925003581	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
324925003582	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
324925003583	PYR/PP interface [polypeptide binding]; other site
324925003584	dimer interface [polypeptide binding]; other site
324925003585	TPP binding site [chemical binding]; other site
324925003586	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
324925003587	hypothetical protein; Provisional; Region: PRK14621
324925003588	recombination protein RecR; Reviewed; Region: recR; PRK00076
324925003589	RecR protein; Region: RecR; pfam02132
324925003590	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
324925003591	putative active site [active]
324925003592	putative metal-binding site [ion binding]; other site
324925003593	tetramer interface [polypeptide binding]; other site
324925003594	phytoene desaturase; Region: phytoene_desat; TIGR02731
324925003595	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
324925003596	GAF domain; Region: GAF_2; pfam13185
324925003597	GAF domain; Region: GAF; pfam01590
324925003598	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
324925003599	phosphorylation site [posttranslational modification]
324925003600	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
324925003601	ATP binding site [chemical binding]; other site
324925003602	Mg2+ binding site [ion binding]; other site
324925003603	G-X-G motif; other site
324925003604	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
324925003605	Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655
324925003606	Predicted transcriptional regulator [Transcription]; Region: COG3905
324925003607	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
324925003608	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
324925003609	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
324925003610	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
324925003611	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
324925003612	uncharacterized bacterial subfamily of the Escherichia coli CorA-Salmonella typhimurium ZntB family; Region: EcCorA_ZntB-like_u2; cd12827
324925003613	Cl binding site [ion binding]; other site
324925003614	oligomer interface [polypeptide binding]; other site
324925003615	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
324925003616	putative catalytic site [active]
324925003617	putative metal binding site [ion binding]; other site
324925003618	putative phosphate binding site [ion binding]; other site
324925003619	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
324925003620	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
324925003621	ATP binding site [chemical binding]; other site
324925003622	active site
324925003623	substrate binding site [chemical binding]; other site
324925003624	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
324925003625	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
324925003626	transketolase; Reviewed; Region: PRK05899
324925003627	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
324925003628	TPP-binding site [chemical binding]; other site
324925003629	dimer interface [polypeptide binding]; other site
324925003630	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
324925003631	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
324925003632	S-adenosylmethionine binding site [chemical binding]; other site
324925003633	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
324925003634	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
324925003635	active site
324925003636	(T/H)XGH motif; other site
324925003637	aspartate aminotransferase; Provisional; Region: PRK05764
324925003638	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
324925003639	pyridoxal 5'-phosphate binding site [chemical binding]; other site
324925003640	homodimer interface [polypeptide binding]; other site
324925003641	catalytic residue [active]
324925003642	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
324925003643	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551
324925003644	putative acyl-acceptor binding pocket; other site
324925003645	PSP1 C-terminal conserved region; Region: PSP1; pfam04468
324925003646	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
324925003647	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
324925003648	active site
324925003649	HIGH motif; other site
324925003650	KMSKS motif; other site
324925003651	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
324925003652	tRNA binding surface [nucleotide binding]; other site
324925003653	anticodon binding site; other site
324925003654	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
324925003655	dimer interface [polypeptide binding]; other site
324925003656	putative tRNA-binding site [nucleotide binding]; other site
324925003657	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
324925003658	cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705
324925003659	FtsJ-like methyltransferase; Region: FtsJ; cl17430
324925003660	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
324925003661	S-adenosylmethionine binding site [chemical binding]; other site
324925003662	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
324925003663	anti sigma factor interaction site; other site
324925003664	regulatory phosphorylation site [posttranslational modification]; other site
324925003665	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
324925003666	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
324925003667	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
324925003668	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
324925003669	putative active site [active]
324925003670	heme pocket [chemical binding]; other site
324925003671	GAF domain; Region: GAF_2; pfam13185
324925003672	GAF domain; Region: GAF; pfam01590
324925003673	PAS domain S-box; Region: sensory_box; TIGR00229
324925003674	PAS domain; Region: PAS; smart00091
324925003675	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
324925003676	GAF domain; Region: GAF; cl17456
324925003677	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
324925003678	dimer interface [polypeptide binding]; other site
324925003679	phosphorylation site [posttranslational modification]
324925003680	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
324925003681	ATP binding site [chemical binding]; other site
324925003682	Mg2+ binding site [ion binding]; other site
324925003683	G-X-G motif; other site
324925003684	Response regulator receiver domain; Region: Response_reg; pfam00072
324925003685	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
324925003686	active site
324925003687	phosphorylation site [posttranslational modification]
324925003688	intermolecular recognition site; other site
324925003689	dimerization interface [polypeptide binding]; other site
324925003690	Membrane protein of unknown function; Region: DUF360; pfam04020
324925003691	DNA repair protein RadA; Provisional; Region: PRK11823
324925003692	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
324925003693	Walker A motif/ATP binding site; other site
324925003694	ATP binding site [chemical binding]; other site
324925003695	Walker B motif; other site
324925003696	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
324925003697	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14174
324925003698	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
324925003699	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
324925003700	homodimer interface [polypeptide binding]; other site
324925003701	NADP binding site [chemical binding]; other site
324925003702	substrate binding site [chemical binding]; other site
324925003703	Protein of unknown function (DUF3109); Region: DUF3109; pfam11307
324925003704	RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395
324925003705	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
324925003706	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
324925003707	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
324925003708	active site
324925003709	HslU subunit interaction site [polypeptide binding]; other site
324925003710	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
324925003711	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
324925003712	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
324925003713	Walker A motif; other site
324925003714	ATP binding site [chemical binding]; other site
324925003715	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
324925003716	Walker B motif; other site
324925003717	arginine finger; other site
324925003718	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
324925003719	Dehydroquinase class II; Region: DHquinase_II; pfam01220
324925003720	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
324925003721	trimer interface [polypeptide binding]; other site
324925003722	active site
324925003723	dimer interface [polypeptide binding]; other site
324925003724	adenylosuccinate lyase; Provisional; Region: PRK07492
324925003725	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
324925003726	tetramer interface [polypeptide binding]; other site
324925003727	active site
324925003728	Adenylosuccinate lyase C-terminus; Region: ADSL_C; smart00998
324925003729	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
324925003730	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
324925003731	active site
324925003732	NTP binding site [chemical binding]; other site
324925003733	metal binding triad [ion binding]; metal-binding site
324925003734	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
324925003735	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
324925003736	Zn2+ binding site [ion binding]; other site
324925003737	Mg2+ binding site [ion binding]; other site
324925003738	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
324925003739	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
324925003740	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
324925003741	Major Facilitator Superfamily; Region: MFS_1; pfam07690
324925003742	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
324925003743	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
324925003744	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
324925003745	cobalamin binding residues [chemical binding]; other site
324925003746	putative BtuC binding residues; other site
324925003747	dimer interface [polypeptide binding]; other site
324925003748	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
324925003749	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
324925003750	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
324925003751	ATP binding site [chemical binding]; other site
324925003752	putative Mg++ binding site [ion binding]; other site
324925003753	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
324925003754	Methyltransferase domain; Region: Methyltransf_26; pfam13659
324925003755	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
324925003756	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
324925003757	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
324925003758	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
324925003759	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
324925003760	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
324925003761	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
324925003762	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
324925003763	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
324925003764	TIR domain; Region: TIR_2; pfam13676
324925003765	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
324925003766	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
324925003767	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
324925003768	TIR domain; Region: TIR_2; pfam13676
324925003769	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
324925003770	HicB family; Region: HicB; pfam05534
324925003771	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
324925003772	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
324925003773	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
324925003774	nudix motif; other site
324925003775	TPR repeat; Region: TPR_11; pfam13414
324925003776	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925003777	binding surface
324925003778	TPR motif; other site
324925003779	TPR repeat; Region: TPR_11; pfam13414
324925003780	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925003781	binding surface
324925003782	TPR motif; other site
324925003783	TPR repeat; Region: TPR_11; pfam13414
324925003784	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820
324925003785	putative hydrophobic ligand binding site [chemical binding]; other site
324925003786	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
324925003787	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
324925003788	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
324925003789	PhoU domain; Region: PhoU; pfam01895
324925003790	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
324925003791	nucleotide binding site [chemical binding]; other site
324925003792	putative NEF/HSP70 interaction site [polypeptide binding]; other site
324925003793	SBD interface [polypeptide binding]; other site
324925003794	Ycf46; Provisional; Region: ycf46; CHL00195
324925003795	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
324925003796	Walker A motif; other site
324925003797	ATP binding site [chemical binding]; other site
324925003798	Walker B motif; other site
324925003799	arginine finger; other site
324925003800	Uncharacterized conserved protein [Function unknown]; Region: COG1262
324925003801	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
324925003802	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
324925003803	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925003804	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925003805	TPR motif; other site
324925003806	binding surface
324925003807	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925003808	Virulence protein [General function prediction only]; Region: COG3943
324925003809	Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310
324925003810	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
324925003811	Transposase; Region: DDE_Tnp_ISL3; pfam01610
324925003812	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
324925003813	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
324925003814	putative active site [active]
324925003815	putative NTP binding site [chemical binding]; other site
324925003816	putative nucleic acid binding site [nucleotide binding]; other site
324925003817	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
324925003818	Fic/DOC family; Region: Fic; pfam02661
324925003819	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
324925003820	MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245
324925003821	substrate binding site [chemical binding]; other site
324925003822	TIR domain; Region: TIR_2; pfam13676
324925003823	FOG: WD40 repeat [General function prediction only]; Region: COG2319
324925003824	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200
324925003825	structural tetrad; other site
324925003826	PQQ-like domain; Region: PQQ_2; pfam13360
324925003827	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
324925003828	structural tetrad; other site
324925003829	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
324925003830	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
324925003831	Repair protein; Region: Repair_PSII; pfam04536
324925003832	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
324925003833	Repair protein; Region: Repair_PSII; pfam04536
324925003834	Putative methyltransferase; Region: Methyltransf_4; cl17290
324925003835	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
324925003836	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
324925003837	N-terminal plug; other site
324925003838	ligand-binding site [chemical binding]; other site
324925003839	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
324925003840	putative FMN binding site [chemical binding]; other site
324925003841	cobyric acid synthase; Provisional; Region: PRK00784
324925003842	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
324925003843	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
324925003844	catalytic triad [active]
324925003845	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
324925003846	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
324925003847	pyridoxal 5'-phosphate binding site [chemical binding]; other site
324925003848	homodimer interface [polypeptide binding]; other site
324925003849	catalytic residue [active]
324925003850	cobalamin biosynthesis protein; Provisional; Region: cobD; PRK01209
324925003851	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; pfam02572
324925003852	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
324925003853	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
324925003854	ABC-ATPase subunit  interface; other site
324925003855	dimer interface [polypeptide binding]; other site
324925003856	putative PBP binding regions; other site
324925003857	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
324925003858	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
324925003859	Walker A/P-loop; other site
324925003860	ATP binding site [chemical binding]; other site
324925003861	Q-loop/lid; other site
324925003862	ABC transporter signature motif; other site
324925003863	Walker B; other site
324925003864	D-loop; other site
324925003865	H-loop/switch region; other site
324925003866	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
324925003867	Predicted DNA-binding protein with an HTH domain [General function prediction only]; Region: COG4710
324925003868	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
324925003869	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183
324925003870	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
324925003871	putative active site [active]
324925003872	metal binding site [ion binding]; metal-binding site
324925003873	SET domain; Region: SET; pfam00856
324925003874	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
324925003875	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
324925003876	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
324925003877	putative active site [active]
324925003878	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359
324925003879	putative dimer interface [polypeptide binding]; other site
324925003880	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
324925003881	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
324925003882	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
324925003883	Walker A/P-loop; other site
324925003884	ATP binding site [chemical binding]; other site
324925003885	Q-loop/lid; other site
324925003886	ABC transporter signature motif; other site
324925003887	Walker B; other site
324925003888	D-loop; other site
324925003889	H-loop/switch region; other site
324925003890	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
324925003891	FtsX-like permease family; Region: FtsX; pfam02687
324925003892	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
324925003893	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
324925003894	FtsX-like permease family; Region: FtsX; pfam02687
324925003895	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
324925003896	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
324925003897	HlyD family secretion protein; Region: HlyD_3; pfam13437
324925003898	flavoprotein, HI0933 family; Region: TIGR00275
324925003899	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
324925003900	Domain of unknown function (DUF4402); Region: DUF4402; pfam14352
324925003901	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
324925003902	Domain of unknown function (DUF4402); Region: DUF4402; pfam14352
324925003903	P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121
324925003904	Domain of unknown function (DUF4402); Region: DUF4402; pfam14352
324925003905	Domain of unknown function (DUF4372); Region: DUF4372; pfam14294
324925003906	Transposase IS200 like; Region: Y1_Tnp; pfam01797
324925003907	Domain of unknown function (DUF4402); Region: DUF4402; pfam14352
324925003908	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
324925003909	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
324925003910	homotrimer interface [polypeptide binding]; other site
324925003911	Walker A motif; other site
324925003912	GTP binding site [chemical binding]; other site
324925003913	Walker B motif; other site
324925003914	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
324925003915	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
324925003916	putative dimer interface [polypeptide binding]; other site
324925003917	active site pocket [active]
324925003918	putative cataytic base [active]
324925003919	cobalamin synthase; Reviewed; Region: cobS; PRK00235
324925003920	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
324925003921	bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625
324925003922	active site
324925003923	metal binding site [ion binding]; metal-binding site
324925003924	Uncharacterized protein conserved in bacteria (DUF2141); Region: DUF2141; pfam09912
324925003925	PAS domain; Region: PAS; smart00091
324925003926	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
324925003927	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
324925003928	dimer interface [polypeptide binding]; other site
324925003929	phosphorylation site [posttranslational modification]
324925003930	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
324925003931	ATP binding site [chemical binding]; other site
324925003932	Mg2+ binding site [ion binding]; other site
324925003933	G-X-G motif; other site
324925003934	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925003935	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925003936	binding surface
324925003937	TPR motif; other site
324925003938	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925003939	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925003940	binding surface
324925003941	TPR motif; other site
324925003942	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925003943	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925003944	binding surface
324925003945	TPR motif; other site
324925003946	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925003947	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925003948	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925003949	binding surface
324925003950	TPR motif; other site
324925003951	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925003952	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925003953	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925003954	binding surface
324925003955	TPR motif; other site
324925003956	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925003957	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925003958	binding surface
324925003959	TPR motif; other site
324925003960	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925003961	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925003962	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925003963	Tetratricopeptide repeat; Region: TPR_10; pfam13374
324925003964	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
324925003965	FAD binding domain; Region: FAD_binding_4; pfam01565
324925003966	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
324925003967	Domon-like domain of UDP-N-acetylenolpyruvoylglucosamine reductase; Region: DOMON_murB_like; cd09627
324925003968	putative heme binding site [chemical binding]; other site
324925003969	cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345
324925003970	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
324925003971	FAD binding pocket [chemical binding]; other site
324925003972	FAD binding motif [chemical binding]; other site
324925003973	phosphate binding motif [ion binding]; other site
324925003974	beta-alpha-beta structure motif; other site
324925003975	NAD binding pocket [chemical binding]; other site
324925003976	Iron coordination center [ion binding]; other site
324925003977	anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055
324925003978	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
324925003979	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
324925003980	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
324925003981	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
324925003982	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
324925003983	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
324925003984	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
324925003985	Cysteine-rich domain; Region: CCG; pfam02754
324925003986	Cysteine-rich domain; Region: CCG; pfam02754
324925003987	aspartate aminotransferase; Provisional; Region: PRK08636
324925003988	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
324925003989	pyridoxal 5'-phosphate binding site [chemical binding]; other site
324925003990	homodimer interface [polypeptide binding]; other site
324925003991	catalytic residue [active]
324925003992	YjeF-related protein N-terminus; Region: YjeF_N; pfam03853
324925003993	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
324925003994	putative substrate binding site [chemical binding]; other site
324925003995	putative ATP binding site [chemical binding]; other site
324925003996	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
324925003997	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
324925003998	dimerization interface [polypeptide binding]; other site
324925003999	ATP binding site [chemical binding]; other site
324925004000	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
324925004001	dimerization interface [polypeptide binding]; other site
324925004002	ATP binding site [chemical binding]; other site
324925004003	preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12900
324925004004	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
324925004005	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
324925004006	nucleotide binding region [chemical binding]; other site
324925004007	ATP-binding site [chemical binding]; other site
324925004008	SEC-C motif; Region: SEC-C; pfam02810
324925004009	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
324925004010	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
324925004011	NAD(P) binding site [chemical binding]; other site
324925004012	putative active site [active]
324925004013	8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934
324925004014	8-oxoguanine DNA-glycosylase (ogg); Region: ogg; TIGR00588
324925004015	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
324925004016	minor groove reading motif; other site
324925004017	helix-hairpin-helix signature motif; other site
324925004018	substrate binding pocket [chemical binding]; other site
324925004019	active site
324925004020	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
324925004021	NADH(P)-binding; Region: NAD_binding_10; pfam13460
324925004022	NAD(P) binding site [chemical binding]; other site
324925004023	putative active site [active]
324925004024	lipoyl synthase; Provisional; Region: PRK05481
324925004025	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
324925004026	FeS/SAM binding site; other site
324925004027	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
324925004028	IHF - DNA interface [nucleotide binding]; other site
324925004029	IHF dimer interface [polypeptide binding]; other site
324925004030	PAS fold; Region: PAS_4; pfam08448
324925004031	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
324925004032	dimer interface [polypeptide binding]; other site
324925004033	phosphorylation site [posttranslational modification]
324925004034	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
324925004035	ATP binding site [chemical binding]; other site
324925004036	Mg2+ binding site [ion binding]; other site
324925004037	G-X-G motif; other site
324925004038	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
324925004039	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
324925004040	active site
324925004041	phosphorylation site [posttranslational modification]
324925004042	intermolecular recognition site; other site
324925004043	dimerization interface [polypeptide binding]; other site
324925004044	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
324925004045	Walker A motif; other site
324925004046	ATP binding site [chemical binding]; other site
324925004047	Walker B motif; other site
324925004048	arginine finger; other site
324925004049	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
324925004050	Cytochrome c; Region: Cytochrom_C; cl11414
324925004051	Domain of unknown function (DUF4405); Region: DUF4405; pfam14358
324925004052	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
324925004053	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
324925004054	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
324925004055	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
324925004056	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
324925004057	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
324925004058	HlyD family secretion protein; Region: HlyD_3; pfam13437
324925004059	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
324925004060	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
324925004061	FtsX-like permease family; Region: FtsX; pfam02687
324925004062	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
324925004063	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
324925004064	Walker A/P-loop; other site
324925004065	ATP binding site [chemical binding]; other site
324925004066	Q-loop/lid; other site
324925004067	ABC transporter signature motif; other site
324925004068	Walker B; other site
324925004069	D-loop; other site
324925004070	H-loop/switch region; other site
324925004071	bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604
324925004072	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
324925004073	trimer interface [polypeptide binding]; other site
324925004074	dimer interface [polypeptide binding]; other site
324925004075	putative active site [active]
324925004076	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
324925004077	MPT binding site; other site
324925004078	trimer interface [polypeptide binding]; other site
324925004079	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
324925004080	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
324925004081	dimer interface [polypeptide binding]; other site
324925004082	putative functional site; other site
324925004083	putative MPT binding site; other site
324925004084	putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MobA; Provisional; Region: PRK14490
324925004085	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
324925004086	Walker A motif; other site
324925004087	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
324925004088	GTP binding site; other site
324925004089	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
324925004090	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
324925004091	molybdopterin cofactor binding site; other site
324925004092	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
324925004093	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
324925004094	The MopB_CT_Thiosulfate-R-like CD contains thiosulfate-, sulfur-, and polysulfide-reductases, and other related proteins. Thiosulfate reductase catalyzes the cleavage of sulfur-sulfur bonds in thiosulfate. Polysulfide reductase is a membrane-bound enzyme...; Region: MopB_CT_Thiosulfate-R-like; cd02778
324925004095	putative molybdopterin cofactor binding site; other site
324925004096	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
324925004097	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
324925004098	Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613
324925004099	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
324925004100	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
324925004101	FeS/SAM binding site; other site
324925004102	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
324925004103	MOSC domain; Region: MOSC; pfam03473
324925004104	OsmC-like protein; Region: OsmC; pfam02566
324925004105	Predicted DNA-binding proteins [General function prediction only]; Region: COG1342
324925004106	Ribosomal L32p protein family; Region: Ribosomal_L32p; cl09115
324925004107	Methyltransferase domain; Region: Methyltransf_31; pfam13847
324925004108	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
324925004109	S-adenosylmethionine binding site [chemical binding]; other site
324925004110	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; pfam09603
324925004111	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
324925004112	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
324925004113	Uncharacterized conserved protein [Function unknown]; Region: COG1434
324925004114	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
324925004115	putative active site [active]
324925004116	PAS domain S-box; Region: sensory_box; TIGR00229
324925004117	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
324925004118	putative active site [active]
324925004119	heme pocket [chemical binding]; other site
324925004120	GAF domain; Region: GAF_2; pfam13185
324925004121	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
324925004122	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
324925004123	dimer interface [polypeptide binding]; other site
324925004124	phosphorylation site [posttranslational modification]
324925004125	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
324925004126	ATP binding site [chemical binding]; other site
324925004127	Mg2+ binding site [ion binding]; other site
324925004128	G-X-G motif; other site
324925004129	Response regulator receiver domain; Region: Response_reg; pfam00072
324925004130	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
324925004131	active site
324925004132	phosphorylation site [posttranslational modification]
324925004133	intermolecular recognition site; other site
324925004134	dimerization interface [polypeptide binding]; other site
324925004135	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
324925004136	classical (c) SDRs; Region: SDR_c; cd05233
324925004137	NAD(P) binding site [chemical binding]; other site
324925004138	active site
324925004139	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
324925004140	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
324925004141	ligand binding site [chemical binding]; other site
324925004142	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
324925004143	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
324925004144	putative NADP binding site [chemical binding]; other site
324925004145	putative substrate binding site [chemical binding]; other site
324925004146	active site
324925004147	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
324925004148	S-adenosylmethionine binding site [chemical binding]; other site
324925004149	dihydroorotase; Validated; Region: pyrC; PRK09357
324925004150	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
324925004151	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
324925004152	active site
324925004153	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
324925004154	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
324925004155	polyphosphate kinase; Provisional; Region: PRK05443
324925004156	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
324925004157	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
324925004158	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
324925004159	putative domain interface [polypeptide binding]; other site
324925004160	putative active site [active]
324925004161	catalytic site [active]
324925004162	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
324925004163	putative domain interface [polypeptide binding]; other site
324925004164	putative active site [active]
324925004165	catalytic site [active]
324925004166	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
324925004167	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
324925004168	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
324925004169	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
324925004170	metal binding site [ion binding]; metal-binding site
324925004171	dimer interface [polypeptide binding]; other site
324925004172	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
324925004173	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
324925004174	intersubunit interface [polypeptide binding]; other site
324925004175	active site
324925004176	zinc binding site [ion binding]; other site
324925004177	Na+ binding site [ion binding]; other site
324925004178	carboxy-terminal protease; Provisional; Region: PRK11186
324925004179	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
324925004180	protein binding site [polypeptide binding]; other site
324925004181	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
324925004182	Catalytic dyad [active]
324925004183	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
324925004184	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
324925004185	S-adenosylmethionine binding site [chemical binding]; other site
324925004186	carboxy-terminal protease; Provisional; Region: PRK11186
324925004187	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
324925004188	protein binding site [polypeptide binding]; other site
324925004189	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
324925004190	Catalytic dyad [active]
324925004191	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
324925004192	argininosuccinate lyase; Provisional; Region: PRK00855
324925004193	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
324925004194	active sites [active]
324925004195	tetramer interface [polypeptide binding]; other site
324925004196	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
324925004197	Catalytic site [active]
324925004198	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
324925004199	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
324925004200	active site
324925004201	DNA binding site [nucleotide binding]
324925004202	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
324925004203	Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654
324925004204	putative addiction module antidote; Region: doc_partner; TIGR02609
324925004205	Dicarboxylate transport; Region: DctA-YdbH; cl14674
324925004206	Dicarboxylate transport; Region: DctA-YdbH; cl14674
324925004207	Dicarboxylate transport; Region: DctA-YdbH; pfam11739
324925004208	Protein of unknown function (DUF1318); Region: DUF1318; pfam07027
324925004209	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
324925004210	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
324925004211	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
324925004212	Fibrobacter succinogenes major domain (Fib_succ_major); Region: Fib_succ_major; cl09821
324925004213	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
324925004214	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
324925004215	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
324925004216	sequence-specific DNA binding site [nucleotide binding]; other site
324925004217	salt bridge; other site
324925004218	argininosuccinate synthase; Provisional; Region: PRK13820
324925004219	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
324925004220	ANP binding site [chemical binding]; other site
324925004221	Substrate Binding Site II [chemical binding]; other site
324925004222	Substrate Binding Site I [chemical binding]; other site
324925004223	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
324925004224	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
324925004225	ornithine carbamoyltransferase; Provisional; Region: PRK00779
324925004226	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
324925004227	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
324925004228	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
324925004229	feedback inhibition sensing region; other site
324925004230	homohexameric interface [polypeptide binding]; other site
324925004231	nucleotide binding site [chemical binding]; other site
324925004232	N-acetyl-L-glutamate binding site [chemical binding]; other site
324925004233	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
324925004234	heterotetramer interface [polypeptide binding]; other site
324925004235	active site pocket [active]
324925004236	cleavage site
324925004237	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
324925004238	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
324925004239	PBP superfamily domain; Region: PBP_like_2; pfam12849
324925004240	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
324925004241	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
324925004242	metal binding site [ion binding]; metal-binding site
324925004243	active site
324925004244	I-site; other site
324925004245	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
324925004246	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
324925004247	FtsX-like permease family; Region: FtsX; pfam02687
324925004248	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
324925004249	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
324925004250	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
324925004251	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
324925004252	Coenzyme A binding pocket [chemical binding]; other site
324925004253	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
324925004254	Rubredoxin; Region: Rubredoxin; pfam00301
324925004255	iron binding site [ion binding]; other site
324925004256	Predicted membrane protein [Function unknown]; Region: COG2119
324925004257	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
324925004258	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
324925004259	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
324925004260	Succinyl-CoA synthetase, beta subunit [Energy production and conversion]; Region: SucC; COG0045
324925004261	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
324925004262	CoA binding domain; Region: CoA_binding; smart00881
324925004263	ATP citrate (pro-S)-lyase; Region: PLN02522
324925004264	CoA-ligase; Region: Ligase_CoA; pfam00549
324925004265	Citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CCL cleaves citryl-CoA (CiCoA) to acetyl-CoA (AcCoA) and oxaloacetate (OAA); Region: CCL_ACL-C; cd06100
324925004266	active site
324925004267	oxalacetate binding site [chemical binding]; other site
324925004268	citrylCoA binding site [chemical binding]; other site
324925004269	coenzyme A binding site [chemical binding]; other site
324925004270	catalytic triad [active]
324925004271	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
324925004272	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
324925004273	Protein of unknown function DUF86; Region: DUF86; pfam01934
324925004274	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
324925004275	active site
324925004276	NTP binding site [chemical binding]; other site
324925004277	metal binding triad [ion binding]; metal-binding site
324925004278	antibiotic binding site [chemical binding]; other site
324925004279	Uncharacterized conserved protein [Function unknown]; Region: COG3472
324925004280	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
324925004281	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
324925004282	Predicted transcriptional regulator [Transcription]; Region: COG2944
324925004283	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
324925004284	putative active site [active]
324925004285	Protein of unknown function (DUF2281); Region: DUF2281; cl02355
324925004286	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
324925004287	Uncharacterized conserved protein [Function unknown]; Region: COG3472
324925004288	Transposase IS200 like; Region: Y1_Tnp; pfam01797
324925004289	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
324925004290	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
324925004291	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925004292	binding surface
324925004293	TPR motif; other site
324925004294	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925004295	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925004296	binding surface
324925004297	TPR motif; other site
324925004298	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925004299	type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987
324925004300	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
324925004301	DEAD-like helicases superfamily; Region: DEXDc; smart00487
324925004302	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
324925004303	ATP binding site [chemical binding]; other site
324925004304	putative Mg++ binding site [ion binding]; other site
324925004305	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
324925004306	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
324925004307	nucleotide binding region [chemical binding]; other site
324925004308	ATP-binding site [chemical binding]; other site
324925004309	Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205
324925004310	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
324925004311	ATP binding site [chemical binding]; other site
324925004312	putative Mg++ binding site [ion binding]; other site
324925004313	helicase superfamily c-terminal domain; Region: HELICc; smart00490
324925004314	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
324925004315	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
324925004316	AAA domain; Region: AAA_30; pfam13604
324925004317	Family description; Region: UvrD_C_2; pfam13538
324925004318	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
324925004319	IHF dimer interface [polypeptide binding]; other site
324925004320	IHF - DNA interface [nucleotide binding]; other site
324925004321	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
324925004322	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
324925004323	PAS domain; Region: PAS; smart00091
324925004324	putative active site [active]
324925004325	heme pocket [chemical binding]; other site
324925004326	GAF domain; Region: GAF_2; pfam13185
324925004327	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
324925004328	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
324925004329	phosphorylation site [posttranslational modification]
324925004330	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
324925004331	ATP binding site [chemical binding]; other site
324925004332	Mg2+ binding site [ion binding]; other site
324925004333	G-X-G motif; other site
324925004334	Divergent AAA domain; Region: AAA_4; pfam04326
324925004335	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
324925004336	Predicted transcriptional regulators [Transcription]; Region: COG1695
324925004337	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
324925004338	dimerization interface [polypeptide binding]; other site
324925004339	putative Zn2+ binding site [ion binding]; other site
324925004340	putative DNA binding site [nucleotide binding]; other site
324925004341	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
324925004342	putative DNA binding site [nucleotide binding]; other site
324925004343	putative Zn2+ binding site [ion binding]; other site
324925004344	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
324925004345	AAA domain; Region: AAA_30; pfam13604
324925004346	Family description; Region: UvrD_C_2; pfam13538
324925004347	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
324925004348	Family description; Region: UvrD_C_2; pfam13538
324925004349	Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257
324925004350	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
324925004351	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
324925004352	DNA protecting protein DprA; Region: dprA; TIGR00732
324925004353	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
324925004354	putative DNA binding site [nucleotide binding]; other site
324925004355	dimerization interface [polypeptide binding]; other site
324925004356	putative Zn2+ binding site [ion binding]; other site
324925004357	Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514
324925004358	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
324925004359	ATP binding site [chemical binding]; other site
324925004360	putative Mg++ binding site [ion binding]; other site
324925004361	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
324925004362	nucleotide binding region [chemical binding]; other site
324925004363	ATP-binding site [chemical binding]; other site
324925004364	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
324925004365	active site
324925004366	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
324925004367	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
324925004368	motif II; other site
324925004369	Predicted membrane protein [Function unknown]; Region: COG3304
324925004370	Domain of unknown function (DUF307); Region: DUF307; pfam03733
324925004371	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
324925004372	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
324925004373	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
324925004374	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
324925004375	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
324925004376	BRO family, N-terminal domain; Region: Bro-N; smart01040
324925004377	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
324925004378	Divergent AAA domain; Region: AAA_4; pfam04326
324925004379	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
324925004380	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
324925004381	TIR domain; Region: TIR_2; pfam13676
324925004382	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
324925004383	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
324925004384	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
324925004385	HsdM N-terminal domain; Region: HsdM_N; pfam12161
324925004386	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
324925004387	Methyltransferase domain; Region: Methyltransf_26; pfam13659
324925004388	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
324925004389	Divergent AAA domain; Region: AAA_4; pfam04326
324925004390	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
324925004391	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
324925004392	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
324925004393	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
324925004394	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
324925004395	ATP binding site [chemical binding]; other site
324925004396	putative Mg++ binding site [ion binding]; other site
324925004397	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
324925004398	substrate binding site [chemical binding]; other site
324925004399	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
324925004400	AAA domain; Region: AAA_27; pfam13514
324925004401	Walker A/P-loop; other site
324925004402	ATP binding site [chemical binding]; other site
324925004403	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
324925004404	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
324925004405	active site
324925004406	metal binding site [ion binding]; metal-binding site
324925004407	DNA binding site [nucleotide binding]
324925004408	6-phosphofructokinase; Provisional; Region: PRK03202
324925004409	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
324925004410	active site
324925004411	ADP/pyrophosphate binding site [chemical binding]; other site
324925004412	dimerization interface [polypeptide binding]; other site
324925004413	allosteric effector site; other site
324925004414	fructose-1,6-bisphosphate binding site; other site
324925004415	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
324925004416	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
324925004417	Walker A motif; other site
324925004418	ATP binding site [chemical binding]; other site
324925004419	Walker B motif; other site
324925004420	RyR domain; Region: RyR; pfam02026
324925004421	RyR domain; Region: RyR; pfam02026
324925004422	Protein of unknown function (DUF4231); Region: DUF4231; pfam14015
324925004423	DDE superfamily endonuclease; Region: DDE_3; pfam13358
324925004424	Winged helix-turn helix; Region: HTH_29; pfam13551
324925004425	Homeodomain-like domain; Region: HTH_23; cl17451
324925004426	Homeodomain-like domain; Region: HTH_32; pfam13565
324925004427	Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990
324925004428	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
324925004429	nucleophilic elbow; other site
324925004430	catalytic triad; other site
324925004431	Caspase domain; Region: Peptidase_C14; pfam00656
324925004432	TIR domain; Region: TIR_2; pfam13676
324925004433	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925004434	Tetratricopeptide repeat; Region: TPR_10; pfam13374
324925004435	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925004436	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925004437	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925004438	TPR motif; other site
324925004439	binding surface
324925004440	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925004441	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925004442	Tetratricopeptide repeat; Region: TPR_10; pfam13374
324925004443	Tetratricopeptide repeat; Region: TPR_10; pfam13374
324925004444	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925004445	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925004446	binding surface
324925004447	TPR motif; other site
324925004448	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925004449	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
324925004450	Low molecular weight phosphatase family; Region: LMWPc; cd00115
324925004451	active site
324925004452	Predicted permeases [General function prediction only]; Region: COG0701
324925004453	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
324925004454	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
324925004455	dimerization interface [polypeptide binding]; other site
324925004456	putative DNA binding site [nucleotide binding]; other site
324925004457	putative Zn2+ binding site [ion binding]; other site
324925004458	Cytochrome c; Region: Cytochrom_C; pfam00034
324925004459	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
324925004460	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
324925004461	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
324925004462	sequence-specific DNA binding site [nucleotide binding]; other site
324925004463	salt bridge; other site
324925004464	RmuC family; Region: RmuC; pfam02646
324925004465	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
324925004466	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
324925004467	inhibitor-cofactor binding pocket; inhibition site
324925004468	pyridoxal 5'-phosphate binding site [chemical binding]; other site
324925004469	catalytic residue [active]
324925004470	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
324925004471	Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465
324925004472	active site
324925004473	NAD binding site [chemical binding]; other site
324925004474	metal binding site [ion binding]; metal-binding site
324925004475	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
324925004476	ligand binding site; other site
324925004477	tetramer interface; other site
324925004478	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
324925004479	Uncharacterized protein family (UPF0104); Region: UPF0104; cl04219
324925004480	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
324925004481	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
324925004482	acyl-activating enzyme (AAE) consensus motif; other site
324925004483	putative AMP binding site [chemical binding]; other site
324925004484	putative active site [active]
324925004485	putative CoA binding site [chemical binding]; other site
324925004486	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
324925004487	endonuclease III; Region: ENDO3c; smart00478
324925004488	minor groove reading motif; other site
324925004489	helix-hairpin-helix signature motif; other site
324925004490	substrate binding pocket [chemical binding]; other site
324925004491	active site
324925004492	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
324925004493	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
324925004494	16S rRNA processing protein RimM; Region: 16S_RimM; TIGR02273
324925004495	RimM N-terminal domain; Region: RimM; pfam01782
324925004496	PRC-barrel domain; Region: PRC; pfam05239
324925004497	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
324925004498	signal recognition particle protein; Provisional; Region: PRK10867
324925004499	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
324925004500	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
324925004501	P loop; other site
324925004502	GTP binding site [chemical binding]; other site
324925004503	Signal peptide binding domain; Region: SRP_SPB; pfam02978
324925004504	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
324925004505	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
324925004506	putative ribose interaction site [chemical binding]; other site
324925004507	putative ADP binding site [chemical binding]; other site
324925004508	Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876
324925004509	putative lipid binding site [chemical binding]; other site
324925004510	Uncharacterized subgroup of the steroidogenic acute regulatory protein (StAR)-related lipid transfer (START) domain family; Region: START_1; cd08876
324925004511	putative lipid binding site [chemical binding]; other site
324925004512	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
324925004513	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
324925004514	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
324925004515	protein binding site [polypeptide binding]; other site
324925004516	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
324925004517	Catalytic dyad [active]
324925004518	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
324925004519	homotrimer interaction site [polypeptide binding]; other site
324925004520	putative active site [active]
324925004521	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
324925004522	thiamine phosphate binding site [chemical binding]; other site
324925004523	active site
324925004524	pyrophosphate binding site [ion binding]; other site
324925004525	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
324925004526	thiamine phosphate binding site [chemical binding]; other site
324925004527	active site
324925004528	pyrophosphate binding site [ion binding]; other site
324925004529	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
324925004530	dimer interface [polypeptide binding]; other site
324925004531	substrate binding site [chemical binding]; other site
324925004532	ATP binding site [chemical binding]; other site
324925004533	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
324925004534	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
324925004535	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
324925004536	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
324925004537	Biogenesis of lysosome-related organelles complex-1 subunit 2; Region: BLOC1_2; pfam10046
324925004538	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
324925004539	PGAP1-like protein; Region: PGAP1; pfam07819
324925004540	multifunctional aminopeptidase A; Provisional; Region: PRK00913
324925004541	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
324925004542	interface (dimer of trimers) [polypeptide binding]; other site
324925004543	Substrate-binding/catalytic site; other site
324925004544	Zn-binding sites [ion binding]; other site
324925004545	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
324925004546	DHH family; Region: DHH; pfam01368
324925004547	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14456
324925004548	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
324925004549	FeS/SAM binding site; other site
324925004550	adenylate kinase; Reviewed; Region: adk; PRK00279
324925004551	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
324925004552	AMP-binding site [chemical binding]; other site
324925004553	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
324925004554	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
324925004555	primosomal protein N' Region: priA; TIGR00595
324925004556	ATP binding site [chemical binding]; other site
324925004557	putative Mg++ binding site [ion binding]; other site
324925004558	helicase superfamily c-terminal domain; Region: HELICc; smart00490
324925004559	ATP-binding site [chemical binding]; other site
324925004560	putative voltage-gated ClC-type chloride channel ClcB; Provisional; Region: PRK01862
324925004561	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
324925004562	Cl- selectivity filter; other site
324925004563	Cl- binding residues [ion binding]; other site
324925004564	pore gating glutamate residue; other site
324925004565	dimer interface [polypeptide binding]; other site
324925004566	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with either the SpoIVFB domain (sporulation protein, stage IV cell wall formation, F locus, promoter-distal B) or the chloride channel protein EriC; Region: CBS_pair_SpoIVFB_EriC_assoc2; cd04613
324925004567	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
324925004568	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
324925004569	active site
324925004570	dimer interface [polypeptide binding]; other site
324925004571	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
324925004572	dimer interface [polypeptide binding]; other site
324925004573	active site
324925004574	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
324925004575	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
324925004576	ATP binding site [chemical binding]; other site
324925004577	Mg2+ binding site [ion binding]; other site
324925004578	G-X-G motif; other site
324925004579	Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901
324925004580	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
324925004581	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
324925004582	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
324925004583	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
324925004584	ligand binding site [chemical binding]; other site
324925004585	NAD binding site [chemical binding]; other site
324925004586	dimerization interface [polypeptide binding]; other site
324925004587	catalytic site [active]
324925004588	ACT_3PGDH-like CD includes the C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-like; cd04879
324925004589	L-serine binding site [chemical binding]; other site
324925004590	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
324925004591	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
324925004592	P loop; other site
324925004593	Nucleotide binding site [chemical binding]; other site
324925004594	DTAP/Switch II; other site
324925004595	Switch I; other site
324925004596	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
324925004597	N-acetyl-D-glucosamine binding site [chemical binding]; other site
324925004598	catalytic residue [active]
324925004599	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
324925004600	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
324925004601	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
324925004602	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
324925004603	dimerization interface 3.5A [polypeptide binding]; other site
324925004604	active site
324925004605	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
324925004606	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
324925004607	active site
324925004608	catalytic site [active]
324925004609	Ribokinase-like subgroup C.  Found only in bacteria, this subgroup is part of the ribokinase/pfkB superfamily.  Its oligomerization state is unknown at this time; Region: ribokinase_group_C; cd01946
324925004610	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
324925004611	substrate binding site [chemical binding]; other site
324925004612	ATP binding site [chemical binding]; other site
324925004613	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477
324925004614	Na binding site [ion binding]; other site
324925004615	Maf-like protein; Region: Maf; pfam02545
324925004616	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
324925004617	active site
324925004618	dimer interface [polypeptide binding]; other site
324925004619	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide A dehydrogenase; Region: bchC; TIGR01202
324925004620	2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255
324925004621	putative NAD(P) binding site [chemical binding]; other site
324925004622	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
324925004623	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
324925004624	Walker A/P-loop; other site
324925004625	ATP binding site [chemical binding]; other site
324925004626	Q-loop/lid; other site
324925004627	ABC transporter signature motif; other site
324925004628	Walker B; other site
324925004629	D-loop; other site
324925004630	H-loop/switch region; other site
324925004631	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
324925004632	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
324925004633	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
324925004634	TM-ABC transporter signature motif; other site
324925004635	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
324925004636	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
324925004637	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
324925004638	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
324925004639	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
324925004640	substrate binding pocket [chemical binding]; other site
324925004641	chain length determination region; other site
324925004642	substrate-Mg2+ binding site; other site
324925004643	catalytic residues [active]
324925004644	aspartate-rich region 1; other site
324925004645	active site lid residues [active]
324925004646	aspartate-rich region 2; other site
324925004647	Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902
324925004648	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819
324925004649	dephospho-CoA kinase; Provisional; Region: coaE; PRK14731
324925004650	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
324925004651	CoA-binding site [chemical binding]; other site
324925004652	ATP-binding [chemical binding]; other site
324925004653	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
324925004654	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
324925004655	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
324925004656	Domain of unknown function (DUF4292); Region: DUF4292; pfam14125
324925004657	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
324925004658	PUA domain; Region: PUA; cl00607
324925004659	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
324925004660	putative RNA binding site [nucleotide binding]; other site
324925004661	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
324925004662	S-adenosylmethionine binding site [chemical binding]; other site
324925004663	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
324925004664	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831
324925004665	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
324925004666	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
324925004667	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
324925004668	motif II; other site
324925004669	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
324925004670	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
324925004671	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
324925004672	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
324925004673	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
324925004674	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
324925004675	catalytic residues [active]
324925004676	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
324925004677	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
324925004678	catalytic residues [active]
324925004679	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
324925004680	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
324925004681	active site
324925004682	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
324925004683	generic binding surface II; other site
324925004684	generic binding surface I; other site
324925004685	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
324925004686	non-specific DNA binding site [nucleotide binding]; other site
324925004687	salt bridge; other site
324925004688	sequence-specific DNA binding site [nucleotide binding]; other site
324925004689	Domain of unknown function (DUF955); Region: DUF955; pfam06114
324925004690	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
324925004691	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
324925004692	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
324925004693	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
324925004694	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
324925004695	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
324925004696	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
324925004697	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
324925004698	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
324925004699	AAA ATPase domain; Region: AAA_16; pfam13191
324925004700	NACHT domain; Region: NACHT; pfam05729
324925004701	Uncharacterized conserved protein [Function unknown]; Region: COG1262
324925004702	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
324925004703	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875
324925004704	putative active site [active]
324925004705	Protein of unknown function (DUF2281); Region: DUF2281; pfam10047
324925004706	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
324925004707	HipA N-terminal domain; Region: Couple_hipA; cl11853
324925004708	HipA-like N-terminal domain; Region: HipA_N; pfam07805
324925004709	HipA-like C-terminal domain; Region: HipA_C; pfam07804
324925004710	Helix-turn-helix domain; Region: HTH_31; pfam13560
324925004711	sequence-specific DNA binding site [nucleotide binding]; other site
324925004712	salt bridge; other site
324925004713	NACHT domain; Region: NACHT; pfam05729
324925004714	AAA domain; Region: AAA_14; pfam13173
324925004715	Uncharacterized conserved protein [Function unknown]; Region: COG1262
324925004716	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
324925004717	Predicted AAA-ATPase; Region: AAA-ATPase_like; pfam09820
324925004718	Protein of unknown function (DUF1703); Region: DUF1703; pfam08011
324925004719	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
324925004720	NACHT domain; Region: NACHT; pfam05729
324925004721	Walker A/P-loop; other site
324925004722	ATP binding site [chemical binding]; other site
324925004723	Uncharacterized conserved protein [Function unknown]; Region: COG1262
324925004724	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
324925004725	Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016
324925004726	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
324925004727	active site
324925004728	catalytic residues [active]
324925004729	metal binding site [ion binding]; metal-binding site
324925004730	homodimer binding site [polypeptide binding]; other site
324925004731	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
324925004732	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06549
324925004733	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
324925004734	carboxyltransferase (CT) interaction site; other site
324925004735	biotinylation site [posttranslational modification]; other site
324925004736	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
324925004737	Fumarase C-terminus; Region: Fumerase_C; pfam05683
324925004738	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
324925004739	Ligand Binding Site [chemical binding]; other site
324925004740	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2187
324925004741	Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021
324925004742	AAA domain; Region: AAA_33; pfam13671
324925004743	ATP-binding site [chemical binding]; other site
324925004744	Gluconate-6-phosphate binding site [chemical binding]; other site
324925004745	Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044
324925004746	diiron binding motif [ion binding]; other site
324925004747	CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431
324925004748	heat shock protein 90; Provisional; Region: PRK05218
324925004749	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
324925004750	ATP binding site [chemical binding]; other site
324925004751	Mg2+ binding site [ion binding]; other site
324925004752	G-X-G motif; other site
324925004753	NeuB family; Region: NeuB; pfam03102
324925004754	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
324925004755	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
324925004756	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
324925004757	dimer interface [polypeptide binding]; other site
324925004758	substrate binding site [chemical binding]; other site
324925004759	metal binding sites [ion binding]; metal-binding site
324925004760	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
324925004761	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
324925004762	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
324925004763	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
324925004764	G1 box; other site
324925004765	putative GEF interaction site [polypeptide binding]; other site
324925004766	GTP/Mg2+ binding site [chemical binding]; other site
324925004767	Switch I region; other site
324925004768	G2 box; other site
324925004769	G3 box; other site
324925004770	Switch II region; other site
324925004771	G4 box; other site
324925004772	G5 box; other site
324925004773	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
324925004774	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
324925004775	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
324925004776	metal-binding site [ion binding]
324925004777	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
324925004778	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
324925004779	motif II; other site
324925004780	Domain of unknown function (DUF1848); Region: DUF1848; pfam08902
324925004781	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
324925004782	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
324925004783	metal binding site [ion binding]; metal-binding site
324925004784	dimer interface [polypeptide binding]; other site
324925004785	Domain of unknown function (DU1801); Region: DUF1801; pfam08818
324925004786	NACHT domain; Region: NACHT; pfam05729
324925004787	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
324925004788	Walker A/P-loop; other site
324925004789	ATP binding site [chemical binding]; other site
324925004790	Uncharacterized conserved protein [Function unknown]; Region: COG1262
324925004791	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
324925004792	Protein of unknown function DUF86; Region: DUF86; pfam01934
324925004793	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
324925004794	active site
324925004795	NTP binding site [chemical binding]; other site
324925004796	metal binding triad [ion binding]; metal-binding site
324925004797	antibiotic binding site [chemical binding]; other site
324925004798	This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142
324925004799	putative FMN binding site [chemical binding]; other site
324925004800	NADPH bind site [chemical binding]; other site
324925004801	Protein of unknown function DUF45; Region: DUF45; pfam01863
324925004802	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
324925004803	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
324925004804	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
324925004805	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
324925004806	sequence-specific DNA binding site [nucleotide binding]; other site
324925004807	salt bridge; other site
324925004808	Putative addiction module component; Region: Unstab_antitox; pfam09720
324925004809	Caspase domain; Region: Peptidase_C14; pfam00656
324925004810	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
324925004811	amino acid transporter; Region: 2A0306; TIGR00909
324925004812	C-terminus of AA_permease; Region: AA_permease_C; pfam13906
324925004813	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
324925004814	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
324925004815	NAD(P) binding site [chemical binding]; other site
324925004816	active site
324925004817	thymidylate kinase; Validated; Region: tmk; PRK00698
324925004818	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
324925004819	TMP-binding site; other site
324925004820	ATP-binding site [chemical binding]; other site
324925004821	sucrose-phosphate phosphatase subfamily; Region: SPP-subfamily; TIGR01482
324925004822	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
324925004823	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
324925004824	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
324925004825	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
324925004826	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
324925004827	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
324925004828	Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547
324925004829	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
324925004830	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
324925004831	substrate binding site; other site
324925004832	dimer interface; other site
324925004833	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
324925004834	CoenzymeA binding site [chemical binding]; other site
324925004835	subunit interaction site [polypeptide binding]; other site
324925004836	PHB binding site; other site
324925004837	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
324925004838	B12 binding site [chemical binding]; other site
324925004839	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
324925004840	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
324925004841	FeS/SAM binding site; other site
324925004842	Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905
324925004843	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
324925004844	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
324925004845	dimer interface [polypeptide binding]; other site
324925004846	anticodon binding site; other site
324925004847	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
324925004848	homodimer interface [polypeptide binding]; other site
324925004849	motif 1; other site
324925004850	active site
324925004851	motif 2; other site
324925004852	GAD domain; Region: GAD; pfam02938
324925004853	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
324925004854	active site
324925004855	motif 3; other site
324925004856	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14954
324925004857	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14955
324925004858	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
324925004859	Walker A motif; other site
324925004860	ATP binding site [chemical binding]; other site
324925004861	Walker B motif; other site
324925004862	arginine finger; other site
324925004863	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
324925004864	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
324925004865	Vacuole effluxer Atg22 like; Region: ATG22; pfam11700
324925004866	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
324925004867	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
324925004868	putative active site [active]
324925004869	catalytic triad [active]
324925004870	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
324925004871	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
324925004872	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
324925004873	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
324925004874	oligomerization interface [polypeptide binding]; other site
324925004875	active site
324925004876	metal binding site [ion binding]; metal-binding site
324925004877	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
324925004878	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
324925004879	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
324925004880	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
324925004881	D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478
324925004882	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
324925004883	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
324925004884	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
324925004885	HlyD family secretion protein; Region: HlyD_3; pfam13437
324925004886	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
324925004887	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
324925004888	Walker A/P-loop; other site
324925004889	ATP binding site [chemical binding]; other site
324925004890	Q-loop/lid; other site
324925004891	ABC transporter signature motif; other site
324925004892	Walker B; other site
324925004893	D-loop; other site
324925004894	H-loop/switch region; other site
324925004895	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
324925004896	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
324925004897	FtsX-like permease family; Region: FtsX; pfam02687
324925004898	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
324925004899	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
324925004900	FtsX-like permease family; Region: FtsX; pfam02687
324925004901	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
324925004902	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
324925004903	ligand binding site [chemical binding]; other site
324925004904	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
324925004905	Glucoamylase and related glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: SGA1; COG3387
324925004906	Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723
324925004907	Rrp15p; Region: Rrp15p; pfam07890
324925004908	Protein of unknown function, DUF547; Region: DUF547; pfam04784
324925004909	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
324925004910	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
324925004911	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
324925004912	trimer interface [polypeptide binding]; other site
324925004913	active site
324925004914	UDP-GlcNAc binding site [chemical binding]; other site
324925004915	lipid binding site [chemical binding]; lipid-binding site
324925004916	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
324925004917	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
324925004918	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
324925004919	active site
324925004920	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
324925004921	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
324925004922	5S rRNA interface [nucleotide binding]; other site
324925004923	CTC domain interface [polypeptide binding]; other site
324925004924	L16 interface [polypeptide binding]; other site
324925004925	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
324925004926	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
324925004927	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
324925004928	dimer interface [polypeptide binding]; other site
324925004929	conserved gate region; other site
324925004930	putative PBP binding loops; other site
324925004931	ABC-ATPase subunit interface; other site
324925004932	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
324925004933	Competence protein; Region: Competence; pfam03772
324925004934	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
324925004935	FAD binding site [chemical binding]; other site
324925004936	diaminopimelate decarboxylase; Region: lysA; TIGR01048
324925004937	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
324925004938	active site
324925004939	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
324925004940	substrate binding site [chemical binding]; other site
324925004941	catalytic residues [active]
324925004942	dimer interface [polypeptide binding]; other site
324925004943	Ribosomal protein L33; Region: Ribosomal_L33; cl00383
324925004944	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
324925004945	Putative zinc ribbon domain; Region: DUF164; pfam02591
324925004946	Protein of unknown function (DUF3683); Region: DUF3683; pfam12447
324925004947	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
324925004948	FAD binding domain; Region: FAD_binding_4; pfam01565
324925004949	FAD linked oxidases, C-terminal domain; Region: FAD-oxidase_C; pfam02913
324925004950	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
324925004951	Cysteine-rich domain; Region: CCG; pfam02754
324925004952	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
324925004953	CheB methylesterase; Region: CheB_methylest; pfam01339
324925004954	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
324925004955	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
324925004956	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
324925004957	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
324925004958	PAS domain; Region: PAS_10; pfam13596
324925004959	PAS domain S-box; Region: sensory_box; TIGR00229
324925004960	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
324925004961	putative active site [active]
324925004962	heme pocket [chemical binding]; other site
324925004963	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
324925004964	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
324925004965	putative active site [active]
324925004966	heme pocket [chemical binding]; other site
324925004967	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
324925004968	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
324925004969	putative active site [active]
324925004970	heme pocket [chemical binding]; other site
324925004971	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
324925004972	putative active site [active]
324925004973	heme pocket [chemical binding]; other site
324925004974	PAS fold; Region: PAS_3; pfam08447
324925004975	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
324925004976	dimer interface [polypeptide binding]; other site
324925004977	phosphorylation site [posttranslational modification]
324925004978	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
324925004979	ATP binding site [chemical binding]; other site
324925004980	Mg2+ binding site [ion binding]; other site
324925004981	G-X-G motif; other site
324925004982	Response regulator receiver domain; Region: Response_reg; pfam00072
324925004983	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
324925004984	active site
324925004985	phosphorylation site [posttranslational modification]
324925004986	intermolecular recognition site; other site
324925004987	dimerization interface [polypeptide binding]; other site
324925004988	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
324925004989	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
324925004990	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
324925004991	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
324925004992	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752
324925004993	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757
324925004994	Family of unknown function (DUF694); Region: DUF694; pfam05107
324925004995	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cd09637
324925004996	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721
324925004997	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
324925004998	Domain of unknown function (DUF4403); Region: DUF4403; pfam14356
324925004999	Transposase domain (DUF772); Region: DUF772; pfam05598
324925005000	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
324925005001	DDE superfamily endonuclease; Region: DDE_4; cl17710
324925005002	Transposase [DNA replication, recombination, and repair]; Region: COG5421
324925005003	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
324925005004	PAS fold; Region: PAS_3; pfam08447
324925005005	putative active site [active]
324925005006	heme pocket [chemical binding]; other site
324925005007	PAS fold; Region: PAS_3; pfam08447
324925005008	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
324925005009	putative active site [active]
324925005010	heme pocket [chemical binding]; other site
324925005011	PAS domain S-box; Region: sensory_box; TIGR00229
324925005012	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
324925005013	putative active site [active]
324925005014	heme pocket [chemical binding]; other site
324925005015	PAS domain S-box; Region: sensory_box; TIGR00229
324925005016	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
324925005017	putative active site [active]
324925005018	heme pocket [chemical binding]; other site
324925005019	PAS domain; Region: PAS_9; pfam13426
324925005020	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
324925005021	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
324925005022	dimer interface [polypeptide binding]; other site
324925005023	phosphorylation site [posttranslational modification]
324925005024	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
324925005025	ATP binding site [chemical binding]; other site
324925005026	Mg2+ binding site [ion binding]; other site
324925005027	G-X-G motif; other site
324925005028	Response regulator receiver domain; Region: Response_reg; pfam00072
324925005029	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
324925005030	active site
324925005031	phosphorylation site [posttranslational modification]
324925005032	intermolecular recognition site; other site
324925005033	dimerization interface [polypeptide binding]; other site
324925005034	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
324925005035	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
324925005036	NAD(P) binding site [chemical binding]; other site
324925005037	active site
324925005038	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
324925005039	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
324925005040	active site
324925005041	catalytic site [active]
324925005042	substrate binding site [chemical binding]; other site
324925005043	Domain of unknown function (DUF3127); Region: DUF3127; pfam11325
324925005044	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
324925005045	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
324925005046	active site
324925005047	DoxX-like family; Region: DoxX_3; pfam13781
324925005048	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
324925005049	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
324925005050	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
324925005051	HlyD family secretion protein; Region: HlyD_3; pfam13437
324925005052	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
324925005053	PhoU domain; Region: PhoU; pfam01895
324925005054	PhoU domain; Region: PhoU; pfam01895
324925005055	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
324925005056	PhoU domain; Region: PhoU; pfam01895
324925005057	PhoU domain; Region: PhoU; pfam01895
324925005058	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14275
324925005059	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
324925005060	Walker A/P-loop; other site
324925005061	ATP binding site [chemical binding]; other site
324925005062	Q-loop/lid; other site
324925005063	ABC transporter signature motif; other site
324925005064	Walker B; other site
324925005065	D-loop; other site
324925005066	H-loop/switch region; other site
324925005067	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
324925005068	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
324925005069	dimer interface [polypeptide binding]; other site
324925005070	conserved gate region; other site
324925005071	putative PBP binding loops; other site
324925005072	ABC-ATPase subunit interface; other site
324925005073	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
324925005074	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
324925005075	conserved gate region; other site
324925005076	putative PBP binding loops; other site
324925005077	ABC-ATPase subunit interface; other site
324925005078	PBP superfamily domain; Region: PBP_like_2; cl17296
324925005079	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
324925005080	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
324925005081	motif II; other site
324925005082	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
324925005083	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
324925005084	active site
324925005085	metal binding site [ion binding]; metal-binding site
324925005086	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
324925005087	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
324925005088	Synechococcus sp. strain PCC 7942  PhoA and related proteins, N-terminal metallophosphatase domain; Region: MPP_PhoA_N; cd08162
324925005089	putative active site [active]
324925005090	putative metal binding site [ion binding]; other site
324925005091	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
324925005092	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
324925005093	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
324925005094	dimer interface [polypeptide binding]; other site
324925005095	active site
324925005096	Dystroglycan-type cadherin-like domains; Region: CADG; smart00736
324925005097	Bacterial Ig-like domain; Region: Big_5; pfam13205
324925005098	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
324925005099	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
324925005100	Coenzyme A binding pocket [chemical binding]; other site
324925005101	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
324925005102	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
324925005103	putative acyl-acceptor binding pocket; other site
324925005104	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
324925005105	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
324925005106	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
324925005107	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
324925005108	putative active site [active]
324925005109	putative metal binding site [ion binding]; other site
324925005110	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
324925005111	non-specific DNA binding site [nucleotide binding]; other site
324925005112	salt bridge; other site
324925005113	sequence-specific DNA binding site [nucleotide binding]; other site
324925005114	E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387
324925005115	pyruvoyl-dependent arginine decarboxylase; Reviewed; Region: PRK01285
324925005116	E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370
324925005117	E3 ubiquitin-protein ligase SspH2; Provisional; Region: PRK15387
324925005118	Protein of unknown function (DUF2934); Region: DUF2934; pfam11154
324925005119	CHAD domain; Region: CHAD; pfam05235
324925005120	CHAD domain; Region: CHAD; pfam05235
324925005121	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
324925005122	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
324925005123	P-loop; other site
324925005124	Magnesium ion binding site [ion binding]; other site
324925005125	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
324925005126	Magnesium ion binding site [ion binding]; other site
324925005127	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
324925005128	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
324925005129	dimer interface [polypeptide binding]; other site
324925005130	active site
324925005131	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
324925005132	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
324925005133	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
324925005134	active site
324925005135	phosphorylation site [posttranslational modification]
324925005136	intermolecular recognition site; other site
324925005137	dimerization interface [polypeptide binding]; other site
324925005138	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
324925005139	DNA binding site [nucleotide binding]
324925005140	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
324925005141	dimerization interface [polypeptide binding]; other site
324925005142	PAS domain; Region: PAS; smart00091
324925005143	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
324925005144	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
324925005145	dimer interface [polypeptide binding]; other site
324925005146	phosphorylation site [posttranslational modification]
324925005147	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
324925005148	ATP binding site [chemical binding]; other site
324925005149	Mg2+ binding site [ion binding]; other site
324925005150	G-X-G motif; other site
324925005151	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
324925005152	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
324925005153	active site
324925005154	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
324925005155	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
324925005156	DXD motif; other site
324925005157	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
324925005158	Putative addiction module component; Region: Unstab_antitox; pfam09720
324925005159	Uncharacterized protein family (UPF0093); Region: UPF0093; cl00863
324925005160	Uncharacterized conserved protein [Function unknown]; Region: COG2442
324925005161	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634
324925005162	Photosystem II Pbs27; Region: PSII_Pbs27; cl11841
324925005163	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925005164	binding surface
324925005165	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925005166	TPR motif; other site
324925005167	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925005168	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925005169	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925005170	binding surface
324925005171	TPR motif; other site
324925005172	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925005173	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925005174	binding surface
324925005175	TPR motif; other site
324925005176	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925005177	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925005178	Protein of unknown function (DUF497); Region: DUF497; pfam04365
324925005179	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
324925005180	Protein of unknown function (DUF1778); Region: DUF1778; pfam08681
324925005181	PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872
324925005182	putative active site [active]
324925005183	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
324925005184	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
324925005185	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
324925005186	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
324925005187	non-specific DNA binding site [nucleotide binding]; other site
324925005188	salt bridge; other site
324925005189	sequence-specific DNA binding site [nucleotide binding]; other site
324925005190	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
324925005191	ABC transporter signature motif; other site
324925005192	Walker B; other site
324925005193	D-loop; other site
324925005194	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
324925005195	putative active site [active]
324925005196	putative metal binding site [ion binding]; other site
324925005197	tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081
324925005198	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
324925005199	SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105
324925005200	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
324925005201	Domain of unknown function (DUF4332); Region: DUF4332; pfam14229
324925005202	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
324925005203	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
324925005204	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
324925005205	HflX GTPase family; Region: HflX; cd01878
324925005206	G1 box; other site
324925005207	GTP/Mg2+ binding site [chemical binding]; other site
324925005208	Switch I region; other site
324925005209	G2 box; other site
324925005210	G3 box; other site
324925005211	Switch II region; other site
324925005212	G4 box; other site
324925005213	G5 box; other site
324925005214	Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683
324925005215	active site lid residues [active]
324925005216	substrate binding pocket [chemical binding]; other site
324925005217	catalytic residues [active]
324925005218	substrate-Mg2+ binding site; other site
324925005219	aspartate-rich region 1; other site
324925005220	aspartate-rich region 2; other site
324925005221	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
324925005222	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
324925005223	dimer interface [polypeptide binding]; other site
324925005224	putative anticodon binding site; other site
324925005225	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
324925005226	motif 1; other site
324925005227	active site
324925005228	motif 2; other site
324925005229	motif 3; other site
324925005230	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780
324925005231	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
324925005232	active site
324925005233	NTP binding site [chemical binding]; other site
324925005234	metal binding triad [ion binding]; metal-binding site
324925005235	antibiotic binding site [chemical binding]; other site
324925005236	PemK-like protein; Region: PemK; pfam02452
324925005237	Protein of unknown function, DUF488; Region: DUF488; pfam04343
324925005238	Protein of unknown function, DUF488; Region: DUF488; pfam04343
324925005239	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
324925005240	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cd09852
324925005241	putative active site [active]
324925005242	shikimate kinase; Provisional; Region: PRK13947
324925005243	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
324925005244	active site
324925005245	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
324925005246	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
324925005247	putative NAD(P) binding site [chemical binding]; other site
324925005248	active site
324925005249	putative substrate binding site [chemical binding]; other site
324925005250	Uncharacterized conserved protein [Function unknown]; Region: COG2308
324925005251	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307
324925005252	A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168
324925005253	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
324925005254	Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379
324925005255	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
324925005256	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
324925005257	Uncharacterized protein family (UPF0227); Region: UPF0227; cl14886
324925005258	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
324925005259	Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858
324925005260	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
324925005261	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
324925005262	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
324925005263	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
324925005264	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
324925005265	FeS/SAM binding site; other site
324925005266	putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574
324925005267	Uncharacterized conserved protein [Function unknown]; Region: COG2128
324925005268	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
324925005269	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
324925005270	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
324925005271	catalytic triad [active]
324925005272	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
324925005273	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
324925005274	catalytic triad [active]
324925005275	shikimate kinase; Reviewed; Region: aroK; PRK00131
324925005276	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
324925005277	ADP binding site [chemical binding]; other site
324925005278	magnesium binding site [ion binding]; other site
324925005279	putative shikimate binding site; other site
324925005280	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
324925005281	active site
324925005282	dimer interface [polypeptide binding]; other site
324925005283	metal binding site [ion binding]; metal-binding site
324925005284	pantothenate kinase; Reviewed; Region: PRK13320
324925005285	Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437
324925005286	Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968
324925005287	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
324925005288	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
324925005289	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
324925005290	dimerization interface [polypeptide binding]; other site
324925005291	putative DNA binding site [nucleotide binding]; other site
324925005292	putative Zn2+ binding site [ion binding]; other site
324925005293	AsnC family; Region: AsnC_trans_reg; pfam01037
324925005294	phytoene desaturase; Region: phytoene_desat; TIGR02731
324925005295	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
324925005296	transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282
324925005297	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
324925005298	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
324925005299	Probable Catalytic site; other site
324925005300	chlorosome envelope protein H repeat; Region: rpt_csmH; TIGR03058
324925005301	chlorosome envelope protein H repeat; Region: rpt_csmH; TIGR03058
324925005302	chlorosome envelope protein H repeat; Region: rpt_csmH; TIGR03058
324925005303	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
324925005304	trimer interface [polypeptide binding]; other site
324925005305	active site
324925005306	bacillithiol biosynthesis deacetylase BshB1; Region: thiol_BshB1; TIGR04001
324925005307	PBP superfamily domain; Region: PBP_like_2; cl17296
324925005308	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
324925005309	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
324925005310	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
324925005311	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
324925005312	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
324925005313	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
324925005314	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
324925005315	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
324925005316	ThiC-associated domain; Region: ThiC-associated; pfam13667
324925005317	ThiC family; Region: ThiC; pfam01964
324925005318	triosephosphate isomerase; Provisional; Region: PRK14567
324925005319	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
324925005320	substrate binding site [chemical binding]; other site
324925005321	dimer interface [polypeptide binding]; other site
324925005322	catalytic triad [active]
324925005323	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
324925005324	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
324925005325	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
324925005326	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
324925005327	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
324925005328	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
324925005329	protein binding site [polypeptide binding]; other site
324925005330	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
324925005331	protein binding site [polypeptide binding]; other site
324925005332	anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564
324925005333	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
324925005334	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
324925005335	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
324925005336	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
324925005337	Catalytic site [active]
324925005338	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
324925005339	GTP-binding protein LepA; Provisional; Region: PRK05433
324925005340	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
324925005341	G1 box; other site
324925005342	putative GEF interaction site [polypeptide binding]; other site
324925005343	GTP/Mg2+ binding site [chemical binding]; other site
324925005344	Switch I region; other site
324925005345	G2 box; other site
324925005346	G3 box; other site
324925005347	Switch II region; other site
324925005348	G4 box; other site
324925005349	G5 box; other site
324925005350	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
324925005351	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
324925005352	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
324925005353	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
324925005354	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
324925005355	putative active site [active]
324925005356	substrate binding site [chemical binding]; other site
324925005357	putative cosubstrate binding site; other site
324925005358	catalytic site [active]
324925005359	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
324925005360	substrate binding site [chemical binding]; other site
324925005361	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
324925005362	active site
324925005363	catalytic residues [active]
324925005364	metal binding site [ion binding]; metal-binding site
324925005365	Response regulator receiver domain; Region: Response_reg; pfam00072
324925005366	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
324925005367	active site
324925005368	phosphorylation site [posttranslational modification]
324925005369	intermolecular recognition site; other site
324925005370	dimerization interface [polypeptide binding]; other site
324925005371	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
324925005372	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
324925005373	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
324925005374	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
324925005375	active site
324925005376	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
324925005377	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
324925005378	magnesium chelatase, H subunit; Region: BchH; TIGR02025
324925005379	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
324925005380	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
324925005381	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
324925005382	magnesium chelatase ATPase subunit D; Region: BchD-ChlD; TIGR02031
324925005383	Walker A motif; other site
324925005384	ATP binding site [chemical binding]; other site
324925005385	Walker B motif; other site
324925005386	arginine finger; other site
324925005387	Magnesium chelatase: Mg-chelatase catalyses the insertion of Mg into protoporphyrin IX (Proto). In chlorophyll biosynthesis, insertion of Mg2+ into protoporphyrin IX is catalysed by magnesium chelatase in an ATP-dependent reaction. Magnesium chelatase is...; Region: vWA_Magnesium_chelatase; cd01451
324925005388	metal ion-dependent adhesion site (MIDAS); other site
324925005389	Mg-protoporyphyrin IX chelatase; Region: chlI; CHL00081
324925005390	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
324925005391	Walker A/P-loop; other site
324925005392	ATP binding site [chemical binding]; other site
324925005393	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
324925005394	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
324925005395	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
324925005396	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
324925005397	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
324925005398	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
324925005399	RNA binding surface [nucleotide binding]; other site
324925005400	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
324925005401	active site
324925005402	PAS domain S-box; Region: sensory_box; TIGR00229
324925005403	PAS domain S-box; Region: sensory_box; TIGR00229
324925005404	PAS domain; Region: PAS_8; pfam13188
324925005405	PAS fold; Region: PAS_4; pfam08448
324925005406	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
324925005407	putative active site [active]
324925005408	heme pocket [chemical binding]; other site
324925005409	PAS fold; Region: PAS_3; pfam08447
324925005410	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
324925005411	PAS domain; Region: PAS; smart00091
324925005412	PAS fold; Region: PAS_4; pfam08448
324925005413	PAS domain S-box; Region: sensory_box; TIGR00229
324925005414	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
324925005415	putative active site [active]
324925005416	heme pocket [chemical binding]; other site
324925005417	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
324925005418	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
324925005419	ATP binding site [chemical binding]; other site
324925005420	Mg2+ binding site [ion binding]; other site
324925005421	G-X-G motif; other site
324925005422	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
324925005423	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
324925005424	active site
324925005425	phosphorylation site [posttranslational modification]
324925005426	intermolecular recognition site; other site
324925005427	dimerization interface [polypeptide binding]; other site
324925005428	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
324925005429	Walker A motif; other site
324925005430	ATP binding site [chemical binding]; other site
324925005431	Walker B motif; other site
324925005432	arginine finger; other site
324925005433	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
324925005434	Gas vesicle protein K; Region: GvpK; pfam05121
324925005435	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
324925005436	Gas vesicle protein; Region: Gas_vesicle; pfam00741
324925005437	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
324925005438	Gas vesicle protein G; Region: GvpG; pfam05120
324925005439	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
324925005440	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
324925005441	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
324925005442	DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271
324925005443	HSP70 interaction site [polypeptide binding]; other site
324925005444	AAA family ATPase, CDC48 subfamily; Region: CDC48; TIGR01243
324925005445	Cell division protein 48 (CDC48), N-terminal domain; Region: CDC48_N; pfam02359
324925005446	Cell division protein 48 (CDC48), domain 2; Region: CDC48_2; pfam02933
324925005447	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
324925005448	Walker A motif; other site
324925005449	ATP binding site [chemical binding]; other site
324925005450	Walker B motif; other site
324925005451	arginine finger; other site
324925005452	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
324925005453	Walker A motif; other site
324925005454	ATP binding site [chemical binding]; other site
324925005455	Walker B motif; other site
324925005456	arginine finger; other site
324925005457	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
324925005458	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
324925005459	putative dimer interface [polypeptide binding]; other site
324925005460	Gas vesicle protein; Region: Gas_vesicle; pfam00741
324925005461	gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640
324925005462	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
324925005463	Walker A motif; other site
324925005464	ATP binding site [chemical binding]; other site
324925005465	Walker B motif; other site
324925005466	arginine finger; other site
324925005467	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
324925005468	gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371
324925005469	gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371
324925005470	gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371
324925005471	gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371
324925005472	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
324925005473	A new structural DNA glycosylase; Region: AlkD_like; cd06561
324925005474	active site
324925005475	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
324925005476	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
324925005477	Walker A/P-loop; other site
324925005478	ATP binding site [chemical binding]; other site
324925005479	Q-loop/lid; other site
324925005480	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
324925005481	ABC transporter signature motif; other site
324925005482	Walker B; other site
324925005483	D-loop; other site
324925005484	ABC transporter; Region: ABC_tran_2; pfam12848
324925005485	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
324925005486	PAS domain S-box; Region: sensory_box; TIGR00229
324925005487	PAS domain; Region: PAS; smart00091
324925005488	putative active site [active]
324925005489	heme pocket [chemical binding]; other site
324925005490	PAS domain S-box; Region: sensory_box; TIGR00229
324925005491	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
324925005492	putative active site [active]
324925005493	heme pocket [chemical binding]; other site
324925005494	PAS domain S-box; Region: sensory_box; TIGR00229
324925005495	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
324925005496	putative active site [active]
324925005497	heme pocket [chemical binding]; other site
324925005498	PAS fold; Region: PAS_4; pfam08448
324925005499	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
324925005500	putative active site [active]
324925005501	heme pocket [chemical binding]; other site
324925005502	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
324925005503	dimer interface [polypeptide binding]; other site
324925005504	phosphorylation site [posttranslational modification]
324925005505	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
324925005506	ATP binding site [chemical binding]; other site
324925005507	Mg2+ binding site [ion binding]; other site
324925005508	G-X-G motif; other site
324925005509	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
324925005510	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
324925005511	Walker A/P-loop; other site
324925005512	ATP binding site [chemical binding]; other site
324925005513	Q-loop/lid; other site
324925005514	ABC transporter signature motif; other site
324925005515	Walker B; other site
324925005516	D-loop; other site
324925005517	H-loop/switch region; other site
324925005518	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
324925005519	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
324925005520	Walker A/P-loop; other site
324925005521	ATP binding site [chemical binding]; other site
324925005522	Q-loop/lid; other site
324925005523	ABC transporter signature motif; other site
324925005524	Walker B; other site
324925005525	D-loop; other site
324925005526	H-loop/switch region; other site
324925005527	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
324925005528	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
324925005529	TM-ABC transporter signature motif; other site
324925005530	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
324925005531	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
324925005532	TM-ABC transporter signature motif; other site
324925005533	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
324925005534	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
324925005535	Cupin domain; Region: Cupin_2; pfam07883
324925005536	Glutamate-cysteine ligase family 2(GCS2); Region: GCS2; cl00954
324925005537	Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_6; cd06256
324925005538	putative active site [active]
324925005539	Zn binding site [ion binding]; other site
324925005540	putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830
324925005541	Methyltransferase domain; Region: Methyltransf_31; pfam13847
324925005542	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
324925005543	S-adenosylmethionine binding site [chemical binding]; other site
324925005544	Predicted thiol-disulfide oxidoreductase [General function    prediction only]; Region: COG3011
324925005545	toxin interface [polypeptide binding]; other site
324925005546	putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830
324925005547	YgiT-type zinc finger domain; Region: YgiT_finger; TIGR03831
324925005548	Zn binding site [ion binding]; other site
324925005549	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
324925005550	non-specific DNA binding site [nucleotide binding]; other site
324925005551	salt bridge; other site
324925005552	sequence-specific DNA binding site [nucleotide binding]; other site
324925005553	Motility quorum-sensing regulator (MqsR); Region: MqsR; cd12869
324925005554	peptide binding site [polypeptide binding]; other site
324925005555	Protein of unknown function (DUF1778); Region: DUF1778; pfam08681
324925005556	Protein of unknown function (DUF1044); Region: DUF1044; pfam06296
324925005557	Predicted transcriptional regulator [Transcription]; Region: COG2944
324925005558	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
324925005559	non-specific DNA binding site [nucleotide binding]; other site
324925005560	salt bridge; other site
324925005561	sequence-specific DNA binding site [nucleotide binding]; other site
324925005562	Predicted transcription regulator containing HTH domain [Transcription]; Region: COG5499
324925005563	TIGR02646 family protein; Region: TIGR02646
324925005564	Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950
324925005565	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
324925005566	Walker A/P-loop; other site
324925005567	ATP binding site [chemical binding]; other site
324925005568	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
324925005569	non-specific DNA binding site [nucleotide binding]; other site
324925005570	salt bridge; other site
324925005571	sequence-specific DNA binding site [nucleotide binding]; other site
324925005572	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
324925005573	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
324925005574	catalytic residues [active]
324925005575	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
324925005576	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
324925005577	active site
324925005578	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
324925005579	GTP cyclohydrolase I; Provisional; Region: PLN03044
324925005580	homodecamer interface [polypeptide binding]; other site
324925005581	active site
324925005582	putative catalytic site residues [active]
324925005583	zinc binding site [ion binding]; other site
324925005584	GTP-CH-I/GFRP interaction surface; other site
324925005585	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
324925005586	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
324925005587	putative substrate-binding site; other site
324925005588	nickel binding site [ion binding]; other site
324925005589	Ni/Fe-hydrogenase, b-type cytochrome subunit; Region: CytB-hydogenase; TIGR02125
324925005590	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
324925005591	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
324925005592	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
324925005593	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
324925005594	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
324925005595	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
324925005596	proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972
324925005597	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
324925005598	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
324925005599	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
324925005600	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
324925005601	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
324925005602	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
324925005603	NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971
324925005604	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
324925005605	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
324925005606	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
324925005607	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
324925005608	NADH dehydrogenase subunit D; Validated; Region: PRK06075
324925005609	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
324925005610	NADH dehydrogenase subunit B; Provisional; Region: PRK14813
324925005611	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
324925005612	TPR repeat; Region: TPR_11; pfam13414
324925005613	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925005614	binding surface
324925005615	TPR motif; other site
324925005616	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925005617	binding surface
324925005618	TPR repeat; Region: TPR_11; pfam13414
324925005619	TPR motif; other site
324925005620	Ferrochelatase; Region: Ferrochelatase; pfam00762
324925005621	Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784
324925005622	active site
324925005623	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
324925005624	active site
324925005625	N-terminal domain interface [polypeptide binding]; other site
324925005626	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
324925005627	nucleotide binding site/active site [active]
324925005628	HIT family signature motif; other site
324925005629	catalytic residue [active]
324925005630	Methyltransferase domain; Region: Methyltransf_31; pfam13847
324925005631	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
324925005632	S-adenosylmethionine binding site [chemical binding]; other site
324925005633	HTH-like domain; Region: HTH_21; pfam13276
324925005634	insertion element IS2 transposase InsD; Provisional; Region: PRK14702
324925005635	Integrase core domain; Region: rve; pfam00665
324925005636	Integrase core domain; Region: rve_3; pfam13683
324925005637	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
324925005638	Transposase; Region: HTH_Tnp_1; cl17663
324925005639	Predicted ATPase [General function prediction only]; Region: COG4637
324925005640	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
324925005641	Walker A/P-loop; other site
324925005642	ATP binding site [chemical binding]; other site
324925005643	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
324925005644	recombination factor protein RarA; Reviewed; Region: PRK13342
324925005645	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
324925005646	Walker A motif; other site
324925005647	ATP binding site [chemical binding]; other site
324925005648	Walker B motif; other site
324925005649	arginine finger; other site
324925005650	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
324925005651	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
324925005652	Lumazine binding domain; Region: Lum_binding; pfam00677
324925005653	Lumazine binding domain; Region: Lum_binding; pfam00677
324925005654	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_5; cd11352
324925005655	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
324925005656	active site
324925005657	catalytic site [active]
324925005658	Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014
324925005659	dimer interface [polypeptide binding]; other site
324925005660	catalytic triad [active]
324925005661	peroxidatic and resolving cysteines [active]
324925005662	DoxX; Region: DoxX; pfam07681
324925005663	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
324925005664	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
324925005665	catalytic motif [active]
324925005666	Zn binding site [ion binding]; other site
324925005667	RibD C-terminal domain; Region: RibD_C; cl17279
324925005668	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
324925005669	catalytic motif [active]
324925005670	Zn binding site [ion binding]; other site
324925005671	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
324925005672	Domain of unknown function (DUF814); Region: DUF814; pfam05670
324925005673	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
324925005674	Ligand Binding Site [chemical binding]; other site
324925005675	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
324925005676	Natural resistance-associated macrophage protein; Region: Nramp; pfam01566
324925005677	Predicted flavoprotein [General function prediction only]; Region: COG0431
324925005678	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
324925005679	Protein of unknown function (DUF1625); Region: DUF1625; pfam07787
324925005680	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
324925005681	Predicted permeases [General function prediction only]; Region: COG0795
324925005682	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
324925005683	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
324925005684	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
324925005685	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
324925005686	Protein of unknown function (DUF1044); Region: DUF1044; cl01955
324925005687	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
324925005688	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
324925005689	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
324925005690	catalytic triad [active]
324925005691	DNA photolyase; Region: DNA_photolyase; pfam00875
324925005692	PBP superfamily domain; Region: PBP_like_2; cl17296
324925005693	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
324925005694	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
324925005695	ligand binding site [chemical binding]; other site
324925005696	Tubulin like; Region: Tubulin_2; pfam13809
324925005697	ribonuclease R; Region: RNase_R; TIGR02063
324925005698	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
324925005699	RNB domain; Region: RNB; pfam00773
324925005700	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
324925005701	RNA binding site [nucleotide binding]; other site
324925005702	Uncharacterized protein family, UPF0114; Region: UPF0114; pfam03350
324925005703	Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598
324925005704	Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
324925005705	oligomer interface [polypeptide binding]; other site
324925005706	metal binding site [ion binding]; metal-binding site
324925005707	metal binding site [ion binding]; metal-binding site
324925005708	Cl binding site [ion binding]; other site
324925005709	aspartate ring; other site
324925005710	basic sphincter; other site
324925005711	putative hydrophobic gate; other site
324925005712	periplasmic entrance; other site
324925005713	putative phosphoketolase; Provisional; Region: PRK05261
324925005714	Thiamine pyrophosphate (TPP) family, Phosphoketolase (PK) subfamily, TPP-binding module; PK catalyzes the conversion of D-xylulose 5-phosphate and phosphate to acetyl phosphate, D-glyceraldehyde-3-phosphate and H2O. This enzyme requires divalent...; Region: TPP_PK; cd02011
324925005715	TPP-binding site; other site
324925005716	XFP C-terminal domain; Region: XFP_C; pfam09363
324925005717	propionate/acetate kinase; Provisional; Region: PRK12379
324925005718	Acetokinase family; Region: Acetate_kinase; cl17229
324925005719	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
324925005720	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
324925005721	non-specific DNA binding site [nucleotide binding]; other site
324925005722	salt bridge; other site
324925005723	sequence-specific DNA binding site [nucleotide binding]; other site
324925005724	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
324925005725	short chain dehydrogenase; Provisional; Region: PRK08267
324925005726	classical (c) SDRs; Region: SDR_c; cd05233
324925005727	NAD(P) binding site [chemical binding]; other site
324925005728	active site
324925005729	homocitrate synthase NifV; Region: nifV_homocitr; TIGR02660
324925005730	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
324925005731	active site
324925005732	catalytic residues [active]
324925005733	metal binding site [ion binding]; metal-binding site
324925005734	Nif-specific regulatory protein; Region: nifA; TIGR01817
324925005735	GAF domain; Region: GAF; pfam01590
324925005736	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
324925005737	Walker A motif; other site
324925005738	ATP binding site [chemical binding]; other site
324925005739	Walker B motif; other site
324925005740	arginine finger; other site
324925005741	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
324925005742	rod shape-determining protein MreB; Provisional; Region: PRK13930
324925005743	MreB and similar proteins; Region: MreB_like; cd10225
324925005744	nucleotide binding site [chemical binding]; other site
324925005745	Mg binding site [ion binding]; other site
324925005746	putative protofilament interaction site [polypeptide binding]; other site
324925005747	RodZ interaction site [polypeptide binding]; other site
324925005748	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
324925005749	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
324925005750	active site
324925005751	catalytic tetrad [active]
324925005752	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
324925005753	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304
324925005754	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
324925005755	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
324925005756	non-specific DNA binding site [nucleotide binding]; other site
324925005757	salt bridge; other site
324925005758	sequence-specific DNA binding site [nucleotide binding]; other site
324925005759	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
324925005760	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
324925005761	TIR domain; Region: TIR_2; pfam13676
324925005762	Glycosyl hydrolases family 16; Region: Glyco_hydro_16; pfam00722
324925005763	active site
324925005764	catalytic residues [active]
324925005765	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
324925005766	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
324925005767	TIR domain; Region: TIR_2; pfam13676
324925005768	Uncharacterized conserved protein [Function unknown]; Region: COG1262
324925005769	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
324925005770	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
324925005771	Uncharacterized conserved protein [Function unknown]; Region: COG1262
324925005772	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
324925005773	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
324925005774	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
324925005775	Walker A motif; other site
324925005776	ATP binding site [chemical binding]; other site
324925005777	Walker B motif; other site
324925005778	arginine finger; other site
324925005779	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
324925005780	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
324925005781	nitrogenase reductase; Reviewed; Region: nifH; PRK13235
324925005782	NifH gene encodes component II (iron protein) of nitrogenase. Nitrogenase is responsible for the biological nitrogen fixation, i.e. reduction of molecular nitrogen to ammonia. NifH consists of two oxygen-sensitive metallosulfur proteins: the...; Region: NifH; cd02040
324925005783	Nucleotide-binding sites [chemical binding]; other site
324925005784	Walker A motif; other site
324925005785	Switch I region of nucleotide binding site; other site
324925005786	Fe4S4 binding sites [ion binding]; other site
324925005787	Switch II region of nucleotide binding site; other site
324925005788	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
324925005789	Nitrogen regulatory protein P-II; Region: P-II; smart00938
324925005790	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
324925005791	Nitrogen regulatory protein P-II; Region: P-II; smart00938
324925005792	nitrogenase alpha chain; Region: alt_nitrog_alph; TIGR01284
324925005793	Nitrogenase_MoFe_alpha_II: Nitrogenase MoFe protein, beta subunit. A group of proteins similar to the alpha subunit of the MoFe protein of the molybdenum (Mo-) nitrogenase. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to...; Region: Nitrogenase_MoFe_alpha; cd01976
324925005794	MoFe protein alpha/beta subunit interactions; other site
324925005795	Alpha subunit P cluster binding residues; other site
324925005796	FeMoco binding residues [chemical binding]; other site
324925005797	MoFe protein alpha subunit/Fe protein contacts; other site
324925005798	MoFe protein dimer/ dimer interactions; other site
324925005799	Nitrogenase_MoFe_beta: Nitrogenase MoFe protein, beta subunit. The nitrogenase enzyme catalyzes the ATP-dependent reduction of dinitrogen to ammonia. The Molybdenum (Mo-) nitrogenase is the most widespread and best characterized of these systems; Region: Nitrogenase_MoFe_beta; cd01974
324925005800	MoFe protein beta/alpha subunit interactions; other site
324925005801	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
324925005802	Beta subunit P cluster binding residues; other site
324925005803	MoFe protein beta subunit/Fe protein contacts; other site
324925005804	MoFe protein dimer/ dimer interactions; other site
324925005805	nitrogenase molybdenum-iron cofactor biosynthesis protein NifE; Region: nifE; TIGR01283
324925005806	Nitrogenase_NifE_I: a subgroup of the NifE subunit of the NifEN complex: NifE forms an alpha2beta2 tetramer with NifN.  NifE and NifN are structurally homologous to nitrogenase MoFe protein alpha and beta subunits respectively.  NifEN participates in the...; Region: Nitrogenase_NifE_I; cd01968
324925005807	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
324925005808	Nitrogenase component 1 type Oxidoreductase; Region: Oxidored_nitro; pfam00148
324925005809	nitrogenase cofactor biosynthesis protein NifB; Region: nifB; TIGR01290
324925005810	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
324925005811	FeS/SAM binding site; other site
324925005812	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
324925005813	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
324925005814	dimer interface [polypeptide binding]; other site
324925005815	[2Fe-2S] cluster binding site [ion binding]; other site
324925005816	AAA domain; Region: AAA_22; pfam13401
324925005817	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
324925005818	Walker A motif; other site
324925005819	ATP binding site [chemical binding]; other site
324925005820	Walker B motif; other site
324925005821	arginine finger; other site
324925005822	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
324925005823	heat shock protein HtpX; Provisional; Region: PRK05457
324925005824	octaheme c-type cytochrome, tetrathionate reductase family; Region: octaheme_Shew; TIGR04315
324925005825	Cytochrome c bacterial; Region: Cytochrome_cB; pfam11783
324925005826	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
324925005827	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
324925005828	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
324925005829	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
324925005830	Sel1-like repeats; Region: SEL1; smart00671
324925005831	Sel1-like repeats; Region: SEL1; smart00671
324925005832	Protein of unknown function (DUF4019); Region: DUF4019; pfam13211
324925005833	Fic family protein [Function unknown]; Region: COG3177
324925005834	Fic/DOC family; Region: Fic; pfam02661
324925005835	Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163
324925005836	TPR repeat; Region: TPR_11; pfam13414
324925005837	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925005838	binding surface
324925005839	TPR motif; other site
324925005840	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
324925005841	Uncharacterized conserved protein [Function unknown]; Region: COG1262
324925005842	Homeodomain-like domain; Region: HTH_23; pfam13384
324925005843	Winged helix-turn helix; Region: HTH_29; pfam13551
324925005844	Homeodomain-like domain; Region: HTH_32; pfam13565
324925005845	DDE superfamily endonuclease; Region: DDE_3; pfam13358
324925005846	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
324925005847	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
324925005848	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
324925005849	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
324925005850	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
324925005851	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
324925005852	DNA methylase; Region: N6_N4_Mtase; pfam01555
324925005853	DNA methylase; Region: N6_N4_Mtase; pfam01555
324925005854	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
324925005855	non-specific DNA binding site [nucleotide binding]; other site
324925005856	salt bridge; other site
324925005857	sequence-specific DNA binding site [nucleotide binding]; other site
324925005858	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
324925005859	ATP binding site [chemical binding]; other site
324925005860	putative Mg++ binding site [ion binding]; other site
324925005861	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
324925005862	nucleotide binding region [chemical binding]; other site
324925005863	ATP-binding site [chemical binding]; other site
324925005864	PAS domain S-box; Region: sensory_box; TIGR00229
324925005865	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
324925005866	putative active site [active]
324925005867	heme pocket [chemical binding]; other site
324925005868	histidine kinase; Provisional; Region: PRK13557
324925005869	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
324925005870	putative active site [active]
324925005871	heme pocket [chemical binding]; other site
324925005872	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
324925005873	dimer interface [polypeptide binding]; other site
324925005874	phosphorylation site [posttranslational modification]
324925005875	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
324925005876	ATP binding site [chemical binding]; other site
324925005877	Mg2+ binding site [ion binding]; other site
324925005878	G-X-G motif; other site
324925005879	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
324925005880	active site
324925005881	phosphorylation site [posttranslational modification]
324925005882	intermolecular recognition site; other site
324925005883	dimerization interface [polypeptide binding]; other site
324925005884	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
324925005885	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
324925005886	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
324925005887	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
324925005888	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
324925005889	thiamine ABC transporter, ATP-binding protein; Region: thiQ; TIGR01277
324925005890	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
324925005891	Walker A/P-loop; other site
324925005892	ATP binding site [chemical binding]; other site
324925005893	Q-loop/lid; other site
324925005894	ABC transporter signature motif; other site
324925005895	Walker B; other site
324925005896	D-loop; other site
324925005897	H-loop/switch region; other site
324925005898	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
324925005899	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
324925005900	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
324925005901	Periplasmic binding protein TroA_e.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142
324925005902	putative ligand binding residues [chemical binding]; other site
324925005903	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
324925005904	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
324925005905	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
324925005906	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
324925005907	Walker A/P-loop; other site
324925005908	ATP binding site [chemical binding]; other site
324925005909	Q-loop/lid; other site
324925005910	ABC transporter signature motif; other site
324925005911	Walker B; other site
324925005912	D-loop; other site
324925005913	H-loop/switch region; other site
324925005914	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
324925005915	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
324925005916	ABC-ATPase subunit  interface; other site
324925005917	dimer interface [polypeptide binding]; other site
324925005918	putative PBP binding regions; other site
324925005919	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
324925005920	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
324925005921	Walker A/P-loop; other site
324925005922	ATP binding site [chemical binding]; other site
324925005923	Q-loop/lid; other site
324925005924	ABC transporter signature motif; other site
324925005925	Walker B; other site
324925005926	D-loop; other site
324925005927	H-loop/switch region; other site
324925005928	Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585
324925005929	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
324925005930	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
324925005931	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
324925005932	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
324925005933	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
324925005934	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
324925005935	dimer interface [polypeptide binding]; other site
324925005936	conserved gate region; other site
324925005937	putative PBP binding loops; other site
324925005938	ABC-ATPase subunit interface; other site
324925005939	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
324925005940	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
324925005941	dimer interface [polypeptide binding]; other site
324925005942	pyridoxal 5'-phosphate binding site [chemical binding]; other site
324925005943	catalytic residue [active]
324925005944	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
324925005945	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
324925005946	homodimer interface [polypeptide binding]; other site
324925005947	substrate-cofactor binding pocket; other site
324925005948	pyridoxal 5'-phosphate binding site [chemical binding]; other site
324925005949	catalytic residue [active]
324925005950	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
324925005951	thiS-thiF/thiG interaction site; other site
324925005952	thiazole synthase; Reviewed; Region: thiG; PRK00208
324925005953	phosphate binding site [ion binding]; other site
324925005954	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
324925005955	Radical SAM superfamily; Region: Radical_SAM; pfam04055
324925005956	FeS/SAM binding site; other site
324925005957	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
324925005958	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
324925005959	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
324925005960	ATP binding site [chemical binding]; other site
324925005961	substrate interface [chemical binding]; other site
324925005962	Protein of unknown function (DUF3307); Region: DUF3307; pfam11750
324925005963	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925005964	TPR repeat; Region: TPR_11; pfam13414
324925005965	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925005966	binding surface
324925005967	TPR motif; other site
324925005968	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925005969	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925005970	binding surface
324925005971	TPR motif; other site
324925005972	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925005973	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925005974	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
324925005975	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
324925005976	TPP-binding site [chemical binding]; other site
324925005977	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
324925005978	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
324925005979	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
324925005980	E3 interaction surface; other site
324925005981	lipoyl attachment site [posttranslational modification]; other site
324925005982	e3 binding domain; Region: E3_binding; pfam02817
324925005983	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
324925005984	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
324925005985	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
324925005986	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
324925005987	Helix-turn-helix domain; Region: HTH_28; pfam13518
324925005988	Winged helix-turn helix; Region: HTH_29; pfam13551
324925005989	Homeodomain-like domain; Region: HTH_32; pfam13565
324925005990	DDE superfamily endonuclease; Region: DDE_3; pfam13358
324925005991	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
324925005992	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
324925005993	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
324925005994	TM-ABC transporter signature motif; other site
324925005995	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
324925005996	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
324925005997	TM-ABC transporter signature motif; other site
324925005998	Homeodomain-like domain; Region: HTH_23; pfam13384
324925005999	Winged helix-turn helix; Region: HTH_29; pfam13551
324925006000	Homeodomain-like domain; Region: HTH_32; pfam13565
324925006001	DDE superfamily endonuclease; Region: DDE_3; pfam13358
324925006002	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
324925006003	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
324925006004	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
324925006005	B12 binding site [chemical binding]; other site
324925006006	Radical SAM superfamily; Region: Radical_SAM; pfam04055
324925006007	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
324925006008	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
324925006009	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
324925006010	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
324925006011	Walker A/P-loop; other site
324925006012	ATP binding site [chemical binding]; other site
324925006013	Q-loop/lid; other site
324925006014	ABC transporter signature motif; other site
324925006015	Walker B; other site
324925006016	D-loop; other site
324925006017	H-loop/switch region; other site
324925006018	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
324925006019	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
324925006020	Walker A/P-loop; other site
324925006021	ATP binding site [chemical binding]; other site
324925006022	Q-loop/lid; other site
324925006023	ABC transporter signature motif; other site
324925006024	Walker B; other site
324925006025	D-loop; other site
324925006026	H-loop/switch region; other site
324925006027	Transposase [DNA replication, recombination, and repair]; Region: COG5421
324925006028	Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422
324925006029	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
324925006030	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
324925006031	sequence-specific DNA binding site [nucleotide binding]; other site
324925006032	salt bridge; other site
324925006033	Cellular and retroviral pepsin-like aspartate proteases; Region: pepsin_retropepsin_like; cl11403
324925006034	inhibitor binding site; inhibition site
324925006035	catalytic motif [active]
324925006036	Catalytic residue [active]
324925006037	Active site flap [active]
324925006038	Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849
324925006039	hypothetical protein; Provisional; Region: PRK05968
324925006040	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
324925006041	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
324925006042	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
324925006043	TIGR02687 family protein; Region: TIGR02687
324925006044	PglZ domain; Region: PglZ; pfam08665
324925006045	conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653
324925006046	Putative ATP-dependent Lon protease; Region: Lon_2; pfam13337
324925006047	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
324925006048	HipA-like N-terminal domain; Region: HipA_N; pfam07805
324925006049	HipA-like C-terminal domain; Region: HipA_C; pfam07804
324925006050	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
324925006051	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
324925006052	non-specific DNA binding site [nucleotide binding]; other site
324925006053	salt bridge; other site
324925006054	sequence-specific DNA binding site [nucleotide binding]; other site
324925006055	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
324925006056	dimerization interface [polypeptide binding]; other site
324925006057	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
324925006058	ATP binding site [chemical binding]; other site
324925006059	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
324925006060	hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075
324925006061	HupF/HypC family; Region: HupF_HypC; pfam01455
324925006062	Acylphosphatase; Region: Acylphosphatase; pfam00708
324925006063	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
324925006064	HypF finger; Region: zf-HYPF; pfam07503
324925006065	HypF finger; Region: zf-HYPF; pfam07503
324925006066	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
324925006067	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
324925006068	Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375
324925006069	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
324925006070	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
324925006071	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
324925006072	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
324925006073	Protein of unknown function (DUF1207); Region: DUF1207; pfam06727
324925006074	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
324925006075	nudix motif; other site
324925006076	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
324925006077	Ligand Binding Site [chemical binding]; other site
324925006078	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
324925006079	putative substrate translocation pore; other site
324925006080	excinuclease ABC subunit C; Provisional; Region: uvrC; PRK14671
324925006081	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
324925006082	GIY-YIG motif/motif A; other site
324925006083	active site
324925006084	catalytic site [active]
324925006085	putative DNA binding site [nucleotide binding]; other site
324925006086	metal binding site [ion binding]; metal-binding site
324925006087	UvrB/uvrC motif; Region: UVR; pfam02151
324925006088	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
324925006089	H3TH domains of structure-specific 5' nucleases (or flap endonuclease-1-like) involved in DNA replication, repair, and recombination; Region: H3TH_StructSpec-5'-nucleases; cl14815
324925006090	DNA binding site [nucleotide binding]
324925006091	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925006092	binding surface
324925006093	TPR motif; other site
324925006094	TPR repeat; Region: TPR_11; pfam13414
324925006095	TPR repeat; Region: TPR_11; pfam13414
324925006096	TPR repeat; Region: TPR_11; pfam13414
324925006097	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925006098	binding surface
324925006099	TPR motif; other site
324925006100	TPR repeat; Region: TPR_11; pfam13414
324925006101	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925006102	binding surface
324925006103	TPR repeat; Region: TPR_11; pfam13414
324925006104	TPR motif; other site
324925006105	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925006106	binding surface
324925006107	TPR motif; other site
324925006108	TPR repeat; Region: TPR_11; pfam13414
324925006109	TPR repeat; Region: TPR_11; pfam13414
324925006110	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
324925006111	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
324925006112	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
324925006113	shikimate binding site; other site
324925006114	NAD(P) binding site [chemical binding]; other site
324925006115	lipoprotein signal peptidase; Provisional; Region: PRK14787
324925006116	Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252
324925006117	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
324925006118	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
324925006119	active site
324925006120	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
324925006121	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
324925006122	active site
324925006123	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
324925006124	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
324925006125	catalytic residue [active]
324925006126	purine nucleoside phosphorylase; Provisional; Region: PRK08202
324925006127	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
324925006128	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
324925006129	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
324925006130	Low-spin heme binding site [chemical binding]; other site
324925006131	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
324925006132	D-pathway; other site
324925006133	Putative water exit pathway; other site
324925006134	Binuclear center (active site) [active]
324925006135	K-pathway; other site
324925006136	Putative proton exit pathway; other site
324925006137	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
324925006138	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
324925006139	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
324925006140	4Fe-4S binding domain; Region: Fer4_5; pfam12801
324925006141	4Fe-4S dicluster domain; Region: Fer4_18; pfam13746
324925006142	FixH; Region: FixH; pfam05751
324925006143	YtkA-like; Region: YtkA; pfam13115
324925006144	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
324925006145	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
324925006146	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
324925006147	metal-binding site [ion binding]
324925006148	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
324925006149	Soluble P-type ATPase [General function prediction only]; Region: COG4087
324925006150	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
324925006151	Family description; Region: DsbD_2; pfam13386
324925006152	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
324925006153	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
324925006154	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
324925006155	4-fold oligomerization interface [polypeptide binding]; other site
324925006156	putative active site pocket [active]
324925006157	metal binding residues [ion binding]; metal-binding site
324925006158	3-fold/trimer interface [polypeptide binding]; other site
324925006159	phosphodiesterase; Provisional; Region: PRK12704
324925006160	KH domain; Region: KH_1; pfam00013
324925006161	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
324925006162	Zn2+ binding site [ion binding]; other site
324925006163	Mg2+ binding site [ion binding]; other site
324925006164	Cell division protein ZapA; Region: ZapA; pfam05164
324925006165	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
324925006166	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
324925006167	putative tRNA-binding site [nucleotide binding]; other site
324925006168	B3/4 domain; Region: B3_4; pfam03483
324925006169	tRNA synthetase B5 domain; Region: B5; smart00874
324925006170	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
324925006171	dimer interface [polypeptide binding]; other site
324925006172	motif 1; other site
324925006173	motif 3; other site
324925006174	motif 2; other site
324925006175	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
324925006176	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
324925006177	nudix motif; other site
324925006178	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
324925006179	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
324925006180	active site
324925006181	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
324925006182	S-adenosylmethionine synthetase; Validated; Region: PRK05250
324925006183	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
324925006184	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
324925006185	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
324925006186	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
324925006187	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
324925006188	homotetramer interface [polypeptide binding]; other site
324925006189	ligand binding site [chemical binding]; other site
324925006190	catalytic site [active]
324925006191	NAD binding site [chemical binding]; other site
324925006192	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
324925006193	active site
324925006194	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
324925006195	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
324925006196	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
324925006197	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
324925006198	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
324925006199	TrkA-N domain; Region: TrkA_N; pfam02254
324925006200	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
324925006201	Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173
324925006202	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
324925006203	putative transporter; Provisional; Region: PRK11660
324925006204	Sulfate transporter family; Region: Sulfate_transp; pfam00916
324925006205	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
324925006206	Arsenate Reductase (ArsC) family, 15kD protein subfamily; composed of proteins of unknown function with similarity to thioredoxin-fold arsenic reductases, ArsC. It is encoded by an ORF present in a gene cluster associated with nitrogen fixation that also...; Region: ArsC_15kD; cd03033
324925006207	putative catalytic residues [active]
324925006208	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
324925006209	trimer interface [polypeptide binding]; other site
324925006210	putative Zn binding site [ion binding]; other site
324925006211	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
324925006212	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
324925006213	ATP binding site [chemical binding]; other site
324925006214	Mg++ binding site [ion binding]; other site
324925006215	motif III; other site
324925006216	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
324925006217	nucleotide binding region [chemical binding]; other site
324925006218	ATP-binding site [chemical binding]; other site
324925006219	Protein of unknown function DUF45; Region: DUF45; pfam01863
324925006220	Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053
324925006221	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
324925006222	homodimer interface [polypeptide binding]; other site
324925006223	substrate-cofactor binding pocket; other site
324925006224	pyridoxal 5'-phosphate binding site [chemical binding]; other site
324925006225	catalytic residue [active]
324925006226	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
324925006227	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
324925006228	putative active site [active]
324925006229	putative NTP binding site [chemical binding]; other site
324925006230	putative nucleic acid binding site [nucleotide binding]; other site
324925006231	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
324925006232	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
324925006233	S-adenosylmethionine binding site [chemical binding]; other site
324925006234	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
324925006235	YcfA-like protein; Region: YcfA; pfam07927
324925006236	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
324925006237	S-adenosylmethionine binding site [chemical binding]; other site
324925006238	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
324925006239	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
324925006240	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
324925006241	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
324925006242	non-specific DNA binding site [nucleotide binding]; other site
324925006243	salt bridge; other site
324925006244	sequence-specific DNA binding site [nucleotide binding]; other site
324925006245	Protein of unknown function (DUF499); Region: DUF499; pfam04465
324925006246	TIGR04255 family protein; Region: sporadTIGR04255
324925006247	PemK-like protein; Region: PemK; pfam02452
324925006248	Protein of unknown function (DUF1156); Region: DUF1156; pfam06634
324925006249	Methyltransferase domain; Region: Methyltransf_26; pfam13659
324925006250	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
324925006251	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
324925006252	ATP binding site [chemical binding]; other site
324925006253	putative Mg++ binding site [ion binding]; other site
324925006254	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
324925006255	nucleotide binding region [chemical binding]; other site
324925006256	ATP-binding site [chemical binding]; other site
324925006257	RES domain; Region: RES; pfam08808
324925006258	Transposase; Region: HTH_Tnp_1; cl17663
324925006259	Protein of unknown function (DUF2283); Region: DUF2283; pfam10049
324925006260	Uncharacterized ACR, COG1678; Region: DUF179; pfam02622
324925006261	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
324925006262	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
324925006263	catalytic triad [active]
324925006264	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
324925006265	nudix motif; other site
324925006266	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
324925006267	PAS domain; Region: PAS_9; pfam13426
324925006268	putative active site [active]
324925006269	heme pocket [chemical binding]; other site
324925006270	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
324925006271	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
324925006272	PAS domain S-box; Region: sensory_box; TIGR00229
324925006273	PAS domain S-box; Region: sensory_box; TIGR00229
324925006274	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
324925006275	putative active site [active]
324925006276	heme pocket [chemical binding]; other site
324925006277	GAF domain; Region: GAF_2; pfam13185
324925006278	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
324925006279	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
324925006280	dimer interface [polypeptide binding]; other site
324925006281	phosphorylation site [posttranslational modification]
324925006282	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
324925006283	ATP binding site [chemical binding]; other site
324925006284	Mg2+ binding site [ion binding]; other site
324925006285	G-X-G motif; other site
324925006286	Response regulator receiver domain; Region: Response_reg; pfam00072
324925006287	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
324925006288	active site
324925006289	phosphorylation site [posttranslational modification]
324925006290	intermolecular recognition site; other site
324925006291	dimerization interface [polypeptide binding]; other site
324925006292	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
324925006293	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
324925006294	Walker A/P-loop; other site
324925006295	ATP binding site [chemical binding]; other site
324925006296	Q-loop/lid; other site
324925006297	ABC transporter signature motif; other site
324925006298	Walker B; other site
324925006299	D-loop; other site
324925006300	H-loop/switch region; other site
324925006301	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
324925006302	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
324925006303	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
324925006304	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
324925006305	ATP binding site [chemical binding]; other site
324925006306	putative Mg++ binding site [ion binding]; other site
324925006307	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
324925006308	nucleotide binding region [chemical binding]; other site
324925006309	ATP-binding site [chemical binding]; other site
324925006310	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
324925006311	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
324925006312	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
324925006313	catalytic loop [active]
324925006314	iron binding site [ion binding]; other site
324925006315	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
324925006316	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
324925006317	catalytic loop [active]
324925006318	iron binding site [ion binding]; other site
324925006319	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
324925006320	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
324925006321	hexamer interface [polypeptide binding]; other site
324925006322	ligand binding site [chemical binding]; other site
324925006323	putative active site [active]
324925006324	NAD(P) binding site [chemical binding]; other site
324925006325	carotene isomerase; Region: carot_isom; TIGR02730
324925006326	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
324925006327	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
324925006328	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
324925006329	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
324925006330	DNA binding residues [nucleotide binding]
324925006331	Putative zinc-finger; Region: zf-HC2; pfam13490
324925006332	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
324925006333	dimerization interface [polypeptide binding]; other site
324925006334	putative DNA binding site [nucleotide binding]; other site
324925006335	putative Zn2+ binding site [ion binding]; other site
324925006336	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
324925006337	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
324925006338	putative dimer interface [polypeptide binding]; other site
324925006339	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
324925006340	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
324925006341	nucleotide binding site [chemical binding]; other site
324925006342	NEF interaction site [polypeptide binding]; other site
324925006343	SBD interface [polypeptide binding]; other site
324925006344	Photosystem P840 reaction centre protein PscD; Region: RC-P840_PscD; pfam10657
324925006345	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
324925006346	Tetratricopeptide repeat; Region: TPR_6; pfam13174
324925006347	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
324925006348	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
324925006349	ligand binding site [chemical binding]; other site
324925006350	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
324925006351	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
324925006352	ligand binding site [chemical binding]; other site
324925006353	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
324925006354	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
324925006355	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
324925006356	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
324925006357	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
324925006358	TonB C terminal; Region: TonB_2; pfam13103
324925006359	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
324925006360	TolR protein; Region: tolR; TIGR02801
324925006361	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
324925006362	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
324925006363	Integral membrane protein DUF92; Region: DUF92; pfam01940
324925006364	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
324925006365	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
324925006366	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
324925006367	PYR/PP interface [polypeptide binding]; other site
324925006368	dimer interface [polypeptide binding]; other site
324925006369	TPP binding site [chemical binding]; other site
324925006370	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
324925006371	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
324925006372	TPP-binding site [chemical binding]; other site
324925006373	dimer interface [polypeptide binding]; other site
324925006374	PAS domain; Region: PAS_9; pfam13426
324925006375	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
324925006376	putative active site [active]
324925006377	heme pocket [chemical binding]; other site
324925006378	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
324925006379	PAS fold; Region: PAS_3; pfam08447
324925006380	putative active site [active]
324925006381	heme pocket [chemical binding]; other site
324925006382	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
324925006383	PAS fold; Region: PAS_3; pfam08447
324925006384	putative active site [active]
324925006385	heme pocket [chemical binding]; other site
324925006386	PAS domain S-box; Region: sensory_box; TIGR00229
324925006387	PAS domain S-box; Region: sensory_box; TIGR00229
324925006388	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
324925006389	putative active site [active]
324925006390	heme pocket [chemical binding]; other site
324925006391	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
324925006392	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
324925006393	dimer interface [polypeptide binding]; other site
324925006394	phosphorylation site [posttranslational modification]
324925006395	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
324925006396	ATP binding site [chemical binding]; other site
324925006397	Mg2+ binding site [ion binding]; other site
324925006398	G-X-G motif; other site
324925006399	Response regulator receiver domain; Region: Response_reg; pfam00072
324925006400	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
324925006401	active site
324925006402	phosphorylation site [posttranslational modification]
324925006403	intermolecular recognition site; other site
324925006404	dimerization interface [polypeptide binding]; other site
324925006405	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
324925006406	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
324925006407	putative valine binding site [chemical binding]; other site
324925006408	dimer interface [polypeptide binding]; other site
324925006409	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
324925006410	ketol-acid reductoisomerase; Provisional; Region: PRK05479
324925006411	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
324925006412	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
324925006413	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
324925006414	tartrate dehydrogenase; Region: TTC; TIGR02089
324925006415	2-isopropylmalate synthase; Validated; Region: PRK00915
324925006416	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
324925006417	active site
324925006418	catalytic residues [active]
324925006419	metal binding site [ion binding]; metal-binding site
324925006420	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
324925006421	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
324925006422	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
324925006423	substrate binding site [chemical binding]; other site
324925006424	ligand binding site [chemical binding]; other site
324925006425	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
324925006426	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
324925006427	substrate binding site [chemical binding]; other site
324925006428	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
324925006429	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
324925006430	active site
324925006431	catalytic residues [active]
324925006432	metal binding site [ion binding]; metal-binding site
324925006433	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
324925006434	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
324925006435	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
324925006436	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
324925006437	putative active site [active]
324925006438	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
324925006439	Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910
324925006440	Lipocalin-like domain; Region: Lipocalin_2; pfam08212
324925006441	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
324925006442	NACHT domain; Region: NACHT; pfam05729
324925006443	Walker A/P-loop; other site
324925006444	ATP binding site [chemical binding]; other site
324925006445	Uncharacterized conserved protein [Function unknown]; Region: COG1262
324925006446	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
324925006447	Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910
324925006448	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
324925006449	RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646
324925006450	putative active site [active]
324925006451	putative NTP binding site [chemical binding]; other site
324925006452	putative nucleic acid binding site [nucleotide binding]; other site
324925006453	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
324925006454	NACHT domain; Region: NACHT; pfam05729
324925006455	Walker A/P-loop; other site
324925006456	ATP binding site [chemical binding]; other site
324925006457	Q-loop/lid; other site
324925006458	ABC transporter signature motif; other site
324925006459	Walker B; other site
324925006460	D-loop; other site
324925006461	Uncharacterized conserved protein [Function unknown]; Region: COG1262
324925006462	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
324925006463	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
324925006464	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
324925006465	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
324925006466	DNA methylase; Region: N6_N4_Mtase; pfam01555
324925006467	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
324925006468	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
324925006469	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
324925006470	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
324925006471	putative active site [active]
324925006472	putative substrate binding site [chemical binding]; other site
324925006473	putative cosubstrate binding site; other site
324925006474	catalytic site [active]
324925006475	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
324925006476	PAP2_like proteins, Lipid A 1-phosphatase subfamily. Lipid A 1-phosphatase, or LpxE from Francisella novicida selectively dephosphorylates lipid A at the 1-position. Lipid A is the membrane-anchor component of lipopolysaccharides (LPS), the major...; Region: PAP2_lipid_A_1_phosphatase; cd03389
324925006477	active site
324925006478	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
324925006479	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
324925006480	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
324925006481	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
324925006482	Ligand binding site; other site
324925006483	Putative Catalytic site; other site
324925006484	DXD motif; other site
324925006485	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
324925006486	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
324925006487	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
324925006488	DHH family; Region: DHH; pfam01368
324925006489	DHHA1 domain; Region: DHHA1; pfam02272
324925006490	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
324925006491	AMP binding site [chemical binding]; other site
324925006492	metal binding site [ion binding]; metal-binding site
324925006493	active site
324925006494	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
324925006495	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
324925006496	putative active site [active]
324925006497	metal binding site [ion binding]; metal-binding site
324925006498	homodimer binding site [polypeptide binding]; other site
324925006499	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
324925006500	Divergent AAA domain; Region: AAA_4; pfam04326
324925006501	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
324925006502	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
324925006503	PEP-CTERM motif; Region: VPEP; pfam07589
324925006504	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
324925006505	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
324925006506	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
324925006507	Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561
324925006508	NAD binding site [chemical binding]; other site
324925006509	homotetramer interface [polypeptide binding]; other site
324925006510	homodimer interface [polypeptide binding]; other site
324925006511	substrate binding site [chemical binding]; other site
324925006512	active site
324925006513	Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003
324925006514	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
324925006515	P loop; other site
324925006516	Nucleotide binding site [chemical binding]; other site
324925006517	DTAP/Switch II; other site
324925006518	Switch I; other site
324925006519	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
324925006520	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
324925006521	FMN binding site [chemical binding]; other site
324925006522	dimer interface [polypeptide binding]; other site
324925006523	Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528
324925006524	Flavoprotein; Region: Flavoprotein; cl08021
324925006525	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
324925006526	Part of AAA domain; Region: AAA_19; pfam13245
324925006527	Family description; Region: UvrD_C_2; pfam13538
324925006528	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_1; cd11347
324925006529	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
324925006530	active site
324925006531	catalytic site [active]
324925006532	Uncharacterized conserved protein [Function unknown]; Region: COG0432
324925006533	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
324925006534	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
324925006535	TPP-binding site; other site
324925006536	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
324925006537	PYR/PP interface [polypeptide binding]; other site
324925006538	dimer interface [polypeptide binding]; other site
324925006539	TPP binding site [chemical binding]; other site
324925006540	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
324925006541	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
324925006542	tetramer interfaces [polypeptide binding]; other site
324925006543	binuclear metal-binding site [ion binding]; other site
324925006544	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
324925006545	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
324925006546	MutS domain III; Region: MutS_III; pfam05192
324925006547	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
324925006548	Walker A/P-loop; other site
324925006549	ATP binding site [chemical binding]; other site
324925006550	Q-loop/lid; other site
324925006551	ABC transporter signature motif; other site
324925006552	Walker B; other site
324925006553	D-loop; other site
324925006554	H-loop/switch region; other site
324925006555	Smr domain; Region: Smr; pfam01713
324925006556	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
324925006557	RES domain; Region: RES; smart00953
324925006558	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
324925006559	non-specific DNA binding site [nucleotide binding]; other site
324925006560	salt bridge; other site
324925006561	sequence-specific DNA binding site [nucleotide binding]; other site
324925006562	HipA N-terminal domain; Region: Couple_hipA; pfam13657
324925006563	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
324925006564	HipA-like N-terminal domain; Region: HipA_N; pfam07805
324925006565	HipA-like C-terminal domain; Region: HipA_C; pfam07804
324925006566	Transposase [DNA replication, recombination, and repair]; Region: COG5421
324925006567	AAA domain; Region: AAA_21; pfam13304
324925006568	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
324925006569	ATP binding site [chemical binding]; other site
324925006570	Q-loop/lid; other site
324925006571	ABC transporter signature motif; other site
324925006572	Walker B; other site
324925006573	D-loop; other site
324925006574	H-loop/switch region; other site
324925006575	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
324925006576	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
324925006577	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
324925006578	S-adenosylmethionine binding site [chemical binding]; other site
324925006579	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
324925006580	DNA methylase; Region: N6_N4_Mtase; pfam01555
324925006581	DNA methylase; Region: N6_N4_Mtase; cl17433
324925006582	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
324925006583	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
324925006584	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
324925006585	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257
324925006586	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
324925006587	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
324925006588	non-specific DNA binding site [nucleotide binding]; other site
324925006589	salt bridge; other site
324925006590	sequence-specific DNA binding site [nucleotide binding]; other site
324925006591	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
324925006592	RES domain; Region: RES; smart00953
324925006593	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
324925006594	active site
324925006595	hydrophilic channel; other site
324925006596	dimerization interface [polypeptide binding]; other site
324925006597	catalytic residues [active]
324925006598	active site lid [active]
324925006599	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
324925006600	active site
324925006601	dimerization interface [polypeptide binding]; other site
324925006602	undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK12554
324925006603	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
324925006604	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
324925006605	active site
324925006606	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
324925006607	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
324925006608	Permease; Region: Permease; pfam02405
324925006609	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
324925006610	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
324925006611	Walker A/P-loop; other site
324925006612	ATP binding site [chemical binding]; other site
324925006613	Q-loop/lid; other site
324925006614	ABC transporter signature motif; other site
324925006615	Walker B; other site
324925006616	D-loop; other site
324925006617	H-loop/switch region; other site
324925006618	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
324925006619	mce related protein; Region: MCE; pfam02470
324925006620	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
324925006621	Beta-lactamase; Region: Beta-lactamase; pfam00144
324925006622	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
324925006623	Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467
324925006624	Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723
324925006625	iron-sulfur cluster [ion binding]; other site
324925006626	[2Fe-2S] cluster binding site [ion binding]; other site
324925006627	epoxyqueuosine reductase; Region: TIGR00276
324925006628	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
324925006629	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
324925006630	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
324925006631	P-loop; other site
324925006632	Magnesium ion binding site [ion binding]; other site
324925006633	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
324925006634	Magnesium ion binding site [ion binding]; other site
324925006635	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
324925006636	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
324925006637	purine monophosphate binding site [chemical binding]; other site
324925006638	dimer interface [polypeptide binding]; other site
324925006639	putative catalytic residues [active]
324925006640	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
324925006641	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
324925006642	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
324925006643	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
324925006644	Peptidase family M23; Region: Peptidase_M23; pfam01551
324925006645	Lumazine-binding domain; Region: Lumazine_bd; pfam12870
324925006646	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998
324925006647	N-acetyltransferase; Region: Acetyltransf_2; cl00949
324925006648	DinB superfamily; Region: DinB_2; pfam12867
324925006649	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
324925006650	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
324925006651	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
324925006652	Protein of unknown function (DUF497); Region: DUF497; pfam04365
324925006653	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
324925006654	non-specific DNA binding site [nucleotide binding]; other site
324925006655	salt bridge; other site
324925006656	sequence-specific DNA binding site [nucleotide binding]; other site
324925006657	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
324925006658	Domain of unknown function (DUF4325); Region: DUF4325; pfam14213
324925006659	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
324925006660	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
324925006661	active site
324925006662	substrate binding site [chemical binding]; other site
324925006663	cosubstrate binding site; other site
324925006664	catalytic site [active]
324925006665	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE, gammaproteobacterial type; Region: rSAM_QueE_gams; TIGR04349
324925006666	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
324925006667	FeS/SAM binding site; other site
324925006668	dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726
324925006669	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
324925006670	Ligand binding site; other site
324925006671	Putative Catalytic site; other site
324925006672	DXD motif; other site
324925006673	endonuclease IV; Provisional; Region: PRK01060
324925006674	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
324925006675	AP (apurinic/apyrimidinic) site pocket; other site
324925006676	DNA interaction; other site
324925006677	Metal-binding active site; metal-binding site
324925006678	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
324925006679	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
324925006680	Glutamine phosphoribosylpyrophosphate amidotransferase [Nucleotide transport and metabolism]; Region: PurF; COG0034
324925006681	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
324925006682	active site
324925006683	tetramer interface [polypeptide binding]; other site
324925006684	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
324925006685	active site
324925006686	DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734
324925006687	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039
324925006688	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
324925006689	active site
324925006690	HIGH motif; other site
324925006691	nucleotide binding site [chemical binding]; other site
324925006692	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
324925006693	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
324925006694	active site
324925006695	KMSKS motif; other site
324925006696	Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961
324925006697	tRNA binding surface [nucleotide binding]; other site
324925006698	anticodon binding site; other site
324925006699	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
324925006700	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
324925006701	Substrate binding site; other site
324925006702	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
324925006703	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
324925006704	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
324925006705	NAD binding site [chemical binding]; other site
324925006706	homodimer interface [polypeptide binding]; other site
324925006707	active site
324925006708	substrate binding site [chemical binding]; other site
324925006709	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
324925006710	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
324925006711	NAD binding site [chemical binding]; other site
324925006712	substrate binding site [chemical binding]; other site
324925006713	homodimer interface [polypeptide binding]; other site
324925006714	active site
324925006715	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
324925006716	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
324925006717	NADP binding site [chemical binding]; other site
324925006718	active site
324925006719	putative substrate binding site [chemical binding]; other site
324925006720	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
324925006721	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
324925006722	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
324925006723	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
324925006724	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
324925006725	substrate binding site; other site
324925006726	tetramer interface; other site
324925006727	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
324925006728	Sodium Bile acid symporter family; Region: SBF; cl17470
324925006729	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
324925006730	succinate CoA transferase; Region: YgfH_subfam; TIGR03458
324925006731	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
324925006732	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
324925006733	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
324925006734	active site
324925006735	SAM binding site [chemical binding]; other site
324925006736	homodimer interface [polypeptide binding]; other site
324925006737	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
324925006738	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
324925006739	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
324925006740	4Fe-4S binding domain; Region: Fer4; cl02805
324925006741	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
324925006742	Cysteine-rich domain; Region: CCG; pfam02754
324925006743	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959
324925006744	RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361
324925006745	DsrH like protein; Region: DsrH; pfam04077
324925006746	sulfur relay protein TusC/DsrF; Region: sulf_tusC_dsrF; TIGR03010
324925006747	DsrE/DsrF-like family; Region: DrsE; cl00672
324925006748	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
324925006749	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
324925006750	sulfite reductase, dissimilatory-type beta subunit; Region: dsrB; TIGR02066
324925006751	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
324925006752	sulfite reductase, dissimilatory-type alpha subunit; Region: dsrA; TIGR02064
324925006753	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
324925006754	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
324925006755	DsrC like protein; Region: DsrC; pfam04358
324925006756	Cobyrinic acid a,c-diamide synthase [Coenzyme metabolism]; Region: CobB; COG1797
324925006757	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
324925006758	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
324925006759	catalytic triad [active]
324925006760	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
324925006761	CPxP  motif; other site
324925006762	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
324925006763	active site residue [active]
324925006764	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
324925006765	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
324925006766	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
324925006767	active site residue [active]
324925006768	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
324925006769	Lipopolysaccharide-assembly; Region: LptE; cl01125
324925006770	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
324925006771	classical (c) SDRs; Region: SDR_c; cd05233
324925006772	NAD(P) binding site [chemical binding]; other site
324925006773	active site
324925006774	Ribulose bisphosphate carboxylase large chain; Region: RuBisCO_large; cl08232
324925006775	ribulose bisphosphate carboxylase, type III; Region: rubisco_III; TIGR03326
324925006776	dimer interface [polypeptide binding]; other site
324925006777	catalytic residue [active]
324925006778	metal binding site [ion binding]; metal-binding site
324925006779	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
324925006780	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
324925006781	putative active site; other site
324925006782	catalytic residue [active]
324925006783	short chain dehydrogenase; Validated; Region: PRK08324
324925006784	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007
324925006785	active site
324925006786	Zn2+ binding site [ion binding]; other site
324925006787	rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943
324925006788	putative NAD(P) binding site [chemical binding]; other site
324925006789	active site
324925006790	2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284
324925006791	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
324925006792	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
324925006793	putative active site [active]
324925006794	putative metal binding site [ion binding]; other site
324925006795	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
324925006796	SEFIR domain; Region: SEFIR; pfam08357
324925006797	Uncharacterized conserved protein [Function unknown]; Region: COG1262
324925006798	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
324925006799	Putative addiction module component; Region: Unstab_antitox; pfam09720
324925006800	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
324925006801	RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646
324925006802	putative active site [active]
324925006803	putative NTP binding site [chemical binding]; other site
324925006804	putative nucleic acid binding site [nucleotide binding]; other site
324925006805	HRDC domain; Region: HRDC; pfam00570
324925006806	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
324925006807	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
324925006808	putative active site [active]
324925006809	putative metal binding site [ion binding]; other site
324925006810	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
324925006811	AAA ATPase domain; Region: AAA_16; pfam13191
324925006812	NACHT domain; Region: NACHT; pfam05729
324925006813	Uncharacterized conserved protein [Function unknown]; Region: COG1262
324925006814	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
324925006815	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
324925006816	Bacillus subtilis YydB and related proteins, metallophosphatase domain; Region: MPP_YydB; cd07400
324925006817	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
324925006818	putative active site [active]
324925006819	putative metal binding site [ion binding]; other site
324925006820	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
324925006821	AAA ATPase domain; Region: AAA_16; pfam13191
324925006822	NACHT domain; Region: NACHT; pfam05729
324925006823	Uncharacterized conserved protein [Function unknown]; Region: COG1262
324925006824	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
324925006825	recombination regulator RecX; Reviewed; Region: recX; PRK00117
324925006826	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
324925006827	putative nucleotide binding site [chemical binding]; other site
324925006828	uridine monophosphate binding site [chemical binding]; other site
324925006829	homohexameric interface [polypeptide binding]; other site
324925006830	elongation factor Ts; Provisional; Region: tsf; PRK09377
324925006831	UBA/TS-N domain; Region: UBA; pfam00627
324925006832	Elongation factor TS; Region: EF_TS; pfam00889
324925006833	Elongation factor TS; Region: EF_TS; pfam00889
324925006834	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
324925006835	rRNA interaction site [nucleotide binding]; other site
324925006836	S8 interaction site; other site
324925006837	putative laminin-1 binding site; other site
324925006838	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
324925006839	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
324925006840	23S rRNA interface [nucleotide binding]; other site
324925006841	L3 interface [polypeptide binding]; other site
324925006842	GTP-binding protein Der; Reviewed; Region: PRK00093
324925006843	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
324925006844	G1 box; other site
324925006845	GTP/Mg2+ binding site [chemical binding]; other site
324925006846	Switch I region; other site
324925006847	G2 box; other site
324925006848	Switch II region; other site
324925006849	G3 box; other site
324925006850	G4 box; other site
324925006851	G5 box; other site
324925006852	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
324925006853	G1 box; other site
324925006854	GTP/Mg2+ binding site [chemical binding]; other site
324925006855	Switch I region; other site
324925006856	G2 box; other site
324925006857	G3 box; other site
324925006858	Switch II region; other site
324925006859	G4 box; other site
324925006860	G5 box; other site
324925006861	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
324925006862	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
324925006863	Walker A motif; other site
324925006864	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
324925006865	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
324925006866	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
324925006867	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
324925006868	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
324925006869	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
324925006870	Baculovirus E66 occlusion-derived virus envelope protein; Region: Baculo_E66; cl17813
324925006871	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
324925006872	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
324925006873	Repair protein; Region: Repair_PSII; cl01535
324925006874	Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512
324925006875	Repair protein; Region: Repair_PSII; pfam04536
324925006876	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
324925006877	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
324925006878	Zn2+ binding site [ion binding]; other site
324925006879	Mg2+ binding site [ion binding]; other site
324925006880	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
324925006881	synthetase active site [active]
324925006882	NTP binding site [chemical binding]; other site
324925006883	metal binding site [ion binding]; metal-binding site
324925006884	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
324925006885	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
324925006886	excinuclease ABC subunit B; Provisional; Region: PRK05298
324925006887	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
324925006888	ATP binding site [chemical binding]; other site
324925006889	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
324925006890	nucleotide binding region [chemical binding]; other site
324925006891	ATP-binding site [chemical binding]; other site
324925006892	Ultra-violet resistance protein B; Region: UvrB; pfam12344
324925006893	UvrB/uvrC motif; Region: UVR; pfam02151
324925006894	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
324925006895	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
324925006896	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
324925006897	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
324925006898	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
324925006899	Predicted permeases [General function prediction only]; Region: COG0795
324925006900	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
324925006901	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
324925006902	putative addiction module component, TIGR02574 family; Region: stabl_TIGR02574
324925006903	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
324925006904	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
324925006905	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
324925006906	Uncharacterized conserved protein [Function unknown]; Region: COG1262
324925006907	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
324925006908	Domain of unknown function (DUF4351); Region: DUF4351; pfam14261
324925006909	RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997
324925006910	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
324925006911	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
324925006912	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
324925006913	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
324925006914	DNA binding residues [nucleotide binding]
324925006915	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
324925006916	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
324925006917	active site
324925006918	HIGH motif; other site
324925006919	nucleotide binding site [chemical binding]; other site
324925006920	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
324925006921	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
324925006922	active site
324925006923	KMSKS motif; other site
324925006924	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
324925006925	tRNA binding surface [nucleotide binding]; other site
324925006926	anticodon binding site; other site
324925006927	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
324925006928	Clp protease; Region: CLP_protease; pfam00574
324925006929	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
324925006930	oligomer interface [polypeptide binding]; other site
324925006931	active site residues [active]
324925006932	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
324925006933	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
324925006934	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
324925006935	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
324925006936	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
324925006937	Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396
324925006938	nucleophile elbow; other site
324925006939	Surface antigen; Region: Bac_surface_Ag; pfam01103
324925006940	stationary phase survival protein SurE; Provisional; Region: PRK13932
324925006941	Uncharacterized protein conserved in bacteria (DUF2317); Region: DUF2317; pfam10079
324925006942	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4365
324925006943	Predicted transcriptional regulator [General function prediction only]; Region: COG2522
324925006944	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
324925006945	sequence-specific DNA binding site [nucleotide binding]; other site
324925006946	salt bridge; other site
324925006947	Haem-binding domain; Region: Haem_bd; pfam14376
324925006948	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
324925006949	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
324925006950	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
324925006951	glutamine binding [chemical binding]; other site
324925006952	catalytic triad [active]
324925006953	UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991
324925006954	Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562
324925006955	Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635
324925006956	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
324925006957	Protein of unknown function (DUF1016); Region: DUF1016; pfam06250
324925006958	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
324925006959	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
324925006960	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
324925006961	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
324925006962	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
324925006963	NAD(P) binding site [chemical binding]; other site
324925006964	catalytic residues [active]
324925006965	GTPase RsgA; Reviewed; Region: PRK00098
324925006966	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
324925006967	RNA binding site [nucleotide binding]; other site
324925006968	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
324925006969	GTPase/Zn-binding domain interface [polypeptide binding]; other site
324925006970	GTP/Mg2+ binding site [chemical binding]; other site
324925006971	G4 box; other site
324925006972	G5 box; other site
324925006973	G1 box; other site
324925006974	Switch I region; other site
324925006975	G2 box; other site
324925006976	G3 box; other site
324925006977	Switch II region; other site
324925006978	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
324925006979	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
324925006980	generic binding surface II; other site
324925006981	ssDNA binding site; other site
324925006982	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
324925006983	ATP binding site [chemical binding]; other site
324925006984	putative Mg++ binding site [ion binding]; other site
324925006985	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
324925006986	nucleotide binding region [chemical binding]; other site
324925006987	ATP-binding site [chemical binding]; other site
324925006988	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
324925006989	ribosome recycling factor; Reviewed; Region: frr; PRK00083
324925006990	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
324925006991	hinge region; other site
324925006992	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
324925006993	Transposase IS200 like; Region: Y1_Tnp; pfam01797
324925006994	Protein of unknown function (DUF497); Region: DUF497; pfam04365
324925006995	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304
324925006996	The nitrogenase enzyme system catalyzes the ATP-dependent reduction of dinitrogen to ammonia.  This group contains both alpha and beta subunits of component 1 of the three known genetically distinct types of nitrogenase systems: a molybdenum-dependent; Region: Oxidoreductase_nitrogenase; cl02775
324925006997	chlorophyllide reductase subunit Y; Region: BchY; TIGR02015
324925006998	Sporulation related domain; Region: SPOR; pfam05036
324925006999	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
324925007000	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
324925007001	generic binding surface II; other site
324925007002	generic binding surface I; other site
324925007003	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
324925007004	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
324925007005	Ligand binding site; other site
324925007006	oligomer interface; other site
324925007007	Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594
324925007008	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
324925007009	Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416
324925007010	Citrate synthase; Region: Citrate_synt; pfam00285
324925007011	oxalacetate binding site [chemical binding]; other site
324925007012	citrylCoA binding site [chemical binding]; other site
324925007013	coenzyme A binding site [chemical binding]; other site
324925007014	catalytic triad [active]
324925007015	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
324925007016	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
324925007017	ligand binding site [chemical binding]; other site
324925007018	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
324925007019	putative metal binding site [ion binding]; other site
324925007020	Uncharacterized conserved protein [Function unknown]; Region: COG1432
324925007021	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cd10146
324925007022	Copper chaperone [Inorganic ion transport and metabolism]; Region: CopZ; COG2608
324925007023	metal-binding site [ion binding]
324925007024	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925007025	binding surface
324925007026	Tetratricopeptide repeat; Region: TPR_16; pfam13432
324925007027	TPR motif; other site
324925007028	TPR repeat; Region: TPR_11; pfam13414
324925007029	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
324925007030	chorismate binding enzyme; Region: Chorismate_bind; cl10555
324925007031	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
324925007032	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
324925007033	dimer interface [polypeptide binding]; other site
324925007034	tetramer interface [polypeptide binding]; other site
324925007035	PYR/PP interface [polypeptide binding]; other site
324925007036	TPP binding site [chemical binding]; other site
324925007037	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
324925007038	TPP-binding site; other site
324925007039	Transposase IS200 like; Region: Y1_Tnp; cl00848
324925007040	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
324925007041	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
324925007042	NACHT domain; Region: NACHT; pfam05729
324925007043	Walker A/P-loop; other site
324925007044	ATP binding site [chemical binding]; other site
324925007045	Q-loop/lid; other site
324925007046	Uncharacterized conserved protein [Function unknown]; Region: COG1262
324925007047	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
324925007048	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
324925007049	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
324925007050	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
324925007051	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
324925007052	P-loop; other site
324925007053	Magnesium ion binding site [ion binding]; other site
324925007054	Restriction endonuclease; Region: Mrr_cat; pfam04471
324925007055	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
324925007056	Walker A motif; other site
324925007057	ATP binding site [chemical binding]; other site
324925007058	Walker B motif; other site
324925007059	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
324925007060	putative Zn2+ binding site [ion binding]; other site
324925007061	putative DNA binding site [nucleotide binding]; other site
324925007062	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Region: menH_SHCHC; TIGR03695
324925007063	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
324925007064	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
324925007065	Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378
324925007066	substrate binding site [chemical binding]; other site
324925007067	oxyanion hole (OAH) forming residues; other site
324925007068	trimer interface [polypeptide binding]; other site
324925007069	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
324925007070	o-succinylbenzoate synthase; Region: menC_gamma/gm+; TIGR01927
324925007071	active site
324925007072	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
324925007073	O-succinylbenzoate-CoA ligase; Region: menE; TIGR01923
324925007074	acyl-activating enzyme (AAE) consensus motif; other site
324925007075	putative AMP binding site [chemical binding]; other site
324925007076	putative active site [active]
324925007077	putative CoA binding site [chemical binding]; other site
324925007078	dihydrodipicolinate reductase; Provisional; Region: PRK00048
324925007079	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
324925007080	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
324925007081	ParB-like nuclease domain; Region: ParB; smart00470
324925007082	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
324925007083	KorB domain; Region: KorB; pfam08535
324925007084	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
324925007085	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
324925007086	P-loop; other site
324925007087	Magnesium ion binding site [ion binding]; other site
324925007088	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
324925007089	Magnesium ion binding site [ion binding]; other site
324925007090	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
324925007091	MgtE intracellular N domain; Region: MgtE_N; smart00924
324925007092	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
324925007093	Divalent cation transporter; Region: MgtE; pfam01769
324925007094	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
324925007095	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
324925007096	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
324925007097	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
324925007098	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
324925007099	NADH(P)-binding; Region: NAD_binding_10; pfam13460
324925007100	NAD(P) binding site [chemical binding]; other site
324925007101	putative active site [active]
324925007102	Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093
324925007103	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
324925007104	non-specific DNA binding site [nucleotide binding]; other site
324925007105	salt bridge; other site
324925007106	sequence-specific DNA binding site [nucleotide binding]; other site
324925007107	CRISPR associated protein Cas6; Region: Cas_Cas6; pfam01881
324925007108	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cl11817
324925007109	CRISPR/Cas system-associated RAMP superfamily protein Csm5; Region: Csm5_III-A; cl17437
324925007110	CRISPR/Cas system-associated RAMP superfamily protein Csm4; Region: Csm4_III-A; cl17438
324925007111	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
324925007112	CRISPR/Cas system-associated protein Csm2; Region: Csm2_III-A; cd09647
324925007113	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09680
324925007114	CRISPR/Cas system-associated protein Csx15; Region: Csx15_I-U; cd09766
324925007115	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
324925007116	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
324925007117	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
324925007118	putative active site [active]
324925007119	putative NTP binding site [chemical binding]; other site
324925007120	putative nucleic acid binding site [nucleotide binding]; other site
324925007121	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634
324925007122	Fic family protein [Function unknown]; Region: COG3177
324925007123	Fic/DOC family; Region: Fic; pfam02661
324925007124	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
324925007125	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
324925007126	Ligand Binding Site [chemical binding]; other site
324925007127	putative hydrolase; Provisional; Region: PRK11460
324925007128	Predicted esterase [General function prediction only]; Region: COG0400
324925007129	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
324925007130	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
324925007131	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
324925007132	substrate binding pocket [chemical binding]; other site
324925007133	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
324925007134	B12 binding site [chemical binding]; other site
324925007135	cobalt ligand [ion binding]; other site
324925007136	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
324925007137	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
324925007138	Domain of unknown function (DUF4412); Region: DUF4412; pfam14371
324925007139	F5/8 type C domain; Region: F5_F8_type_C; pfam00754
324925007140	Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_2; cd07819
324925007141	putative hydrophobic ligand binding site [chemical binding]; other site
324925007142	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
324925007143	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
324925007144	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
324925007145	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
324925007146	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
324925007147	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
324925007148	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
324925007149	NlpC/P60 family; Region: NLPC_P60; pfam00877
324925007150	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
324925007151	CapA and related proteins, metallophosphatase domain; Region: MPP_CapA; cd07381
324925007152	putative active site [active]
324925007153	putative metal binding site [ion binding]; other site
324925007154	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
324925007155	SGNH_peri1; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri1; cd01825
324925007156	active site
324925007157	oxyanion hole [active]
324925007158	catalytic triad [active]
324925007159	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
324925007160	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
324925007161	SGNH_peri1; putative periplasmic member of the SGNH-family of hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known...; Region: SGNH_hydrolase_peri1; cd01825
324925007162	active site
324925007163	oxyanion hole [active]
324925007164	catalytic triad [active]
324925007165	Uncharacterized conserved protein (DUF2278); Region: DUF2278; pfam10042
324925007166	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
324925007167	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
324925007168	putative active site [active]
324925007169	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
324925007170	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
324925007171	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
324925007172	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
324925007173	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK12490
324925007174	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
324925007175	This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814
324925007176	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
324925007177	putative deacylase active site [active]
324925007178	Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637
324925007179	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
324925007180	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
324925007181	nucleophile elbow; other site
324925007182	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
324925007183	ALDH subfamily: Coniferyl aldehyde dehydrogenase, ALDH families 3, 13, and 14, and other related proteins; Region: ALDH_F3-13-14_CALDH-like; cd07087
324925007184	NAD(P) binding site [chemical binding]; other site
324925007185	catalytic residues [active]
324925007186	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
324925007187	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
324925007188	Ligand Binding Site [chemical binding]; other site
324925007189	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
324925007190	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
324925007191	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
324925007192	Methyltransferase domain; Region: Methyltransf_24; pfam13578
324925007193	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
324925007194	Peptidase family U32; Region: Peptidase_U32; pfam01136
324925007195	anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055
324925007196	cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345
324925007197	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
324925007198	FAD binding pocket [chemical binding]; other site
324925007199	FAD binding motif [chemical binding]; other site
324925007200	phosphate binding motif [ion binding]; other site
324925007201	beta-alpha-beta structure motif; other site
324925007202	NAD binding pocket [chemical binding]; other site
324925007203	Iron coordination center [ion binding]; other site
324925007204	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
324925007205	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
324925007206	Coenzyme F420-reducing hydrogenase, alpha subunit [Energy production and conversion]; Region: FrhA; COG3259
324925007207	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
324925007208	DNA-damage-inducible protein J [DNA replication, recombination, and repair]; Region: RelB; COG3077
324925007209	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041; cl17396
324925007210	Plasmid pRiA4b ORF-3-like protein; Region: PRiA4_ORF3; pfam07929
324925007211	Predicted ATPase [General function prediction only]; Region: COG4637
324925007212	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
324925007213	Walker A/P-loop; other site
324925007214	ATP binding site [chemical binding]; other site
324925007215	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
324925007216	ABC transporter signature motif; other site
324925007217	Walker B; other site
324925007218	D-loop; other site
324925007219	H-loop/switch region; other site
324925007220	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
324925007221	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304
324925007222	Domain of unknown function (DUF4415); Region: DUF4415; pfam14384
324925007223	Protein of unknown function (DUF497); Region: DUF497; pfam04365
324925007224	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
324925007225	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
324925007226	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
324925007227	non-specific DNA binding site [nucleotide binding]; other site
324925007228	salt bridge; other site
324925007229	sequence-specific DNA binding site [nucleotide binding]; other site
324925007230	PEGA domain; Region: PEGA; pfam08308
324925007231	Transposase DDE domain group 1; Region: DDE_Tnp_1_4; pfam13701
324925007232	four helix bundle suffix domain; Region: 4helix_suffix; TIGR04258
324925007233	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
324925007234	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
324925007235	DNA-binding site [nucleotide binding]; DNA binding site
324925007236	RNA-binding motif; other site
324925007237	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
324925007238	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
324925007239	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
324925007240	Mechanosensitive ion channel; Region: MS_channel; pfam00924
324925007241	Protoporphyrinogen oxidase [Coenzyme metabolism]; Region: HemY; COG1232
324925007242	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
324925007243	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
324925007244	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
324925007245	trimer interface [polypeptide binding]; other site
324925007246	putative metal binding site [ion binding]; other site
324925007247	Bacteriochlorophyll C binding protein; Region: Bac_chlorC; pfam02043
324925007248	Winged helix-turn helix; Region: HTH_29; pfam13551
324925007249	Winged helix-turn helix; Region: HTH_33; pfam13592
324925007250	DDE superfamily endonuclease; Region: DDE_3; pfam13358
324925007251	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
324925007252	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
324925007253	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
324925007254	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
324925007255	Walker A/P-loop; other site
324925007256	ATP binding site [chemical binding]; other site
324925007257	Q-loop/lid; other site
324925007258	ABC transporter signature motif; other site
324925007259	Walker B; other site
324925007260	D-loop; other site
324925007261	H-loop/switch region; other site
324925007262	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
324925007263	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
324925007264	Zn2+ binding site [ion binding]; other site
324925007265	Mg2+ binding site [ion binding]; other site
324925007266	YtxH-like protein; Region: YtxH; pfam12732
324925007267	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
324925007268	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
324925007269	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
324925007270	hinge; other site
324925007271	active site
324925007272	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
324925007273	cystathionine beta-synthase; Region: cysta_beta; TIGR01137
324925007274	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
324925007275	dimer interface [polypeptide binding]; other site
324925007276	pyridoxal 5'-phosphate binding site [chemical binding]; other site
324925007277	catalytic residue [active]
324925007278	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the pyridoxal-phosphate (PALP) dependent enzyme domain upstream.   The vitamin B6 complex comprises pyridoxine, pyridoxal, and pyridoxamine, as well...; Region: CBS_pair_PALP_assoc2; cd04609
324925007279	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
324925007280	alanine racemase; Reviewed; Region: alr; PRK00053
324925007281	active site
324925007282	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
324925007283	dimer interface [polypeptide binding]; other site
324925007284	substrate binding site [chemical binding]; other site
324925007285	catalytic residues [active]
324925007286	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
324925007287	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
324925007288	AAA ATPase domain; Region: AAA_16; pfam13191
324925007289	Archaeal ATPase; Region: Arch_ATPase; pfam01637
324925007290	Walker A motif; other site
324925007291	ATP binding site [chemical binding]; other site
324925007292	Walker B motif; other site
324925007293	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
324925007294	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
324925007295	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
324925007296	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
324925007297	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
324925007298	FMN binding site [chemical binding]; other site
324925007299	active site
324925007300	catalytic residues [active]
324925007301	substrate binding site [chemical binding]; other site
324925007302	recombinase A; Provisional; Region: recA; PRK09354
324925007303	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
324925007304	hexamer interface [polypeptide binding]; other site
324925007305	Walker A motif; other site
324925007306	ATP binding site [chemical binding]; other site
324925007307	Walker B motif; other site
324925007308	uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228
324925007309	hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466
324925007310	putative NADP binding site [chemical binding]; other site
324925007311	putative substrate binding site [chemical binding]; other site
324925007312	active site
324925007313	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
324925007314	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
324925007315	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
324925007316	trigger factor; Region: tig; TIGR00115
324925007317	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
324925007318	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK14663
324925007319	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
324925007320	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
324925007321	dimerization interface [polypeptide binding]; other site
324925007322	active site
324925007323	YopX protein; Region: YopX; cl09859
324925007324	Dihydroneopterin aldolase; Region: FolB; pfam02152
324925007325	active site
324925007326	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
324925007327	catalytic center binding site [active]
324925007328	ATP binding site [chemical binding]; other site
324925007329	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
324925007330	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
324925007331	P loop; other site
324925007332	Nucleotide binding site [chemical binding]; other site
324925007333	DTAP/Switch II; other site
324925007334	Switch I; other site
324925007335	Bacteriochlorophyll C binding protein; Region: Bac_chlorC; pfam02043
324925007336	Chlorosome envelope protein C; Region: Chlorosome_CsmC; pfam11098
324925007337	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
324925007338	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
324925007339	P loop; other site
324925007340	Nucleotide binding site [chemical binding]; other site
324925007341	DTAP/Switch II; other site
324925007342	Switch I; other site
324925007343	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
324925007344	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
324925007345	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
324925007346	FAD binding pocket [chemical binding]; other site
324925007347	FAD binding motif [chemical binding]; other site
324925007348	phosphate binding motif [ion binding]; other site
324925007349	beta-alpha-beta structure motif; other site
324925007350	NAD binding pocket [chemical binding]; other site
324925007351	Iron coordination center [ion binding]; other site
324925007352	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
324925007353	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
324925007354	dimer interface [polypeptide binding]; other site
324925007355	ssDNA binding site [nucleotide binding]; other site
324925007356	tetramer (dimer of dimers) interface [polypeptide binding]; other site
324925007357	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
324925007358	DNA polymerase III, delta subunit; Region: holA; TIGR01128
324925007359	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
324925007360	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
324925007361	NAD(P) binding site [chemical binding]; other site
324925007362	active site
324925007363	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
324925007364	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
324925007365	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
324925007366	catalytic residue [active]
324925007367	Cna protein B-type domain; Region: Cna_B_2; pfam13715
324925007368	Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629
324925007369	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
324925007370	N-terminal plug; other site
324925007371	ligand-binding site [chemical binding]; other site
324925007372	magnesium chelatase, H subunit; Region: BchH; TIGR02025
324925007373	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
324925007374	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
324925007375	magnesium chelatase subunit H; Provisional; Region: PRK12493
324925007376	Domain of unknown function (DUF3479); Region: DUF3479; pfam11965
324925007377	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
324925007378	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
324925007379	Mg-protoporphyrin IX methyl transferase; Validated; Region: PRK07580
324925007380	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
324925007381	S-adenosylmethionine binding site [chemical binding]; other site
324925007382	Magnesium-protoporphyrin IX methyltransferase C-terminus; Region: Mg-por_mtran_C; pfam07109
324925007383	magnesium-protoporphyrin IX monomethyl ester anaerobic oxidative cyclase; Region: BchE; TIGR02026
324925007384	B12 binding domain_like associated with radical SAM domain. This domain shows similarity with B12 (adenosylcobamide) binding domains found in several enzymes, such as glutamate mutase, methionine synthase and methylmalonyl-CoA mutase, but it lacks the...; Region: radical_SAM_B12_BD; cd02068
324925007385	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
324925007386	FeS/SAM binding site; other site
324925007387	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
324925007388	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
324925007389	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
324925007390	Predicted acyltransferases [Lipid metabolism]; Region: COG1835
324925007391	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
324925007392	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
324925007393	putative ADP-binding pocket [chemical binding]; other site
324925007394	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4627
324925007395	Methyltransferase domain; Region: Methyltransf_23; pfam13489
324925007396	Transposase [DNA replication, recombination, and repair]; Region: COG5421
324925007397	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
324925007398	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
324925007399	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
324925007400	NAD(P) binding site [chemical binding]; other site
324925007401	active site
324925007402	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
324925007403	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
324925007404	Methyltransferase domain; Region: Methyltransf_24; pfam13578
324925007405	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
324925007406	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
324925007407	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
324925007408	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
324925007409	active site
324925007410	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
324925007411	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
324925007412	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
324925007413	putative acyl-acceptor binding pocket; other site
324925007414	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
324925007415	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
324925007416	active site
324925007417	HIGH motif; other site
324925007418	nucleotide binding site [chemical binding]; other site
324925007419	Family of unknown function (DUF490); Region: DUF490; pfam04357
324925007420	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
324925007421	Flavoprotein; Region: Flavoprotein; pfam02441
324925007422	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
324925007423	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
324925007424	Fe-S cluster binding site [ion binding]; other site
324925007425	active site
324925007426	replicative DNA helicase; Region: DnaB; TIGR00665
324925007427	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
324925007428	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
324925007429	Walker A motif; other site
324925007430	ATP binding site [chemical binding]; other site
324925007431	Walker B motif; other site
324925007432	DNA binding loops [nucleotide binding]
324925007433	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
324925007434	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
324925007435	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
324925007436	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
324925007437	SurA N-terminal domain; Region: SurA_N_3; cl07813
324925007438	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
324925007439	PPIC-type PPIASE domain; Region: Rotamase_3; pfam13616
324925007440	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
324925007441	Methyltransferase domain; Region: Methyltransf_18; pfam12847
324925007442	S-adenosylmethionine binding site [chemical binding]; other site
324925007443	GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441
324925007444	GIY-YIG motif/motif A; other site
324925007445	putative active site [active]
324925007446	putative metal binding site [ion binding]; other site
324925007447	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
324925007448	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
324925007449	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
324925007450	thiamine monophosphate kinase; Provisional; Region: PRK05731
324925007451	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
324925007452	ATP binding site [chemical binding]; other site
324925007453	dimerization interface [polypeptide binding]; other site
324925007454	Predicted ATPase [General function prediction only]; Region: COG4637
324925007455	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
324925007456	Walker A/P-loop; other site
324925007457	ATP binding site [chemical binding]; other site
324925007458	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
324925007459	Q-loop/lid; other site
324925007460	ABC transporter signature motif; other site
324925007461	Walker B; other site
324925007462	D-loop; other site
324925007463	H-loop/switch region; other site
324925007464	Domain of unknown function (DUF4276); Region: DUF4276; pfam14103
324925007465	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
324925007466	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
324925007467	pyridoxal 5'-phosphate binding site [chemical binding]; other site
324925007468	catalytic residue [active]
324925007469	Fic family protein [Function unknown]; Region: COG3177
324925007470	Fic/DOC family; Region: Fic; pfam02661
324925007471	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
324925007472	Clp amino terminal domain; Region: Clp_N; pfam02861
324925007473	Clp amino terminal domain; Region: Clp_N; pfam02861
324925007474	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
324925007475	Walker A motif; other site
324925007476	ATP binding site [chemical binding]; other site
324925007477	Walker B motif; other site
324925007478	arginine finger; other site
324925007479	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
324925007480	Walker A motif; other site
324925007481	ATP binding site [chemical binding]; other site
324925007482	Walker B motif; other site
324925007483	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
324925007484	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
324925007485	metal binding site 2 [ion binding]; metal-binding site
324925007486	putative DNA binding helix; other site
324925007487	metal binding site 1 [ion binding]; metal-binding site
324925007488	dimer interface [polypeptide binding]; other site
324925007489	structural Zn2+ binding site [ion binding]; other site
324925007490	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495
324925007491	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
324925007492	FeS/SAM binding site; other site
324925007493	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08270
324925007494	ATP cone domain; Region: ATP-cone; pfam03477
324925007495	Class III ribonucleotide reductase; Region: RNR_III; cd01675
324925007496	effector binding site; other site
324925007497	active site
324925007498	Zn binding site [ion binding]; other site
324925007499	glycine loop; other site
324925007500	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
324925007501	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
324925007502	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
324925007503	putative NAD(P) binding site [chemical binding]; other site
324925007504	Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375
324925007505	glycerol kinase; Provisional; Region: glpK; PRK00047
324925007506	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
324925007507	N- and C-terminal domain interface [polypeptide binding]; other site
324925007508	active site
324925007509	MgATP binding site [chemical binding]; other site
324925007510	catalytic site [active]
324925007511	metal binding site [ion binding]; metal-binding site
324925007512	glycerol binding site [chemical binding]; other site
324925007513	homotetramer interface [polypeptide binding]; other site
324925007514	homodimer interface [polypeptide binding]; other site
324925007515	FBP binding site [chemical binding]; other site
324925007516	protein IIAGlc interface [polypeptide binding]; other site
324925007517	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
324925007518	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
324925007519	sequence-specific DNA binding site [nucleotide binding]; other site
324925007520	salt bridge; other site
324925007521	Domain of unknown function (DUF955); Region: DUF955; cl01076
324925007522	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
324925007523	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
324925007524	putative active site [active]
324925007525	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
324925007526	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
324925007527	Walker A/P-loop; other site
324925007528	ATP binding site [chemical binding]; other site
324925007529	Q-loop/lid; other site
324925007530	ABC transporter signature motif; other site
324925007531	Walker B; other site
324925007532	D-loop; other site
324925007533	H-loop/switch region; other site
324925007534	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
324925007535	Putative addiction module component; Region: Unstab_antitox; pfam09720
324925007536	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483
324925007537	Putative addiction module component; Region: Unstab_antitox; pfam09720
324925007538	cysteinyl-tRNA synthetase; Provisional; Region: cysS; PRK14535
324925007539	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
324925007540	AAA domain; Region: AAA_21; pfam13304
324925007541	Walker A/P-loop; other site
324925007542	ATP binding site [chemical binding]; other site
324925007543	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
324925007544	ABC transporter signature motif; other site
324925007545	Walker B; other site
324925007546	D-loop; other site
324925007547	H-loop/switch region; other site
324925007548	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
324925007549	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
324925007550	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
324925007551	FeS/SAM binding site; other site
324925007552	C-3',4' desaturase CrtD; Region: desat_CrtD; TIGR02733
324925007553	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
324925007554	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
324925007555	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
324925007556	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
324925007557	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
324925007558	Transglycosylase; Region: Transgly; pfam00912
324925007559	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
324925007560	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
324925007561	GMP synthase; Reviewed; Region: guaA; PRK00074
324925007562	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
324925007563	AMP/PPi binding site [chemical binding]; other site
324925007564	candidate oxyanion hole; other site
324925007565	catalytic triad [active]
324925007566	potential glutamine specificity residues [chemical binding]; other site
324925007567	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
324925007568	ATP Binding subdomain [chemical binding]; other site
324925007569	Ligand Binding sites [chemical binding]; other site
324925007570	Dimerization subdomain; other site
324925007571	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
324925007572	active site residue [active]
324925007573	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
324925007574	salt bridge; other site
324925007575	non-specific DNA binding site [nucleotide binding]; other site
324925007576	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
324925007577	sequence-specific DNA binding site [nucleotide binding]; other site
324925007578	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402
324925007579	putative active site [active]
324925007580	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
324925007581	Protein of unknown function (DUF2442); Region: DUF2442; pfam10387
324925007582	Domain of unknown function (DUF4160); Region: DUF4160; pfam13711
324925007583	Putative phosphatase regulatory subunit; Region: CBM_21; pfam03370
324925007584	CT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_1; cd04870
324925007585	ACT domains found N-terminal of phosphoserine phosphatase (PSP, SerB); Region: ACT_PSP_2; cd04871
324925007586	phosphoserine phosphatase SerB; Region: serB; TIGR00338
324925007587	Acid Phosphatase; Region: Acid_PPase; cl17256
324925007588	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
324925007589	motif II; other site
324925007590	Ferredoxin [Energy production and conversion]; Region: COG1146
324925007591	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
324925007592	Ferredoxin [Energy production and conversion]; Region: COG1146
324925007593	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
324925007594	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
324925007595	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
324925007596	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
324925007597	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
324925007598	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
324925007599	motif 1; other site
324925007600	active site
324925007601	motif 2; other site
324925007602	motif 3; other site
324925007603	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
324925007604	DHHA1 domain; Region: DHHA1; pfam02272
324925007605	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
324925007606	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
324925007607	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
324925007608	dimer interface [polypeptide binding]; other site
324925007609	PYR/PP interface [polypeptide binding]; other site
324925007610	TPP binding site [chemical binding]; other site
324925007611	substrate binding site [chemical binding]; other site
324925007612	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867
324925007613	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
324925007614	TPP-binding site [chemical binding]; other site
324925007615	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
324925007616	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
324925007617	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
324925007618	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
324925007619	IHF - DNA interface [nucleotide binding]; other site
324925007620	IHF dimer interface [polypeptide binding]; other site
324925007621	elongation factor P; Validated; Region: PRK00529
324925007622	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
324925007623	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
324925007624	RNA binding site [nucleotide binding]; other site
324925007625	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
324925007626	RNA binding site [nucleotide binding]; other site
324925007627	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
324925007628	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
324925007629	carboxyltransferase (CT) interaction site; other site
324925007630	biotinylation site [posttranslational modification]; other site
324925007631	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
324925007632	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
324925007633	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
324925007634	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
324925007635	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
324925007636	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
324925007637	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
324925007638	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
324925007639	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
324925007640	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
324925007641	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
324925007642	Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168
324925007643	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
324925007644	DNA binding site [nucleotide binding]
324925007645	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
324925007646	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
324925007647	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
324925007648	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
324925007649	RPB11 interaction site [polypeptide binding]; other site
324925007650	RPB12 interaction site [polypeptide binding]; other site
324925007651	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
324925007652	RPB12 interaction site [polypeptide binding]; other site
324925007653	RPB3 interaction site [polypeptide binding]; other site
324925007654	RPB1 interaction site [polypeptide binding]; other site
324925007655	RPB11 interaction site [polypeptide binding]; other site
324925007656	RPB10 interaction site [polypeptide binding]; other site
324925007657	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
324925007658	core dimer interface [polypeptide binding]; other site
324925007659	peripheral dimer interface [polypeptide binding]; other site
324925007660	L10 interface [polypeptide binding]; other site
324925007661	L11 interface [polypeptide binding]; other site
324925007662	putative EF-Tu interaction site [polypeptide binding]; other site
324925007663	putative EF-G interaction site [polypeptide binding]; other site
324925007664	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
324925007665	23S rRNA interface [nucleotide binding]; other site
324925007666	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
324925007667	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
324925007668	mRNA/rRNA interface [nucleotide binding]; other site
324925007669	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
324925007670	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
324925007671	23S rRNA interface [nucleotide binding]; other site
324925007672	L7/L12 interface [polypeptide binding]; other site
324925007673	putative thiostrepton binding site; other site
324925007674	L25 interface [polypeptide binding]; other site
324925007675	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
324925007676	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
324925007677	putative homodimer interface [polypeptide binding]; other site
324925007678	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
324925007679	heterodimer interface [polypeptide binding]; other site
324925007680	homodimer interface [polypeptide binding]; other site
324925007681	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
324925007682	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
324925007683	classical (c) SDRs; Region: SDR_c; cd05233
324925007684	NAD(P) binding site [chemical binding]; other site
324925007685	active site
324925007686	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Provisional; Region: PRK02048
324925007687	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
324925007688	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
324925007689	Septum formation initiator; Region: DivIC; cl17659
324925007690	enolase; Provisional; Region: eno; PRK00077
324925007691	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
324925007692	dimer interface [polypeptide binding]; other site
324925007693	metal binding site [ion binding]; metal-binding site
324925007694	substrate binding pocket [chemical binding]; other site
324925007695	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
324925007696	elongation factor G; Reviewed; Region: PRK12740
324925007697	G1 box; other site
324925007698	putative GEF interaction site [polypeptide binding]; other site
324925007699	GTP/Mg2+ binding site [chemical binding]; other site
324925007700	Switch I region; other site
324925007701	G2 box; other site
324925007702	G3 box; other site
324925007703	Switch II region; other site
324925007704	G4 box; other site
324925007705	G5 box; other site
324925007706	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
324925007707	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
324925007708	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
324925007709	DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442
324925007710	Ligand binding site; other site
324925007711	Putative Catalytic site; other site
324925007712	DXD motif; other site
324925007713	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
324925007714	Photosystem I psaA/psaB protein; Region: PsaA_PsaB; cl08224
324925007715	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
324925007716	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
324925007717	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
324925007718	Domain of unknown function (DUF202); Region: DUF202; pfam02656
324925007719	Rubredoxin [Energy production and conversion]; Region: COG1773
324925007720	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
324925007721	iron binding site [ion binding]; other site
324925007722	Transglycosylase; Region: Transgly; cl17702
324925007723	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
324925007724	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
324925007725	ATP binding site [chemical binding]; other site
324925007726	Mg2+ binding site [ion binding]; other site
324925007727	G-X-G motif; other site
324925007728	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
324925007729	ATP binding site [chemical binding]; other site
324925007730	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
324925007731	competence damage-inducible protein A; Provisional; Region: PRK00549
324925007732	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
324925007733	putative MPT binding site; other site
324925007734	Competence-damaged protein; Region: CinA; pfam02464
324925007735	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
324925007736	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
324925007737	putative catalytic residues [active]
324925007738	putative nucleotide binding site [chemical binding]; other site
324925007739	putative aspartate binding site [chemical binding]; other site
324925007740	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
324925007741	dimer interface [polypeptide binding]; other site
324925007742	putative threonine allosteric regulatory site; other site
324925007743	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
324925007744	putative threonine allosteric regulatory site; other site
324925007745	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
324925007746	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
324925007747	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
324925007748	core domain interface [polypeptide binding]; other site
324925007749	delta subunit interface [polypeptide binding]; other site
324925007750	epsilon subunit interface [polypeptide binding]; other site
324925007751	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
324925007752	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
324925007753	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
324925007754	beta subunit interaction interface [polypeptide binding]; other site
324925007755	Walker A motif; other site
324925007756	ATP binding site [chemical binding]; other site
324925007757	Walker B motif; other site
324925007758	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
324925007759	homoserine kinase; Provisional; Region: PRK01212
324925007760	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
324925007761	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
324925007762	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
324925007763	pyridoxal 5'-phosphate binding site [chemical binding]; other site
324925007764	catalytic residue [active]
324925007765	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
324925007766	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
324925007767	putative acyl-acceptor binding pocket; other site
324925007768	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
324925007769	homopentamer interface [polypeptide binding]; other site
324925007770	active site
324925007771	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
324925007772	dimer interface [polypeptide binding]; other site
324925007773	active site
324925007774	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
324925007775	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
324925007776	non-specific DNA binding site [nucleotide binding]; other site
324925007777	salt bridge; other site
324925007778	sequence-specific DNA binding site [nucleotide binding]; other site
324925007779	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
324925007780	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
324925007781	substrate binding site [chemical binding]; other site
324925007782	active site
324925007783	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
324925007784	Cysteine-rich domain; Region: CCG; pfam02754
324925007785	Cysteine-rich domain; Region: CCG; pfam02754
324925007786	Succinate dehydrogenase/fumarate reductase, Fe-S protein subunit [Energy production and conversion]; Region: FrdB; COG0479
324925007787	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
324925007788	catalytic loop [active]
324925007789	iron binding site [ion binding]; other site
324925007790	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
324925007791	L-aspartate oxidase; Provisional; Region: PRK06175
324925007792	succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup; Region: sdhA_frdA_Gneg; TIGR01812
324925007793	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
324925007794	FOG: CBS domain [General function prediction only]; Region: COG0517
324925007795	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630
324925007796	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
324925007797	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
324925007798	Protein export membrane protein; Region: SecD_SecF; cl14618
324925007799	Bacterial ABC transporter protein EcsB; Region: EcsB; cl11542
324925007800	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
324925007801	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
324925007802	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
324925007803	putative homodimer interface [polypeptide binding]; other site
324925007804	putative homotetramer interface [polypeptide binding]; other site
324925007805	putative allosteric switch controlling residues; other site
324925007806	putative metal binding site [ion binding]; other site
324925007807	putative homodimer-homodimer interface [polypeptide binding]; other site
324925007808	Protein of unknown function (DUF1997); Region: DUF1997; pfam09366
324925007809	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
324925007810	Helix-turn-helix domain; Region: HTH_28; pfam13518
324925007811	HTH-like domain; Region: HTH_21; pfam13276
324925007812	insertion element IS2 transposase InsD; Provisional; Region: PRK14702
324925007813	Integrase core domain; Region: rve; pfam00665
324925007814	Integrase core domain; Region: rve_3; pfam13683
324925007815	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
324925007816	B12 binding site [chemical binding]; other site
324925007817	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
324925007818	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
324925007819	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
324925007820	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
324925007821	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
324925007822	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
324925007823	classical (c) SDRs; Region: SDR_c; cd05233
324925007824	NAD(P) binding site [chemical binding]; other site
324925007825	active site
324925007826	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
324925007827	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
324925007828	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
324925007829	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
324925007830	putative active site; other site
324925007831	catalytic residue [active]
324925007832	short chain dehydrogenase; Validated; Region: PRK08324
324925007833	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
324925007834	active site
324925007835	Zn2+ binding site [ion binding]; other site
324925007836	intersubunit interface [polypeptide binding]; other site
324925007837	rhamnulose-1-phosphate aldolase/alcohol dehydrogenase, classical (c) SDRs; Region: R1PA_ADH_SDR_c; cd08943
324925007838	putative NAD(P) binding site [chemical binding]; other site
324925007839	active site
324925007840	Rifin/stevor family; Region: Rifin_STEVOR; cl14106
324925007841	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
324925007842	2-vinyl bacteriochlorophyllide hydratase (BCHF); Region: BCHF; pfam07284
324925007843	C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716
324925007844	O-methyltransferase; Region: Methyltransf_2; pfam00891
324925007845	Flavodoxin domain; Region: Flavodoxin_5; cl17428
324925007846	Proto-chlorophyllide reductase 57 kD subunit; Region: PCP_red; pfam08369
324925007847	Anion-transporting ATPase; Region: ArsA_ATPase; pfam02374
324925007848	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
324925007849	P loop; other site
324925007850	Nucleotide binding site [chemical binding]; other site
324925007851	DTAP/Switch II; other site
324925007852	Switch I; other site
324925007853	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
324925007854	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
324925007855	B12 binding site [chemical binding]; other site
324925007856	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
324925007857	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
324925007858	FeS/SAM binding site; other site
324925007859	C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716
324925007860	O-methyltransferase; Region: Methyltransf_2; pfam00891
324925007861	Phosphotransferase enzyme family; Region: APH; pfam01636
324925007862	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
324925007863	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
324925007864	glucose-1-phosphate adenylyltransferase; Region: glgC; TIGR02091
324925007865	Substrate binding site; other site
324925007866	metal-binding site
324925007867	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
324925007868	putative trimer interface [polypeptide binding]; other site
324925007869	putative CoA binding site [chemical binding]; other site
324925007870	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
324925007871	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u1; cd11493
324925007872	Na binding site [ion binding]; other site
324925007873	Protein of unknown function (DUF2576); Region: DUF2576; pfam10845
324925007874	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
324925007875	PAS fold; Region: PAS_3; pfam08447
324925007876	putative active site [active]
324925007877	heme pocket [chemical binding]; other site
324925007878	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
324925007879	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
324925007880	GAF domain; Region: GAF_2; pfam13185
324925007881	GAF domain; Region: GAF; pfam01590
324925007882	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
324925007883	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
324925007884	putative active site [active]
324925007885	heme pocket [chemical binding]; other site
324925007886	nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938
324925007887	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
324925007888	putative active site [active]
324925007889	heme pocket [chemical binding]; other site
324925007890	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
324925007891	putative active site [active]
324925007892	heme pocket [chemical binding]; other site
324925007893	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
324925007894	dimer interface [polypeptide binding]; other site
324925007895	phosphorylation site [posttranslational modification]
324925007896	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
324925007897	ATP binding site [chemical binding]; other site
324925007898	Mg2+ binding site [ion binding]; other site
324925007899	G-X-G motif; other site
324925007900	Response regulator receiver domain; Region: Response_reg; pfam00072
324925007901	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
324925007902	active site
324925007903	phosphorylation site [posttranslational modification]
324925007904	intermolecular recognition site; other site
324925007905	dimerization interface [polypeptide binding]; other site
324925007906	Response regulator receiver domain; Region: Response_reg; pfam00072
324925007907	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
324925007908	active site
324925007909	phosphorylation site [posttranslational modification]
324925007910	intermolecular recognition site; other site
324925007911	dimerization interface [polypeptide binding]; other site
324925007912	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
324925007913	NADH(P)-binding; Region: NAD_binding_10; pfam13460
324925007914	NAD(P) binding site [chemical binding]; other site
324925007915	putative active site [active]
324925007916	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
324925007917	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
324925007918	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
324925007919	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
324925007920	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
324925007921	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
324925007922	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
324925007923	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
324925007924	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
324925007925	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
324925007926	putative active site [active]
324925007927	heme pocket [chemical binding]; other site
324925007928	integral membrane protein, YkoY family; Region: R_switched_YkoY; TIGR03716
324925007929	K+ transporter [Inorganic ion transport and metabolism]; Region: Kup; COG3158
324925007930	potassium uptake protein; Region: kup; TIGR00794
324925007931	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
324925007932	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
324925007933	thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293
324925007934	Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412
324925007935	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
324925007936	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
324925007937	DsbD alpha interface [polypeptide binding]; other site
324925007938	catalytic residues [active]
324925007939	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
324925007940	ResB-like family; Region: ResB; pfam05140
324925007941	Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504
324925007942	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
324925007943	oligomeric interface; other site
324925007944	putative active site [active]
324925007945	homodimer interface [polypeptide binding]; other site
324925007946	Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456
324925007947	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
324925007948	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
324925007949	trmE is a tRNA modification GTPase; Region: trmE; cd04164
324925007950	G1 box; other site
324925007951	GTP/Mg2+ binding site [chemical binding]; other site
324925007952	Switch I region; other site
324925007953	G2 box; other site
324925007954	Switch II region; other site
324925007955	G3 box; other site
324925007956	G4 box; other site
324925007957	G5 box; other site
324925007958	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
324925007959	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
324925007960	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
324925007961	homodimer interface [polypeptide binding]; other site
324925007962	metal binding site [ion binding]; metal-binding site
324925007963	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
324925007964	homodimer interface [polypeptide binding]; other site
324925007965	active site
324925007966	putative chemical substrate binding site [chemical binding]; other site
324925007967	Predicted esterase [General function prediction only]; Region: COG0400
324925007968	trehalose synthase; Region: treS_nterm; TIGR02456
324925007969	Alpha amylase catalytic domain found in Trehalose synthetase; Region: AmyAc_TreS; cd11334
324925007970	active site
324925007971	catalytic site [active]
324925007972	trehalose synthase-fused probable maltokinase; Region: TreS_Cterm; TIGR02457
324925007973	Uncharacterized protein, probably involved in trehalose biosynthesis [Carbohydrate transport and metabolism]; Region: Ble; COG3281
324925007974	Domain of unknown function (DUF3416); Region: DUF3416; pfam11896
324925007975	Alpha amylase catalytic domain found in GlgE-like proteins; Region: AmyAc_GlgE_like; cd11344
324925007976	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
324925007977	active site
324925007978	homodimer interface [polypeptide binding]; other site
324925007979	catalytic site [active]
324925007980	acceptor binding site [chemical binding]; other site
324925007981	peptide chain release factor 2; Validated; Region: prfB; PRK00578
324925007982	PCRF domain; Region: PCRF; pfam03462
324925007983	RF-1 domain; Region: RF-1; pfam00472
324925007984	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
324925007985	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
324925007986	active site
324925007987	metal binding site [ion binding]; metal-binding site
324925007988	DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864
324925007989	DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892
324925007990	active site
324925007991	substrate binding site [chemical binding]; other site
324925007992	Mg2+ binding site [ion binding]; other site
324925007993	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
324925007994	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
324925007995	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
324925007996	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
324925007997	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
324925007998	catalytic residue [active]
324925007999	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
324925008000	Domain of unknown function (DUF4411); Region: DUF4411; pfam14367
324925008001	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
324925008002	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
324925008003	sequence-specific DNA binding site [nucleotide binding]; other site
324925008004	salt bridge; other site
324925008005	Domain of unknown function (DUF955); Region: DUF955; cl01076
324925008006	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
324925008007	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
324925008008	homodimer interface [polypeptide binding]; other site
324925008009	active site
324925008010	OstA-like protein; Region: OstA_2; pfam13100
324925008011	putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605
324925008012	Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecO; COG1381
324925008013	Recombination protein O N terminal; Region: RecO_N; pfam11967
324925008014	Recombination protein O C terminal; Region: RecO_C; pfam02565
324925008015	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
324925008016	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
324925008017	inhibitor-cofactor binding pocket; inhibition site
324925008018	pyridoxal 5'-phosphate binding site [chemical binding]; other site
324925008019	catalytic residue [active]
324925008020	Uncharacterized ACR, COG1993; Region: DUF190; cl00872
324925008021	camphor resistance protein CrcB; Provisional; Region: PRK14202
324925008022	SOUL heme-binding protein; Region: SOUL; pfam04832
324925008023	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
324925008024	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
324925008025	active site
324925008026	prephenate dehydrogenase; Validated; Region: PRK08507
324925008027	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
324925008028	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
324925008029	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03708
324925008030	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
324925008031	active site
324925008032	motif I; other site
324925008033	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
324925008034	motif II; other site
324925008035	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
324925008036	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
324925008037	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
324925008038	Walker A motif; other site
324925008039	ATP binding site [chemical binding]; other site
324925008040	Walker B motif; other site
324925008041	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
324925008042	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
324925008043	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
324925008044	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
324925008045	catalytic core [active]
324925008046	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
324925008047	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
324925008048	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
324925008049	membrane protein; Provisional; Region: PRK14410
324925008050	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
324925008051	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
324925008052	dimerization interface [polypeptide binding]; other site
324925008053	putative ATP binding site [chemical binding]; other site
324925008054	aspartate kinase III; Validated; Region: PRK09084
324925008055	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
324925008056	nucleotide binding site [chemical binding]; other site
324925008057	substrate binding site [chemical binding]; other site
324925008058	ACT domains located C-terminal to the catalytic domain of  the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912
324925008059	dimer interface [polypeptide binding]; other site
324925008060	allosteric regulatory binding pocket; other site
324925008061	ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892
324925008062	NlpC/P60 family; Region: NLPC_P60; pfam00877
324925008063	ribosomal protein L11 methyltransferase; Reviewed; Region: prmA; PRK00517
324925008064	Methyltransferase domain; Region: Methyltransf_18; pfam12847
324925008065	exopolyphosphatase; Region: exo_poly_only; TIGR03706
324925008066	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
324925008067	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
324925008068	S-adenosylmethionine binding site [chemical binding]; other site
324925008069	Protein of unknown function (DUF2971); Region: DUF2971; pfam11185
324925008070	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
324925008071	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
324925008072	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
324925008073	AAA domain; Region: AAA_14; pfam13173
324925008074	Domain of unknown function (DUF4143); Region: DUF4143; pfam13635
324925008075	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
324925008076	AAA domain; Region: AAA_23; pfam13476
324925008077	AAA domain; Region: AAA_21; pfam13304
324925008078	Walker A/P-loop; other site
324925008079	ATP binding site [chemical binding]; other site
324925008080	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
324925008081	Walker B; other site
324925008082	D-loop; other site
324925008083	H-loop/switch region; other site
324925008084	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
324925008085	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
324925008086	acyl-activating enzyme (AAE) consensus motif; other site
324925008087	putative AMP binding site [chemical binding]; other site
324925008088	putative active site [active]
324925008089	putative CoA binding site [chemical binding]; other site
324925008090	adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986
324925008091	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
324925008092	inhibitor-cofactor binding pocket; inhibition site
324925008093	pyridoxal 5'-phosphate binding site [chemical binding]; other site
324925008094	catalytic residue [active]
324925008095	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
324925008096	AAA domain; Region: AAA_26; pfam13500
324925008097	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
324925008098	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
324925008099	S-adenosylmethionine binding site [chemical binding]; other site
324925008100	Protein of unknown function (DUF452); Region: DUF452; cl01062
324925008101	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
324925008102	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
324925008103	substrate-cofactor binding pocket; other site
324925008104	pyridoxal 5'-phosphate binding site [chemical binding]; other site
324925008105	catalytic residue [active]
324925008106	biotin synthase; Region: bioB; TIGR00433
324925008107	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
324925008108	FeS/SAM binding site; other site
324925008109	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
324925008110	Biotin operon repressor [Transcription]; Region: BirA; COG1654
324925008111	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
324925008112	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
324925008113	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
324925008114	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
324925008115	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
324925008116	active site
324925008117	metal binding site [ion binding]; metal-binding site
324925008118	DNA topoisomerase I; Validated; Region: PRK06599
324925008119	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
324925008120	active site
324925008121	interdomain interaction site; other site
324925008122	putative metal-binding site [ion binding]; other site
324925008123	nucleotide binding site [chemical binding]; other site
324925008124	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
324925008125	domain I; other site
324925008126	DNA binding groove [nucleotide binding]
324925008127	phosphate binding site [ion binding]; other site
324925008128	domain II; other site
324925008129	domain III; other site
324925008130	nucleotide binding site [chemical binding]; other site
324925008131	catalytic site [active]
324925008132	domain IV; other site
324925008133	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
324925008134	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
324925008135	Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551
324925008136	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
324925008137	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
324925008138	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
324925008139	G1 box; other site
324925008140	GTP/Mg2+ binding site [chemical binding]; other site
324925008141	Switch I region; other site
324925008142	G2 box; other site
324925008143	G3 box; other site
324925008144	Switch II region; other site
324925008145	G4 box; other site
324925008146	G5 box; other site
324925008147	Nucleoside recognition; Region: Gate; pfam07670
324925008148	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
324925008149	Nucleoside recognition; Region: Gate; pfam07670
324925008150	Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918
324925008151	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
324925008152	nucleotide binding site/active site [active]
324925008153	HIT family signature motif; other site
324925008154	catalytic residue [active]
324925008155	Domain of unknown function DUF21; Region: DUF21; pfam01595
324925008156	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
324925008157	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
324925008158	Transporter associated domain; Region: CorC_HlyC; smart01091
324925008159	TPR repeat; Region: TPR_11; pfam13414
324925008160	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925008161	binding surface
324925008162	TPR motif; other site
324925008163	TPR repeat; Region: TPR_11; pfam13414
324925008164	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
324925008165	TonB-dependent copper receptor; Region: TonB-copper; TIGR01778
324925008166	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Validated; Region: PRK07570
324925008167	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
324925008168	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK07573
324925008169	L-aspartate oxidase; Provisional; Region: PRK06175
324925008170	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
324925008171	succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046
324925008172	Succinate:quinone oxidoreductase (SQR)-like Type B subfamily 2, transmembrane subunit; composed of proteins with similarity to the SQRs of Geobacter metallireducens and Corynebacterium glutamicum. SQR catalyzes the oxidation of succinate to fumarate...; Region: SQR_TypeB_2_TM; cd03498
324925008173	putative Iron-sulfur protein interface [polypeptide binding]; other site
324925008174	proximal heme binding site [chemical binding]; other site
324925008175	distal heme binding site [chemical binding]; other site
324925008176	putative dimer interface [polypeptide binding]; other site
324925008177	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
324925008178	Esterase/lipase [General function prediction only]; Region: COG1647
324925008179	Serine hydrolase; Region: Ser_hydrolase; cl17834
324925008180	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
324925008181	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
324925008182	Protein of unknown function DUF89; Region: DUF89; cl15397
324925008183	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
324925008184	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
324925008185	arsenical-resistance protein; Region: acr3; TIGR00832
324925008186	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
324925008187	active site residue [active]
324925008188	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
324925008189	Low molecular weight phosphatase family; Region: LMWPc; cd00115
324925008190	active site
324925008191	PhoU domain; Region: PhoU; pfam01895
324925008192	PhoU domain; Region: PhoU; pfam01895
324925008193	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
324925008194	putative active site [active]
324925008195	CAAX protease self-immunity; Region: Abi; pfam02517
324925008196	C-5 cytosine-specific DNA methylase; Region: DNA_methylase; pfam00145
324925008197	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
324925008198	cofactor binding site; other site
324925008199	DNA binding site [nucleotide binding]
324925008200	substrate interaction site [chemical binding]; other site
324925008201	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
324925008202	Catalytic GIY-YIG domain of type II restriction enzyme R.Eco29kI, R.NgoMIII, and similar proteins; Region: GIY-YIG_RE_Eco29kI_NgoMIII; cd10452
324925008203	homodimer interface [polypeptide binding]; other site
324925008204	GIY-YIG motif/motif A; other site
324925008205	active site
324925008206	DNA binding site [nucleotide binding]
324925008207	putative metal binding site [ion binding]; other site
324925008208	SEFIR domain; Region: SEFIR; pfam08357
324925008209	AAA domain; Region: AAA_22; pfam13401
324925008210	TPR repeat; Region: TPR_11; pfam13414
324925008211	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925008212	TPR motif; other site
324925008213	binding surface
324925008214	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925008215	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925008216	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
324925008217	TPR motif; other site
324925008218	binding surface
324925008219	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
324925008220	active site
324925008221	intersubunit interactions; other site
324925008222	catalytic residue [active]
324925008223	deoxyhypusine synthase-like protein; Provisional; Region: PRK02492
324925008224	deoxyhypusine synthase; Region: dhys; TIGR00321
324925008225	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
324925008226	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
324925008227	active site
324925008228	HIGH motif; other site
324925008229	dimer interface [polypeptide binding]; other site
324925008230	KMSKS motif; other site
324925008231	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
324925008232	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
324925008233	motif II; other site
324925008234	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
324925008235	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
324925008236	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
324925008237	active site
324925008238	HIGH motif; other site
324925008239	KMSK motif region; other site
324925008240	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
324925008241	tRNA binding surface [nucleotide binding]; other site
324925008242	anticodon binding site; other site
324925008243	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
324925008244	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
324925008245	active site
324925008246	(T/H)XGH motif; other site
324925008247	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
324925008248	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
324925008249	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
324925008250	F0F1 ATP synthase subunit B; Provisional; Region: PRK14472
324925008251	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
324925008252	ATP synthase subunit C; Region: ATP-synt_C; cl00466
324925008253	F0F1 ATP synthase subunit A; Provisional; Region: PRK13419
324925008254	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
324925008255	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
324925008256	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
324925008257	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
324925008258	butyryl-CoA:acetate CoA-transferase; Region: butyr_acet_CoA; TIGR03948
324925008259	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
324925008260	cell division protein FtsZ; Validated; Region: PRK09330
324925008261	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
324925008262	nucleotide binding site [chemical binding]; other site
324925008263	SulA interaction site; other site
324925008264	cell division protein FtsA; Region: ftsA; TIGR01174
324925008265	Cell division protein FtsA; Region: FtsA; smart00842
324925008266	Cell division protein FtsA; Region: FtsA; pfam14450
324925008267	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
324925008268	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
324925008269	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
324925008270	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
324925008271	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
324925008272	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
324925008273	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
324925008274	active site
324925008275	homodimer interface [polypeptide binding]; other site
324925008276	cell division protein FtsW; Region: ftsW; TIGR02614
324925008277	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK02472
324925008278	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
324925008279	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
324925008280	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
324925008281	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
324925008282	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
324925008283	Mg++ binding site [ion binding]; other site
324925008284	putative catalytic motif [active]
324925008285	putative substrate binding site [chemical binding]; other site
324925008286	putative bifunctional UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase/UDP-N-acetylmuramoyl-tripeptide:D-alanyl-D-alanine ligase; Provisional; Region: PRK11929
324925008287	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
324925008288	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
324925008289	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
324925008290	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
324925008291	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
324925008292	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
324925008293	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
324925008294	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
324925008295	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
324925008296	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
324925008297	Acylphosphatase; Region: Acylphosphatase; cl00551
324925008298	MraW methylase family; Region: Methyltransf_5; cl17771
324925008299	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
324925008300	cell division protein MraZ; Reviewed; Region: PRK00326
324925008301	MraZ protein; Region: MraZ; pfam02381
324925008302	MraZ protein; Region: MraZ; pfam02381
324925008303	YacP-like NYN domain; Region: NYN_YacP; pfam05991
324925008304	Chorismate mutase type II; Region: CM_2; smart00830
324925008305	YceG-like family; Region: YceG; pfam02618
324925008306	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
324925008307	dimerization interface [polypeptide binding]; other site
324925008308	Phosphoglycerate kinase; Region: PGK; pfam00162
324925008309	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
324925008310	substrate binding site [chemical binding]; other site
324925008311	hinge regions; other site
324925008312	ADP binding site [chemical binding]; other site
324925008313	catalytic site [active]
324925008314	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
324925008315	Uncharacterized conserved protein [Function unknown]; Region: COG3339
324925008316	TRAM domain; Region: TRAM; pfam01938
324925008317	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
324925008318	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
324925008319	S-adenosylmethionine binding site [chemical binding]; other site
324925008320	N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178
324925008321	PLD-like domain; Region: PLDc_2; pfam13091
324925008322	putative homodimer interface [polypeptide binding]; other site
324925008323	putative active site [active]
324925008324	catalytic site [active]
324925008325	DEAD-like helicases superfamily; Region: DEXDc; smart00487
324925008326	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
324925008327	ATP binding site [chemical binding]; other site
324925008328	putative Mg++ binding site [ion binding]; other site
324925008329	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
324925008330	nucleotide binding region [chemical binding]; other site
324925008331	ATP-binding site [chemical binding]; other site
324925008332	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
324925008333	TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950
324925008334	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
324925008335	AAA domain; Region: AAA_23; pfam13476
324925008336	Walker A/P-loop; other site
324925008337	ATP binding site [chemical binding]; other site
324925008338	Q-loop/lid; other site
324925008339	PemK-like protein; Region: PemK; pfam02452
324925008340	TIR domain; Region: TIR_2; pfam13676
324925008341	CHAT domain; Region: CHAT; pfam12770
324925008342	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925008343	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925008344	TPR motif; other site
324925008345	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925008346	binding surface
324925008347	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925008348	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925008349	binding surface
324925008350	TPR motif; other site
324925008351	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925008352	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925008353	binding surface
324925008354	TPR motif; other site
324925008355	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925008356	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925008357	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925008358	binding surface
324925008359	TPR motif; other site
324925008360	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925008361	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925008362	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925008363	binding surface
324925008364	TPR motif; other site
324925008365	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925008366	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
324925008367	binding surface
324925008368	TPR motif; other site
324925008369	Tetratricopeptide repeat; Region: TPR_12; pfam13424
324925008370	peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903
324925008371	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
324925008372	active site
324925008373	fructokinase; Reviewed; Region: PRK09557
324925008374	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
324925008375	nucleotide binding site [chemical binding]; other site
324925008376	PAP2_like_4 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_4; cd03395
324925008377	active site
324925008378	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
324925008379	membrane protein insertase; Provisional; Region: PRK01318
324925008380	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
324925008381	Haemolytic domain; Region: Haemolytic; pfam01809
324925008382	ribonuclease P; Reviewed; Region: rnpA; PRK01903
324925008383	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399