-- dump date   	20140619_233148
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
370438000001	chromosomal replication initiation protein; Reviewed; Region: dnaA; PRK00149
370438000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
370438000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438000004	Walker A motif; other site
370438000005	ATP binding site [chemical binding]; other site
370438000006	Walker B motif; other site
370438000007	arginine finger; other site
370438000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
370438000009	DnaA box-binding interface [nucleotide binding]; other site
370438000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
370438000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
370438000012	putative DNA binding surface [nucleotide binding]; other site
370438000013	dimer interface [polypeptide binding]; other site
370438000014	beta-clamp/clamp loader binding surface; other site
370438000015	beta-clamp/translesion DNA polymerase binding surface; other site
370438000016	recombination protein F; Reviewed; Region: recF; PRK00064
370438000017	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
370438000018	Walker A/P-loop; other site
370438000019	ATP binding site [chemical binding]; other site
370438000020	Q-loop/lid; other site
370438000021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
370438000022	ABC transporter signature motif; other site
370438000023	Walker B; other site
370438000024	D-loop; other site
370438000025	H-loop/switch region; other site
370438000026	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
370438000027	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
370438000028	Mg2+ binding site [ion binding]; other site
370438000029	G-X-G motif; other site
370438000030	Fe-S metabolism associated domain; Region: SufE; cl00951
370438000031	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
370438000032	anchoring element; other site
370438000033	dimer interface [polypeptide binding]; other site
370438000034	ATP binding site [chemical binding]; other site
370438000035	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
370438000036	active site
370438000037	putative metal-binding site [ion binding]; other site
370438000038	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
370438000039	CHASE3 domain; Region: CHASE3; cl05000
370438000040	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
370438000041	dimerization interface [polypeptide binding]; other site
370438000042	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
370438000043	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
370438000044	dimer interface [polypeptide binding]; other site
370438000045	putative CheW interface [polypeptide binding]; other site
370438000046	DNA gyrase subunit A; Validated; Region: PRK05560
370438000047	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
370438000048	CAP-like domain; other site
370438000049	active site
370438000050	primary dimer interface [polypeptide binding]; other site
370438000051	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
370438000052	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
370438000053	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
370438000054	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
370438000055	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
370438000056	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
370438000057	pyridoxal 5'-phosphate synthase, synthase subunit Pdx1; Region: TIGR00343
370438000058	PdxS is a subunit of the pyridoxal 5'-phosphate (PLP) synthase, an important enzyme in deoxyxylulose 5-phosphate (DXP)-independent pathway for de novo biosynthesis of PLP,  present in some eubacteria, in archaea, fungi, plants, plasmodia, and some...; Region: pdxS; cd04727
370438000059	active site
370438000060	multimer interface [polypeptide binding]; other site
370438000061	Glutamine Amidotransferase (GATase_I) involved in pyridoxine biosynthesis; Region: GATase1_PB; cd01749
370438000062	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13181
370438000063	predicted active site [active]
370438000064	catalytic triad [active]
370438000065	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
370438000066	homodimer interface [polypeptide binding]; other site
370438000067	pyridoxal 5'-phosphate binding site [chemical binding]; other site
370438000068	catalytic residue [active]
370438000069	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
370438000070	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
370438000071	ligand binding site [chemical binding]; other site
370438000072	NAD binding site [chemical binding]; other site
370438000073	dimerization interface [polypeptide binding]; other site
370438000074	catalytic site [active]
370438000075	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
370438000076	putative L-serine binding site [chemical binding]; other site
370438000077	seryl-tRNA synthetase; Provisional; Region: PRK05431
370438000078	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
370438000079	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
370438000080	dimer interface [polypeptide binding]; other site
370438000081	active site
370438000082	motif 1; other site
370438000083	motif 2; other site
370438000084	motif 3; other site
370438000085	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
370438000086	active site
370438000087	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
370438000088	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
370438000089	FAD binding site [chemical binding]; other site
370438000090	homotetramer interface [polypeptide binding]; other site
370438000091	substrate binding pocket [chemical binding]; other site
370438000092	catalytic base [active]
370438000093	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
370438000094	Ligand binding site [chemical binding]; other site
370438000095	Electron transfer flavoprotein domain; Region: ETF; pfam01012
370438000096	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
370438000097	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
370438000098	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
370438000099	oxidoreductase; Provisional; Region: PRK10015
370438000100	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
370438000101	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
370438000102	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
370438000103	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
370438000104	MarR family; Region: MarR; pfam01047
370438000105	Transcription factor zinc-finger; Region: zf-TFIIB; cl01565
370438000106	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
370438000107	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
370438000108	active site
370438000109	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
370438000110	active site
370438000111	NTP binding site [chemical binding]; other site
370438000112	metal binding triad [ion binding]; metal-binding site
370438000113	antibiotic binding site [chemical binding]; other site
370438000114	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
370438000115	nucleoside/Zn binding site; other site
370438000116	dimer interface [polypeptide binding]; other site
370438000117	catalytic motif [active]
370438000118	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
370438000119	dimer interface [polypeptide binding]; other site
370438000120	[2Fe-2S] cluster binding site [ion binding]; other site
370438000121	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
370438000122	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
370438000123	Putative Fe-S cluster; Region: FeS; cl17515
370438000124	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
370438000125	PAS domain; Region: PAS_9; pfam13426
370438000126	putative active site [active]
370438000127	heme pocket [chemical binding]; other site
370438000128	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
370438000129	Transcriptional regulator [Transcription]; Region: IclR; COG1414
370438000130	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
370438000131	Bacterial transcriptional regulator; Region: IclR; pfam01614
370438000132	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
370438000133	Predicted amidohydrolase [General function prediction only]; Region: COG0388
370438000134	active site
370438000135	catalytic triad [active]
370438000136	dimer interface [polypeptide binding]; other site
370438000137	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
370438000138	Plasmid stabilisation system protein; Region: Plasmid_stabil; cl17483
370438000139	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
370438000140	YwpF-like protein; Region: YwpF; pfam14183
370438000141	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
370438000142	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370438000143	active site
370438000144	phosphorylation site [posttranslational modification]
370438000145	intermolecular recognition site; other site
370438000146	dimerization interface [polypeptide binding]; other site
370438000147	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
370438000148	DNA binding site [nucleotide binding]
370438000149	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
370438000150	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
370438000151	dimerization interface [polypeptide binding]; other site
370438000152	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
370438000153	dimer interface [polypeptide binding]; other site
370438000154	phosphorylation site [posttranslational modification]
370438000155	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
370438000156	ATP binding site [chemical binding]; other site
370438000157	Mg2+ binding site [ion binding]; other site
370438000158	G-X-G motif; other site
370438000159	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
370438000160	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
370438000161	E3 interaction surface; other site
370438000162	HlyD family secretion protein; Region: HlyD_3; pfam13437
370438000163	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
370438000164	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
370438000165	Walker A/P-loop; other site
370438000166	ATP binding site [chemical binding]; other site
370438000167	Q-loop/lid; other site
370438000168	ABC transporter signature motif; other site
370438000169	Walker B; other site
370438000170	D-loop; other site
370438000171	H-loop/switch region; other site
370438000172	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
370438000173	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
370438000174	FtsX-like permease family; Region: FtsX; pfam02687
370438000175	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
370438000176	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
370438000177	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231
370438000178	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
370438000179	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
370438000180	active site
370438000181	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
370438000182	Predicted integral membrane protein [Function unknown]; Region: COG5542
370438000183	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
370438000184	metal binding site 2 [ion binding]; metal-binding site
370438000185	putative DNA binding helix; other site
370438000186	metal binding site 1 [ion binding]; metal-binding site
370438000187	dimer interface [polypeptide binding]; other site
370438000188	structural Zn2+ binding site [ion binding]; other site
370438000189	Rubredoxin [Energy production and conversion]; Region: COG1773
370438000190	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
370438000191	iron binding site [ion binding]; other site
370438000192	Rubrerythrin [Energy production and conversion]; Region: COG1592
370438000193	rubrerythrin-like, diiron-binding domain; Region: Rubrerythrin_like; cd01046
370438000194	diiron binding motif [ion binding]; other site
370438000195	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
370438000196	dimer interface [polypeptide binding]; other site
370438000197	phosphorylation site [posttranslational modification]
370438000198	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
370438000199	ATP binding site [chemical binding]; other site
370438000200	Mg2+ binding site [ion binding]; other site
370438000201	G-X-G motif; other site
370438000202	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
370438000203	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370438000204	active site
370438000205	phosphorylation site [posttranslational modification]
370438000206	intermolecular recognition site; other site
370438000207	dimerization interface [polypeptide binding]; other site
370438000208	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
370438000209	DNA binding site [nucleotide binding]
370438000210	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
370438000211	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
370438000212	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
370438000213	glutamate dehydrogenase; Provisional; Region: PRK09414
370438000214	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
370438000215	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
370438000216	NAD(P) binding site [chemical binding]; other site
370438000217	DNA polymerase III subunits gamma and tau; Validated; Region: PRK05563
370438000218	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438000219	Walker B motif; other site
370438000220	arginine finger; other site
370438000221	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
370438000222	hypothetical protein; Validated; Region: PRK00153
370438000223	recombination protein RecR; Reviewed; Region: recR; PRK00076
370438000224	Helix-hairpin-helix DNA-binding motif class 1; Region: HhH1; smart00278
370438000225	RecR protein; Region: RecR; pfam02132
370438000226	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
370438000227	putative active site [active]
370438000228	putative metal-binding site [ion binding]; other site
370438000229	tetramer interface [polypeptide binding]; other site
370438000230	SigmaK-factor processing regulatory protein BofA; Region: BofA; pfam07441
370438000231	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
370438000232	2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659
370438000233	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
370438000234	dimer interface [polypeptide binding]; other site
370438000235	PYR/PP interface [polypeptide binding]; other site
370438000236	TPP binding site [chemical binding]; other site
370438000237	substrate binding site [chemical binding]; other site
370438000238	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
370438000239	TPP-binding site [chemical binding]; other site
370438000240	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
370438000241	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
370438000242	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
370438000243	Inhibitor of sigma-G Gin; Region: Gin; pfam10764
370438000244	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
370438000245	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
370438000246	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
370438000247	catalytic residue [active]
370438000248	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
370438000249	thymidylate kinase; Validated; Region: tmk; PRK00698
370438000250	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
370438000251	TMP-binding site; other site
370438000252	ATP-binding site [chemical binding]; other site
370438000253	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
370438000254	DNA polymerase III subunit delta'; Validated; Region: PRK08485
370438000255	Uncharacterized homolog of PSP1 [Function unknown]; Region: COG1774
370438000256	Protein of unknown function (DUF972); Region: DUF972; pfam06156
370438000257	Predicted methyltransferases [General function prediction only]; Region: COG0313
370438000258	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
370438000259	putative SAM binding site [chemical binding]; other site
370438000260	putative homodimer interface [polypeptide binding]; other site
370438000261	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
370438000262	methionyl-tRNA synthetase; Reviewed; Region: PRK11893
370438000263	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
370438000264	active site
370438000265	HIGH motif; other site
370438000266	KMSKS motif; other site
370438000267	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
370438000268	tRNA binding surface [nucleotide binding]; other site
370438000269	anticodon binding site; other site
370438000270	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
370438000271	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
370438000272	active site
370438000273	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
370438000274	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
370438000275	homodimer interface [polypeptide binding]; other site
370438000276	Walker A motif; other site
370438000277	ATP binding site [chemical binding]; other site
370438000278	hydroxycobalamin binding site [chemical binding]; other site
370438000279	Walker B motif; other site
370438000280	Uncharacterized protein family (UPF0158); Region: UPF0158; pfam03682
370438000281	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
370438000282	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
370438000283	Walker A/P-loop; other site
370438000284	ATP binding site [chemical binding]; other site
370438000285	Q-loop/lid; other site
370438000286	ABC transporter signature motif; other site
370438000287	Walker B; other site
370438000288	D-loop; other site
370438000289	H-loop/switch region; other site
370438000290	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
370438000291	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
370438000292	Walker A/P-loop; other site
370438000293	ATP binding site [chemical binding]; other site
370438000294	Q-loop/lid; other site
370438000295	ABC transporter signature motif; other site
370438000296	Walker B; other site
370438000297	D-loop; other site
370438000298	H-loop/switch region; other site
370438000299	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
370438000300	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
370438000301	TM-ABC transporter signature motif; other site
370438000302	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
370438000303	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
370438000304	TM-ABC transporter signature motif; other site
370438000305	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
370438000306	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
370438000307	putative ligand binding site [chemical binding]; other site
370438000308	Domain of unknown function (DUF348); Region: DUF348; pfam03990
370438000309	Domain of unknown function (DUF348); Region: DUF348; pfam03990
370438000310	G5 domain; Region: G5; pfam07501
370438000311	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3584
370438000312	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
370438000313	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
370438000314	Protein of unknown function (DUF458); Region: DUF458; pfam04308
370438000315	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
370438000316	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
370438000317	active site
370438000318	YabG peptidase U57; Region: Peptidase_U57; pfam05582
370438000319	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
370438000320	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
370438000321	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
370438000322	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
370438000323	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
370438000324	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
370438000325	Domain of unknown function (DUF3794); Region: DUF3794; pfam12673
370438000326	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
370438000327	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; pfam02575
370438000328	Protein of unknown function, DUF606; Region: DUF606; pfam04657
370438000329	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437
370438000330	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
370438000331	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
370438000332	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
370438000333	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
370438000334	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00128
370438000335	Transcriptional regulators [Transcription]; Region: GntR; COG1802
370438000336	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
370438000337	DNA-binding site [nucleotide binding]; DNA binding site
370438000338	FCD domain; Region: FCD; pfam07729
370438000339	MobA-like NTP transferase domain; Region: NTP_transf_3; pfam12804
370438000340	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
370438000341	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
370438000342	Coenzyme A binding pocket [chemical binding]; other site
370438000343	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
370438000344	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
370438000345	putative active site [active]
370438000346	heme pocket [chemical binding]; other site
370438000347	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
370438000348	dimer interface [polypeptide binding]; other site
370438000349	phosphorylation site [posttranslational modification]
370438000350	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
370438000351	ATP binding site [chemical binding]; other site
370438000352	Mg2+ binding site [ion binding]; other site
370438000353	G-X-G motif; other site
370438000354	threonine dehydratase; Provisional; Region: PRK08198
370438000355	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
370438000356	tetramer interface [polypeptide binding]; other site
370438000357	pyridoxal 5'-phosphate binding site [chemical binding]; other site
370438000358	catalytic residue [active]
370438000359	C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886
370438000360	regulatory protein SpoVG; Reviewed; Region: PRK13259
370438000361	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14354
370438000362	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
370438000363	Substrate binding site; other site
370438000364	Mg++ binding site; other site
370438000365	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
370438000366	active site
370438000367	substrate binding site [chemical binding]; other site
370438000368	CoA binding site [chemical binding]; other site
370438000369	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
370438000370	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
370438000371	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
370438000372	active site
370438000373	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
370438000374	Major Facilitator Superfamily; Region: MFS_1; pfam07690
370438000375	putative substrate translocation pore; other site
370438000376	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
370438000377	H+ Antiporter protein; Region: 2A0121; TIGR00900
370438000378	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
370438000379	putative substrate translocation pore; other site
370438000380	PilZ domain; Region: PilZ; pfam07238
370438000381	heat shock protein 90; Provisional; Region: PRK05218
370438000382	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
370438000383	ATP binding site [chemical binding]; other site
370438000384	Mg2+ binding site [ion binding]; other site
370438000385	G-X-G motif; other site
370438000386	PRC-barrel domain containing protein [General function prediction only]; Region: COG3881
370438000387	PRC-barrel domain; Region: PRC; pfam05239
370438000388	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
370438000389	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
370438000390	5S rRNA interface [nucleotide binding]; other site
370438000391	CTC domain interface [polypeptide binding]; other site
370438000392	L16 interface [polypeptide binding]; other site
370438000393	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
370438000394	putative active site [active]
370438000395	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
370438000396	DEAD-like helicases superfamily; Region: DEXDc; smart00487
370438000397	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
370438000398	ATP binding site [chemical binding]; other site
370438000399	putative Mg++ binding site [ion binding]; other site
370438000400	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
370438000401	nucleotide binding region [chemical binding]; other site
370438000402	ATP-binding site [chemical binding]; other site
370438000403	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
370438000404	SurA N-terminal domain; Region: SurA_N_3; cl07813
370438000405	nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933
370438000406	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
370438000407	stage V sporulation protein T; Region: spore_V_T; TIGR02851
370438000408	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; pfam04014
370438000409	GAF domain; Region: GAF; cl17456
370438000410	N-terminal S-AdoMet dependent methylase domain of Bacillus subtilis YabN and related proteins; Region: YabN_N; cd11723
370438000411	Protein containing tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain [General function prediction only]; Region: COG3956
370438000412	putative SAM binding site [chemical binding]; other site
370438000413	putative homodimer interface [polypeptide binding]; other site
370438000414	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
370438000415	homodimer interface [polypeptide binding]; other site
370438000416	metal binding site [ion binding]; metal-binding site
370438000417	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
370438000418	homodimer interface [polypeptide binding]; other site
370438000419	active site
370438000420	putative chemical substrate binding site [chemical binding]; other site
370438000421	metal binding site [ion binding]; metal-binding site
370438000422	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
370438000423	IHF dimer interface [polypeptide binding]; other site
370438000424	IHF - DNA interface [nucleotide binding]; other site
370438000425	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
370438000426	RNA binding surface [nucleotide binding]; other site
370438000427	Stage II sporulation protein; Region: SpoIID; pfam08486
370438000428	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
370438000429	YabP family; Region: YabP; cl06766
370438000430	Spore cortex protein YabQ (Spore_YabQ); Region: Spore_YabQ; pfam09578
370438000431	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
370438000432	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719
370438000433	GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522
370438000434	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
370438000435	Probable Catalytic site; other site
370438000436	transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282
370438000437	alkylhydroperoxidase/carboxymuconolactone decarboxylase family protein; Region: perox_w_seleSAM; TIGR04169
370438000438	radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167
370438000439	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370438000440	FeS/SAM binding site; other site
370438000441	Protein of unknown function (DUF3641); Region: DUF3641; pfam12345
370438000442	Uncharacterized conserved protein [Function unknown]; Region: COG0398
370438000443	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
370438000444	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
370438000445	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
370438000446	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
370438000447	active site residue [active]
370438000448	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
370438000449	active site residue [active]
370438000450	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
370438000451	active site
370438000452	NTP binding site [chemical binding]; other site
370438000453	metal binding triad [ion binding]; metal-binding site
370438000454	HEPN domain; Region: HEPN; pfam05168
370438000455	AAA domain; Region: AAA_21; pfam13304
370438000456	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
370438000457	ABC transporter signature motif; other site
370438000458	Walker B; other site
370438000459	D-loop; other site
370438000460	H-loop/switch region; other site
370438000461	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
370438000462	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
370438000463	Protein kinase domain; Region: Pkinase; pfam00069
370438000464	Catalytic domain of Protein Kinases; Region: PKc; cd00180
370438000465	active site
370438000466	ATP binding site [chemical binding]; other site
370438000467	substrate binding site [chemical binding]; other site
370438000468	activation loop (A-loop); other site
370438000469	AAA ATPase domain; Region: AAA_16; pfam13191
370438000470	Predicted ATPase [General function prediction only]; Region: COG3899
370438000471	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
370438000472	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
370438000473	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
370438000474	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
370438000475	dimer interface [polypeptide binding]; other site
370438000476	phosphorylation site [posttranslational modification]
370438000477	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
370438000478	ATP binding site [chemical binding]; other site
370438000479	Mg2+ binding site [ion binding]; other site
370438000480	G-X-G motif; other site
370438000481	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
370438000482	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370438000483	active site
370438000484	phosphorylation site [posttranslational modification]
370438000485	intermolecular recognition site; other site
370438000486	dimerization interface [polypeptide binding]; other site
370438000487	FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198
370438000488	putative binding surface; other site
370438000489	active site
370438000490	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
370438000491	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370438000492	active site
370438000493	phosphorylation site [posttranslational modification]
370438000494	intermolecular recognition site; other site
370438000495	dimerization interface [polypeptide binding]; other site
370438000496	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
370438000497	DNA binding site [nucleotide binding]
370438000498	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
370438000499	Zn2+ binding site [ion binding]; other site
370438000500	Mg2+ binding site [ion binding]; other site
370438000501	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
370438000502	Mn-containing catalase [Inorganic ion transport and metabolism]; Region: COG3546
370438000503	dinuclear metal binding motif [ion binding]; other site
370438000504	Archaeal ATPase; Region: Arch_ATPase; pfam01637
370438000505	AAA ATPase domain; Region: AAA_16; pfam13191
370438000506	Suppression of tumorigenicity 7; Region: ST7; cd11557
370438000507	Transposase [DNA replication, recombination, and repair]; Region: COG5421
370438000508	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
370438000509	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
370438000510	DNA methylase; Region: N6_N4_Mtase; cl17433
370438000511	DNA methylase; Region: N6_N4_Mtase; pfam01555
370438000512	DNA methylase; Region: N6_N4_Mtase; cl17433
370438000513	Restriction endonuclease [Defense mechanisms]; Region: COG3587
370438000514	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
370438000515	ATP binding site [chemical binding]; other site
370438000516	putative Mg++ binding site [ion binding]; other site
370438000517	Protein of unknown function DUF262; Region: DUF262; pfam03235
370438000518	Uncharacterized conserved protein [Function unknown]; Region: COG1479
370438000519	Uncharacterized conserved protein [Function unknown]; Region: COG4938
370438000520	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
370438000521	Walker A/P-loop; other site
370438000522	ATP binding site [chemical binding]; other site
370438000523	Protein of unknown function (DUF3696); Region: DUF3696; pfam12476
370438000524	Domain of unknown function (DUF4338); Region: DUF4338; pfam14236
370438000525	NurA nuclease; Region: NurA; smart00933
370438000526	AAA-like domain; Region: AAA_10; pfam12846
370438000527	Domain of unknown function DUF87; Region: DUF87; pfam01935
370438000528	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
370438000529	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
370438000530	catalytic residues [active]
370438000531	catalytic nucleophile [active]
370438000532	Presynaptic Site I dimer interface [polypeptide binding]; other site
370438000533	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
370438000534	Synaptic Flat tetramer interface [polypeptide binding]; other site
370438000535	Synaptic Site I dimer interface [polypeptide binding]; other site
370438000536	DNA binding site [nucleotide binding]
370438000537	Recombinase; Region: Recombinase; pfam07508
370438000538	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
370438000539	Domain of unknown function (DUF1998); Region: DUF1998; pfam09369
370438000540	Helix-turn-helix domain; Region: HTH_36; pfam13730
370438000541	RRXRR protein; Region: RRXRR; pfam14239
370438000542	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
370438000543	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
370438000544	non-specific DNA binding site [nucleotide binding]; other site
370438000545	salt bridge; other site
370438000546	sequence-specific DNA binding site [nucleotide binding]; other site
370438000547	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315
370438000548	DNA binding residues [nucleotide binding]
370438000549	Protein of unknown function (DUF3782); Region: DUF3782; pfam12644
370438000550	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
370438000551	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
370438000552	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
370438000553	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
370438000554	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
370438000555	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
370438000556	active site
370438000557	catalytic residues [active]
370438000558	Int/Topo IB signature motif; other site
370438000559	DNA binding site [nucleotide binding]
370438000560	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
370438000561	non-specific DNA binding site [nucleotide binding]; other site
370438000562	salt bridge; other site
370438000563	sequence-specific DNA binding site [nucleotide binding]; other site
370438000564	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
370438000565	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
370438000566	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
370438000567	catalytic residues [active]
370438000568	catalytic nucleophile [active]
370438000569	Recombinase; Region: Recombinase; pfam07508
370438000570	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
370438000571	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264
370438000572	CotJB protein; Region: CotJB; pfam12652
370438000573	Spore coat associated protein JA (CotJA); Region: CotJA; pfam11007
370438000574	Stage II sporulation protein R (spore_II_R); Region: Spore_II_R; pfam09551
370438000575	S-layer homology domain; Region: SLH; pfam00395
370438000576	S-layer homology domain; Region: SLH; pfam00395
370438000577	Bacterial Ig-like domain; Region: Big_5; pfam13205
370438000578	Bacterial Ig-like domain; Region: Big_5; pfam13205
370438000579	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
370438000580	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
370438000581	Septum formation initiator; Region: DivIC; pfam04977
370438000582	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
370438000583	hypothetical protein; Provisional; Region: PRK08582
370438000584	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
370438000585	RNA binding site [nucleotide binding]; other site
370438000586	exopolyphosphatase; Region: exo_poly_only; TIGR03706
370438000587	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
370438000588	stage II sporulation protein E; Region: spore_II_E; TIGR02865
370438000589	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
370438000590	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
370438000591	S-layer homology domain; Region: SLH; pfam00395
370438000592	S-layer homology domain; Region: SLH; pfam00395
370438000593	S-layer homology domain; Region: SLH; pfam00395
370438000594	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
370438000595	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
370438000596	Interdomain contacts; other site
370438000597	Cytokine receptor motif; other site
370438000598	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
370438000599	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
370438000600	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
370438000601	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
370438000602	Ligand Binding Site [chemical binding]; other site
370438000603	TilS substrate binding domain; Region: TilS; pfam09179
370438000604	TilS substrate C-terminal domain; Region: TilS_C; smart00977
370438000605	FtsH Extracellular; Region: FtsH_ext; pfam06480
370438000606	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
370438000607	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438000608	Walker A motif; other site
370438000609	ATP binding site [chemical binding]; other site
370438000610	Walker B motif; other site
370438000611	arginine finger; other site
370438000612	Peptidase family M41; Region: Peptidase_M41; pfam01434
370438000613	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
370438000614	active site
370438000615	multimer interface [polypeptide binding]; other site
370438000616	Formyltetrahydrofolate synthetase [Nucleotide transport and metabolism]; Region: MIS1; COG2759
370438000617	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
370438000618	Potassium binding sites [ion binding]; other site
370438000619	Cesium cation binding sites [ion binding]; other site
370438000620	Cache domain; Region: Cache_1; pfam02743
370438000621	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
370438000622	dimerization interface [polypeptide binding]; other site
370438000623	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
370438000624	dimer interface [polypeptide binding]; other site
370438000625	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
370438000626	putative CheW interface [polypeptide binding]; other site
370438000627	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
370438000628	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
370438000629	dimerization interface [polypeptide binding]; other site
370438000630	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
370438000631	dimer interface [polypeptide binding]; other site
370438000632	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
370438000633	putative CheW interface [polypeptide binding]; other site
370438000634	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
370438000635	dihydropteroate synthase; Region: DHPS; TIGR01496
370438000636	substrate binding pocket [chemical binding]; other site
370438000637	dimer interface [polypeptide binding]; other site
370438000638	inhibitor binding site; inhibition site
370438000639	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
370438000640	homooctamer interface [polypeptide binding]; other site
370438000641	active site
370438000642	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
370438000643	catalytic center binding site [active]
370438000644	ATP binding site [chemical binding]; other site
370438000645	menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699
370438000646	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370438000647	FeS/SAM binding site; other site
370438000648	Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621
370438000649	putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700
370438000650	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370438000651	FeS/SAM binding site; other site
370438000652	Purine nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pnp; COG0005
370438000653	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
370438000654	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
370438000655	YsiA-like protein, C-terminal region; Region: TetR_C_4; pfam08359
370438000656	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
370438000657	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370438000658	FeS/SAM binding site; other site
370438000659	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
370438000660	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
370438000661	active site
370438000662	DNA binding site [nucleotide binding]
370438000663	Int/Topo IB signature motif; other site
370438000664	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
370438000665	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
370438000666	active site
370438000667	DNA binding site [nucleotide binding]
370438000668	Int/Topo IB signature motif; other site
370438000669	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
370438000670	DNA methylase; Region: N6_N4_Mtase; pfam01555
370438000671	DNA methylase; Region: N6_N4_Mtase; pfam01555
370438000672	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
370438000673	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
370438000674	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
370438000675	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
370438000676	Uncharacterized conserved protein [Function unknown]; Region: COG5495
370438000677	Rossmann-like domain; Region: Rossmann-like; pfam10727
370438000678	Domain of unknown function (DUF2520); Region: DUF2520; pfam10728
370438000679	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
370438000680	oligomerization interface [polypeptide binding]; other site
370438000681	active site
370438000682	metal binding site [ion binding]; metal-binding site
370438000683	pantoate--beta-alanine ligase; Region: panC; TIGR00018
370438000684	Pantoate-beta-alanine ligase; Region: PanC; cd00560
370438000685	active site
370438000686	ATP-binding site [chemical binding]; other site
370438000687	pantoate-binding site; other site
370438000688	HXXH motif; other site
370438000689	Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent  decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919
370438000690	tetramerization interface [polypeptide binding]; other site
370438000691	active site
370438000692	Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029
370438000693	L-aspartate oxidase; Provisional; Region: PRK06175
370438000694	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
370438000695	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
370438000696	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
370438000697	dimerization interface [polypeptide binding]; other site
370438000698	active site
370438000699	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
370438000700	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
370438000701	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
370438000702	catalytic residue [active]
370438000703	Quinolinate synthetase A protein; Region: NadA; pfam02445
370438000704	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
370438000705	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
370438000706	metal-binding site [ion binding]
370438000707	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
370438000708	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
370438000709	metal-binding site [ion binding]
370438000710	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
370438000711	Soluble P-type ATPase [General function prediction only]; Region: COG4087
370438000712	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
370438000713	dimerization interface [polypeptide binding]; other site
370438000714	putative DNA binding site [nucleotide binding]; other site
370438000715	putative Zn2+ binding site [ion binding]; other site
370438000716	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
370438000717	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
370438000718	Soluble P-type ATPase [General function prediction only]; Region: COG4087
370438000719	Predicted transcriptional regulator [Transcription]; Region: COG1959
370438000720	Transcriptional regulator; Region: Rrf2; cl17282
370438000721	ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728
370438000722	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
370438000723	substrate binding pocket [chemical binding]; other site
370438000724	membrane-bound complex binding site; other site
370438000725	hinge residues; other site
370438000726	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
370438000727	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
370438000728	Walker A/P-loop; other site
370438000729	ATP binding site [chemical binding]; other site
370438000730	Q-loop/lid; other site
370438000731	ABC transporter signature motif; other site
370438000732	Walker B; other site
370438000733	D-loop; other site
370438000734	H-loop/switch region; other site
370438000735	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
370438000736	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
370438000737	ABC-ATPase subunit interface; other site
370438000738	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
370438000739	AAA domain; Region: AAA_18; pfam13238
370438000740	ligand-binding site [chemical binding]; other site
370438000741	adenylylsulfate reductase subunit alpha; Validated; Region: PRK06854
370438000742	L-aspartate oxidase; Provisional; Region: PRK06175
370438000743	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
370438000744	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
370438000745	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
370438000746	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
370438000747	ATP-sulfurylase; Region: ATPS; cd00517
370438000748	active site
370438000749	HXXH motif; other site
370438000750	flexible loop; other site
370438000751	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
370438000752	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
370438000753	4Fe-4S binding domain; Region: Fer4; pfam00037
370438000754	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
370438000755	CPxP  motif; other site
370438000756	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
370438000757	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
370438000758	ATP binding site [chemical binding]; other site
370438000759	substrate interface [chemical binding]; other site
370438000760	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
370438000761	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370438000762	active site
370438000763	phosphorylation site [posttranslational modification]
370438000764	intermolecular recognition site; other site
370438000765	dimerization interface [polypeptide binding]; other site
370438000766	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
370438000767	DNA binding site [nucleotide binding]
370438000768	two-component sensor protein; Provisional; Region: cpxA; PRK09470
370438000769	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
370438000770	dimerization interface [polypeptide binding]; other site
370438000771	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
370438000772	dimer interface [polypeptide binding]; other site
370438000773	phosphorylation site [posttranslational modification]
370438000774	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
370438000775	ATP binding site [chemical binding]; other site
370438000776	Mg2+ binding site [ion binding]; other site
370438000777	G-X-G motif; other site
370438000778	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
370438000779	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
370438000780	dimer interface [polypeptide binding]; other site
370438000781	pyridoxal 5'-phosphate binding site [chemical binding]; other site
370438000782	catalytic residue [active]
370438000783	Biotin and Thiamin Synthesis associated domain; Region: BATS; cl06149
370438000784	biotin synthase; Provisional; Region: PRK07094
370438000785	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370438000786	FeS/SAM binding site; other site
370438000787	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
370438000788	homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392
370438000789	homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175
370438000790	Methyltransferase domain; Region: Methyltransf_23; pfam13489
370438000791	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
370438000792	S-adenosylmethionine binding site [chemical binding]; other site
370438000793	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
370438000794	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
370438000795	Ligand Binding Site [chemical binding]; other site
370438000796	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
370438000797	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
370438000798	homodimer interface [polypeptide binding]; other site
370438000799	substrate-cofactor binding pocket; other site
370438000800	pyridoxal 5'-phosphate binding site [chemical binding]; other site
370438000801	catalytic residue [active]
370438000802	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
370438000803	putative Zn2+ binding site [ion binding]; other site
370438000804	putative DNA binding site [nucleotide binding]; other site
370438000805	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057
370438000806	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
370438000807	BioY family; Region: BioY; pfam02632
370438000808	Late competence development protein ComFB; Region: ComFB; pfam10719
370438000809	pantothenate kinase; Reviewed; Region: PRK13318
370438000810	putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737
370438000811	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
370438000812	FMN binding site [chemical binding]; other site
370438000813	active site
370438000814	catalytic residues [active]
370438000815	substrate binding site [chemical binding]; other site
370438000816	Helix-turn-helix domain; Region: HTH_31; pfam13560
370438000817	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
370438000818	NAD(P) binding pocket [chemical binding]; other site
370438000819	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
370438000820	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
370438000821	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
370438000822	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
370438000823	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
370438000824	dimer interface [polypeptide binding]; other site
370438000825	putative anticodon binding site; other site
370438000826	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
370438000827	motif 1; other site
370438000828	active site
370438000829	motif 2; other site
370438000830	motif 3; other site
370438000831	PrcB C-terminal; Region: PrcB_C; pfam14343
370438000832	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
370438000833	Purine catabolism regulatory protein-like family; Region: PucR; pfam07905
370438000834	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
370438000835	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
370438000836	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
370438000837	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
370438000838	active site
370438000839	FMN binding site [chemical binding]; other site
370438000840	substrate binding site [chemical binding]; other site
370438000841	putative catalytic residue [active]
370438000842	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
370438000843	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
370438000844	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
370438000845	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
370438000846	putative acyltransferase; Provisional; Region: PRK05790
370438000847	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
370438000848	dimer interface [polypeptide binding]; other site
370438000849	active site
370438000850	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
370438000851	Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258
370438000852	putative NAD(P) binding site [chemical binding]; other site
370438000853	catalytic Zn binding site [ion binding]; other site
370438000854	structural Zn binding site [ion binding]; other site
370438000855	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK06130
370438000856	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
370438000857	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
370438000858	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
370438000859	Short chain fatty acids transporter [Lipid metabolism]; Region: AtoE; COG2031
370438000860	Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878
370438000861	ABC-2 family transporter protein; Region: ABC2_membrane_5; pfam13346
370438000862	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
370438000863	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
370438000864	Walker A/P-loop; other site
370438000865	ATP binding site [chemical binding]; other site
370438000866	Q-loop/lid; other site
370438000867	ABC transporter signature motif; other site
370438000868	Walker B; other site
370438000869	D-loop; other site
370438000870	H-loop/switch region; other site
370438000871	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
370438000872	DNA-binding site [nucleotide binding]; DNA binding site
370438000873	Firmicute transcriptional repressor of class III stress genes (CtsR); Region: CtsR; pfam05848
370438000874	Modulator of heat shock repressor CtsR, McsA [Signal transduction    mechanisms]; Region: COG3880
370438000875	UvrB/uvrC motif; Region: UVR; pfam02151
370438000876	ATP:guanido phosphotransferase; Provisional; Region: PRK01059
370438000877	Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930
370438000878	ADP binding site [chemical binding]; other site
370438000879	phosphagen binding site; other site
370438000880	substrate specificity loop; other site
370438000881	Clp protease ATP binding subunit; Region: clpC; CHL00095
370438000882	Clp amino terminal domain; Region: Clp_N; pfam02861
370438000883	Clp amino terminal domain; Region: Clp_N; pfam02861
370438000884	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438000885	Walker A motif; other site
370438000886	ATP binding site [chemical binding]; other site
370438000887	Walker B motif; other site
370438000888	arginine finger; other site
370438000889	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438000890	Walker A motif; other site
370438000891	ATP binding site [chemical binding]; other site
370438000892	Walker B motif; other site
370438000893	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
370438000894	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943
370438000895	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cl07055
370438000896	DnaA box-binding interface [nucleotide binding]; other site
370438000897	DNA repair protein RadA; Provisional; Region: PRK11823
370438000898	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
370438000899	Walker A motif/ATP binding site; other site
370438000900	ATP binding site [chemical binding]; other site
370438000901	Walker B motif; other site
370438000902	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
370438000903	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
370438000904	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
370438000905	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
370438000906	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
370438000907	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
370438000908	Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956
370438000909	PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877
370438000910	putative active site [active]
370438000911	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
370438000912	substrate binding site; other site
370438000913	dimer interface; other site
370438000914	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
370438000915	homotrimer interaction site [polypeptide binding]; other site
370438000916	zinc binding site [ion binding]; other site
370438000917	CDP-binding sites; other site
370438000918	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
370438000919	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
370438000920	HIGH motif; other site
370438000921	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
370438000922	active site
370438000923	KMSKS motif; other site
370438000924	Serine acetyltransferase [Amino acid transport and metabolism]; Region: CysE; COG1045
370438000925	Serine acetyltransferase, N-terminal; Region: SATase_N; cl05762
370438000926	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
370438000927	trimer interface [polypeptide binding]; other site
370438000928	active site
370438000929	substrate binding site [chemical binding]; other site
370438000930	CoA binding site [chemical binding]; other site
370438000931	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
370438000932	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
370438000933	active site
370438000934	HIGH motif; other site
370438000935	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
370438000936	KMSKS motif; other site
370438000937	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
370438000938	tRNA binding surface [nucleotide binding]; other site
370438000939	anticodon binding site; other site
370438000940	Ribonuclease III family protein [Replication, recombination, and    repair]; Region: COG1939
370438000941	active site
370438000942	metal binding site [ion binding]; metal-binding site
370438000943	dimerization interface [polypeptide binding]; other site
370438000944	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
370438000945	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
370438000946	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
370438000947	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
370438000948	YacP-like NYN domain; Region: NYN_YacP; pfam05991
370438000949	RNA polymerase factor sigma-70; Validated; Region: PRK08295
370438000950	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
370438000951	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
370438000952	elongation factor Tu; Reviewed; Region: PRK00049
370438000953	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
370438000954	G1 box; other site
370438000955	GEF interaction site [polypeptide binding]; other site
370438000956	GTP/Mg2+ binding site [chemical binding]; other site
370438000957	Switch I region; other site
370438000958	G2 box; other site
370438000959	G3 box; other site
370438000960	Switch II region; other site
370438000961	G4 box; other site
370438000962	G5 box; other site
370438000963	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
370438000964	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
370438000965	Antibiotic Binding Site [chemical binding]; other site
370438000966	50S ribosomal protein L33; Validated; Region: rpmG; PRK00504
370438000967	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
370438000968	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
370438000969	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
370438000970	putative homodimer interface [polypeptide binding]; other site
370438000971	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
370438000972	heterodimer interface [polypeptide binding]; other site
370438000973	homodimer interface [polypeptide binding]; other site
370438000974	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
370438000975	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
370438000976	23S rRNA interface [nucleotide binding]; other site
370438000977	L7/L12 interface [polypeptide binding]; other site
370438000978	putative thiostrepton binding site; other site
370438000979	L25 interface [polypeptide binding]; other site
370438000980	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
370438000981	mRNA/rRNA interface [nucleotide binding]; other site
370438000982	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
370438000983	23S rRNA interface [nucleotide binding]; other site
370438000984	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
370438000985	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
370438000986	peripheral dimer interface [polypeptide binding]; other site
370438000987	core dimer interface [polypeptide binding]; other site
370438000988	L10 interface [polypeptide binding]; other site
370438000989	L11 interface [polypeptide binding]; other site
370438000990	putative EF-Tu interaction site [polypeptide binding]; other site
370438000991	putative EF-G interaction site [polypeptide binding]; other site
370438000992	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
370438000993	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
370438000994	metal binding site [ion binding]; metal-binding site
370438000995	active site
370438000996	I-site; other site
370438000997	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
370438000998	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
370438000999	Zn2+ binding site [ion binding]; other site
370438001000	Mg2+ binding site [ion binding]; other site
370438001001	Uncharacterized conserved protein [Function unknown]; Region: COG3287
370438001002	FIST N domain; Region: FIST; pfam08495
370438001003	FIST C domain; Region: FIST_C; pfam10442
370438001004	RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563
370438001005	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
370438001006	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
370438001007	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
370438001008	RPB10 interaction site [polypeptide binding]; other site
370438001009	RPB11 interaction site [polypeptide binding]; other site
370438001010	RPB3 interaction site [polypeptide binding]; other site
370438001011	RPB12 interaction site [polypeptide binding]; other site
370438001012	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
370438001013	RPB1 interaction site [polypeptide binding]; other site
370438001014	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
370438001015	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
370438001016	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
370438001017	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
370438001018	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
370438001019	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
370438001020	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
370438001021	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
370438001022	G-loop; other site
370438001023	DNA binding site [nucleotide binding]
370438001024	putative ribosomal protein L7Ae-like; Provisional; Region: PRK13602
370438001025	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
370438001026	S17 interaction site [polypeptide binding]; other site
370438001027	S8 interaction site; other site
370438001028	16S rRNA interaction site [nucleotide binding]; other site
370438001029	streptomycin interaction site [chemical binding]; other site
370438001030	23S rRNA interaction site [nucleotide binding]; other site
370438001031	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
370438001032	30S ribosomal protein S7; Validated; Region: PRK05302
370438001033	elongation factor G; Reviewed; Region: PRK00007
370438001034	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
370438001035	G1 box; other site
370438001036	putative GEF interaction site [polypeptide binding]; other site
370438001037	GTP/Mg2+ binding site [chemical binding]; other site
370438001038	Switch I region; other site
370438001039	G2 box; other site
370438001040	G3 box; other site
370438001041	Switch II region; other site
370438001042	G4 box; other site
370438001043	G5 box; other site
370438001044	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
370438001045	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
370438001046	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
370438001047	elongation factor Tu; Reviewed; Region: PRK00049
370438001048	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
370438001049	G1 box; other site
370438001050	GEF interaction site [polypeptide binding]; other site
370438001051	GTP/Mg2+ binding site [chemical binding]; other site
370438001052	Switch I region; other site
370438001053	G2 box; other site
370438001054	G3 box; other site
370438001055	Switch II region; other site
370438001056	G4 box; other site
370438001057	G5 box; other site
370438001058	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
370438001059	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
370438001060	Antibiotic Binding Site [chemical binding]; other site
370438001061	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
370438001062	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
370438001063	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
370438001064	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
370438001065	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
370438001066	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
370438001067	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
370438001068	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
370438001069	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
370438001070	putative translocon binding site; other site
370438001071	protein-rRNA interface [nucleotide binding]; other site
370438001072	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
370438001073	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
370438001074	G-X-X-G motif; other site
370438001075	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
370438001076	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
370438001077	23S rRNA interface [nucleotide binding]; other site
370438001078	5S rRNA interface [nucleotide binding]; other site
370438001079	putative antibiotic binding site [chemical binding]; other site
370438001080	L25 interface [polypeptide binding]; other site
370438001081	L27 interface [polypeptide binding]; other site
370438001082	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
370438001083	23S rRNA interface [nucleotide binding]; other site
370438001084	putative translocon interaction site; other site
370438001085	signal recognition particle (SRP54) interaction site; other site
370438001086	L23 interface [polypeptide binding]; other site
370438001087	trigger factor interaction site; other site
370438001088	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
370438001089	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
370438001090	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
370438001091	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
370438001092	RNA binding site [nucleotide binding]; other site
370438001093	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
370438001094	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
370438001095	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
370438001096	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
370438001097	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
370438001098	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
370438001099	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
370438001100	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
370438001101	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
370438001102	5S rRNA interface [nucleotide binding]; other site
370438001103	L5 interface [polypeptide binding]; other site
370438001104	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
370438001105	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
370438001106	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
370438001107	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
370438001108	23S rRNA binding site [nucleotide binding]; other site
370438001109	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
370438001110	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
370438001111	SecY translocase; Region: SecY; pfam00344
370438001112	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
370438001113	active site
370438001114	KOW motif of Ribosomal Protein L14; Region: KOW_RPL14; cd06088
370438001115	RNA binding site [nucleotide binding]; other site
370438001116	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
370438001117	rRNA binding site [nucleotide binding]; other site
370438001118	predicted 30S ribosome binding site; other site
370438001119	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
370438001120	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
370438001121	30S ribosomal protein S13; Region: bact_S13; TIGR03631
370438001122	30S ribosomal protein S11; Validated; Region: PRK05309
370438001123	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
370438001124	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
370438001125	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
370438001126	RNA binding surface [nucleotide binding]; other site
370438001127	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
370438001128	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
370438001129	alphaNTD - beta interaction site [polypeptide binding]; other site
370438001130	alphaNTD homodimer interface [polypeptide binding]; other site
370438001131	alphaNTD - beta' interaction site [polypeptide binding]; other site
370438001132	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
370438001133	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
370438001134	cobalt transporter ATP-binding subunit; Provisional; Region: PRK13633
370438001135	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
370438001136	Walker A/P-loop; other site
370438001137	ATP binding site [chemical binding]; other site
370438001138	Q-loop/lid; other site
370438001139	ABC transporter signature motif; other site
370438001140	Walker B; other site
370438001141	D-loop; other site
370438001142	H-loop/switch region; other site
370438001143	Protein of unknown function (DUF1602); Region: DUF1602; pfam07673
370438001144	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13637
370438001145	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
370438001146	Walker A/P-loop; other site
370438001147	ATP binding site [chemical binding]; other site
370438001148	Q-loop/lid; other site
370438001149	ABC transporter signature motif; other site
370438001150	Walker B; other site
370438001151	D-loop; other site
370438001152	H-loop/switch region; other site
370438001153	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
370438001154	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
370438001155	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
370438001156	dimerization interface 3.5A [polypeptide binding]; other site
370438001157	active site
370438001158	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
370438001159	23S rRNA interface [nucleotide binding]; other site
370438001160	L3 interface [polypeptide binding]; other site
370438001161	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
370438001162	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
370438001163	active site
370438001164	NTP binding site [chemical binding]; other site
370438001165	metal binding triad [ion binding]; metal-binding site
370438001166	antibiotic binding site [chemical binding]; other site
370438001167	Protein of unknown function (DUF2837); Region: DUF2837; pfam10997
370438001168	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
370438001169	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
370438001170	active site
370438001171	metal binding site [ion binding]; metal-binding site
370438001172	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
370438001173	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
370438001174	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
370438001175	putative active site [active]
370438001176	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
370438001177	HTH-like domain; Region: HTH_21; pfam13276
370438001178	Integrase core domain; Region: rve; pfam00665
370438001179	Integrase core domain; Region: rve_3; pfam13683
370438001180	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
370438001181	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
370438001182	Cupin domain; Region: Cupin_2; cl17218
370438001183	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
370438001184	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
370438001185	putative active site [active]
370438001186	Protein of unknown function (DUF1616); Region: DUF1616; pfam07760
370438001187	CAAX protease self-immunity; Region: Abi; pfam02517
370438001188	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
370438001189	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
370438001190	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
370438001191	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
370438001192	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
370438001193	Bacterial transferase hexapeptide (six repeats); Region: Hexapep; pfam00132
370438001194	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
370438001195	putative CoA binding site [chemical binding]; other site
370438001196	putative trimer interface [polypeptide binding]; other site
370438001197	putative active site [active]
370438001198	putative substrate binding site [chemical binding]; other site
370438001199	putative CoA binding site [chemical binding]; other site
370438001200	UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; Region: UDPG_MGDP_dh_N; pfam03721
370438001201	TrkA-N domain; Region: TrkA_N; pfam02254
370438001202	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
370438001203	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; cl17747
370438001204	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
370438001205	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
370438001206	Ligand binding site; other site
370438001207	Putative Catalytic site; other site
370438001208	DXD motif; other site
370438001209	Uncharacterized protein conserved in archaea [Function unknown]; Region: COG1817
370438001210	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
370438001211	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
370438001212	active site
370438001213	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
370438001214	homodimer interface [polypeptide binding]; other site
370438001215	LanC-like proteins. LanC is the cyclase enzyme of the lanthionine synthetase. Lanthionine is a lantibiotic, a unique class of peptide antibiotics. They are ribosomally synthesized as a precursor peptide and then post-translationally modified to contain...; Region: LanC_like; cl04955
370438001216	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
370438001217	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
370438001218	acyl-activating enzyme (AAE) consensus motif; other site
370438001219	active site
370438001220	AMP binding site [chemical binding]; other site
370438001221	CoA binding site [chemical binding]; other site
370438001222	putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304
370438001223	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
370438001224	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
370438001225	Transposase domain (DUF772); Region: DUF772; pfam05598
370438001226	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
370438001227	DDE superfamily endonuclease; Region: DDE_5; cl17874
370438001228	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
370438001229	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
370438001230	Transposase domain (DUF772); Region: DUF772; pfam05598
370438001231	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
370438001232	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
370438001233	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
370438001234	inhibitor-cofactor binding pocket; inhibition site
370438001235	pyridoxal 5'-phosphate binding site [chemical binding]; other site
370438001236	catalytic residue [active]
370438001237	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
370438001238	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
370438001239	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
370438001240	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
370438001241	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
370438001242	active site
370438001243	substrate binding site [chemical binding]; other site
370438001244	metal binding site [ion binding]; metal-binding site
370438001245	The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757
370438001246	prevent-host-death family protein; Region: phd_fam; TIGR01552
370438001247	PIN domain; Region: PIN_3; cl17397
370438001248	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
370438001249	putative active site [active]
370438001250	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
370438001251	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
370438001252	ATP-binding site [chemical binding]; other site
370438001253	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
370438001254	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
370438001255	ATP-binding site [chemical binding]; other site
370438001256	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
370438001257	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
370438001258	Zn2+ binding site [ion binding]; other site
370438001259	Mg2+ binding site [ion binding]; other site
370438001260	putative septicolysin, cholesterol-dependent cytolysin family and related proteins; Region: septicolysin_like; cd12208
370438001261	oligomer interface [polypeptide binding]; other site
370438001262	Uncharacterized conserved protein [Function unknown]; Region: COG4279
370438001263	SWIM zinc finger; Region: SWIM; pfam04434
370438001264	SNF2 Helicase protein; Region: DUF3670; pfam12419
370438001265	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
370438001266	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
370438001267	ATP binding site [chemical binding]; other site
370438001268	putative Mg++ binding site [ion binding]; other site
370438001269	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
370438001270	nucleotide binding region [chemical binding]; other site
370438001271	ATP-binding site [chemical binding]; other site
370438001272	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881
370438001273	oligomeric interface; other site
370438001274	putative active site [active]
370438001275	homodimer interface [polypeptide binding]; other site
370438001276	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
370438001277	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
370438001278	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
370438001279	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
370438001280	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
370438001281	Walker A/P-loop; other site
370438001282	ATP binding site [chemical binding]; other site
370438001283	Q-loop/lid; other site
370438001284	ABC transporter signature motif; other site
370438001285	Walker B; other site
370438001286	D-loop; other site
370438001287	H-loop/switch region; other site
370438001288	S-layer homology domain; Region: SLH; pfam00395
370438001289	S-layer homology domain; Region: SLH; pfam00395
370438001290	Middle domain of rhamnogalacturonan lyase, a family 4 polysaccharide lyase; Region: RGL4_M; cd10316
370438001291	S-layer homology domain; Region: SLH; pfam00395
370438001292	S-layer homology domain; Region: SLH; pfam00395
370438001293	S-layer homology domain; Region: SLH; pfam00395
370438001294	Protein of unknown function (DUF1659); Region: DUF1659; pfam07872
370438001295	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
370438001296	antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870
370438001297	Zn binding site [ion binding]; other site
370438001298	toxin interface [polypeptide binding]; other site
370438001299	Gas vesicle protein; Region: Gas_vesicle; pfam00741
370438001300	Gas vesicle protein K; Region: GvpK; pfam05121
370438001301	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
370438001302	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
370438001303	Gas vesicle protein G; Region: GvpG; pfam05120
370438001304	Gas vesicle synthesis protein GvpL/GvpF; Region: GvpL_GvpF; pfam06386
370438001305	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438001306	ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464
370438001307	Walker A motif; other site
370438001308	ATP binding site [chemical binding]; other site
370438001309	Walker B motif; other site
370438001310	arginine finger; other site
370438001311	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438001312	Walker A motif; other site
370438001313	ATP binding site [chemical binding]; other site
370438001314	Walker B motif; other site
370438001315	arginine finger; other site
370438001316	gas vesicle protein GvpN; Region: gas_vesic_GvpN; TIGR02640
370438001317	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438001318	Walker A motif; other site
370438001319	ATP binding site [chemical binding]; other site
370438001320	Walker B motif; other site
370438001321	arginine finger; other site
370438001322	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
370438001323	Gas vesicle synthesis protein GvpO; Region: GvpO; pfam05800
370438001324	gas vesicle synthesis protein GvpA; Provisional; Region: PRK09371
370438001325	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
370438001326	active site
370438001327	NTP binding site [chemical binding]; other site
370438001328	metal binding triad [ion binding]; metal-binding site
370438001329	HEPN domain; Region: HEPN; pfam05168
370438001330	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
370438001331	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
370438001332	active site
370438001333	metal binding site [ion binding]; metal-binding site
370438001334	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
370438001335	putative DNA binding site [nucleotide binding]; other site
370438001336	putative Zn2+ binding site [ion binding]; other site
370438001337	Methyltransferase domain; Region: Methyltransf_31; pfam13847
370438001338	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
370438001339	S-adenosylmethionine binding site [chemical binding]; other site
370438001340	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
370438001341	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
370438001342	NAD binding site [chemical binding]; other site
370438001343	homodimer interface [polypeptide binding]; other site
370438001344	active site
370438001345	substrate binding site [chemical binding]; other site
370438001346	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
370438001347	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
370438001348	Domain of unknown function DUF20; Region: UPF0118; pfam01594
370438001349	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
370438001350	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
370438001351	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
370438001352	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
370438001353	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
370438001354	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
370438001355	putative Zn2+ binding site [ion binding]; other site
370438001356	putative DNA binding site [nucleotide binding]; other site
370438001357	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
370438001358	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
370438001359	Thermotoga maritima CorA-like family; Region: TmCorA-like; cd12822
370438001360	oligomer interface [polypeptide binding]; other site
370438001361	metal binding site [ion binding]; metal-binding site
370438001362	metal binding site [ion binding]; metal-binding site
370438001363	putative Cl binding site [ion binding]; other site
370438001364	aspartate ring; other site
370438001365	basic sphincter; other site
370438001366	hydrophobic gate; other site
370438001367	periplasmic entrance; other site
370438001368	Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265
370438001369	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
370438001370	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
370438001371	protein binding site [polypeptide binding]; other site
370438001372	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
370438001373	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370438001374	active site
370438001375	phosphorylation site [posttranslational modification]
370438001376	intermolecular recognition site; other site
370438001377	dimerization interface [polypeptide binding]; other site
370438001378	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
370438001379	DNA binding site [nucleotide binding]
370438001380	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
370438001381	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
370438001382	dimerization interface [polypeptide binding]; other site
370438001383	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
370438001384	dimer interface [polypeptide binding]; other site
370438001385	phosphorylation site [posttranslational modification]
370438001386	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
370438001387	ATP binding site [chemical binding]; other site
370438001388	Mg2+ binding site [ion binding]; other site
370438001389	G-X-G motif; other site
370438001390	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
370438001391	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
370438001392	transmembrane helices; other site
370438001393	Septation ring formation regulator, EzrA; Region: EzrA; pfam06160
370438001394	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
370438001395	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
370438001396	transmembrane helices; other site
370438001397	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
370438001398	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
370438001399	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
370438001400	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
370438001401	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
370438001402	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
370438001403	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
370438001404	TM-ABC transporter signature motif; other site
370438001405	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
370438001406	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
370438001407	TM-ABC transporter signature motif; other site
370438001408	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
370438001409	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
370438001410	Walker A/P-loop; other site
370438001411	ATP binding site [chemical binding]; other site
370438001412	Q-loop/lid; other site
370438001413	ABC transporter signature motif; other site
370438001414	Walker B; other site
370438001415	D-loop; other site
370438001416	H-loop/switch region; other site
370438001417	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
370438001418	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
370438001419	Walker A/P-loop; other site
370438001420	ATP binding site [chemical binding]; other site
370438001421	Q-loop/lid; other site
370438001422	ABC transporter signature motif; other site
370438001423	Walker B; other site
370438001424	D-loop; other site
370438001425	H-loop/switch region; other site
370438001426	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
370438001427	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
370438001428	LysE type translocator; Region: LysE; cl00565
370438001429	hypothetical protein; Provisional; Region: PRK03881
370438001430	The N-terminal domain, an extradiol dioxygenase class III subunit B-like domain, of unknown proteins containing a C-terminal AMMECR1 domain; Region: ED_3B_N_AMMECR1; cd07951
370438001431	AMMECR1; Region: AMMECR1; pfam01871
370438001432	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
370438001433	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370438001434	FeS/SAM binding site; other site
370438001435	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
370438001436	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
370438001437	G1 box; other site
370438001438	G1 box; other site
370438001439	GTP/Mg2+ binding site [chemical binding]; other site
370438001440	GTP/Mg2+ binding site [chemical binding]; other site
370438001441	G2 box; other site
370438001442	G2 box; other site
370438001443	Switch I region; other site
370438001444	G3 box; other site
370438001445	Switch II region; other site
370438001446	G4 box; other site
370438001447	G5 box; other site
370438001448	TGS_DRG_C:   DRG (developmentally regulated GTP-binding protein) represents a family of GTP-binding proteins that includes two members, DRG1 and DRG2. DRG1 and DRG2 have a C-terminal TGS domain (named after the ThrRS, GTPase, and SpoT proteins where it...; Region: TGS_DRG_C; cd01666
370438001449	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
370438001450	EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438
370438001451	DXD motif; other site
370438001452	sulfate ABC transporter, ATP-binding protein; Region: 3a0106s01; TIGR00968
370438001453	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
370438001454	Walker A/P-loop; other site
370438001455	ATP binding site [chemical binding]; other site
370438001456	Q-loop/lid; other site
370438001457	ABC transporter signature motif; other site
370438001458	Walker B; other site
370438001459	D-loop; other site
370438001460	H-loop/switch region; other site
370438001461	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
370438001462	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
370438001463	acyl-activating enzyme (AAE) consensus motif; other site
370438001464	AMP binding site [chemical binding]; other site
370438001465	active site
370438001466	CoA binding site [chemical binding]; other site
370438001467	Catalytic NodB homology domain of Bacillus subtilis polysaccharide deacetylase PdaA, and its bacterial homologs; Region: CE4_BsPdaA_like; cd10948
370438001468	delta-lactam-biosynthetic de-N-acetylase; Region: spore_pdaA; TIGR02884
370438001469	NodB motif; other site
370438001470	active site
370438001471	catalytic site [active]
370438001472	Cd binding site [ion binding]; other site
370438001473	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
370438001474	putative FMN binding site [chemical binding]; other site
370438001475	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
370438001476	Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910
370438001477	Protein of unknown function (DUF3832); Region: DUF3832; pfam12909
370438001478	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
370438001479	Transcriptional regulator [Transcription]; Region: IclR; COG1414
370438001480	Bacterial transcriptional regulator; Region: IclR; pfam01614
370438001481	Ferredoxin [Energy production and conversion]; Region: COG1146
370438001482	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
370438001483	Quinolinate phosphoribosyl transferase, C-terminal domain; Region: QRPTase_C; pfam01729
370438001484	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
370438001485	acetaldehyde dehydrogenase; Validated; Region: PRK08300
370438001486	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
370438001487	Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290
370438001488	4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195
370438001489	4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943
370438001490	active site
370438001491	catalytic residues [active]
370438001492	metal binding site [ion binding]; metal-binding site
370438001493	DmpG-like communication domain; Region: DmpG_comm; pfam07836
370438001494	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
370438001495	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
370438001496	active site
370438001497	NAD binding site [chemical binding]; other site
370438001498	metal binding site [ion binding]; metal-binding site
370438001499	MoCF_BD: molybdenum cofactor (MoCF) binding domain (BD). This domain is found a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. The domain is presumed to bind molybdopterin; Region: MoCF_BD; cd00758
370438001500	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
370438001501	MPT binding site; other site
370438001502	Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142
370438001503	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
370438001504	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
370438001505	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
370438001506	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
370438001507	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
370438001508	NADPH-dependent butanol dehydrogenase involved in the butanol and ethanol formation pathway in bacteria; Region: NADPH_BDH; cd08179
370438001509	putative active site [active]
370438001510	metal binding site [ion binding]; metal-binding site
370438001511	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
370438001512	CoA binding domain; Region: CoA_binding_2; pfam13380
370438001513	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
370438001514	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
370438001515	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
370438001516	BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857
370438001517	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
370438001518	DRTGG domain; Region: DRTGG; pfam07085
370438001519	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
370438001520	Na binding site [ion binding]; other site
370438001521	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
370438001522	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
370438001523	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
370438001524	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
370438001525	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
370438001526	active site
370438001527	NAD binding site [chemical binding]; other site
370438001528	metal binding site [ion binding]; metal-binding site
370438001529	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977
370438001530	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
370438001531	MoaE interaction surface [polypeptide binding]; other site
370438001532	MoeB interaction surface [polypeptide binding]; other site
370438001533	thiocarboxylated glycine; other site
370438001534	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
370438001535	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
370438001536	ATP binding site [chemical binding]; other site
370438001537	substrate interface [chemical binding]; other site
370438001538	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
370438001539	putative active site [active]
370438001540	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
370438001541	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
370438001542	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
370438001543	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
370438001544	heterotetramer interface [polypeptide binding]; other site
370438001545	active site pocket [active]
370438001546	cleavage site
370438001547	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
370438001548	feedback inhibition sensing region; other site
370438001549	homohexameric interface [polypeptide binding]; other site
370438001550	nucleotide binding site [chemical binding]; other site
370438001551	N-acetyl-L-glutamate binding site [chemical binding]; other site
370438001552	acetylornithine aminotransferase; Provisional; Region: PRK02627
370438001553	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
370438001554	inhibitor-cofactor binding pocket; inhibition site
370438001555	pyridoxal 5'-phosphate binding site [chemical binding]; other site
370438001556	catalytic residue [active]
370438001557	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
370438001558	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
370438001559	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
370438001560	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
370438001561	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
370438001562	ATP-grasp domain; Region: ATP-grasp_4; cl17255
370438001563	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
370438001564	IMP binding site; other site
370438001565	dimer interface [polypeptide binding]; other site
370438001566	interdomain contacts; other site
370438001567	partial ornithine binding site; other site
370438001568	ornithine carbamoyltransferase; Provisional; Region: PRK00779
370438001569	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
370438001570	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
370438001571	argininosuccinate synthase; Provisional; Region: PRK13820
370438001572	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
370438001573	ANP binding site [chemical binding]; other site
370438001574	Substrate Binding Site II [chemical binding]; other site
370438001575	Substrate Binding Site I [chemical binding]; other site
370438001576	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
370438001577	Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: PspF; COG1221
370438001578	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438001579	Walker A motif; other site
370438001580	ATP binding site [chemical binding]; other site
370438001581	Walker B motif; other site
370438001582	arginine finger; other site
370438001583	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
370438001584	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
370438001585	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
370438001586	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
370438001587	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
370438001588	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
370438001589	dimer interface [polypeptide binding]; other site
370438001590	active site
370438001591	metal binding site [ion binding]; metal-binding site
370438001592	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
370438001593	Coenzyme A transferase; Region: CoA_trans; smart00882
370438001594	Coenzyme A transferase; Region: CoA_trans; cl17247
370438001595	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
370438001596	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
370438001597	FAD binding site [chemical binding]; other site
370438001598	homotetramer interface [polypeptide binding]; other site
370438001599	substrate binding pocket [chemical binding]; other site
370438001600	catalytic base [active]
370438001601	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
370438001602	Ligand binding site [chemical binding]; other site
370438001603	Electron transfer flavoprotein domain; Region: ETF; pfam01012
370438001604	3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809
370438001605	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
370438001606	substrate binding site [chemical binding]; other site
370438001607	oxyanion hole (OAH) forming residues; other site
370438001608	trimer interface [polypeptide binding]; other site
370438001609	argininosuccinate lyase; Provisional; Region: PRK00855
370438001610	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
370438001611	active sites [active]
370438001612	tetramer interface [polypeptide binding]; other site
370438001613	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
370438001614	Prephenate dehydratase; Region: PDT; pfam00800
370438001615	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
370438001616	putative L-Phe binding site [chemical binding]; other site
370438001617	Chorismate mutase type II; Region: CM_2; smart00830
370438001618	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
370438001619	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
370438001620	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
370438001621	biotin synthase; Region: bioB; TIGR00433
370438001622	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370438001623	FeS/SAM binding site; other site
370438001624	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
370438001625	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
370438001626	dinuclear metal binding motif [ion binding]; other site
370438001627	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
370438001628	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
370438001629	homodimer interface [polypeptide binding]; other site
370438001630	substrate-cofactor binding pocket; other site
370438001631	pyridoxal 5'-phosphate binding site [chemical binding]; other site
370438001632	catalytic residue [active]
370438001633	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
370438001634	acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118
370438001635	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
370438001636	PYR/PP interface [polypeptide binding]; other site
370438001637	dimer interface [polypeptide binding]; other site
370438001638	TPP binding site [chemical binding]; other site
370438001639	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
370438001640	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
370438001641	TPP-binding site [chemical binding]; other site
370438001642	dimer interface [polypeptide binding]; other site
370438001643	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
370438001644	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
370438001645	putative valine binding site [chemical binding]; other site
370438001646	dimer interface [polypeptide binding]; other site
370438001647	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
370438001648	ketol-acid reductoisomerase; Provisional; Region: PRK05479
370438001649	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
370438001650	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
370438001651	acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048
370438001652	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
370438001653	PYR/PP interface [polypeptide binding]; other site
370438001654	dimer interface [polypeptide binding]; other site
370438001655	TPP binding site [chemical binding]; other site
370438001656	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
370438001657	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
370438001658	TPP-binding site [chemical binding]; other site
370438001659	dimer interface [polypeptide binding]; other site
370438001660	2-isopropylmalate synthase; Validated; Region: PRK00915
370438001661	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
370438001662	active site
370438001663	catalytic residues [active]
370438001664	metal binding site [ion binding]; metal-binding site
370438001665	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
370438001666	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
370438001667	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
370438001668	substrate binding site [chemical binding]; other site
370438001669	ligand binding site [chemical binding]; other site
370438001670	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
370438001671	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
370438001672	substrate binding site [chemical binding]; other site
370438001673	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
370438001674	tartrate dehydrogenase; Region: TTC; TIGR02089
370438001675	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
370438001676	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
370438001677	active site
370438001678	catalytic residues [active]
370438001679	metal binding site [ion binding]; metal-binding site
370438001680	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
370438001681	Uncharacterized conserved protein [Function unknown]; Region: COG1624
370438001682	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
370438001683	YbbR-like protein; Region: YbbR; pfam07949
370438001684	YbbR-like protein; Region: YbbR; pfam07949
370438001685	YbbR-like protein; Region: YbbR; pfam07949
370438001686	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
370438001687	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
370438001688	active site
370438001689	substrate binding site [chemical binding]; other site
370438001690	metal binding site [ion binding]; metal-binding site
370438001691	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
370438001692	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
370438001693	glutaminase active site [active]
370438001694	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
370438001695	dimer interface [polypeptide binding]; other site
370438001696	active site
370438001697	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
370438001698	dimer interface [polypeptide binding]; other site
370438001699	active site
370438001700	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; cl09153
370438001701	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
370438001702	Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296
370438001703	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
370438001704	Predicted permease; Region: DUF318; cl17795
370438001705	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
370438001706	dimerization interface [polypeptide binding]; other site
370438001707	putative DNA binding site [nucleotide binding]; other site
370438001708	putative Zn2+ binding site [ion binding]; other site
370438001709	PAS domain; Region: PAS_9; pfam13426
370438001710	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
370438001711	GAF domain; Region: GAF; pfam01590
370438001712	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
370438001713	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
370438001714	metal binding site [ion binding]; metal-binding site
370438001715	active site
370438001716	I-site; other site
370438001717	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
370438001718	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
370438001719	Zn2+ binding site [ion binding]; other site
370438001720	Mg2+ binding site [ion binding]; other site
370438001721	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438001722	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
370438001723	Walker A motif; other site
370438001724	ATP binding site [chemical binding]; other site
370438001725	Walker B motif; other site
370438001726	arginine finger; other site
370438001727	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
370438001728	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
370438001729	metal ion-dependent adhesion site (MIDAS); other site
370438001730	Uncharacterized ArCR, COG2043; Region: DUF169; pfam02596
370438001731	SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain.  The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY,  and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421
370438001732	CPxP  motif; other site
370438001733	putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112
370438001734	TOBE domain; Region: TOBE; cl01440
370438001735	Flagellin N-methylase; Region: FliB; pfam03692
370438001736	Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818
370438001737	geranylgeranyl reductase family; Region: GG-red-SF; TIGR02032
370438001738	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
370438001739	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
370438001740	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
370438001741	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
370438001742	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
370438001743	Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788
370438001744	alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400
370438001745	active site
370438001746	homotetramer interface [polypeptide binding]; other site
370438001747	Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877
370438001748	trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105
370438001749	Putative amidase domain; Region: Amidase_6; pfam12671
370438001750	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
370438001751	active site
370438001752	Protein of unknown function (DUF2512); Region: DUF2512; pfam10710
370438001753	Uncharacterized conserved protein [Function unknown]; Region: COG0432
370438001754	Protein of unknown function (DUF3006); Region: DUF3006; pfam11213
370438001755	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
370438001756	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
370438001757	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
370438001758	Predicted permease; Region: DUF318; cl17795
370438001759	NMT1-like family; Region: NMT1_2; pfam13379
370438001760	NMT1/THI5 like; Region: NMT1; pfam09084
370438001761	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
370438001762	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
370438001763	dimer interface [polypeptide binding]; other site
370438001764	conserved gate region; other site
370438001765	ABC-ATPase subunit interface; other site
370438001766	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
370438001767	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
370438001768	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
370438001769	Walker A/P-loop; other site
370438001770	ATP binding site [chemical binding]; other site
370438001771	Q-loop/lid; other site
370438001772	ABC transporter signature motif; other site
370438001773	Walker B; other site
370438001774	D-loop; other site
370438001775	H-loop/switch region; other site
370438001776	DsrE/DsrF-like family; Region: DrsE; pfam02635
370438001777	benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263
370438001778	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
370438001779	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
370438001780	The MopB_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. Members...; Region: MopB_Acetylene-hydratase; cd02759
370438001781	putative [Fe4-S4] binding site [ion binding]; other site
370438001782	putative molybdopterin cofactor binding site [chemical binding]; other site
370438001783	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
370438001784	molybdopterin cofactor binding site; other site
370438001785	MOSC domain; Region: MOSC; pfam03473
370438001786	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
370438001787	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
370438001788	trimerization site [polypeptide binding]; other site
370438001789	active site
370438001790	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
370438001791	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
370438001792	This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110
370438001793	switch II; other site
370438001794	MinD superfamily P-loop ATPase containing an inserted ferredoxin domain [Energy production and conversion]; Region: COG1149
370438001795	This protein family's function is unkown. It contains nucleotide binding site. It uses NTP as energy source to transfer electron or ion; Region: Fer4_NifH_child; cd03110
370438001796	P loop nucleotide binding; other site
370438001797	switch II; other site
370438001798	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
370438001799	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489
370438001800	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
370438001801	Walker A motif; other site
370438001802	Predicted DNA-binding proteins [General function prediction only]; Region: COG1342
370438001803	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
370438001804	DNA binding residues [nucleotide binding]
370438001805	mycofactocin precursor; Region: mycofactocin; TIGR03969
370438001806	oxidoreductase, SDR family; Region: SDR_subfam_1; TIGR03971
370438001807	classical (c) SDRs; Region: SDR_c; cd05233
370438001808	NAD(P) binding site [chemical binding]; other site
370438001809	active site
370438001810	putative mycofactocin binding protein MftB; Region: mycofact_MftB; TIGR03967
370438001811	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
370438001812	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370438001813	FeS/SAM binding site; other site
370438001814	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
370438001815	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
370438001816	Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734
370438001817	putative active site [active]
370438001818	putative FMN binding site [chemical binding]; other site
370438001819	putative substrate binding site [chemical binding]; other site
370438001820	putative catalytic residue [active]
370438001821	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
370438001822	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
370438001823	Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734
370438001824	putative active site [active]
370438001825	putative FMN binding site [chemical binding]; other site
370438001826	putative substrate binding site [chemical binding]; other site
370438001827	putative catalytic residue [active]
370438001828	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
370438001829	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
370438001830	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
370438001831	oxidoreductase; Provisional; Region: PRK10015
370438001832	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
370438001833	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
370438001834	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
370438001835	Ligand Binding Site [chemical binding]; other site
370438001836	Electron transfer flavoprotein domain; Region: ETF; pfam01012
370438001837	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
370438001838	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
370438001839	active site
370438001840	PBP superfamily domain; Region: PBP_like_2; pfam12849
370438001841	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
370438001842	PBP superfamily domain; Region: PBP_like_2; pfam12849
370438001843	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
370438001844	Thiamine pyrophosphokinase; Region: TPK; cd07995
370438001845	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
370438001846	active site
370438001847	dimerization interface [polypeptide binding]; other site
370438001848	thiamine binding site [chemical binding]; other site
370438001849	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
370438001850	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370438001851	active site
370438001852	phosphorylation site [posttranslational modification]
370438001853	intermolecular recognition site; other site
370438001854	dimerization interface [polypeptide binding]; other site
370438001855	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438001856	Walker A motif; other site
370438001857	ATP binding site [chemical binding]; other site
370438001858	Walker B motif; other site
370438001859	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
370438001860	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
370438001861	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
370438001862	dimer interface [polypeptide binding]; other site
370438001863	active site
370438001864	metal binding site [ion binding]; metal-binding site
370438001865	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
370438001866	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
370438001867	Zn2+ binding site [ion binding]; other site
370438001868	Mg2+ binding site [ion binding]; other site
370438001869	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
370438001870	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
370438001871	pyridoxal 5'-phosphate binding site [chemical binding]; other site
370438001872	catalytic residue [active]
370438001873	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
370438001874	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
370438001875	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
370438001876	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
370438001877	Ubiquitin-like proteins; Region: UBQ; cl00155
370438001878	charged pocket; other site
370438001879	hydrophobic patch; other site
370438001880	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476
370438001881	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
370438001882	ATP binding site [chemical binding]; other site
370438001883	substrate interface [chemical binding]; other site
370438001884	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
370438001885	Beta propeller domain; Region: Beta_propel; pfam09826
370438001886	S-layer homology domain; Region: SLH; pfam00395
370438001887	S-layer homology domain; Region: SLH; pfam00395
370438001888	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195
370438001889	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
370438001890	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370438001891	FeS/SAM binding site; other site
370438001892	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
370438001893	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
370438001894	D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449
370438001895	putative ADP-binding pocket [chemical binding]; other site
370438001896	Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116
370438001897	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
370438001898	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
370438001899	Mechanosensitive ion channel; Region: MS_channel; pfam00924
370438001900	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
370438001901	Dynamin family; Region: Dynamin_N; pfam00350
370438001902	G1 box; other site
370438001903	GTP/Mg2+ binding site [chemical binding]; other site
370438001904	G2 box; other site
370438001905	Switch I region; other site
370438001906	G3 box; other site
370438001907	Switch II region; other site
370438001908	G4 box; other site
370438001909	G5 box; other site
370438001910	Flagellin N-methylase; Region: FliB; pfam03692
370438001911	Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907
370438001912	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
370438001913	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
370438001914	active site
370438001915	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
370438001916	L-iditol 2-dehydrogenase; Region: iditol_2_DH_like; cd08235
370438001917	putative NAD(P) binding site [chemical binding]; other site
370438001918	catalytic Zn binding site [ion binding]; other site
370438001919	DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830
370438001920	Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958
370438001921	putative active site; other site
370438001922	catalytic residue [active]
370438001923	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
370438001924	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
370438001925	Major Facilitator Superfamily; Region: MFS_1; pfam07690
370438001926	putative substrate translocation pore; other site
370438001927	Ferritin-like domain; Region: Ferritin; pfam00210
370438001928	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
370438001929	dinuclear metal binding motif [ion binding]; other site
370438001930	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
370438001931	This domain family includes the alpha-crystallin domain (ACD) of alpha-crystallin-type small heat shock proteins (sHsps) and a similar domain found in p23-like proteins.  sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa; Region: ACD_sHsps_p23-like; cd00298
370438001932	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
370438001933	dimer interface [polypeptide binding]; other site
370438001934	putative CheW interface [polypeptide binding]; other site
370438001935	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723
370438001936	stage V sporulation protein T; Region: spore_V_T; TIGR02851
370438001937	looped-hinge helix DNA binding domain, AbrB family; Region: lp_hng_hel_AbrB; TIGR01439
370438001938	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
370438001939	thiS-thiF/thiG interaction site; other site
370438001940	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
370438001941	ThiS interaction site; other site
370438001942	putative active site [active]
370438001943	tetramer interface [polypeptide binding]; other site
370438001944	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
370438001945	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370438001946	FeS/SAM binding site; other site
370438001947	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
370438001948	thiamine biosynthesis protein ThiF; Provisional; Region: PRK08644
370438001949	E1_ThiF_like. Member of superfamily of activating enzymes (E1) of the ubiquitin-like proteins. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like substrate, on...; Region: E1_ThiF_like; cd01487
370438001950	putative ATP binding site [chemical binding]; other site
370438001951	putative substrate interface [chemical binding]; other site
370438001952	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
370438001953	thiamine phosphate binding site [chemical binding]; other site
370438001954	active site
370438001955	pyrophosphate binding site [ion binding]; other site
370438001956	thiamine biosynthesis protein ThiC; Provisional; Region: PRK13352
370438001957	thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190
370438001958	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
370438001959	Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908
370438001960	putative ADP-ribose binding site [chemical binding]; other site
370438001961	putative active site [active]
370438001962	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
370438001963	dimerization interface [polypeptide binding]; other site
370438001964	putative DNA binding site [nucleotide binding]; other site
370438001965	putative Zn2+ binding site [ion binding]; other site
370438001966	Predicted permease; Region: DUF318; cl17795
370438001967	DGC domain; Region: DGC; pfam08859
370438001968	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
370438001969	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
370438001970	dimerization interface [polypeptide binding]; other site
370438001971	putative DNA binding site [nucleotide binding]; other site
370438001972	putative Zn2+ binding site [ion binding]; other site
370438001973	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
370438001974	arsenical-resistance protein; Region: acr3; TIGR00832
370438001975	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
370438001976	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
370438001977	GAF domain; Region: GAF; pfam01590
370438001978	Histidine kinase; Region: His_kinase; pfam06580
370438001979	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
370438001980	ATP binding site [chemical binding]; other site
370438001981	Mg2+ binding site [ion binding]; other site
370438001982	G-X-G motif; other site
370438001983	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
370438001984	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370438001985	active site
370438001986	phosphorylation site [posttranslational modification]
370438001987	intermolecular recognition site; other site
370438001988	dimerization interface [polypeptide binding]; other site
370438001989	LytTr DNA-binding domain; Region: LytTR; smart00850
370438001990	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
370438001991	Uncharacterized conserved protein [Function unknown]; Region: COG0062
370438001992	putative carbohydrate kinase; Provisional; Region: PRK10565
370438001993	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
370438001994	putative substrate binding site [chemical binding]; other site
370438001995	putative ATP binding site [chemical binding]; other site
370438001996	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
370438001997	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
370438001998	hexamer interface [polypeptide binding]; other site
370438001999	ligand binding site [chemical binding]; other site
370438002000	putative active site [active]
370438002001	NAD(P) binding site [chemical binding]; other site
370438002002	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
370438002003	alanine racemase; Reviewed; Region: alr; PRK00053
370438002004	active site
370438002005	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
370438002006	dimer interface [polypeptide binding]; other site
370438002007	substrate binding site [chemical binding]; other site
370438002008	catalytic residues [active]
370438002009	Protein of unknown function DUF89; Region: DUF89; cl15397
370438002010	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
370438002011	FMN binding site [chemical binding]; other site
370438002012	dimer interface [polypeptide binding]; other site
370438002013	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
370438002014	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
370438002015	Nitrogen regulatory protein P-II; Region: P-II; smart00938
370438002016	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
370438002017	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
370438002018	dimer interface [polypeptide binding]; other site
370438002019	putative CheW interface [polypeptide binding]; other site
370438002020	Cache domain; Region: Cache_1; pfam02743
370438002021	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
370438002022	4Fe-4S binding domain; Region: Fer4; pfam00037
370438002023	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
370438002024	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
370438002025	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
370438002026	4Fe-4S binding domain; Region: Fer4; pfam00037
370438002027	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
370438002028	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
370438002029	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
370438002030	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
370438002031	DNA binding residues [nucleotide binding]
370438002032	Putative zinc-finger; Region: zf-HC2; pfam13490
370438002033	Domain of unknown function (DUF4367); Region: DUF4367; pfam14285
370438002034	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
370438002035	active site
370438002036	asparagine synthase (glutamine-hydrolyzing); Region: asn_synth_AEB; TIGR01536
370438002037	dimer interface [polypeptide binding]; other site
370438002038	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
370438002039	Ligand Binding Site [chemical binding]; other site
370438002040	Molecular Tunnel; other site
370438002041	Helix-turn-helix domain; Region: HTH_17; pfam12728
370438002042	PBP superfamily domain; Region: PBP_like; pfam12727
370438002043	molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677
370438002044	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
370438002045	membrane-bound complex binding site; other site
370438002046	hinge residues; other site
370438002047	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
370438002048	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
370438002049	dimer interface [polypeptide binding]; other site
370438002050	conserved gate region; other site
370438002051	putative PBP binding loops; other site
370438002052	ABC-ATPase subunit interface; other site
370438002053	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
370438002054	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
370438002055	Walker A/P-loop; other site
370438002056	ATP binding site [chemical binding]; other site
370438002057	Q-loop/lid; other site
370438002058	ABC transporter signature motif; other site
370438002059	Walker B; other site
370438002060	D-loop; other site
370438002061	H-loop/switch region; other site
370438002062	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
370438002063	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370438002064	active site
370438002065	phosphorylation site [posttranslational modification]
370438002066	intermolecular recognition site; other site
370438002067	dimerization interface [polypeptide binding]; other site
370438002068	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438002069	Walker A motif; other site
370438002070	ATP binding site [chemical binding]; other site
370438002071	Walker B motif; other site
370438002072	arginine finger; other site
370438002073	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
370438002074	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
370438002075	selenium-dependent molybdenum hydroxylase 1; Region: Se_dep_Molyb_1; TIGR03311
370438002076	catalytic loop [active]
370438002077	iron binding site [ion binding]; other site
370438002078	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
370438002079	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
370438002080	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
370438002081	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
370438002082	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
370438002083	Cysteine-rich domain; Region: CCG; pfam02754
370438002084	LIM is a small protein-protein interaction domain, containing two zinc fingers; Region: LIM; cl02475
370438002085	Zn binding site [ion binding]; other site
370438002086	Methyltransferase domain; Region: Methyltransf_23; pfam13489
370438002087	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
370438002088	S-adenosylmethionine binding site [chemical binding]; other site
370438002089	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719
370438002090	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964
370438002091	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370438002092	FeS/SAM binding site; other site
370438002093	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
370438002094	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
370438002095	acyl-activating enzyme (AAE) consensus motif; other site
370438002096	active site
370438002097	AMP binding site [chemical binding]; other site
370438002098	CoA binding site [chemical binding]; other site
370438002099	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
370438002100	XdhC Rossmann domain; Region: XdhC_C; pfam13478
370438002101	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
370438002102	metal-binding site
370438002103	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
370438002104	putative MPT binding site; other site
370438002105	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
370438002106	catalytic core [active]
370438002107	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
370438002108	Cysteine-rich domain; Region: CCG; pfam02754
370438002109	hypothetical protein; Provisional; Region: PRK06851
370438002110	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
370438002111	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
370438002112	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
370438002113	catalytic residues [active]
370438002114	catalytic nucleophile [active]
370438002115	Recombinase; Region: Recombinase; pfam07508
370438002116	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
370438002117	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2405
370438002118	Domain of unknown function (DUF3368); Region: DUF3368; pfam11848
370438002119	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
370438002120	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
370438002121	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
370438002122	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
370438002123	HTH domain; Region: HTH_11; pfam08279
370438002124	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
370438002125	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
370438002126	SpoVT / AbrB like domain; Region: SpoVT_AbrB; smart00966
370438002127	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
370438002128	putative active site [active]
370438002129	Protein of unknown function (DUF433); Region: DUF433; pfam04255
370438002130	CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436
370438002131	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
370438002132	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09701
370438002133	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
370438002134	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
370438002135	Transposase; Region: DEDD_Tnp_IS110; pfam01548
370438002136	CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cl17440
370438002137	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
370438002138	DNA methylase; Region: N6_N4_Mtase; cl17433
370438002139	DNA methylase; Region: N6_N4_Mtase; cl17433
370438002140	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
370438002141	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
370438002142	ATP binding site [chemical binding]; other site
370438002143	putative Mg++ binding site [ion binding]; other site
370438002144	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
370438002145	nucleotide binding region [chemical binding]; other site
370438002146	ATP-binding site [chemical binding]; other site
370438002147	PglZ domain; Region: PglZ; pfam08665
370438002148	HTH-like domain; Region: HTH_21; pfam13276
370438002149	Integrase core domain; Region: rve; pfam00665
370438002150	Integrase core domain; Region: rve_3; pfam13683
370438002151	Transposase, Mutator family; Region: Transposase_mut; pfam00872
370438002152	MULE transposase domain; Region: MULE; pfam10551
370438002153	Piwi_piwi-like_ProArk: PIWI domain, Piwi-like subfamily found in Archaea and Bacteria. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs; Region: Piwi_piwi-like_ProArk; cd04659
370438002154	5' RNA guide strand anchoring site; other site
370438002155	active site
370438002156	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
370438002157	putative active site [active]
370438002158	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
370438002159	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
370438002160	sequence-specific DNA binding site [nucleotide binding]; other site
370438002161	salt bridge; other site
370438002162	Domain of unknown function (DUF955); Region: DUF955; cl01076
370438002163	hypothetical protein; Provisional; Region: PRK06761
370438002164	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
370438002165	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370438002166	active site
370438002167	phosphorylation site [posttranslational modification]
370438002168	intermolecular recognition site; other site
370438002169	dimerization interface [polypeptide binding]; other site
370438002170	ANTAR domain; Region: ANTAR; pfam03861
370438002171	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
370438002172	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
370438002173	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
370438002174	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
370438002175	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
370438002176	active site
370438002177	FMN binding site [chemical binding]; other site
370438002178	substrate binding site [chemical binding]; other site
370438002179	3Fe-4S cluster binding site [ion binding]; other site
370438002180	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
370438002181	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370438002182	active site
370438002183	phosphorylation site [posttranslational modification]
370438002184	intermolecular recognition site; other site
370438002185	dimerization interface [polypeptide binding]; other site
370438002186	ANTAR domain; Region: ANTAR; pfam03861
370438002187	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
370438002188	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
370438002189	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
370438002190	glutamine synthetase, type I; Region: GlnA; TIGR00653
370438002191	glutamine synthetase, type I; Region: GlnA; TIGR00653
370438002192	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
370438002193	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
370438002194	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
370438002195	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
370438002196	active site
370438002197	dimer interface [polypeptide binding]; other site
370438002198	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
370438002199	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
370438002200	active site
370438002201	FMN binding site [chemical binding]; other site
370438002202	substrate binding site [chemical binding]; other site
370438002203	3Fe-4S cluster binding site [ion binding]; other site
370438002204	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
370438002205	domain interface; other site
370438002206	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
370438002207	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
370438002208	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
370438002209	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
370438002210	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
370438002211	putative valine binding site [chemical binding]; other site
370438002212	dimer interface [polypeptide binding]; other site
370438002213	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
370438002214	Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain and a metal-binding domain [Transcription]; Region: NikR; COG0864
370438002215	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
370438002216	PemK-like protein; Region: PemK; pfam02452
370438002217	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
370438002218	Amidohydrolase; Region: Amidohydro_5; pfam13594
370438002219	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
370438002220	active site
370438002221	Response regulator receiver domain; Region: Response_reg; pfam00072
370438002222	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370438002223	active site
370438002224	phosphorylation site [posttranslational modification]
370438002225	intermolecular recognition site; other site
370438002226	dimerization interface [polypeptide binding]; other site
370438002227	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
370438002228	Glycoprotease family; Region: Peptidase_M22; pfam00814
370438002229	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
370438002230	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
370438002231	Cell division protein FtsA; Region: FtsA; smart00842
370438002232	Cell division protein FtsA; Region: FtsA; pfam14450
370438002233	Protein of unknown function DUF72; Region: DUF72; pfam01904
370438002234	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
370438002235	L-lactate dehydrogenase; Reviewed; Region: ldh; PRK00066
370438002236	dimer interface [polypeptide binding]; other site
370438002237	NAD binding site [chemical binding]; other site
370438002238	substrate binding site [chemical binding]; other site
370438002239	tetramer (dimer of dimers) interface [polypeptide binding]; other site
370438002240	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
370438002241	KaiC; Region: KaiC; pfam06745
370438002242	Walker A motif; other site
370438002243	ATP binding site [chemical binding]; other site
370438002244	Walker B motif; other site
370438002245	KaiC; Region: KaiC; pfam06745
370438002246	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
370438002247	ATP binding site [chemical binding]; other site
370438002248	Walker B motif; other site
370438002249	RecA-superfamily ATPases implicated in signal transduction [Signal transduction mechanisms]; Region: RAD55; COG0467
370438002250	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
370438002251	Walker A motif; other site
370438002252	ATP binding site [chemical binding]; other site
370438002253	Walker B motif; other site
370438002254	The V4R (vinyl 4 reductase) domain is a predicted small molecular binding domain, that may bind to hydrocarbons; Region: V4R; smart00989
370438002255	PAS domain; Region: PAS; smart00091
370438002256	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
370438002257	putative active site [active]
370438002258	heme pocket [chemical binding]; other site
370438002259	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
370438002260	dimer interface [polypeptide binding]; other site
370438002261	phosphorylation site [posttranslational modification]
370438002262	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
370438002263	ATP binding site [chemical binding]; other site
370438002264	Mg2+ binding site [ion binding]; other site
370438002265	G-X-G motif; other site
370438002266	PemK-like protein; Region: PemK; cl00995
370438002267	Transposase domain (DUF772); Region: DUF772; pfam05598
370438002268	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
370438002269	DNA methylase; Region: N6_N4_Mtase; pfam01555
370438002270	Uncharacterized conserved protein (DUF2304); Region: DUF2304; cl01034
370438002271	PRC-barrel domain containing protein [General function prediction only]; Region: COG3881
370438002272	PRC-barrel domain; Region: PRC; pfam05239
370438002273	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
370438002274	VanW like protein; Region: VanW; pfam04294
370438002275	G5 domain; Region: G5; pfam07501
370438002276	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
370438002277	putative active site [active]
370438002278	PrcB C-terminal; Region: PrcB_C; pfam14343
370438002279	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
370438002280	S-layer homology domain; Region: SLH; pfam00395
370438002281	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
370438002282	structural tetrad; other site
370438002283	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
370438002284	putative substrate translocation pore; other site
370438002285	Major Facilitator Superfamily; Region: MFS_1; pfam07690
370438002286	RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2
370438002287	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
370438002288	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
370438002289	DNA binding residues [nucleotide binding]
370438002290	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
370438002291	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
370438002292	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
370438002293	Walker A/P-loop; other site
370438002294	ATP binding site [chemical binding]; other site
370438002295	Q-loop/lid; other site
370438002296	ABC transporter signature motif; other site
370438002297	Walker B; other site
370438002298	D-loop; other site
370438002299	H-loop/switch region; other site
370438002300	ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277
370438002301	Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282
370438002302	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
370438002303	ABC-2 type transporter; Region: ABC2_membrane; cl17235
370438002304	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
370438002305	daunorubicin resistance ABC transporter ATP-binding subunit; Region: drrA; TIGR01188
370438002306	Walker A/P-loop; other site
370438002307	ATP binding site [chemical binding]; other site
370438002308	Q-loop/lid; other site
370438002309	ABC transporter signature motif; other site
370438002310	Walker B; other site
370438002311	D-loop; other site
370438002312	H-loop/switch region; other site
370438002313	MarR family; Region: MarR_2; pfam12802
370438002314	hybrid cluster protein; Provisional; Region: PRK05290
370438002315	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
370438002316	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
370438002317	ACS interaction site; other site
370438002318	CODH interaction site; other site
370438002319	metal cluster binding site [ion binding]; other site
370438002320	Ferredoxin [Energy production and conversion]; Region: COG1146
370438002321	4Fe-4S binding domain; Region: Fer4_6; pfam12837
370438002322	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
370438002323	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
370438002324	ligand binding site [chemical binding]; other site
370438002325	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
370438002326	putative switch regulator; other site
370438002327	non-specific DNA interactions [nucleotide binding]; other site
370438002328	DNA binding site [nucleotide binding]
370438002329	sequence specific DNA binding site [nucleotide binding]; other site
370438002330	putative cAMP binding site [chemical binding]; other site
370438002331	SCP-2 sterol transfer family; Region: SCP2; pfam02036
370438002332	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
370438002333	Bacterial SH3 domain; Region: SH3_3; pfam08239
370438002334	Bacterial SH3 domain; Region: SH3_3; pfam08239
370438002335	Bacterial SH3 domain; Region: SH3_3; pfam08239
370438002336	AMIN domain; Region: AMIN; pfam11741
370438002337	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
370438002338	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
370438002339	active site
370438002340	metal binding site [ion binding]; metal-binding site
370438002341	glutamate racemase; Provisional; Region: PRK00865
370438002342	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
370438002343	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
370438002344	Metal-dependent hydrolases of the beta-lactamase superfamily III [General function prediction only]; Region: ElaC; COG1234
370438002345	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
370438002346	ribonuclease PH; Reviewed; Region: rph; PRK00173
370438002347	Ribonuclease PH; Region: RNase_PH_bact; cd11362
370438002348	hexamer interface [polypeptide binding]; other site
370438002349	active site
370438002350	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
370438002351	active site
370438002352	dimerization interface [polypeptide binding]; other site
370438002353	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
370438002354	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
370438002355	active site
370438002356	metal binding site [ion binding]; metal-binding site
370438002357	homotetramer interface [polypeptide binding]; other site
370438002358	enoyl-CoA hydratase; Provisional; Region: PRK06688
370438002359	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
370438002360	substrate binding site [chemical binding]; other site
370438002361	oxyanion hole (OAH) forming residues; other site
370438002362	trimer interface [polypeptide binding]; other site
370438002363	FHIT (fragile histidine family): FHIT proteins, related to the HIT family carry a motif HxHxH/Qxx (x, is a hydrophobic amino acid), On the basis of sequence, substrate specificity, structure, evolution and mechanism, HIT proteins are classified into...; Region: FHIT; cd01275
370438002364	nucleotide binding site/active site [active]
370438002365	HIT family signature motif; other site
370438002366	catalytic residue [active]
370438002367	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
370438002368	dimerization interface [polypeptide binding]; other site
370438002369	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
370438002370	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
370438002371	dimer interface [polypeptide binding]; other site
370438002372	putative CheW interface [polypeptide binding]; other site
370438002373	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
370438002374	non-specific DNA binding site [nucleotide binding]; other site
370438002375	salt bridge; other site
370438002376	sequence-specific DNA binding site [nucleotide binding]; other site
370438002377	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
370438002378	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
370438002379	Zn2+ binding site [ion binding]; other site
370438002380	Mg2+ binding site [ion binding]; other site
370438002381	FOG: CBS domain [General function prediction only]; Region: COG0517
370438002382	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the GGDEF (DiGuanylate-Cyclase (DGC)) domain. The GGDEF domain has been suggested to be homologous to the adenylyl cyclase catalytic domain and...; Region: CBS_pair_GGDEF_assoc2; cd04599
370438002383	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
370438002384	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
370438002385	metal binding site [ion binding]; metal-binding site
370438002386	active site
370438002387	I-site; other site
370438002388	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
370438002389	trigger factor; Provisional; Region: tig; PRK01490
370438002390	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
370438002391	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
370438002392	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
370438002393	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
370438002394	oligomer interface [polypeptide binding]; other site
370438002395	active site residues [active]
370438002396	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
370438002397	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
370438002398	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438002399	Walker A motif; other site
370438002400	ATP binding site [chemical binding]; other site
370438002401	Walker B motif; other site
370438002402	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
370438002403	ATP-dependent protease LonB; Region: spore_lonB; TIGR02902
370438002404	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438002405	Walker A motif; other site
370438002406	ATP binding site [chemical binding]; other site
370438002407	Walker B motif; other site
370438002408	arginine finger; other site
370438002409	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
370438002410	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
370438002411	Found in ATP-dependent protease La (LON); Region: LON; smart00464
370438002412	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438002413	Walker A motif; other site
370438002414	ATP binding site [chemical binding]; other site
370438002415	Walker B motif; other site
370438002416	arginine finger; other site
370438002417	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
370438002418	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
370438002419	G1 box; other site
370438002420	GTP/Mg2+ binding site [chemical binding]; other site
370438002421	Switch I region; other site
370438002422	G2 box; other site
370438002423	G3 box; other site
370438002424	Switch II region; other site
370438002425	G4 box; other site
370438002426	G5 box; other site
370438002427	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
370438002428	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
370438002429	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
370438002430	HIGH motif; other site
370438002431	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
370438002432	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
370438002433	active site
370438002434	KMSKS motif; other site
370438002435	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
370438002436	tRNA binding surface [nucleotide binding]; other site
370438002437	anticodon binding site; other site
370438002438	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
370438002439	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
370438002440	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
370438002441	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
370438002442	Domain of unknown function (DUF4321); Region: DUF4321; pfam14209
370438002443	Maf-like protein; Region: Maf; pfam02545
370438002444	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
370438002445	active site
370438002446	dimer interface [polypeptide binding]; other site
370438002447	hypothetical protein; Reviewed; Region: PRK00024
370438002448	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
370438002449	MPN+ (JAMM) motif; other site
370438002450	Zinc-binding site [ion binding]; other site
370438002451	rod shape-determining protein MreB; Provisional; Region: PRK13927
370438002452	MreB and similar proteins; Region: MreB_like; cd10225
370438002453	nucleotide binding site [chemical binding]; other site
370438002454	Mg binding site [ion binding]; other site
370438002455	putative protofilament interaction site [polypeptide binding]; other site
370438002456	RodZ interaction site [polypeptide binding]; other site
370438002457	rod shape-determining protein MreC; Provisional; Region: PRK13922
370438002458	rod shape-determining protein MreC; Region: MreC; pfam04085
370438002459	rod shape-determining protein MreD; Region: shape_MreD; TIGR03426
370438002460	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
370438002461	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
370438002462	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
370438002463	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
370438002464	septum site-determining protein MinD; Region: minD_bact; TIGR01968
370438002465	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
370438002466	Switch I; other site
370438002467	Switch II; other site
370438002468	Septum formation topological specificity factor MinE; Region: MinE; cl00538
370438002469	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
370438002470	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
370438002471	Peptidase family M23; Region: Peptidase_M23; pfam01551
370438002472	SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. SpoIVFB (sporulation protein, stage IV cell wall formation, F...; Region: S2P-M50_SpoIVFB; cd06161
370438002473	Peptidase family M50; Region: Peptidase_M50; pfam02163
370438002474	putative substrate binding region [chemical binding]; other site
370438002475	radical SAM family uncharacterized protein; Region: rSAM_fuse_unch; TIGR03960
370438002476	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
370438002477	B12 binding site [chemical binding]; other site
370438002478	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370438002479	FeS/SAM binding site; other site
370438002480	radical SAM-linked protein; Region: sam_1_link_chp; TIGR03936
370438002481	Uncharacterized protein conserved in bacteria (DUF2344); Region: DUF2344; pfam10105
370438002482	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
370438002483	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
370438002484	homodimer interface [polypeptide binding]; other site
370438002485	oligonucleotide binding site [chemical binding]; other site
370438002486	TRAM domain; Region: TRAM; cl01282
370438002487	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
370438002488	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
370438002489	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
370438002490	GTPase CgtA; Reviewed; Region: obgE; PRK12297
370438002491	GTP1/OBG; Region: GTP1_OBG; pfam01018
370438002492	Obg GTPase; Region: Obg; cd01898
370438002493	G1 box; other site
370438002494	GTP/Mg2+ binding site [chemical binding]; other site
370438002495	Switch I region; other site
370438002496	G2 box; other site
370438002497	G3 box; other site
370438002498	Switch II region; other site
370438002499	G4 box; other site
370438002500	G5 box; other site
370438002501	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
370438002502	gamma-glutamyl kinase; Provisional; Region: PRK05429
370438002503	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
370438002504	nucleotide binding site [chemical binding]; other site
370438002505	homotetrameric interface [polypeptide binding]; other site
370438002506	putative phosphate binding site [ion binding]; other site
370438002507	putative allosteric binding site; other site
370438002508	PUA domain; Region: PUA; pfam01472
370438002509	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
370438002510	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
370438002511	active site
370438002512	(T/H)XGH motif; other site
370438002513	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
370438002514	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
370438002515	AMP-binding domain protein; Validated; Region: PRK08315
370438002516	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
370438002517	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
370438002518	acyl-activating enzyme (AAE) consensus motif; other site
370438002519	putative AMP binding site [chemical binding]; other site
370438002520	putative active site [active]
370438002521	putative CoA binding site [chemical binding]; other site
370438002522	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
370438002523	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
370438002524	HIGH motif; other site
370438002525	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
370438002526	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
370438002527	active site
370438002528	KMSKS motif; other site
370438002529	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
370438002530	tRNA binding surface [nucleotide binding]; other site
370438002531	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; cl17549
370438002532	Transcriptional regulator [Transcription]; Region: LysR; COG0583
370438002533	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
370438002534	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
370438002535	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
370438002536	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
370438002537	dimer interface [polypeptide binding]; other site
370438002538	conserved gate region; other site
370438002539	putative PBP binding loops; other site
370438002540	ABC-ATPase subunit interface; other site
370438002541	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
370438002542	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
370438002543	Walker A/P-loop; other site
370438002544	ATP binding site [chemical binding]; other site
370438002545	Q-loop/lid; other site
370438002546	ABC transporter signature motif; other site
370438002547	Walker B; other site
370438002548	D-loop; other site
370438002549	H-loop/switch region; other site
370438002550	Transcriptional regulator of aromatic amino acids metabolism [Transcription / Amino acid transport and metabolism]; Region: TyrR; COG3283
370438002551	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
370438002552	putative active site [active]
370438002553	heme pocket [chemical binding]; other site
370438002554	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438002555	Walker A motif; other site
370438002556	ATP binding site [chemical binding]; other site
370438002557	Walker B motif; other site
370438002558	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
370438002559	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; cl00546
370438002560	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778
370438002561	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
370438002562	TPP-binding site [chemical binding]; other site
370438002563	2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659
370438002564	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
370438002565	PYR/PP interface [polypeptide binding]; other site
370438002566	TPP binding site [chemical binding]; other site
370438002567	dimer interface [polypeptide binding]; other site
370438002568	substrate binding site [chemical binding]; other site
370438002569	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
370438002570	Ferredoxin [Energy production and conversion]; Region: COG1146
370438002571	Predicted membrane protein [Function unknown]; Region: COG2323
370438002572	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
370438002573	PAS domain; Region: PAS_9; pfam13426
370438002574	putative active site [active]
370438002575	heme pocket [chemical binding]; other site
370438002576	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438002577	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
370438002578	Walker A motif; other site
370438002579	ATP binding site [chemical binding]; other site
370438002580	Walker B motif; other site
370438002581	arginine finger; other site
370438002582	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
370438002583	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
370438002584	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
370438002585	putative active site [active]
370438002586	metal binding site [ion binding]; metal-binding site
370438002587	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
370438002588	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
370438002589	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
370438002590	Permease family; Region: Xan_ur_permease; pfam00860
370438002591	SLBB domain; Region: SLBB; pfam10531
370438002592	comEA protein; Region: comE; TIGR01259
370438002593	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
370438002594	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
370438002595	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
370438002596	N-acetyl-D-glucosamine binding site [chemical binding]; other site
370438002597	catalytic residue [active]
370438002598	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
370438002599	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
370438002600	Competence protein; Region: Competence; pfam03772
370438002601	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
370438002602	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
370438002603	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
370438002604	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
370438002605	ATP binding site [chemical binding]; other site
370438002606	putative Mg++ binding site [ion binding]; other site
370438002607	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
370438002608	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
370438002609	nucleotide binding region [chemical binding]; other site
370438002610	ATP-binding site [chemical binding]; other site
370438002611	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
370438002612	Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743
370438002613	Mrr N-terminal domain; Region: Mrr_N; pfam14338
370438002614	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483
370438002615	Protein of unknown function (DUF499); Region: DUF499; pfam04465
370438002616	chloroplast protein import component, Tic20 family; Region: 3a0901s05TIC20; TIGR00994
370438002617	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
370438002618	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
370438002619	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
370438002620	Domain of unknown function DUF77; Region: DUF77; pfam01910
370438002621	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
370438002622	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
370438002623	putative uracil/xanthine transporter; Provisional; Region: PRK11412
370438002624	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
370438002625	Membrane protein of unknown function; Region: DUF360; pfam04020
370438002626	Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454
370438002627	stage II sporulation protein P; Region: spore_II_P; TIGR02867
370438002628	GTP-binding protein LepA; Provisional; Region: PRK05433
370438002629	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
370438002630	G1 box; other site
370438002631	putative GEF interaction site [polypeptide binding]; other site
370438002632	GTP/Mg2+ binding site [chemical binding]; other site
370438002633	Switch I region; other site
370438002634	G2 box; other site
370438002635	G3 box; other site
370438002636	Switch II region; other site
370438002637	G4 box; other site
370438002638	G5 box; other site
370438002639	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
370438002640	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
370438002641	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
370438002642	coproporphyrinogen III oxidase; Provisional; Region: PRK05799
370438002643	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370438002644	FeS/SAM binding site; other site
370438002645	HemN C-terminal domain; Region: HemN_C; pfam06969
370438002646	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
370438002647	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
370438002648	chaperonin families, type I and type II. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. There are 2 main chaperonin groups. The...; Region: chaperonin_type_I_II; cd00309
370438002649	thermosome, various subunits, archaeal; Region: thermosome_arch; TIGR02339
370438002650	ATP/Mg binding site [chemical binding]; other site
370438002651	ring oligomerisation interface [polypeptide binding]; other site
370438002652	hinge regions; other site
370438002653	stacking interactions; other site
370438002654	Region: GrpE; pfam01025
370438002655	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
370438002656	dimer interface [polypeptide binding]; other site
370438002657	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
370438002658	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
370438002659	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
370438002660	nucleotide binding site [chemical binding]; other site
370438002661	NEF interaction site [polypeptide binding]; other site
370438002662	SBD interface [polypeptide binding]; other site
370438002663	chaperone protein DnaJ; Provisional; Region: PRK10767
370438002664	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
370438002665	HSP70 interaction site [polypeptide binding]; other site
370438002666	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
370438002667	substrate binding site [polypeptide binding]; other site
370438002668	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
370438002669	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
370438002670	dimer interface [polypeptide binding]; other site
370438002671	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
370438002672	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
370438002673	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
370438002674	RNA methyltransferase, RsmE family; Region: TIGR00046
370438002675	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
370438002676	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
370438002677	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
370438002678	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
370438002679	nucleotide binding site/active site [active]
370438002680	HIT family signature motif; other site
370438002681	catalytic residue [active]
370438002682	radical SAM peptide maturase, CXXX-repeat target family; Region: rSAM_Cxxx_rpt; TIGR04115
370438002683	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370438002684	FeS/SAM binding site; other site
370438002685	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
370438002686	Sm and related proteins; Region: Sm_like; cl00259
370438002687	heptamer interface [polypeptide binding]; other site
370438002688	Sm1 motif; other site
370438002689	hexamer interface [polypeptide binding]; other site
370438002690	RNA binding site [nucleotide binding]; other site
370438002691	Sm2 motif; other site
370438002692	YabP family; Region: YabP; cl06766
370438002693	sporulation protein YqfD; Region: spore_yqfD; TIGR02876
370438002694	Putative stage IV sporulation protein YqfD; Region: YqfD; pfam06898
370438002695	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
370438002696	PhoH-like protein; Region: PhoH; pfam02562
370438002697	7TM-HD extracellular; Region: 7TMR-HDED; pfam07697
370438002698	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
370438002699	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
370438002700	Zn2+ binding site [ion binding]; other site
370438002701	Mg2+ binding site [ion binding]; other site
370438002702	metal-binding heat shock protein; Provisional; Region: PRK00016
370438002703	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
370438002704	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
370438002705	active site
370438002706	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
370438002707	active site
370438002708	catalytic motif [active]
370438002709	Zn binding site [ion binding]; other site
370438002710	GTPase Era; Reviewed; Region: era; PRK00089
370438002711	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
370438002712	G1 box; other site
370438002713	GTP/Mg2+ binding site [chemical binding]; other site
370438002714	Switch I region; other site
370438002715	G2 box; other site
370438002716	Switch II region; other site
370438002717	G3 box; other site
370438002718	G4 box; other site
370438002719	G5 box; other site
370438002720	KH domain; Region: KH_2; pfam07650
370438002721	3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163
370438002722	Flavoprotein; Region: Flavoprotein; pfam02441
370438002723	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
370438002724	Recombination protein O N terminal; Region: RecO_N; pfam11967
370438002725	Recombination protein O C terminal; Region: RecO_C; pfam02565
370438002726	Domain of unknown function (DUF4342); Region: DUF4342; pfam14242
370438002727	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
370438002728	dimer interface [polypeptide binding]; other site
370438002729	motif 1; other site
370438002730	active site
370438002731	motif 2; other site
370438002732	motif 3; other site
370438002733	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
370438002734	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
370438002735	HTH domain; Region: HTH_11; pfam08279
370438002736	FOG: CBS domain [General function prediction only]; Region: COG0517
370438002737	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_4; cd04617
370438002738	Kinase/pyrophosphorylase; Region: Kinase-PPPase; pfam03618
370438002739	pyruvate phosphate dikinase; Provisional; Region: PRK09279
370438002740	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
370438002741	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
370438002742	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
370438002743	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
370438002744	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
370438002745	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
370438002746	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
370438002747	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
370438002748	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
370438002749	Zn2+ binding site [ion binding]; other site
370438002750	Mg2+ binding site [ion binding]; other site
370438002751	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
370438002752	DNA primase; Validated; Region: dnaG; PRK05667
370438002753	CHC2 zinc finger; Region: zf-CHC2; pfam01807
370438002754	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
370438002755	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
370438002756	active site
370438002757	metal binding site [ion binding]; metal-binding site
370438002758	interdomain interaction site; other site
370438002759	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
370438002760	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
370438002761	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
370438002762	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
370438002763	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
370438002764	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
370438002765	DNA binding residues [nucleotide binding]
370438002766	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
370438002767	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
370438002768	glutamine synthetase, type I; Region: GlnA; TIGR00653
370438002769	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
370438002770	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
370438002771	Family of unknown function (DUF633); Region: DUF633; pfam04816
370438002772	Uncharacterized conserved protein [Function unknown]; Region: COG0327
370438002773	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
370438002774	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323
370438002775	Uncharacterized conserved protein [Function unknown]; Region: COG0327
370438002776	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
370438002777	Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579
370438002778	Putative zinc ribbon domain; Region: DUF164; pfam02591
370438002779	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
370438002780	Histone deacetylase domain; Region: Hist_deacetyl; pfam00850
370438002781	active site
370438002782	metal binding site [ion binding]; metal-binding site
370438002783	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
370438002784	nudix motif; other site
370438002785	NAD synthetase; Provisional; Region: PRK13981
370438002786	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
370438002787	multimer interface [polypeptide binding]; other site
370438002788	active site
370438002789	catalytic triad [active]
370438002790	protein interface 1 [polypeptide binding]; other site
370438002791	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
370438002792	Ligand Binding Site [chemical binding]; other site
370438002793	L-fuculose phosphate aldolase; Provisional; Region: PRK08660
370438002794	intersubunit interface [polypeptide binding]; other site
370438002795	active site
370438002796	Zn2+ binding site [ion binding]; other site
370438002797	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
370438002798	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
370438002799	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
370438002800	glutamate racemase; Provisional; Region: PRK00865
370438002801	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u2; cd10926
370438002802	putative active site [active]
370438002803	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
370438002804	dimer interface [polypeptide binding]; other site
370438002805	substrate binding site [chemical binding]; other site
370438002806	ATP binding site [chemical binding]; other site
370438002807	haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702
370438002808	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
370438002809	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
370438002810	motif II; other site
370438002811	GTP-binding protein YchF; Reviewed; Region: PRK09601
370438002812	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
370438002813	G1 box; other site
370438002814	GTP/Mg2+ binding site [chemical binding]; other site
370438002815	G2 box; other site
370438002816	Switch I region; other site
370438002817	G3 box; other site
370438002818	Switch II region; other site
370438002819	G4 box; other site
370438002820	G5 box; other site
370438002821	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
370438002822	Uncharacterized Fe-S protein PflX, homolog of pyruvate formate lyase activating proteins [General function prediction only]; Region: PflX; COG1313
370438002823	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
370438002824	S-layer homology domain; Region: SLH; pfam00395
370438002825	S-layer homology domain; Region: SLH; pfam00395
370438002826	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
370438002827	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
370438002828	putative dimer interface [polypeptide binding]; other site
370438002829	active site pocket [active]
370438002830	putative cataytic base [active]
370438002831	Fructose-1,6-bisphosphatase; Region: FBPase_3; pfam01950
370438002832	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
370438002833	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
370438002834	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
370438002835	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
370438002836	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
370438002837	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
370438002838	YcfA-like protein; Region: YcfA; pfam07927
370438002839	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
370438002840	Protein export membrane protein; Region: SecD_SecF; cl14618
370438002841	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
370438002842	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
370438002843	peptide binding site [polypeptide binding]; other site
370438002844	Endonuclease IV [DNA replication, recombination, and repair]; Region: Nfo; COG0648
370438002845	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
370438002846	Metal-binding active site; metal-binding site
370438002847	pyruvoyl-dependent arginine decarboxylase; Reviewed; Region: PRK01285
370438002848	spermidine synthase; Provisional; Region: PRK00811
370438002849	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
370438002850	agmatinase; Region: agmatinase; TIGR01230
370438002851	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
370438002852	putative active site [active]
370438002853	Mn binding site [ion binding]; other site
370438002854	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
370438002855	phosphate binding site [ion binding]; other site
370438002856	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
370438002857	Uncharacterized conserved protein [Function unknown]; Region: COG1284
370438002858	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
370438002859	ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397
370438002860	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
370438002861	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
370438002862	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13639
370438002863	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
370438002864	Walker A/P-loop; other site
370438002865	ATP binding site [chemical binding]; other site
370438002866	Q-loop/lid; other site
370438002867	ABC transporter signature motif; other site
370438002868	Walker B; other site
370438002869	D-loop; other site
370438002870	H-loop/switch region; other site
370438002871	cobalt-precorrin-6A synthase; Reviewed; Region: cbiD; PRK00075
370438002872	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
370438002873	active site
370438002874	putative homodimer interface [polypeptide binding]; other site
370438002875	SAM binding site [chemical binding]; other site
370438002876	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
370438002877	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
370438002878	S-adenosylmethionine binding site [chemical binding]; other site
370438002879	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
370438002880	active site
370438002881	SAM binding site [chemical binding]; other site
370438002882	homodimer interface [polypeptide binding]; other site
370438002883	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
370438002884	active site
370438002885	SAM binding site [chemical binding]; other site
370438002886	homodimer interface [polypeptide binding]; other site
370438002887	cobalamin biosynthesis protein CbiG; Validated; Region: PRK05788
370438002888	Cobalamin synthesis G N-terminal; Region: CbiG_N; pfam11760
370438002889	Cobalamin biosynthesis central region; Region: CbiG_mid; pfam11761
370438002890	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
370438002891	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
370438002892	homodimer interface [polypeptide binding]; other site
370438002893	active site
370438002894	SAM binding site [chemical binding]; other site
370438002895	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
370438002896	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
370438002897	putative active site [active]
370438002898	Precorrin-8X methylmutase; Region: CbiC; pfam02570
370438002899	cobalt-precorrin-8X methylmutase; Validated; Region: cbiC; cl00913
370438002900	cobyric acid synthase; Provisional; Region: PRK00784
370438002901	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
370438002902	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
370438002903	catalytic triad [active]
370438002904	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
370438002905	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
370438002906	catalytic triad [active]
370438002907	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
370438002908	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
370438002909	membrane-bound complex binding site; other site
370438002910	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
370438002911	Uncharacterized conserved protein [Function unknown]; Region: COG1751
370438002912	Pyruvate kinase, alpha/beta domain; Region: PK_C; pfam02887
370438002913	Thioredoxin reductase [Posttranslational modification, protein turnover, chaperones]; Region: TrxB; COG0492
370438002914	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
370438002915	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK12437
370438002916	Glycerophosphodiester phosphodiesterase domain of Streptomyces coelicolor cytoplasmic phosphodiesterases UgpQ2 and similar proteins; Region: GDPD_cytoplasmic_ScUgpQ2_like; cd08561
370438002917	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
370438002918	putative active site [active]
370438002919	catalytic site [active]
370438002920	putative metal binding site [ion binding]; other site
370438002921	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
370438002922	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
370438002923	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
370438002924	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
370438002925	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
370438002926	substrate binding pocket [chemical binding]; other site
370438002927	chain length determination region; other site
370438002928	substrate-Mg2+ binding site; other site
370438002929	catalytic residues [active]
370438002930	aspartate-rich region 1; other site
370438002931	active site lid residues [active]
370438002932	aspartate-rich region 2; other site
370438002933	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
370438002934	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
370438002935	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
370438002936	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
370438002937	tRNA; other site
370438002938	putative tRNA binding site [nucleotide binding]; other site
370438002939	putative NADP binding site [chemical binding]; other site
370438002940	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
370438002941	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
370438002942	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494
370438002943	domain interfaces; other site
370438002944	active site
370438002945	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
370438002946	active site
370438002947	SAM binding site [chemical binding]; other site
370438002948	homodimer interface [polypeptide binding]; other site
370438002949	Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587
370438002950	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
370438002951	active site
370438002952	putative heme d1 biosynthesis radical SAM protein NirJ1; Region: rSAM_NirJ1; TIGR04054
370438002953	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370438002954	FeS/SAM binding site; other site
370438002955	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
370438002956	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384
370438002957	dimer interface [polypeptide binding]; other site
370438002958	active site
370438002959	Schiff base residues; other site
370438002960	putative heme d1 biosynthesis radical SAM protein NirJ2; Region: rSAM_NirJ2; TIGR04055
370438002961	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370438002962	FeS/SAM binding site; other site
370438002963	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
370438002964	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
370438002965	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
370438002966	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
370438002967	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
370438002968	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
370438002969	inhibitor-cofactor binding pocket; inhibition site
370438002970	pyridoxal 5'-phosphate binding site [chemical binding]; other site
370438002971	catalytic residue [active]
370438002972	putative iron-only hydrogenase system regulator; Region: hyd_TM1266; TIGR03959
370438002973	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
370438002974	Aspartase; Region: Aspartase; cd01357
370438002975	active sites [active]
370438002976	tetramer interface [polypeptide binding]; other site
370438002977	[FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918
370438002978	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
370438002979	G1 box; other site
370438002980	GTP/Mg2+ binding site [chemical binding]; other site
370438002981	Switch I region; other site
370438002982	G2 box; other site
370438002983	Switch II region; other site
370438002984	G3 box; other site
370438002985	G4 box; other site
370438002986	G5 box; other site
370438002987	biotin synthase; Provisional; Region: PRK07094
370438002988	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370438002989	FeS/SAM binding site; other site
370438002990	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613
370438002991	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370438002992	FeS/SAM binding site; other site
370438002993	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
370438002994	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
370438002995	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
370438002996	CoA binding domain; Region: CoA_binding; smart00881
370438002997	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
370438002998	Uncharacterized proteins with similarity to Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL_like_DUF711; cd08025
370438002999	ACT domain proteins similar to the yet uncharacterized Streptococcus pneumoniae ACT domain protein; Region: ACT_1ZPV; cd04872
370438003000	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
370438003001	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
370438003002	active site
370438003003	nucleophile elbow; other site
370438003004	Domain of Unknown Function (DUF1540); Region: DUF1540; pfam07561
370438003005	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
370438003006	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
370438003007	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370438003008	FeS/SAM binding site; other site
370438003009	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
370438003010	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
370438003011	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
370438003012	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
370438003013	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
370438003014	Zn2+ binding site [ion binding]; other site
370438003015	Mg2+ binding site [ion binding]; other site
370438003016	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
370438003017	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
370438003018	Zn2+ binding site [ion binding]; other site
370438003019	Mg2+ binding site [ion binding]; other site
370438003020	The accessory protein CooC, which contains a nucleotide-binding domain (P-loop) near the N-terminus, participates in the maturation of the nickel center of carbon monoxide dehydrogenase (CODH). CODH from Rhodospirillum rubrum catalyzes the reversible...; Region: CooC; cd02034
370438003021	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
370438003022	acetyl-CoA decarbonylase/synthase complex subunit gamma; Provisional; Region: PRK04165
370438003023	Putative Fe-S cluster; Region: FeS; cl17515
370438003024	Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894
370438003025	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
370438003026	catalytic loop [active]
370438003027	iron binding site [ion binding]; other site
370438003028	acetyl-CoA decarbonylase/synthase complex subunit delta; Provisional; Region: PRK04452
370438003029	methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535
370438003030	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
370438003031	substrate binding pocket [chemical binding]; other site
370438003032	dimer interface [polypeptide binding]; other site
370438003033	inhibitor binding site; inhibition site
370438003034	Methylene-tetrahydrofolate reductase C terminal; Region: MTHFR_C; pfam12225
370438003035	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
370438003036	FAD binding site [chemical binding]; other site
370438003037	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
370438003038	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
370438003039	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
370438003040	phosphoenolpyruvate carboxykinase; Provisional; Region: PRK09344
370438003041	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
370438003042	active site
370438003043	metal-binding site [ion binding]
370438003044	nucleotide-binding site [chemical binding]; other site
370438003045	Putative primosome component and related proteins [DNA replication, recombination, and repair]; Region: DnaD; COG3935
370438003046	Replication initiation and membrane attachment; Region: DnaB_2; pfam07261
370438003047	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438003048	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
370438003049	Walker A motif; other site
370438003050	ATP binding site [chemical binding]; other site
370438003051	Walker B motif; other site
370438003052	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
370438003053	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
370438003054	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
370438003055	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
370438003056	Asp23 family; Region: Asp23; pfam03780
370438003057	Transglycosylase; Region: Transgly; pfam00912
370438003058	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
370438003059	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
370438003060	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
370438003061	putative active site pocket [active]
370438003062	dimerization interface [polypeptide binding]; other site
370438003063	putative catalytic residue [active]
370438003064	Succinate:quinone oxidoreductase (SQR) and Quinol:fumarate reductase (QFR) family, transmembrane subunits; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol, while QFR catalyzes the reverse reaction. SQR; Region: SQR_QFR_TM; cl00881
370438003065	Iron-sulfur protein interface; other site
370438003066	proximal heme binding site [chemical binding]; other site
370438003067	fumarate reductase flavoprotein subunit; Provisional; Region: PRK08626
370438003068	L-aspartate oxidase; Provisional; Region: PRK06175
370438003069	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
370438003070	fumarate reductase iron-sulfur subunit; Provisional; Region: frdB; PRK13552
370438003071	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
370438003072	Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA; cl01007
370438003073	SxDxEG motif; other site
370438003074	active site
370438003075	metal binding site [ion binding]; metal-binding site
370438003076	homopentamer interface [polypeptide binding]; other site
370438003077	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
370438003078	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
370438003079	active site
370438003080	HIGH motif; other site
370438003081	dimer interface [polypeptide binding]; other site
370438003082	KMSKS motif; other site
370438003083	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
370438003084	RNA binding surface [nucleotide binding]; other site
370438003085	Sporulation protein YunB (Spo_YunB); Region: Spore_YunB; cl09783
370438003086	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
370438003087	CoenzymeA binding site [chemical binding]; other site
370438003088	subunit interaction site [polypeptide binding]; other site
370438003089	PHB binding site; other site
370438003090	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
370438003091	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
370438003092	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
370438003093	hypothetical protein; Validated; Region: PRK00110
370438003094	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
370438003095	active site
370438003096	putative DNA-binding cleft [nucleotide binding]; other site
370438003097	dimer interface [polypeptide binding]; other site
370438003098	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
370438003099	RuvA N terminal domain; Region: RuvA_N; pfam01330
370438003100	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
370438003101	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
370438003102	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438003103	Walker A motif; other site
370438003104	ATP binding site [chemical binding]; other site
370438003105	Walker B motif; other site
370438003106	arginine finger; other site
370438003107	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
370438003108	Uncharacterized BCR, COG1636; Region: DUF208; cl17782
370438003109	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
370438003110	Stage II sporulation protein; Region: SpoIID; pfam08486
370438003111	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
370438003112	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
370438003113	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
370438003114	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
370438003115	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
370438003116	Preprotein translocase subunit; Region: YajC; pfam02699
370438003117	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
370438003118	Zn2+ binding site [ion binding]; other site
370438003119	Mg2+ binding site [ion binding]; other site
370438003120	protein-export membrane protein SecD; Region: secD; TIGR01129
370438003121	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
370438003122	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
370438003123	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
370438003124	Protein export membrane protein; Region: SecD_SecF; pfam02355
370438003125	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
370438003126	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
370438003127	Ligand Binding Site [chemical binding]; other site
370438003128	Bifunctional nuclease; Region: DNase-RNase; pfam02577
370438003129	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
370438003130	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
370438003131	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
370438003132	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
370438003133	DHH family; Region: DHH; pfam01368
370438003134	DHHA1 domain; Region: DHHA1; pfam02272
370438003135	helicase superfamily c-terminal domain; Region: HELICc; smart00490
370438003136	nucleotide binding region [chemical binding]; other site
370438003137	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
370438003138	active site
370438003139	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
370438003140	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
370438003141	Zn2+ binding site [ion binding]; other site
370438003142	Mg2+ binding site [ion binding]; other site
370438003143	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
370438003144	synthetase active site [active]
370438003145	NTP binding site [chemical binding]; other site
370438003146	metal binding site [ion binding]; metal-binding site
370438003147	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
370438003148	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
370438003149	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
370438003150	putative active site [active]
370438003151	dimerization interface [polypeptide binding]; other site
370438003152	putative tRNAtyr binding site [nucleotide binding]; other site
370438003153	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
370438003154	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
370438003155	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
370438003156	dimer interface [polypeptide binding]; other site
370438003157	motif 1; other site
370438003158	active site
370438003159	motif 2; other site
370438003160	motif 3; other site
370438003161	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
370438003162	anticodon binding site; other site
370438003163	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
370438003164	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
370438003165	dimer interface [polypeptide binding]; other site
370438003166	anticodon binding site; other site
370438003167	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
370438003168	homodimer interface [polypeptide binding]; other site
370438003169	motif 1; other site
370438003170	active site
370438003171	motif 2; other site
370438003172	GAD domain; Region: GAD; pfam02938
370438003173	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
370438003174	motif 3; other site
370438003175	Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 1 [Coenzyme metabolism]; Region: COG1179
370438003176	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
370438003177	putative ATP binding site [chemical binding]; other site
370438003178	putative substrate interface [chemical binding]; other site
370438003179	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
370438003180	catalytic residues [active]
370438003181	recombination factor protein RarA; Reviewed; Region: PRK13342
370438003182	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438003183	Walker A motif; other site
370438003184	ATP binding site [chemical binding]; other site
370438003185	Walker B motif; other site
370438003186	arginine finger; other site
370438003187	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
370438003188	Transcriptional regulator; Region: Rrf2; cl17282
370438003189	Predicted transcriptional regulator [Transcription]; Region: COG1959
370438003190	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
370438003191	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
370438003192	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
370438003193	catalytic residue [active]
370438003194	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
370438003195	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
370438003196	trimerization site [polypeptide binding]; other site
370438003197	active site
370438003198	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
370438003199	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
370438003200	Ligand Binding Site [chemical binding]; other site
370438003201	Domain of unknown function DUF20; Region: UPF0118; pfam01594
370438003202	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
370438003203	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
370438003204	tRNA synthetases class II (A); Region: tRNA-synt_2c; pfam01411
370438003205	motif 1; other site
370438003206	active site
370438003207	motif 2; other site
370438003208	motif 3; other site
370438003209	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
370438003210	DHHA1 domain; Region: DHHA1; pfam02272
370438003211	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
370438003212	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
370438003213	Coenzyme A binding pocket [chemical binding]; other site
370438003214	hypothetical protein; Provisional; Region: PRK05473
370438003215	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
370438003216	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
370438003217	active site
370438003218	catalytic tetrad [active]
370438003219	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
370438003220	Protein of unknown function (DUF1292); Region: DUF1292; pfam06949
370438003221	Putative peptidoglycan binding domain; Region: PG_binding_4; pfam12229
370438003222	VanW like protein; Region: VanW; pfam04294
370438003223	G5 domain; Region: G5; pfam07501
370438003224	YceG-like family; Region: YceG; pfam02618
370438003225	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
370438003226	dimerization interface [polypeptide binding]; other site
370438003227	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
370438003228	Peptidase family U32; Region: Peptidase_U32; pfam01136
370438003229	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
370438003230	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
370438003231	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
370438003232	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
370438003233	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
370438003234	non-specific DNA binding site [nucleotide binding]; other site
370438003235	salt bridge; other site
370438003236	sequence-specific DNA binding site [nucleotide binding]; other site
370438003237	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
370438003238	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
370438003239	non-specific DNA binding site [nucleotide binding]; other site
370438003240	salt bridge; other site
370438003241	sequence-specific DNA binding site [nucleotide binding]; other site
370438003242	transcriptional repressor DicA; Reviewed; Region: PRK09706
370438003243	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
370438003244	non-specific DNA binding site [nucleotide binding]; other site
370438003245	salt bridge; other site
370438003246	sequence-specific DNA binding site [nucleotide binding]; other site
370438003247	Predicted membrane protein [Function unknown]; Region: COG3462
370438003248	Short C-terminal domain; Region: SHOCT; pfam09851
370438003249	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
370438003250	Methyltransferase domain; Region: Methyltransf_23; pfam13489
370438003251	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
370438003252	S-adenosylmethionine binding site [chemical binding]; other site
370438003253	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
370438003254	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
370438003255	Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719
370438003256	NAD(P) binding site [chemical binding]; other site
370438003257	homodimer interface [polypeptide binding]; other site
370438003258	substrate binding site [chemical binding]; other site
370438003259	active site
370438003260	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
370438003261	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
370438003262	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
370438003263	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
370438003264	G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189
370438003265	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
370438003266	substrate binding site; other site
370438003267	metal-binding site
370438003268	Oligomer interface; other site
370438003269	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
370438003270	dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898
370438003271	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
370438003272	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
370438003273	NADP binding site [chemical binding]; other site
370438003274	active site
370438003275	putative substrate binding site [chemical binding]; other site
370438003276	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
370438003277	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
370438003278	NAD binding site [chemical binding]; other site
370438003279	substrate binding site [chemical binding]; other site
370438003280	homodimer interface [polypeptide binding]; other site
370438003281	active site
370438003282	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
370438003283	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
370438003284	Protein of unknown function (DUF2837); Region: DUF2837; pfam10997
370438003285	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
370438003286	L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556
370438003287	Probable Catalytic site; other site
370438003288	metal-binding site
370438003289	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
370438003290	S-adenosylmethionine binding site [chemical binding]; other site
370438003291	Protein of unknown function (DUF2837); Region: DUF2837; pfam10997
370438003292	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053
370438003293	active site
370438003294	catalytic triad [active]
370438003295	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
370438003296	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
370438003297	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
370438003298	active site residue [active]
370438003299	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
370438003300	active site residue [active]
370438003301	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
370438003302	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
370438003303	active site residue [active]
370438003304	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
370438003305	active site residue [active]
370438003306	Bacterial SH3 domain; Region: SH3_3; pfam08239
370438003307	Capsular polysaccharide biosynthesis protein [Cell envelope biogenesis, outer membrane]; Region: COG3944
370438003308	Chain length determinant protein; Region: Wzz; cl15801
370438003309	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
370438003310	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
370438003311	UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256
370438003312	Vi polysaccharide biosynthesis protein TviC; Provisional; Region: PRK15181
370438003313	NAD binding site [chemical binding]; other site
370438003314	substrate binding site [chemical binding]; other site
370438003315	homodimer interface [polypeptide binding]; other site
370438003316	active site
370438003317	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
370438003318	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
370438003319	putative ADP-binding pocket [chemical binding]; other site
370438003320	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
370438003321	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088
370438003322	putative ADP-binding pocket [chemical binding]; other site
370438003323	Uncharacterized conserved protein [Function unknown]; Region: COG1434
370438003324	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
370438003325	putative active site [active]
370438003326	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
370438003327	Bacterial sugar transferase; Region: Bac_transf; pfam02397
370438003328	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
370438003329	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370438003330	NAD(P) binding site [chemical binding]; other site
370438003331	active site
370438003332	Right handed beta helix region; Region: Beta_helix; pfam13229
370438003333	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
370438003334	Interdomain contacts; other site
370438003335	Cytokine receptor motif; other site
370438003336	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
370438003337	active site
370438003338	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
370438003339	homodimer interface [polypeptide binding]; other site
370438003340	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
370438003341	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
370438003342	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
370438003343	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
370438003344	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
370438003345	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
370438003346	putative ADP-binding pocket [chemical binding]; other site
370438003347	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
370438003348	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
370438003349	MviN-like protein; Region: MVIN; pfam03023
370438003350	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
370438003351	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
370438003352	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
370438003353	putative trimer interface [polypeptide binding]; other site
370438003354	putative CoA binding site [chemical binding]; other site
370438003355	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
370438003356	putative trimer interface [polypeptide binding]; other site
370438003357	putative active site [active]
370438003358	putative substrate binding site [chemical binding]; other site
370438003359	putative CoA binding site [chemical binding]; other site
370438003360	Chain length determinant protein; Region: Wzz; pfam02706
370438003361	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
370438003362	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
370438003363	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
370438003364	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
370438003365	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
370438003366	inhibitor-cofactor binding pocket; inhibition site
370438003367	pyridoxal 5'-phosphate binding site [chemical binding]; other site
370438003368	catalytic residue [active]
370438003369	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
370438003370	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
370438003371	inhibitor-cofactor binding pocket; inhibition site
370438003372	pyridoxal 5'-phosphate binding site [chemical binding]; other site
370438003373	catalytic residue [active]
370438003374	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14959
370438003375	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
370438003376	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
370438003377	putative metal binding site; other site
370438003378	type IV pilus biogenesis/stability protein PilW; Region: type_IV_pilW; TIGR02521
370438003379	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
370438003380	TPR motif; other site
370438003381	binding surface
370438003382	Tetratricopeptide repeat; Region: TPR_16; pfam13432
370438003383	Tetratricopeptide repeat; Region: TPR_16; pfam13432
370438003384	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
370438003385	TPR motif; other site
370438003386	binding surface
370438003387	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
370438003388	putative metal binding site; other site
370438003389	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
370438003390	binding surface
370438003391	TPR motif; other site
370438003392	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
370438003393	binding surface
370438003394	TPR repeat; Region: TPR_11; pfam13414
370438003395	TPR motif; other site
370438003396	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
370438003397	putative metal binding site; other site
370438003398	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
370438003399	TPR motif; other site
370438003400	binding surface
370438003401	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
370438003402	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
370438003403	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
370438003404	active site
370438003405	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
370438003406	DNA binding residues [nucleotide binding]
370438003407	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
370438003408	DNA methylase; Region: N6_N4_Mtase; pfam01555
370438003409	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
370438003410	S-adenosylmethionine binding site [chemical binding]; other site
370438003411	MjaII restriction endonuclease; Region: RE_MjaII; pfam09520
370438003412	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
370438003413	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
370438003414	catalytic residues [active]
370438003415	catalytic nucleophile [active]
370438003416	Recombinase; Region: Recombinase; pfam07508
370438003417	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
370438003418	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
370438003419	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
370438003420	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
370438003421	GTP binding site; other site
370438003422	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
370438003423	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
370438003424	active site
370438003425	motif I; other site
370438003426	motif II; other site
370438003427	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
370438003428	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
370438003429	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
370438003430	NAD(P) binding site [chemical binding]; other site
370438003431	shikimate binding site; other site
370438003432	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
370438003433	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
370438003434	Tetramer interface [polypeptide binding]; other site
370438003435	active site
370438003436	FMN-binding site [chemical binding]; other site
370438003437	shikimate kinase; Provisional; Region: PRK13947
370438003438	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
370438003439	ADP binding site [chemical binding]; other site
370438003440	magnesium binding site [ion binding]; other site
370438003441	putative shikimate binding site; other site
370438003442	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
370438003443	active site
370438003444	dimer interface [polypeptide binding]; other site
370438003445	metal binding site [ion binding]; metal-binding site
370438003446	DDE superfamily endonuclease; Region: DDE_5; cl17874
370438003447	Type II/IV secretion system protein; Region: T2SE; pfam00437
370438003448	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
370438003449	Walker A motif; other site
370438003450	ATP binding site [chemical binding]; other site
370438003451	Walker B motif; other site
370438003452	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
370438003453	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
370438003454	Walker A motif; other site
370438003455	ATP binding site [chemical binding]; other site
370438003456	Walker B motif; other site
370438003457	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
370438003458	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
370438003459	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
370438003460	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
370438003461	Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830
370438003462	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
370438003463	Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972
370438003464	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
370438003465	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
370438003466	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
370438003467	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
370438003468	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
370438003469	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
370438003470	Walker A motif; other site
370438003471	ATP binding site [chemical binding]; other site
370438003472	Walker B motif; other site
370438003473	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
370438003474	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
370438003475	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
370438003476	Walker A motif; other site
370438003477	Walker A/P-loop; other site
370438003478	ATP binding site [chemical binding]; other site
370438003479	ATP binding site [chemical binding]; other site
370438003480	Walker B motif; other site
370438003481	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
370438003482	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
370438003483	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
370438003484	DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191
370438003485	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
370438003486	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
370438003487	DNA binding residues [nucleotide binding]
370438003488	Competence protein A; Region: Competence_A; pfam11104
370438003489	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
370438003490	Pilus assembly protein, PilO; Region: PilO; cl01234
370438003491	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
370438003492	PilX N-terminal; Region: PilX_N; pfam14341
370438003493	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
370438003494	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
370438003495	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
370438003496	Dehydroquinase class II; Region: DHquinase_II; pfam01220
370438003497	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
370438003498	trimer interface [polypeptide binding]; other site
370438003499	active site
370438003500	dimer interface [polypeptide binding]; other site
370438003501	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
370438003502	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
370438003503	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
370438003504	active site
370438003505	elongation factor P; Validated; Region: PRK00529
370438003506	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
370438003507	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
370438003508	RNA binding site [nucleotide binding]; other site
370438003509	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
370438003510	RNA binding site [nucleotide binding]; other site
370438003511	coenzyme A disulfide reductase; Reviewed; Region: PRK09564
370438003512	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
370438003513	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
370438003514	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
370438003515	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
370438003516	active site residue [active]
370438003517	stage III sporulation protein AA; Region: spore_III_AA; TIGR02858
370438003518	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
370438003519	Walker A motif; other site
370438003520	ATP binding site [chemical binding]; other site
370438003521	stage III sporulation protein SpoAB; Provisional; Region: PRK08307
370438003522	stage III sporulation protein AC; Region: spore_III_AC; TIGR02848
370438003523	stage III sporulation protein AD; Region: spore_III_AD; TIGR02849
370438003524	Stage III sporulation protein AE (spore_III_AE); Region: Spore_III_AE; pfam09546
370438003525	Stage III sporulation protein AF (Spore_III_AF); Region: Spore_III_AF; pfam09581
370438003526	stage III sporulation protein AG; Region: spore_III_AG; TIGR02830
370438003527	SpoIIIAH-like protein; Region: SpoIIIAH; pfam12685
370438003528	pyruvate carboxylase subunit B; Validated; Region: PRK09282
370438003529	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
370438003530	active site
370438003531	catalytic residues [active]
370438003532	metal binding site [ion binding]; metal-binding site
370438003533	homodimer binding site [polypeptide binding]; other site
370438003534	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
370438003535	carboxyltransferase (CT) interaction site; other site
370438003536	biotinylation site [posttranslational modification]; other site
370438003537	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
370438003538	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
370438003539	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
370438003540	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
370438003541	Asp23 family; Region: Asp23; pfam03780
370438003542	Asp23 family; Region: Asp23; pfam03780
370438003543	Small integral membrane protein (DUF2273); Region: DUF2273; cl11575
370438003544	Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619
370438003545	putative RNA binding site [nucleotide binding]; other site
370438003546	ferredoxin-NADP(+) reductase subunit alpha; Reviewed; Region: PRK06222
370438003547	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
370438003548	FAD binding pocket [chemical binding]; other site
370438003549	FAD binding motif [chemical binding]; other site
370438003550	phosphate binding motif [ion binding]; other site
370438003551	beta-alpha-beta structure motif; other site
370438003552	NAD binding pocket [chemical binding]; other site
370438003553	Iron coordination center [ion binding]; other site
370438003554	putative oxidoreductase; Provisional; Region: PRK12831
370438003555	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
370438003556	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; smart01002
370438003557	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
370438003558	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
370438003559	generic binding surface II; other site
370438003560	generic binding surface I; other site
370438003561	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
370438003562	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
370438003563	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
370438003564	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
370438003565	homodimer interface [polypeptide binding]; other site
370438003566	NADP binding site [chemical binding]; other site
370438003567	substrate binding site [chemical binding]; other site
370438003568	Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
370438003569	4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160
370438003570	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
370438003571	inhibitor-cofactor binding pocket; inhibition site
370438003572	pyridoxal 5'-phosphate binding site [chemical binding]; other site
370438003573	catalytic residue [active]
370438003574	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
370438003575	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
370438003576	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
370438003577	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
370438003578	putative active site [active]
370438003579	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
370438003580	carboxyltransferase (CT) interaction site; other site
370438003581	biotinylation site [posttranslational modification]; other site
370438003582	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
370438003583	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
370438003584	ATP-grasp domain; Region: ATP-grasp_4; cl17255
370438003585	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
370438003586	PAS domain; Region: PAS_9; pfam13426
370438003587	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
370438003588	putative active site [active]
370438003589	heme pocket [chemical binding]; other site
370438003590	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438003591	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
370438003592	Walker A motif; other site
370438003593	ATP binding site [chemical binding]; other site
370438003594	Walker B motif; other site
370438003595	arginine finger; other site
370438003596	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
370438003597	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
370438003598	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
370438003599	substrate binding pocket [chemical binding]; other site
370438003600	chain length determination region; other site
370438003601	substrate-Mg2+ binding site; other site
370438003602	catalytic residues [active]
370438003603	aspartate-rich region 1; other site
370438003604	active site lid residues [active]
370438003605	aspartate-rich region 2; other site
370438003606	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
370438003607	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
370438003608	TPP-binding site; other site
370438003609	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
370438003610	PYR/PP interface [polypeptide binding]; other site
370438003611	dimer interface [polypeptide binding]; other site
370438003612	TPP binding site [chemical binding]; other site
370438003613	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
370438003614	Predicted rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: COG1189
370438003615	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
370438003616	RNA binding surface [nucleotide binding]; other site
370438003617	FtsJ-like methyltransferase; Region: FtsJ; pfam01728
370438003618	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
370438003619	ATP-NAD kinase; Region: NAD_kinase; pfam01513
370438003620	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
370438003621	S-adenosylmethionine binding site [chemical binding]; other site
370438003622	arginine repressor; Provisional; Region: PRK04280
370438003623	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
370438003624	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
370438003625	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
370438003626	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
370438003627	Walker A/P-loop; other site
370438003628	ATP binding site [chemical binding]; other site
370438003629	Q-loop/lid; other site
370438003630	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
370438003631	ABC transporter signature motif; other site
370438003632	Walker B; other site
370438003633	D-loop; other site
370438003634	H-loop/switch region; other site
370438003635	stage IV sporulation protein B; Region: spore_IV_B; TIGR02860
370438003636	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
370438003637	SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580
370438003638	sporulation transcription factor Spo0A; Region: spore_0_A; TIGR02875
370438003639	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370438003640	active site
370438003641	phosphorylation site [posttranslational modification]
370438003642	intermolecular recognition site; other site
370438003643	dimerization interface [polypeptide binding]; other site
370438003644	Sporulation initiation factor Spo0A C terminal; Region: Spo0A_C; pfam08769
370438003645	Ferredoxin [Energy production and conversion]; Region: COG1146
370438003646	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
370438003647	2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119
370438003648	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
370438003649	dimer interface [polypeptide binding]; other site
370438003650	PYR/PP interface [polypeptide binding]; other site
370438003651	TPP binding site [chemical binding]; other site
370438003652	substrate binding site [chemical binding]; other site
370438003653	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
370438003654	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013
370438003655	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
370438003656	TPP-binding site [chemical binding]; other site
370438003657	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
370438003658	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558
370438003659	M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683
370438003660	peptidase T-like protein; Region: PepT-like; TIGR01883
370438003661	metal binding site [ion binding]; metal-binding site
370438003662	putative dimer interface [polypeptide binding]; other site
370438003663	Integral membrane protein DUF95; Region: DUF95; cl00572
370438003664	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
370438003665	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
370438003666	active site
370438003667	Int/Topo IB signature motif; other site
370438003668	phosphopentomutase; Provisional; Region: PRK05362
370438003669	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
370438003670	pyrimidine-nucleoside phosphorylase; Region: Y_phosphoryl; TIGR02644
370438003671	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
370438003672	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
370438003673	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
370438003674	Transposase domain (DUF772); Region: DUF772; pfam05598
370438003675	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
370438003676	Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696
370438003677	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
370438003678	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
370438003679	putative NTP binding site [chemical binding]; other site
370438003680	Homeodomain-like domain; Region: HTH_32; pfam13565
370438003681	Integrase core domain; Region: rve; pfam00665
370438003682	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
370438003683	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
370438003684	Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368
370438003685	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
370438003686	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
370438003687	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
370438003688	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
370438003689	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
370438003690	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
370438003691	anti sigma factor interaction site; other site
370438003692	regulatory phosphorylation site [posttranslational modification]; other site
370438003693	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
370438003694	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
370438003695	ATP binding site [chemical binding]; other site
370438003696	Mg2+ binding site [ion binding]; other site
370438003697	G-X-G motif; other site
370438003698	sporulation sigma factor SigF; Validated; Region: PRK05572
370438003699	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
370438003700	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
370438003701	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
370438003702	DNA binding residues [nucleotide binding]
370438003703	Dodecin; Region: Dodecin; pfam07311
370438003704	SpoVA protein; Region: SpoVA; cl04298
370438003705	stage V sporulation protein AD; Validated; Region: PRK08304
370438003706	stage V sporulation protein AD; Provisional; Region: PRK12404
370438003707	stage V sporulation protein AE; Region: spore_V_AE; TIGR02839
370438003708	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
370438003709	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989
370438003710	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
370438003711	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
370438003712	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
370438003713	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
370438003714	diaminopimelate decarboxylase; Region: lysA; TIGR01048
370438003715	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
370438003716	active site
370438003717	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
370438003718	substrate binding site [chemical binding]; other site
370438003719	catalytic residues [active]
370438003720	dimer interface [polypeptide binding]; other site
370438003721	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
370438003722	DHH family; Region: DHH; pfam01368
370438003723	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
370438003724	FOG: CBS domain [General function prediction only]; Region: COG0517
370438003725	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595
370438003726	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
370438003727	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
370438003728	active site
370438003729	NTP binding site [chemical binding]; other site
370438003730	metal binding triad [ion binding]; metal-binding site
370438003731	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
370438003732	tRNA nucleotidyltransferase domain 2 putative; Region: tRNA_NucTran2_2; pfam13735
370438003733	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_1; cd06158
370438003734	Peptidase family M50; Region: Peptidase_M50; pfam02163
370438003735	active site
370438003736	putative substrate binding region [chemical binding]; other site
370438003737	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
370438003738	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
370438003739	active site
370438003740	HIGH motif; other site
370438003741	dimer interface [polypeptide binding]; other site
370438003742	KMSKS motif; other site
370438003743	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
370438003744	Protein of unknown function (DUF2953); Region: DUF2953; pfam11167
370438003745	Sporulation protein YtfJ (Spore_YtfJ); Region: Spore_YtfJ; cl01596
370438003746	Ku protein, prokaryotic; Region: Ku_bact; TIGR02772
370438003747	Ku-core domain, Ku-like subfamily; composed of prokaryotic homologs of the eukaryotic DNA binding protein Ku. The alignment includes the core domain shared by the prokaryotic YkoV-like proteins and the eukaryotic Ku70 and Ku80. The prokaryotic Ku...; Region: KU_like; cd00789
370438003748	putative DNA binding site [nucleotide binding]; other site
370438003749	putative homodimer interface [polypeptide binding]; other site
370438003750	Adenylation domain of Mycobacterium tuberculosis LigD and LigC-like ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_LigD_LigC; cd07906
370438003751	DNA polymerase LigD, ligase domain; Region: NHEJ_ligase_lig; TIGR02779
370438003752	active site
370438003753	DNA binding site [nucleotide binding]
370438003754	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of ATP-dependent DNA ligase LigD is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_LigD; cd07971
370438003755	DNA binding site [nucleotide binding]
370438003756	LigD_Pol_like_2: Polymerase (Pol) domain of bacterial LigD proteins similar to Pseudomonas aeruginosa (Pae) LigD, subgroup 2. The LigD Pol domain belongs to the archaeal/eukaryal primase (AEP) superfamily. In prokaryotes, LigD along with Ku is required...; Region: LigD_Pol_like_2; cd04865
370438003757	nucleotide binding site [chemical binding]; other site
370438003758	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
370438003759	DNA protecting protein DprA; Region: dprA; TIGR00732
370438003760	DNA topoisomerase I; Validated; Region: PRK05582
370438003761	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
370438003762	active site
370438003763	interdomain interaction site; other site
370438003764	putative metal-binding site [ion binding]; other site
370438003765	nucleotide binding site [chemical binding]; other site
370438003766	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
370438003767	domain I; other site
370438003768	DNA binding groove [nucleotide binding]
370438003769	phosphate binding site [ion binding]; other site
370438003770	domain II; other site
370438003771	domain III; other site
370438003772	nucleotide binding site [chemical binding]; other site
370438003773	catalytic site [active]
370438003774	domain IV; other site
370438003775	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
370438003776	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
370438003777	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
370438003778	Glucose inhibited division protein A; Region: GIDA; pfam01134
370438003779	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
370438003780	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
370438003781	active site
370438003782	DNA binding site [nucleotide binding]
370438003783	Int/Topo IB signature motif; other site
370438003784	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
370438003785	active site
370438003786	HslU subunit interaction site [polypeptide binding]; other site
370438003787	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
370438003788	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438003789	Walker A motif; other site
370438003790	ATP binding site [chemical binding]; other site
370438003791	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
370438003792	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
370438003793	transcriptional repressor CodY; Validated; Region: PRK04158
370438003794	CodY GAF-like domain; Region: CodY; pfam06018
370438003795	CodY helix-turn-helix domain; Region: HTH_CodY; pfam08222
370438003796	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
370438003797	rRNA interaction site [nucleotide binding]; other site
370438003798	S8 interaction site; other site
370438003799	putative laminin-1 binding site; other site
370438003800	elongation factor Ts; Reviewed; Region: tsf; PRK12332
370438003801	UBA/TS-N domain; Region: UBA; pfam00627
370438003802	Elongation factor TS; Region: EF_TS; pfam00889
370438003803	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
370438003804	putative nucleotide binding site [chemical binding]; other site
370438003805	uridine monophosphate binding site [chemical binding]; other site
370438003806	homohexameric interface [polypeptide binding]; other site
370438003807	ribosome recycling factor; Reviewed; Region: frr; PRK00083
370438003808	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
370438003809	hinge region; other site
370438003810	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
370438003811	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
370438003812	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
370438003813	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
370438003814	catalytic residue [active]
370438003815	putative FPP diphosphate  binding site; other site
370438003816	putative FPP binding hydrophobic cleft; other site
370438003817	dimer interface [polypeptide binding]; other site
370438003818	putative IPP diphosphate binding site; other site
370438003819	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
370438003820	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
370438003821	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
370438003822	Domain of unknown function DUF20; Region: UPF0118; pfam01594
370438003823	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
370438003824	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
370438003825	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
370438003826	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
370438003827	Predicted membrane-associated Zn-dependent proteases 1 [Cell envelope biogenesis, outer membrane]; Region: COG0750
370438003828	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
370438003829	active site
370438003830	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
370438003831	protein binding site [polypeptide binding]; other site
370438003832	Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020
370438003833	putative substrate binding region [chemical binding]; other site
370438003834	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
370438003835	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
370438003836	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
370438003837	prolyl-tRNA synthetase; Provisional; Region: PRK09194
370438003838	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
370438003839	dimer interface [polypeptide binding]; other site
370438003840	motif 1; other site
370438003841	active site
370438003842	motif 2; other site
370438003843	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
370438003844	putative deacylase active site [active]
370438003845	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
370438003846	active site
370438003847	motif 3; other site
370438003848	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
370438003849	anticodon binding site; other site
370438003850	Monogalactosyldiacylglycerol (MGDG) synthase; Region: MGDG_synth; pfam06925
370438003851	monogalactosyldiacylglycerol synthase; Region: PLN02605
370438003852	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
370438003853	Sm and related proteins; Region: Sm_like; cl00259
370438003854	ribosome maturation protein RimP; Reviewed; Region: PRK00092
370438003855	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
370438003856	putative oligomer interface [polypeptide binding]; other site
370438003857	putative RNA binding site [nucleotide binding]; other site
370438003858	transcription elongation factor NusA; Provisional; Region: nusA; PRK12327
370438003859	NusA N-terminal domain; Region: NusA_N; pfam08529
370438003860	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
370438003861	RNA binding site [nucleotide binding]; other site
370438003862	homodimer interface [polypeptide binding]; other site
370438003863	NusA-like KH domain; Region: KH_5; pfam13184
370438003864	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
370438003865	G-X-X-G motif; other site
370438003866	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
370438003867	putative RNA binding cleft [nucleotide binding]; other site
370438003868	Ribosomal protein HS6-type (S12/L30/L7a) [Translation, ribosomal structure and biogenesis]; Region: RPL8A; COG1358
370438003869	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
370438003870	translation initiation factor IF-2; Validated; Region: infB; PRK05306
370438003871	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
370438003872	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
370438003873	G1 box; other site
370438003874	putative GEF interaction site [polypeptide binding]; other site
370438003875	GTP/Mg2+ binding site [chemical binding]; other site
370438003876	Switch I region; other site
370438003877	G2 box; other site
370438003878	G3 box; other site
370438003879	Switch II region; other site
370438003880	G4 box; other site
370438003881	G5 box; other site
370438003882	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
370438003883	Translation-initiation factor 2; Region: IF-2; pfam11987
370438003884	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
370438003885	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
370438003886	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
370438003887	DHH family; Region: DHH; pfam01368
370438003888	DHHA1 domain; Region: DHHA1; pfam02272
370438003889	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130
370438003890	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
370438003891	RNA binding site [nucleotide binding]; other site
370438003892	active site
370438003893	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
370438003894	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
370438003895	active site
370438003896	Riboflavin kinase; Region: Flavokinase; pfam01687
370438003897	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
370438003898	16S/18S rRNA binding site [nucleotide binding]; other site
370438003899	S13e-L30e interaction site [polypeptide binding]; other site
370438003900	25S rRNA binding site [nucleotide binding]; other site
370438003901	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
370438003902	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
370438003903	RNase E interface [polypeptide binding]; other site
370438003904	trimer interface [polypeptide binding]; other site
370438003905	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
370438003906	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
370438003907	RNase E interface [polypeptide binding]; other site
370438003908	trimer interface [polypeptide binding]; other site
370438003909	active site
370438003910	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
370438003911	putative nucleic acid binding region [nucleotide binding]; other site
370438003912	G-X-X-G motif; other site
370438003913	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
370438003914	RNA binding site [nucleotide binding]; other site
370438003915	domain interface; other site
370438003916	Putative catalytic NodB homology domain of uncharacterized protein YlxY from Bacillus subtilis and its bacterial homologs; Region: CE4_BsYlxY_like; cd10950
370438003917	NodB motif; other site
370438003918	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
370438003919	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
370438003920	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
370438003921	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
370438003922	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
370438003923	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
370438003924	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
370438003925	trimer interface [polypeptide binding]; other site
370438003926	active site
370438003927	sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888
370438003928	Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972
370438003929	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
370438003930	active site
370438003931	dihydrodipicolinate reductase; Provisional; Region: PRK00048
370438003932	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
370438003933	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
370438003934	dipicolinate synthase subunit A; Reviewed; Region: PRK08306
370438003935	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
370438003936	NAD binding site [chemical binding]; other site
370438003937	dipicolinate synthase subunit B; Reviewed; Region: spoVFB; PRK08305
370438003938	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
370438003939	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
370438003940	aspartate kinase I; Reviewed; Region: PRK08210
370438003941	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
370438003942	nucleotide binding site [chemical binding]; other site
370438003943	substrate binding site [chemical binding]; other site
370438003944	ACT domains of the diaminopimelate-sensitive aspartokinase (AK) isoenzyme AKI; Region: ACT_AKi-DapG-BS_1; cd04914
370438003945	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
370438003946	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
370438003947	dihydrodipicolinate synthase; Region: dapA; TIGR00674
370438003948	dimer interface [polypeptide binding]; other site
370438003949	active site
370438003950	catalytic residue [active]
370438003951	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
370438003952	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
370438003953	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
370438003954	Clp protease; Region: CLP_protease; pfam00574
370438003955	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
370438003956	active site
370438003957	YlzJ-like protein; Region: YlzJ; pfam14035
370438003958	Bacitracin resistance protein BacA; Region: BacA; pfam02673
370438003959	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
370438003960	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
370438003961	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
370438003962	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
370438003963	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
370438003964	active site residue [active]
370438003965	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
370438003966	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
370438003967	non-specific DNA binding site [nucleotide binding]; other site
370438003968	salt bridge; other site
370438003969	sequence-specific DNA binding site [nucleotide binding]; other site
370438003970	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
370438003971	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
370438003972	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
370438003973	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370438003974	FeS/SAM binding site; other site
370438003975	TRAM domain; Region: TRAM; cl01282
370438003976	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
370438003977	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
370438003978	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438003979	Walker A motif; other site
370438003980	ATP binding site [chemical binding]; other site
370438003981	Walker B motif; other site
370438003982	arginine finger; other site
370438003983	Peptidase family M41; Region: Peptidase_M41; pfam01434
370438003984	competence damage-inducible protein A; Provisional; Region: PRK00549
370438003985	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
370438003986	putative MPT binding site; other site
370438003987	Competence-damaged protein; Region: CinA; pfam02464
370438003988	recombinase A; Provisional; Region: recA; PRK09354
370438003989	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
370438003990	hexamer interface [polypeptide binding]; other site
370438003991	Walker A motif; other site
370438003992	ATP binding site [chemical binding]; other site
370438003993	Walker B motif; other site
370438003994	Domain of unknown function (DUF3552); Region: DUF3552; pfam12072
370438003995	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
370438003996	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
370438003997	Zn2+ binding site [ion binding]; other site
370438003998	Mg2+ binding site [ion binding]; other site
370438003999	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
370438004000	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
370438004001	putative active site [active]
370438004002	metal binding site [ion binding]; metal-binding site
370438004003	homodimer binding site [polypeptide binding]; other site
370438004004	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
370438004005	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
370438004006	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
370438004007	active site
370438004008	dimer interface [polypeptide binding]; other site
370438004009	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
370438004010	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
370438004011	active site
370438004012	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
370438004013	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
370438004014	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
370438004015	pyridoxal 5'-phosphate binding site [chemical binding]; other site
370438004016	homodimer interface [polypeptide binding]; other site
370438004017	catalytic residue [active]
370438004018	proteasome-activating nucleotidase; Provisional; Region: PRK03992
370438004019	Domain of unknown function (DUF3842); Region: DUF3842; pfam12953
370438004020	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
370438004021	homotrimer interface [polypeptide binding]; other site
370438004022	Walker A motif; other site
370438004023	GTP binding site [chemical binding]; other site
370438004024	Walker B motif; other site
370438004025	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
370438004026	cobalamin synthase; Reviewed; Region: cobS; PRK00235
370438004027	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
370438004028	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
370438004029	pyridoxal 5'-phosphate binding site [chemical binding]; other site
370438004030	homodimer interface [polypeptide binding]; other site
370438004031	catalytic residue [active]
370438004032	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
370438004033	catalytic core [active]
370438004034	SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320
370438004035	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
370438004036	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
370438004037	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
370438004038	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
370438004039	active site
370438004040	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
370438004041	Coenzyme A binding pocket [chemical binding]; other site
370438004042	conserved hypothetical protein; Region: TIGR02231
370438004043	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
370438004044	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
370438004045	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
370438004046	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
370438004047	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
370438004048	catalytic residue [active]
370438004049	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
370438004050	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
370438004051	Walker A motif; other site
370438004052	homodimer interface [polypeptide binding]; other site
370438004053	ATP binding site [chemical binding]; other site
370438004054	hydroxycobalamin binding site [chemical binding]; other site
370438004055	Walker B motif; other site
370438004056	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
370438004057	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
370438004058	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
370438004059	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989
370438004060	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
370438004061	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
370438004062	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
370438004063	putative dimer interface [polypeptide binding]; other site
370438004064	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
370438004065	dimer interface [polypeptide binding]; other site
370438004066	active site
370438004067	ADP-ribose binding site [chemical binding]; other site
370438004068	nudix motif; other site
370438004069	metal binding site [ion binding]; metal-binding site
370438004070	septum formation inhibitor; Reviewed; Region: minC; PRK00513
370438004071	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
370438004072	ADP-glucose phosphorylase; Region: PLN02643
370438004073	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
370438004074	nucleotide binding site/active site [active]
370438004075	HIT family signature motif; other site
370438004076	catalytic residue [active]
370438004077	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
370438004078	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
370438004079	Domain of unknown function (DUF362); Region: DUF362; pfam04015
370438004080	Asp23 family; Region: Asp23; pfam03780
370438004081	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
370438004082	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
370438004083	Ligand Binding Site [chemical binding]; other site
370438004084	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14328
370438004085	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
370438004086	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370438004087	FeS/SAM binding site; other site
370438004088	TRAM domain; Region: TRAM; pfam01938
370438004089	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
370438004090	MutS domain I; Region: MutS_I; pfam01624
370438004091	MutS domain II; Region: MutS_II; pfam05188
370438004092	MutS domain III; Region: MutS_III; pfam05192
370438004093	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
370438004094	Walker A/P-loop; other site
370438004095	ATP binding site [chemical binding]; other site
370438004096	Q-loop/lid; other site
370438004097	ABC transporter signature motif; other site
370438004098	Walker B; other site
370438004099	D-loop; other site
370438004100	H-loop/switch region; other site
370438004101	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
370438004102	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
370438004103	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
370438004104	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
370438004105	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
370438004106	active site
370438004107	Zn binding site [ion binding]; other site
370438004108	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
370438004109	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
370438004110	ATP binding site [chemical binding]; other site
370438004111	Mg2+ binding site [ion binding]; other site
370438004112	G-X-G motif; other site
370438004113	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
370438004114	ATP binding site [chemical binding]; other site
370438004115	MutL C terminal dimerisation domain; Region: MutL_C; smart00853
370438004116	Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517
370438004117	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
370438004118	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
370438004119	bacterial Hfq-like; Region: Hfq; cd01716
370438004120	hexamer interface [polypeptide binding]; other site
370438004121	Sm1 motif; other site
370438004122	RNA binding site [nucleotide binding]; other site
370438004123	Sm2 motif; other site
370438004124	stage V sporulation protein K; Region: spore_V_K; TIGR02881
370438004125	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438004126	Walker A motif; other site
370438004127	ATP binding site [chemical binding]; other site
370438004128	Walker B motif; other site
370438004129	arginine finger; other site
370438004130	Cystathionine beta-lyase family protein involved in aluminum resistance [Inorganic ion transport and metabolism]; Region: COG4100
370438004131	Aluminium resistance protein; Region: Alum_res; pfam06838
370438004132	Transcriptional regulator [Transcription]; Region: LysR; COG0583
370438004133	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
370438004134	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
370438004135	putative dimerization interface [polypeptide binding]; other site
370438004136	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
370438004137	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
370438004138	putative active site [active]
370438004139	heme pocket [chemical binding]; other site
370438004140	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
370438004141	ATP binding site [chemical binding]; other site
370438004142	Mg2+ binding site [ion binding]; other site
370438004143	G-X-G motif; other site
370438004144	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
370438004145	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370438004146	active site
370438004147	phosphorylation site [posttranslational modification]
370438004148	intermolecular recognition site; other site
370438004149	dimerization interface [polypeptide binding]; other site
370438004150	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
370438004151	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
370438004152	Transposase, Mutator family; Region: Transposase_mut; pfam00872
370438004153	MULE transposase domain; Region: MULE; pfam10551
370438004154	LexA repressor; Validated; Region: PRK00215
370438004155	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
370438004156	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
370438004157	Catalytic site [active]
370438004158	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
370438004159	Transposase domain (DUF772); Region: DUF772; pfam05598
370438004160	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
370438004161	putative CheW interface [polypeptide binding]; other site
370438004162	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
370438004163	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
370438004164	PAS fold; Region: PAS; pfam00989
370438004165	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
370438004166	putative active site [active]
370438004167	heme pocket [chemical binding]; other site
370438004168	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438004169	phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608
370438004170	Walker A motif; other site
370438004171	ATP binding site [chemical binding]; other site
370438004172	Walker B motif; other site
370438004173	arginine finger; other site
370438004174	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
370438004175	fumarate hydratase; Provisional; Region: PRK06246
370438004176	Fumarase C-terminus; Region: Fumerase_C; cl00795
370438004177	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
370438004178	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
370438004179	CoA-ligase; Region: Ligase_CoA; pfam00549
370438004180	CoA binding domain; Region: CoA_binding; pfam02629
370438004181	CoA-ligase; Region: Ligase_CoA; pfam00549
370438004182	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680
370438004183	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
370438004184	B12 binding site [chemical binding]; other site
370438004185	cobalt ligand [ion binding]; other site
370438004186	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
370438004187	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
370438004188	dimer interface [polypeptide binding]; other site
370438004189	substrate binding site [chemical binding]; other site
370438004190	metal binding site [ion binding]; metal-binding site
370438004191	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
370438004192	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
370438004193	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
370438004194	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
370438004195	carboxyltransferase (CT) interaction site; other site
370438004196	biotinylation site [posttranslational modification]; other site
370438004197	malate dehydrogenase; Reviewed; Region: PRK06223
370438004198	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
370438004199	NAD(P) binding site [chemical binding]; other site
370438004200	dimer interface [polypeptide binding]; other site
370438004201	tetramer (dimer of dimers) interface [polypeptide binding]; other site
370438004202	substrate binding site [chemical binding]; other site
370438004203	Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016
370438004204	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
370438004205	active site
370438004206	catalytic residues [active]
370438004207	metal binding site [ion binding]; metal-binding site
370438004208	homodimer binding site [polypeptide binding]; other site
370438004209	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
370438004210	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
370438004211	dimer interface [polypeptide binding]; other site
370438004212	PYR/PP interface [polypeptide binding]; other site
370438004213	TPP binding site [chemical binding]; other site
370438004214	substrate binding site [chemical binding]; other site
370438004215	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
370438004216	Domain of unknown function; Region: EKR; smart00890
370438004217	4Fe-4S binding domain; Region: Fer4_6; pfam12837
370438004218	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
370438004219	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
370438004220	TPP-binding site [chemical binding]; other site
370438004221	dimer interface [polypeptide binding]; other site
370438004222	Zinc dependent phospholipase C (alpha toxin); Region: Zn_dep_PLPC; cd11009
370438004223	Zn binding site [ion binding]; other site
370438004224	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
370438004225	Major Facilitator Superfamily; Region: MFS_1; pfam07690
370438004226	putative substrate translocation pore; other site
370438004227	ABC-2 type transporter; Region: ABC2_membrane; cl17235
370438004228	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
370438004229	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
370438004230	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
370438004231	Walker A/P-loop; other site
370438004232	ATP binding site [chemical binding]; other site
370438004233	Q-loop/lid; other site
370438004234	ABC transporter signature motif; other site
370438004235	Walker B; other site
370438004236	D-loop; other site
370438004237	H-loop/switch region; other site
370438004238	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
370438004239	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
370438004240	acyl-activating enzyme (AAE) consensus motif; other site
370438004241	putative AMP binding site [chemical binding]; other site
370438004242	putative active site [active]
370438004243	putative CoA binding site [chemical binding]; other site
370438004244	bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569
370438004245	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
370438004246	catalytic loop [active]
370438004247	iron binding site [ion binding]; other site
370438004248	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
370438004249	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
370438004250	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
370438004251	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
370438004252	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
370438004253	dimer interface [polypeptide binding]; other site
370438004254	[2Fe-2S] cluster binding site [ion binding]; other site
370438004255	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
370438004256	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
370438004257	4Fe-4S binding domain; Region: Fer4; pfam00037
370438004258	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
370438004259	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
370438004260	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
370438004261	putative dimer interface [polypeptide binding]; other site
370438004262	[2Fe-2S] cluster binding site [ion binding]; other site
370438004263	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
370438004264	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
370438004265	ABC-ATPase subunit  interface; other site
370438004266	dimer interface [polypeptide binding]; other site
370438004267	putative PBP binding regions; other site
370438004268	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
370438004269	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
370438004270	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
370438004271	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
370438004272	metal binding site [ion binding]; metal-binding site
370438004273	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
370438004274	metal binding site 2 [ion binding]; metal-binding site
370438004275	putative DNA binding helix; other site
370438004276	metal binding site 1 [ion binding]; metal-binding site
370438004277	dimer interface [polypeptide binding]; other site
370438004278	structural Zn2+ binding site [ion binding]; other site
370438004279	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
370438004280	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
370438004281	putative ADP-binding pocket [chemical binding]; other site
370438004282	Soluble P-type ATPase [General function prediction only]; Region: COG4087
370438004283	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
370438004284	phosphofructokinase; Region: PFK_mixed; TIGR02483
370438004285	active site
370438004286	ADP/pyrophosphate binding site [chemical binding]; other site
370438004287	dimerization interface [polypeptide binding]; other site
370438004288	allosteric effector site; other site
370438004289	fructose-1,6-bisphosphate binding site; other site
370438004290	Uncharacterized conserved protein [Function unknown]; Region: COG1615
370438004291	Uncharacterized protein family (UPF0182); Region: UPF0182; pfam03699
370438004292	Transposase, Mutator family; Region: Transposase_mut; pfam00872
370438004293	MULE transposase domain; Region: MULE; pfam10551
370438004294	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
370438004295	intersubunit interface [polypeptide binding]; other site
370438004296	active site
370438004297	catalytic residue [active]
370438004298	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
370438004299	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
370438004300	Domain of unknown function (DUF4374); Region: DUF4374; pfam14298
370438004301	ATP-grasp domain; Region: ATP-grasp_4; cl17255
370438004302	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
370438004303	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
370438004304	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
370438004305	active site
370438004306	catalytic residues [active]
370438004307	DNA binding site [nucleotide binding]
370438004308	Int/Topo IB signature motif; other site
370438004309	Homeodomain-like domain; Region: HTH_23; pfam13384
370438004310	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
370438004311	polymerase nucleotide-binding site; other site
370438004312	DNA-binding residues [nucleotide binding]; DNA binding site
370438004313	nucleotide binding site [chemical binding]; other site
370438004314	primase nucleotide-binding site [nucleotide binding]; other site
370438004315	Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942
370438004316	AAA domain; Region: AAA_25; pfam13481
370438004317	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cd01120
370438004318	ATP binding site [chemical binding]; other site
370438004319	Walker B motif; other site
370438004320	Elongation factor G (EF-G) family; Region: EF-G_bact; cd04170
370438004321	elongation factor G; Reviewed; Region: PRK12740
370438004322	G1 box; other site
370438004323	putative GEF interaction site [polypeptide binding]; other site
370438004324	GTP/Mg2+ binding site [chemical binding]; other site
370438004325	Switch I region; other site
370438004326	G2 box; other site
370438004327	G3 box; other site
370438004328	Switch II region; other site
370438004329	G4 box; other site
370438004330	G5 box; other site
370438004331	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
370438004332	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
370438004333	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
370438004334	stage V sporulation protein B; Region: spore_V_B; TIGR02900
370438004335	Stage V sporulation protein B, also known as Stage III sporulation protein F, and related proteins; Region: MATE_SpoVB_like; cd13124
370438004336	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
370438004337	Protein of unknown function (DUF4264); Region: DUF4264; pfam14084
370438004338	GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate.  The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria.  In...; Region: GTP_cyclohydro1; cd00642
370438004339	homodecamer interface [polypeptide binding]; other site
370438004340	GTP cyclohydrolase I; Provisional; Region: PLN03044
370438004341	active site
370438004342	putative catalytic site residues [active]
370438004343	zinc binding site [ion binding]; other site
370438004344	GTP-CH-I/GFRP interaction surface; other site
370438004345	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
370438004346	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
370438004347	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370438004348	FeS/SAM binding site; other site
370438004349	Domain of unknown function (DUF366); Region: DUF366; pfam04017
370438004350	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
370438004351	Ligand Binding Site [chemical binding]; other site
370438004352	6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242
370438004353	active site
370438004354	Protein of unknown function (DUF3792); Region: DUF3792; pfam12670
370438004355	cytochrome-c3 hydrogenase subunit gamma; Provisional; Region: PRK08345
370438004356	Anaerobic sulfite reductase contains an FAD and NADPH binding module with structural similarity to ferredoxin reductase and sequence similarity to dihydroorotate dehydrogenases. Clostridium pasteurianum inducible dissimilatory type sulfite reductase is...; Region: sulfite_reductase_like; cd06221
370438004357	FAD binding pocket [chemical binding]; other site
370438004358	FAD binding motif [chemical binding]; other site
370438004359	phosphate binding motif [ion binding]; other site
370438004360	beta-alpha-beta structure motif; other site
370438004361	NAD binding pocket [chemical binding]; other site
370438004362	Iron coordination center [ion binding]; other site
370438004363	anaerobic sulfite reductase subunit A; Provisional; Region: PRK15055
370438004364	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
370438004365	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
370438004366	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
370438004367	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; cl00831
370438004368	Methyl-viologen-reducing hydrogenase, delta subunit; Region: FlpD; pfam02662
370438004369	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
370438004370	Heterodisulfide reductase, subunit A and related polyferredoxins [Energy production and conversion]; Region: HdrA; COG1148
370438004371	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
370438004372	Heterodisulfide reductase, subunit B [Energy production and conversion]; Region: HdrB; COG2048
370438004373	Cysteine-rich domain; Region: CCG; pfam02754
370438004374	Cysteine-rich domain; Region: CCG; pfam02754
370438004375	4Fe-4S dicluster domain; Region: Fer4_17; pfam13534
370438004376	bifunctional ATP-dependent DNA helicase/DNA polymerase III subunit epsilon; Validated; Region: PRK08074
370438004377	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
370438004378	active site
370438004379	catalytic site [active]
370438004380	substrate binding site [chemical binding]; other site
370438004381	CRISPR/Cas system-associated DinG family helicase Csf4; Region: Csf4_U; cl17460
370438004382	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
370438004383	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
370438004384	metal-dependent hydrolase; Provisional; Region: PRK00685
370438004385	Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
370438004386	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
370438004387	Walker A; other site
370438004388	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
370438004389	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
370438004390	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
370438004391	adenylate kinase; Reviewed; Region: adk; PRK00279
370438004392	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
370438004393	AMP-binding site [chemical binding]; other site
370438004394	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
370438004395	Family description; Region: VCBS; pfam13517
370438004396	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
370438004397	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
370438004398	putative dimer interface [polypeptide binding]; other site
370438004399	putative anticodon binding site; other site
370438004400	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
370438004401	homodimer interface [polypeptide binding]; other site
370438004402	motif 1; other site
370438004403	motif 2; other site
370438004404	active site
370438004405	motif 3; other site
370438004406	aspartate aminotransferase; Provisional; Region: PRK06836
370438004407	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
370438004408	pyridoxal 5'-phosphate binding site [chemical binding]; other site
370438004409	homodimer interface [polypeptide binding]; other site
370438004410	catalytic residue [active]
370438004411	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
370438004412	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
370438004413	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
370438004414	putative active site [active]
370438004415	heme pocket [chemical binding]; other site
370438004416	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
370438004417	putative active site [active]
370438004418	heme pocket [chemical binding]; other site
370438004419	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
370438004420	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
370438004421	putative active site [active]
370438004422	heme pocket [chemical binding]; other site
370438004423	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
370438004424	dimer interface [polypeptide binding]; other site
370438004425	phosphorylation site [posttranslational modification]
370438004426	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
370438004427	ATP binding site [chemical binding]; other site
370438004428	Mg2+ binding site [ion binding]; other site
370438004429	G-X-G motif; other site
370438004430	Protein of unknown function (DUF456); Region: DUF456; pfam04306
370438004431	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
370438004432	S-adenosylmethionine binding site [chemical binding]; other site
370438004433	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
370438004434	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
370438004435	active site
370438004436	metal binding site [ion binding]; metal-binding site
370438004437	selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512
370438004438	SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171
370438004439	G1 box; other site
370438004440	putative GEF interaction site [polypeptide binding]; other site
370438004441	GTP/Mg2+ binding site [chemical binding]; other site
370438004442	Switch I region; other site
370438004443	G2 box; other site
370438004444	G3 box; other site
370438004445	Switch II region; other site
370438004446	G4 box; other site
370438004447	G5 box; other site
370438004448	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
370438004449	This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094
370438004450	Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106
370438004451	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
370438004452	selenocysteine synthase; Provisional; Region: PRK04311
370438004453	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
370438004454	Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921
370438004455	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
370438004456	catalytic residue [active]
370438004457	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789
370438004458	Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046
370438004459	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
370438004460	dimerization interface [polypeptide binding]; other site
370438004461	ATP binding site [chemical binding]; other site
370438004462	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
370438004463	dimerization interface [polypeptide binding]; other site
370438004464	ATP binding site [chemical binding]; other site
370438004465	CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507
370438004466	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
370438004467	putative active site [active]
370438004468	catalytic triad [active]
370438004469	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
370438004470	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
370438004471	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
370438004472	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
370438004473	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
370438004474	active site
370438004475	DNA binding site [nucleotide binding]
370438004476	Int/Topo IB signature motif; other site
370438004477	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
370438004478	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
370438004479	active site
370438004480	DNA binding site [nucleotide binding]
370438004481	Int/Topo IB signature motif; other site
370438004482	Transposase, Mutator family; Region: Transposase_mut; pfam00872
370438004483	MULE transposase domain; Region: MULE; pfam10551
370438004484	Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621
370438004485	4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337
370438004486	UbiA prenyltransferase family; Region: UbiA; pfam01040
370438004487	menaquinone biosynthesis decarboxylase, SCO4490 family; Region: mena_SCO4490; TIGR03701
370438004488	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
370438004489	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
370438004490	S-adenosylmethionine binding site [chemical binding]; other site
370438004491	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
370438004492	substrate binding pocket [chemical binding]; other site
370438004493	aspartate-rich region 1; other site
370438004494	S-adenosylmethionine decarboxylase proenzyme; Provisional; Region: PRK03124
370438004495	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
370438004496	Sensor protein DegS; Region: DegS; pfam05384
370438004497	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585
370438004498	Histidine kinase; Region: HisKA_3; pfam07730
370438004499	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
370438004500	ATP binding site [chemical binding]; other site
370438004501	Mg2+ binding site [ion binding]; other site
370438004502	G-X-G motif; other site
370438004503	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
370438004504	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370438004505	active site
370438004506	phosphorylation site [posttranslational modification]
370438004507	intermolecular recognition site; other site
370438004508	dimerization interface [polypeptide binding]; other site
370438004509	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
370438004510	DNA binding residues [nucleotide binding]
370438004511	dimerization interface [polypeptide binding]; other site
370438004512	Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847
370438004513	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
370438004514	TadE-like protein; Region: TadE; pfam07811
370438004515	Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977
370438004516	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
370438004517	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
370438004518	Response regulator receiver domain; Region: Response_reg; pfam00072
370438004519	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370438004520	active site
370438004521	phosphorylation site [posttranslational modification]
370438004522	intermolecular recognition site; other site
370438004523	dimerization interface [polypeptide binding]; other site
370438004524	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
370438004525	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
370438004526	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
370438004527	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
370438004528	ATP binding site [chemical binding]; other site
370438004529	Walker A motif; other site
370438004530	hexamer interface [polypeptide binding]; other site
370438004531	Walker B motif; other site
370438004532	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
370438004533	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
370438004534	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
370438004535	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
370438004536	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
370438004537	sensor protein ZraS; Provisional; Region: PRK10364
370438004538	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
370438004539	dimerization interface [polypeptide binding]; other site
370438004540	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
370438004541	Vegetative insecticide protein 3A N terminal; Region: Vip3A_N; pfam12495
370438004542	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
370438004543	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
370438004544	FtsX-like permease family; Region: FtsX; pfam02687
370438004545	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
370438004546	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
370438004547	Walker A/P-loop; other site
370438004548	ATP binding site [chemical binding]; other site
370438004549	Q-loop/lid; other site
370438004550	ABC transporter signature motif; other site
370438004551	Walker B; other site
370438004552	D-loop; other site
370438004553	H-loop/switch region; other site
370438004554	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
370438004555	HlyD family secretion protein; Region: HlyD_3; pfam13437
370438004556	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
370438004557	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
370438004558	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
370438004559	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
370438004560	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
370438004561	motif II; other site
370438004562	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
370438004563	Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326
370438004564	SpoOM protein; Region: Spo0M; pfam07070
370438004565	Methyltransferase domain; Region: Methyltransf_31; pfam13847
370438004566	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
370438004567	S-adenosylmethionine binding site [chemical binding]; other site
370438004568	TrkA-C domain; Region: TrkA_C; pfam02080
370438004569	Ion channel; Region: Ion_trans_2; pfam07885
370438004570	TrkA-N domain; Region: TrkA_N; pfam02254
370438004571	Mannosyltransferase (PIG-V)); Region: Mannosyl_trans2; pfam04188
370438004572	Predicted membrane protein [Function unknown]; Region: COG2246
370438004573	GtrA-like protein; Region: GtrA; pfam04138
370438004574	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
370438004575	Ligand binding site; other site
370438004576	Putative Catalytic site; other site
370438004577	DXD motif; other site
370438004578	Transposase, Mutator family; Region: Transposase_mut; pfam00872
370438004579	MULE transposase domain; Region: MULE; pfam10551
370438004580	Ubiquitin-like proteins; Region: UBQ; cl00155
370438004581	charged pocket; other site
370438004582	hydrophobic patch; other site
370438004583	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
370438004584	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
370438004585	non-specific DNA binding site [nucleotide binding]; other site
370438004586	salt bridge; other site
370438004587	sequence-specific DNA binding site [nucleotide binding]; other site
370438004588	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
370438004589	Catalytic site [active]
370438004590	Domain of unknown function DUF39; Region: DUF39; pfam01837
370438004591	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
370438004592	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
370438004593	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
370438004594	hypothetical protein; Provisional; Region: PRK04334
370438004595	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
370438004596	ABC-2 type transporter; Region: ABC2_membrane; cl17235
370438004597	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
370438004598	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
370438004599	Walker A/P-loop; other site
370438004600	ATP binding site [chemical binding]; other site
370438004601	Q-loop/lid; other site
370438004602	ABC transporter signature motif; other site
370438004603	Walker B; other site
370438004604	D-loop; other site
370438004605	H-loop/switch region; other site
370438004606	Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955
370438004607	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
370438004608	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
370438004609	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
370438004610	Q-loop/lid; other site
370438004611	ABC transporter signature motif; other site
370438004612	Walker B; other site
370438004613	D-loop; other site
370438004614	H-loop/switch region; other site
370438004615	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
370438004616	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
370438004617	Walker A/P-loop; other site
370438004618	ATP binding site [chemical binding]; other site
370438004619	Q-loop/lid; other site
370438004620	ABC transporter signature motif; other site
370438004621	Walker B; other site
370438004622	D-loop; other site
370438004623	H-loop/switch region; other site
370438004624	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
370438004625	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
370438004626	Prenyltransferase-like; Region: Prenyltrans_1; pfam13243
370438004627	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
370438004628	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
370438004629	This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688
370438004630	Prenyltransferase-like; Region: Prenyltrans_2; pfam13249
370438004631	S-layer homology domain; Region: SLH; pfam00395
370438004632	S-layer homology domain; Region: SLH; pfam00395
370438004633	S-layer homology domain; Region: SLH; pfam00395
370438004634	Formylmethanofuran dehydrogenase subunit E [Energy production and conversion]; Region: COG2191
370438004635	FmdE, Molybdenum formylmethanofuran dehydrogenase operon; Region: FmdE; pfam02663
370438004636	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; pfam01258
370438004637	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
370438004638	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
370438004639	Walker A/P-loop; other site
370438004640	ATP binding site [chemical binding]; other site
370438004641	Q-loop/lid; other site
370438004642	ABC transporter signature motif; other site
370438004643	Walker B; other site
370438004644	D-loop; other site
370438004645	H-loop/switch region; other site
370438004646	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
370438004647	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
370438004648	Walker A/P-loop; other site
370438004649	ATP binding site [chemical binding]; other site
370438004650	Q-loop/lid; other site
370438004651	ABC transporter signature motif; other site
370438004652	Walker B; other site
370438004653	D-loop; other site
370438004654	H-loop/switch region; other site
370438004655	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
370438004656	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
370438004657	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
370438004658	dimer interface [polypeptide binding]; other site
370438004659	ABC-ATPase subunit interface; other site
370438004660	putative PBP binding loops; other site
370438004661	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
370438004662	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
370438004663	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
370438004664	ABC-ATPase subunit interface; other site
370438004665	putative PBP binding loops; other site
370438004666	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
370438004667	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_21; cd08520
370438004668	Methyltransferase domain; Region: Methyltransf_31; pfam13847
370438004669	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
370438004670	S-adenosylmethionine binding site [chemical binding]; other site
370438004671	LytR cell envelope-related transcriptional attenuator; Region: LytR_C; pfam13399
370438004672	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
370438004673	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
370438004674	catalytic loop [active]
370438004675	iron binding site [ion binding]; other site
370438004676	succinate dehydrogenase or fumarate reductase, flavoprotein subunitGram-negative/mitochondrial subgroup; Region: sdhA_frdA_Gneg; TIGR01812
370438004677	L-aspartate oxidase; Provisional; Region: PRK06175
370438004678	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
370438004679	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
370438004680	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
370438004681	coenzyme F420-reducing hydrogenase subunit beta; Validated; Region: PRK09325
370438004682	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit N-term; Region: FrhB_FdhB_N; pfam04422
370438004683	Coenzyme F420 hydrogenase/dehydrogenase, beta subunit C terminus; Region: FrhB_FdhB_C; pfam04432
370438004684	MmgE/PrpD family; Region: MmgE_PrpD; cl00912
370438004685	Domain of unknown function (DUF4387); Region: DUF4387; pfam14330
370438004686	Protein of unknown function (DUF1446); Region: DUF1446; pfam07287
370438004687	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
370438004688	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
370438004689	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
370438004690	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
370438004691	DNA polymerase IV; Reviewed; Region: PRK03103
370438004692	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
370438004693	active site
370438004694	DNA binding site [nucleotide binding]
370438004695	Predicted integral membrane protein [Function unknown]; Region: COG5658
370438004696	Protein of unknown function (DUF1648); Region: DUF1648; pfam07853
370438004697	SdpI/YhfL protein family; Region: SdpI; pfam13630
370438004698	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
370438004699	dimerization interface [polypeptide binding]; other site
370438004700	putative DNA binding site [nucleotide binding]; other site
370438004701	putative Zn2+ binding site [ion binding]; other site
370438004702	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
370438004703	putative oxidoreductase; Provisional; Region: PRK12831
370438004704	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
370438004705	SirA_like_N, a protein of unknown function with an N-terminal SirA-like domain.  The SirA, YedF, YeeD protein family is present in bacteria as well as archaea. SirA (also known as UvrY,  and YhhP) belongs to a family of a two-component response...; Region: SirA_like_N; cd03421
370438004706	selenium metabolism protein YedF; Region: selenium_YedF; TIGR03527
370438004707	CPxP  motif; other site
370438004708	DsrE/DsrF-like family; Region: DrsE; pfam02635
370438004709	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
370438004710	Nitrite and sulphite reductase 4Fe-4S domain; Region: NIR_SIR; pfam01077
370438004711	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
370438004712	CoA binding domain; Region: CoA_binding_2; pfam13380
370438004713	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
370438004714	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
370438004715	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
370438004716	BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857
370438004717	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
370438004718	DRTGG domain; Region: DRTGG; pfam07085
370438004719	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
370438004720	CoenzymeA binding site [chemical binding]; other site
370438004721	subunit interaction site [polypeptide binding]; other site
370438004722	PHB binding site; other site
370438004723	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
370438004724	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
370438004725	Nitroreductase family; Region: Nitroreductase; pfam00881
370438004726	FMN binding site [chemical binding]; other site
370438004727	dimer interface [polypeptide binding]; other site
370438004728	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
370438004729	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
370438004730	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
370438004731	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
370438004732	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
370438004733	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
370438004734	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
370438004735	Walker A/P-loop; other site
370438004736	ATP binding site [chemical binding]; other site
370438004737	Q-loop/lid; other site
370438004738	ABC transporter signature motif; other site
370438004739	Walker B; other site
370438004740	D-loop; other site
370438004741	H-loop/switch region; other site
370438004742	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
370438004743	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
370438004744	Walker A/P-loop; other site
370438004745	ATP binding site [chemical binding]; other site
370438004746	Q-loop/lid; other site
370438004747	ABC transporter signature motif; other site
370438004748	Walker B; other site
370438004749	D-loop; other site
370438004750	H-loop/switch region; other site
370438004751	Domain of unknown function (DUF4162); Region: DUF4162; pfam13732
370438004752	putative efflux pump membrane fusion protein; Provisional; Region: PRK03598
370438004753	HlyD family secretion protein; Region: HlyD_3; pfam13437
370438004754	Predicted RNA-binding protein, contains TRAM domain [General function prediction only]; Region: COG3269
370438004755	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
370438004756	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
370438004757	S-adenosylmethionine binding site [chemical binding]; other site
370438004758	DDE superfamily endonuclease; Region: DDE_5; cl17874
370438004759	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
370438004760	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
370438004761	ABC transporter; Region: ABC_tran_2; pfam12848
370438004762	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
370438004763	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
370438004764	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708
370438004765	Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189
370438004766	DNA methylase; Region: N6_N4_Mtase; pfam01555
370438004767	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
370438004768	Integrase core domain; Region: rve; pfam00665
370438004769	DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484
370438004770	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
370438004771	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
370438004772	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
370438004773	Ligand binding site; other site
370438004774	metal-binding site
370438004775	probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172
370438004776	selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309
370438004777	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
370438004778	XdhC Rossmann domain; Region: XdhC_C; pfam13478
370438004779	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
370438004780	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
370438004781	putative MPT binding site; other site
370438004782	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
370438004783	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
370438004784	transmembrane helices; other site
370438004785	4-hydroxybenzoyl-CoA reductase, alpha subunit; Region: 4hydrxCoA_A; TIGR03194
370438004786	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
370438004787	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
370438004788	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
370438004789	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
370438004790	catalytic loop [active]
370438004791	iron binding site [ion binding]; other site
370438004792	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
370438004793	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
370438004794	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
370438004795	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
370438004796	Coenzyme A transferase; Region: CoA_trans; smart00882
370438004797	Coenzyme A transferase; Region: CoA_trans; cl17247
370438004798	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
370438004799	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
370438004800	transmembrane helices; other site
370438004801	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
370438004802	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
370438004803	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438004804	Walker A motif; other site
370438004805	ATP binding site [chemical binding]; other site
370438004806	Walker B motif; other site
370438004807	arginine finger; other site
370438004808	benzoate-CoA ligase family; Region: benz_CoA_lig; TIGR02262
370438004809	Benzoate CoA ligase (BCL) and 4-Hydroxybenzoate-Coenzyme A Ligase (4-HBA-CoA ligase); Region: BCL_4HBCL; cd05959
370438004810	dimer interface [polypeptide binding]; other site
370438004811	acyl-activating enzyme (AAE) consensus motif; other site
370438004812	putative active site [active]
370438004813	putative AMP binding site [chemical binding]; other site
370438004814	putative CoA binding site [chemical binding]; other site
370438004815	chemical substrate binding site [chemical binding]; other site
370438004816	Transcriptional regulator [Transcription]; Region: LysR; COG0583
370438004817	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
370438004818	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
370438004819	dimerization interface [polypeptide binding]; other site
370438004820	Protein of unknown function (DUF2889); Region: DUF2889; pfam11136
370438004821	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
370438004822	AMP-binding domain protein; Validated; Region: PRK08315
370438004823	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917
370438004824	acyl-activating enzyme (AAE) consensus motif; other site
370438004825	putative AMP binding site [chemical binding]; other site
370438004826	putative active site [active]
370438004827	putative CoA binding site [chemical binding]; other site
370438004828	selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309
370438004829	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
370438004830	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
370438004831	putative MPT binding site; other site
370438004832	Predicted transcriptional regulators [Transcription]; Region: COG1695
370438004833	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
370438004834	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
370438004835	Ligand binding site [chemical binding]; other site
370438004836	Electron transfer flavoprotein domain; Region: ETF; pfam01012
370438004837	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
370438004838	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
370438004839	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
370438004840	Nitrate reductase gamma subunit; Region: Nitrate_red_gam; cl00959
370438004841	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
370438004842	Cysteine-rich domain; Region: CCG; pfam02754
370438004843	Cysteine-rich domain; Region: CCG; pfam02754
370438004844	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
370438004845	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370438004846	FeS/SAM binding site; other site
370438004847	Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251
370438004848	DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595
370438004849	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
370438004850	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
370438004851	DNA binding residues [nucleotide binding]
370438004852	Domain of unknown function (DUF4367); Region: DUF4367; pfam14285
370438004853	Winged helix-turn helix; Region: HTH_29; pfam13551
370438004854	Homeodomain-like domain; Region: HTH_32; pfam13565
370438004855	Integrase core domain; Region: rve; pfam00665
370438004856	Integrase core domain; Region: rve_3; pfam13683
370438004857	Transposase, Mutator family; Region: Transposase_mut; pfam00872
370438004858	MULE transposase domain; Region: MULE; pfam10551
370438004859	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
370438004860	HTH-like domain; Region: HTH_21; pfam13276
370438004861	Integrase core domain; Region: rve; pfam00665
370438004862	Integrase core domain; Region: rve_3; pfam13683
370438004863	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
370438004864	Transposase; Region: HTH_Tnp_1; pfam01527
370438004865	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
370438004866	Transposase; Region: HTH_Tnp_1; cl17663
370438004867	HTH-like domain; Region: HTH_21; pfam13276
370438004868	Integrase core domain; Region: rve; pfam00665
370438004869	Integrase core domain; Region: rve_3; pfam13683
370438004870	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
370438004871	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
370438004872	active site
370438004873	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
370438004874	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
370438004875	putative substrate translocation pore; other site
370438004876	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
370438004877	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
370438004878	active site
370438004879	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
370438004880	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
370438004881	active site
370438004882	Coenzyme A transferase; Region: CoA_trans; smart00882
370438004883	Coenzyme A transferase; Region: CoA_trans; cl17247
370438004884	4-hydroxybenzoyl-CoA reductase, alpha subunit; Region: 4hydrxCoA_A; TIGR03194
370438004885	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
370438004886	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
370438004887	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
370438004888	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
370438004889	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
370438004890	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
370438004891	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
370438004892	Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139
370438004893	hypothetical protein; Reviewed; Region: PRK09588
370438004894	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
370438004895	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
370438004896	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
370438004897	putative catalytic cysteine [active]
370438004898	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
370438004899	putative active site [active]
370438004900	metal binding site [ion binding]; metal-binding site
370438004901	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
370438004902	N-terminal Early set domain associated with the catalytic domain of Maltooligosyl trehalose trehalohydrolase (also called Glycosyltrehalose trehalohydrolase) and similar proteins; Region: E_set_MTHase_like_N; cd02853
370438004903	malto-oligosyltrehalose trehalohydrolase; Region: trehalose_TreZ; TIGR02402
370438004904	Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325
370438004905	catalytic site [active]
370438004906	active site
370438004907	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
370438004908	N-terminal putative catalytic domain of mainly uncharacterized prokaryotic proteins similar to archaeal thermoactive amylopullulanases; glycoside hydrolase family 57 (GH57); Region: GH57N_APU_like_1; cd10797
370438004909	Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065
370438004910	active site
370438004911	catalytic site [active]
370438004912	Domain of unknown function (DUF3536); Region: DUF3536; pfam12055
370438004913	maltooligosyl trehalose synthase; Provisional; Region: PRK14511
370438004914	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
370438004915	Alpha amylase catalytic domain found in maltooligosyl trehalose synthase (MTSase); Region: AmyAc_MTSase; cd11336
370438004916	active site
370438004917	catalytic site [active]
370438004918	Trehalose phosphorylase (TP) reversibly catalyzes trehalose synthesis and degradation from alpha-glucose-1-phosphate (alpha-Glc-1-P) and glucose. The catalyzing activity includes the phosphorolysis of trehalose, which produce alpha-Glc-1-P and glucose; Region: GT1_Trehalose_phosphorylase; cd03792
370438004919	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
370438004920	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
370438004921	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
370438004922	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
370438004923	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
370438004924	active site
370438004925	dimer interface [polypeptide binding]; other site
370438004926	effector binding site; other site
370438004927	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
370438004928	response regulator;containing CheY-like receiver domain and AraC-type DNA-binding domain; interrupted by transposase
370438004929	Transposase [DNA replication, recombination, and repair]; Region: COG5421
370438004930	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
370438004931	GAF domain; Region: GAF_3; pfam13492
370438004932	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
370438004933	Zn2+ binding site [ion binding]; other site
370438004934	Mg2+ binding site [ion binding]; other site
370438004935	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
370438004936	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
370438004937	dimer interface [polypeptide binding]; other site
370438004938	phosphorylation site [posttranslational modification]
370438004939	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
370438004940	ATP binding site [chemical binding]; other site
370438004941	Mg2+ binding site [ion binding]; other site
370438004942	G-X-G motif; other site
370438004943	Response regulator receiver domain; Region: Response_reg; pfam00072
370438004944	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370438004945	active site
370438004946	phosphorylation site [posttranslational modification]
370438004947	intermolecular recognition site; other site
370438004948	dimerization interface [polypeptide binding]; other site
370438004949	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
370438004950	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370438004951	phosphorylation site [posttranslational modification]
370438004952	cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200
370438004953	2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294
370438004954	aspartate kinase; Reviewed; Region: PRK06635
370438004955	AAK_AK-DapG-like: Amino Acid Kinase Superfamily (AAK), AK-DapG-like; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the diaminopimelate-sensitive aspartokinase isoenzyme AKI (DapG), a monofunctional enzymes found in Bacilli; Region: AAK_AK-DapG-like; cd04246
370438004956	putative catalytic residues [active]
370438004957	putative nucleotide binding site [chemical binding]; other site
370438004958	putative aspartate binding site [chemical binding]; other site
370438004959	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
370438004960	putative allosteric regulatory site; other site
370438004961	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
370438004962	putative allosteric regulatory residue; other site
370438004963	homoserine kinase; Provisional; Region: PRK01212
370438004964	homoserine dehydrogenase; Provisional; Region: PRK06349
370438004965	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
370438004966	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
370438004967	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
370438004968	hypothetical protein; Provisional; Region: PRK04435
370438004969	C-terminal ACT domain of a small (; 147 a.a.) putative phenylalanine biosynthetic pathway protein described in Bacillus subtilis (BS) PheB (PheB-BS) and related domains; Region: ACT_PheB-BS; cd04888
370438004970	Stage IV sporulation protein A (spore_IV_A); Region: Spore_IV_A; pfam09547
370438004971	stage IV sporulation protein A; Region: spore_IV_A; TIGR02836
370438004972	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
370438004973	catalytic residues [active]
370438004974	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
370438004975	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
370438004976	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
370438004977	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410
370438004978	GTP-binding protein Der; Reviewed; Region: PRK00093
370438004979	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
370438004980	G1 box; other site
370438004981	GTP/Mg2+ binding site [chemical binding]; other site
370438004982	Switch I region; other site
370438004983	G2 box; other site
370438004984	Switch II region; other site
370438004985	G3 box; other site
370438004986	G4 box; other site
370438004987	G5 box; other site
370438004988	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
370438004989	G1 box; other site
370438004990	GTP/Mg2+ binding site [chemical binding]; other site
370438004991	Switch I region; other site
370438004992	G2 box; other site
370438004993	G3 box; other site
370438004994	Switch II region; other site
370438004995	G4 box; other site
370438004996	G5 box; other site
370438004997	putative FeS-containing Cyanobacterial-specific oxidoreductase; Region: cyano_FeS_chp; TIGR03279
370438004998	Protein of unknown function (DUF512); Region: DUF512; pfam04459
370438004999	Protein of unknown function (DUF3189); Region: DUF3189; pfam11385
370438005000	Protein of unknown function (DUF3189); Region: DUF3189; pfam11385
370438005001	YIEGIA protein; Region: YIEGIA; pfam14045
370438005002	Stage II sporulation protein P (SpoIIP); Region: SpoIIP; pfam07454
370438005003	stage II sporulation protein P; Region: spore_II_P; TIGR02867
370438005004	Protein of unknown function (DUF1614); Region: DUF1614; pfam07758
370438005005	cytidylate kinase; Provisional; Region: cmk; PRK00023
370438005006	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
370438005007	CMP-binding site; other site
370438005008	The sites determining sugar specificity; other site
370438005009	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
370438005010	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
370438005011	putative acyl-acceptor binding pocket; other site
370438005012	4-hydroxy-3-methylbut-2-enyl diphosphate reductase/S1 RNA-binding domain protein; Reviewed; Region: PRK00087
370438005013	LytB protein; Region: LYTB; cl00507
370438005014	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
370438005015	RNA binding site [nucleotide binding]; other site
370438005016	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
370438005017	RNA binding site [nucleotide binding]; other site
370438005018	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
370438005019	RNA binding site [nucleotide binding]; other site
370438005020	S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692
370438005021	RNA binding site [nucleotide binding]; other site
370438005022	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
370438005023	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
370438005024	hinge; other site
370438005025	active site
370438005026	prephenate dehydrogenase; Validated; Region: PRK08507
370438005027	prephenate dehydrogenase; Validated; Region: PRK06545
370438005028	C-terminal ACT domain of the monofunctional, NAD dependent, prephenate dehydrogenase (PDH); Region: ACT_PDH-BS; cd04909
370438005029	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
370438005030	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
370438005031	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
370438005032	substrate binding site [chemical binding]; other site
370438005033	active site
370438005034	catalytic residues [active]
370438005035	heterodimer interface [polypeptide binding]; other site
370438005036	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
370438005037	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
370438005038	pyridoxal 5'-phosphate binding site [chemical binding]; other site
370438005039	catalytic residue [active]
370438005040	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
370438005041	active site
370438005042	ribulose/triose binding site [chemical binding]; other site
370438005043	phosphate binding site [ion binding]; other site
370438005044	substrate (anthranilate) binding pocket [chemical binding]; other site
370438005045	product (indole) binding pocket [chemical binding]; other site
370438005046	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
370438005047	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
370438005048	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
370438005049	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
370438005050	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
370438005051	glutamine binding [chemical binding]; other site
370438005052	catalytic triad [active]
370438005053	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
370438005054	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
370438005055	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
370438005056	SNARE associated Golgi protein; Region: SNARE_assoc; cl00429
370438005057	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
370438005058	homotrimer interaction site [polypeptide binding]; other site
370438005059	active site
370438005060	Histidine Utilizing Protein, the hut operon positive regulatory protein; Region: HutP; cd11640
370438005061	hexamer interface [polypeptide binding]; other site
370438005062	RNA binding site [nucleotide binding]; other site
370438005063	Histidine-zinc binding site [chemical binding]; other site
370438005064	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
370438005065	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
370438005066	RNA binding surface [nucleotide binding]; other site
370438005067	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
370438005068	active site
370438005069	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
370438005070	putative active site [active]
370438005071	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
370438005072	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
370438005073	ATP binding site [chemical binding]; other site
370438005074	Uncharacterized membrane protein [Function unknown]; Region: SpmB; COG0700
370438005075	Uncharacterized membrane protein, required for spore maturation in B.subtilis. [General function prediction only]; Region: SpmA; COG2715
370438005076	Glucose inhibited division protein A; Region: GIDA; pfam01134
370438005077	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
370438005078	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
370438005079	SpoVR like protein; Region: SpoVR; pfam04293
370438005080	sporulation protein YhbH; Region: spore_yhbH; TIGR02877
370438005081	Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766
370438005082	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
370438005083	Sporulation and spore germination; Region: Germane; pfam10646
370438005084	Immunoglobulin-like domain of bacterial spore germination; Region: Gmad2; pfam10648
370438005085	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
370438005086	catalytic triad [active]
370438005087	UDP-N-acetylmuramyl tripeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurE; COG0769
370438005088	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
370438005089	Domain of unknown function (DUF1727); Region: DUF1727; pfam08353
370438005090	nicotinate phosphoribosyltransferase; Validated; Region: PRK09243
370438005091	Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570
370438005092	active site
370438005093	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431
370438005094	catalytic triad [active]
370438005095	conserved cis-peptide bond; other site
370438005096	Acylphosphatase; Region: Acylphosphatase; pfam00708
370438005097	cobalt transporter ATP-binding subunit; Provisional; Region: cbiO; PRK13647
370438005098	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
370438005099	Walker A/P-loop; other site
370438005100	ATP binding site [chemical binding]; other site
370438005101	Q-loop/lid; other site
370438005102	ABC transporter signature motif; other site
370438005103	Walker B; other site
370438005104	D-loop; other site
370438005105	H-loop/switch region; other site
370438005106	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
370438005107	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
370438005108	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
370438005109	Walker A/P-loop; other site
370438005110	ATP binding site [chemical binding]; other site
370438005111	Q-loop/lid; other site
370438005112	ABC transporter signature motif; other site
370438005113	Walker B; other site
370438005114	D-loop; other site
370438005115	H-loop/switch region; other site
370438005116	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
370438005117	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
370438005118	Walker A/P-loop; other site
370438005119	ATP binding site [chemical binding]; other site
370438005120	Q-loop/lid; other site
370438005121	ABC transporter signature motif; other site
370438005122	Walker B; other site
370438005123	D-loop; other site
370438005124	H-loop/switch region; other site
370438005125	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
370438005126	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
370438005127	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
370438005128	dimer interface [polypeptide binding]; other site
370438005129	PYR/PP interface [polypeptide binding]; other site
370438005130	TPP binding site [chemical binding]; other site
370438005131	substrate binding site [chemical binding]; other site
370438005132	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
370438005133	TPP-binding site; other site
370438005134	4Fe-4S binding domain; Region: Fer4; pfam00037
370438005135	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
370438005136	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
370438005137	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
370438005138	acyl-activating enzyme (AAE) consensus motif; other site
370438005139	AMP binding site [chemical binding]; other site
370438005140	active site
370438005141	CoA binding site [chemical binding]; other site
370438005142	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
370438005143	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
370438005144	putative active site [active]
370438005145	heme pocket [chemical binding]; other site
370438005146	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
370438005147	putative active site [active]
370438005148	heme pocket [chemical binding]; other site
370438005149	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
370438005150	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
370438005151	metal binding site [ion binding]; metal-binding site
370438005152	active site
370438005153	I-site; other site
370438005154	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
370438005155	Zn2+ binding site [ion binding]; other site
370438005156	Mg2+ binding site [ion binding]; other site
370438005157	helicase-exonuclease AddAB, AddA subunit, Firmicutes type; Region: addA_Gpos; TIGR02785
370438005158	Part of AAA domain; Region: AAA_19; pfam13245
370438005159	Family description; Region: UvrD_C_2; pfam13538
370438005160	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
370438005161	helicase-exonuclease AddAB, AddB subunit; Region: addB_Gpos; TIGR02773
370438005162	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
370438005163	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
370438005164	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
370438005165	active site
370438005166	metal binding site [ion binding]; metal-binding site
370438005167	DNA binding site [nucleotide binding]
370438005168	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
370438005169	active site 1 [active]
370438005170	active site 2 [active]
370438005171	Protein of unknown function (DUF441); Region: DUF441; cl01041
370438005172	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
370438005173	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370438005174	active site
370438005175	phosphorylation site [posttranslational modification]
370438005176	intermolecular recognition site; other site
370438005177	dimerization interface [polypeptide binding]; other site
370438005178	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
370438005179	DNA binding site [nucleotide binding]
370438005180	PBP superfamily domain; Region: PBP_like_2; cl17296
370438005181	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
370438005182	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
370438005183	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
370438005184	dimer interface [polypeptide binding]; other site
370438005185	conserved gate region; other site
370438005186	putative PBP binding loops; other site
370438005187	ABC-ATPase subunit interface; other site
370438005188	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
370438005189	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
370438005190	dimer interface [polypeptide binding]; other site
370438005191	conserved gate region; other site
370438005192	putative PBP binding loops; other site
370438005193	ABC-ATPase subunit interface; other site
370438005194	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
370438005195	PhoU domain; Region: PhoU; pfam01895
370438005196	PhoU domain; Region: PhoU; pfam01895
370438005197	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
370438005198	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
370438005199	Walker A/P-loop; other site
370438005200	ATP binding site [chemical binding]; other site
370438005201	Q-loop/lid; other site
370438005202	ABC transporter signature motif; other site
370438005203	Walker B; other site
370438005204	D-loop; other site
370438005205	H-loop/switch region; other site
370438005206	Anti-sigma factor N-terminus; Region: RsgI_N; pfam12791
370438005207	putative RNA polymerase sigma factor SigI; Reviewed; Region: PRK08311
370438005208	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
370438005209	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
370438005210	histidinol dehydrogenase; Region: hisD; TIGR00069
370438005211	NAD binding site [chemical binding]; other site
370438005212	dimerization interface [polypeptide binding]; other site
370438005213	product binding site; other site
370438005214	substrate binding site [chemical binding]; other site
370438005215	zinc binding site [ion binding]; other site
370438005216	catalytic residues [active]
370438005217	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
370438005218	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
370438005219	NAD(P) binding site [chemical binding]; other site
370438005220	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
370438005221	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
370438005222	Walker A/P-loop; other site
370438005223	ATP binding site [chemical binding]; other site
370438005224	Q-loop/lid; other site
370438005225	ABC transporter signature motif; other site
370438005226	Walker B; other site
370438005227	D-loop; other site
370438005228	H-loop/switch region; other site
370438005229	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
370438005230	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
370438005231	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
370438005232	TM-ABC transporter signature motif; other site
370438005233	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
370438005234	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
370438005235	ligand binding site [chemical binding]; other site
370438005236	Domain of unknown function (DUF1992); Region: DUF1992; pfam09350
370438005237	Ntn-hydrolase superfamily, L-Asparaginase type 2-like enzymes. This family includes Glycosylasparaginase, Taspase 1 and  L-Asparaginase type 2 enzymes. Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked...; Region: Ntn_Asparaginase_2_like; cd04512
370438005238	active site
370438005239	dimer interface [polypeptide binding]; other site
370438005240	catalytic nucleophile [active]
370438005241	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
370438005242	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
370438005243	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
370438005244	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438005245	Walker A motif; other site
370438005246	ATP binding site [chemical binding]; other site
370438005247	Walker B motif; other site
370438005248	arginine finger; other site
370438005249	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
370438005250	Helix-turn-helix domain; Region: HTH_19; pfam12844
370438005251	non-specific DNA binding site [nucleotide binding]; other site
370438005252	salt bridge; other site
370438005253	sequence-specific DNA binding site [nucleotide binding]; other site
370438005254	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
370438005255	Catalytic site [active]
370438005256	Protein involved in formate dehydrogenase formation; Region: FdhE; pfam04216
370438005257	formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562
370438005258	hydrogenase nickel incorporation protein; Provisional; Region: hypA; PRK03824
370438005259	Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155
370438005260	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
370438005261	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
370438005262	Walker A motif; other site
370438005263	Acylphosphatase; Region: Acylphosphatase; pfam00708
370438005264	Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068
370438005265	HypF finger; Region: zf-HYPF; pfam07503
370438005266	HypF finger; Region: zf-HYPF; pfam07503
370438005267	Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300
370438005268	HupF/HypC family; Region: HupF_HypC; pfam01455
370438005269	hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062
370438005270	HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis.  HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197
370438005271	dimerization interface [polypeptide binding]; other site
370438005272	hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124
370438005273	ATP binding site [chemical binding]; other site
370438005274	coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130
370438005275	Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062
370438005276	putative substrate-binding site; other site
370438005277	nickel binding site [ion binding]; other site
370438005278	Ni,Fe-hydrogenase I small subunit [Energy production and conversion]; Region: HyaA; COG1740
370438005279	NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058
370438005280	Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374
370438005281	Nickel-dependent hydrogenase; Region: NiFeSe_Hases; pfam00374
370438005282	formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582
370438005283	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
370438005284	Polysulphide reductase, NrfD; Region: NrfD; pfam03916
370438005285	4-Oxalocrotonate Tautomerase:  Catalyzes the isomerization of unsaturated ketones. The structure is a homohexamer that is arranged as a trimer of dimers. The hexamer contains six active sites, each formed by residues from three monomers, two from one...; Region: 4Oxalocrotonate_Tautomerase; cl00235
370438005286	active site 1 [active]
370438005287	dimer interface [polypeptide binding]; other site
370438005288	hexamer interface [polypeptide binding]; other site
370438005289	active site 2 [active]
370438005290	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
370438005291	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
370438005292	catalytic triad [active]
370438005293	hypothetical protein; Reviewed; Region: PRK12497
370438005294	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
370438005295	RNA/DNA hybrid binding site [nucleotide binding]; other site
370438005296	active site
370438005297	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
370438005298	Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902
370438005299	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
370438005300	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
370438005301	molybdopterin cofactor binding site; other site
370438005302	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
370438005303	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
370438005304	molybdopterin cofactor binding site; other site
370438005305	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
370438005306	Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901
370438005307	twin arginine translocase protein A; Provisional; Region: tatA; PRK14861
370438005308	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
370438005309	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
370438005310	GTP/Mg2+ binding site [chemical binding]; other site
370438005311	G4 box; other site
370438005312	G5 box; other site
370438005313	G1 box; other site
370438005314	Switch I region; other site
370438005315	G2 box; other site
370438005316	G3 box; other site
370438005317	Switch II region; other site
370438005318	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
370438005319	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
370438005320	Catalytic site [active]
370438005321	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
370438005322	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
370438005323	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
370438005324	RimM N-terminal domain; Region: RimM; pfam01782
370438005325	PRC-barrel domain; Region: PRC; pfam05239
370438005326	Protein of unknown function (DUF2869); Region: DUF2869; pfam11068
370438005327	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
370438005328	hypothetical protein; Provisional; Region: PRK00468
370438005329	G-X-X-G motif; other site
370438005330	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
370438005331	signal recognition particle protein; Provisional; Region: PRK10867
370438005332	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
370438005333	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
370438005334	P loop; other site
370438005335	GTP binding site [chemical binding]; other site
370438005336	Signal peptide binding domain; Region: SRP_SPB; pfam02978
370438005337	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
370438005338	DNA binding residues [nucleotide binding]
370438005339	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
370438005340	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
370438005341	inhibitor-cofactor binding pocket; inhibition site
370438005342	pyridoxal 5'-phosphate binding site [chemical binding]; other site
370438005343	catalytic residue [active]
370438005344	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
370438005345	dimerization interface [polypeptide binding]; other site
370438005346	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
370438005347	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
370438005348	metal binding site [ion binding]; metal-binding site
370438005349	active site
370438005350	I-site; other site
370438005351	N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038
370438005352	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
370438005353	active site
370438005354	putative substrate binding pocket [chemical binding]; other site
370438005355	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
370438005356	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
370438005357	homotetramer interface [polypeptide binding]; other site
370438005358	ligand binding site [chemical binding]; other site
370438005359	catalytic site [active]
370438005360	NAD binding site [chemical binding]; other site
370438005361	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182; cl00348
370438005362	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
370438005363	5'-methylthioadenosine phosphorylase; Validated; Region: PRK08666
370438005364	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
370438005365	dimerization interface [polypeptide binding]; other site
370438005366	putative DNA binding site [nucleotide binding]; other site
370438005367	putative Zn2+ binding site [ion binding]; other site
370438005368	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
370438005369	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
370438005370	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
370438005371	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
370438005372	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
370438005373	active site residue [active]
370438005374	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cl00436
370438005375	CPxP  motif; other site
370438005376	DsrE/DsrF/DrsH-like family; Region: DrsE_2; pfam13686
370438005377	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
370438005378	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
370438005379	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
370438005380	P loop; other site
370438005381	GTP binding site [chemical binding]; other site
370438005382	ribonuclease III; Reviewed; Region: rnc; PRK00102
370438005383	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
370438005384	dimerization interface [polypeptide binding]; other site
370438005385	active site
370438005386	metal binding site [ion binding]; metal-binding site
370438005387	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
370438005388	dsRNA binding site [nucleotide binding]; other site
370438005389	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
370438005390	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
370438005391	dimer interface [polypeptide binding]; other site
370438005392	active site
370438005393	acyl carrier protein; Provisional; Region: acpP; PRK00982
370438005394	Phosphopantetheine attachment site; Region: PP-binding; cl09936
370438005395	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
370438005396	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
370438005397	NAD(P) binding site [chemical binding]; other site
370438005398	homotetramer interface [polypeptide binding]; other site
370438005399	homodimer interface [polypeptide binding]; other site
370438005400	active site
370438005401	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
370438005402	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
370438005403	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
370438005404	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
370438005405	FMN binding site [chemical binding]; other site
370438005406	substrate binding site [chemical binding]; other site
370438005407	putative catalytic residue [active]
370438005408	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
370438005409	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
370438005410	dimer interface [polypeptide binding]; other site
370438005411	active site
370438005412	CoA binding pocket [chemical binding]; other site
370438005413	putative phosphate acyltransferase; Provisional; Region: PRK05331
370438005414	fatty acid biosynthesis transcriptional regulator; Provisional; Region: PRK04424
370438005415	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
370438005416	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
370438005417	sporulation integral membrane protein YlbJ; Region: spore_ylbJ; TIGR02871
370438005418	Nucleoside recognition; Region: Gate; pfam07670
370438005419	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
370438005420	CoA binding domain; Region: CoA_binding_2; pfam13380
370438005421	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
370438005422	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
370438005423	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
370438005424	BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857
370438005425	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
370438005426	DRTGG domain; Region: DRTGG; pfam07085
370438005427	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
370438005428	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
370438005429	active site
370438005430	(T/H)XGH motif; other site
370438005431	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
370438005432	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
370438005433	S-adenosylmethionine binding site [chemical binding]; other site
370438005434	germination protease; Provisional; Region: PRK12362
370438005435	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
370438005436	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
370438005437	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
370438005438	generic binding surface II; other site
370438005439	ssDNA binding site; other site
370438005440	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
370438005441	ATP binding site [chemical binding]; other site
370438005442	putative Mg++ binding site [ion binding]; other site
370438005443	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
370438005444	nucleotide binding region [chemical binding]; other site
370438005445	ATP-binding site [chemical binding]; other site
370438005446	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
370438005447	homopentamer interface [polypeptide binding]; other site
370438005448	active site
370438005449	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311
370438005450	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
370438005451	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
370438005452	dimerization interface [polypeptide binding]; other site
370438005453	active site
370438005454	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
370438005455	Lumazine binding domain; Region: Lum_binding; pfam00677
370438005456	Lumazine binding domain; Region: Lum_binding; pfam00677
370438005457	diaminohydroxyphosphoribosylaminopyrimidine deaminase; Region: PLN02807
370438005458	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
370438005459	catalytic motif [active]
370438005460	Zn binding site [ion binding]; other site
370438005461	RibD C-terminal domain; Region: RibD_C; cl17279
370438005462	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
370438005463	dimer interface [polypeptide binding]; other site
370438005464	putative CheW interface [polypeptide binding]; other site
370438005465	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
370438005466	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
370438005467	active site
370438005468	(T/H)XGH motif; other site
370438005469	Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271
370438005470	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
370438005471	putative substrate translocation pore; other site
370438005472	Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440
370438005473	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
370438005474	oxidoreductase; Provisional; Region: PRK10015
370438005475	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
370438005476	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
370438005477	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
370438005478	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
370438005479	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
370438005480	Ligand binding site [chemical binding]; other site
370438005481	Electron transfer flavoprotein domain; Region: ETF; pfam01012
370438005482	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
370438005483	Short chain acyl-CoA dehydrogenases and eukaryotic short/branched chain acyl-CoA dehydrogenases; Region: SCAD_SBCAD; cd01158
370438005484	FAD binding site [chemical binding]; other site
370438005485	homotetramer interface [polypeptide binding]; other site
370438005486	substrate binding pocket [chemical binding]; other site
370438005487	catalytic base [active]
370438005488	Aromatic ring hydroxylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2368
370438005489	4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241
370438005490	Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670
370438005491	Coenzyme A transferase; Region: CoA_trans; smart00882
370438005492	Coenzyme A transferase; Region: CoA_trans; cl17247
370438005493	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
370438005494	PAS domain; Region: PAS_9; pfam13426
370438005495	putative active site [active]
370438005496	heme pocket [chemical binding]; other site
370438005497	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
370438005498	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438005499	Walker A motif; other site
370438005500	ATP binding site [chemical binding]; other site
370438005501	Walker B motif; other site
370438005502	arginine finger; other site
370438005503	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
370438005504	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
370438005505	DNA-binding site [nucleotide binding]; DNA binding site
370438005506	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
370438005507	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
370438005508	bis(5'-nucleosyl)-tetraphosphatase PrpE; Provisional; Region: PRK13625
370438005509	active site
370438005510	metal binding site [ion binding]; metal-binding site
370438005511	Accessory gene regulator B; Region: AgrB; pfam04647
370438005512	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
370438005513	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
370438005514	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
370438005515	putative active site [active]
370438005516	heme pocket [chemical binding]; other site
370438005517	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
370438005518	dimer interface [polypeptide binding]; other site
370438005519	phosphorylation site [posttranslational modification]
370438005520	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
370438005521	ATP binding site [chemical binding]; other site
370438005522	Mg2+ binding site [ion binding]; other site
370438005523	G-X-G motif; other site
370438005524	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
370438005525	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
370438005526	substrate binding site [chemical binding]; other site
370438005527	hexamer interface [polypeptide binding]; other site
370438005528	metal binding site [ion binding]; metal-binding site
370438005529	GTPase RsgA; Reviewed; Region: PRK00098
370438005530	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
370438005531	RNA binding site [nucleotide binding]; other site
370438005532	homodimer interface [polypeptide binding]; other site
370438005533	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
370438005534	GTPase/Zn-binding domain interface [polypeptide binding]; other site
370438005535	GTP/Mg2+ binding site [chemical binding]; other site
370438005536	G4 box; other site
370438005537	G5 box; other site
370438005538	G1 box; other site
370438005539	Switch I region; other site
370438005540	G2 box; other site
370438005541	G3 box; other site
370438005542	Switch II region; other site
370438005543	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
370438005544	Catalytic domain of Protein Kinases; Region: PKc; cd00180
370438005545	active site
370438005546	ATP binding site [chemical binding]; other site
370438005547	substrate binding site [chemical binding]; other site
370438005548	activation loop (A-loop); other site
370438005549	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2815
370438005550	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
370438005551	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
370438005552	PASTA domain of bacterial serine/threonine kinase pknB-like proteins. PknB is a member of a group of related transmembrane sensor kinases present in many gram positive bacteria, which has been shown to regulate cell shape in Mycobacterium tubercolosis; Region: PASTA_pknB; cd06577
370438005553	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
370438005554	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
370438005555	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
370438005556	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
370438005557	Protein phosphatase 2C; Region: PP2C; pfam00481
370438005558	active site
370438005559	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
370438005560	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
370438005561	phosphopeptide binding site; other site
370438005562	Protein of unknown function (DUF2662); Region: DUF3662; pfam12401
370438005563	FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716
370438005564	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
370438005565	phosphopeptide binding site; other site
370438005566	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14454
370438005567	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370438005568	FeS/SAM binding site; other site
370438005569	16S rRNA methyltransferase B; Provisional; Region: PRK14902
370438005570	NusB family; Region: NusB; pfam01029
370438005571	putative RNA binding site [nucleotide binding]; other site
370438005572	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
370438005573	S-adenosylmethionine binding site [chemical binding]; other site
370438005574	Protein of unknown function DUF116; Region: DUF116; pfam01976
370438005575	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
370438005576	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
370438005577	putative active site [active]
370438005578	substrate binding site [chemical binding]; other site
370438005579	putative cosubstrate binding site; other site
370438005580	catalytic site [active]
370438005581	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
370438005582	substrate binding site [chemical binding]; other site
370438005583	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
370438005584	active site
370438005585	catalytic residues [active]
370438005586	metal binding site [ion binding]; metal-binding site
370438005587	primosome assembly protein PriA; Validated; Region: PRK05580
370438005588	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
370438005589	ATP binding site [chemical binding]; other site
370438005590	putative Mg++ binding site [ion binding]; other site
370438005591	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
370438005592	ATP-binding site [chemical binding]; other site
370438005593	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
370438005594	Flavoprotein; Region: Flavoprotein; pfam02441
370438005595	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
370438005596	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
370438005597	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
370438005598	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
370438005599	catalytic site [active]
370438005600	G-X2-G-X-G-K; other site
370438005601	hypothetical protein; Provisional; Region: PRK04323
370438005602	hypothetical protein; Provisional; Region: PRK11820
370438005603	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
370438005604	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
370438005605	aspartate aminotransferase; Provisional; Region: PRK05764
370438005606	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
370438005607	pyridoxal 5'-phosphate binding site [chemical binding]; other site
370438005608	homodimer interface [polypeptide binding]; other site
370438005609	catalytic residue [active]
370438005610	LL-diaminopimelate aminotransferase; Provisional; Region: PRK09276
370438005611	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
370438005612	pyridoxal 5'-phosphate binding site [chemical binding]; other site
370438005613	homodimer interface [polypeptide binding]; other site
370438005614	catalytic residue [active]
370438005615	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
370438005616	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
370438005617	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
370438005618	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
370438005619	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
370438005620	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
370438005621	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
370438005622	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
370438005623	motif II; other site
370438005624	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
370438005625	Fibronectin-binding protein A N-terminus (FbpA); Region: FbpA; pfam05833
370438005626	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
370438005627	Domain of unknown function (DUF814); Region: DUF814; pfam05670
370438005628	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
370438005629	active site
370438005630	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
370438005631	active site
370438005632	dimer interface [polypeptide binding]; other site
370438005633	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
370438005634	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
370438005635	heterodimer interface [polypeptide binding]; other site
370438005636	active site
370438005637	FMN binding site [chemical binding]; other site
370438005638	homodimer interface [polypeptide binding]; other site
370438005639	substrate binding site [chemical binding]; other site
370438005640	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
370438005641	FAD binding pocket [chemical binding]; other site
370438005642	FAD binding motif [chemical binding]; other site
370438005643	phosphate binding motif [ion binding]; other site
370438005644	beta-alpha-beta structure motif; other site
370438005645	NAD binding pocket [chemical binding]; other site
370438005646	Iron coordination center [ion binding]; other site
370438005647	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
370438005648	IMP binding site; other site
370438005649	dimer interface [polypeptide binding]; other site
370438005650	interdomain contacts; other site
370438005651	partial ornithine binding site; other site
370438005652	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
370438005653	Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458
370438005654	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
370438005655	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
370438005656	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; smart01096
370438005657	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
370438005658	Carbamoylphosphate synthase large subunit (split gene in MJ) [Amino acid transport and metabolism / Nucleotide transport and metabolism]; Region: CarB; COG0458
370438005659	ATP-grasp domain; Region: ATP-grasp_4; cl17255
370438005660	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
370438005661	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
370438005662	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
370438005663	catalytic site [active]
370438005664	subunit interface [polypeptide binding]; other site
370438005665	dihydroorotase; Validated; Region: pyrC; PRK09357
370438005666	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
370438005667	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
370438005668	active site
370438005669	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
370438005670	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
370438005671	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
370438005672	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
370438005673	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
370438005674	active site
370438005675	Protein of unknown function (DUF342); Region: DUF342; pfam03961
370438005676	Protein of unknown function (DUF2619); Region: DUF2619; pfam10942
370438005677	(2R)-phospho-3-sulfolactate synthase (ComA); Region: ComA; pfam02679
370438005678	Protein of unknown function (DUF441); Region: DUF441; pfam04284
370438005679	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
370438005680	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
370438005681	RNA binding surface [nucleotide binding]; other site
370438005682	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
370438005683	active site
370438005684	lipoprotein signal peptidase; Provisional; Region: PRK14793
370438005685	lipoprotein signal peptidase; Provisional; Region: PRK14787
370438005686	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
370438005687	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
370438005688	active site
370438005689	HIGH motif; other site
370438005690	nucleotide binding site [chemical binding]; other site
370438005691	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
370438005692	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
370438005693	active site
370438005694	KMSKS motif; other site
370438005695	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
370438005696	tRNA binding surface [nucleotide binding]; other site
370438005697	anticodon binding site; other site
370438005698	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
370438005699	Uncharacterized ACR, YggU family COG1872; Region: DUF167; pfam02594
370438005700	PAC2 family; Region: PAC2; cl00847
370438005701	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
370438005702	putative active site [active]
370438005703	putative CoA binding site [chemical binding]; other site
370438005704	nudix motif; other site
370438005705	metal binding site [ion binding]; metal-binding site
370438005706	DivIVA protein; Region: DivIVA; pfam05103
370438005707	DivIVA domain; Region: DivI1A_domain; TIGR03544
370438005708	V-type ATP synthase subunit E; Provisional; Region: PRK01558
370438005709	YGGT family; Region: YGGT; pfam02325
370438005710	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
370438005711	pyrroline-5-carboxylate reductase; Region: PLN02688
370438005712	Protein of unknown function (DUF552); Region: DUF552; pfam04472
370438005713	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
370438005714	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
370438005715	catalytic residue [active]
370438005716	HlyD family secretion protein; Region: HlyD_2; pfam12700
370438005717	putative membrane fusion protein; Region: TIGR02828
370438005718	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
370438005719	dimerization interface [polypeptide binding]; other site
370438005720	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
370438005721	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
370438005722	putative active site [active]
370438005723	heme pocket [chemical binding]; other site
370438005724	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
370438005725	dimer interface [polypeptide binding]; other site
370438005726	phosphorylation site [posttranslational modification]
370438005727	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
370438005728	ATP binding site [chemical binding]; other site
370438005729	Mg2+ binding site [ion binding]; other site
370438005730	G-X-G motif; other site
370438005731	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
370438005732	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370438005733	active site
370438005734	phosphorylation site [posttranslational modification]
370438005735	intermolecular recognition site; other site
370438005736	dimerization interface [polypeptide binding]; other site
370438005737	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
370438005738	DNA binding site [nucleotide binding]
370438005739	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
370438005740	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
370438005741	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
370438005742	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
370438005743	Beta-Casp domain; Region: Beta-Casp; smart01027
370438005744	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
370438005745	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
370438005746	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
370438005747	Intracellular proteinase inhibitor; Region: BsuPI; pfam12690
370438005748	germination protein, Ger(x)C family; Region: spore_ger_x_C; TIGR02887
370438005749	Spore germination B3/ GerAC like, C-terminal; Region: Spore_GerAC; pfam05504
370438005750	Spore germination protein; Region: Spore_permease; cl17796
370438005751	Bacillus/Clostridium GerA spore germination protein; Region: GerA; pfam03323
370438005752	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
370438005753	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370438005754	FeS/SAM binding site; other site
370438005755	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK07111
370438005756	ATP cone domain; Region: ATP-cone; pfam03477
370438005757	Class III ribonucleotide reductase; Region: RNR_III; cd01675
370438005758	effector binding site; other site
370438005759	active site
370438005760	Zn binding site [ion binding]; other site
370438005761	glycine loop; other site
370438005762	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
370438005763	ATP cone domain; Region: ATP-cone; pfam03477
370438005764	sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888
370438005765	sporulation sigma factor SigG; Reviewed; Region: PRK08215
370438005766	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
370438005767	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
370438005768	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
370438005769	DNA binding residues [nucleotide binding]
370438005770	sporulation sigma factor SigE; Reviewed; Region: PRK08301
370438005771	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
370438005772	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
370438005773	DNA binding residues [nucleotide binding]
370438005774	Sporulation factor SpoIIGA; Region: Peptidase_U4; pfam03419
370438005775	sigma-E processing peptidase SpoIIGA; Region: spore_II_GA; TIGR02854
370438005776	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
370438005777	Thiamine monophosphate kinase [Coenzyme metabolism]; Region: ThiL; COG0611
370438005778	dimerization interface [polypeptide binding]; other site
370438005779	putative ATP binding site [chemical binding]; other site
370438005780	cell division protein FtsZ; Validated; Region: PRK09330
370438005781	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
370438005782	nucleotide binding site [chemical binding]; other site
370438005783	SulA interaction site; other site
370438005784	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
370438005785	Cell division protein FtsA; Region: FtsA; smart00842
370438005786	Cell division protein FtsA; Region: FtsA; pfam14450
370438005787	Protein of unknown function (DUF1290); Region: DUF1290; pfam06947
370438005788	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
370438005789	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
370438005790	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3879
370438005791	Bacterial protein of unknown function (DUF881); Region: DUF881; pfam05949
370438005792	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
370438005793	Cell division protein FtsQ; Region: FtsQ; pfam03799
370438005794	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
370438005795	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
370438005796	hinge; other site
370438005797	active site
370438005798	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
370438005799	FAD binding domain; Region: FAD_binding_4; pfam01565
370438005800	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
370438005801	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
370438005802	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
370438005803	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
370438005804	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
370438005805	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
370438005806	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
370438005807	active site
370438005808	homodimer interface [polypeptide binding]; other site
370438005809	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
370438005810	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK14106
370438005811	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
370438005812	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
370438005813	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
370438005814	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
370438005815	Mg++ binding site [ion binding]; other site
370438005816	putative catalytic motif [active]
370438005817	putative substrate binding site [chemical binding]; other site
370438005818	UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770
370438005819	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
370438005820	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
370438005821	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
370438005822	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
370438005823	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
370438005824	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
370438005825	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
370438005826	stage V sporulation protein D; Region: spoVD_pbp; TIGR02214
370438005827	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
370438005828	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
370438005829	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
370438005830	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
370438005831	Cell division protein FtsL; Region: FtsL; cl11433
370438005832	MraW methylase family; Region: Methyltransf_5; pfam01795
370438005833	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
370438005834	cell division protein MraZ; Reviewed; Region: PRK00326
370438005835	MraZ protein; Region: MraZ; pfam02381
370438005836	MraZ protein; Region: MraZ; pfam02381
370438005837	histidinol-phosphatase; Provisional; Region: PRK07328
370438005838	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase of Hisj like; Region: PHP_HisPPase_Hisj_like; cd12110
370438005839	active site
370438005840	dimer interface [polypeptide binding]; other site
370438005841	CIMS - Cobalamine-independent methonine synthase, or MetE. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme catalyses the last step in...; Region: CIMS_like; cd03310
370438005842	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
370438005843	metal binding site 2 [ion binding]; metal-binding site
370438005844	putative DNA binding helix; other site
370438005845	metal binding site 1 [ion binding]; metal-binding site
370438005846	dimer interface [polypeptide binding]; other site
370438005847	structural Zn2+ binding site [ion binding]; other site
370438005848	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
370438005849	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
370438005850	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
370438005851	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
370438005852	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
370438005853	G1 box; other site
370438005854	GTP/Mg2+ binding site [chemical binding]; other site
370438005855	Switch I region; other site
370438005856	G2 box; other site
370438005857	G3 box; other site
370438005858	Switch II region; other site
370438005859	G4 box; other site
370438005860	G5 box; other site
370438005861	Nucleoside recognition; Region: Gate; pfam07670
370438005862	Nucleoside recognition; Region: Gate; pfam07670
370438005863	This entry represents the core domain of the ferrous iron (Fe2+) transport protein FeoA found in bacteria; Region: FeoA; smart00899
370438005864	Major Facilitator Superfamily; Region: MFS_1; pfam07690
370438005865	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
370438005866	Major Facilitator Superfamily; Region: MFS_1; pfam07690
370438005867	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
370438005868	Catalytic NodB homology domain of uncharacterized bacterial polysaccharide deacetylases; Region: CE4_NodB_like_3; cd10959
370438005869	NodB motif; other site
370438005870	putative active site [active]
370438005871	putative catalytic site [active]
370438005872	putative Zn binding site [ion binding]; other site
370438005873	FAD binding domain; Region: FAD_binding_4; pfam01565
370438005874	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
370438005875	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
370438005876	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
370438005877	Cysteine-rich domain; Region: CCG; pfam02754
370438005878	Cysteine-rich domain; Region: CCG; pfam02754
370438005879	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
370438005880	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
370438005881	protein binding site [polypeptide binding]; other site
370438005882	AAA domain; Region: AAA_32; pfam13654
370438005883	AAA ATPase domain; Region: AAA_16; pfam13191
370438005884	Walker A motif; other site
370438005885	ATP binding site [chemical binding]; other site
370438005886	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
370438005887	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
370438005888	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
370438005889	TM-ABC transporter signature motif; other site
370438005890	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
370438005891	active site
370438005892	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187
370438005893	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
370438005894	acyl-activating enzyme (AAE) consensus motif; other site
370438005895	AMP binding site [chemical binding]; other site
370438005896	active site
370438005897	CoA binding site [chemical binding]; other site
370438005898	HTH-like domain; Region: HTH_21; pfam13276
370438005899	Integrase core domain; Region: rve; pfam00665
370438005900	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
370438005901	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
370438005902	DNA binding residues [nucleotide binding]
370438005903	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
370438005904	Integrase core domain; Region: rve; pfam00665
370438005905	Integrase core domain; Region: rve_3; cl15866
370438005906	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
370438005907	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
370438005908	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438005909	Walker A motif; other site
370438005910	ATP binding site [chemical binding]; other site
370438005911	Walker B motif; other site
370438005912	arginine finger; other site
370438005913	HTH-like domain; Region: HTH_21; pfam13276
370438005914	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
370438005915	Transposase; Region: HTH_Tnp_1; pfam01527
370438005916	Transposase domain (DUF772); Region: DUF772; pfam05598
370438005917	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
370438005918	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
370438005919	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
370438005920	Integrase core domain; Region: rve; pfam00665
370438005921	Integrase core domain; Region: rve_3; cl15866
370438005922	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
370438005923	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
370438005924	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438005925	Walker A motif; other site
370438005926	ATP binding site [chemical binding]; other site
370438005927	Walker B motif; other site
370438005928	arginine finger; other site
370438005929	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
370438005930	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
370438005931	active site
370438005932	DNA binding site [nucleotide binding]
370438005933	Int/Topo IB signature motif; other site
370438005934	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
370438005935	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
370438005936	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
370438005937	active site
370438005938	DNA binding site [nucleotide binding]
370438005939	Int/Topo IB signature motif; other site
370438005940	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
370438005941	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722
370438005942	Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930
370438005943	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
370438005944	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
370438005945	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
370438005946	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
370438005947	Family of unknown function (DUF694); Region: DUF694; pfam05107
370438005948	Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843
370438005949	CRISPR associated protein Cas6; Region: Cas_Cas6; pfam01881
370438005950	CRISPR-associated endoribonuclease Cas6; Region: cas_cas6; TIGR01877
370438005951	CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cl17214
370438005952	CRISPR/Cas system-associated protein Cmr5; Region: Cmr5_III-B; cd09749
370438005953	CRISPR/Cas system-associated RAMP superfamily protein Cmr4; Region: Cmr4_III-B; cd09682
370438005954	CRISPR/Cas system-associated RAMP superfamily protein Cmr1; Region: Cmr1_III-B; cl17436
370438005955	CRISPR-associated protein (Cas_Cmr3); Region: Cas_Cmr3; pfam09700
370438005956	CRISPR/Cas system-associated RAMP superfamily protein Cmr3; Region: Cmr3_III-B; cd09748
370438005957	CRISPR/Cas system-associated protein Cas10; Region: Cas10_III; cd09679
370438005958	CRISPR-associated protein Cas10/Cmr2, subtype III-B; Region: cas_TM1794_Cmr2; TIGR02577
370438005959	CRISPR/Cas system-associated protein Csx15; Region: Csx15_I-U; cd09766
370438005960	Domain of unknown function (DUF1887); Region: DUF1887; pfam09002
370438005961	CRISPR/Cas system-associated protein Csx1; Region: Csx1_III-U; cd09741
370438005962	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
370438005963	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
370438005964	DNA binding residues [nucleotide binding]
370438005965	Predicted transcriptional regulator contains Xre-like HTH domain [Function unknown]; Region: COG1426
370438005966	Helix-turn-helix domain; Region: HTH_25; pfam13413
370438005967	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
370438005968	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
370438005969	Transglycosylase; Region: Transgly; pfam00912
370438005970	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
370438005971	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
370438005972	DNA adenine methylase (dam); Region: dam; TIGR00571
370438005973	Protein of unknown function (DUF2680); Region: DUF2680; pfam10925
370438005974	Carbohydrate binding domain; Region: CBM_25; smart01066
370438005975	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
370438005976	MutS domain III; Region: MutS_III; pfam05192
370438005977	ATP-binding cassette domain of MutS2; Region: ABC_MutS2; cd03280
370438005978	Walker A/P-loop; other site
370438005979	ATP binding site [chemical binding]; other site
370438005980	Q-loop/lid; other site
370438005981	ABC transporter signature motif; other site
370438005982	Walker B; other site
370438005983	D-loop; other site
370438005984	H-loop/switch region; other site
370438005985	Smr domain; Region: Smr; pfam01713
370438005986	manganese transport transcriptional regulator; Provisional; Region: PRK03902
370438005987	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
370438005988	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
370438005989	Nucleoside recognition; Region: Gate; pfam07670
370438005990	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
370438005991	Nucleoside recognition; Region: Gate; pfam07670
370438005992	Ferrous iron transport protein B; Region: FeoB_N; pfam02421
370438005993	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
370438005994	G1 box; other site
370438005995	GTP/Mg2+ binding site [chemical binding]; other site
370438005996	Switch I region; other site
370438005997	G2 box; other site
370438005998	G3 box; other site
370438005999	Switch II region; other site
370438006000	G4 box; other site
370438006001	G5 box; other site
370438006002	FeoA domain; Region: FeoA; pfam04023
370438006003	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
370438006004	Peptidase family U32; Region: Peptidase_U32; pfam01136
370438006005	Collagenase; Region: DUF3656; pfam12392
370438006006	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
370438006007	Peptidase family U32; Region: Peptidase_U32; pfam01136
370438006008	Uncharacterized conserved protein [Function unknown]; Region: COG0327
370438006009	NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784
370438006010	Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540
370438006011	active site
370438006012	DNA binding site [nucleotide binding]
370438006013	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
370438006014	hypothetical protein; Provisional; Region: PRK08609
370438006015	active site
370438006016	primer binding site [nucleotide binding]; other site
370438006017	NTP  binding site [chemical binding]; other site
370438006018	metal binding triad [ion binding]; metal-binding site
370438006019	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
370438006020	active site
370438006021	Cell division protein ZapA; Region: ZapA; cl01146
370438006022	Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; Region: PheT; COG0072
370438006023	B3/4 domain; Region: B3_4; pfam03483
370438006024	tRNA synthetase B5 domain; Region: B5; smart00874
370438006025	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
370438006026	dimer interface [polypeptide binding]; other site
370438006027	motif 1; other site
370438006028	motif 3; other site
370438006029	motif 2; other site
370438006030	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
370438006031	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
370438006032	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
370438006033	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
370438006034	dimer interface [polypeptide binding]; other site
370438006035	motif 1; other site
370438006036	active site
370438006037	motif 2; other site
370438006038	motif 3; other site
370438006039	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
370438006040	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
370438006041	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
370438006042	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
370438006043	TrkA-N domain; Region: TrkA_N; pfam02254
370438006044	TrkA-C domain; Region: TrkA_C; pfam02080
370438006045	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
370438006046	23S rRNA binding site [nucleotide binding]; other site
370438006047	L21 binding site [polypeptide binding]; other site
370438006048	L13 binding site [polypeptide binding]; other site
370438006049	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
370438006050	translation initiation factor IF-3; Region: infC; TIGR00168
370438006051	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
370438006052	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
370438006053	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
370438006054	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
370438006055	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
370438006056	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
370438006057	active site
370438006058	dimer interface [polypeptide binding]; other site
370438006059	motif 1; other site
370438006060	motif 2; other site
370438006061	motif 3; other site
370438006062	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
370438006063	anticodon binding site; other site
370438006064	YtxC-like family; Region: YtxC; pfam08812
370438006065	PDGLE domain; Region: PDGLE; pfam13190
370438006066	ABC-type Co2+ transport system, permease component [Inorganic ion transport and metabolism]; Region: CbiM; cl00397
370438006067	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
370438006068	Peptidase family M48; Region: Peptidase_M48; cl12018
370438006069	Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530
370438006070	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
370438006071	DNA polymerase II large subunit; Provisional; Region: PRK14714
370438006072	Coronavirus S2 glycoprotein; Region: Corona_S2; pfam01601
370438006073	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
370438006074	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
370438006075	non-specific DNA binding site [nucleotide binding]; other site
370438006076	salt bridge; other site
370438006077	sequence-specific DNA binding site [nucleotide binding]; other site
370438006078	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
370438006079	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
370438006080	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
370438006081	Sporulation lipoprotein YhcN/YlaJ (Spore_YhcN_YlaJ); Region: Spore_YhcN_YlaJ; pfam09580
370438006082	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996
370438006083	AMIN domain; Region: AMIN; pfam11741
370438006084	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
370438006085	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
370438006086	active site
370438006087	metal binding site [ion binding]; metal-binding site
370438006088	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
370438006089	active site
370438006090	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
370438006091	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
370438006092	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
370438006093	C-terminal peptidase (prc); Region: prc; TIGR00225
370438006094	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
370438006095	protein binding site [polypeptide binding]; other site
370438006096	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
370438006097	Catalytic dyad [active]
370438006098	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
370438006099	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
370438006100	DNA polymerase I; Provisional; Region: PRK05755
370438006101	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
370438006102	active site
370438006103	metal binding site 1 [ion binding]; metal-binding site
370438006104	putative 5' ssDNA interaction site; other site
370438006105	metal binding site 3; metal-binding site
370438006106	metal binding site 2 [ion binding]; metal-binding site
370438006107	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
370438006108	putative DNA binding site [nucleotide binding]; other site
370438006109	putative metal binding site [ion binding]; other site
370438006110	inactive DEDDy 3'-5' exonuclease domain of Bacillus stearothermophilus DNA polymerase I and similar family-A DNA polymerases; Region: DNA_polA_I_Bacillus_like_exo; cd06140
370438006111	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
370438006112	active site
370438006113	DNA binding site [nucleotide binding]
370438006114	catalytic site [active]
370438006115	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
370438006116	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
370438006117	DNA binding site [nucleotide binding]
370438006118	catalytic residue [active]
370438006119	H2TH interface [polypeptide binding]; other site
370438006120	putative catalytic residues [active]
370438006121	turnover-facilitating residue; other site
370438006122	intercalation triad [nucleotide binding]; other site
370438006123	8OG recognition residue [nucleotide binding]; other site
370438006124	putative reading head residues; other site
370438006125	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
370438006126	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
370438006127	putative sporulation protein YtaF; Region: spore_YtaF; TIGR02840
370438006128	Domain of unknown function DUF; Region: DUF204; pfam02659
370438006129	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
370438006130	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
370438006131	CoA-binding site [chemical binding]; other site
370438006132	ATP-binding [chemical binding]; other site
370438006133	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
370438006134	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
370438006135	N-acetyl-D-glucosamine binding site [chemical binding]; other site
370438006136	catalytic residue [active]
370438006137	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
370438006138	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
370438006139	Small, acid-soluble spore proteins, alpha/beta type; Region: SASP; pfam00269
370438006140	phosphatidylserine decarboxylase; Provisional; Region: PRK05305
370438006141	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
370438006142	CDP-diacylglycerol--serine O-phosphatidyltransferase; Region: pssA; TIGR00473
370438006143	Domain of unknown function (DUF4258); Region: DUF4258; pfam14076
370438006144	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
370438006145	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
370438006146	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
370438006147	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465
370438006148	CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cl01465
370438006149	CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cl12004
370438006150	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09651
370438006151	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
370438006152	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
370438006153	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
370438006154	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
370438006155	Predicted transcriptional regulator [Transcription]; Region: COG2378
370438006156	HTH domain; Region: HTH_11; pfam08279
370438006157	WYL domain; Region: WYL; pfam13280
370438006158	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
370438006159	generic binding surface II; other site
370438006160	generic binding surface I; other site
370438006161	Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481
370438006162	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
370438006163	Zn2+ binding site [ion binding]; other site
370438006164	Mg2+ binding site [ion binding]; other site
370438006165	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
370438006166	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
370438006167	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
370438006168	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
370438006169	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
370438006170	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
370438006171	active site
370438006172	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
370438006173	Ligand binding site [chemical binding]; other site
370438006174	Electron transfer flavoprotein domain; Region: ETF; pfam01012
370438006175	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
370438006176	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
370438006177	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
370438006178	PAS domain S-box; Region: sensory_box; TIGR00229
370438006179	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
370438006180	putative active site [active]
370438006181	heme pocket [chemical binding]; other site
370438006182	PAS domain S-box; Region: sensory_box; TIGR00229
370438006183	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
370438006184	putative active site [active]
370438006185	heme pocket [chemical binding]; other site
370438006186	PAS domain S-box; Region: sensory_box; TIGR00229
370438006187	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
370438006188	putative active site [active]
370438006189	heme pocket [chemical binding]; other site
370438006190	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
370438006191	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
370438006192	metal binding site [ion binding]; metal-binding site
370438006193	active site
370438006194	I-site; other site
370438006195	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
370438006196	Zn2+ binding site [ion binding]; other site
370438006197	Mg2+ binding site [ion binding]; other site
370438006198	Arginine/lysine/ornithine decarboxylases [Amino acid transport and metabolism]; Region: LdcC; COG1982
370438006199	Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615
370438006200	homodimer interface [polypeptide binding]; other site
370438006201	pyridoxal 5'-phosphate binding site [chemical binding]; other site
370438006202	catalytic residue [active]
370438006203	Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711
370438006204	F420-0:Gamma-glutamyl ligase; Region: F420_ligase; pfam01996
370438006205	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
370438006206	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
370438006207	active site
370438006208	metal binding site [ion binding]; metal-binding site
370438006209	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
370438006210	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
370438006211	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
370438006212	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
370438006213	catalytic loop [active]
370438006214	iron binding site [ion binding]; other site
370438006215	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
370438006216	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
370438006217	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
370438006218	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
370438006219	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
370438006220	dimer interface [polypeptide binding]; other site
370438006221	[2Fe-2S] cluster binding site [ion binding]; other site
370438006222	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
370438006223	SLBB domain; Region: SLBB; pfam10531
370438006224	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
370438006225	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
370438006226	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
370438006227	putative dimer interface [polypeptide binding]; other site
370438006228	[2Fe-2S] cluster binding site [ion binding]; other site
370438006229	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
370438006230	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
370438006231	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
370438006232	DEAD-like helicases superfamily; Region: DEXDc; smart00487
370438006233	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
370438006234	ATP binding site [chemical binding]; other site
370438006235	putative Mg++ binding site [ion binding]; other site
370438006236	helicase superfamily c-terminal domain; Region: HELICc; smart00490
370438006237	nucleotide binding region [chemical binding]; other site
370438006238	ATP-binding site [chemical binding]; other site
370438006239	DSHCT (NUC185) domain; Region: DSHCT; pfam08148
370438006240	SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cd00296
370438006241	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
370438006242	G1 box; other site
370438006243	GTP/Mg2+ binding site [chemical binding]; other site
370438006244	G2 box; other site
370438006245	Switch I region; other site
370438006246	G3 box; other site
370438006247	Switch II region; other site
370438006248	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
370438006249	G1 box; other site
370438006250	GTP/Mg2+ binding site [chemical binding]; other site
370438006251	G2 box; other site
370438006252	Switch I region; other site
370438006253	G3 box; other site
370438006254	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
370438006255	G3 box; other site
370438006256	Switch II region; other site
370438006257	GTP/Mg2+ binding site [chemical binding]; other site
370438006258	G4 box; other site
370438006259	G5 box; other site
370438006260	Coat F domain; Region: Coat_F; pfam07875
370438006261	Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039
370438006262	Transposase domain (DUF772); Region: DUF772; pfam05598
370438006263	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
370438006264	putative CheW interface [polypeptide binding]; other site
370438006265	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
370438006266	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
370438006267	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
370438006268	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438006269	Walker A motif; other site
370438006270	ATP binding site [chemical binding]; other site
370438006271	Walker B motif; other site
370438006272	Uncharacterized conserved protein [Function unknown]; Region: COG1284
370438006273	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
370438006274	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
370438006275	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
370438006276	Uncharacterized membrane protein [Function unknown]; Region: SapB; COG1285
370438006277	MgtC family; Region: MgtC; pfam02308
370438006278	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
370438006279	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992
370438006280	active site
370438006281	Zn binding site [ion binding]; other site
370438006282	Serine dehydrogenase proteinase; Region: SDH_sah; pfam01972
370438006283	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
370438006284	active site
370438006285	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
370438006286	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
370438006287	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
370438006288	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
370438006289	trimer interface [polypeptide binding]; other site
370438006290	putative metal binding site [ion binding]; other site
370438006291	BON domain; Region: BON; pfam04972
370438006292	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
370438006293	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
370438006294	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
370438006295	dimer interface [polypeptide binding]; other site
370438006296	phosphorylation site [posttranslational modification]
370438006297	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
370438006298	ATP binding site [chemical binding]; other site
370438006299	Mg2+ binding site [ion binding]; other site
370438006300	G-X-G motif; other site
370438006301	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
370438006302	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370438006303	active site
370438006304	phosphorylation site [posttranslational modification]
370438006305	intermolecular recognition site; other site
370438006306	dimerization interface [polypeptide binding]; other site
370438006307	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
370438006308	DNA binding residues [nucleotide binding]
370438006309	dimerization interface [polypeptide binding]; other site
370438006310	Coenzyme A transferase; Region: CoA_trans; cl17247
370438006311	Coenzyme A transferase; Region: CoA_trans; smart00882
370438006312	Coenzyme A transferase; Region: CoA_trans; smart00882
370438006313	Coenzyme A transferase; Region: CoA_trans; cl17247
370438006314	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
370438006315	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
370438006316	Putative NodB-like catalytic domain of uncharacterized proteins found in bacteria; Region: CE4_COG5298; cd10923
370438006317	Uncharacterized protein conserved in bacteria (DUF2334); Region: DUF2334; pfam10096
370438006318	NodB motif; other site
370438006319	putative active site [active]
370438006320	putative catalytic site [active]
370438006321	putative Zn binding site [ion binding]; other site
370438006322	Family description; Region: VCBS; pfam13517
370438006323	Family description; Region: VCBS; pfam13517
370438006324	Family description; Region: VCBS; pfam13517
370438006325	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
370438006326	Predicted metal-binding protein (DUF2284); Region: DUF2284; pfam10050
370438006327	Putative redox-active protein (C_GCAxxG_C_C); Region: C_GCAxxG_C_C; pfam09719
370438006328	Protein of unknown function (DUF503); Region: DUF503; pfam04456
370438006329	pyrophosphatase PpaX; Provisional; Region: PRK13288
370438006330	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
370438006331	active site
370438006332	motif I; other site
370438006333	motif II; other site
370438006334	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
370438006335	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
370438006336	active site
370438006337	metal binding site [ion binding]; metal-binding site
370438006338	flagellar motor switch protein; Validated; Region: PRK08119
370438006339	CheC-like family; Region: CheC; pfam04509
370438006340	CheC-like family; Region: CheC; pfam04509
370438006341	Surface presentation of antigens (SPOA); Region: SpoA; cl00819
370438006342	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
370438006343	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
370438006344	Response regulator receiver domain; Region: Response_reg; pfam00072
370438006345	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370438006346	active site
370438006347	phosphorylation site [posttranslational modification]
370438006348	intermolecular recognition site; other site
370438006349	dimerization interface [polypeptide binding]; other site
370438006350	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
370438006351	CheC-like family; Region: CheC; pfam04509
370438006352	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
370438006353	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
370438006354	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
370438006355	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
370438006356	S-adenosylmethionine binding site [chemical binding]; other site
370438006357	CheD chemotactic sensory transduction; Region: CheD; cl00810
370438006358	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
370438006359	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
370438006360	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
370438006361	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
370438006362	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
370438006363	RNA polymerase sigma factor WhiG; Reviewed; Region: PRK06288
370438006364	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
370438006365	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
370438006366	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
370438006367	DNA binding residues [nucleotide binding]
370438006368	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
370438006369	Flagellar protein YcgR; Region: YcgR_2; pfam12945
370438006370	PilZ domain; Region: PilZ; pfam07238
370438006371	Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455
370438006372	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
370438006373	P-loop; other site
370438006374	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
370438006375	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
370438006376	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
370438006377	FHIPEP family; Region: FHIPEP; pfam00771
370438006378	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
370438006379	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
370438006380	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
370438006381	Bacterial export proteins, family 3; Region: Bac_export_3; cl00867
370438006382	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
370438006383	flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500
370438006384	Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886
370438006385	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07718
370438006386	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
370438006387	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12636
370438006388	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
370438006389	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
370438006390	Protein of unknown function (DUF3766); Region: DUF3766; cl11797
370438006391	flagellar basal body rod modification protein; Provisional; Region: flgD; PRK09618
370438006392	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
370438006393	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
370438006394	Flagellar FliJ protein; Region: FliJ; pfam02050
370438006395	flagellar protein export ATPase FliI; Region: FliI_clade2; TIGR03497
370438006396	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
370438006397	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
370438006398	Walker A motif/ATP binding site; other site
370438006399	Walker B motif; other site
370438006400	S-layer homology domain; Region: SLH; pfam00395
370438006401	ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192
370438006402	type III secretion apparatus protein, HrpE/YscL family; Region: HrpE_YscL_not; TIGR02499
370438006403	Flagellar assembly protein FliH; Region: FliH; pfam02108
370438006404	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
370438006405	MgtE intracellular N domain; Region: MgtE_N; cl15244
370438006406	FliG C-terminal domain; Region: FliG_C; pfam01706
370438006407	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
370438006408	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
370438006409	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
370438006410	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
370438006411	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
370438006412	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
370438006413	Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815
370438006414	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
370438006415	FlaG protein; Region: FlaG; pfam03646
370438006416	FlgN protein; Region: FlgN; pfam05130
370438006417	Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516
370438006418	flagellar capping protein; Validated; Region: fliD; PRK07737
370438006419	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
370438006420	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
370438006421	flagellar assembly protein FliW; Provisional; Region: PRK13285
370438006422	Global regulator protein family; Region: CsrA; pfam02599
370438006423	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
370438006424	active site
370438006425	NTP binding site [chemical binding]; other site
370438006426	metal binding triad [ion binding]; metal-binding site
370438006427	antibiotic binding site [chemical binding]; other site
370438006428	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424
370438006429	active site
370438006430	catalytic triad [active]
370438006431	dimer interface [polypeptide binding]; other site
370438006432	RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646
370438006433	putative active site [active]
370438006434	putative NTP binding site [chemical binding]; other site
370438006435	putative nucleic acid binding site [nucleotide binding]; other site
370438006436	flagellin; Validated; Region: PRK08026
370438006437	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
370438006438	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
370438006439	Restriction endonuclease; Region: Mrr_cat; pfam04471
370438006440	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
370438006441	Protein of unknown function DUF86; Region: DUF86; pfam01934
370438006442	Transposase IS200 like; Region: Y1_Tnp; pfam01797
370438006443	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701
370438006444	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
370438006445	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
370438006446	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07739
370438006447	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
370438006448	FlgN protein; Region: FlgN; pfam05130
370438006449	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
370438006450	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
370438006451	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370438006452	active site
370438006453	phosphorylation site [posttranslational modification]
370438006454	intermolecular recognition site; other site
370438006455	dimerization interface [polypeptide binding]; other site
370438006456	CheB methylesterase; Region: CheB_methylest; pfam01339
370438006457	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
370438006458	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
370438006459	putative binding surface; other site
370438006460	active site
370438006461	P2 response regulator binding domain; Region: P2; pfam07194
370438006462	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
370438006463	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
370438006464	ATP binding site [chemical binding]; other site
370438006465	Mg2+ binding site [ion binding]; other site
370438006466	G-X-G motif; other site
370438006467	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
370438006468	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
370438006469	putative CheA interaction surface; other site
370438006470	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
370438006471	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
370438006472	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
370438006473	ligand binding site [chemical binding]; other site
370438006474	flagellar motor protein MotA; Validated; Region: PRK08124
370438006475	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
370438006476	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
370438006477	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
370438006478	HflX GTPase family; Region: HflX; cd01878
370438006479	G1 box; other site
370438006480	GTP/Mg2+ binding site [chemical binding]; other site
370438006481	Switch I region; other site
370438006482	G2 box; other site
370438006483	G3 box; other site
370438006484	Switch II region; other site
370438006485	G4 box; other site
370438006486	G5 box; other site
370438006487	Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768
370438006488	4Fe-4S binding domain; Region: Fer4; pfam00037
370438006489	4Fe-4S binding domain; Region: Fer4_6; pfam12837
370438006490	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
370438006491	Clp amino terminal domain; Region: Clp_N; pfam02861
370438006492	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438006493	Walker A motif; other site
370438006494	ATP binding site [chemical binding]; other site
370438006495	Walker B motif; other site
370438006496	arginine finger; other site
370438006497	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438006498	Walker A motif; other site
370438006499	ATP binding site [chemical binding]; other site
370438006500	Walker B motif; other site
370438006501	arginine finger; other site
370438006502	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
370438006503	chaperone protein DnaJ; Provisional; Region: PRK14299
370438006504	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
370438006505	HSP70 interaction site [polypeptide binding]; other site
370438006506	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
370438006507	substrate binding site [polypeptide binding]; other site
370438006508	dimer interface [polypeptide binding]; other site
370438006509	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
370438006510	Group of bacterial proteins containing an alpha crystallin domain (ACD) similar to Lactobacillus plantarum (Lp) small heat shock proteins (sHsp) HSP 18.5, HSP 18.55 and HSP 19.3. sHsps are molecular chaperones that suppress protein aggregation and...; Region: ACD_LpsHSP_like; cd06471
370438006511	putative dimer interface [polypeptide binding]; other site
370438006512	FOG: CBS domain [General function prediction only]; Region: COG0517
370438006513	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc; cd04584
370438006514	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
370438006515	Coat F domain; Region: Coat_F; pfam07875
370438006516	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
370438006517	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
370438006518	metal binding site [ion binding]; metal-binding site
370438006519	active site
370438006520	I-site; other site
370438006521	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
370438006522	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
370438006523	Zn2+ binding site [ion binding]; other site
370438006524	Mg2+ binding site [ion binding]; other site
370438006525	acetyl-CoA synthetase; Provisional; Region: PRK00174
370438006526	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
370438006527	active site
370438006528	CoA binding site [chemical binding]; other site
370438006529	acyl-activating enzyme (AAE) consensus motif; other site
370438006530	AMP binding site [chemical binding]; other site
370438006531	acetate binding site [chemical binding]; other site
370438006532	NifU-like domain; Region: NifU; cl00484
370438006533	Putative zinc-finger; Region: zf-HC2; pfam13490
370438006534	Domain of unknown function (DUF4349); Region: DUF4349; pfam14257
370438006535	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
370438006536	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
370438006537	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
370438006538	DNA binding residues [nucleotide binding]
370438006539	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
370438006540	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N2; pfam13495
370438006541	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
370438006542	DNA binding site [nucleotide binding]
370438006543	Int/Topo IB signature motif; other site
370438006544	active site
370438006545	catalytic residues [active]
370438006546	Transposase domain (DUF772); Region: DUF772; pfam05598
370438006547	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
370438006548	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438006549	Walker A motif; other site
370438006550	ATP binding site [chemical binding]; other site
370438006551	Walker B motif; other site
370438006552	arginine finger; other site
370438006553	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
370438006554	Integrase core domain; Region: rve; pfam00665
370438006555	Integrase core domain; Region: rve_3; cl15866
370438006556	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
370438006557	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
370438006558	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
370438006559	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
370438006560	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
370438006561	DNA methylase; Region: N6_N4_Mtase; pfam01555
370438006562	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
370438006563	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
370438006564	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
370438006565	DNA binding residues [nucleotide binding]
370438006566	dephospho-CoA kinase; Region: TIGR00152
370438006567	deoxynucleoside monophosphate kinase; Provisional; Region: 1; PHA02575
370438006568	deoxynucleoside monophosphate kinase; Provisional; Region: 1; PHA02575
370438006569	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
370438006570	non-specific DNA binding site [nucleotide binding]; other site
370438006571	salt bridge; other site
370438006572	sequence-specific DNA binding site [nucleotide binding]; other site
370438006573	Thymidylate synthase complementing protein; Region: Thy1; pfam02511
370438006574	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
370438006575	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
370438006576	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
370438006577	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
370438006578	trimer interface [polypeptide binding]; other site
370438006579	active site
370438006580	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK08271
370438006581	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
370438006582	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
370438006583	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370438006584	FeS/SAM binding site; other site
370438006585	Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277
370438006586	putative active site [active]
370438006587	DNA polymerase I - 3'-5' exonuclease and polymerase domains [DNA replication, recombination, and repair]; Region: PolA; COG0749
370438006588	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
370438006589	active site
370438006590	catalytic site [active]
370438006591	substrate binding site [chemical binding]; other site
370438006592	Family A polymerase primarily fills DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A; cl02626
370438006593	active site
370438006594	DNA binding site [nucleotide binding]
370438006595	catalytic site [active]
370438006596	PhoH-like protein; Region: PhoH; cl17668
370438006597	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
370438006598	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
370438006599	non-specific DNA binding site [nucleotide binding]; other site
370438006600	salt bridge; other site
370438006601	sequence-specific DNA binding site [nucleotide binding]; other site
370438006602	CHC2 zinc finger; Region: zf-CHC2; cl17510
370438006603	Protein of unknown function (DUF3991); Region: DUF3991; pfam13154
370438006604	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
370438006605	active site
370438006606	metal binding site [ion binding]; metal-binding site
370438006607	interdomain interaction site; other site
370438006608	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
370438006609	Walker A motif; other site
370438006610	ATP binding site [chemical binding]; other site
370438006611	Walker B motif; other site
370438006612	hypothetical protein; Validated; Region: PRK08116
370438006613	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
370438006614	Helix-turn-helix domain; Region: HTH_36; pfam13730
370438006615	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
370438006616	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
370438006617	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
370438006618	amidase catalytic site [active]
370438006619	Zn binding residues [ion binding]; other site
370438006620	substrate binding site [chemical binding]; other site
370438006621	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
370438006622	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
370438006623	Protein of unknown function (DUF2762); Region: DUF2762; pfam10960
370438006624	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
370438006625	amidase catalytic site [active]
370438006626	Zn binding residues [ion binding]; other site
370438006627	substrate binding site [chemical binding]; other site
370438006628	Prophage endopeptidase tail; Region: Prophage_tail; cl12123
370438006629	Phage tail protein; Region: Sipho_tail; cl17486
370438006630	Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385
370438006631	Phage tail protein; Region: Sipho_tail; cl17486
370438006632	tape measure domain; Region: tape_meas_nterm; TIGR02675
370438006633	membrane protein P6; Region: PHA01399
370438006634	Conserved hypothetical phage protein (DUF2376); Region: DUF2376; cl09774
370438006635	Protein of unknown function (DUF3356); Region: DUF3356; pfam11836
370438006636	Phage major tail protein 2; Region: Phage_tail_2; pfam06199
370438006637	Minor capsid protein; Region: Minor_capsid_1; pfam10665
370438006638	Transposase domain (DUF772); Region: DUF772; pfam05598
370438006639	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
370438006640	major capsid protein; Region: PHA00665
370438006641	Phage minor capsid protein 2; Region: Phage_min_cap2; pfam06152
370438006642	Phage portal protein, SPP1 Gp6-like; Region: Phage_prot_Gp6; pfam05133
370438006643	phage portal protein, SPP1 family; Region: portal_SPP1; TIGR01538
370438006644	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5410
370438006645	Phage-related terminase [General function prediction only]; Region: COG5362; cl02216
370438006646	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
370438006647	putative active site pocket [active]
370438006648	dimerization interface [polypeptide binding]; other site
370438006649	putative catalytic residue [active]
370438006650	Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224
370438006651	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267
370438006652	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
370438006653	Walker A/P-loop; other site
370438006654	ATP binding site [chemical binding]; other site
370438006655	ABC transporter signature motif; other site
370438006656	Walker B; other site
370438006657	D-loop; other site
370438006658	H-loop/switch region; other site
370438006659	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
370438006660	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
370438006661	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
370438006662	P-loop; other site
370438006663	Magnesium ion binding site [ion binding]; other site
370438006664	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
370438006665	Magnesium ion binding site [ion binding]; other site
370438006666	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
370438006667	Transposase domain (DUF772); Region: DUF772; pfam05598
370438006668	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
370438006669	HTH domain; Region: HTH_11; cl17392
370438006670	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
370438006671	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
370438006672	Protein of unknown function (DUF1256); Region: DUF1256; cl06087
370438006673	Protein of unknown function (DUF1444); Region: DUF1444; cl02011
370438006674	Macro domain, Unknown family 2. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose polymerases)...; Region: Macro_2; cd03330
370438006675	putative ADP-ribose binding site [chemical binding]; other site
370438006676	Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_4; cd04501
370438006677	active site
370438006678	catalytic triad [active]
370438006679	oxyanion hole [active]
370438006680	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
370438006681	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
370438006682	pyruvate kinase; Provisional; Region: PRK06354
370438006683	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
370438006684	domain interfaces; other site
370438006685	active site
370438006686	Phosphohistidine swiveling domain [Signal transduction mechanisms]; Region: COG3848
370438006687	6-phosphofructokinase; Provisional; Region: PRK03202
370438006688	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
370438006689	active site
370438006690	ADP/pyrophosphate binding site [chemical binding]; other site
370438006691	dimerization interface [polypeptide binding]; other site
370438006692	allosteric effector site; other site
370438006693	fructose-1,6-bisphosphate binding site; other site
370438006694	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
370438006695	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
370438006696	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
370438006697	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
370438006698	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
370438006699	transcription attenuation protein MtrB; Provisional; Region: PRK13251
370438006700	DNA polymerase III DnaE; Reviewed; Region: dnaE; PRK06826
370438006701	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113
370438006702	active site
370438006703	PHP Thumb interface [polypeptide binding]; other site
370438006704	metal binding site [ion binding]; metal-binding site
370438006705	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
370438006706	generic binding surface II; other site
370438006707	generic binding surface I; other site
370438006708	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
370438006709	dimerization interface [polypeptide binding]; other site
370438006710	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
370438006711	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
370438006712	dimer interface [polypeptide binding]; other site
370438006713	putative CheW interface [polypeptide binding]; other site
370438006714	Uncharacterized conserved protein [Function unknown]; Region: COG3287
370438006715	FIST N domain; Region: FIST; pfam08495
370438006716	FIST C domain; Region: FIST_C; pfam10442
370438006717	This CD, composed mainly of bacterial single-domain proteins, includes the Thermus thermophilus (Tt) YbaK-like protein, a homolog of the trans-acting Escherichia coli YbaK Cys-tRNA(Pro) deacylase and the Agrobacterium tumefaciens  ProX Ala-tRNA(Pro)...; Region: ProX_deacylase; cd04333
370438006718	putative deacylase active site [active]
370438006719	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
370438006720	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
370438006721	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
370438006722	minor groove reading motif; other site
370438006723	helix-hairpin-helix signature motif; other site
370438006724	substrate binding pocket [chemical binding]; other site
370438006725	active site
370438006726	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
370438006727	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
370438006728	Uncharacterized conserved protein [Function unknown]; Region: COG1543
370438006729	N-terminal catalytic domain of  alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792
370438006730	active site
370438006731	substrate binding site [chemical binding]; other site
370438006732	catalytic site [active]
370438006733	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
370438006734	L-lactate permease; Region: Lactate_perm; cl00701
370438006735	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
370438006736	FAD binding domain; Region: FAD_binding_4; pfam01565
370438006737	glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387
370438006738	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
370438006739	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
370438006740	Cysteine-rich domain; Region: CCG; pfam02754
370438006741	Cysteine-rich domain; Region: CCG; pfam02754
370438006742	Transcriptional regulators [Transcription]; Region: FadR; COG2186
370438006743	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
370438006744	DNA-binding site [nucleotide binding]; DNA binding site
370438006745	FCD domain; Region: FCD; pfam07729
370438006746	Transcriptional regulators [Transcription]; Region: FadR; COG2186
370438006747	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
370438006748	DNA-binding site [nucleotide binding]; DNA binding site
370438006749	FCD domain; Region: FCD; pfam07729
370438006750	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
370438006751	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
370438006752	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
370438006753	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
370438006754	Cysteine-rich domain; Region: CCG; pfam02754
370438006755	Cysteine-rich domain; Region: CCG; pfam02754
370438006756	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
370438006757	BioD-like N-terminal domain of phosphotransacetylase [General function prediction only]; Region: Pta; COG0857
370438006758	Dethiobiotin synthetase [Coenzyme metabolism]; Region: BioD; COG0132
370438006759	DRTGG domain; Region: DRTGG; pfam07085
370438006760	acetyl coenzyme A synthetase (ADP forming), alpha domain; Region: AcCoA-syn-alpha; TIGR02717
370438006761	CoA binding domain; Region: CoA_binding_2; pfam13380
370438006762	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
370438006763	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
370438006764	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
370438006765	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
370438006766	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
370438006767	putative trimer interface [polypeptide binding]; other site
370438006768	putative CoA binding site [chemical binding]; other site
370438006769	phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990
370438006770	GTP-mannose-1-phosphate guanyltransferase (MPG1 transferase), also known as GDP-mannose pyrophosphorylase, is a bifunctional enzyme with both phosphomannose isomerase (PMI) activity and GDP-mannose phosphorylase (GMP) activity.  The protein contains an...; Region: MPG1_transferase; cd05805
370438006771	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
370438006772	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
370438006773	catalytic residues [active]
370438006774	catalytic nucleophile [active]
370438006775	Recombinase; Region: Recombinase; pfam07508
370438006776	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
370438006777	Uncharacterized protein family (UPF0236); Region: UPF0236; pfam06782
370438006778	Transposase; Region: DDE_Tnp_ISL3; pfam01610
370438006779	Abi-like protein; Region: Abi_2; cl01988
370438006780	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
370438006781	Zn2+ binding site [ion binding]; other site
370438006782	Mg2+ binding site [ion binding]; other site
370438006783	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
370438006784	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
370438006785	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
370438006786	Soluble P-type ATPase [General function prediction only]; Region: COG4087
370438006787	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
370438006788	Low molecular weight phosphatase family; Region: LMWPc; cl00105
370438006789	Putative Fe-S cluster; Region: FeS; cl17515
370438006790	FOG: CBS domain [General function prediction only]; Region: COG0517
370438006791	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
370438006792	sensory histidine kinase AtoS; Provisional; Region: PRK11360
370438006793	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
370438006794	putative active site [active]
370438006795	heme pocket [chemical binding]; other site
370438006796	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
370438006797	phosphorylation site [posttranslational modification]
370438006798	dimer interface [polypeptide binding]; other site
370438006799	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
370438006800	ATP binding site [chemical binding]; other site
370438006801	Mg2+ binding site [ion binding]; other site
370438006802	G-X-G motif; other site
370438006803	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
370438006804	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370438006805	active site
370438006806	phosphorylation site [posttranslational modification]
370438006807	intermolecular recognition site; other site
370438006808	dimerization interface [polypeptide binding]; other site
370438006809	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438006810	Walker A motif; other site
370438006811	ATP binding site [chemical binding]; other site
370438006812	Walker B motif; other site
370438006813	arginine finger; other site
370438006814	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
370438006815	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
370438006816	Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608
370438006817	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
370438006818	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
370438006819	Walker A/P-loop; other site
370438006820	ATP binding site [chemical binding]; other site
370438006821	Q-loop/lid; other site
370438006822	ABC transporter signature motif; other site
370438006823	Walker B; other site
370438006824	D-loop; other site
370438006825	H-loop/switch region; other site
370438006826	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
370438006827	dimer interface [polypeptide binding]; other site
370438006828	conserved gate region; other site
370438006829	putative PBP binding loops; other site
370438006830	ABC-ATPase subunit interface; other site
370438006831	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
370438006832	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370438006833	FeS/SAM binding site; other site
370438006834	RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2
370438006835	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
370438006836	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
370438006837	DNA binding residues [nucleotide binding]
370438006838	xanthine permease; Region: pbuX; TIGR03173
370438006839	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
370438006840	anti sigma factor interaction site; other site
370438006841	regulatory phosphorylation site [posttranslational modification]; other site
370438006842	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
370438006843	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
370438006844	ATP binding site [chemical binding]; other site
370438006845	Mg2+ binding site [ion binding]; other site
370438006846	G-X-G motif; other site
370438006847	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
370438006848	Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208
370438006849	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
370438006850	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
370438006851	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
370438006852	anti sigma factor interaction site; other site
370438006853	regulatory phosphorylation site [posttranslational modification]; other site
370438006854	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
370438006855	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
370438006856	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
370438006857	Walker A/P-loop; other site
370438006858	ATP binding site [chemical binding]; other site
370438006859	Q-loop/lid; other site
370438006860	ABC transporter signature motif; other site
370438006861	Walker B; other site
370438006862	D-loop; other site
370438006863	H-loop/switch region; other site
370438006864	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
370438006865	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
370438006866	ABC transporter signature motif; other site
370438006867	Walker B; other site
370438006868	D-loop; other site
370438006869	H-loop/switch region; other site
370438006870	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
370438006871	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_13; cd06348
370438006872	putative ligand binding site [chemical binding]; other site
370438006873	D-ala-D-ala dipeptidase; Region: Peptidase_M15; cl00813
370438006874	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
370438006875	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
370438006876	Glycosyl hydrolase family 3 C-terminal domain; Region: Glyco_hydro_3_C; pfam01915
370438006877	radical SAM/SPASM domain Clo7bot peptide maturase; Region: rSAM_Clo7bot; TIGR04334
370438006878	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370438006879	FeS/SAM binding site; other site
370438006880	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
370438006881	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
370438006882	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
370438006883	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
370438006884	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
370438006885	DNA binding residues [nucleotide binding]
370438006886	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
370438006887	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
370438006888	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
370438006889	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
370438006890	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
370438006891	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
370438006892	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
370438006893	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
370438006894	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
370438006895	transmembrane helices; other site
370438006896	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
370438006897	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
370438006898	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
370438006899	active site
370438006900	DNA binding site [nucleotide binding]
370438006901	Int/Topo IB signature motif; other site
370438006902	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
370438006903	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
370438006904	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
370438006905	active site
370438006906	DNA binding site [nucleotide binding]
370438006907	Int/Topo IB signature motif; other site
370438006908	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
370438006909	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
370438006910	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
370438006911	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
370438006912	nif11-like leader peptide domain; Region: ocin_TIGR03798
370438006913	Nitrogen fixation protein of unknown function; Region: Nif11; cl06756
370438006914	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
370438006915	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
370438006916	putative active site [active]
370438006917	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
370438006918	putative active site [active]
370438006919	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
370438006920	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
370438006921	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
370438006922	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
370438006923	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
370438006924	Nitrogen fixation protein of unknown function; Region: Nif11; cl06756
370438006925	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
370438006926	Peptidase family M23; Region: Peptidase_M23; pfam01551
370438006927	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
370438006928	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
370438006929	D-galactonate transporter; Region: 2A0114; TIGR00893
370438006930	putative substrate translocation pore; other site
370438006931	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408
370438006932	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; cl01408
370438006933	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
370438006934	guanine deaminase; Region: guan_deamin; TIGR02967
370438006935	active site
370438006936	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
370438006937	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
370438006938	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
370438006939	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
370438006940	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
370438006941	Transposase [DNA replication, recombination, and repair]; Region: COG5421
370438006942	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
370438006943	bacteriocin biosynthesis cyclodehydratase domain; Region: cyclo_dehyd_2; TIGR03882
370438006944	YcaO-like family; Region: YcaO; pfam02624
370438006945	thiazole/oxazole-forming peptide maturase, SagD family component; Region: TOMM_cyclo_SagD; TIGR03604
370438006946	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
370438006947	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
370438006948	Walker A/P-loop; other site
370438006949	ATP binding site [chemical binding]; other site
370438006950	Q-loop/lid; other site
370438006951	ABC transporter signature motif; other site
370438006952	Walker B; other site
370438006953	D-loop; other site
370438006954	H-loop/switch region; other site
370438006955	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
370438006956	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
370438006957	substrate binding pocket [chemical binding]; other site
370438006958	membrane-bound complex binding site; other site
370438006959	hinge residues; other site
370438006960	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
370438006961	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
370438006962	substrate binding pocket [chemical binding]; other site
370438006963	membrane-bound complex binding site; other site
370438006964	hinge residues; other site
370438006965	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
370438006966	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
370438006967	substrate binding pocket [chemical binding]; other site
370438006968	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
370438006969	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
370438006970	dimer interface [polypeptide binding]; other site
370438006971	conserved gate region; other site
370438006972	putative PBP binding loops; other site
370438006973	ABC-ATPase subunit interface; other site
370438006974	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
370438006975	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
370438006976	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
370438006977	active site
370438006978	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
370438006979	Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775
370438006980	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
370438006981	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
370438006982	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
370438006983	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370438006984	Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641
370438006985	FeS/SAM binding site; other site
370438006986	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
370438006987	radical SAM/SPASM domain Clo7bot peptide maturase; Region: rSAM_Clo7bot; TIGR04334
370438006988	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
370438006989	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
370438006990	Walker A/P-loop; other site
370438006991	ATP binding site [chemical binding]; other site
370438006992	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
370438006993	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
370438006994	Walker A/P-loop; other site
370438006995	ATP binding site [chemical binding]; other site
370438006996	Q-loop/lid; other site
370438006997	ABC transporter signature motif; other site
370438006998	Walker B; other site
370438006999	D-loop; other site
370438007000	H-loop/switch region; other site
370438007001	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
370438007002	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
370438007003	TM-ABC transporter signature motif; other site
370438007004	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
370438007005	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
370438007006	TM-ABC transporter signature motif; other site
370438007007	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
370438007008	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_13; cd06348
370438007009	putative ligand binding site [chemical binding]; other site
370438007010	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
370438007011	Nitrogen fixation protein of unknown function; Region: Nif11; cl06756
370438007012	Nitrogen fixation protein of unknown function; Region: Nif11; pfam07862
370438007013	Nitrogen fixation protein of unknown function; Region: Nif11; cl06756
370438007014	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
370438007015	Transposase, Mutator family; Region: Transposase_mut; pfam00872
370438007016	MULE transposase domain; Region: MULE; pfam10551
370438007017	Alpha-acetolactate decarboxylase; Region: AAL_decarboxy; pfam03306
370438007018	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
370438007019	guanine deaminase; Region: guan_deamin; TIGR02967
370438007020	active site
370438007021	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
370438007022	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
370438007023	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
370438007024	Chagasin family peptidase inhibitor I42; Region: Inhibitor_I42; pfam09394
370438007025	S-layer homology domain; Region: SLH; pfam00395
370438007026	S-layer homology domain; Region: SLH; pfam00395
370438007027	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
370438007028	Acyl-CoA thioester hydrolase/BAAT N-terminal region; Region: Bile_Hydr_Trans; pfam04775
370438007029	BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840
370438007030	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
370438007031	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
370438007032	Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845
370438007033	active site
370438007034	metal binding site [ion binding]; metal-binding site
370438007035	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
370438007036	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
370438007037	nif11-like leader peptide domain; Region: ocin_TIGR03798
370438007038	radical SAM/SPASM domain Clo7bot peptide maturase; Region: rSAM_Clo7bot; TIGR04334
370438007039	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370438007040	FeS/SAM binding site; other site
370438007041	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
370438007042	Nitrogen fixation protein of unknown function; Region: Nif11; cl06756
370438007043	nif11-like peptide radical SAM maturase; Region: rSAM_nif11; TIGR04064
370438007044	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
370438007045	nif11-like peptide radical SAM maturase; Region: rSAM_nif11; TIGR04064
370438007046	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370438007047	FeS/SAM binding site; other site
370438007048	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
370438007049	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
370438007050	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
370438007051	S-adenosylmethionine binding site [chemical binding]; other site
370438007052	phosphoenolpyruvate synthase; Validated; Region: PRK06241
370438007053	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
370438007054	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
370438007055	NHLM bacteriocin system ABC transporter, ATP-binding protein; Region: NHLM_micro_ABC2; TIGR03797
370438007056	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
370438007057	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
370438007058	Walker A/P-loop; other site
370438007059	ATP binding site [chemical binding]; other site
370438007060	Q-loop/lid; other site
370438007061	ABC transporter signature motif; other site
370438007062	Walker B; other site
370438007063	D-loop; other site
370438007064	H-loop/switch region; other site
370438007065	NHLM bacteriocin system ABC transporter, peptidase/ATP-binding protein; Region: NHLM_micro_ABC1; TIGR03796
370438007066	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39D; cd02420
370438007067	putative active site [active]
370438007068	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
370438007069	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
370438007070	Walker A/P-loop; other site
370438007071	ATP binding site [chemical binding]; other site
370438007072	Q-loop/lid; other site
370438007073	ABC transporter signature motif; other site
370438007074	Walker B; other site
370438007075	D-loop; other site
370438007076	H-loop/switch region; other site
370438007077	NHLM bacteriocin system secretion protein; Region: NHLM_micro_HlyD; TIGR03794
370438007078	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
370438007079	HlyD family secretion protein; Region: HlyD_3; pfam13437
370438007080	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
370438007081	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
370438007082	RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2
370438007083	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
370438007084	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
370438007085	DNA binding residues [nucleotide binding]
370438007086	7TM diverse intracellular signalling; Region: 7TMR-DISM_7TM; pfam07695
370438007087	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
370438007088	dimer interface [polypeptide binding]; other site
370438007089	phosphorylation site [posttranslational modification]
370438007090	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
370438007091	ATP binding site [chemical binding]; other site
370438007092	Mg2+ binding site [ion binding]; other site
370438007093	G-X-G motif; other site
370438007094	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
370438007095	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370438007096	active site
370438007097	phosphorylation site [posttranslational modification]
370438007098	intermolecular recognition site; other site
370438007099	dimerization interface [polypeptide binding]; other site
370438007100	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
370438007101	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
370438007102	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370438007103	active site
370438007104	phosphorylation site [posttranslational modification]
370438007105	intermolecular recognition site; other site
370438007106	dimerization interface [polypeptide binding]; other site
370438007107	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
370438007108	DNA binding site [nucleotide binding]
370438007109	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
370438007110	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
370438007111	Coenzyme A binding pocket [chemical binding]; other site
370438007112	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
370438007113	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
370438007114	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569
370438007115	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
370438007116	DNA-binding interface [nucleotide binding]; DNA binding site
370438007117	Integrase core domain; Region: rve; pfam00665
370438007118	Integrase core domain; Region: rve_3; cl15866
370438007119	transposase; Provisional; Region: PRK06526
370438007120	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438007121	Walker A motif; other site
370438007122	ATP binding site [chemical binding]; other site
370438007123	Walker B motif; other site
370438007124	arginine finger; other site
370438007125	Transposase, Mutator family; Region: Transposase_mut; pfam00872
370438007126	MULE transposase domain; Region: MULE; pfam10551
370438007127	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
370438007128	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
370438007129	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
370438007130	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
370438007131	Transposase; Region: DEDD_Tnp_IS110; pfam01548
370438007132	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
370438007133	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
370438007134	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
370438007135	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
370438007136	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
370438007137	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
370438007138	Protein of unknown function DUF45; Region: DUF45; cl00636
370438007139	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG1483
370438007140	Protein of unknown function (DUF499); Region: DUF499; pfam04465
370438007141	Adenine-specific DNA methylase containing a Zn-ribbon [DNA replication, recombination, and repair]; Region: COG1743
370438007142	Homeodomain-like domain; Region: HTH_23; pfam13384
370438007143	Winged helix-turn helix; Region: HTH_29; pfam13551
370438007144	Homeodomain-like domain; Region: HTH_32; pfam13565
370438007145	Integrase core domain; Region: rve; pfam00665
370438007146	Integrase core domain; Region: rve_3; pfam13683
370438007147	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
370438007148	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
370438007149	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
370438007150	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
370438007151	Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231
370438007152	catalytic Zn binding site [ion binding]; other site
370438007153	structural Zn binding site [ion binding]; other site
370438007154	tetramer interface [polypeptide binding]; other site
370438007155	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
370438007156	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
370438007157	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
370438007158	Transposase domain (DUF772); Region: DUF772; pfam05598
370438007159	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
370438007160	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
370438007161	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
370438007162	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
370438007163	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
370438007164	putative active site [active]
370438007165	putative NTP binding site [chemical binding]; other site
370438007166	putative nucleic acid binding site [nucleotide binding]; other site
370438007167	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
370438007168	MULE transposase domain; Region: MULE; pfam10551
370438007169	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
370438007170	Integrase core domain; Region: rve; pfam00665
370438007171	DDE domain; Region: DDE_Tnp_IS240; pfam13610
370438007172	Integrase core domain; Region: rve_3; pfam13683
370438007173	Transposase; Region: HTH_Tnp_1; pfam01527
370438007174	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
370438007175	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
370438007176	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
370438007177	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
370438007178	putative active site [active]
370438007179	putative NTP binding site [chemical binding]; other site
370438007180	putative nucleic acid binding site [nucleotide binding]; other site
370438007181	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
370438007182	B12 binding domain of glutamate mutase (Glm). Glutamate mutase catalysis the conversion of (S)-glutamate with (2S,3S)-3-methylaspartate. The rearrangement reaction is initiated by the extraction of a hydrogen from the protein-bound substrate by a 5'...; Region: Glm_B12_BD; cd02072
370438007183	B12 binding site [chemical binding]; other site
370438007184	heterodimer interface [polypeptide binding]; other site
370438007185	cobalt ligand [ion binding]; other site
370438007186	Coenzyme B12-dependent glutamate mutase epsilon subunit-like family; contains proteins similar to Clostridium cochlearium glutamate mutase (Glm) and Streptomyces tendae Tu901 NikV. Glm catalyzes a carbon-skeleton rearrangement of L-glutamate to...; Region: Glm_e; cd00245
370438007187	substrate binding site [chemical binding]; other site
370438007188	B12 cofactor binding site [chemical binding]; other site
370438007189	heterodimer (sigma-epsilon) interface [polypeptide binding]; other site
370438007190	homodimer (epsilon-epsilon) interface [polypeptide binding]; other site
370438007191	glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494
370438007192	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
370438007193	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
370438007194	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370438007195	FeS/SAM binding site; other site
370438007196	Major Facilitator Superfamily; Region: MFS_1; pfam07690
370438007197	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
370438007198	putative substrate translocation pore; other site
370438007199	NAD(P)H:flavin oxidoreductase-like family 1.  A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes; Region: NADPH_oxidoreductase_1; cd02150
370438007200	putative FMN binding site [chemical binding]; other site
370438007201	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
370438007202	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801
370438007203	Integrase core domain; Region: rve; pfam00665
370438007204	Integrase core domain; Region: rve_3; cl15866
370438007205	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
370438007206	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
370438007207	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438007208	Walker A motif; other site
370438007209	ATP binding site [chemical binding]; other site
370438007210	Walker B motif; other site
370438007211	arginine finger; other site
370438007212	Coenzyme A transferase; Region: CoA_trans; smart00882
370438007213	Coenzyme A transferase; Region: CoA_trans; cl17247
370438007214	oxidoreductase; Provisional; Region: PRK10015
370438007215	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
370438007216	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
370438007217	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985
370438007218	Ligand binding site [chemical binding]; other site
370438007219	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
370438007220	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
370438007221	Ligand binding site [chemical binding]; other site
370438007222	Electron transfer flavoprotein domain; Region: ETF; pfam01012
370438007223	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
370438007224	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
370438007225	active site
370438007226	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
370438007227	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
370438007228	active site
370438007229	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
370438007230	MutL protein; Region: MutL; pfam13941
370438007231	glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774
370438007232	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
370438007233	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
370438007234	Transposase; Region: DEDD_Tnp_IS110; pfam01548
370438007235	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
370438007236	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
370438007237	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438007238	Walker A motif; other site
370438007239	ATP binding site [chemical binding]; other site
370438007240	Walker B motif; other site
370438007241	arginine finger; other site
370438007242	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
370438007243	DDE superfamily endonuclease; Region: DDE_5; cl17874
370438007244	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
370438007245	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
370438007246	ATP binding site [chemical binding]; other site
370438007247	putative Mg++ binding site [ion binding]; other site
370438007248	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
370438007249	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
370438007250	nucleotide binding region [chemical binding]; other site
370438007251	ATP-binding site [chemical binding]; other site
370438007252	Domain of unknown function (DUF3883); Region: DUF3883; pfam13020
370438007253	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
370438007254	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
370438007255	non-specific DNA binding site [nucleotide binding]; other site
370438007256	salt bridge; other site
370438007257	sequence-specific DNA binding site [nucleotide binding]; other site
370438007258	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
370438007259	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
370438007260	catalytic residues [active]
370438007261	catalytic nucleophile [active]
370438007262	Presynaptic Site I dimer interface [polypeptide binding]; other site
370438007263	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
370438007264	Synaptic Flat tetramer interface [polypeptide binding]; other site
370438007265	Synaptic Site I dimer interface [polypeptide binding]; other site
370438007266	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5304
370438007267	Transposase, Mutator family; Region: Transposase_mut; pfam00872
370438007268	MULE transposase domain; Region: MULE; pfam10551
370438007269	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
370438007270	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
370438007271	active site
370438007272	DNA binding site [nucleotide binding]
370438007273	Int/Topo IB signature motif; other site
370438007274	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
370438007275	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
370438007276	active site
370438007277	DNA binding site [nucleotide binding]
370438007278	Int/Topo IB signature motif; other site
370438007279	non-LTR RNase HI domain of reverse transcriptases; Region: Rnase_HI_RT_non_LTR; cd09276
370438007280	RNA/DNA hybrid binding site [nucleotide binding]; other site
370438007281	active site
370438007282	Fic family protein [Function unknown]; Region: COG3177
370438007283	Fic/DOC family; Region: Fic; pfam02661
370438007284	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
370438007285	Zn binding site [ion binding]; other site
370438007286	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
370438007287	MPN+ (JAMM) motif; other site
370438007288	Zinc-binding site [ion binding]; other site
370438007289	PD-(D/E)XK nuclease family transposase; Region: PDDEXK_2; pfam12784
370438007290	Mitochondrial inner membrane protein; Region: Mitofilin; pfam09731
370438007291	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
370438007292	metal binding site [ion binding]; metal-binding site
370438007293	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
370438007294	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
370438007295	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
370438007296	putative active site [active]
370438007297	putative NTP binding site [chemical binding]; other site
370438007298	putative nucleic acid binding site [nucleotide binding]; other site
370438007299	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
370438007300	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
370438007301	putative active site [active]
370438007302	putative NTP binding site [chemical binding]; other site
370438007303	putative nucleic acid binding site [nucleotide binding]; other site
370438007304	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
370438007305	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868
370438007306	P22_AR N-terminal domain; Region: P22_AR_N; pfam10547
370438007307	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06676
370438007308	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
370438007309	RNA binding site [nucleotide binding]; other site
370438007310	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
370438007311	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; cl00868
370438007312	stage V sporulation protein K; Region: spore_V_K; TIGR02881
370438007313	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438007314	Walker A motif; other site
370438007315	ATP binding site [chemical binding]; other site
370438007316	Walker B motif; other site
370438007317	arginine finger; other site
370438007318	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
370438007319	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
370438007320	Walker A motif; other site
370438007321	ATP binding site [chemical binding]; other site
370438007322	Walker B motif; other site
370438007323	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
370438007324	IHF dimer interface [polypeptide binding]; other site
370438007325	IHF - DNA interface [nucleotide binding]; other site
370438007326	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
370438007327	Antitoxin of toxin-antitoxin stability system N-terminal; Region: RelB_N; pfam12910
370438007328	Protein of unknown function (DUF3832); Region: DUF3832; pfam12909
370438007329	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
370438007330	non-specific DNA binding site [nucleotide binding]; other site
370438007331	salt bridge; other site
370438007332	sequence-specific DNA binding site [nucleotide binding]; other site
370438007333	Protein of unknown function (DUF3832); Region: DUF3832; pfam12909
370438007334	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
370438007335	IHF dimer interface [polypeptide binding]; other site
370438007336	IHF - DNA interface [nucleotide binding]; other site
370438007337	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257
370438007338	Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859
370438007339	polymerase nucleotide-binding site; other site
370438007340	DNA-binding residues [nucleotide binding]; DNA binding site
370438007341	nucleotide binding site [chemical binding]; other site
370438007342	primase nucleotide-binding site [nucleotide binding]; other site
370438007343	Primase C terminal 1 (PriCT-1); Region: PriCT_1; smart00942
370438007344	DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796
370438007345	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
370438007346	Walker A motif; other site
370438007347	ATP binding site [chemical binding]; other site
370438007348	Walker B motif; other site
370438007349	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
370438007350	Transposase IS200 like; Region: Y1_Tnp; pfam01797
370438007351	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
370438007352	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
370438007353	NTP_transferases catalyze the transfer of nucleotides onto phosphosugars; Region: NTP_transferase; cd04181
370438007354	active site
370438007355	Substrate binding site; other site
370438007356	Mg++ binding site; other site
370438007357	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
370438007358	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
370438007359	Carbohydrate binding domain; Region: CBM_25; smart01066
370438007360	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
370438007361	tartrate dehydrogenase; Region: TTC; TIGR02089
370438007362	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
370438007363	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
370438007364	substrate binding site [chemical binding]; other site
370438007365	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
370438007366	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
370438007367	substrate binding site [chemical binding]; other site
370438007368	ligand binding site [chemical binding]; other site
370438007369	trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858
370438007370	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
370438007371	active site
370438007372	catalytic residues [active]
370438007373	metal binding site [ion binding]; metal-binding site
370438007374	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
370438007375	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
370438007376	GatB domain; Region: GatB_Yqey; smart00845
370438007377	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
370438007378	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
370438007379	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
370438007380	FOG: CBS domain [General function prediction only]; Region: COG0517
370438007381	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_23; cd04636
370438007382	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
370438007383	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
370438007384	putative substrate translocation pore; other site
370438007385	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
370438007386	Transposase [DNA replication, recombination, and repair]; Region: COG5421
370438007387	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
370438007388	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
370438007389	nucleotide binding pocket [chemical binding]; other site
370438007390	K-X-D-G motif; other site
370438007391	catalytic site [active]
370438007392	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
370438007393	Helix-hairpin-helix motif; Region: HHH; pfam00633
370438007394	helix-hairpin-helix signature motif; other site
370438007395	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
370438007396	Dimer interface [polypeptide binding]; other site
370438007397	BRCT sequence motif; other site
370438007398	Protein of unknown function (DUF2837); Region: DUF2837; pfam10997
370438007399	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
370438007400	Part of AAA domain; Region: AAA_19; pfam13245
370438007401	Family description; Region: UvrD_C_2; pfam13538
370438007402	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
370438007403	metal binding site [ion binding]; metal-binding site
370438007404	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
370438007405	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
370438007406	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
370438007407	substrate binding site [chemical binding]; other site
370438007408	glutamase interaction surface [polypeptide binding]; other site
370438007409	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
370438007410	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
370438007411	catalytic residues [active]
370438007412	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141
370438007413	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
370438007414	putative active site [active]
370438007415	oxyanion strand; other site
370438007416	catalytic triad [active]
370438007417	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
370438007418	putative active site pocket [active]
370438007419	4-fold oligomerization interface [polypeptide binding]; other site
370438007420	metal binding residues [ion binding]; metal-binding site
370438007421	3-fold/trimer interface [polypeptide binding]; other site
370438007422	histidinol-phosphate aminotransferase; Region: hisC; TIGR01141
370438007423	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
370438007424	pyridoxal 5'-phosphate binding site [chemical binding]; other site
370438007425	homodimer interface [polypeptide binding]; other site
370438007426	catalytic residue [active]
370438007427	histidinol dehydrogenase; Region: hisD; TIGR00069
370438007428	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
370438007429	NAD binding site [chemical binding]; other site
370438007430	dimerization interface [polypeptide binding]; other site
370438007431	product binding site; other site
370438007432	substrate binding site [chemical binding]; other site
370438007433	zinc binding site [ion binding]; other site
370438007434	catalytic residues [active]
370438007435	Trp repressor protein; Region: Trp_repressor; cl17266
370438007436	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
370438007437	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
370438007438	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
370438007439	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
370438007440	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
370438007441	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
370438007442	purine monophosphate binding site [chemical binding]; other site
370438007443	dimer interface [polypeptide binding]; other site
370438007444	putative catalytic residues [active]
370438007445	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
370438007446	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
370438007447	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
370438007448	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
370438007449	active site
370438007450	substrate binding site [chemical binding]; other site
370438007451	cosubstrate binding site; other site
370438007452	catalytic site [active]
370438007453	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
370438007454	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
370438007455	dimerization interface [polypeptide binding]; other site
370438007456	putative ATP binding site [chemical binding]; other site
370438007457	amidophosphoribosyltransferase; Provisional; Region: PRK05793
370438007458	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
370438007459	active site
370438007460	tetramer interface [polypeptide binding]; other site
370438007461	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
370438007462	active site
370438007463	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
370438007464	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
370438007465	ATP binding site [chemical binding]; other site
370438007466	active site
370438007467	substrate binding site [chemical binding]; other site
370438007468	adenylosuccinate lyase; Provisional; Region: PRK07492
370438007469	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
370438007470	tetramer interface [polypeptide binding]; other site
370438007471	active site
370438007472	AIR carboxylase; Region: AIRC; pfam00731
370438007473	PIN domain of the hypothetical protein MT3492 of Mycobacterium tuberculosis CDC1551 and other uncharacterized, annotated PilT protein domain proteins; Region: PIN_MT3492; cd09874
370438007474	putative active site [active]
370438007475	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118
370438007476	GMP synthase; Reviewed; Region: guaA; PRK00074
370438007477	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
370438007478	AMP/PPi binding site [chemical binding]; other site
370438007479	candidate oxyanion hole; other site
370438007480	catalytic triad [active]
370438007481	potential glutamine specificity residues [chemical binding]; other site
370438007482	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
370438007483	ATP Binding subdomain [chemical binding]; other site
370438007484	Ligand Binding sites [chemical binding]; other site
370438007485	Dimerization subdomain; other site
370438007486	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
370438007487	active site
370438007488	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain putative pyrophosphatase YpjD from Bacillus subtilis and its bacterial homologs; Region: NTP-PPase_BsYpjD; cd11531
370438007489	homodimer interface [polypeptide binding]; other site
370438007490	metal binding site [ion binding]; metal-binding site
370438007491	Uncharacterized conserved protein [Function unknown]; Region: COG4198
370438007492	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
370438007493	Uncharacterized conserved protein [Function unknown]; Region: COG4198
370438007494	Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260
370438007495	putative active site [active]
370438007496	PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB-like; cd09875
370438007497	putative active site [active]
370438007498	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
370438007499	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
370438007500	Zn2+ binding site [ion binding]; other site
370438007501	Mg2+ binding site [ion binding]; other site
370438007502	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
370438007503	Bacterial sugar transferase; Region: Bac_transf; pfam02397
370438007504	This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808
370438007505	Glycosyltransferase Family 4; Region: Glyco_transf_4; pfam13439
370438007506	putative ADP-binding pocket [chemical binding]; other site
370438007507	HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078
370438007508	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
370438007509	Zn2+ binding site [ion binding]; other site
370438007510	Mg2+ binding site [ion binding]; other site
370438007511	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
370438007512	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
370438007513	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
370438007514	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
370438007515	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370438007516	FeS/SAM binding site; other site
370438007517	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
370438007518	Methyltransferase domain; Region: Methyltransf_11; pfam08241
370438007519	Transposase domain (DUF772); Region: DUF772; pfam05598
370438007520	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
370438007521	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
370438007522	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
370438007523	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
370438007524	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
370438007525	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
370438007526	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
370438007527	inhibitor-cofactor binding pocket; inhibition site
370438007528	pyridoxal 5'-phosphate binding site [chemical binding]; other site
370438007529	catalytic residue [active]
370438007530	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
370438007531	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
370438007532	Walker A/P-loop; other site
370438007533	ATP binding site [chemical binding]; other site
370438007534	Q-loop/lid; other site
370438007535	ABC transporter signature motif; other site
370438007536	Walker B; other site
370438007537	D-loop; other site
370438007538	H-loop/switch region; other site
370438007539	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
370438007540	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
370438007541	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
370438007542	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
370438007543	NADP binding site [chemical binding]; other site
370438007544	active site
370438007545	putative substrate binding site [chemical binding]; other site
370438007546	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
370438007547	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
370438007548	NAD binding site [chemical binding]; other site
370438007549	substrate binding site [chemical binding]; other site
370438007550	homodimer interface [polypeptide binding]; other site
370438007551	active site
370438007552	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
370438007553	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
370438007554	active site
370438007555	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
370438007556	Myxococcus xanthus RfbC like proteins are required for O-antigen biosynthesis; Region: GT2_RfbC_Mx_like; cd04184
370438007557	Probable Catalytic site; other site
370438007558	metal-binding site
370438007559	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
370438007560	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
370438007561	Probable Catalytic site; other site
370438007562	metal-binding site
370438007563	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
370438007564	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
370438007565	putative homodimer interface [polypeptide binding]; other site
370438007566	O-Antigen ligase; Region: Wzy_C; cl04850
370438007567	O-Antigen ligase; Region: Wzy_C; pfam04932
370438007568	TPR repeat; Region: TPR_11; pfam13414
370438007569	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
370438007570	TPR motif; other site
370438007571	binding surface
370438007572	TPR repeat; Region: TPR_11; pfam13414
370438007573	Tetratricopeptide repeat; Region: TPR_12; pfam13424
370438007574	Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403
370438007575	active site
370438007576	NTP binding site [chemical binding]; other site
370438007577	metal binding triad [ion binding]; metal-binding site
370438007578	antibiotic binding site [chemical binding]; other site
370438007579	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
370438007580	CHASE3 domain; Region: CHASE3; cl05000
370438007581	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
370438007582	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
370438007583	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
370438007584	dimerization interface [polypeptide binding]; other site
370438007585	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
370438007586	dimer interface [polypeptide binding]; other site
370438007587	putative CheW interface [polypeptide binding]; other site
370438007588	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
370438007589	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
370438007590	non-specific DNA binding site [nucleotide binding]; other site
370438007591	salt bridge; other site
370438007592	sequence-specific DNA binding site [nucleotide binding]; other site
370438007593	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
370438007594	putative substrate translocation pore; other site
370438007595	Major Facilitator Superfamily; Region: MFS_1; pfam07690
370438007596	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685
370438007597	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
370438007598	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
370438007599	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
370438007600	putative catalytic cysteine [active]
370438007601	Uncharacterized conserved protein [Function unknown]; Region: COG5663
370438007602	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
370438007603	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
370438007604	dimer interface [polypeptide binding]; other site
370438007605	pyridoxal 5'-phosphate binding site [chemical binding]; other site
370438007606	catalytic residue [active]
370438007607	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
370438007608	dimer interface [polypeptide binding]; other site
370438007609	putative CheW interface [polypeptide binding]; other site
370438007610	Radical SAM superfamily; Region: Radical_SAM; pfam04055
370438007611	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370438007612	FeS/SAM binding site; other site
370438007613	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
370438007614	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
370438007615	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
370438007616	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
370438007617	Leucine-zipper of ternary complex factor MIP1; Region: Lzipper-MIP1; pfam14389
370438007618	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
370438007619	Double zinc ribbon; Region: DZR; pfam12773
370438007620	RNAse HI family that includes Archaeal RNase HI; Region: RNase_HI_archaeal_like; cd09279
370438007621	RNA/DNA hybrid binding site [nucleotide binding]; other site
370438007622	active site
370438007623	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
370438007624	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
370438007625	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
370438007626	DNA binding site [nucleotide binding]
370438007627	active site
370438007628	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
370438007629	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
370438007630	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
370438007631	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
370438007632	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
370438007633	ring oligomerisation interface [polypeptide binding]; other site
370438007634	ATP/Mg binding site [chemical binding]; other site
370438007635	stacking interactions; other site
370438007636	hinge regions; other site
370438007637	Transposase; Region: DEDD_Tnp_IS110; pfam01548
370438007638	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
370438007639	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
370438007640	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
370438007641	oligomerisation interface [polypeptide binding]; other site
370438007642	mobile loop; other site
370438007643	roof hairpin; other site
370438007644	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
370438007645	MPT binding site; other site
370438007646	trimer interface [polypeptide binding]; other site
370438007647	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
370438007648	trimer interface [polypeptide binding]; other site
370438007649	dimer interface [polypeptide binding]; other site
370438007650	putative active site [active]
370438007651	formate dehydrogenase accessory protein; Reviewed; Region: PRK00724
370438007652	S-layer homology domain; Region: SLH; pfam00395
370438007653	S-layer homology domain; Region: SLH; pfam00395
370438007654	cyclase homology domain; Region: CHD; cd07302
370438007655	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
370438007656	dimer interface [polypeptide binding]; other site
370438007657	CHASE2 domain; Region: CHASE2; pfam05226
370438007658	cyclase homology domain; Region: CHD; cd07302
370438007659	metal binding site [ion binding]; metal-binding site
370438007660	Protein of unknown function (DUF3307); Region: DUF3307; pfam11750
370438007661	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
370438007662	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
370438007663	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
370438007664	putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498
370438007665	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
370438007666	dimer interface [polypeptide binding]; other site
370438007667	putative functional site; other site
370438007668	putative MPT binding site; other site
370438007669	PBP superfamily domain; Region: PBP_like; pfam12727
370438007670	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
370438007671	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
370438007672	dimer interface [polypeptide binding]; other site
370438007673	putative functional site; other site
370438007674	putative MPT binding site; other site
370438007675	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
370438007676	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
370438007677	ATP binding site [chemical binding]; other site
370438007678	substrate interface [chemical binding]; other site
370438007679	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
370438007680	Walker A motif; other site
370438007681	MOSC domain; Region: MOSC; pfam03473
370438007682	molybdenum cofactor biosynthesis protein A, bacterial; Region: moaA; TIGR02666
370438007683	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370438007684	FeS/SAM binding site; other site
370438007685	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
370438007686	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
370438007687	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
370438007688	ThiS family; Region: ThiS; pfam02597
370438007689	charged pocket; other site
370438007690	hydrophobic patch; other site
370438007691	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
370438007692	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_I; cd01990
370438007693	Ligand Binding Site [chemical binding]; other site
370438007694	hypothetical protein; Provisional; Region: PRK04194
370438007695	NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691
370438007696	AIR carboxylase; Region: AIRC; smart01001
370438007697	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
370438007698	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370438007699	NAD(P) binding site [chemical binding]; other site
370438007700	active site
370438007701	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
370438007702	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
370438007703	Walker A motif; other site
370438007704	Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768
370438007705	4Fe-4S binding domain; Region: Fer4; cl02805
370438007706	Uncharacterized Fe-S center protein [General function prediction only]; Region: COG2768
370438007707	Uncharacterized conserved protein [Function unknown]; Region: COG2006
370438007708	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
370438007709	DDE superfamily endonuclease; Region: DDE_5; cl17874
370438007710	Response regulator receiver domain; Region: Response_reg; pfam00072
370438007711	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370438007712	active site
370438007713	phosphorylation site [posttranslational modification]
370438007714	intermolecular recognition site; other site
370438007715	dimerization interface [polypeptide binding]; other site
370438007716	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
370438007717	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438007718	Walker A motif; other site
370438007719	ATP binding site [chemical binding]; other site
370438007720	Walker B motif; other site
370438007721	arginine finger; other site
370438007722	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
370438007723	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
370438007724	GAF domain; Region: GAF; pfam01590
370438007725	PAS domain; Region: PAS_9; pfam13426
370438007726	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
370438007727	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
370438007728	dimer interface [polypeptide binding]; other site
370438007729	phosphorylation site [posttranslational modification]
370438007730	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
370438007731	ATP binding site [chemical binding]; other site
370438007732	Mg2+ binding site [ion binding]; other site
370438007733	G-X-G motif; other site
370438007734	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH4; cd08188
370438007735	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
370438007736	putative active site [active]
370438007737	metal binding site [ion binding]; metal-binding site
370438007738	Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918
370438007739	putative active site [active]
370438007740	putative metal binding site [ion binding]; other site
370438007741	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
370438007742	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
370438007743	molybdopterin cofactor binding site; other site
370438007744	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
370438007745	molybdopterin cofactor binding site; other site
370438007746	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
370438007747	catalytic loop [active]
370438007748	iron binding site [ion binding]; other site
370438007749	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
370438007750	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
370438007751	4Fe-4S dicluster domain; Region: Fer4_8; pfam13183
370438007752	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
370438007753	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
370438007754	catalytic loop [active]
370438007755	iron binding site [ion binding]; other site
370438007756	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
370438007757	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
370438007758	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
370438007759	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
370438007760	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
370438007761	dimer interface [polypeptide binding]; other site
370438007762	[2Fe-2S] cluster binding site [ion binding]; other site
370438007763	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
370438007764	SLBB domain; Region: SLBB; pfam10531
370438007765	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
370438007766	4Fe-4S binding domain; Region: Fer4; pfam00037
370438007767	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
370438007768	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
370438007769	putative dimer interface [polypeptide binding]; other site
370438007770	[2Fe-2S] cluster binding site [ion binding]; other site
370438007771	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
370438007772	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
370438007773	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
370438007774	ACT domain-containing protein [General function prediction only]; Region: COG4747
370438007775	N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908
370438007776	C-terminal ACT domain of a novel protein composed of just two ACT domains; Region: ACT_Bt0572_2; cd04882
370438007777	Radical SAM superfamily; Region: Radical_SAM; pfam04055
370438007778	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370438007779	FeS/SAM binding site; other site
370438007780	Protein of unknown function (DUF512); Region: DUF512; pfam04459
370438007781	UGMP family protein; Validated; Region: PRK09604
370438007782	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
370438007783	Protein of unknown function (DUF3243); Region: DUF3243; pfam11588
370438007784	Thioesterase domain; Region: Thioesterase; pfam00975
370438007785	Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974
370438007786	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
370438007787	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
370438007788	active site
370438007789	DNA binding site [nucleotide binding]
370438007790	Int/Topo IB signature motif; other site
370438007791	tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224
370438007792	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
370438007793	active site
370438007794	DNA binding site [nucleotide binding]
370438007795	Int/Topo IB signature motif; other site
370438007796	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
370438007797	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
370438007798	NAD-dependent deacetylase; Provisional; Region: PRK00481
370438007799	SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407
370438007800	NAD+ binding site [chemical binding]; other site
370438007801	substrate binding site [chemical binding]; other site
370438007802	Zn binding site [ion binding]; other site
370438007803	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
370438007804	Ligand Binding Site [chemical binding]; other site
370438007805	Restriction endonuclease; Region: Mrr_cat; pfam04471
370438007806	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
370438007807	DNA methylase; Region: N6_N4_Mtase; pfam01555
370438007808	XcyI restriction endonuclease; Region: RE_XcyI; pfam09571
370438007809	DDE superfamily endonuclease; Region: DDE_5; cl17874
370438007810	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
370438007811	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
370438007812	pyridoxal 5'-phosphate binding site [chemical binding]; other site
370438007813	catalytic residue [active]
370438007814	ADP-ribose pyrophosphatase [Nucleotide transport and metabolism]; Region: COG1051
370438007815	nudix motif; other site
370438007816	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
370438007817	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
370438007818	Zn2+ binding site [ion binding]; other site
370438007819	Mg2+ binding site [ion binding]; other site
370438007820	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
370438007821	NlpC/P60 family; Region: NLPC_P60; pfam00877
370438007822	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378
370438007823	active site clefts [active]
370438007824	zinc binding site [ion binding]; other site
370438007825	dimer interface [polypeptide binding]; other site
370438007826	RmuC family; Region: RmuC; pfam02646
370438007827	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
370438007828	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
370438007829	S-adenosylmethionine binding site [chemical binding]; other site
370438007830	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
370438007831	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
370438007832	ligand binding site [chemical binding]; other site
370438007833	flexible hinge region; other site
370438007834	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655
370438007835	Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986
370438007836	YKOF-related Family; Region: Ykof; pfam07615
370438007837	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
370438007838	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
370438007839	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
370438007840	HlyD family secretion protein; Region: HlyD_3; pfam13437
370438007841	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
370438007842	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
370438007843	QacR-like protein, C-terminal region; Region: TetR_C_5; pfam08360
370438007844	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: VicK; COG5002
370438007845	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
370438007846	dimerization interface [polypeptide binding]; other site
370438007847	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
370438007848	putative active site [active]
370438007849	heme pocket [chemical binding]; other site
370438007850	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
370438007851	dimer interface [polypeptide binding]; other site
370438007852	phosphorylation site [posttranslational modification]
370438007853	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
370438007854	ATP binding site [chemical binding]; other site
370438007855	Mg2+ binding site [ion binding]; other site
370438007856	G-X-G motif; other site
370438007857	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
370438007858	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370438007859	active site
370438007860	phosphorylation site [posttranslational modification]
370438007861	intermolecular recognition site; other site
370438007862	dimerization interface [polypeptide binding]; other site
370438007863	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
370438007864	DNA binding site [nucleotide binding]
370438007865	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
370438007866	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
370438007867	active site
370438007868	catalytic tetrad [active]
370438007869	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
370438007870	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
370438007871	Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483
370438007872	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
370438007873	Putative ATP-dependent Lon protease; Region: Lon_2; cl11979
370438007874	ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125
370438007875	ResB-like family; Region: ResB; pfam05140
370438007876	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
370438007877	Protein of unknown function (DUF342); Region: DUF342; pfam03961
370438007878	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
370438007879	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
370438007880	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
370438007881	Zn2+ binding site [ion binding]; other site
370438007882	Mg2+ binding site [ion binding]; other site
370438007883	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
370438007884	putative active site [active]
370438007885	Protein of unknown function DUF45; Region: DUF45; cl00636
370438007886	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
370438007887	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
370438007888	Type III restriction enzyme, res subunit; Region: ResIII; pfam04851
370438007889	ATP binding site [chemical binding]; other site
370438007890	HsdM N-terminal domain; Region: HsdM_N; pfam12161
370438007891	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
370438007892	Transposase; Region: DEDD_Tnp_IS110; pfam01548
370438007893	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
370438007894	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
370438007895	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
370438007896	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
370438007897	DNA binding residues [nucleotide binding]
370438007898	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
370438007899	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
370438007900	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
370438007901	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
370438007902	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
370438007903	The MopB_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. Members...; Region: MopB_Acetylene-hydratase; cd02759
370438007904	putative [Fe4-S4] binding site [ion binding]; other site
370438007905	putative molybdopterin cofactor binding site [chemical binding]; other site
370438007906	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
370438007907	The MopB_CT_Acetylene-hydratase CD contains acetylene hydratase (Ahy) and other related proteins. The acetylene hydratase of Pelobacter acetylenicus is a tungsten iron-sulfur protein involved in the fermentation of acetylene to ethanol and acetate. This...; Region: MopB_CT_Acetylene-hydratase; cd02781
370438007908	putative molybdopterin cofactor binding site; other site
370438007909	Recombinase; Region: Recombinase; pfam07508
370438007910	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
370438007911	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
370438007912	SmpB-tmRNA interface; other site
370438007913	Helix-turn-helix domain; Region: HTH_28; pfam13518
370438007914	Winged helix-turn helix; Region: HTH_29; pfam13551
370438007915	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
370438007916	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
370438007917	Zn2+ binding site [ion binding]; other site
370438007918	Mg2+ binding site [ion binding]; other site
370438007919	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
370438007920	CoenzymeA binding site [chemical binding]; other site
370438007921	subunit interaction site [polypeptide binding]; other site
370438007922	PHB binding site; other site
370438007923	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
370438007924	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
370438007925	Preprotein translocase SecG subunit; Region: SecG; pfam03840
370438007926	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
370438007927	metal binding site [ion binding]; metal-binding site
370438007928	substrate binding pocket [chemical binding]; other site
370438007929	enolase; Provisional; Region: eno; PRK00077
370438007930	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
370438007931	dimer interface [polypeptide binding]; other site
370438007932	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
370438007933	phosphoglyceromutase; Provisional; Region: PRK05434
370438007934	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
370438007935	triosephosphate isomerase; Provisional; Region: PRK14565
370438007936	substrate binding site [chemical binding]; other site
370438007937	dimer interface [polypeptide binding]; other site
370438007938	catalytic triad [active]
370438007939	Phosphoglycerate kinase; Region: PGK; pfam00162
370438007940	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
370438007941	substrate binding site [chemical binding]; other site
370438007942	hinge regions; other site
370438007943	ADP binding site [chemical binding]; other site
370438007944	catalytic site [active]
370438007945	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729
370438007946	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
370438007947	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
370438007948	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
370438007949	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
370438007950	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
370438007951	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
370438007952	Protein of unknown function (DUF1405); Region: DUF1405; pfam07187
370438007953	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
370438007954	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
370438007955	trimer interface [polypeptide binding]; other site
370438007956	active site
370438007957	substrate binding site [chemical binding]; other site
370438007958	CoA binding site [chemical binding]; other site
370438007959	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1481
370438007960	Sporulation Regulator WhiA N terminal; Region: WhiA_N; pfam10298
370438007961	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
370438007962	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
370438007963	phosphate binding site [ion binding]; other site
370438007964	putative substrate binding pocket [chemical binding]; other site
370438007965	dimer interface [polypeptide binding]; other site
370438007966	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
370438007967	AAA domain; Region: AAA_33; pfam13671
370438007968	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
370438007969	Histidinol phosphatase and related hydrolases of the PHP family [Amino acid transport and metabolism / General function prediction only]; Region: HIS2; COG1387
370438007970	active site
370438007971	glucose-6-phosphate isomerase; Provisional; Region: PRK00973
370438007972	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
370438007973	active site
370438007974	dimer interface [polypeptide binding]; other site
370438007975	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
370438007976	dimer interface [polypeptide binding]; other site
370438007977	active site
370438007978	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
370438007979	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
370438007980	ROK family; Region: ROK; pfam00480
370438007981	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
370438007982	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
370438007983	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
370438007984	motif II; other site
370438007985	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
370438007986	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
370438007987	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
370438007988	GIY-YIG motif/motif A; other site
370438007989	active site
370438007990	catalytic site [active]
370438007991	putative DNA binding site [nucleotide binding]; other site
370438007992	metal binding site [ion binding]; metal-binding site
370438007993	UvrB/uvrC motif; Region: UVR; pfam02151
370438007994	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
370438007995	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
370438007996	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
370438007997	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
370438007998	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
370438007999	excinuclease ABC subunit B; Provisional; Region: PRK05298
370438008000	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
370438008001	ATP binding site [chemical binding]; other site
370438008002	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
370438008003	nucleotide binding region [chemical binding]; other site
370438008004	ATP-binding site [chemical binding]; other site
370438008005	Ultra-violet resistance protein B; Region: UvrB; pfam12344
370438008006	UvrB/uvrC motif; Region: UVR; pfam02151
370438008007	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
370438008008	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
370438008009	ligand binding site [chemical binding]; other site
370438008010	Protein of unknown function (DUF2508); Region: DUF2508; pfam10704
370438008011	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
370438008012	Fe-S cluster binding site [ion binding]; other site
370438008013	active site
370438008014	Predicted RNA-binding protein; Region: RNA_bind_2; pfam10133
370438008015	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
370438008016	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
370438008017	C-terminal peptidase (prc); Region: prc; TIGR00225
370438008018	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
370438008019	protein binding site [polypeptide binding]; other site
370438008020	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
370438008021	Catalytic dyad [active]
370438008022	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
370438008023	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
370438008024	Peptidase family M23; Region: Peptidase_M23; pfam01551
370438008025	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
370438008026	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
370438008027	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
370438008028	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
370438008029	Walker A/P-loop; other site
370438008030	ATP binding site [chemical binding]; other site
370438008031	Q-loop/lid; other site
370438008032	ABC transporter signature motif; other site
370438008033	Walker B; other site
370438008034	D-loop; other site
370438008035	H-loop/switch region; other site
370438008036	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
370438008037	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
370438008038	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
370438008039	PYR/PP interface [polypeptide binding]; other site
370438008040	dimer interface [polypeptide binding]; other site
370438008041	TPP binding site [chemical binding]; other site
370438008042	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
370438008043	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
370438008044	transketolase; Reviewed; Region: PRK05899
370438008045	TPP-binding site [chemical binding]; other site
370438008046	dimer interface [polypeptide binding]; other site
370438008047	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
370438008048	Uncharacterized conserved protein [Function unknown]; Region: COG1284
370438008049	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
370438008050	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
370438008051	peptide chain release factor 2; Validated; Region: prfB; PRK00578
370438008052	This domain is found in peptide chain release factors; Region: PCRF; smart00937
370438008053	RF-1 domain; Region: RF-1; pfam00472
370438008054	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
370438008055	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
370438008056	ATP binding site [chemical binding]; other site
370438008057	putative Mg++ binding site [ion binding]; other site
370438008058	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
370438008059	SEC-C motif; Region: SEC-C; pfam02810
370438008060	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
370438008061	30S subunit binding site; other site
370438008062	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
370438008063	DNA-binding site [nucleotide binding]; DNA binding site
370438008064	RNA-binding motif; other site
370438008065	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
370438008066	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
370438008067	GAF domain; Region: GAF_3; pfam13492
370438008068	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
370438008069	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
370438008070	metal binding site [ion binding]; metal-binding site
370438008071	active site
370438008072	I-site; other site
370438008073	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
370438008074	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
370438008075	active site
370438008076	S-adenosylmethionine synthetase; Validated; Region: PRK05250
370438008077	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
370438008078	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
370438008079	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
370438008080	sporulation protein, YlmC/YmxH family; Region: spore_YlmC_YmxH; TIGR02888
370438008081	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
370438008082	MviN-like protein; Region: MVIN; pfam03023
370438008083	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
370438008084	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
370438008085	active site
370438008086	substrate binding site [chemical binding]; other site
370438008087	metal binding site [ion binding]; metal-binding site
370438008088	Predicted membrane protein [Function unknown]; Region: COG2323
370438008089	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
370438008090	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
370438008091	NAD(P) binding site [chemical binding]; other site
370438008092	active site
370438008093	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
370438008094	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
370438008095	active site
370438008096	tetramer interface; other site
370438008097	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
370438008098	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
370438008099	Mg++ binding site [ion binding]; other site
370438008100	putative catalytic motif [active]
370438008101	substrate binding site [chemical binding]; other site
370438008102	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
370438008103	Domain of unknown function (DUF4330); Region: DUF4330; pfam14221
370438008104	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
370438008105	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
370438008106	putative homodimer interface [polypeptide binding]; other site
370438008107	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
370438008108	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
370438008109	O-Antigen ligase; Region: Wzy_C; cl04850
370438008110	Transcriptional regulator [Transcription]; Region: LytR; COG1316
370438008111	polysaccharide pyruvyl transferase CsaB; Region: S_layer_CsaB; TIGR03609
370438008112	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
370438008113	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
370438008114	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
370438008115	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
370438008116	Major Facilitator Superfamily; Region: MFS_1; pfam07690
370438008117	putative substrate translocation pore; other site
370438008118	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
370438008119	HicB family; Region: HicB; pfam05534
370438008120	Predicted nucleic acid-binding protein, contains PIN domain [General function prediction only]; Region: COG2402
370438008121	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
370438008122	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
370438008123	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
370438008124	E3 interaction surface; other site
370438008125	lipoyl attachment site [posttranslational modification]; other site
370438008126	HlyD family secretion protein; Region: HlyD_3; pfam13437
370438008127	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
370438008128	HlyD family secretion protein; Region: HlyD_3; pfam13437
370438008129	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
370438008130	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
370438008131	dimerization interface [polypeptide binding]; other site
370438008132	putative Zn2+ binding site [ion binding]; other site
370438008133	putative DNA binding site [nucleotide binding]; other site
370438008134	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
370438008135	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
370438008136	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
370438008137	Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833
370438008138	Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402
370438008139	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
370438008140	putative active site [active]
370438008141	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
370438008142	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
370438008143	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
370438008144	DNA binding residues [nucleotide binding]
370438008145	mycothiol system anti-sigma-R factor; Region: antisig_RsrA; cl15806
370438008146	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
370438008147	PIN domain; Region: PIN; pfam01850
370438008148	putative active site [active]
370438008149	S-layer homology domain; Region: SLH; pfam00395
370438008150	Peptidase S8 family domain in Kp43 proteases; Region: Peptidases_S8_Kp43_protease; cd04842
370438008151	active site
370438008152	catalytic triad [active]
370438008153	rod shape-determining protein Mbl; Provisional; Region: PRK13928
370438008154	MreB and similar proteins; Region: MreB_like; cd10225
370438008155	nucleotide binding site [chemical binding]; other site
370438008156	Mg binding site [ion binding]; other site
370438008157	putative protofilament interaction site [polypeptide binding]; other site
370438008158	RodZ interaction site [polypeptide binding]; other site
370438008159	Stage III sporulation protein D; Region: SpoIIID; pfam12116
370438008160	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
370438008161	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
370438008162	HlyD family secretion protein; Region: HlyD_3; pfam13437
370438008163	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
370438008164	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
370438008165	Walker A/P-loop; other site
370438008166	ATP binding site [chemical binding]; other site
370438008167	Q-loop/lid; other site
370438008168	ABC transporter signature motif; other site
370438008169	Walker B; other site
370438008170	D-loop; other site
370438008171	H-loop/switch region; other site
370438008172	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
370438008173	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
370438008174	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
370438008175	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
370438008176	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
370438008177	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
370438008178	S-layer homology domain; Region: SLH; pfam00395
370438008179	S-layer homology domain; Region: SLH; pfam00395
370438008180	S-layer homology domain; Region: SLH; pfam00395
370438008181	FecR protein; Region: FecR; pfam04773
370438008182	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
370438008183	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
370438008184	Leucine rich repeat; Region: LRR_8; pfam13855
370438008185	Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799
370438008186	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
370438008187	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
370438008188	ligand binding site [chemical binding]; other site
370438008189	flexible hinge region; other site
370438008190	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
370438008191	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438008192	Walker A motif; other site
370438008193	ATP binding site [chemical binding]; other site
370438008194	Walker B motif; other site
370438008195	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
370438008196	PIN domains of VapC and Smg6 ribonucleases, ribosome assembly factor NOB1, Archaeoglobus fulgidus AF0591 protein and homologs; Region: PIN_VapC-Smg6-like; cd09855
370438008197	putative active site [active]
370438008198	Stage II sporulation protein; Region: SpoIID; pfam08486
370438008199	SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669
370438008200	Protein of unknown function (DUF1779); Region: DUF1779; pfam08680
370438008201	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13446
370438008202	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
370438008203	gamma subunit interface [polypeptide binding]; other site
370438008204	LBP interface [polypeptide binding]; other site
370438008205	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
370438008206	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
370438008207	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
370438008208	alpha subunit interaction interface [polypeptide binding]; other site
370438008209	Walker A motif; other site
370438008210	ATP binding site [chemical binding]; other site
370438008211	Walker B motif; other site
370438008212	inhibitor binding site; inhibition site
370438008213	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
370438008214	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
370438008215	core domain interface [polypeptide binding]; other site
370438008216	delta subunit interface [polypeptide binding]; other site
370438008217	epsilon subunit interface [polypeptide binding]; other site
370438008218	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
370438008219	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
370438008220	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
370438008221	beta subunit interaction interface [polypeptide binding]; other site
370438008222	Walker A motif; other site
370438008223	ATP binding site [chemical binding]; other site
370438008224	Walker B motif; other site
370438008225	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
370438008226	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13429
370438008227	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
370438008228	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
370438008229	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
370438008230	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
370438008231	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
370438008232	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
370438008233	ATP synthase I chain; Region: ATP_synt_I; cl09170
370438008234	Putative F0F1-ATPase subunit (ATPase_gene1); Region: ATPase_gene1; pfam09527
370438008235	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
370438008236	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
370438008237	active site
370438008238	homodimer interface [polypeptide binding]; other site
370438008239	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in uncharacterized protein from Archaeoglobus fulgidus (Af0060) and its bacterial homologs; Region: NTP-PPase_Af0060_like; cd11533
370438008240	homodimer interface [polypeptide binding]; other site
370438008241	metal binding site [ion binding]; metal-binding site
370438008242	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
370438008243	catalytic motif [active]
370438008244	Zn binding site [ion binding]; other site
370438008245	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
370438008246	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
370438008247	dimer interface [polypeptide binding]; other site
370438008248	active site
370438008249	glycine-pyridoxal phosphate binding site [chemical binding]; other site
370438008250	folate binding site [chemical binding]; other site
370438008251	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
370438008252	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
370438008253	Low molecular weight phosphatase family; Region: LMWPc; cd00115
370438008254	active site
370438008255	Predicted membrane protein [Function unknown]; Region: COG1971
370438008256	Domain of unknown function DUF; Region: DUF204; pfam02659
370438008257	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
370438008258	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
370438008259	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
370438008260	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
370438008261	S-adenosylmethionine binding site [chemical binding]; other site
370438008262	peptide chain release factor 1; Validated; Region: prfA; PRK00591
370438008263	This domain is found in peptide chain release factors; Region: PCRF; smart00937
370438008264	RF-1 domain; Region: RF-1; pfam00472
370438008265	Protein of unknown function (DUF1385); Region: DUF1385; pfam07136
370438008266	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
370438008267	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370438008268	Radical SAM superfamily; Region: Radical_SAM; pfam04055
370438008269	FeS/SAM binding site; other site
370438008270	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
370438008271	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
370438008272	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
370438008273	Peptidase family M23; Region: Peptidase_M23; pfam01551
370438008274	transcription termination factor Rho; Provisional; Region: rho; PRK09376
370438008275	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
370438008276	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
370438008277	RNA binding site [nucleotide binding]; other site
370438008278	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
370438008279	multimer interface [polypeptide binding]; other site
370438008280	Walker A motif; other site
370438008281	ATP binding site [chemical binding]; other site
370438008282	Walker B motif; other site
370438008283	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
370438008284	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
370438008285	active site
370438008286	intersubunit interactions; other site
370438008287	catalytic residue [active]
370438008288	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
370438008289	intersubunit interface [polypeptide binding]; other site
370438008290	active site
370438008291	zinc binding site [ion binding]; other site
370438008292	Na+ binding site [ion binding]; other site
370438008293	Response regulator receiver domain; Region: Response_reg; pfam00072
370438008294	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
370438008295	active site
370438008296	phosphorylation site [posttranslational modification]
370438008297	intermolecular recognition site; other site
370438008298	dimerization interface [polypeptide binding]; other site
370438008299	Yip1 domain; Region: Yip1; pfam04893
370438008300	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
370438008301	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
370438008302	tandem repeat interface [polypeptide binding]; other site
370438008303	oligomer interface [polypeptide binding]; other site
370438008304	active site residues [active]
370438008305	CTP synthetase; Validated; Region: pyrG; PRK05380
370438008306	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
370438008307	Catalytic site [active]
370438008308	active site
370438008309	UTP binding site [chemical binding]; other site
370438008310	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
370438008311	active site
370438008312	putative oxyanion hole; other site
370438008313	catalytic triad [active]
370438008314	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
370438008315	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
370438008316	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
370438008317	active site
370438008318	HIGH motif; other site
370438008319	KMSK motif region; other site
370438008320	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
370438008321	tRNA binding surface [nucleotide binding]; other site
370438008322	anticodon binding site; other site
370438008323	pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029
370438008324	indolepyruvate oxidoreductase subunit beta; Reviewed; Region: PRK06853
370438008325	indolepyruvate ferredoxin oxidoreductase, alpha subunit; Region: IOR_alpha; TIGR03336
370438008326	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
370438008327	dimer interface [polypeptide binding]; other site
370438008328	PYR/PP interface [polypeptide binding]; other site
370438008329	TPP binding site [chemical binding]; other site
370438008330	substrate binding site [chemical binding]; other site
370438008331	Thiamine pyrophosphate (TPP) family, IOR-alpha subfamily, TPP-binding module; composed of proteins similar to indolepyruvate ferredoxin oxidoreductase (IOR) alpha subunit. IOR catalyzes the oxidative decarboxylation of arylpyruvates, such as...; Region: TPP_IOR_alpha; cd02008
370438008332	TPP-binding site; other site
370438008333	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
370438008334	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
370438008335	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
370438008336	acyl-activating enzyme (AAE) consensus motif; other site
370438008337	AMP binding site [chemical binding]; other site
370438008338	active site
370438008339	CoA binding site [chemical binding]; other site
370438008340	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
370438008341	Na binding site [ion binding]; other site
370438008342	hypothetical protein; Validated; Region: PRK07682
370438008343	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
370438008344	pyridoxal 5'-phosphate binding site [chemical binding]; other site
370438008345	homodimer interface [polypeptide binding]; other site
370438008346	catalytic residue [active]
370438008347	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
370438008348	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
370438008349	AsnC family; Region: AsnC_trans_reg; pfam01037
370438008350	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
370438008351	Na binding site [ion binding]; other site
370438008352	germination protein YpeB; Region: spore_YpeB; TIGR02889
370438008353	spore cortex-lytic enzyme; Region: spore_SleB; TIGR02869
370438008354	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
370438008355	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
370438008356	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
370438008357	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
370438008358	dimer interface [polypeptide binding]; other site
370438008359	putative CheW interface [polypeptide binding]; other site
370438008360	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
370438008361	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
370438008362	dimer interface [polypeptide binding]; other site
370438008363	putative CheW interface [polypeptide binding]; other site
370438008364	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
370438008365	DsrC like protein; Region: DsrC; pfam04358
370438008366	Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590
370438008367	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
370438008368	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
370438008369	hinge; other site
370438008370	active site
370438008371	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
370438008372	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
370438008373	binding surface
370438008374	Tetratricopeptide repeat; Region: TPR_16; pfam13432
370438008375	TPR motif; other site
370438008376	Tetratricopeptide repeat; Region: TPR_16; pfam13432
370438008377	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
370438008378	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
370438008379	G5 domain; Region: G5; pfam07501
370438008380	Peptidase family M23; Region: Peptidase_M23; pfam01551
370438008381	SCIFF radical SAM maturase; Region: rSAM_six_Cys; TIGR03974
370438008382	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
370438008383	FeS/SAM binding site; other site
370438008384	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
370438008385	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
370438008386	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
370438008387	active site
370438008388	HIGH motif; other site
370438008389	nucleotide binding site [chemical binding]; other site
370438008390	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
370438008391	KMSKS motif; other site
370438008392	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
370438008393	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
370438008394	Zn2+ binding site [ion binding]; other site
370438008395	Mg2+ binding site [ion binding]; other site
370438008396	PAS domain S-box; Region: sensory_box; TIGR00229
370438008397	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
370438008398	putative active site [active]
370438008399	heme pocket [chemical binding]; other site
370438008400	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
370438008401	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
370438008402	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
370438008403	GAF domain; Region: GAF; pfam01590
370438008404	succinate dehydrogenase/fumarate reductase iron-sulfur subunit; Provisional; Region: PRK06259
370438008405	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
370438008406	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
370438008407	Helix-turn-helix domain; Region: HTH_17; cl17695
370438008408	CHC2 zinc finger; Region: zf-CHC2; cl17510
370438008409	TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029
370438008410	active site
370438008411	metal binding site [ion binding]; metal-binding site
370438008412	interdomain interaction site; other site
370438008413	AAA domain; Region: AAA_25; pfam13481
370438008414	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
370438008415	Walker A motif; other site
370438008416	ATP binding site [chemical binding]; other site
370438008417	Walker B motif; other site
370438008418	chromosome segregation protein; Provisional; Region: PRK03918
370438008419	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
370438008420	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
370438008421	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
370438008422	GDP-binding site [chemical binding]; other site
370438008423	ACT binding site; other site
370438008424	IMP binding site; other site
370438008425	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
370438008426	L-aspartate oxidase; Provisional; Region: PRK06175
370438008427	replicative DNA helicase; Region: DnaB; TIGR00665
370438008428	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
370438008429	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
370438008430	Walker A motif; other site
370438008431	ATP binding site [chemical binding]; other site
370438008432	Walker B motif; other site
370438008433	DNA binding loops [nucleotide binding]
370438008434	ATP-dependent protease, Lon family; Region: spore_lon_C; TIGR02903
370438008435	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438008436	Walker A motif; other site
370438008437	ATP binding site [chemical binding]; other site
370438008438	Walker B motif; other site
370438008439	arginine finger; other site
370438008440	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
370438008441	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
370438008442	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
370438008443	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
370438008444	Predicted membrane protein (DUF2232); Region: DUF2232; pfam09991
370438008445	MazG-like family; Region: MazG-like; pfam12643
370438008446	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
370438008447	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
370438008448	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
370438008449	dimer interface [polypeptide binding]; other site
370438008450	ssDNA binding site [nucleotide binding]; other site
370438008451	tetramer (dimer of dimers) interface [polypeptide binding]; other site
370438008452	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
370438008453	benzoate transport; Region: 2A0115; TIGR00895
370438008454	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
370438008455	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
370438008456	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
370438008457	classical (c) SDRs; Region: SDR_c; cd05233
370438008458	NAD(P) binding site [chemical binding]; other site
370438008459	active site
370438008460	Putative cyclase; Region: Cyclase; pfam04199
370438008461	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
370438008462	5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193
370438008463	putative active site [active]
370438008464	metal binding site [ion binding]; metal-binding site
370438008465	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
370438008466	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
370438008467	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
370438008468	ThiS family; Region: ThiS; pfam02597
370438008469	charged pocket; other site
370438008470	hydrophobic patch; other site
370438008471	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
370438008472	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
370438008473	Malic enzyme, N-terminal domain; Region: malic; pfam00390
370438008474	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
370438008475	putative NAD(P) binding site [chemical binding]; other site
370438008476	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
370438008477	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
370438008478	putative active site [active]
370438008479	heme pocket [chemical binding]; other site
370438008480	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
370438008481	Walker A motif; other site
370438008482	ATP binding site [chemical binding]; other site
370438008483	Walker B motif; other site
370438008484	arginine finger; other site
370438008485	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
370438008486	Carbohydrate binding domain; Region: CBM_25; smart01066
370438008487	Bacterial protein of unknown function (DUF951); Region: DUF951; pfam06107
370438008488	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
370438008489	Mechanosensitive ion channel; Region: MS_channel; pfam00924
370438008490	M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659
370438008491	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
370438008492	oligomer interface [polypeptide binding]; other site
370438008493	putative active site [active]
370438008494	metal binding site [ion binding]; metal-binding site
370438008495	Transposase IS200 like; Region: Y1_Tnp; pfam01797
370438008496	Colicin V production protein; Region: Colicin_V; pfam02674
370438008497	Colicin V production protein; Region: Colicin_V; pfam02674
370438008498	Uncharacterized membrane protein [Function unknown]; Region: COG3949
370438008499	Protein of unknown function (DUF1256); Region: DUF1256; cl06087
370438008500	Uncharacterized protein family (UPF0180); Region: UPF0180; cl04214
370438008501	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
370438008502	active site
370438008503	Protein of unknown function DUF111; Region: DUF111; pfam01969
370438008504	Protein of unknown function (DUF554); Region: DUF554; pfam04474
370438008505	ParB-like nuclease domain; Region: ParBc; pfam02195
370438008506	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
370438008507	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
370438008508	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
370438008509	P-loop; other site
370438008510	Magnesium ion binding site [ion binding]; other site
370438008511	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
370438008512	Magnesium ion binding site [ion binding]; other site
370438008513	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
370438008514	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
370438008515	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
370438008516	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
370438008517	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
370438008518	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
370438008519	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
370438008520	trmE is a tRNA modification GTPase; Region: trmE; cd04164
370438008521	G1 box; other site
370438008522	GTP/Mg2+ binding site [chemical binding]; other site
370438008523	Switch I region; other site
370438008524	G2 box; other site
370438008525	Switch II region; other site
370438008526	G3 box; other site
370438008527	G4 box; other site
370438008528	G5 box; other site
370438008529	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
370438008530	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
370438008531	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
370438008532	G-X-X-G motif; other site
370438008533	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
370438008534	RxxxH motif; other site
370438008535	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
370438008536	Ribonuclease P; Region: Ribonuclease_P; cl00457