-- dump date   	20140619_233350
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
403833000001	chromosomal replication initiation protein; Provisional; Region: dnaA; PRK14088
403833000002	DnaA N-terminal domain; Region: DnaA_N; pfam11638
403833000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
403833000004	Walker A motif; other site
403833000005	ATP binding site [chemical binding]; other site
403833000006	Walker B motif; other site
403833000007	arginine finger; other site
403833000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
403833000009	DnaA box-binding interface [nucleotide binding]; other site
403833000010	Encapsulating protein for peroxidase; Region: Linocin_M18; pfam04454
403833000011	Uncharacterized conserved protein [Function unknown]; Region: COG3461
403833000012	PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861
403833000013	putative active site [active]
403833000014	Protein of unknown function (DUF2281); Region: DUF2281; pfam10047
403833000015	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
403833000016	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833000017	dimer interface [polypeptide binding]; other site
403833000018	conserved gate region; other site
403833000019	putative PBP binding loops; other site
403833000020	ABC-ATPase subunit interface; other site
403833000021	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833000022	dimer interface [polypeptide binding]; other site
403833000023	conserved gate region; other site
403833000024	putative PBP binding loops; other site
403833000025	ABC-ATPase subunit interface; other site
403833000026	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
403833000027	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
403833000028	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
403833000029	intersubunit interface [polypeptide binding]; other site
403833000030	active site
403833000031	catalytic residue [active]
403833000032	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
403833000033	DNA-binding site [nucleotide binding]; DNA binding site
403833000034	RNA-binding motif; other site
403833000035	elongation factor P; Validated; Region: PRK00529
403833000036	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
403833000037	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
403833000038	RNA binding site [nucleotide binding]; other site
403833000039	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
403833000040	RNA binding site [nucleotide binding]; other site
403833000041	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
403833000042	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
403833000043	Transcriptional regulators [Transcription]; Region: MarR; COG1846
403833000044	MarR family; Region: MarR_2; pfam12802
403833000045	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
403833000046	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137
403833000047	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
403833000048	MarR family; Region: MarR; pfam01047
403833000049	PEGA domain; Region: PEGA; pfam08308
403833000050	PEGA domain; Region: PEGA; pfam08308
403833000051	V-type ATP synthase subunit I; Validated; Region: PRK05771
403833000052	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
403833000053	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
403833000054	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
403833000055	active site
403833000056	nucleophile elbow; other site
403833000057	Patatin-like phospholipase; Region: Patatin; pfam01734
403833000058	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
403833000059	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
403833000060	HEAT repeats; Region: HEAT_2; pfam13646
403833000061	Uncharacterized protein containing a Zn-ribbon (DUF2116); Region: DUF2116; cl01683
403833000062	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
403833000063	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
403833000064	active site
403833000065	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
403833000066	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
403833000067	substrate binding site [chemical binding]; other site
403833000068	ATP binding site [chemical binding]; other site
403833000069	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
403833000070	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
403833000071	folate binding site [chemical binding]; other site
403833000072	NADP+ binding site [chemical binding]; other site
403833000073	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
403833000074	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
403833000075	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833000076	dimer interface [polypeptide binding]; other site
403833000077	conserved gate region; other site
403833000078	putative PBP binding loops; other site
403833000079	ABC-ATPase subunit interface; other site
403833000080	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
403833000081	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833000082	dimer interface [polypeptide binding]; other site
403833000083	conserved gate region; other site
403833000084	putative PBP binding loops; other site
403833000085	ABC-ATPase subunit interface; other site
403833000086	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14316
403833000087	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
403833000088	active site
403833000089	substrate binding site [chemical binding]; other site
403833000090	metal binding site [ion binding]; metal-binding site
403833000091	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
403833000092	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
403833000093	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
403833000094	protein binding site [polypeptide binding]; other site
403833000095	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
403833000096	protein binding site [polypeptide binding]; other site
403833000097	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
403833000098	active site
403833000099	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
403833000100	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
403833000101	transcription termination factor Rho; Provisional; Region: rho; PRK09376
403833000102	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
403833000103	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
403833000104	RNA binding site [nucleotide binding]; other site
403833000105	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
403833000106	Walker A motif; other site
403833000107	ATP binding site [chemical binding]; other site
403833000108	Walker B motif; other site
403833000109	Protein of unknown function (DUF1385); Region: DUF1385; pfam07136
403833000110	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
403833000111	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
403833000112	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
403833000113	intersubunit interface [polypeptide binding]; other site
403833000114	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
403833000115	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
403833000116	ABC-ATPase subunit  interface; other site
403833000117	dimer interface [polypeptide binding]; other site
403833000118	putative PBP binding regions; other site
403833000119	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
403833000120	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
403833000121	Walker A/P-loop; other site
403833000122	ATP binding site [chemical binding]; other site
403833000123	Q-loop/lid; other site
403833000124	ABC transporter signature motif; other site
403833000125	Walker B; other site
403833000126	D-loop; other site
403833000127	H-loop/switch region; other site
403833000128	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
403833000129	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
403833000130	substrate binding site [chemical binding]; other site
403833000131	ATP binding site [chemical binding]; other site
403833000132	Predicted transcriptional regulator [Transcription]; Region: COG1959
403833000133	Transcriptional regulator; Region: Rrf2; pfam02082
403833000134	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
403833000135	2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029
403833000136	2-phosphosulfolactate phosphatase; Provisional; Region: PRK14100
403833000137	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
403833000138	catalytic core [active]
403833000139	GMP synthase; Reviewed; Region: guaA; PRK00074
403833000140	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
403833000141	AMP/PPi binding site [chemical binding]; other site
403833000142	candidate oxyanion hole; other site
403833000143	catalytic triad [active]
403833000144	potential glutamine specificity residues [chemical binding]; other site
403833000145	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
403833000146	ATP Binding subdomain [chemical binding]; other site
403833000147	Ligand Binding sites [chemical binding]; other site
403833000148	Dimerization subdomain; other site
403833000149	hypothetical protein; Provisional; Region: PRK13670
403833000150	HIGH Nucleotidyl Transferase; Region: HIGH_NTase1; cl17673
403833000151	stationary phase survival protein SurE; Provisional; Region: PRK13935
403833000152	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
403833000153	active site
403833000154	catalytic residues [active]
403833000155	metal binding site [ion binding]; metal-binding site
403833000156	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
403833000157	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
403833000158	putative active site [active]
403833000159	substrate binding site [chemical binding]; other site
403833000160	putative cosubstrate binding site; other site
403833000161	catalytic site [active]
403833000162	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
403833000163	substrate binding site [chemical binding]; other site
403833000164	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
403833000165	active site
403833000166	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
403833000167	trimer interface [polypeptide binding]; other site
403833000168	putative Zn binding site [ion binding]; other site
403833000169	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
403833000170	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
403833000171	active site
403833000172	motif I; other site
403833000173	motif II; other site
403833000174	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
403833000175	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
403833000176	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
403833000177	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
403833000178	hinge; other site
403833000179	active site
403833000180	S-layer homology domain; Region: SLH; pfam00395
403833000181	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
403833000182	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
403833000183	active site
403833000184	HIGH motif; other site
403833000185	dimer interface [polypeptide binding]; other site
403833000186	KMSKS motif; other site
403833000187	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
403833000188	RNA binding surface [nucleotide binding]; other site
403833000189	Preprotein translocase SecG subunit; Region: SecG; pfam03840
403833000190	Transcriptional regulators [Transcription]; Region: PurR; COG1609
403833000191	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
403833000192	DNA binding site [nucleotide binding]
403833000193	domain linker motif; other site
403833000194	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
403833000195	ligand binding site [chemical binding]; other site
403833000196	dimerization interface [polypeptide binding]; other site
403833000197	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
403833000198	carbohydrate binding site [chemical binding]; other site
403833000199	pullulanase, type I; Region: pulA_typeI; TIGR02104
403833000200	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
403833000201	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
403833000202	Ca binding site [ion binding]; other site
403833000203	active site
403833000204	catalytic site [active]
403833000205	Domain of unknown function (DUF3372); Region: DUF3372; pfam11852
403833000206	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; cl00779
403833000207	FMN-binding domain; Region: FMN_bind; cl01081
403833000208	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
403833000209	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
403833000210	Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464
403833000211	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
403833000212	catalytic loop [active]
403833000213	iron binding site [ion binding]; other site
403833000214	Phenol 2-monooxygenase (phenol hydroxylase) is a flavoprotein monooxygenase, able to use molecular oxygen as a substrate in the microbial degredation of phenol. This protein is encoded by a single gene and uses a tightly bound FAD cofactor in the NAD(P)H...; Region: phenol_2-monooxygenase_like; cd06211
403833000215	FAD binding pocket [chemical binding]; other site
403833000216	FAD binding motif [chemical binding]; other site
403833000217	phosphate binding motif [ion binding]; other site
403833000218	beta-alpha-beta structure motif; other site
403833000219	NAD binding pocket [chemical binding]; other site
403833000220	ornithine carbamoyltransferase; Validated; Region: PRK02102
403833000221	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
403833000222	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
403833000223	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
403833000224	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
403833000225	putative substrate binding site [chemical binding]; other site
403833000226	nucleotide binding site [chemical binding]; other site
403833000227	nucleotide binding site [chemical binding]; other site
403833000228	homodimer interface [polypeptide binding]; other site
403833000229	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
403833000230	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
403833000231	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
403833000232	putative active site [active]
403833000233	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
403833000234	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
403833000235	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
403833000236	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833000237	dimer interface [polypeptide binding]; other site
403833000238	conserved gate region; other site
403833000239	putative PBP binding loops; other site
403833000240	ABC-ATPase subunit interface; other site
403833000241	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
403833000242	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833000243	dimer interface [polypeptide binding]; other site
403833000244	conserved gate region; other site
403833000245	putative PBP binding loops; other site
403833000246	ABC-ATPase subunit interface; other site
403833000247	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
403833000248	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
403833000249	Macro domain, Af1521- and BAL-like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Af1521_BAL_like; cd02907
403833000250	ADP-ribose binding site [chemical binding]; other site
403833000251	putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304
403833000252	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
403833000253	DNA polymerase I; Provisional; Region: PRK05755
403833000254	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
403833000255	active site
403833000256	metal binding site 1 [ion binding]; metal-binding site
403833000257	putative 5' ssDNA interaction site; other site
403833000258	metal binding site 3; metal-binding site
403833000259	metal binding site 2 [ion binding]; metal-binding site
403833000260	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
403833000261	putative DNA binding site [nucleotide binding]; other site
403833000262	putative metal binding site [ion binding]; other site
403833000263	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
403833000264	active site
403833000265	catalytic site [active]
403833000266	substrate binding site [chemical binding]; other site
403833000267	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
403833000268	active site
403833000269	DNA binding site [nucleotide binding]
403833000270	catalytic site [active]
403833000271	ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125
403833000272	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
403833000273	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
403833000274	FeS/SAM binding site; other site
403833000275	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
403833000276	2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258
403833000277	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
403833000278	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
403833000279	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
403833000280	hexamer interface [polypeptide binding]; other site
403833000281	RecA/RadA recombinase [DNA replication, recombination, and repair]; Region: RecA; COG0468
403833000282	Walker A motif; other site
403833000283	ATP binding site [chemical binding]; other site
403833000284	Walker B motif; other site
403833000285	RecX family; Region: RecX; pfam02631
403833000286	Domain of unknown function (DUF3552); Region: DUF3552; pfam12072
403833000287	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
403833000288	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
403833000289	Zn2+ binding site [ion binding]; other site
403833000290	Mg2+ binding site [ion binding]; other site
403833000291	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419
403833000292	ATP-binding cassette domain of sbcCD; Region: ABC_sbcCD; cd03279
403833000293	Walker A/P-loop; other site
403833000294	ATP binding site [chemical binding]; other site
403833000295	Q-loop/lid; other site
403833000296	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
403833000297	ABC transporter signature motif; other site
403833000298	Walker B; other site
403833000299	D-loop; other site
403833000300	H-loop/switch region; other site
403833000301	DNA repair exonuclease [DNA replication, recombination, and repair]; Region: SbcD; COG0420
403833000302	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
403833000303	active site
403833000304	metal binding site [ion binding]; metal-binding site
403833000305	DNA binding site [nucleotide binding]
403833000306	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
403833000307	Uncharacterized conserved protein [Function unknown]; Region: COG1633
403833000308	Uncharacterized family of ferritin-like proteins found in archaea and bacteria; Region: Ferritin_like_AB; cd01045
403833000309	diiron binding motif [ion binding]; other site
403833000310	Uncharacterized protein family (UPF0259); Region: UPF0259; cl11642
403833000311	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
403833000312	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
403833000313	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
403833000314	S-adenosylmethionine binding site [chemical binding]; other site
403833000315	Adenosine specific kinase; Region: Adenosine_kin; pfam04008
403833000316	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
403833000317	substrate binding site [chemical binding]; other site
403833000318	hypothetical protein; Provisional; Region: PRK04164
403833000319	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
403833000320	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
403833000321	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
403833000322	active site
403833000323	phosphorylation site [posttranslational modification]
403833000324	intermolecular recognition site; other site
403833000325	dimerization interface [polypeptide binding]; other site
403833000326	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
403833000327	DNA binding site [nucleotide binding]
403833000328	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
403833000329	HAMP domain; Region: HAMP; pfam00672
403833000330	dimerization interface [polypeptide binding]; other site
403833000331	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
403833000332	dimer interface [polypeptide binding]; other site
403833000333	phosphorylation site [posttranslational modification]
403833000334	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
403833000335	ATP binding site [chemical binding]; other site
403833000336	Mg2+ binding site [ion binding]; other site
403833000337	G-X-G motif; other site
403833000338	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
403833000339	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
403833000340	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
403833000341	catalytic residue [active]
403833000342	hypothetical protein; Provisional; Region: PRK11820
403833000343	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
403833000344	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
403833000345	hypothetical protein; Provisional; Region: PRK04323
403833000346	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
403833000347	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
403833000348	catalytic site [active]
403833000349	G-X2-G-X-G-K; other site
403833000350	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
403833000351	seryl-tRNA synthetase; Provisional; Region: PRK05431
403833000352	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
403833000353	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
403833000354	dimer interface [polypeptide binding]; other site
403833000355	active site
403833000356	motif 1; other site
403833000357	motif 2; other site
403833000358	motif 3; other site
403833000359	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
403833000360	RNA methyltransferase, RsmE family; Region: TIGR00046
403833000361	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
403833000362	Mechanosensitive ion channel; Region: MS_channel; pfam00924
403833000363	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
403833000364	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
403833000365	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
403833000366	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK12634
403833000367	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
403833000368	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
403833000369	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
403833000370	Flagellar protein (FlbD); Region: FlbD; pfam06289
403833000371	flagellar motor protein MotP; Reviewed; Region: PRK06743
403833000372	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
403833000373	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
403833000374	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
403833000375	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
403833000376	ligand binding site [chemical binding]; other site
403833000377	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
403833000378	Flagellar motor switch protein [Cell motility and secretion]; Region: FliM; COG1868
403833000379	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
403833000380	flagellar motor switch protein; Validated; Region: PRK08119
403833000381	CheC-like family; Region: CheC; pfam04509
403833000382	CheC-like family; Region: CheC; pfam04509
403833000383	flagellar motor switch protein FliN; Region: fliN; TIGR02480
403833000384	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
403833000385	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
403833000386	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
403833000387	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
403833000388	Walker A/P-loop; other site
403833000389	ATP binding site [chemical binding]; other site
403833000390	Q-loop/lid; other site
403833000391	ABC transporter signature motif; other site
403833000392	Walker B; other site
403833000393	D-loop; other site
403833000394	H-loop/switch region; other site
403833000395	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
403833000396	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
403833000397	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
403833000398	Walker A/P-loop; other site
403833000399	ATP binding site [chemical binding]; other site
403833000400	Q-loop/lid; other site
403833000401	ABC transporter signature motif; other site
403833000402	Walker B; other site
403833000403	D-loop; other site
403833000404	H-loop/switch region; other site
403833000405	Esterase/lipase [General function prediction only]; Region: COG1647
403833000406	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
403833000407	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
403833000408	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
403833000409	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
403833000410	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
403833000411	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
403833000412	Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282
403833000413	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
403833000414	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
403833000415	active site
403833000416	homodimer interface [polypeptide binding]; other site
403833000417	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
403833000418	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
403833000419	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
403833000420	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
403833000421	NAD binding site [chemical binding]; other site
403833000422	sugar binding site [chemical binding]; other site
403833000423	divalent metal binding site [ion binding]; other site
403833000424	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
403833000425	dimer interface [polypeptide binding]; other site
403833000426	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
403833000427	intersubunit interface [polypeptide binding]; other site
403833000428	active site
403833000429	Zn2+ binding site [ion binding]; other site
403833000430	Domain of unknown function (DUF2088); Region: DUF2088; cl15406
403833000431	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
403833000432	Ligand binding site [chemical binding]; other site
403833000433	Electron transfer flavoprotein domain; Region: ETF; pfam01012
403833000434	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
403833000435	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
403833000436	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
403833000437	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
403833000438	FAD binding domain; Region: FAD_binding_4; pfam01565
403833000439	L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771
403833000440	N- and C-terminal domain interface [polypeptide binding]; other site
403833000441	rhamnulokinase; Region: rhamnulo_kin; TIGR02627
403833000442	active site
403833000443	putative catalytic site [active]
403833000444	metal binding site [ion binding]; metal-binding site
403833000445	ATP binding site [chemical binding]; other site
403833000446	carbohydrate binding site [chemical binding]; other site
403833000447	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
403833000448	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
403833000449	catalytic triad [active]
403833000450	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
403833000451	Ferritin-like domain; Region: Ferritin; pfam00210
403833000452	ferroxidase diiron center [ion binding]; other site
403833000453	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
403833000454	dimerization interface [polypeptide binding]; other site
403833000455	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
403833000456	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
403833000457	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
403833000458	dimer interface [polypeptide binding]; other site
403833000459	putative CheW interface [polypeptide binding]; other site
403833000460	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
403833000461	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
403833000462	cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04135
403833000463	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
403833000464	Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554
403833000465	Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636
403833000466	Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632
403833000467	Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633
403833000468	beta-phosphoglucomutase; Region: bPGM; TIGR01990
403833000469	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
403833000470	motif II; other site
403833000471	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
403833000472	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833000473	dimer interface [polypeptide binding]; other site
403833000474	conserved gate region; other site
403833000475	putative PBP binding loops; other site
403833000476	ABC-ATPase subunit interface; other site
403833000477	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
403833000478	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833000479	dimer interface [polypeptide binding]; other site
403833000480	conserved gate region; other site
403833000481	putative PBP binding loops; other site
403833000482	ABC-ATPase subunit interface; other site
403833000483	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
403833000484	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
403833000485	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
403833000486	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
403833000487	motif II; other site
403833000488	Predicted hydrolase of the HAD superfamily [General function prediction only]; Region: COG2179
403833000489	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
403833000490	active site
403833000491	motif I; other site
403833000492	motif II; other site
403833000493	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
403833000494	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
403833000495	putative active site [active]
403833000496	PhoH-like protein; Region: PhoH; pfam02562
403833000497	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
403833000498	active site
403833000499	catalytic site [active]
403833000500	substrate binding site [chemical binding]; other site
403833000501	Stage V sporulation protein S (SpoVS); Region: SpoVS; pfam04232
403833000502	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
403833000503	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
403833000504	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
403833000505	AAA domain; Region: AAA_18; pfam13238
403833000506	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
403833000507	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
403833000508	phosphate binding site [ion binding]; other site
403833000509	putative substrate binding pocket [chemical binding]; other site
403833000510	dimer interface [polypeptide binding]; other site
403833000511	Sporulation Regulator WhiA C terminal domain; Region: HTH_WhiA; pfam02650
403833000512	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
403833000513	ATP cone domain; Region: ATP-cone; pfam03477
403833000514	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
403833000515	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
403833000516	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
403833000517	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
403833000518	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
403833000519	dimer interface [polypeptide binding]; other site
403833000520	putative anticodon binding site; other site
403833000521	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
403833000522	motif 1; other site
403833000523	active site
403833000524	motif 2; other site
403833000525	motif 3; other site
403833000526	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK04181
403833000527	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
403833000528	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
403833000529	Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212
403833000530	tetramer interface [polypeptide binding]; other site
403833000531	pyridoxal 5'-phosphate binding site [chemical binding]; other site
403833000532	catalytic residue [active]
403833000533	EamA-like transporter family; Region: EamA; pfam00892
403833000534	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
403833000535	EamA-like transporter family; Region: EamA; pfam00892
403833000536	Protein of unknown function (DUF458); Region: DUF458; pfam04308
403833000537	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
403833000538	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
403833000539	DNA-binding site [nucleotide binding]; DNA binding site
403833000540	UTRA domain; Region: UTRA; pfam07702
403833000541	Chromate transporter; Region: Chromate_transp; pfam02417
403833000542	Chromate transporter; Region: Chromate_transp; pfam02417
403833000543	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
403833000544	putative active site pocket [active]
403833000545	cleavage site
403833000546	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
403833000547	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
403833000548	Type II/IV secretion system protein; Region: T2SE; pfam00437
403833000549	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
403833000550	Walker A motif; other site
403833000551	ATP binding site [chemical binding]; other site
403833000552	Walker B motif; other site
403833000553	cell division protein FtsZ; Region: ftsZ; TIGR00065
403833000554	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
403833000555	nucleotide binding site [chemical binding]; other site
403833000556	SulA interaction site; other site
403833000557	cell division protein FtsA; Region: ftsA; TIGR01174
403833000558	Cell division protein FtsA; Region: FtsA; cl17206
403833000559	Cell division protein FtsA; Region: FtsA; pfam14450
403833000560	DNA gyrase subunit B; Validated; Region: gyrB; PRK05644
403833000561	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
403833000562	ATP binding site [chemical binding]; other site
403833000563	Mg2+ binding site [ion binding]; other site
403833000564	G-X-G motif; other site
403833000565	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
403833000566	anchoring element; other site
403833000567	dimer interface [polypeptide binding]; other site
403833000568	ATP binding site [chemical binding]; other site
403833000569	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
403833000570	active site
403833000571	putative metal-binding site [ion binding]; other site
403833000572	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
403833000573	Protein of unknown function (DUF721); Region: DUF721; pfam05258
403833000574	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
403833000575	PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449
403833000576	homodimer interface [polypeptide binding]; other site
403833000577	substrate-cofactor binding pocket; other site
403833000578	pyridoxal 5'-phosphate binding site [chemical binding]; other site
403833000579	catalytic residue [active]
403833000580	2-methylthioadenine synthetase [Translation, ribosomal structure and biogenesis]; Region: MiaB; COG0621
403833000581	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
403833000582	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
403833000583	FeS/SAM binding site; other site
403833000584	FOG: CBS domain [General function prediction only]; Region: COG0517
403833000585	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
403833000586	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
403833000587	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
403833000588	putative substrate binding site [chemical binding]; other site
403833000589	putative ATP binding site [chemical binding]; other site
403833000590	Molybdenum cofactor biosynthesis enzyme [Coenzyme metabolism]; Region: MoaA; COG2896
403833000591	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
403833000592	FeS/SAM binding site; other site
403833000593	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
403833000594	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
403833000595	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
403833000596	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
403833000597	putative acyl-acceptor binding pocket; other site
403833000598	Bifunctional nuclease; Region: DNase-RNase; pfam02577
403833000599	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
403833000600	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
403833000601	substrate binding pocket [chemical binding]; other site
403833000602	chain length determination region; other site
403833000603	substrate-Mg2+ binding site; other site
403833000604	catalytic residues [active]
403833000605	aspartate-rich region 1; other site
403833000606	active site lid residues [active]
403833000607	aspartate-rich region 2; other site
403833000608	Putative serine esterase (DUF676); Region: DUF676; pfam05057
403833000609	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
403833000610	Tetratricopeptide repeat; Region: TPR_16; pfam13432
403833000611	Conserved hypothetical protein 95; Region: Cons_hypoth95; pfam03602
403833000612	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
403833000613	S-adenosylmethionine binding site [chemical binding]; other site
403833000614	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
403833000615	active site
403833000616	dimer interface [polypeptide binding]; other site
403833000617	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
403833000618	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
403833000619	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
403833000620	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
403833000621	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
403833000622	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
403833000623	generic binding surface II; other site
403833000624	ssDNA binding site; other site
403833000625	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
403833000626	ATP binding site [chemical binding]; other site
403833000627	putative Mg++ binding site [ion binding]; other site
403833000628	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
403833000629	nucleotide binding region [chemical binding]; other site
403833000630	ATP-binding site [chemical binding]; other site
403833000631	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
403833000632	O-Antigen ligase; Region: Wzy_C; pfam04932
403833000633	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
403833000634	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
403833000635	active site
403833000636	metal binding site [ion binding]; metal-binding site
403833000637	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
403833000638	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
403833000639	active site
403833000640	phosphorylation site [posttranslational modification]
403833000641	intermolecular recognition site; other site
403833000642	dimerization interface [polypeptide binding]; other site
403833000643	CheB methylesterase; Region: CheB_methylest; pfam01339
403833000644	Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219
403833000645	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
403833000646	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
403833000647	2-oxoglutarate ferredoxin oxidoreductase subunit beta; Validated; Region: PRK05778
403833000648	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
403833000649	TPP-binding site [chemical binding]; other site
403833000650	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
403833000651	catalytic motif [active]
403833000652	Zn binding site [ion binding]; other site
403833000653	Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635
403833000654	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
403833000655	FeS/SAM binding site; other site
403833000656	HemN C-terminal domain; Region: HemN_C; pfam06969
403833000657	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
403833000658	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
403833000659	GatB domain; Region: GatB_Yqey; smart00845
403833000660	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
403833000661	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
403833000662	Rhomboid family; Region: Rhomboid; pfam01694
403833000663	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
403833000664	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
403833000665	putative tRNA-binding site [nucleotide binding]; other site
403833000666	B3/4 domain; Region: B3_4; pfam03483
403833000667	tRNA synthetase B5 domain; Region: B5; pfam03484
403833000668	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
403833000669	dimer interface [polypeptide binding]; other site
403833000670	motif 1; other site
403833000671	motif 3; other site
403833000672	motif 2; other site
403833000673	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
403833000674	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
403833000675	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
403833000676	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
403833000677	dimer interface [polypeptide binding]; other site
403833000678	motif 1; other site
403833000679	active site
403833000680	motif 2; other site
403833000681	motif 3; other site
403833000682	large T antigen; Provisional; Region: PHA02624
403833000683	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
403833000684	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
403833000685	Walker A/P-loop; other site
403833000686	ATP binding site [chemical binding]; other site
403833000687	Q-loop/lid; other site
403833000688	ABC transporter signature motif; other site
403833000689	Walker B; other site
403833000690	D-loop; other site
403833000691	H-loop/switch region; other site
403833000692	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
403833000693	Predicted transcriptional regulators [Transcription]; Region: COG1695
403833000694	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
403833000695	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
403833000696	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
403833000697	putative catalytic cysteine [active]
403833000698	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
403833000699	pyrroline-5-carboxylate reductase; Region: PLN02688
403833000700	adenylosuccinate lyase; Provisional; Region: PRK07492
403833000701	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
403833000702	tetramer interface [polypeptide binding]; other site
403833000703	active site
403833000704	Adenylosuccinate lyase C-terminus; Region: ADSL_C; pfam10397
403833000705	AAA domain; Region: AAA_32; pfam13654
403833000706	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
403833000707	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
403833000708	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
403833000709	active site
403833000710	Zn binding site [ion binding]; other site
403833000711	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
403833000712	putative active site [active]
403833000713	catalytic triad [active]
403833000714	putative dimer interface [polypeptide binding]; other site
403833000715	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
403833000716	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_6; cd12165
403833000717	putative ligand binding site [chemical binding]; other site
403833000718	NAD binding site [chemical binding]; other site
403833000719	dimer interface [polypeptide binding]; other site
403833000720	putative catalytic site [active]
403833000721	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
403833000722	N- and C-terminal domain interface [polypeptide binding]; other site
403833000723	D-xylulose kinase; Region: XylB; TIGR01312
403833000724	active site
403833000725	MgATP binding site [chemical binding]; other site
403833000726	catalytic site [active]
403833000727	metal binding site [ion binding]; metal-binding site
403833000728	xylulose binding site [chemical binding]; other site
403833000729	homodimer interface [polypeptide binding]; other site
403833000730	MarR family; Region: MarR_2; pfam12802
403833000731	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
403833000732	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
403833000733	nucleotide binding site [chemical binding]; other site
403833000734	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
403833000735	xylose isomerase; Provisional; Region: PRK05474
403833000736	xylose isomerase; Region: xylose_isom_A; TIGR02630
403833000737	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
403833000738	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
403833000739	dimerization interface [polypeptide binding]; other site
403833000740	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
403833000741	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
403833000742	dimer interface [polypeptide binding]; other site
403833000743	putative CheW interface [polypeptide binding]; other site
403833000744	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
403833000745	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
403833000746	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
403833000747	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
403833000748	Carbohydrate binding domain; Region: CBM_4_9; pfam02018
403833000749	Glycosyl hydrolase family 10; Region: Glyco_hydro_10; pfam00331
403833000750	Domon-like ligand-binding domains; Region: DOMON_like; cl14783
403833000751	putative ligand binding site [chemical binding]; other site
403833000752	DOMON-like type 9 carbohydrate binding module of xylanases; Region: CBM9_like_1; cd00005
403833000753	Ca binding site [ion binding]; other site
403833000754	carbohydrate binding site [chemical binding]; other site
403833000755	Putative catalytic NodB homology domain of gellan lyase and similar proteins; Region: CE4_GLA_like_6s; cd10967
403833000756	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
403833000757	putative active site [active]
403833000758	putative metal binding site [ion binding]; other site
403833000759	Right handed beta helix region; Region: Beta_helix; pfam13229
403833000760	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
403833000761	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
403833000762	Walker A/P-loop; other site
403833000763	ATP binding site [chemical binding]; other site
403833000764	Q-loop/lid; other site
403833000765	ABC transporter signature motif; other site
403833000766	Walker B; other site
403833000767	D-loop; other site
403833000768	H-loop/switch region; other site
403833000769	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
403833000770	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
403833000771	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
403833000772	Walker A/P-loop; other site
403833000773	ATP binding site [chemical binding]; other site
403833000774	Q-loop/lid; other site
403833000775	ABC transporter signature motif; other site
403833000776	Walker B; other site
403833000777	D-loop; other site
403833000778	H-loop/switch region; other site
403833000779	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
403833000780	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
403833000781	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833000782	dimer interface [polypeptide binding]; other site
403833000783	conserved gate region; other site
403833000784	putative PBP binding loops; other site
403833000785	ABC-ATPase subunit interface; other site
403833000786	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
403833000787	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833000788	dimer interface [polypeptide binding]; other site
403833000789	conserved gate region; other site
403833000790	putative PBP binding loops; other site
403833000791	ABC-ATPase subunit interface; other site
403833000792	The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509
403833000793	substrate binding site [chemical binding]; other site
403833000794	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
403833000795	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
403833000796	active sites [active]
403833000797	tetramer interface [polypeptide binding]; other site
403833000798	urocanate hydratase; Provisional; Region: PRK05414
403833000799	Glutamate formiminotransferase [Amino acid transport and metabolism]; Region: COG3643
403833000800	Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837
403833000801	Formiminotransferase domain; Region: FTCD; pfam02971
403833000802	imidazolonepropionase; Validated; Region: PRK09356
403833000803	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
403833000804	active site
403833000805	Competence protein; Region: Competence; pfam03772
403833000806	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
403833000807	lipoyl attachment site [posttranslational modification]; other site
403833000808	Predicted membrane protein [Function unknown]; Region: COG4684
403833000809	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
403833000810	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
403833000811	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
403833000812	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
403833000813	active site
403833000814	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
403833000815	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
403833000816	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
403833000817	tol-pal system beta propeller repeat protein TolB; Region: propeller_TolB; TIGR02800
403833000818	Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032
403833000819	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
403833000820	B12 binding site [chemical binding]; other site
403833000821	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
403833000822	FeS/SAM binding site; other site
403833000823	Domain of unknown function (DUF4070); Region: DUF4070; pfam13282
403833000824	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
403833000825	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
403833000826	active site
403833000827	catalytic site [active]
403833000828	HAD superfamily (subfamily IA) hydrolase, TIGR02254; Region: YjjG/YfnB
403833000829	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
403833000830	motif II; other site
403833000831	Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185
403833000832	homotrimer interaction site [polypeptide binding]; other site
403833000833	active site
403833000834	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
403833000835	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
403833000836	Translation initiation factor 2 (IF-2; GTPase) [Translation, ribosomal structure and biogenesis]; Region: InfB; COG0532
403833000837	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
403833000838	G1 box; other site
403833000839	putative GEF interaction site [polypeptide binding]; other site
403833000840	GTP/Mg2+ binding site [chemical binding]; other site
403833000841	Switch I region; other site
403833000842	G2 box; other site
403833000843	G3 box; other site
403833000844	Switch II region; other site
403833000845	G4 box; other site
403833000846	G5 box; other site
403833000847	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
403833000848	Translation-initiation factor 2; Region: IF-2; pfam11987
403833000849	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
403833000850	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
403833000851	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
403833000852	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
403833000853	catalytic residue [active]
403833000854	Phosphoglycerate dehydrogenase (PGDH) NAD-binding and catalytic domains; Region: PGDH_2; cd05303
403833000855	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
403833000856	putative ligand binding site [chemical binding]; other site
403833000857	NAD binding site [chemical binding]; other site
403833000858	dimerization interface [polypeptide binding]; other site
403833000859	catalytic site [active]
403833000860	Ferredoxin [Energy production and conversion]; Region: Fer; COG1141
403833000861	septum site-determining protein MinD; Region: minD_bact; TIGR01968
403833000862	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
403833000863	P-loop; other site
403833000864	ADP binding residues [chemical binding]; other site
403833000865	Switch I; other site
403833000866	Switch II; other site
403833000867	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
403833000868	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
403833000869	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
403833000870	Probable transposase; Region: OrfB_IS605; pfam01385
403833000871	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
403833000872	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
403833000873	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
403833000874	Q-loop/lid; other site
403833000875	ABC transporter signature motif; other site
403833000876	Walker B; other site
403833000877	D-loop; other site
403833000878	H-loop/switch region; other site
403833000879	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
403833000880	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_12; cd06347
403833000881	putative ligand binding site [chemical binding]; other site
403833000882	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
403833000883	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
403833000884	TM-ABC transporter signature motif; other site
403833000885	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
403833000886	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
403833000887	TM-ABC transporter signature motif; other site
403833000888	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
403833000889	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
403833000890	Walker A/P-loop; other site
403833000891	ATP binding site [chemical binding]; other site
403833000892	Q-loop/lid; other site
403833000893	ABC transporter signature motif; other site
403833000894	Walker B; other site
403833000895	D-loop; other site
403833000896	H-loop/switch region; other site
403833000897	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
403833000898	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
403833000899	Walker A/P-loop; other site
403833000900	ATP binding site [chemical binding]; other site
403833000901	Q-loop/lid; other site
403833000902	ABC transporter signature motif; other site
403833000903	Walker B; other site
403833000904	D-loop; other site
403833000905	H-loop/switch region; other site
403833000906	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
403833000907	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
403833000908	hydroxyglutarate oxidase; Provisional; Region: PRK11728
403833000909	Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17; Region: ALDH_F4-17_P5CDH; cd07123
403833000910	delta-1-pyrroline-5-carboxylate dehydrogenase, group 1; Region: D1pyr5carbox1; TIGR01236
403833000911	Glutamate binding site [chemical binding]; other site
403833000912	NAD binding site [chemical binding]; other site
403833000913	catalytic residues [active]
403833000914	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
403833000915	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
403833000916	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
403833000917	ABC-2 type transporter; Region: ABC2_membrane; cl17235
403833000918	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
403833000919	ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263
403833000920	Walker A/P-loop; other site
403833000921	ATP binding site [chemical binding]; other site
403833000922	Q-loop/lid; other site
403833000923	ABC transporter signature motif; other site
403833000924	Walker B; other site
403833000925	D-loop; other site
403833000926	H-loop/switch region; other site
403833000927	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
403833000928	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
403833000929	Glycerol-3-phosphate responsive antiterminator; Region: G3P_antiterm; cl00852
403833000930	Uncharacterized protein with conserved CXXC pairs [Function unknown]; Region: COG3862
403833000931	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
403833000932	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
403833000933	Predicted dehydrogenase [General function prediction only]; Region: COG0579
403833000934	hydroxyglutarate oxidase; Provisional; Region: PRK11728
403833000935	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
403833000936	glycerol kinase; Provisional; Region: glpK; PRK00047
403833000937	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
403833000938	N- and C-terminal domain interface [polypeptide binding]; other site
403833000939	active site
403833000940	MgATP binding site [chemical binding]; other site
403833000941	catalytic site [active]
403833000942	metal binding site [ion binding]; metal-binding site
403833000943	glycerol binding site [chemical binding]; other site
403833000944	homotetramer interface [polypeptide binding]; other site
403833000945	homodimer interface [polypeptide binding]; other site
403833000946	FBP binding site [chemical binding]; other site
403833000947	protein IIAGlc interface [polypeptide binding]; other site
403833000948	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
403833000949	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
403833000950	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
403833000951	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833000952	dimer interface [polypeptide binding]; other site
403833000953	conserved gate region; other site
403833000954	putative PBP binding loops; other site
403833000955	ABC-ATPase subunit interface; other site
403833000956	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833000957	dimer interface [polypeptide binding]; other site
403833000958	putative PBP binding loops; other site
403833000959	ABC-ATPase subunit interface; other site
403833000960	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
403833000961	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
403833000962	Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211
403833000963	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
403833000964	putative substrate translocation pore; other site
403833000965	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
403833000966	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
403833000967	Walker A/P-loop; other site
403833000968	ATP binding site [chemical binding]; other site
403833000969	Q-loop/lid; other site
403833000970	ABC transporter signature motif; other site
403833000971	Walker B; other site
403833000972	D-loop; other site
403833000973	H-loop/switch region; other site
403833000974	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
403833000975	putative substrate translocation pore; other site
403833000976	Uncharacterized conserved protein [Function unknown]; Region: COG4279
403833000977	SWIM zinc finger; Region: SWIM; pfam04434
403833000978	SNF2 Helicase protein; Region: DUF3670; pfam12419
403833000979	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
403833000980	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
403833000981	ATP binding site [chemical binding]; other site
403833000982	putative Mg++ binding site [ion binding]; other site
403833000983	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
403833000984	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
403833000985	nucleotide binding region [chemical binding]; other site
403833000986	ATP-binding site [chemical binding]; other site
403833000987	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
403833000988	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
403833000989	Walker A/P-loop; other site
403833000990	ATP binding site [chemical binding]; other site
403833000991	Q-loop/lid; other site
403833000992	ABC transporter signature motif; other site
403833000993	Walker B; other site
403833000994	D-loop; other site
403833000995	H-loop/switch region; other site
403833000996	GTPase Era; Reviewed; Region: era; PRK00089
403833000997	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
403833000998	G1 box; other site
403833000999	GTP/Mg2+ binding site [chemical binding]; other site
403833001000	Switch I region; other site
403833001001	G2 box; other site
403833001002	Switch II region; other site
403833001003	G3 box; other site
403833001004	G4 box; other site
403833001005	G5 box; other site
403833001006	KH domain; Region: KH_2; pfam07650
403833001007	Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707
403833001008	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
403833001009	active site
403833001010	phosphorylation site [posttranslational modification]
403833001011	intermolecular recognition site; other site
403833001012	dimerization interface [polypeptide binding]; other site
403833001013	ANTAR domain; Region: ANTAR; pfam03861
403833001014	GAF domain; Region: GAF_2; pfam13185
403833001015	GAF domain; Region: GAF_3; pfam13492
403833001016	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
403833001017	Histidine kinase; Region: HisKA_2; pfam07568
403833001018	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
403833001019	ATP binding site [chemical binding]; other site
403833001020	Mg2+ binding site [ion binding]; other site
403833001021	G-X-G motif; other site
403833001022	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
403833001023	Transposase; Region: DDE_Tnp_ISL3; pfam01610
403833001024	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3533
403833001025	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
403833001026	DNA-binding site [nucleotide binding]; DNA binding site
403833001027	Transcriptional regulators [Transcription]; Region: PurR; COG1609
403833001028	Ligand-binding domain of DNA transcription repressor specific for arabinose (AraR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AraR; cd01541
403833001029	putative dimerization interface [polypeptide binding]; other site
403833001030	putative ligand binding site [chemical binding]; other site
403833001031	Glycerol-1-phosphate dehydrogenase (G1PDH) catalyzes the reversible reduction of dihydroxyacetone phosphate (DHAP) to glycerol-1-phosphate (G1P) in an NADH-dependent manner; Region: G1PDH; cd08175
403833001032	Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371
403833001033	active site
403833001034	metal binding site [ion binding]; metal-binding site
403833001035	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
403833001036	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
403833001037	DNA-binding site [nucleotide binding]; DNA binding site
403833001038	UTRA domain; Region: UTRA; pfam07702
403833001039	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
403833001040	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
403833001041	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
403833001042	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
403833001043	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833001044	dimer interface [polypeptide binding]; other site
403833001045	conserved gate region; other site
403833001046	putative PBP binding loops; other site
403833001047	ABC-ATPase subunit interface; other site
403833001048	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
403833001049	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833001050	dimer interface [polypeptide binding]; other site
403833001051	conserved gate region; other site
403833001052	putative PBP binding loops; other site
403833001053	ABC-ATPase subunit interface; other site
403833001054	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
403833001055	homotrimer interaction site [polypeptide binding]; other site
403833001056	putative active site [active]
403833001057	tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238
403833001058	Tryptophanase family (Tnase). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to tryptophanase (Tnase) and tyrosine phenol-lyase (TPL). Tnase and TPL are...; Region: Tnase_like; cd00617
403833001059	substrate binding site [chemical binding]; other site
403833001060	tetramer interface [polypeptide binding]; other site
403833001061	catalytic residue [active]
403833001062	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
403833001063	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
403833001064	active site
403833001065	aspartate aminotransferase; Provisional; Region: PRK07568
403833001066	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
403833001067	pyridoxal 5'-phosphate binding site [chemical binding]; other site
403833001068	homodimer interface [polypeptide binding]; other site
403833001069	catalytic residue [active]
403833001070	ECF-type riboflavin transporter, S component; Region: ECF-ribofla_trS; pfam07155
403833001071	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
403833001072	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
403833001073	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
403833001074	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
403833001075	putative active site [active]
403833001076	putative metal binding site [ion binding]; other site
403833001077	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
403833001078	pyruvate phosphate dikinase; Provisional; Region: PRK09279
403833001079	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
403833001080	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
403833001081	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
403833001082	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
403833001083	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
403833001084	FAD binding site [chemical binding]; other site
403833001085	signal recognition particle protein; Provisional; Region: PRK10867
403833001086	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
403833001087	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
403833001088	P loop; other site
403833001089	GTP binding site [chemical binding]; other site
403833001090	Signal peptide binding domain; Region: SRP_SPB; pfam02978
403833001091	Ribosomal protein S16; Region: Ribosomal_S16; cl00368
403833001092	Predicted RNA-binding protein (contains KH domain) [General function prediction only]; Region: COG1837
403833001093	KH domain; Region: KH_4; pfam13083
403833001094	G-X-X-G motif; other site
403833001095	16S rRNA processing protein RimM; Region: 16S_RimM; TIGR02273
403833001096	RimM N-terminal domain; Region: RimM; pfam01782
403833001097	PRC-barrel domain; Region: PRC; pfam05239
403833001098	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
403833001099	SAM-dependent RNA methyltransferase; Region: Methyltrn_RNA_4; pfam09936
403833001100	Ribosomal protein L19; Region: Ribosomal_L19; cl00406
403833001101	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
403833001102	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
403833001103	Catalytic site [active]
403833001104	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
403833001105	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
403833001106	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
403833001107	S-adenosylmethionine binding site [chemical binding]; other site
403833001108	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
403833001109	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
403833001110	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
403833001111	Flagellar L-ring protein; Region: FlgH; cl17277
403833001112	SAF-like; Region: SAF_2; pfam13144
403833001113	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
403833001114	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
403833001115	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
403833001116	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
403833001117	Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786
403833001118	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855
403833001119	rod shape-determining protein MreB; Provisional; Region: PRK13930
403833001120	MreB and similar proteins; Region: MreB_like; cd10225
403833001121	nucleotide binding site [chemical binding]; other site
403833001122	Mg binding site [ion binding]; other site
403833001123	putative protofilament interaction site [polypeptide binding]; other site
403833001124	RodZ interaction site [polypeptide binding]; other site
403833001125	Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652
403833001126	Protein of unknown function (DUF3343); Region: DUF3343; pfam11823
403833001127	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
403833001128	DHH family; Region: DHH; pfam01368
403833001129	DHHA1 domain; Region: DHHA1; pfam02272
403833001130	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
403833001131	binding surface
403833001132	Tetratricopeptide repeat; Region: TPR_16; pfam13432
403833001133	TPR motif; other site
403833001134	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214
403833001135	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
403833001136	Fumarase C-terminus; Region: Fumerase_C; cl00795
403833001137	redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472
403833001138	Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971
403833001139	CoA binding domain; Region: CoA_binding; pfam02629
403833001140	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
403833001141	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
403833001142	HIGH motif; other site
403833001143	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
403833001144	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
403833001145	active site
403833001146	KMSKS motif; other site
403833001147	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
403833001148	tRNA binding surface [nucleotide binding]; other site
403833001149	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
403833001150	sensor kinase CusS; Provisional; Region: PRK09835
403833001151	RNA polymerase factor sigma-70; Validated; Region: PRK08295
403833001152	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
403833001153	DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771
403833001154	DNA binding residues [nucleotide binding]
403833001155	Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870
403833001156	pseudouridine synthase; Region: TIGR00093
403833001157	active site
403833001158	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
403833001159	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
403833001160	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
403833001161	active site
403833001162	HIGH motif; other site
403833001163	dimer interface [polypeptide binding]; other site
403833001164	KMSKS motif; other site
403833001165	flagellar capping protein; Validated; Region: fliD; PRK07737
403833001166	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
403833001167	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
403833001168	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
403833001169	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
403833001170	DNA-directed RNA polymerase subunit beta'; Provisional; Region: PRK00566
403833001171	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
403833001172	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
403833001173	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
403833001174	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
403833001175	Rpb1 (beta') - Rpb6 (omega) interaction site [polypeptide binding]; other site
403833001176	G-loop; other site
403833001177	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
403833001178	Rpb1 - Rpb5 interaction site [polypeptide binding]; other site
403833001179	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
403833001180	DNA binding site [nucleotide binding]
403833001181	clamp; other site
403833001182	Rpb1 - Rpb2 interaction site [polypeptide binding]; other site
403833001183	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
403833001184	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
403833001185	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
403833001186	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
403833001187	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
403833001188	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
403833001189	RPB10 interaction site [polypeptide binding]; other site
403833001190	RPB1 interaction site [polypeptide binding]; other site
403833001191	RPB11 interaction site [polypeptide binding]; other site
403833001192	RPB3 interaction site [polypeptide binding]; other site
403833001193	RPB12 interaction site [polypeptide binding]; other site
403833001194	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
403833001195	core dimer interface [polypeptide binding]; other site
403833001196	peripheral dimer interface [polypeptide binding]; other site
403833001197	L10 interface [polypeptide binding]; other site
403833001198	L11 interface [polypeptide binding]; other site
403833001199	putative EF-Tu interaction site [polypeptide binding]; other site
403833001200	putative EF-G interaction site [polypeptide binding]; other site
403833001201	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
403833001202	23S rRNA interface [nucleotide binding]; other site
403833001203	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
403833001204	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
403833001205	mRNA/rRNA interface [nucleotide binding]; other site
403833001206	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
403833001207	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
403833001208	23S rRNA interface [nucleotide binding]; other site
403833001209	L7/L12 interface [polypeptide binding]; other site
403833001210	putative thiostrepton binding site; other site
403833001211	L25 interface [polypeptide binding]; other site
403833001212	N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766
403833001213	N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766
403833001214	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
403833001215	heterodimer interface [polypeptide binding]; other site
403833001216	homodimer interface [polypeptide binding]; other site
403833001217	SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584
403833001218	Ribosomal protein L33; Region: Ribosomal_L33; pfam00471
403833001219	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
403833001220	Clp amino terminal domain; Region: Clp_N; pfam02861
403833001221	Clp amino terminal domain; Region: Clp_N; pfam02861
403833001222	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
403833001223	Walker A motif; other site
403833001224	ATP binding site [chemical binding]; other site
403833001225	Walker B motif; other site
403833001226	arginine finger; other site
403833001227	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
403833001228	Walker A motif; other site
403833001229	ATP binding site [chemical binding]; other site
403833001230	Walker B motif; other site
403833001231	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
403833001232	DNA repair protein RadA; Provisional; Region: PRK11823
403833001233	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
403833001234	Walker A motif; other site
403833001235	ATP binding site [chemical binding]; other site
403833001236	Walker B motif; other site
403833001237	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
403833001238	DNA integrity scanning protein DisA; Provisional; Region: PRK13482
403833001239	DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457
403833001240	DisA bacterial checkpoint controller linker region; Region: DisA-linker; pfam10635
403833001241	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cl14786
403833001242	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
403833001243	SmpB-tmRNA interface; other site
403833001244	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
403833001245	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
403833001246	Walker A/P-loop; other site
403833001247	ATP binding site [chemical binding]; other site
403833001248	Q-loop/lid; other site
403833001249	ABC transporter signature motif; other site
403833001250	Walker B; other site
403833001251	D-loop; other site
403833001252	H-loop/switch region; other site
403833001253	ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488
403833001254	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
403833001255	ABC transporter; Region: ABC_tran_2; pfam12848
403833001256	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
403833001257	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
403833001258	homodimer interface [polypeptide binding]; other site
403833001259	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
403833001260	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
403833001261	active site
403833001262	homodimer interface [polypeptide binding]; other site
403833001263	catalytic site [active]
403833001264	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
403833001265	MPT binding site; other site
403833001266	trimer interface [polypeptide binding]; other site
403833001267	MOSC domain; Region: MOSC; pfam03473
403833001268	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
403833001269	trimer interface [polypeptide binding]; other site
403833001270	dimer interface [polypeptide binding]; other site
403833001271	putative active site [active]
403833001272	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
403833001273	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
403833001274	FeS/SAM binding site; other site
403833001275	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
403833001276	putative molybdopterin biosynthesis protein MoeA/LysR substrate binding-domain-containing protein; Provisional; Region: PRK14498
403833001277	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
403833001278	dimer interface [polypeptide binding]; other site
403833001279	putative functional site; other site
403833001280	putative MPT binding site; other site
403833001281	PBP superfamily domain; Region: PBP_like; pfam12727
403833001282	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
403833001283	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
403833001284	dimer interface [polypeptide binding]; other site
403833001285	putative functional site; other site
403833001286	putative MPT binding site; other site
403833001287	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
403833001288	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
403833001289	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
403833001290	Walker A/P-loop; other site
403833001291	ATP binding site [chemical binding]; other site
403833001292	Q-loop/lid; other site
403833001293	ABC transporter signature motif; other site
403833001294	Walker B; other site
403833001295	D-loop; other site
403833001296	H-loop/switch region; other site
403833001297	TOBE domain; Region: TOBE; pfam03459
403833001298	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
403833001299	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833001300	dimer interface [polypeptide binding]; other site
403833001301	conserved gate region; other site
403833001302	putative PBP binding loops; other site
403833001303	ABC-ATPase subunit interface; other site
403833001304	molybdate ABC transporter periplasmic substrate-binding protein; Provisional; Region: PRK04168
403833001305	tungstate ABC transporter binding protein WtpA; Region: tungstate_WtpA; TIGR03730
403833001306	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
403833001307	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
403833001308	Aldehyde:ferredoxin oxidoreductase [Energy production and conversion]; Region: COG2414
403833001309	Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730
403833001310	Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314
403833001311	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
403833001312	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
403833001313	thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356
403833001314	ATP binding site [chemical binding]; other site
403833001315	substrate interface [chemical binding]; other site
403833001316	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
403833001317	MoaE interaction surface [polypeptide binding]; other site
403833001318	MoeB interaction surface [polypeptide binding]; other site
403833001319	thiocarboxylated glycine; other site
403833001320	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
403833001321	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
403833001322	GTP binding site; other site
403833001323	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
403833001324	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
403833001325	catalytic loop [active]
403833001326	iron binding site [ion binding]; other site
403833001327	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
403833001328	4Fe-4S binding domain; Region: Fer4; pfam00037
403833001329	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
403833001330	[4Fe-4S] binding site [ion binding]; other site
403833001331	molybdopterin cofactor binding site; other site
403833001332	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
403833001333	molybdopterin cofactor binding site; other site
403833001334	Uncharacterized conserved protein [Function unknown]; Region: COG5276
403833001335	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
403833001336	putative CheA interaction surface; other site
403833001337	Cupin domain; Region: Cupin_2; pfam07883
403833001338	Global regulator protein family; Region: CsrA; pfam02599
403833001339	flagellar assembly protein FliW; Provisional; Region: PRK13285
403833001340	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701
403833001341	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
403833001342	flagellar hook-associated protein FlgK; Region: flgK_ends; TIGR02492
403833001343	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
403833001344	Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316
403833001345	peroxiredoxin; Provisional; Region: PRK13189
403833001346	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
403833001347	dimer interface [polypeptide binding]; other site
403833001348	decamer (pentamer of dimers) interface [polypeptide binding]; other site
403833001349	catalytic triad [active]
403833001350	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
403833001351	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
403833001352	Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092
403833001353	active site
403833001354	Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
403833001355	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
403833001356	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
403833001357	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
403833001358	TPR motif; other site
403833001359	Tetratricopeptide repeat; Region: TPR_12; pfam13424
403833001360	binding surface
403833001361	TPR repeat; Region: TPR_11; pfam13414
403833001362	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
403833001363	binding surface
403833001364	TPR motif; other site
403833001365	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
403833001366	binding surface
403833001367	TPR repeat; Region: TPR_11; pfam13414
403833001368	TPR motif; other site
403833001369	Cornifin (SPRR) family; Region: Cornifin; pfam02389
403833001370	Tetratricopeptide repeat; Region: TPR_12; pfam13424
403833001371	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
403833001372	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
403833001373	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
403833001374	S-adenosylmethionine binding site [chemical binding]; other site
403833001375	DNA methylase; Region: N6_N4_Mtase; pfam01555
403833001376	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
403833001377	Domain of unknown function DUF87; Region: DUF87; pfam01935
403833001378	HerA helicase [Replication, recombination, and repair]; Region: COG0433
403833001379	Transposase [DNA replication, recombination, and repair]; Region: COG5421
403833001380	Transposase [DNA replication, recombination, and repair]; Region: COG5421
403833001381	MOSC domain; Region: MOSC; pfam03473
403833001382	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
403833001383	arsenical-resistance protein; Region: acr3; TIGR00832
403833001384	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
403833001385	dimerization interface [polypeptide binding]; other site
403833001386	putative DNA binding site [nucleotide binding]; other site
403833001387	putative Zn2+ binding site [ion binding]; other site
403833001388	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
403833001389	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
403833001390	putative substrate translocation pore; other site
403833001391	AAA domain; Region: AAA_21; pfam13304
403833001392	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
403833001393	Holin family; Region: Phage_holin_4; pfam05105
403833001394	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
403833001395	amidase catalytic site [active]
403833001396	Zn binding residues [ion binding]; other site
403833001397	substrate binding site [chemical binding]; other site
403833001398	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
403833001399	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
403833001400	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
403833001401	putative active site [active]
403833001402	putative NTP binding site [chemical binding]; other site
403833001403	putative nucleic acid binding site [nucleotide binding]; other site
403833001404	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
403833001405	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
403833001406	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
403833001407	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
403833001408	catalytic residues [active]
403833001409	catalytic nucleophile [active]
403833001410	Recombinase; Region: Recombinase; pfam07508
403833001411	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
403833001412	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
403833001413	Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338
403833001414	catalytic residues [active]
403833001415	catalytic nucleophile [active]
403833001416	Recombinase; Region: Recombinase; pfam07508
403833001417	Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408
403833001418	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
403833001419	dimerization interface [polypeptide binding]; other site
403833001420	putative DNA binding site [nucleotide binding]; other site
403833001421	putative Zn2+ binding site [ion binding]; other site
403833001422	Heavy-metal-associated domain; Region: HMA; pfam00403
403833001423	metal-binding site [ion binding]
403833001424	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
403833001425	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
403833001426	metal-binding site [ion binding]
403833001427	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
403833001428	Soluble P-type ATPase [General function prediction only]; Region: COG4087
403833001429	lipoprotein signal peptidase; Provisional; Region: PRK14786
403833001430	lipoprotein signal peptidase; Provisional; Region: PRK14787
403833001431	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
403833001432	SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834
403833001433	active site
403833001434	catalytic triad [active]
403833001435	oxyanion hole [active]
403833001436	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
403833001437	Sodium Bile acid symporter family; Region: SBF; cl17470
403833001438	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
403833001439	dimerization interface [polypeptide binding]; other site
403833001440	putative DNA binding site [nucleotide binding]; other site
403833001441	putative Zn2+ binding site [ion binding]; other site
403833001442	Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738
403833001443	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
403833001444	putative substrate translocation pore; other site
403833001445	putative acetyltransferase; Provisional; Region: PRK03624
403833001446	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
403833001447	Coenzyme A binding pocket [chemical binding]; other site
403833001448	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
403833001449	Gluconate kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_GntK; cd07770
403833001450	N- and C-terminal domain interface [polypeptide binding]; other site
403833001451	active site
403833001452	catalytic site [active]
403833001453	metal binding site [ion binding]; metal-binding site
403833001454	carbohydrate binding site [chemical binding]; other site
403833001455	ATP binding site [chemical binding]; other site
403833001456	Putative D-isomer specific 2-hydroxyacid dehydrogenases, NAD-binding and catalytic domains; Region: 2-Hacid_dh_12; cd12177
403833001457	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
403833001458	putative ligand binding site [chemical binding]; other site
403833001459	putative NAD binding site [chemical binding]; other site
403833001460	catalytic site [active]
403833001461	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
403833001462	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
403833001463	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
403833001464	D-mannonate oxidoreductase; Provisional; Region: PRK08277
403833001465	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
403833001466	NAD(P) binding site [chemical binding]; other site
403833001467	active site
403833001468	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
403833001469	GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929
403833001470	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
403833001471	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
403833001472	active site
403833001473	metal binding site [ion binding]; metal-binding site
403833001474	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
403833001475	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
403833001476	putative ligand binding site [chemical binding]; other site
403833001477	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
403833001478	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
403833001479	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
403833001480	motif II; other site
403833001481	FtsH Extracellular; Region: FtsH_ext; pfam06480
403833001482	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
403833001483	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
403833001484	Walker A motif; other site
403833001485	ATP binding site [chemical binding]; other site
403833001486	Walker B motif; other site
403833001487	arginine finger; other site
403833001488	Peptidase family M41; Region: Peptidase_M41; pfam01434
403833001489	Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731
403833001490	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
403833001491	FeS/SAM binding site; other site
403833001492	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
403833001493	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
403833001494	2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710
403833001495	Pyruvate ferredoxin/flavodoxin oxidoreductase; Region: POR; pfam01558
403833001496	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
403833001497	dimer interface [polypeptide binding]; other site
403833001498	PYR/PP interface [polypeptide binding]; other site
403833001499	TPP binding site [chemical binding]; other site
403833001500	substrate binding site [chemical binding]; other site
403833001501	2-oxoacid ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11869
403833001502	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
403833001503	TPP-binding site [chemical binding]; other site
403833001504	Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367
403833001505	Peroxiredoxin (PRX) family, AhpE-like subfamily; composed of proteins similar to Mycobacterium tuberculosis AhpE. AhpE is described as a 1-cys PRX because of the absence of a resolving cysteine. The structure and sequence of AhpE, however, show greater...; Region: PRX_AhpE_like; cd03018
403833001506	dimer interface [polypeptide binding]; other site
403833001507	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
403833001508	catalytic triad [active]
403833001509	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
403833001510	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
403833001511	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
403833001512	Alpha amylase catalytic domain found in maltosyltransferase; Region: AmyAc_MTase_N; cd11335
403833001513	homodimer interface [polypeptide binding]; other site
403833001514	active site
403833001515	catalytic site [active]
403833001516	maltose binding site 2 [chemical binding]; other site
403833001517	polyphosphate kinase; Provisional; Region: PRK05443
403833001518	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
403833001519	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
403833001520	Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165
403833001521	putative domain interface [polypeptide binding]; other site
403833001522	putative active site [active]
403833001523	catalytic site [active]
403833001524	Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168
403833001525	putative domain interface [polypeptide binding]; other site
403833001526	putative active site [active]
403833001527	catalytic site [active]
403833001528	Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248
403833001529	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
403833001530	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
403833001531	Zn2+ binding site [ion binding]; other site
403833001532	Mg2+ binding site [ion binding]; other site
403833001533	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
403833001534	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
403833001535	CHAD domain; Region: CHAD; pfam05235
403833001536	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
403833001537	catalytic core [active]
403833001538	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
403833001539	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
403833001540	Beta-lactamase; Region: Beta-lactamase; pfam00144
403833001541	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
403833001542	beta-N-acetylglucosaminidase; Region: NAGidase; pfam07555
403833001543	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
403833001544	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
403833001545	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833001546	dimer interface [polypeptide binding]; other site
403833001547	conserved gate region; other site
403833001548	putative PBP binding loops; other site
403833001549	ABC-ATPase subunit interface; other site
403833001550	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
403833001551	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833001552	dimer interface [polypeptide binding]; other site
403833001553	conserved gate region; other site
403833001554	putative PBP binding loops; other site
403833001555	ABC-ATPase subunit interface; other site
403833001556	SH3 domain of the SH3b1 type; Region: SH3_6; pfam12913
403833001557	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
403833001558	NlpC/P60 family; Region: NLPC_P60; cl17555
403833001559	diaminopimelate decarboxylase; Region: lysA; TIGR01048
403833001560	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
403833001561	active site
403833001562	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
403833001563	substrate binding site [chemical binding]; other site
403833001564	catalytic residues [active]
403833001565	dimer interface [polypeptide binding]; other site
403833001566	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
403833001567	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
403833001568	Walker A/P-loop; other site
403833001569	ATP binding site [chemical binding]; other site
403833001570	Q-loop/lid; other site
403833001571	ABC transporter signature motif; other site
403833001572	Walker B; other site
403833001573	D-loop; other site
403833001574	H-loop/switch region; other site
403833001575	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
403833001576	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
403833001577	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
403833001578	Walker A/P-loop; other site
403833001579	ATP binding site [chemical binding]; other site
403833001580	Q-loop/lid; other site
403833001581	ABC transporter signature motif; other site
403833001582	Walker B; other site
403833001583	D-loop; other site
403833001584	H-loop/switch region; other site
403833001585	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
403833001586	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
403833001587	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833001588	dimer interface [polypeptide binding]; other site
403833001589	conserved gate region; other site
403833001590	putative PBP binding loops; other site
403833001591	ABC-ATPase subunit interface; other site
403833001592	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
403833001593	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833001594	dimer interface [polypeptide binding]; other site
403833001595	conserved gate region; other site
403833001596	putative PBP binding loops; other site
403833001597	ABC-ATPase subunit interface; other site
403833001598	The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509
403833001599	substrate binding site [chemical binding]; other site
403833001600	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
403833001601	Protein of unknown function (DUF1343); Region: DUF1343; pfam07075
403833001602	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
403833001603	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
403833001604	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
403833001605	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
403833001606	putative active site [active]
403833001607	hypothetical protein; Provisional; Region: PRK08609
403833001608	Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141
403833001609	active site
403833001610	primer binding site [nucleotide binding]; other site
403833001611	NTP  binding site [chemical binding]; other site
403833001612	metal binding triad [ion binding]; metal-binding site
403833001613	Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436
403833001614	active site
403833001615	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
403833001616	Coenzyme A binding pocket [chemical binding]; other site
403833001617	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
403833001618	The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509
403833001619	substrate binding site [chemical binding]; other site
403833001620	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
403833001621	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833001622	dimer interface [polypeptide binding]; other site
403833001623	conserved gate region; other site
403833001624	putative PBP binding loops; other site
403833001625	ABC-ATPase subunit interface; other site
403833001626	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
403833001627	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833001628	putative PBP binding loops; other site
403833001629	ABC-ATPase subunit interface; other site
403833001630	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
403833001631	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
403833001632	Walker A/P-loop; other site
403833001633	ATP binding site [chemical binding]; other site
403833001634	Q-loop/lid; other site
403833001635	ABC transporter signature motif; other site
403833001636	Walker B; other site
403833001637	D-loop; other site
403833001638	H-loop/switch region; other site
403833001639	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
403833001640	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
403833001641	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
403833001642	Walker A/P-loop; other site
403833001643	ATP binding site [chemical binding]; other site
403833001644	Q-loop/lid; other site
403833001645	ABC transporter signature motif; other site
403833001646	Walker B; other site
403833001647	D-loop; other site
403833001648	H-loop/switch region; other site
403833001649	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
403833001650	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; pfam00232
403833001651	beta-galactosidase; Region: BGL; TIGR03356
403833001652	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
403833001653	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
403833001654	dimerization interface [polypeptide binding]; other site
403833001655	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
403833001656	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
403833001657	dimer interface [polypeptide binding]; other site
403833001658	putative CheW interface [polypeptide binding]; other site
403833001659	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
403833001660	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
403833001661	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
403833001662	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
403833001663	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
403833001664	active site
403833001665	Transcriptional regulators [Transcription]; Region: PurR; COG1609
403833001666	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
403833001667	DNA binding site [nucleotide binding]
403833001668	domain linker motif; other site
403833001669	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
403833001670	ligand binding site [chemical binding]; other site
403833001671	dimerization interface [polypeptide binding]; other site
403833001672	Peptidase M55, D-aminopeptidase dipeptide-binding protein family; Region: DAP_dppA_2; cd08769
403833001673	SxDxEG motif; other site
403833001674	putative active site [active]
403833001675	putative metal binding site [ion binding]; other site
403833001676	methionine sulfoxide reductase A; Provisional; Region: PRK14054
403833001677	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
403833001678	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
403833001679	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
403833001680	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
403833001681	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
403833001682	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
403833001683	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
403833001684	TM-ABC transporter signature motif; other site
403833001685	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
403833001686	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
403833001687	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
403833001688	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
403833001689	TM-ABC transporter signature motif; other site
403833001690	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
403833001691	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
403833001692	Walker A/P-loop; other site
403833001693	ATP binding site [chemical binding]; other site
403833001694	Q-loop/lid; other site
403833001695	ABC transporter signature motif; other site
403833001696	Walker B; other site
403833001697	D-loop; other site
403833001698	H-loop/switch region; other site
403833001699	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
403833001700	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
403833001701	Walker A/P-loop; other site
403833001702	ATP binding site [chemical binding]; other site
403833001703	Q-loop/lid; other site
403833001704	ABC transporter signature motif; other site
403833001705	Walker B; other site
403833001706	D-loop; other site
403833001707	H-loop/switch region; other site
403833001708	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_8; cd06343
403833001709	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
403833001710	putative ligand binding site [chemical binding]; other site
403833001711	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
403833001712	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
403833001713	dimerization interface [polypeptide binding]; other site
403833001714	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
403833001715	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
403833001716	dimer interface [polypeptide binding]; other site
403833001717	putative CheW interface [polypeptide binding]; other site
403833001718	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
403833001719	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
403833001720	Walker A/P-loop; other site
403833001721	ATP binding site [chemical binding]; other site
403833001722	Q-loop/lid; other site
403833001723	ABC transporter signature motif; other site
403833001724	Walker B; other site
403833001725	D-loop; other site
403833001726	H-loop/switch region; other site
403833001727	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
403833001728	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
403833001729	Walker A/P-loop; other site
403833001730	ATP binding site [chemical binding]; other site
403833001731	Q-loop/lid; other site
403833001732	ABC transporter signature motif; other site
403833001733	Walker B; other site
403833001734	D-loop; other site
403833001735	H-loop/switch region; other site
403833001736	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
403833001737	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
403833001738	TM-ABC transporter signature motif; other site
403833001739	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
403833001740	TM-ABC transporter signature motif; other site
403833001741	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
403833001742	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
403833001743	putative acyltransferase; Provisional; Region: PRK05790
403833001744	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
403833001745	dimer interface [polypeptide binding]; other site
403833001746	active site
403833001747	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
403833001748	Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550
403833001749	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
403833001750	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
403833001751	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
403833001752	NAD(P) binding site [chemical binding]; other site
403833001753	homotetramer interface [polypeptide binding]; other site
403833001754	homodimer interface [polypeptide binding]; other site
403833001755	active site
403833001756	hypothetical protein; Validated; Region: PRK06840
403833001757	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
403833001758	active site
403833001759	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
403833001760	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
403833001761	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
403833001762	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
403833001763	putative active site cavity [active]
403833001764	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
403833001765	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
403833001766	nucleotide binding site [chemical binding]; other site
403833001767	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
403833001768	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
403833001769	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
403833001770	putative active site [active]
403833001771	FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831
403833001772	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
403833001773	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
403833001774	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
403833001775	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833001776	dimer interface [polypeptide binding]; other site
403833001777	conserved gate region; other site
403833001778	putative PBP binding loops; other site
403833001779	ABC-ATPase subunit interface; other site
403833001780	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
403833001781	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833001782	dimer interface [polypeptide binding]; other site
403833001783	conserved gate region; other site
403833001784	putative PBP binding loops; other site
403833001785	ABC-ATPase subunit interface; other site
403833001786	Protein of unknown function (DUF4127); Region: DUF4127; pfam13552
403833001787	Transposase; Region: DEDD_Tnp_IS110; pfam01548
403833001788	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
403833001789	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
403833001790	ribosome maturation protein RimP; Reviewed; Region: PRK00092
403833001791	Sm and related proteins; Region: Sm_like; cl00259
403833001792	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
403833001793	putative oligomer interface [polypeptide binding]; other site
403833001794	putative RNA binding site [nucleotide binding]; other site
403833001795	transcription termination factor NusA; Region: NusA; TIGR01953
403833001796	NusA N-terminal domain; Region: NusA_N; pfam08529
403833001797	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
403833001798	RNA binding site [nucleotide binding]; other site
403833001799	homodimer interface [polypeptide binding]; other site
403833001800	NusA-like KH domain; Region: KH_5; pfam13184
403833001801	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
403833001802	G-X-X-G motif; other site
403833001803	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
403833001804	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
403833001805	dimer interface [polypeptide binding]; other site
403833001806	active site
403833001807	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
403833001808	catalytic residues [active]
403833001809	substrate binding site [chemical binding]; other site
403833001810	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
403833001811	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
403833001812	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
403833001813	putative active site [active]
403833001814	putative CoA binding site [chemical binding]; other site
403833001815	nudix motif; other site
403833001816	metal binding site [ion binding]; metal-binding site
403833001817	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
403833001818	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
403833001819	MOFRL family; Region: MOFRL; pfam05161
403833001820	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
403833001821	fructuronate transporter; Provisional; Region: PRK10034; cl15264
403833001822	Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065
403833001823	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
403833001824	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
403833001825	metal binding site [ion binding]; metal-binding site
403833001826	active site
403833001827	I-site; other site
403833001828	ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606
403833001829	Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which  binds to Adenosine nucleotide; Region: AANH_like; cl00292
403833001830	Ligand Binding Site [chemical binding]; other site
403833001831	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
403833001832	PAS domain; Region: PAS_9; pfam13426
403833001833	putative active site [active]
403833001834	heme pocket [chemical binding]; other site
403833001835	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
403833001836	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
403833001837	metal binding site [ion binding]; metal-binding site
403833001838	active site
403833001839	I-site; other site
403833001840	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
403833001841	Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421
403833001842	Membrane transport protein; Region: Mem_trans; cl09117
403833001843	Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506
403833001844	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
403833001845	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
403833001846	Walker A/P-loop; other site
403833001847	ATP binding site [chemical binding]; other site
403833001848	Q-loop/lid; other site
403833001849	ABC transporter signature motif; other site
403833001850	Walker B; other site
403833001851	D-loop; other site
403833001852	H-loop/switch region; other site
403833001853	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
403833001854	Peptidase family U32; Region: Peptidase_U32; pfam01136
403833001855	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
403833001856	Domain of unknown function DUF20; Region: UPF0118; pfam01594
403833001857	Domain of unknown function (DUF4416); Region: DUF4416; pfam14385
403833001858	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, isobutyryl-CoA mutase (ICM)-like subfamily; contains archaeal and bacterial proteins similar to the large subunit of Streptomyces cinnamonensis coenzyme B12-dependent ICM. ICM...; Region: MM_CoA_mutase_ICM_like; cd03680
403833001859	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
403833001860	B12 binding site [chemical binding]; other site
403833001861	cobalt ligand [ion binding]; other site
403833001862	Putative periplasmic protein kinase ArgK and related GTPases of G3E family [Amino acid transport and metabolism]; Region: ArgK; COG1703
403833001863	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
403833001864	Walker A; other site
403833001865	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
403833001866	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
403833001867	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
403833001868	dimer interface [polypeptide binding]; other site
403833001869	substrate binding site [chemical binding]; other site
403833001870	metal binding site [ion binding]; metal-binding site
403833001871	methylmalonyl-CoA decarboxylase alpha subunit; Region: mmdA; TIGR01117
403833001872	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
403833001873	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
403833001874	putative acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK05641
403833001875	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
403833001876	carboxyltransferase (CT) interaction site; other site
403833001877	biotinylation site [posttranslational modification]; other site
403833001878	Ion channel; Region: Ion_trans_2; pfam07885
403833001879	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
403833001880	TrkA-N domain; Region: TrkA_N; pfam02254
403833001881	TrkA-C domain; Region: TrkA_C; pfam02080
403833001882	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
403833001883	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
403833001884	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
403833001885	dimer interface [polypeptide binding]; other site
403833001886	ssDNA binding site [nucleotide binding]; other site
403833001887	tetramer (dimer of dimers) interface [polypeptide binding]; other site
403833001888	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
403833001889	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
403833001890	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
403833001891	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
403833001892	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
403833001893	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
403833001894	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
403833001895	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
403833001896	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
403833001897	Glutaredoxin-like domain protein; Region: GlrX_arch; TIGR02187
403833001898	Thioredoxin (TRX)-Glutaredoxin (GRX)-like family; composed of archaeal and bacterial proteins that show similarity to both TRX and GRX, including the C-terminal TRX-fold subdomain of Pyrococcus furiosus protein disulfide oxidoreductase (PfPDO). All...; Region: TRX_GRX_like; cd02973
403833001899	catalytic residues [active]
403833001900	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
403833001901	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
403833001902	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
403833001903	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
403833001904	16S/18S rRNA binding site [nucleotide binding]; other site
403833001905	S13e-L30e interaction site [polypeptide binding]; other site
403833001906	25S rRNA binding site [nucleotide binding]; other site
403833001907	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
403833001908	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
403833001909	RNase E interface [polypeptide binding]; other site
403833001910	trimer interface [polypeptide binding]; other site
403833001911	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
403833001912	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
403833001913	RNase E interface [polypeptide binding]; other site
403833001914	trimer interface [polypeptide binding]; other site
403833001915	active site
403833001916	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
403833001917	putative nucleic acid binding region [nucleotide binding]; other site
403833001918	G-X-X-G motif; other site
403833001919	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
403833001920	RNA binding site [nucleotide binding]; other site
403833001921	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
403833001922	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
403833001923	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
403833001924	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
403833001925	Zn2+ binding site [ion binding]; other site
403833001926	Mg2+ binding site [ion binding]; other site
403833001927	manganese transport transcriptional regulator; Provisional; Region: PRK03902
403833001928	Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325
403833001929	Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742
403833001930	FeoA domain; Region: FeoA; pfam04023
403833001931	purine nucleoside phosphorylase; Provisional; Region: PRK08202
403833001932	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
403833001933	DHH family; Region: DHH; pfam01368
403833001934	DHHA1 domain; Region: DHHA1; pfam02272
403833001935	Na+/H+ ion antiporter subunit; Region: MNHE; cl00807
403833001936	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334
403833001937	Domain of unknown function (DUF4040); Region: DUF4040; pfam13244
403833001938	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
403833001939	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375
403833001940	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
403833001941	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
403833001942	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
403833001943	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
403833001944	pyruvate ferredoxin oxidoreductase subunit beta; Provisional; Region: PRK11865
403833001945	Thiamine pyrophosphate (TPP family), PFOR porB-like subfamily, TPP-binding module; composed of proteins similar to the beta subunit (porB) of the Helicobacter pylori four-subunit pyruvate ferredoxin oxidoreductase (PFOR), which are also found in archaea...; Region: TPP_PFOR_porB_like; cd03376
403833001946	TPP-binding site [chemical binding]; other site
403833001947	putative dimer interface [polypeptide binding]; other site
403833001948	pyruvate flavodoxin oxidoreductase subunit alpha; Reviewed; Region: porA; PRK09622
403833001949	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
403833001950	dimer interface [polypeptide binding]; other site
403833001951	PYR/PP interface [polypeptide binding]; other site
403833001952	TPP binding site [chemical binding]; other site
403833001953	substrate binding site [chemical binding]; other site
403833001954	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, delta subunit [Energy production and conversion]; Region: COG1144
403833001955	4Fe-4S binding domain; Region: Fer4; pfam00037
403833001956	2-oxoacid:acceptor oxidoreductase, gamma subunit, pyruvate/2-ketoisovalerate family; Region: PorC_KorC; TIGR02175
403833001957	pyruvate/ketoisovalerate ferredoxin oxidoreductase subunit gamma; Provisional; Region: PRK14029
403833001958	Uncharacterized conserved protein [Function unknown]; Region: COG1543
403833001959	N-terminal catalytic domain of  alpha-amylase ( AmyC ) and similar proteins; Region: GH57N_AmyC_like; cd10792
403833001960	active site
403833001961	substrate binding site [chemical binding]; other site
403833001962	catalytic site [active]
403833001963	Domain of unknown function (DUF1957); Region: DUF1957; pfam09210
403833001964	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330
403833001965	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
403833001966	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
403833001967	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
403833001968	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
403833001969	Flavoprotein; Region: Flavoprotein; pfam02441
403833001970	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
403833001971	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
403833001972	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
403833001973	HIGH motif; other site
403833001974	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
403833001975	active site
403833001976	KMSKS motif; other site
403833001977	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
403833001978	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
403833001979	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
403833001980	Walker A/P-loop; other site
403833001981	ATP binding site [chemical binding]; other site
403833001982	Q-loop/lid; other site
403833001983	ABC transporter signature motif; other site
403833001984	Walker B; other site
403833001985	D-loop; other site
403833001986	H-loop/switch region; other site
403833001987	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
403833001988	rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566
403833001989	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
403833001990	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
403833001991	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cl00258
403833001992	metal binding site [ion binding]; metal-binding site
403833001993	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
403833001994	This family is most closely related to the GT1 family of glycosyltransferases. UDP-glucose-diacylglycerol glucosyltransferase (UGDG; also known as 1,2-diacylglycerol 3-glucosyltransferase) catalyzes the transfer of glucose from UDP-glucose to 1; Region: GT1_UGDG_like; cd03817
403833001995	putative ADP-binding pocket [chemical binding]; other site
403833001996	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
403833001997	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
403833001998	ATP binding site [chemical binding]; other site
403833001999	Mg2+ binding site [ion binding]; other site
403833002000	G-X-G motif; other site
403833002001	MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782
403833002002	ATP binding site [chemical binding]; other site
403833002003	MutL C terminal dimerisation domain; Region: MutL_C; smart00853
403833002004	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
403833002005	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
403833002006	active site
403833002007	metal binding site [ion binding]; metal-binding site
403833002008	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
403833002009	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558
403833002010	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
403833002011	active site
403833002012	metal binding site [ion binding]; metal-binding site
403833002013	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
403833002014	Protein of unknown function DUF89; Region: DUF89; cl15397
403833002015	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
403833002016	Ribonuclease P; Region: Ribonuclease_P; pfam00825
403833002017	Haemolytic domain; Region: Haemolytic; pfam01809
403833002018	Preprotein translocase subunit YidC [Intracellular trafficking and secretion]; Region: YidC; COG0706
403833002019	60Kd inner membrane protein; Region: 60KD_IMP; pfam02096
403833002020	Predicted RNA-binding protein [General function prediction only]; Region: Jag; COG1847
403833002021	jag_K homology RNA-binding domain. The KH domain is found in proteins homologous to the Bacillus subtilis protein Jag, which is associated with SpoIIIJ and is necessary for the third stage of sporulation.  The KH motif is a beta-alpha-alpha-beta-beta...; Region: jag_KH; cd02414
403833002022	G-X-X-G motif; other site
403833002023	R3H domain found in proteins homologous to Bacillus subtilus Jag, which is associated with SpoIIIJ. SpoIIIJ is necessary for the third stage of sporulation. The name of the R3H domain comes from the characteristic spacing of the most conserved arginine...; Region: R3H_jag; cd02644
403833002024	RxxxH motif; other site
403833002025	RNA polymerase sigma factor RpoD; Validated; Region: PRK09210
403833002026	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
403833002027	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
403833002028	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
403833002029	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
403833002030	DNA binding residues [nucleotide binding]
403833002031	electron transport complex, RnfABCDGE type, C subunit; Region: rnfC; TIGR01945
403833002032	SLBB domain; Region: SLBB; pfam10531
403833002033	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
403833002034	NQR2, RnfD, RnfE family; Region: NQR2_RnfD_RnfE; pfam03116
403833002035	FMN-binding domain; Region: FMN_bind; cl01081
403833002036	electron transport complex RsxE subunit; Provisional; Region: PRK12405
403833002037	Rnf-Nqr subunit, membrane protein; Region: Rnf-Nqr; cl00597
403833002038	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
403833002039	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
403833002040	active site
403833002041	metal binding site [ion binding]; metal-binding site
403833002042	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
403833002043	ribosome recycling factor; Reviewed; Region: frr; PRK00083
403833002044	hinge region; other site
403833002045	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230
403833002046	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
403833002047	catalytic residue [active]
403833002048	putative FPP diphosphate  binding site; other site
403833002049	putative FPP binding hydrophobic cleft; other site
403833002050	dimer interface [polypeptide binding]; other site
403833002051	putative IPP diphosphate binding site; other site
403833002052	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
403833002053	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
403833002054	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
403833002055	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
403833002056	motif 1; other site
403833002057	active site
403833002058	motif 2; other site
403833002059	motif 3; other site
403833002060	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
403833002061	DHHA1 domain; Region: DHHA1; pfam02272
403833002062	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
403833002063	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
403833002064	active site
403833002065	nucleophile elbow; other site
403833002066	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
403833002067	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
403833002068	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
403833002069	Transposase; Region: DDE_Tnp_ISL3; pfam01610
403833002070	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
403833002071	Transposase; Region: DDE_Tnp_ISL3; pfam01610
403833002072	Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542
403833002073	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
403833002074	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
403833002075	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
403833002076	Methylthioribose-binding protein-like of ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_methylthioribose_binding_like; cd06305
403833002077	putative ligand binding site [chemical binding]; other site
403833002078	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
403833002079	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
403833002080	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
403833002081	Walker A/P-loop; other site
403833002082	ATP binding site [chemical binding]; other site
403833002083	Q-loop/lid; other site
403833002084	ABC transporter signature motif; other site
403833002085	Walker B; other site
403833002086	D-loop; other site
403833002087	H-loop/switch region; other site
403833002088	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
403833002089	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
403833002090	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
403833002091	TM-ABC transporter signature motif; other site
403833002092	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
403833002093	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
403833002094	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
403833002095	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
403833002096	methylthioribose kinase; Reviewed; Region: mtnK; PRK09550
403833002097	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
403833002098	intersubunit interface [polypeptide binding]; other site
403833002099	active site
403833002100	Zn2+ binding site [ion binding]; other site
403833002101	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
403833002102	Transposase; Region: DEDD_Tnp_IS110; pfam01548
403833002103	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
403833002104	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
403833002105	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
403833002106	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
403833002107	intersubunit interface [polypeptide binding]; other site
403833002108	active site
403833002109	zinc binding site [ion binding]; other site
403833002110	Na+ binding site [ion binding]; other site
403833002111	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
403833002112	propionate/acetate kinase; Provisional; Region: PRK12379
403833002113	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
403833002114	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
403833002115	trimer interface [polypeptide binding]; other site
403833002116	putative metal binding site [ion binding]; other site
403833002117	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
403833002118	active site
403833002119	hypothetical protein; Provisional; Region: PRK06361
403833002120	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
403833002121	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
403833002122	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
403833002123	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
403833002124	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
403833002125	DNA binding residues [nucleotide binding]
403833002126	CoA binding domain; Region: CoA_binding_2; pfam13380
403833002127	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
403833002128	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
403833002129	trimerization site [polypeptide binding]; other site
403833002130	active site
403833002131	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
403833002132	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
403833002133	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
403833002134	catalytic residue [active]
403833002135	FeS assembly protein SufD; Region: sufD; TIGR01981
403833002136	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
403833002137	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
403833002138	FeS assembly protein SufB; Region: sufB; TIGR01980
403833002139	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
403833002140	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
403833002141	Walker A/P-loop; other site
403833002142	ATP binding site [chemical binding]; other site
403833002143	Q-loop/lid; other site
403833002144	ABC transporter signature motif; other site
403833002145	Walker B; other site
403833002146	D-loop; other site
403833002147	H-loop/switch region; other site
403833002148	Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740
403833002149	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
403833002150	heterodimer interface [polypeptide binding]; other site
403833002151	active site
403833002152	FMN binding site [chemical binding]; other site
403833002153	homodimer interface [polypeptide binding]; other site
403833002154	substrate binding site [chemical binding]; other site
403833002155	dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054
403833002156	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218
403833002157	FAD binding pocket [chemical binding]; other site
403833002158	FAD binding motif [chemical binding]; other site
403833002159	phosphate binding motif [ion binding]; other site
403833002160	beta-alpha-beta structure motif; other site
403833002161	NAD binding pocket [chemical binding]; other site
403833002162	Iron coordination center [ion binding]; other site
403833002163	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
403833002164	active site
403833002165	dimer interface [polypeptide binding]; other site
403833002166	dihydroorotase; Validated; Region: pyrC; PRK09357
403833002167	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
403833002168	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
403833002169	active site
403833002170	Uncharacterized protein family (UPF0150); Region: UPF0150; cl00691
403833002171	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
403833002172	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
403833002173	Walker A/P-loop; other site
403833002174	ATP binding site [chemical binding]; other site
403833002175	Q-loop/lid; other site
403833002176	ABC transporter signature motif; other site
403833002177	Walker B; other site
403833002178	D-loop; other site
403833002179	H-loop/switch region; other site
403833002180	Predicted transcriptional regulators [Transcription]; Region: COG1725
403833002181	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
403833002182	DNA-binding site [nucleotide binding]; DNA binding site
403833002183	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
403833002184	ABC-2 type transporter; Region: ABC2_membrane; cl17235
403833002185	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
403833002186	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
403833002187	Walker A/P-loop; other site
403833002188	ATP binding site [chemical binding]; other site
403833002189	Q-loop/lid; other site
403833002190	ABC transporter signature motif; other site
403833002191	Walker B; other site
403833002192	D-loop; other site
403833002193	H-loop/switch region; other site
403833002194	radical SAM/SPASM domain Clo7bot peptide maturase; Region: rSAM_Clo7bot; TIGR04334
403833002195	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
403833002196	FeS/SAM binding site; other site
403833002197	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
403833002198	Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641
403833002199	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
403833002200	FeS/SAM binding site; other site
403833002201	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
403833002202	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
403833002203	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
403833002204	Walker A/P-loop; other site
403833002205	ATP binding site [chemical binding]; other site
403833002206	Q-loop/lid; other site
403833002207	ABC transporter signature motif; other site
403833002208	Walker B; other site
403833002209	D-loop; other site
403833002210	H-loop/switch region; other site
403833002211	Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368
403833002212	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
403833002213	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
403833002214	Walker A/P-loop; other site
403833002215	ATP binding site [chemical binding]; other site
403833002216	Q-loop/lid; other site
403833002217	ABC transporter signature motif; other site
403833002218	Walker B; other site
403833002219	D-loop; other site
403833002220	H-loop/switch region; other site
403833002221	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
403833002222	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
403833002223	Cys-rich peptide radical SAM maturase CcpM; Region: rSAM_ocin_clost; TIGR04068
403833002224	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
403833002225	FeS/SAM binding site; other site
403833002226	transposase; Provisional; Region: PRK06526
403833002227	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
403833002228	Walker A motif; other site
403833002229	ATP binding site [chemical binding]; other site
403833002230	Walker B motif; other site
403833002231	Helix-turn-helix domain; Region: HTH_38; pfam13936
403833002232	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
403833002233	Integrase core domain; Region: rve; pfam00665
403833002234	Radical SAM superfamily; Region: Radical_SAM; pfam04055
403833002235	Cys-rich peptide radical SAM maturase CcpM; Region: rSAM_ocin_clost; TIGR04068
403833002236	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
403833002237	FeS/SAM binding site; other site
403833002238	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
403833002239	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
403833002240	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
403833002241	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
403833002242	Walker A/P-loop; other site
403833002243	ATP binding site [chemical binding]; other site
403833002244	Q-loop/lid; other site
403833002245	ABC transporter signature motif; other site
403833002246	Walker B; other site
403833002247	D-loop; other site
403833002248	H-loop/switch region; other site
403833002249	H+ Antiporter protein; Region: 2A0121; TIGR00900
403833002250	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
403833002251	putative substrate translocation pore; other site
403833002252	Major Facilitator Superfamily; Region: MFS_1; pfam07690
403833002253	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
403833002254	putative substrate translocation pore; other site
403833002255	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
403833002256	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
403833002257	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
403833002258	Walker A/P-loop; other site
403833002259	ATP binding site [chemical binding]; other site
403833002260	Q-loop/lid; other site
403833002261	ABC transporter signature motif; other site
403833002262	Walker B; other site
403833002263	D-loop; other site
403833002264	H-loop/switch region; other site
403833002265	Cache domain; Region: Cache_1; pfam02743
403833002266	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
403833002267	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
403833002268	dimerization interface [polypeptide binding]; other site
403833002269	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
403833002270	dimer interface [polypeptide binding]; other site
403833002271	putative CheW interface [polypeptide binding]; other site
403833002272	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
403833002273	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
403833002274	flavoprotein, HI0933 family; Region: TIGR00275
403833002275	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
403833002276	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
403833002277	dimer interface [polypeptide binding]; other site
403833002278	putative CheW interface [polypeptide binding]; other site
403833002279	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
403833002280	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
403833002281	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
403833002282	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
403833002283	ligand binding site [chemical binding]; other site
403833002284	hypothetical protein; Reviewed; Region: PRK12497
403833002285	aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase, C subunit; Region: gatC; TIGR00135
403833002286	N-glycosylase/DNA lyase; Provisional; Region: PRK01229
403833002287	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
403833002288	minor groove reading motif; other site
403833002289	helix-hairpin-helix signature motif; other site
403833002290	active site
403833002291	Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993
403833002292	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
403833002293	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
403833002294	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
403833002295	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
403833002296	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
403833002297	23S rRNA binding site [nucleotide binding]; other site
403833002298	L21 binding site [polypeptide binding]; other site
403833002299	L13 binding site [polypeptide binding]; other site
403833002300	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
403833002301	ligand-binding site [chemical binding]; other site
403833002302	sulfate adenylyltransferase; Reviewed; Region: sat; PRK04149
403833002303	ATP-sulfurylase; Region: ATPS; cd00517
403833002304	active site
403833002305	HXXH motif; other site
403833002306	flexible loop; other site
403833002307	Uncharacterized family 2; belongs to a superfamily containing transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this family was previously known as part of DUF156; Region: CsoR-like_DUF156_2; cd10159
403833002308	putative homotetramer interface [polypeptide binding]; other site
403833002309	putative homodimer interface [polypeptide binding]; other site
403833002310	putative allosteric switch controlling residues; other site
403833002311	putative metal binding site [ion binding]; other site
403833002312	putative homodimer-homodimer interface [polypeptide binding]; other site
403833002313	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
403833002314	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
403833002315	metal-binding site [ion binding]
403833002316	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
403833002317	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
403833002318	motif II; other site
403833002319	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
403833002320	metal-binding site [ion binding]
403833002321	Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597
403833002322	Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781
403833002323	Diacylglycerol kinase accessory domain; Region: DAGK_acc; cl02440
403833002324	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
403833002325	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833002326	dimer interface [polypeptide binding]; other site
403833002327	conserved gate region; other site
403833002328	putative PBP binding loops; other site
403833002329	ABC-ATPase subunit interface; other site
403833002330	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833002331	dimer interface [polypeptide binding]; other site
403833002332	putative PBP binding loops; other site
403833002333	ABC-ATPase subunit interface; other site
403833002334	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
403833002335	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
403833002336	N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789
403833002337	active site
403833002338	catalytic site [active]
403833002339	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872
403833002340	Glycosyl hydrolases family 38 C-terminal domain; Region: Glyco_hydro_38C; pfam07748
403833002341	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
403833002342	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
403833002343	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
403833002344	4Fe-4S binding domain; Region: Fer4; pfam00037
403833002345	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
403833002346	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
403833002347	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
403833002348	SLBB domain; Region: SLBB; pfam10531
403833002349	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
403833002350	4Fe-4S binding domain; Region: Fer4; pfam00037
403833002351	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
403833002352	4Fe-4S binding domain; Region: Fer4; pfam00037
403833002353	Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980
403833002354	[2Fe-2S] cluster binding site [ion binding]; other site
403833002355	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
403833002356	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
403833002357	putative dimer interface [polypeptide binding]; other site
403833002358	[2Fe-2S] cluster binding site [ion binding]; other site
403833002359	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
403833002360	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
403833002361	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
403833002362	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
403833002363	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
403833002364	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
403833002365	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565
403833002366	NAD(P) binding site [chemical binding]; other site
403833002367	active site
403833002368	Thioredoxin domain; Region: Thioredoxin_3; pfam13192
403833002369	Predicted permeases [General function prediction only]; Region: COG0701
403833002370	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
403833002371	propionate/acetate kinase; Provisional; Region: PRK12379
403833002372	Homoserine O-succinyltransferase; Region: HTS; pfam04204
403833002373	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
403833002374	proposed active site lysine [active]
403833002375	conserved cys residue [active]
403833002376	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
403833002377	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
403833002378	homodimer interface [polypeptide binding]; other site
403833002379	substrate-cofactor binding pocket; other site
403833002380	pyridoxal 5'-phosphate binding site [chemical binding]; other site
403833002381	catalytic residue [active]
403833002382	lipoprotein signal peptidase; Provisional; Region: PRK14787
403833002383	Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252
403833002384	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
403833002385	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
403833002386	RNA binding surface [nucleotide binding]; other site
403833002387	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
403833002388	active site
403833002389	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
403833002390	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
403833002391	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
403833002392	Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706
403833002393	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
403833002394	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
403833002395	putative active site [active]
403833002396	M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659
403833002397	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
403833002398	oligomer interface [polypeptide binding]; other site
403833002399	putative active site [active]
403833002400	metal binding site [ion binding]; metal-binding site
403833002401	F0F1-type ATP synthase, epsilon subunit (mitochondrial delta subunit) [Energy production and conversion]; Region: AtpC; COG0355
403833002402	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
403833002403	gamma subunit interface [polypeptide binding]; other site
403833002404	epsilon subunit interface [polypeptide binding]; other site
403833002405	LBP interface [polypeptide binding]; other site
403833002406	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
403833002407	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
403833002408	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
403833002409	alpha subunit interaction interface [polypeptide binding]; other site
403833002410	Walker A motif; other site
403833002411	ATP binding site [chemical binding]; other site
403833002412	Walker B motif; other site
403833002413	inhibitor binding site; inhibition site
403833002414	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
403833002415	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
403833002416	core domain interface [polypeptide binding]; other site
403833002417	delta subunit interface [polypeptide binding]; other site
403833002418	epsilon subunit interface [polypeptide binding]; other site
403833002419	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
403833002420	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
403833002421	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
403833002422	beta subunit interaction interface [polypeptide binding]; other site
403833002423	Walker A motif; other site
403833002424	ATP binding site [chemical binding]; other site
403833002425	Walker B motif; other site
403833002426	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
403833002427	F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210
403833002428	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
403833002429	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
403833002430	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
403833002431	F0F1 ATP synthase subunit C; Provisional; Region: PRK13471
403833002432	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
403833002433	Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046
403833002434	PrcB C-terminal; Region: PrcB_C; pfam14343
403833002435	Peptidase S8 family domain in Fervidolysin; Region: Peptidases_S8_Fervidolysin_like; cd07485
403833002436	active site
403833002437	catalytic triad [active]
403833002438	Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620
403833002439	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
403833002440	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
403833002441	Probable transposase; Region: OrfB_IS605; pfam01385
403833002442	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
403833002443	N-ethylammeline chlorohydrolase; Provisional; Region: PRK06038
403833002444	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
403833002445	active site
403833002446	putative substrate binding pocket [chemical binding]; other site
403833002447	NFRKB Winged Helix-like; Region: NFRKB_winged; pfam14465
403833002448	Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242
403833002449	Ribosomal protein L17 [Translation, ribosomal structure and biogenesis]; Region: RplQ; COG0203
403833002450	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
403833002451	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
403833002452	alphaNTD homodimer interface [polypeptide binding]; other site
403833002453	alphaNTD - beta interaction site [polypeptide binding]; other site
403833002454	alphaNTD - beta' interaction site [polypeptide binding]; other site
403833002455	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
403833002456	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
403833002457	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
403833002458	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
403833002459	RNA binding surface [nucleotide binding]; other site
403833002460	30S ribosomal protein S11; Validated; Region: PRK05309
403833002461	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
403833002462	30S ribosomal protein S13; Region: bact_S13; TIGR03631
403833002463	Ribosomal protein L36; Region: Ribosomal_L36; pfam00444
403833002464	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
403833002465	rRNA binding site [nucleotide binding]; other site
403833002466	predicted 30S ribosome binding site; other site
403833002467	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
403833002468	active site
403833002469	adenylate kinase; Reviewed; Region: adk; PRK00279
403833002470	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
403833002471	AMP-binding site [chemical binding]; other site
403833002472	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
403833002473	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
403833002474	SecY translocase; Region: SecY; pfam00344
403833002475	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
403833002476	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
403833002477	23S rRNA binding site [nucleotide binding]; other site
403833002478	ribosomal protein S5, bacterial/organelle type; Region: rpsE_bact; TIGR01021
403833002479	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
403833002480	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
403833002481	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
403833002482	5S rRNA interface [nucleotide binding]; other site
403833002483	L27 interface [polypeptide binding]; other site
403833002484	23S rRNA interface [nucleotide binding]; other site
403833002485	L5 interface [polypeptide binding]; other site
403833002486	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
403833002487	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
403833002488	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
403833002489	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
403833002490	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061
403833002491	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
403833002492	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
403833002493	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
403833002494	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
403833002495	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
403833002496	RNA binding site [nucleotide binding]; other site
403833002497	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
403833002498	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
403833002499	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
403833002500	L23 interface [polypeptide binding]; other site
403833002501	signal recognition particle (SRP54) interaction site; other site
403833002502	trigger factor interaction site; other site
403833002503	23S rRNA interface [nucleotide binding]; other site
403833002504	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
403833002505	23S rRNA interface [nucleotide binding]; other site
403833002506	5S rRNA interface [nucleotide binding]; other site
403833002507	putative antibiotic binding site [chemical binding]; other site
403833002508	L25 interface [polypeptide binding]; other site
403833002509	L27 interface [polypeptide binding]; other site
403833002510	ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009
403833002511	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
403833002512	G-X-X-G motif; other site
403833002513	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
403833002514	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
403833002515	putative translocon binding site; other site
403833002516	protein-rRNA interface [nucleotide binding]; other site
403833002517	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
403833002518	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
403833002519	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
403833002520	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
403833002521	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
403833002522	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
403833002523	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
403833002524	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
403833002525	elongation factor Tu; Reviewed; Region: PRK00049
403833002526	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
403833002527	G1 box; other site
403833002528	GEF interaction site [polypeptide binding]; other site
403833002529	GTP/Mg2+ binding site [chemical binding]; other site
403833002530	Switch I region; other site
403833002531	G2 box; other site
403833002532	G3 box; other site
403833002533	Switch II region; other site
403833002534	G4 box; other site
403833002535	G5 box; other site
403833002536	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
403833002537	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
403833002538	Antibiotic Binding Site [chemical binding]; other site
403833002539	elongation factor G; Reviewed; Region: PRK00007
403833002540	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
403833002541	G1 box; other site
403833002542	putative GEF interaction site [polypeptide binding]; other site
403833002543	GTP/Mg2+ binding site [chemical binding]; other site
403833002544	Switch I region; other site
403833002545	G2 box; other site
403833002546	G3 box; other site
403833002547	Switch II region; other site
403833002548	G4 box; other site
403833002549	G5 box; other site
403833002550	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
403833002551	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
403833002552	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
403833002553	30S ribosomal protein S7; Validated; Region: PRK05302
403833002554	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
403833002555	S17 interaction site [polypeptide binding]; other site
403833002556	S8 interaction site; other site
403833002557	16S rRNA interaction site [nucleotide binding]; other site
403833002558	streptomycin interaction site [chemical binding]; other site
403833002559	23S rRNA interaction site [nucleotide binding]; other site
403833002560	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
403833002561	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
403833002562	Part of AAA domain; Region: AAA_19; pfam13245
403833002563	Family description; Region: UvrD_C_2; pfam13538
403833002564	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
403833002565	RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393
403833002566	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
403833002567	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
403833002568	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
403833002569	DNA binding residues [nucleotide binding]
403833002570	RRXRR protein; Region: RRXRR; pfam14239
403833002571	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
403833002572	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
403833002573	active site
403833002574	DNA primase, catalytic core; Region: dnaG; TIGR01391
403833002575	CHC2 zinc finger; Region: zf-CHC2; pfam01807
403833002576	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
403833002577	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
403833002578	active site
403833002579	metal binding site [ion binding]; metal-binding site
403833002580	interdomain interaction site; other site
403833002581	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
403833002582	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
403833002583	23S rRNA interface [nucleotide binding]; other site
403833002584	L3 interface [polypeptide binding]; other site
403833002585	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
403833002586	Predicted membrane protein [Function unknown]; Region: COG3601
403833002587	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
403833002588	Protein of unknown function (DUF464); Region: DUF464; cl01080
403833002589	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
403833002590	Transglycosylase; Region: Transgly; pfam00912
403833002591	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
403833002592	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
403833002593	hypothetical protein; Validated; Region: PRK00110
403833002594	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
403833002595	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
403833002596	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
403833002597	S-adenosylmethionine binding site [chemical binding]; other site
403833002598	Predicted translation initiation factor 2B subunit, eIF-2B alpha/beta/delta family [Translation, ribosomal structure and biogenesis]; Region: COG0182
403833002599	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
403833002600	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
403833002601	active site
403833002602	metal binding site [ion binding]; metal-binding site
403833002603	homotetramer interface [polypeptide binding]; other site
403833002604	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
403833002605	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
403833002606	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
403833002607	FtsX-like permease family; Region: FtsX; pfam02687
403833002608	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
403833002609	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
403833002610	Walker A/P-loop; other site
403833002611	ATP binding site [chemical binding]; other site
403833002612	Q-loop/lid; other site
403833002613	ABC transporter signature motif; other site
403833002614	Walker B; other site
403833002615	D-loop; other site
403833002616	H-loop/switch region; other site
403833002617	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
403833002618	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
403833002619	HlyD family secretion protein; Region: HlyD_3; pfam13437
403833002620	Outer membrane efflux protein; Region: OEP; pfam02321
403833002621	Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538
403833002622	FtsH Extracellular; Region: FtsH_ext; pfam06480
403833002623	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
403833002624	AAA ATPase domain; Region: AAA_16; pfam13191
403833002625	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
403833002626	Walker A motif; other site
403833002627	ATP binding site [chemical binding]; other site
403833002628	Walker B motif; other site
403833002629	arginine finger; other site
403833002630	Peptidase family M41; Region: Peptidase_M41; pfam01434
403833002631	Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148
403833002632	putative homodimer interface [polypeptide binding]; other site
403833002633	putative homotetramer interface [polypeptide binding]; other site
403833002634	putative allosteric switch controlling residues; other site
403833002635	putative metal binding site [ion binding]; other site
403833002636	putative homodimer-homodimer interface [polypeptide binding]; other site
403833002637	C-terminal peptidase (prc); Region: prc; TIGR00225
403833002638	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
403833002639	protein binding site [polypeptide binding]; other site
403833002640	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
403833002641	Catalytic dyad [active]
403833002642	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
403833002643	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
403833002644	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
403833002645	Melibiase; Region: Melibiase; pfam02065
403833002646	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
403833002647	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833002648	dimer interface [polypeptide binding]; other site
403833002649	conserved gate region; other site
403833002650	putative PBP binding loops; other site
403833002651	ABC-ATPase subunit interface; other site
403833002652	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
403833002653	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
403833002654	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833002655	putative PBP binding loops; other site
403833002656	dimer interface [polypeptide binding]; other site
403833002657	ABC-ATPase subunit interface; other site
403833002658	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
403833002659	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
403833002660	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
403833002661	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
403833002662	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
403833002663	Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533
403833002664	galactokinase; Provisional; Region: PRK05322
403833002665	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
403833002666	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
403833002667	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
403833002668	Galactose-1-phosphate uridylyltransferase [Energy production and conversion]; Region: GalT; COG1085
403833002669	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
403833002670	dimer interface [polypeptide binding]; other site
403833002671	active site
403833002672	Transcriptional regulators [Transcription]; Region: PurR; COG1609
403833002673	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
403833002674	DNA binding site [nucleotide binding]
403833002675	domain linker motif; other site
403833002676	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
403833002677	dimerization interface [polypeptide binding]; other site
403833002678	ligand binding site [chemical binding]; other site
403833002679	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
403833002680	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
403833002681	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
403833002682	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
403833002683	active site
403833002684	dimer interface [polypeptide binding]; other site
403833002685	motif 1; other site
403833002686	motif 2; other site
403833002687	motif 3; other site
403833002688	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
403833002689	anticodon binding site; other site
403833002690	peptide chain release factor 2; Provisional; Region: PRK05589
403833002691	This domain is found in peptide chain release factors; Region: PCRF; smart00937
403833002692	RF-1 domain; Region: RF-1; pfam00472
403833002693	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
403833002694	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
403833002695	dimerization interface [polypeptide binding]; other site
403833002696	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
403833002697	dimer interface [polypeptide binding]; other site
403833002698	putative CheW interface [polypeptide binding]; other site
403833002699	voltage-dependent potassium channel beta subunit, animal; Region: Kv_beta; TIGR01293
403833002700	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
403833002701	active site
403833002702	catalytic tetrad [active]
403833002703	dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350
403833002704	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
403833002705	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
403833002706	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
403833002707	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
403833002708	ribosome biogenesis GTPase YqeH; Region: GTPase_YqeH; TIGR03597
403833002709	Circularly permuted YqeH GTPase; Region: YqeH; cd01855
403833002710	GTP/Mg2+ binding site [chemical binding]; other site
403833002711	G4 box; other site
403833002712	G5 box; other site
403833002713	G1 box; other site
403833002714	Switch I region; other site
403833002715	G2 box; other site
403833002716	G3 box; other site
403833002717	Switch II region; other site
403833002718	propanediol utilization phosphotransacylase; Provisional; Region: PRK15070
403833002719	Propanediol utilisation protein PduL; Region: PduL; pfam06130
403833002720	Propanediol utilisation protein PduL; Region: PduL; pfam06130
403833002721	ribosome biogenesis GTP-binding protein YlqF; Region: GTPase_YlqF; TIGR03596
403833002722	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
403833002723	GTP/Mg2+ binding site [chemical binding]; other site
403833002724	G4 box; other site
403833002725	G5 box; other site
403833002726	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
403833002727	G1 box; other site
403833002728	G1 box; other site
403833002729	GTP/Mg2+ binding site [chemical binding]; other site
403833002730	Switch I region; other site
403833002731	G2 box; other site
403833002732	G2 box; other site
403833002733	Switch I region; other site
403833002734	G3 box; other site
403833002735	G3 box; other site
403833002736	Switch II region; other site
403833002737	Switch II region; other site
403833002738	G5 box; other site
403833002739	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
403833002740	PhoH-like protein; Region: PhoH; pfam02562
403833002741	7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698
403833002742	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
403833002743	Zn2+ binding site [ion binding]; other site
403833002744	Mg2+ binding site [ion binding]; other site
403833002745	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
403833002746	Uncharacterized conserved protein [Function unknown]; Region: COG4198
403833002747	Protein of unknown function (DUF1015); Region: DUF1015; pfam06245
403833002748	Protein of unknown function (DUF402); Region: DUF402; cl00979
403833002749	PspC domain; Region: PspC; pfam04024
403833002750	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
403833002751	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
403833002752	dimerization interface [polypeptide binding]; other site
403833002753	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
403833002754	dimer interface [polypeptide binding]; other site
403833002755	phosphorylation site [posttranslational modification]
403833002756	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
403833002757	ATP binding site [chemical binding]; other site
403833002758	Mg2+ binding site [ion binding]; other site
403833002759	G-X-G motif; other site
403833002760	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
403833002761	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
403833002762	active site
403833002763	phosphorylation site [posttranslational modification]
403833002764	intermolecular recognition site; other site
403833002765	dimerization interface [polypeptide binding]; other site
403833002766	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
403833002767	DNA binding site [nucleotide binding]
403833002768	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660
403833002769	Dolichol kinase [Lipid metabolism]; Region: SEC59; COG0170
403833002770	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
403833002771	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
403833002772	NAD binding site [chemical binding]; other site
403833002773	sugar binding site [chemical binding]; other site
403833002774	divalent metal binding site [ion binding]; other site
403833002775	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
403833002776	dimer interface [polypeptide binding]; other site
403833002777	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
403833002778	Glucuronate isomerase; Region: UxaC; pfam02614
403833002779	Helix-turn-helix domain; Region: HTH_20; pfam12840
403833002780	putative DNA binding site [nucleotide binding]; other site
403833002781	putative Zn2+ binding site [ion binding]; other site
403833002782	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
403833002783	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
403833002784	nucleotide binding site [chemical binding]; other site
403833002785	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
403833002786	Predicted RNA-binding protein homologous to eukaryotic snRNP [Transcription]; Region: COG1293
403833002787	Domain of unknown function (DUF814); Region: DUF814; pfam05670
403833002788	ABC transporter substrate binding protein; Region: ABC_sub_bind; cl17301
403833002789	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
403833002790	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
403833002791	Zn2+ binding site [ion binding]; other site
403833002792	Mg2+ binding site [ion binding]; other site
403833002793	Ferritin-CCC1, N-terminal ferritin-like diiron-binding domain; Region: Ferritin_CCC1_N; cd01044
403833002794	diiron binding motif [ion binding]; other site
403833002795	CCC1-related domain of ferritin; Region: Ferritin_CCC1_C; cd02431
403833002796	Cache domain; Region: Cache_1; pfam02743
403833002797	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
403833002798	dimerization interface [polypeptide binding]; other site
403833002799	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
403833002800	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
403833002801	dimer interface [polypeptide binding]; other site
403833002802	putative CheW interface [polypeptide binding]; other site
403833002803	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
403833002804	SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043
403833002805	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
403833002806	nucleotide binding region [chemical binding]; other site
403833002807	ATP-binding site [chemical binding]; other site
403833002808	peptide chain release factor 2; Validated; Region: prfB; PRK00578
403833002809	This domain is found in peptide chain release factors; Region: PCRF; smart00937
403833002810	RF-1 domain; Region: RF-1; pfam00472
403833002811	MraW methylase family; Region: Methyltransf_5; cl17771
403833002812	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
403833002813	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
403833002814	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
403833002815	PASTA domain of PBP2x-like proteins, second repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_2; cd06575
403833002816	DNA polymerase III, delta subunit [DNA replication, recombination, and repair]; Region: HolA; COG1466
403833002817	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
403833002818	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
403833002819	dimer interface [polypeptide binding]; other site
403833002820	phosphorylation site [posttranslational modification]
403833002821	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
403833002822	ATP binding site [chemical binding]; other site
403833002823	Mg2+ binding site [ion binding]; other site
403833002824	G-X-G motif; other site
403833002825	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
403833002826	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
403833002827	active site
403833002828	FMN binding site [chemical binding]; other site
403833002829	substrate binding site [chemical binding]; other site
403833002830	homotetramer interface [polypeptide binding]; other site
403833002831	catalytic residue [active]
403833002832	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
403833002833	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
403833002834	Ligand Binding Site [chemical binding]; other site
403833002835	FtsH Extracellular; Region: FtsH_ext; pfam06480
403833002836	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
403833002837	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
403833002838	Walker A motif; other site
403833002839	ATP binding site [chemical binding]; other site
403833002840	Walker B motif; other site
403833002841	arginine finger; other site
403833002842	Peptidase family M41; Region: Peptidase_M41; pfam01434
403833002843	Predicted thioesterase [General function prediction only]; Region: COG5496
403833002844	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
403833002845	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
403833002846	active site
403833002847	phosphorylation site [posttranslational modification]
403833002848	intermolecular recognition site; other site
403833002849	dimerization interface [polypeptide binding]; other site
403833002850	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
403833002851	DNA binding site [nucleotide binding]
403833002852	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
403833002853	dimer interface [polypeptide binding]; other site
403833002854	phosphorylation site [posttranslational modification]
403833002855	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
403833002856	ATP binding site [chemical binding]; other site
403833002857	Mg2+ binding site [ion binding]; other site
403833002858	G-X-G motif; other site
403833002859	Thymidine phosphorylase [Nucleotide transport and metabolism]; Region: DeoA; COG0213
403833002860	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
403833002861	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
403833002862	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
403833002863	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
403833002864	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
403833002865	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
403833002866	elongation factor G; Reviewed; Region: PRK12740
403833002867	G1 box; other site
403833002868	GTP/Mg2+ binding site [chemical binding]; other site
403833002869	G2 box; other site
403833002870	Switch I region; other site
403833002871	G3 box; other site
403833002872	Switch II region; other site
403833002873	G4 box; other site
403833002874	G5 box; other site
403833002875	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
403833002876	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
403833002877	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
403833002878	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
403833002879	Protein of unknown function (DUF503); Region: DUF503; pfam04456
403833002880	Predicted HD superfamily hydrolase involved in NAD metabolism [Coenzyme metabolism]; Region: COG1713
403833002881	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
403833002882	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
403833002883	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
403833002884	Peptidase family M23; Region: Peptidase_M23; pfam01551
403833002885	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
403833002886	putative oxidoreductase; Provisional; Region: PRK13984
403833002887	4Fe-4S binding domain; Region: Fer4; pfam00037
403833002888	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
403833002889	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
403833002890	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
403833002891	NADH dehydrogenase subunit D; Validated; Region: PRK06075
403833002892	Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; pfam00329
403833002893	NADH dehydrogenase subunit B; Validated; Region: PRK06411
403833002894	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
403833002895	NADH dehydrogenase; Region: NADHdh; cl00469
403833002896	NADH dehydrogenase subunit M; Validated; Region: PRK08668
403833002897	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
403833002898	NADH dehydrogenase subunit N; Validated; Region: PRK08377
403833002899	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
403833002900	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK07375
403833002901	putative monovalent cation/H+ antiporter subunit B; Reviewed; Region: PRK12567
403833002902	hypothetical protein; Provisional; Region: PRK08378
403833002903	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
403833002904	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK12599
403833002905	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651
403833002906	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cl00470
403833002907	active site
403833002908	catalytic tetrad [active]
403833002909	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
403833002910	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
403833002911	substrate binding site [chemical binding]; other site
403833002912	ATP binding site [chemical binding]; other site
403833002913	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
403833002914	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
403833002915	dimer interface [polypeptide binding]; other site
403833002916	pyridoxal binding site [chemical binding]; other site
403833002917	ATP binding site [chemical binding]; other site
403833002918	Amidinotransferase; Region: Amidinotransf; cl12043
403833002919	Predicted GTPase [General function prediction only]; Region: COG2403
403833002920	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
403833002921	Cell envelope-related transcriptional attenuator domain; Region: LytR_cpsA_psr; cl00581
403833002922	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
403833002923	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
403833002924	FtsX-like permease family; Region: FtsX; pfam02687
403833002925	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
403833002926	active site
403833002927	multimer interface [polypeptide binding]; other site
403833002928	ADP-glucose pyrophosphorylase [Carbohydrate transport and metabolism]; Region: GlgC; COG0448
403833002929	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
403833002930	ligand binding site; other site
403833002931	oligomer interface; other site
403833002932	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
403833002933	dimer interface [polypeptide binding]; other site
403833002934	N-terminal domain interface [polypeptide binding]; other site
403833002935	sulfate 1 binding site; other site
403833002936	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK05293
403833002937	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
403833002938	ligand binding site; other site
403833002939	oligomer interface; other site
403833002940	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
403833002941	dimer interface [polypeptide binding]; other site
403833002942	N-terminal domain interface [polypeptide binding]; other site
403833002943	sulfate 1 binding site; other site
403833002944	Biotin synthase-related enzyme [General function prediction only]; Region: COG2516
403833002945	Glycerophosphodiester phosphodiesterase domain of Thermotoga maritime and similar proteins; Region: GDPD_TmGDE_like; cd08568
403833002946	Glycerophosphoryl diester phosphodiesterase family; Region: GDPD; pfam03009
403833002947	putative active site [active]
403833002948	catalytic site [active]
403833002949	putative metal binding site [ion binding]; other site
403833002950	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
403833002951	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
403833002952	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
403833002953	ligand binding site [chemical binding]; other site
403833002954	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
403833002955	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
403833002956	Walker A/P-loop; other site
403833002957	ATP binding site [chemical binding]; other site
403833002958	Q-loop/lid; other site
403833002959	ABC transporter signature motif; other site
403833002960	Walker B; other site
403833002961	D-loop; other site
403833002962	H-loop/switch region; other site
403833002963	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
403833002964	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
403833002965	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
403833002966	TM-ABC transporter signature motif; other site
403833002967	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
403833002968	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
403833002969	TM-ABC transporter signature motif; other site
403833002970	Transcriptional regulators [Transcription]; Region: PurR; COG1609
403833002971	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
403833002972	DNA binding site [nucleotide binding]
403833002973	domain linker motif; other site
403833002974	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
403833002975	dimerization interface [polypeptide binding]; other site
403833002976	ligand binding site [chemical binding]; other site
403833002977	D-ribose pyranase; Provisional; Region: PRK11797
403833002978	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
403833002979	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
403833002980	Walker A/P-loop; other site
403833002981	ATP binding site [chemical binding]; other site
403833002982	Q-loop/lid; other site
403833002983	ABC transporter signature motif; other site
403833002984	Walker B; other site
403833002985	D-loop; other site
403833002986	H-loop/switch region; other site
403833002987	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
403833002988	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
403833002989	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
403833002990	TM-ABC transporter signature motif; other site
403833002991	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
403833002992	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
403833002993	ligand binding site [chemical binding]; other site
403833002994	dimerization interface [polypeptide binding]; other site
403833002995	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
403833002996	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
403833002997	substrate binding site [chemical binding]; other site
403833002998	dimer interface [polypeptide binding]; other site
403833002999	ATP binding site [chemical binding]; other site
403833003000	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
403833003001	Major Facilitator Superfamily; Region: MFS_1; pfam07690
403833003002	putative substrate translocation pore; other site
403833003003	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
403833003004	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
403833003005	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
403833003006	Bacterial sugar transferase; Region: Bac_transf; pfam02397
403833003007	CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439
403833003008	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
403833003009	DXD motif; other site
403833003010	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
403833003011	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
403833003012	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
403833003013	active site
403833003014	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
403833003015	homodimer interface [polypeptide binding]; other site
403833003016	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
403833003017	4-alpha-L-fucosyltransferase; Provisional; Region: PRK02797
403833003018	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
403833003019	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
403833003020	trimer interface [polypeptide binding]; other site
403833003021	active site
403833003022	substrate binding site [chemical binding]; other site
403833003023	CoA binding site [chemical binding]; other site
403833003024	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
403833003025	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
403833003026	inhibitor-cofactor binding pocket; inhibition site
403833003027	pyridoxal 5'-phosphate binding site [chemical binding]; other site
403833003028	catalytic residue [active]
403833003029	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
403833003030	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
403833003031	substrate binding site; other site
403833003032	tetramer interface; other site
403833003033	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
403833003034	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
403833003035	NAD binding site [chemical binding]; other site
403833003036	substrate binding site [chemical binding]; other site
403833003037	homodimer interface [polypeptide binding]; other site
403833003038	active site
403833003039	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
403833003040	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
403833003041	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
403833003042	Coenzyme A binding pocket [chemical binding]; other site
403833003043	PHP domain; Region: PHP; pfam02811
403833003044	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
403833003045	Chain length determinant protein; Region: Wzz; pfam02706
403833003046	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
403833003047	capsular exopolysaccharide family; Region: eps_fam; TIGR01007
403833003048	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
403833003049	Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206
403833003050	Chain length determinant protein; Region: Wzz; cl15801
403833003051	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
403833003052	ATP-dependent nuclease, subunit B [DNA replication, recombination, and repair]; Region: AddB; COG3857
403833003053	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
403833003054	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
403833003055	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
403833003056	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
403833003057	ATP binding site [chemical binding]; other site
403833003058	Mg++ binding site [ion binding]; other site
403833003059	motif III; other site
403833003060	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
403833003061	nucleotide binding region [chemical binding]; other site
403833003062	ATP-binding site [chemical binding]; other site
403833003063	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
403833003064	RNA binding site [nucleotide binding]; other site
403833003065	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
403833003066	Malic enzyme, N-terminal domain; Region: malic; pfam00390
403833003067	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
403833003068	putative NAD(P) binding site [chemical binding]; other site
403833003069	Tartrate dehydratase beta subunit/Fumarate hydratase class I, C-terminal domain [Energy production and conversion]; Region: FumA; COG1838
403833003070	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
403833003071	Transcriptional regulators [Transcription]; Region: PurR; COG1609
403833003072	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
403833003073	DNA binding site [nucleotide binding]
403833003074	domain linker motif; other site
403833003075	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
403833003076	ligand binding site [chemical binding]; other site
403833003077	dimerization interface [polypeptide binding]; other site
403833003078	Putative carbohydrate binding domain; Region: CBM_X; pfam06204
403833003079	Glycoside hydrolase family 94 N-terminal-like domain of uncharacterized function; Region: GH94N_like_4; cd11751
403833003080	Protein of unknown function, DUF608; Region: DUF608; pfam04685
403833003081	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
403833003082	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
403833003083	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833003084	dimer interface [polypeptide binding]; other site
403833003085	conserved gate region; other site
403833003086	putative PBP binding loops; other site
403833003087	ABC-ATPase subunit interface; other site
403833003088	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
403833003089	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
403833003090	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833003091	dimer interface [polypeptide binding]; other site
403833003092	conserved gate region; other site
403833003093	putative PBP binding loops; other site
403833003094	ABC-ATPase subunit interface; other site
403833003095	Predicted esterase [General function prediction only]; Region: COG0627
403833003096	S-formylglutathione hydrolase; Region: PLN02442
403833003097	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
403833003098	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
403833003099	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
403833003100	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
403833003101	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
403833003102	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
403833003103	inhibitor-cofactor binding pocket; inhibition site
403833003104	pyridoxal 5'-phosphate binding site [chemical binding]; other site
403833003105	catalytic residue [active]
403833003106	UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677
403833003107	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
403833003108	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
403833003109	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
403833003110	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
403833003111	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
403833003112	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
403833003113	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
403833003114	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
403833003115	active site
403833003116	isoaspartyl dipeptidase; Provisional; Region: PRK10657
403833003117	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
403833003118	active site
403833003119	FeoA domain; Region: FeoA; pfam04023
403833003120	FeoA domain; Region: FeoA; cl00838
403833003121	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
403833003122	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
403833003123	G1 box; other site
403833003124	GTP/Mg2+ binding site [chemical binding]; other site
403833003125	Switch I region; other site
403833003126	G2 box; other site
403833003127	G3 box; other site
403833003128	Switch II region; other site
403833003129	G4 box; other site
403833003130	Nucleoside recognition; Region: Gate; pfam07670
403833003131	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
403833003132	Nucleoside recognition; Region: Gate; pfam07670
403833003133	Yqey-like protein; Region: YqeY; pfam09424
403833003134	Putative Fe-S cluster; Region: FeS; cl17515
403833003135	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
403833003136	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815
403833003137	dimer interface [polypeptide binding]; other site
403833003138	active site
403833003139	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
403833003140	substrate binding site [chemical binding]; other site
403833003141	catalytic residue [active]
403833003142	replicative DNA helicase; Region: DnaB; TIGR00665
403833003143	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
403833003144	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
403833003145	Walker A motif; other site
403833003146	ATP binding site [chemical binding]; other site
403833003147	Walker B motif; other site
403833003148	DNA binding loops [nucleotide binding]
403833003149	ribonuclease R; Region: RNase_R; TIGR02063
403833003150	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
403833003151	RNB domain; Region: RNB; pfam00773
403833003152	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
403833003153	RNA binding site [nucleotide binding]; other site
403833003154	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
403833003155	FAD binding domain; Region: FAD_binding_4; pfam01565
403833003156	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
403833003157	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
403833003158	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
403833003159	motif II; other site
403833003160	bifunctional aspartate carbamoyltransferase catalytic subunit/aspartate carbamoyltransferase regulatory subunit; Provisional; Region: pyrB; PRK13376
403833003161	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
403833003162	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
403833003163	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
403833003164	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
403833003165	Anaerobic ribonucleoside-triphosphate reductase; Region: NRDD; pfam13597
403833003166	Class III ribonucleotide reductase; Region: RNR_III; cd01675
403833003167	effector binding site; other site
403833003168	active site
403833003169	Zn binding site [ion binding]; other site
403833003170	glycine loop; other site
403833003171	anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG2; TIGR02495
403833003172	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
403833003173	FeS/SAM binding site; other site
403833003174	Domain of unknown function (DUF2437); Region: DUF2437; pfam10370
403833003175	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
403833003176	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
403833003177	Uncharacterized conserved protein [Function unknown]; Region: COG3379
403833003178	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
403833003179	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
403833003180	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
403833003181	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
403833003182	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
403833003183	B12 binding site [chemical binding]; other site
403833003184	Uncharacterized conserved protein [Function unknown]; Region: COG4748
403833003185	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
403833003186	Uncharacterized conserved protein [Function unknown]; Region: COG3586
403833003187	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
403833003188	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
403833003189	dimer interface [polypeptide binding]; other site
403833003190	putative PBP binding regions; other site
403833003191	ABC-ATPase subunit  interface; other site
403833003192	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
403833003193	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
403833003194	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
403833003195	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
403833003196	intersubunit interface [polypeptide binding]; other site
403833003197	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
403833003198	metal binding site 2 [ion binding]; metal-binding site
403833003199	putative DNA binding helix; other site
403833003200	metal binding site 1 [ion binding]; metal-binding site
403833003201	dimer interface [polypeptide binding]; other site
403833003202	structural Zn2+ binding site [ion binding]; other site
403833003203	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474
403833003204	Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690
403833003205	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
403833003206	Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246
403833003207	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
403833003208	motif II; other site
403833003209	Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689
403833003210	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
403833003211	Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030
403833003212	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204
403833003213	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
403833003214	active site
403833003215	ADP/pyrophosphate binding site [chemical binding]; other site
403833003216	dimerization interface [polypeptide binding]; other site
403833003217	allosteric effector site; other site
403833003218	fructose-1,6-bisphosphate binding site; other site
403833003219	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
403833003220	DNA photolyase; Region: DNA_photolyase; pfam00875
403833003221	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
403833003222	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
403833003223	nucleotide binding pocket [chemical binding]; other site
403833003224	K-X-D-G motif; other site
403833003225	catalytic site [active]
403833003226	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
403833003227	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
403833003228	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
403833003229	Dimer interface [polypeptide binding]; other site
403833003230	BRCT sequence motif; other site
403833003231	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
403833003232	Cell division protein FtsA; Region: FtsA; smart00842
403833003233	Cell division protein FtsA; Region: FtsA; pfam14450
403833003234	recombination and DNA strand exchange inhibitor protein; Reviewed; Region: PRK00409
403833003235	MutS domain III; Region: MutS_III; pfam05192
403833003236	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
403833003237	Walker A/P-loop; other site
403833003238	ATP binding site [chemical binding]; other site
403833003239	Q-loop/lid; other site
403833003240	ABC transporter signature motif; other site
403833003241	Walker B; other site
403833003242	D-loop; other site
403833003243	H-loop/switch region; other site
403833003244	Smr domain; Region: Smr; pfam01713
403833003245	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
403833003246	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
403833003247	TPP-binding site; other site
403833003248	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
403833003249	PYR/PP interface [polypeptide binding]; other site
403833003250	dimer interface [polypeptide binding]; other site
403833003251	TPP binding site [chemical binding]; other site
403833003252	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
403833003253	NusB family; Region: NusB; pfam01029
403833003254	putative RNA binding site [nucleotide binding]; other site
403833003255	Asp23 family; Region: Asp23; pfam03780
403833003256	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
403833003257	MutS domain I; Region: MutS_I; pfam01624
403833003258	MutS domain III; Region: MutS_III; pfam05192
403833003259	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
403833003260	Walker A/P-loop; other site
403833003261	ATP binding site [chemical binding]; other site
403833003262	Q-loop/lid; other site
403833003263	ABC transporter signature motif; other site
403833003264	Walker B; other site
403833003265	D-loop; other site
403833003266	H-loop/switch region; other site
403833003267	Clp protease; Region: CLP_protease; pfam00574
403833003268	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
403833003269	oligomer interface [polypeptide binding]; other site
403833003270	active site residues [active]
403833003271	Domain of unknown function (DUF370); Region: DUF370; cl00898
403833003272	Exonuclease VII, large subunit; Region: Exonuc_VII_L; pfam02601
403833003273	Predicted methyltransferases [General function prediction only]; Region: COG0313
403833003274	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
403833003275	putative SAM binding site [chemical binding]; other site
403833003276	putative homodimer interface [polypeptide binding]; other site
403833003277	acyl carrier protein; Provisional; Region: acpP; PRK00982
403833003278	CTP synthetase; Validated; Region: pyrG; PRK05380
403833003279	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
403833003280	Catalytic site [active]
403833003281	active site
403833003282	UTP binding site [chemical binding]; other site
403833003283	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
403833003284	active site
403833003285	putative oxyanion hole; other site
403833003286	catalytic triad [active]
403833003287	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
403833003288	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
403833003289	N-acetyl-D-glucosamine binding site [chemical binding]; other site
403833003290	catalytic residue [active]
403833003291	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
403833003292	ATP phosphoribosyltransferase, regulatory subunit; Region: hisZ_biosyn_reg; TIGR00443
403833003293	motif 1; other site
403833003294	dimer interface [polypeptide binding]; other site
403833003295	active site
403833003296	motif 3; other site
403833003297	ATP phosphoribosyltransferase catalytic subunit; Reviewed; Region: hisG; PRK01686
403833003298	ATP phosphoribosyltransferase [Amino acid transport and metabolism]; Region: HisG; COG0040
403833003299	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
403833003300	histidinol dehydrogenase; Region: hisD; TIGR00069
403833003301	NAD binding site [chemical binding]; other site
403833003302	dimerization interface [polypeptide binding]; other site
403833003303	product binding site; other site
403833003304	substrate binding site [chemical binding]; other site
403833003305	zinc binding site [ion binding]; other site
403833003306	catalytic residues [active]
403833003307	imidazoleglycerol-phosphate dehydratase; Validated; Region: hisB; PRK00951
403833003308	putative active site pocket [active]
403833003309	4-fold oligomerization interface [polypeptide binding]; other site
403833003310	metal binding residues [ion binding]; metal-binding site
403833003311	3-fold/trimer interface [polypeptide binding]; other site
403833003312	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13143
403833003313	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
403833003314	putative active site [active]
403833003315	oxyanion strand; other site
403833003316	catalytic triad [active]
403833003317	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
403833003318	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
403833003319	catalytic residues [active]
403833003320	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
403833003321	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
403833003322	substrate binding site [chemical binding]; other site
403833003323	glutamase interaction surface [polypeptide binding]; other site
403833003324	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
403833003325	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
403833003326	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
403833003327	metal binding site [ion binding]; metal-binding site
403833003328	histidinol-phosphate aminotransferase; Provisional; Region: PRK03967
403833003329	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
403833003330	pyridoxal 5'-phosphate binding site [chemical binding]; other site
403833003331	homodimer interface [polypeptide binding]; other site
403833003332	catalytic residue [active]
403833003333	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
403833003334	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
403833003335	dimer interface [polypeptide binding]; other site
403833003336	active site
403833003337	metal binding site [ion binding]; metal-binding site
403833003338	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
403833003339	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
403833003340	FMN binding site [chemical binding]; other site
403833003341	substrate binding site [chemical binding]; other site
403833003342	putative catalytic residue [active]
403833003343	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
403833003344	Cation efflux family; Region: Cation_efflux; pfam01545
403833003345	GTPase CgtA; Reviewed; Region: obgE; PRK12297
403833003346	GTP1/OBG; Region: GTP1_OBG; pfam01018
403833003347	Obg GTPase; Region: Obg; cd01898
403833003348	G1 box; other site
403833003349	GTP/Mg2+ binding site [chemical binding]; other site
403833003350	Switch I region; other site
403833003351	G2 box; other site
403833003352	G3 box; other site
403833003353	Switch II region; other site
403833003354	G4 box; other site
403833003355	G5 box; other site
403833003356	Domain of unknown function (DUF1967); Region: DUF1967; pfam09269
403833003357	nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482
403833003358	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
403833003359	active site
403833003360	(T/H)XGH motif; other site
403833003361	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
403833003362	putative trimer interface [polypeptide binding]; other site
403833003363	putative CoA binding site [chemical binding]; other site
403833003364	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
403833003365	putative trimer interface [polypeptide binding]; other site
403833003366	putative active site [active]
403833003367	putative substrate binding site [chemical binding]; other site
403833003368	putative CoA binding site [chemical binding]; other site
403833003369	Formiminotransferase-cyclodeaminase; Region: FTCD_C; pfam04961
403833003370	H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452
403833003371	membrane-bound proton-translocating pyrophosphatase; Validated; Region: hppA; PRK00733
403833003372	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
403833003373	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
403833003374	NAD(P) binding site [chemical binding]; other site
403833003375	homotetramer interface [polypeptide binding]; other site
403833003376	homodimer interface [polypeptide binding]; other site
403833003377	active site
403833003378	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
403833003379	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
403833003380	putative enoyl-[acyl-carrier-protein] reductase II; Region: enACPred_II; TIGR03151
403833003381	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
403833003382	FMN binding site [chemical binding]; other site
403833003383	substrate binding site [chemical binding]; other site
403833003384	putative catalytic residue [active]
403833003385	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
403833003386	EDD domain protein, DegV family; Region: DegV; TIGR00762
403833003387	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
403833003388	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
403833003389	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
403833003390	dimer interface [polypeptide binding]; other site
403833003391	active site
403833003392	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
403833003393	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
403833003394	WHG domain; Region: WHG; pfam13305
403833003395	Transposase; Region: DEDD_Tnp_IS110; pfam01548
403833003396	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
403833003397	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
403833003398	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
403833003399	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
403833003400	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
403833003401	Walker A/P-loop; other site
403833003402	ATP binding site [chemical binding]; other site
403833003403	Q-loop/lid; other site
403833003404	ABC transporter signature motif; other site
403833003405	Walker B; other site
403833003406	D-loop; other site
403833003407	H-loop/switch region; other site
403833003408	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
403833003409	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
403833003410	FeS/SAM binding site; other site
403833003411	Domain of unknown function (DUF4008); Region: DUF4008; cl14869
403833003412	Transposase; Region: DEDD_Tnp_IS110; pfam01548
403833003413	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
403833003414	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
403833003415	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
403833003416	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
403833003417	Walker A/P-loop; other site
403833003418	ATP binding site [chemical binding]; other site
403833003419	Q-loop/lid; other site
403833003420	ABC transporter signature motif; other site
403833003421	Walker B; other site
403833003422	D-loop; other site
403833003423	H-loop/switch region; other site
403833003424	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
403833003425	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
403833003426	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
403833003427	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
403833003428	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
403833003429	Walker A/P-loop; other site
403833003430	ATP binding site [chemical binding]; other site
403833003431	Q-loop/lid; other site
403833003432	ABC transporter signature motif; other site
403833003433	Walker B; other site
403833003434	D-loop; other site
403833003435	H-loop/switch region; other site
403833003436	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
403833003437	Transposase; Region: DEDD_Tnp_IS110; pfam01548
403833003438	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
403833003439	radical SAM/SPASM domain Clo7bot peptide maturase; Region: rSAM_Clo7bot; TIGR04334
403833003440	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
403833003441	FeS/SAM binding site; other site
403833003442	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
403833003443	RRXRR protein; Region: RRXRR; pfam14239
403833003444	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
403833003445	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
403833003446	active site
403833003447	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
403833003448	homodimer interface [polypeptide binding]; other site
403833003449	active site
403833003450	putative chemical substrate binding site [chemical binding]; other site
403833003451	metal binding site [ion binding]; metal-binding site
403833003452	GTP-binding protein YchF; Reviewed; Region: PRK09601
403833003453	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
403833003454	G1 box; other site
403833003455	GTP/Mg2+ binding site [chemical binding]; other site
403833003456	Switch I region; other site
403833003457	G3 box; other site
403833003458	Switch II region; other site
403833003459	G4 box; other site
403833003460	G5 box; other site
403833003461	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
403833003462	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
403833003463	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
403833003464	NAD binding site [chemical binding]; other site
403833003465	homodimer interface [polypeptide binding]; other site
403833003466	active site
403833003467	substrate binding site [chemical binding]; other site
403833003468	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
403833003469	active site
403833003470	glucose-6-phosphate isomerase; Provisional; Region: PRK00973
403833003471	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
403833003472	active site
403833003473	dimer interface [polypeptide binding]; other site
403833003474	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
403833003475	dimer interface [polypeptide binding]; other site
403833003476	active site
403833003477	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
403833003478	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
403833003479	CoA-binding site [chemical binding]; other site
403833003480	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
403833003481	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
403833003482	Protein of unknown function DUF45; Region: DUF45; pfam01863
403833003483	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
403833003484	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
403833003485	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
403833003486	ATP binding site [chemical binding]; other site
403833003487	putative Mg++ binding site [ion binding]; other site
403833003488	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
403833003489	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
403833003490	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
403833003491	HsdM N-terminal domain; Region: HsdM_N; pfam12161
403833003492	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
403833003493	Methyltransferase domain; Region: Methyltransf_26; pfam13659
403833003494	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
403833003495	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
403833003496	Walker A/P-loop; other site
403833003497	ATP binding site [chemical binding]; other site
403833003498	Q-loop/lid; other site
403833003499	ABC transporter signature motif; other site
403833003500	Walker B; other site
403833003501	D-loop; other site
403833003502	H-loop/switch region; other site
403833003503	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
403833003504	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
403833003505	FtsX-like permease family; Region: FtsX; pfam02687
403833003506	FtsX-like permease family; Region: FtsX; pfam02687
403833003507	Coenzyme A transferase; Region: CoA_trans; cl17247
403833003508	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
403833003509	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cd03440
403833003510	active site 2 [active]
403833003511	active site 1 [active]
403833003512	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
403833003513	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
403833003514	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
403833003515	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
403833003516	NAD(P) binding site [chemical binding]; other site
403833003517	lysine-2,3-aminomutase; Region: lys_2_3_AblA; TIGR03820
403833003518	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
403833003519	FeS/SAM binding site; other site
403833003520	Lysine-2,3-aminomutase; Region: LAM_C; pfam12544
403833003521	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
403833003522	dimer interaction site [polypeptide binding]; other site
403833003523	substrate-binding tunnel; other site
403833003524	active site
403833003525	catalytic site [active]
403833003526	substrate binding site [chemical binding]; other site
403833003527	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
403833003528	Walker A/P-loop; other site
403833003529	ATP binding site [chemical binding]; other site
403833003530	Q-loop/lid; other site
403833003531	ABC transporter signature motif; other site
403833003532	Walker B; other site
403833003533	D-loop; other site
403833003534	H-loop/switch region; other site
403833003535	D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043
403833003536	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
403833003537	B12 binding domain (B12-BD). This domain binds different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide, it is found in several enzymes, such as glutamate mutase, methionine synthase...; Region: B12-binding; cd02067
403833003538	B12 binding site [chemical binding]; other site
403833003539	cobalt ligand [ion binding]; other site
403833003540	heat shock protein 90; Provisional; Region: PRK05218
403833003541	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
403833003542	ATP binding site [chemical binding]; other site
403833003543	Mg2+ binding site [ion binding]; other site
403833003544	G-X-G motif; other site
403833003545	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
403833003546	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
403833003547	putative ligand binding pocket/active site [active]
403833003548	putative metal binding site [ion binding]; other site
403833003549	Asp23 family; Region: Asp23; pfam03780
403833003550	DAK2 domain fusion protein YloV; Region: YloV; TIGR03599
403833003551	DAK2 domain; Region: Dak2; pfam02734
403833003552	glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348
403833003553	motif 1; other site
403833003554	dimer interface [polypeptide binding]; other site
403833003555	active site
403833003556	motif 2; other site
403833003557	motif 3; other site
403833003558	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
403833003559	HD domain; Region: HD; pfam01966
403833003560	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
403833003561	RNase_H superfamily; Region: RNase_H_2; pfam13482
403833003562	Chromate transporter; Region: Chromate_transp; pfam02417
403833003563	Chromate transporter; Region: Chromate_transp; pfam02417
403833003564	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
403833003565	Thymidylate kinase; Region: Thymidylate_kin; pfam02223
403833003566	TMP-binding site; other site
403833003567	ATP-binding site [chemical binding]; other site
403833003568	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
403833003569	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
403833003570	Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110
403833003571	putative active site [active]
403833003572	catalytic site [active]
403833003573	catalytic domain repeat 2 of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_2; cd09112
403833003574	putative active site [active]
403833003575	catalytic site [active]
403833003576	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
403833003577	zinc binding site [ion binding]; other site
403833003578	putative ligand binding site [chemical binding]; other site
403833003579	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
403833003580	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
403833003581	TM-ABC transporter signature motif; other site
403833003582	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
403833003583	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
403833003584	Walker A/P-loop; other site
403833003585	ATP binding site [chemical binding]; other site
403833003586	Q-loop/lid; other site
403833003587	ABC transporter signature motif; other site
403833003588	Walker B; other site
403833003589	D-loop; other site
403833003590	H-loop/switch region; other site
403833003591	ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074
403833003592	Family description; Region: UvrD_C_2; pfam13538
403833003593	CorA-like Mg2+ transporter protein; Region: CorA; pfam01544
403833003594	Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828
403833003595	oligomer interface [polypeptide binding]; other site
403833003596	metal binding site [ion binding]; metal-binding site
403833003597	metal binding site [ion binding]; metal-binding site
403833003598	Cl binding site [ion binding]; other site
403833003599	aspartate ring; other site
403833003600	putative hydrophobic gate; other site
403833003601	periplasmic entrance; other site
403833003602	diaminopimelate aminotransferase; Provisional; Region: PRK13983
403833003603	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like1; cd05650
403833003604	metal binding site [ion binding]; metal-binding site
403833003605	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205
403833003606	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
403833003607	glycogen synthase; Provisional; Region: glgA; PRK00654
403833003608	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
403833003609	ADP-binding pocket [chemical binding]; other site
403833003610	homodimer interface [polypeptide binding]; other site
403833003611	ADP-glucose phosphorylase; Region: PLN02643
403833003612	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
403833003613	dimer interface [polypeptide binding]; other site
403833003614	active site
403833003615	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
403833003616	M28 Zn-Peptidases; Region: M28_like_7; cd05643
403833003617	Peptidase family M28; Region: Peptidase_M28; pfam04389
403833003618	putative metal binding site [ion binding]; other site
403833003619	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
403833003620	Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802
403833003621	Alpha-glucosidase II (alpha-D-glucoside glucohydrolase) is a glycosyl hydrolase family 31 (GH31) enzyme, found in bacteria and plants, which has exo-alpha-1,4-glucosidase and oligo-1,6-glucosidase activities. Alpha-glucosidase II has been characterized...; Region: GH31_glucosidase_II_MalA; cd06604
403833003622	trimer interface [polypeptide binding]; other site
403833003623	active site
403833003624	homohexamer (dimer of homotrimer) interface [polypeptide binding]; other site
403833003625	catalytic site [active]
403833003626	Predicted membrane protein [Function unknown]; Region: COG3462
403833003627	Short C-terminal domain; Region: SHOCT; pfam09851
403833003628	Short C-terminal domain; Region: SHOCT; pfam09851
403833003629	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
403833003630	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
403833003631	Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098
403833003632	alanine-tRNA ligase; Region: PLN02961
403833003633	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
403833003634	FOG: WD40 repeat [General function prediction only]; Region: COG2319
403833003635	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
403833003636	structural tetrad; other site
403833003637	FOG: WD40 repeat [General function prediction only]; Region: COG2319
403833003638	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
403833003639	structural tetrad; other site
403833003640	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
403833003641	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
403833003642	Protein export membrane protein; Region: SecD_SecF; pfam02355
403833003643	protein-export membrane protein SecD; Region: secD; TIGR01129
403833003644	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
403833003645	Preprotein translocase subunit; Region: YajC; pfam02699
403833003646	septum formation inhibitor; Provisional; Region: minC; PRK13992
403833003647	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
403833003648	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
403833003649	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
403833003650	oligomer interface [polypeptide binding]; other site
403833003651	active site
403833003652	metal binding site [ion binding]; metal-binding site
403833003653	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
403833003654	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
403833003655	oligomer interface [polypeptide binding]; other site
403833003656	active site
403833003657	metal binding site [ion binding]; metal-binding site
403833003658	Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363
403833003659	M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656
403833003660	oligomer interface [polypeptide binding]; other site
403833003661	active site
403833003662	metal binding site [ion binding]; metal-binding site
403833003663	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
403833003664	active site
403833003665	dimer interfaces [polypeptide binding]; other site
403833003666	catalytic residues [active]
403833003667	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
403833003668	non-specific DNA binding site [nucleotide binding]; other site
403833003669	salt bridge; other site
403833003670	sequence-specific DNA binding site [nucleotide binding]; other site
403833003671	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833003672	dimer interface [polypeptide binding]; other site
403833003673	conserved gate region; other site
403833003674	putative PBP binding loops; other site
403833003675	ABC-ATPase subunit interface; other site
403833003676	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
403833003677	glycine betaine/L-proline transport ATP binding subunit; Region: proV; TIGR01186
403833003678	Walker A/P-loop; other site
403833003679	ATP binding site [chemical binding]; other site
403833003680	Q-loop/lid; other site
403833003681	ABC transporter signature motif; other site
403833003682	Walker B; other site
403833003683	D-loop; other site
403833003684	H-loop/switch region; other site
403833003685	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
403833003686	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833003687	dimer interface [polypeptide binding]; other site
403833003688	conserved gate region; other site
403833003689	ABC-ATPase subunit interface; other site
403833003690	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
403833003691	Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732
403833003692	ABC-type metal ion transport system, permease component [Inorganic ion transport and metabolism]; Region: AbcD; COG2011
403833003693	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
403833003694	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
403833003695	Walker A/P-loop; other site
403833003696	ATP binding site [chemical binding]; other site
403833003697	Q-loop/lid; other site
403833003698	ABC transporter signature motif; other site
403833003699	Walker B; other site
403833003700	D-loop; other site
403833003701	H-loop/switch region; other site
403833003702	NIL domain; Region: NIL; pfam09383
403833003703	ABC-type metal ion transport system, periplasmic component/surface antigen [Inorganic ion transport and metabolism]; Region: NlpA; COG1464
403833003704	NLPA lipoprotein; Region: Lipoprotein_9; pfam03180
403833003705	Uncharacterized flavoproteins [Energy production and conversion]; Region: FpaA; COG0426
403833003706	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
403833003707	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
403833003708	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
403833003709	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
403833003710	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
403833003711	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
403833003712	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
403833003713	putative active site [active]
403833003714	N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859
403833003715	glycogen binding site [chemical binding]; other site
403833003716	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
403833003717	Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318
403833003718	active site
403833003719	Na/Ca binding site [ion binding]; other site
403833003720	catalytic site [active]
403833003721	Domain of unknown function (DUF1939); Region: DUF1939; pfam09154
403833003722	Protein of unknown function (DUF554); Region: DUF554; pfam04474
403833003723	Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876
403833003724	metal binding site [ion binding]; metal-binding site
403833003725	putative glucosyl-3-phosphoglycerate synthase; Provisional; Region: PRK13915
403833003726	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
403833003727	Domain of unknown function (DUF3783); Region: DUF3783; pfam12646
403833003728	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
403833003729	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
403833003730	Walker A/P-loop; other site
403833003731	ATP binding site [chemical binding]; other site
403833003732	Q-loop/lid; other site
403833003733	ABC transporter signature motif; other site
403833003734	Walker B; other site
403833003735	D-loop; other site
403833003736	H-loop/switch region; other site
403833003737	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
403833003738	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833003739	dimer interface [polypeptide binding]; other site
403833003740	conserved gate region; other site
403833003741	putative PBP binding loops; other site
403833003742	ABC-ATPase subunit interface; other site
403833003743	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
403833003744	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
403833003745	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
403833003746	catalytic loop [active]
403833003747	iron binding site [ion binding]; other site
403833003748	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
403833003749	[FeFe] hydrogenase, group A; Region: FeFe_hydrog_A; TIGR02512
403833003750	Iron only hydrogenase large subunit, C-terminal domain; Region: Fe_hyd_lg_C; pfam02906
403833003751	Iron hydrogenase small subunit; Region: Fe_hyd_SSU; pfam02256
403833003752	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
403833003753	SLBB domain; Region: SLBB; pfam10531
403833003754	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589
403833003755	Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257
403833003756	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
403833003757	putative dimer interface [polypeptide binding]; other site
403833003758	[2Fe-2S] cluster binding site [ion binding]; other site
403833003759	threonine synthase; Reviewed; Region: PRK06721
403833003760	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
403833003761	homodimer interface [polypeptide binding]; other site
403833003762	pyridoxal 5'-phosphate binding site [chemical binding]; other site
403833003763	catalytic residue [active]
403833003764	homoserine dehydrogenase; Provisional; Region: PRK06349
403833003765	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
403833003766	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
403833003767	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
403833003768	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
403833003769	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
403833003770	putative substrate binding site [chemical binding]; other site
403833003771	putative ATP binding site [chemical binding]; other site
403833003772	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
403833003773	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
403833003774	active site
403833003775	catalytic tetrad [active]
403833003776	RRXRR protein; Region: RRXRR; pfam14239
403833003777	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
403833003778	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
403833003779	active site
403833003780	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
403833003781	oligomerisation interface [polypeptide binding]; other site
403833003782	mobile loop; other site
403833003783	roof hairpin; other site
403833003784	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
403833003785	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
403833003786	ring oligomerisation interface [polypeptide binding]; other site
403833003787	ATP/Mg binding site [chemical binding]; other site
403833003788	stacking interactions; other site
403833003789	hinge regions; other site
403833003790	Protein of unknown function (DUF401); Region: DUF401; cl00830
403833003791	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
403833003792	active site
403833003793	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
403833003794	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
403833003795	active site
403833003796	intersubunit interactions; other site
403833003797	catalytic residue [active]
403833003798	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
403833003799	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
403833003800	ligand binding site [chemical binding]; other site
403833003801	flexible hinge region; other site
403833003802	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
403833003803	putative switch regulator; other site
403833003804	non-specific DNA interactions [nucleotide binding]; other site
403833003805	DNA binding site [nucleotide binding]
403833003806	sequence specific DNA binding site [nucleotide binding]; other site
403833003807	putative cAMP binding site [chemical binding]; other site
403833003808	hybrid cluster protein; Provisional; Region: PRK05290
403833003809	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
403833003810	ACS interaction site; other site
403833003811	CODH interaction site; other site
403833003812	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
403833003813	ACS interaction site; other site
403833003814	CODH interaction site; other site
403833003815	metal cluster binding site [ion binding]; other site
403833003816	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
403833003817	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
403833003818	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
403833003819	Uncharacterized conserved protein related to dihydrodipicolinate reductase [Function unknown]; Region: COG3804
403833003820	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
403833003821	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640
403833003822	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
403833003823	catalytic residue [active]
403833003824	D-Lysine 5,6-aminomutase alpha subunit; Region: Lys-AminoMut_A; pfam09043
403833003825	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
403833003826	B12 binding site [chemical binding]; other site
403833003827	DNA polymerase III subunit beta; Validated; Region: PRK05643
403833003828	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
403833003829	putative DNA binding surface [nucleotide binding]; other site
403833003830	dimer interface [polypeptide binding]; other site
403833003831	beta-clamp/clamp loader binding surface; other site
403833003832	beta-clamp/translesion DNA polymerase binding surface; other site
403833003833	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
403833003834	homotrimer interaction site [polypeptide binding]; other site
403833003835	zinc binding site [ion binding]; other site
403833003836	CDP-binding sites; other site
403833003837	Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559
403833003838	Active_site [active]
403833003839	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
403833003840	Major Facilitator Superfamily; Region: MFS_1; pfam07690
403833003841	putative substrate translocation pore; other site
403833003842	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
403833003843	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
403833003844	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078
403833003845	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
403833003846	Staphylococcal nuclease homologues; Region: SNc; smart00318
403833003847	Catalytic site; other site
403833003848	Staphylococcal nuclease homologue; Region: SNase; pfam00565
403833003849	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
403833003850	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
403833003851	Predicted membrane protein, hemolysin III homolog [General function prediction only]; Region: COG1272
403833003852	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
403833003853	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_12; cd13142
403833003854	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
403833003855	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
403833003856	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
403833003857	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
403833003858	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
403833003859	RNA binding site [nucleotide binding]; other site
403833003860	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
403833003861	active site
403833003862	catalytic residues [active]
403833003863	Transposase; Region: HTH_Tnp_1; pfam01527
403833003864	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
403833003865	HTH-like domain; Region: HTH_21; pfam13276
403833003866	ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866
403833003867	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
403833003868	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
403833003869	Walker A/P-loop; other site
403833003870	ATP binding site [chemical binding]; other site
403833003871	Q-loop/lid; other site
403833003872	ABC transporter signature motif; other site
403833003873	Walker B; other site
403833003874	D-loop; other site
403833003875	H-loop/switch region; other site
403833003876	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
403833003877	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
403833003878	MarR family; Region: MarR; pfam01047
403833003879	MarR family; Region: MarR_2; cl17246
403833003880	Iron-containing alcohol dehydrogenase; Region: Fe-ADH8; cd08186
403833003881	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
403833003882	putative active site [active]
403833003883	metal binding site [ion binding]; metal-binding site
403833003884	Transposase; Region: DEDD_Tnp_IS110; pfam01548
403833003885	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
403833003886	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
403833003887	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
403833003888	Bacitracin resistance protein BacA; Region: BacA; pfam02673
403833003889	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
403833003890	Dehydroquinase class II; Region: DHquinase_II; pfam01220
403833003891	trimer interface [polypeptide binding]; other site
403833003892	active site
403833003893	dimer interface [polypeptide binding]; other site
403833003894	bifunctional shikimate kinase/3-dehydroquinate synthase; Provisional; Region: PRK13951
403833003895	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
403833003896	ADP binding site [chemical binding]; other site
403833003897	magnesium binding site [ion binding]; other site
403833003898	putative shikimate binding site; other site
403833003899	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
403833003900	active site
403833003901	NAD binding site [chemical binding]; other site
403833003902	metal binding site [ion binding]; metal-binding site
403833003903	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
403833003904	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
403833003905	Tetramer interface [polypeptide binding]; other site
403833003906	active site
403833003907	FMN-binding site [chemical binding]; other site
403833003908	Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169
403833003909	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
403833003910	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
403833003911	shikimate binding site; other site
403833003912	NAD(P) binding site [chemical binding]; other site
403833003913	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
403833003914	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
403833003915	hinge; other site
403833003916	active site
403833003917	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
403833003918	prephenate dehydrogenase; Validated; Region: PRK08507
403833003919	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
403833003920	phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361
403833003921	Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298
403833003922	Acylphosphatases [Energy production and conversion]; Region: AcyP; COG1254
403833003923	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
403833003924	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
403833003925	substrate binding site [chemical binding]; other site
403833003926	active site
403833003927	catalytic residues [active]
403833003928	heterodimer interface [polypeptide binding]; other site
403833003929	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
403833003930	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
403833003931	pyridoxal 5'-phosphate binding site [chemical binding]; other site
403833003932	catalytic residue [active]
403833003933	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
403833003934	active site
403833003935	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
403833003936	active site
403833003937	ribulose/triose binding site [chemical binding]; other site
403833003938	phosphate binding site [ion binding]; other site
403833003939	substrate (anthranilate) binding pocket [chemical binding]; other site
403833003940	product (indole) binding pocket [chemical binding]; other site
403833003941	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
403833003942	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
403833003943	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
403833003944	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
403833003945	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
403833003946	glutamine binding [chemical binding]; other site
403833003947	catalytic triad [active]
403833003948	Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147
403833003949	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
403833003950	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
403833003951	putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830
403833003952	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
403833003953	EDD domain protein, DegV family; Region: DegV; TIGR00762
403833003954	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
403833003955	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
403833003956	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
403833003957	nucleotide binding site [chemical binding]; other site
403833003958	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
403833003959	substrate binding site; other site
403833003960	dimer interface; other site
403833003961	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
403833003962	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
403833003963	metal binding site [ion binding]; metal-binding site
403833003964	dimer interface [polypeptide binding]; other site
403833003965	Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992
403833003966	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
403833003967	inhibitor-cofactor binding pocket; inhibition site
403833003968	pyridoxal 5'-phosphate binding site [chemical binding]; other site
403833003969	catalytic residue [active]
403833003970	aspartate kinase; Reviewed; Region: PRK06635
403833003971	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
403833003972	putative nucleotide binding site [chemical binding]; other site
403833003973	putative catalytic residues [active]
403833003974	putative Mg ion binding site [ion binding]; other site
403833003975	putative aspartate binding site [chemical binding]; other site
403833003976	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII and related proteins; Region: ACT_AK-LysC-DapG-like_1; cd04891
403833003977	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
403833003978	Tetrahydrodipicolinate succinyltransferase N-terminal; Region: DapH_N; pfam08503
403833003979	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-acetyltransferase; Region: DapD_Ac; TIGR03532
403833003980	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
403833003981	trimer interface [polypeptide binding]; other site
403833003982	active site
403833003983	substrate binding site [chemical binding]; other site
403833003984	CoA binding site [chemical binding]; other site
403833003985	dihydrodipicolinate reductase; Provisional; Region: PRK00048
403833003986	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
403833003987	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
403833003988	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
403833003989	dihydrodipicolinate synthase; Region: dapA; TIGR00674
403833003990	dimer interface [polypeptide binding]; other site
403833003991	active site
403833003992	catalytic residue [active]
403833003993	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
403833003994	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
403833003995	active site
403833003996	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
403833003997	substrate binding site [chemical binding]; other site
403833003998	catalytic residues [active]
403833003999	dimer interface [polypeptide binding]; other site
403833004000	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
403833004001	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
403833004002	HPP family; Region: HPP; pfam04982
403833004003	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
403833004004	POTRA domain, ShlB-type; Region: POTRA_2; pfam08479
403833004005	Surface antigen; Region: Bac_surface_Ag; pfam01103
403833004006	FAD-dependent thymidylate synthase; Reviewed; Region: thyX; PRK00847
403833004007	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
403833004008	TPR motif; other site
403833004009	TPR repeat; Region: TPR_11; pfam13414
403833004010	Protein of unknown function (DUF342); Region: DUF342; pfam03961
403833004011	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
403833004012	Uncharacterized BCR, COG1636; Region: DUF208; pfam02677
403833004013	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
403833004014	Helix-hairpin-helix motif; Region: HHH; pfam00633
403833004015	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
403833004016	Helix-hairpin-helix motif; Region: HHH; pfam00633
403833004017	Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872
403833004018	active site
403833004019	NAD binding site [chemical binding]; other site
403833004020	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
403833004021	LexA repressor; Validated; Region: PRK00215
403833004022	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
403833004023	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
403833004024	Catalytic site [active]
403833004025	DNA gyrase subunit A; Validated; Region: PRK05560
403833004026	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
403833004027	CAP-like domain; other site
403833004028	active site
403833004029	primary dimer interface [polypeptide binding]; other site
403833004030	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
403833004031	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
403833004032	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
403833004033	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
403833004034	methionyl-tRNA synthetase; Reviewed; Region: PRK12267
403833004035	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
403833004036	active site
403833004037	HIGH motif; other site
403833004038	KMSKS motif; other site
403833004039	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
403833004040	tRNA binding surface [nucleotide binding]; other site
403833004041	anticodon binding site; other site
403833004042	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
403833004043	putative tRNA-binding site [nucleotide binding]; other site
403833004044	dimer interface [polypeptide binding]; other site
403833004045	YcfA-like protein; Region: YcfA; pfam07927
403833004046	Uncharacterized protein family (UPF0150); Region: UPF0150; pfam03681
403833004047	prolyl-tRNA synthetase; Provisional; Region: PRK09194
403833004048	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
403833004049	dimer interface [polypeptide binding]; other site
403833004050	motif 1; other site
403833004051	active site
403833004052	motif 2; other site
403833004053	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
403833004054	putative deacylase active site [active]
403833004055	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
403833004056	active site
403833004057	motif 3; other site
403833004058	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
403833004059	anticodon binding site; other site
403833004060	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
403833004061	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
403833004062	Divergent AAA domain; Region: AAA_4; pfam04326
403833004063	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
403833004064	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
403833004065	Uncharacterized protein family (UPF0175); Region: UPF0175; pfam03683
403833004066	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
403833004067	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
403833004068	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531
403833004069	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
403833004070	Alkaline phosphatase [Inorganic ion transport and metabolism]; Region: PhoA; COG1785
403833004071	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
403833004072	dimer interface [polypeptide binding]; other site
403833004073	active site
403833004074	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
403833004075	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
403833004076	Probable transposase; Region: OrfB_IS605; pfam01385
403833004077	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
403833004078	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
403833004079	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
403833004080	putative active site [active]
403833004081	putative NTP binding site [chemical binding]; other site
403833004082	putative nucleic acid binding site [nucleotide binding]; other site
403833004083	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
403833004084	NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767
403833004085	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
403833004086	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584
403833004087	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
403833004088	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
403833004089	Walker A motif; other site
403833004090	ATP binding site [chemical binding]; other site
403833004091	Walker B motif; other site
403833004092	arginine finger; other site
403833004093	Transposase; Region: DEDD_Tnp_IS110; pfam01548
403833004094	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
403833004095	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
403833004096	Transcriptional regulators [Transcription]; Region: PurR; COG1609
403833004097	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
403833004098	DNA binding site [nucleotide binding]
403833004099	domain linker motif; other site
403833004100	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
403833004101	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
403833004102	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
403833004103	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833004104	dimer interface [polypeptide binding]; other site
403833004105	conserved gate region; other site
403833004106	putative PBP binding loops; other site
403833004107	ABC-ATPase subunit interface; other site
403833004108	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
403833004109	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833004110	dimer interface [polypeptide binding]; other site
403833004111	conserved gate region; other site
403833004112	putative PBP binding loops; other site
403833004113	ABC-ATPase subunit interface; other site
403833004114	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
403833004115	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
403833004116	active site
403833004117	homodimer interface [polypeptide binding]; other site
403833004118	catalytic site [active]
403833004119	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
403833004120	catalytic residues [active]
403833004121	Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344
403833004122	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
403833004123	putative active site [active]
403833004124	putative NTP binding site [chemical binding]; other site
403833004125	putative nucleic acid binding site [nucleotide binding]; other site
403833004126	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
403833004127	Methyltransferase domain; Region: Methyltransf_26; pfam13659
403833004128	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
403833004129	hypothetical protein; Validated; Region: PRK08116
403833004130	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
403833004131	DNA-binding site [nucleotide binding]; DNA binding site
403833004132	Protein of unknown function (DUF2922); Region: DUF2922; pfam11148
403833004133	Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464
403833004134	exopolysaccharide biosynthesis polyprenyl glycosylphosphotransferase; Region: EPS_sugtrans; TIGR03025
403833004135	Bacterial sugar transferase; Region: Bac_transf; pfam02397
403833004136	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
403833004137	This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen.  It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794
403833004138	UDP-N-acetylglucosamine 4,6-dehydratase/5-epimerase; Region: FnlA; TIGR04130
403833004139	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
403833004140	NAD(P) binding site [chemical binding]; other site
403833004141	homodimer interface [polypeptide binding]; other site
403833004142	substrate binding site [chemical binding]; other site
403833004143	active site
403833004144	Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485
403833004145	UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381
403833004146	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
403833004147	active site
403833004148	homodimer interface [polypeptide binding]; other site
403833004149	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
403833004150	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
403833004151	NAD(P) binding site [chemical binding]; other site
403833004152	active site
403833004153	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
403833004154	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
403833004155	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
403833004156	active site
403833004157	UDP-N-acetylglucosamine 2-epimerase; Region: Epimerase_2; pfam02350
403833004158	homodimer interface [polypeptide binding]; other site
403833004159	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
403833004160	Transposase; Region: DDE_Tnp_ISL3; pfam01610
403833004161	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
403833004162	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
403833004163	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
403833004164	UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236
403833004165	Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase  family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786
403833004166	active site
403833004167	homodimer interface [polypeptide binding]; other site
403833004168	Methyltransferase domain; Region: Methyltransf_12; pfam08242
403833004169	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
403833004170	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
403833004171	This family is most closely related to the GT1 family of glycosyltransferases. wlbH in Bordetella parapertussis has been shown to be required for the biosynthesis of a trisaccharide that, when attached to the B. pertussis lipopolysaccharide (LPS) core; Region: GT1_wlbH_like; cd03798
403833004172	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
403833004173	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
403833004174	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
403833004175	Predicted nuclease of the RNAse H fold, HicB family [General    function prediction only]; Region: COG1598
403833004176	conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784
403833004177	Putative transposase, YhgA-like; Region: Transposase_31; pfam04754
403833004178	EDD domain protein, DegV family; Region: DegV; TIGR00762
403833004179	Uncharacterized protein, DegV family COG1307; Region: DegV; pfam02645
403833004180	Uncharacterized conserved protein [Function unknown]; Region: COG2445
403833004181	Membrane protein of unknown function (DUF340); Region: DUF340; pfam03956
403833004182	Membrane protein of unknown function (DUF340); Region: DUF340; cl01028
403833004183	Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836
403833004184	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
403833004185	Substrate binding site; other site
403833004186	Cupin domain; Region: Cupin_2; cl17218
403833004187	glycogen branching enzyme; Provisional; Region: PRK05402
403833004188	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
403833004189	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
403833004190	active site
403833004191	catalytic site [active]
403833004192	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
403833004193	DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481
403833004194	DNA protecting protein DprA; Region: dprA; TIGR00732
403833004195	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
403833004196	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
403833004197	S-adenosylmethionine binding site [chemical binding]; other site
403833004198	HflC protein; Region: hflC; TIGR01932
403833004199	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
403833004200	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
403833004201	HflK protein; Region: hflK; TIGR01933
403833004202	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
403833004203	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
403833004204	NAD(P) binding site [chemical binding]; other site
403833004205	active site
403833004206	recombination factor protein RarA; Reviewed; Region: PRK13342
403833004207	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
403833004208	Walker A motif; other site
403833004209	ATP binding site [chemical binding]; other site
403833004210	Walker B motif; other site
403833004211	arginine finger; other site
403833004212	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
403833004213	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
403833004214	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
403833004215	Walker A/P-loop; other site
403833004216	ATP binding site [chemical binding]; other site
403833004217	Q-loop/lid; other site
403833004218	ABC transporter signature motif; other site
403833004219	Walker B; other site
403833004220	D-loop; other site
403833004221	H-loop/switch region; other site
403833004222	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
403833004223	ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnK; COG4107
403833004224	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
403833004225	Walker A/P-loop; other site
403833004226	ATP binding site [chemical binding]; other site
403833004227	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
403833004228	Q-loop/lid; other site
403833004229	ABC transporter signature motif; other site
403833004230	Walker B; other site
403833004231	D-loop; other site
403833004232	H-loop/switch region; other site
403833004233	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
403833004234	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
403833004235	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
403833004236	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
403833004237	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833004238	dimer interface [polypeptide binding]; other site
403833004239	conserved gate region; other site
403833004240	putative PBP binding loops; other site
403833004241	ABC-ATPase subunit interface; other site
403833004242	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
403833004243	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
403833004244	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833004245	dimer interface [polypeptide binding]; other site
403833004246	conserved gate region; other site
403833004247	putative PBP binding loops; other site
403833004248	ABC-ATPase subunit interface; other site
403833004249	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
403833004250	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833004251	dimer interface [polypeptide binding]; other site
403833004252	conserved gate region; other site
403833004253	ABC-ATPase subunit interface; other site
403833004254	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
403833004255	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833004256	dimer interface [polypeptide binding]; other site
403833004257	conserved gate region; other site
403833004258	putative PBP binding loops; other site
403833004259	ABC-ATPase subunit interface; other site
403833004260	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
403833004261	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
403833004262	Walker A/P-loop; other site
403833004263	ATP binding site [chemical binding]; other site
403833004264	Q-loop/lid; other site
403833004265	ABC transporter signature motif; other site
403833004266	Walker B; other site
403833004267	D-loop; other site
403833004268	H-loop/switch region; other site
403833004269	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
403833004270	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
403833004271	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
403833004272	Walker A/P-loop; other site
403833004273	ATP binding site [chemical binding]; other site
403833004274	Q-loop/lid; other site
403833004275	ABC transporter signature motif; other site
403833004276	Walker B; other site
403833004277	D-loop; other site
403833004278	H-loop/switch region; other site
403833004279	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
403833004280	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
403833004281	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833004282	dimer interface [polypeptide binding]; other site
403833004283	conserved gate region; other site
403833004284	putative PBP binding loops; other site
403833004285	ABC-ATPase subunit interface; other site
403833004286	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
403833004287	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
403833004288	Walker A/P-loop; other site
403833004289	ATP binding site [chemical binding]; other site
403833004290	Q-loop/lid; other site
403833004291	ABC transporter signature motif; other site
403833004292	Walker B; other site
403833004293	D-loop; other site
403833004294	H-loop/switch region; other site
403833004295	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
403833004296	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
403833004297	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
403833004298	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
403833004299	Walker A/P-loop; other site
403833004300	ATP binding site [chemical binding]; other site
403833004301	Q-loop/lid; other site
403833004302	ABC transporter signature motif; other site
403833004303	Walker B; other site
403833004304	D-loop; other site
403833004305	H-loop/switch region; other site
403833004306	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
403833004307	Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641
403833004308	FeS/SAM binding site; other site
403833004309	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
403833004310	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
403833004311	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
403833004312	ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254
403833004313	Walker A/P-loop; other site
403833004314	ATP binding site [chemical binding]; other site
403833004315	Q-loop/lid; other site
403833004316	ABC transporter signature motif; other site
403833004317	Walker B; other site
403833004318	D-loop; other site
403833004319	H-loop/switch region; other site
403833004320	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
403833004321	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
403833004322	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
403833004323	Walker A/P-loop; other site
403833004324	ATP binding site [chemical binding]; other site
403833004325	Q-loop/lid; other site
403833004326	ABC transporter signature motif; other site
403833004327	Walker B; other site
403833004328	D-loop; other site
403833004329	H-loop/switch region; other site
403833004330	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
403833004331	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
403833004332	dimerization interface [polypeptide binding]; other site
403833004333	putative Zn2+ binding site [ion binding]; other site
403833004334	putative DNA binding site [nucleotide binding]; other site
403833004335	AAA ATPase domain; Region: AAA_16; pfam13191
403833004336	Archaeal ATPase; Region: Arch_ATPase; pfam01637
403833004337	Archaea bacterial proteins of unknown function; Region: DUF234; pfam03008
403833004338	Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188
403833004339	metal binding site [ion binding]; metal-binding site
403833004340	substrate binding pocket [chemical binding]; other site
403833004341	nicotinate phosphoribosyltransferase; Provisional; Region: PRK07188
403833004342	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275
403833004343	Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275
403833004344	active site
403833004345	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
403833004346	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
403833004347	DNA binding site [nucleotide binding]
403833004348	active site
403833004349	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
403833004350	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
403833004351	Walker A/P-loop; other site
403833004352	ATP binding site [chemical binding]; other site
403833004353	Q-loop/lid; other site
403833004354	SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968
403833004355	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
403833004356	Q-loop/lid; other site
403833004357	ABC transporter signature motif; other site
403833004358	Walker B; other site
403833004359	D-loop; other site
403833004360	H-loop/switch region; other site
403833004361	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
403833004362	Fe-S cluster binding site [ion binding]; other site
403833004363	active site
403833004364	Predicted permeases [General function prediction only]; Region: COG0795
403833004365	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
403833004366	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
403833004367	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
403833004368	PhoU domain; Region: PhoU; pfam01895
403833004369	NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061
403833004370	ATP-NAD kinase; Region: NAD_kinase; pfam01513
403833004371	YGGT family; Region: YGGT; pfam02325
403833004372	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
403833004373	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
403833004374	catalytic residue [active]
403833004375	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
403833004376	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
403833004377	Walker A motif; other site
403833004378	ATP binding site [chemical binding]; other site
403833004379	Walker B motif; other site
403833004380	arginine finger; other site
403833004381	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
403833004382	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
403833004383	AsnRS_cyto_like_N: N-terminal, anticodon recognition domain of the type found in human and Saccharomyces cerevisiae cytoplasmic asparaginyl-tRNA synthetase (AsnRS), in Brugia malayai AsnRs and, in various putative bacterial AsnRSs.  This domain is a...; Region: AsnRS_cyto_like_N; cd04323
403833004384	putative dimer interface [polypeptide binding]; other site
403833004385	putative anticodon binding site; other site
403833004386	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
403833004387	homodimer interface [polypeptide binding]; other site
403833004388	motif 1; other site
403833004389	motif 2; other site
403833004390	active site
403833004391	motif 3; other site
403833004392	NAD-dependent deacetylase; Provisional; Region: PRK14138
403833004393	SIR2 family of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2-fam; cd01407
403833004394	NAD+ binding site [chemical binding]; other site
403833004395	substrate binding site [chemical binding]; other site
403833004396	Zn binding site [ion binding]; other site
403833004397	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_HprK; cl00270
403833004398	active site
403833004399	nucleotide-binding site [chemical binding]; other site
403833004400	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
403833004401	G1 box; other site
403833004402	GTP/Mg2+ binding site [chemical binding]; other site
403833004403	Switch I region; other site
403833004404	G2 box; other site
403833004405	G3 box; other site
403833004406	Switch II region; other site
403833004407	G4 box; other site
403833004408	G5 box; other site
403833004409	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
403833004410	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
403833004411	active site
403833004412	metal binding site [ion binding]; metal-binding site
403833004413	homotetramer interface [polypeptide binding]; other site
403833004414	Thiamine pyrophosphokinase; Region: TPK; cd07995
403833004415	active site
403833004416	thiamine pyrophosphokinase; Region: thi_PPkinase; TIGR01378
403833004417	dimerization interface [polypeptide binding]; other site
403833004418	thiamine binding site [chemical binding]; other site
403833004419	Uncharacterized conserved protein [Function unknown]; Region: COG0062
403833004420	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
403833004421	putative substrate binding site [chemical binding]; other site
403833004422	putative ATP binding site [chemical binding]; other site
403833004423	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
403833004424	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
403833004425	GDP-binding site [chemical binding]; other site
403833004426	ACT binding site; other site
403833004427	IMP binding site; other site
403833004428	Predicted SPOUT methyltransferase; Region: SPOUT_MTase; pfam02590
403833004429	Formiminotransferase domain, N-terminal subdomain; Region: FTCD_N; pfam07837
403833004430	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
403833004431	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
403833004432	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
403833004433	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
403833004434	active site
403833004435	purine nucleoside phosphorylase; Provisional; Region: PRK08202
403833004436	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
403833004437	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
403833004438	N-acetyl-D-glucosamine binding site [chemical binding]; other site
403833004439	catalytic residue [active]
403833004440	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
403833004441	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
403833004442	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
403833004443	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
403833004444	FliG C-terminal domain; Region: FliG_C; pfam01706
403833004445	F0F1 ATP synthase subunit delta; Provisional; Region: PRK13428
403833004446	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
403833004447	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
403833004448	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
403833004449	Walker A motif/ATP binding site; other site
403833004450	Walker B motif; other site
403833004451	ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175
403833004452	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
403833004453	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833004454	dimer interface [polypeptide binding]; other site
403833004455	conserved gate region; other site
403833004456	putative PBP binding loops; other site
403833004457	ABC-ATPase subunit interface; other site
403833004458	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
403833004459	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833004460	dimer interface [polypeptide binding]; other site
403833004461	conserved gate region; other site
403833004462	putative PBP binding loops; other site
403833004463	ABC-ATPase subunit interface; other site
403833004464	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
403833004465	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
403833004466	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
403833004467	bacterial Hfq-like; Region: Hfq; cd01716
403833004468	hexamer interface [polypeptide binding]; other site
403833004469	Sm1 motif; other site
403833004470	RNA binding site [nucleotide binding]; other site
403833004471	Sm2 motif; other site
403833004472	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
403833004473	Peptidase family M23; Region: Peptidase_M23; pfam01551
403833004474	S-adenosylmethionine synthetase; Validated; Region: PRK05250
403833004475	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
403833004476	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
403833004477	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
403833004478	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
403833004479	Putative methyltransferase; Region: Methyltransf_4; cl17290
403833004480	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
403833004481	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
403833004482	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
403833004483	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
403833004484	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
403833004485	minor groove reading motif; other site
403833004486	helix-hairpin-helix signature motif; other site
403833004487	substrate binding pocket [chemical binding]; other site
403833004488	active site
403833004489	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
403833004490	competence damage-inducible protein A; Provisional; Region: PRK00549
403833004491	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
403833004492	putative MPT binding site; other site
403833004493	Competence-damaged protein; Region: CinA; pfam02464
403833004494	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
403833004495	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
403833004496	putative binding surface; other site
403833004497	active site
403833004498	P2 response regulator binding domain; Region: P2; pfam07194
403833004499	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
403833004500	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
403833004501	ATP binding site [chemical binding]; other site
403833004502	Mg2+ binding site [ion binding]; other site
403833004503	G-X-G motif; other site
403833004504	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
403833004505	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
403833004506	Response regulator receiver domain; Region: Response_reg; pfam00072
403833004507	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
403833004508	active site
403833004509	phosphorylation site [posttranslational modification]
403833004510	intermolecular recognition site; other site
403833004511	dimerization interface [polypeptide binding]; other site
403833004512	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
403833004513	Bacterial export proteins, family 3; Region: Bac_export_3; pfam01313
403833004514	Bacterial export proteins, family 1; Region: Bac_export_1; cl00734
403833004515	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
403833004516	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
403833004517	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
403833004518	FHIPEP family; Region: FHIPEP; pfam00771
403833004519	flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703
403833004520	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
403833004521	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
403833004522	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
403833004523	c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581
403833004524	Flagellar protein YcgR; Region: YcgR_2; pfam12945
403833004525	PilZ domain; Region: PilZ; pfam07238
403833004526	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
403833004527	CheC-like family; Region: CheC; pfam04509
403833004528	RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479
403833004529	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
403833004530	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
403833004531	DNA binding residues [nucleotide binding]
403833004532	CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559
403833004533	DEAD-like helicases superfamily; Region: DEXDc; smart00487
403833004534	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
403833004535	ATP binding site [chemical binding]; other site
403833004536	putative Mg++ binding site [ion binding]; other site
403833004537	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
403833004538	nucleotide binding region [chemical binding]; other site
403833004539	ATP-binding site [chemical binding]; other site
403833004540	TRCF domain; Region: TRCF; pfam03461
403833004541	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
403833004542	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
403833004543	trmE is a tRNA modification GTPase; Region: trmE; cd04164
403833004544	G1 box; other site
403833004545	GTP/Mg2+ binding site [chemical binding]; other site
403833004546	Switch I region; other site
403833004547	G2 box; other site
403833004548	Switch II region; other site
403833004549	G3 box; other site
403833004550	G4 box; other site
403833004551	G5 box; other site
403833004552	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
403833004553	S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887
403833004554	Uncharacterized conserved protein [Function unknown]; Region: COG1739
403833004555	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
403833004556	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
403833004557	DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14962
403833004558	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
403833004559	Walker A motif; other site
403833004560	ATP binding site [chemical binding]; other site
403833004561	Walker B motif; other site
403833004562	arginine finger; other site
403833004563	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
403833004564	Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048
403833004565	spore photoproduct lyase; Region: photo_TT_lyase; cl15393
403833004566	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
403833004567	spermidine synthase; Provisional; Region: PRK00811
403833004568	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
403833004569	S-adenosylmethionine binding site [chemical binding]; other site
403833004570	S-adenosylmethionine decarboxylase; Region: AdoMet_dc; cl00687
403833004571	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
403833004572	non-specific DNA binding site [nucleotide binding]; other site
403833004573	salt bridge; other site
403833004574	sequence-specific DNA binding site [nucleotide binding]; other site
403833004575	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
403833004576	rod shape-determining protein MreB; Provisional; Region: PRK13930
403833004577	MreB and similar proteins; Region: MreB_like; cd10225
403833004578	nucleotide binding site [chemical binding]; other site
403833004579	Mg binding site [ion binding]; other site
403833004580	putative protofilament interaction site [polypeptide binding]; other site
403833004581	RodZ interaction site [polypeptide binding]; other site
403833004582	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
403833004583	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
403833004584	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
403833004585	GIY-YIG domain of hypothetical proteins from archaea and their bacterial homologs; Region: GIY-YIG_COG1833; cd10441
403833004586	GIY-YIG motif/motif A; other site
403833004587	putative active site [active]
403833004588	putative metal binding site [ion binding]; other site
403833004589	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
403833004590	AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019
403833004591	NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976
403833004592	catalytic residues [active]
403833004593	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
403833004594	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
403833004595	active site
403833004596	catalytic site [active]
403833004597	Domon-like ligand-binding domains; Region: DOMON_like; cl14783
403833004598	putative ligand binding site [chemical binding]; other site
403833004599	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
403833004600	30S subunit binding site; other site
403833004601	Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198
403833004602	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
403833004603	ATP binding site [chemical binding]; other site
403833004604	putative Mg++ binding site [ion binding]; other site
403833004605	N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859
403833004606	glycogen binding site [chemical binding]; other site
403833004607	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
403833004608	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
403833004609	active site
403833004610	homodimer interface [polypeptide binding]; other site
403833004611	catalytic site [active]
403833004612	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
403833004613	Walker A motif; other site
403833004614	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
403833004615	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
403833004616	Uridine monophosphate kinase_like (UMPK_like) is a family of proteins highly similar to the uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK); Region: UMPK_like; cd02028
403833004617	active site
403833004618	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
403833004619	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833004620	dimer interface [polypeptide binding]; other site
403833004621	conserved gate region; other site
403833004622	putative PBP binding loops; other site
403833004623	ABC-ATPase subunit interface; other site
403833004624	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
403833004625	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833004626	dimer interface [polypeptide binding]; other site
403833004627	conserved gate region; other site
403833004628	putative PBP binding loops; other site
403833004629	ABC-ATPase subunit interface; other site
403833004630	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
403833004631	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
403833004632	oxaloacetate decarboxylase; Provisional; Region: PRK14041
403833004633	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
403833004634	active site
403833004635	catalytic residues [active]
403833004636	metal binding site [ion binding]; metal-binding site
403833004637	homodimer binding site [polypeptide binding]; other site
403833004638	QueT transporter; Region: QueT; pfam06177
403833004639	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
403833004640	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
403833004641	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
403833004642	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
403833004643	Coenzyme A binding pocket [chemical binding]; other site
403833004644	bifunctional phosphoglycerate kinase/triosephosphate isomerase; Provisional; Region: PRK13962
403833004645	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
403833004646	substrate binding site [chemical binding]; other site
403833004647	hinge regions; other site
403833004648	ADP binding site [chemical binding]; other site
403833004649	catalytic site [active]
403833004650	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
403833004651	substrate binding site [chemical binding]; other site
403833004652	dimer interface [polypeptide binding]; other site
403833004653	catalytic triad [active]
403833004654	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
403833004655	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; pfam00044
403833004656	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
403833004657	YbaB/EbfC DNA-binding family; Region: YbaB_DNA_bd; cl00494
403833004658	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3864
403833004659	Putative metallopeptidase domain; Region: DUF2201_N; pfam13203
403833004660	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
403833004661	MoxR-like ATPases [General function prediction only]; Region: COG0714
403833004662	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
403833004663	Walker A motif; other site
403833004664	ATP binding site [chemical binding]; other site
403833004665	Walker B motif; other site
403833004666	arginine finger; other site
403833004667	ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757
403833004668	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
403833004669	homodimer interface [polypeptide binding]; other site
403833004670	oligonucleotide binding site [chemical binding]; other site
403833004671	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
403833004672	putative active site [active]
403833004673	catalytic residue [active]
403833004674	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
403833004675	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
403833004676	5S rRNA interface [nucleotide binding]; other site
403833004677	CTC domain interface [polypeptide binding]; other site
403833004678	L16 interface [polypeptide binding]; other site
403833004679	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
403833004680	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
403833004681	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
403833004682	active site
403833004683	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14357
403833004684	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
403833004685	Substrate binding site; other site
403833004686	Mg++ binding site; other site
403833004687	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
403833004688	active site
403833004689	substrate binding site [chemical binding]; other site
403833004690	CoA binding site [chemical binding]; other site
403833004691	Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632
403833004692	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
403833004693	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
403833004694	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
403833004695	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
403833004696	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
403833004697	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
403833004698	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
403833004699	active site
403833004700	HIGH motif; other site
403833004701	nucleotide binding site [chemical binding]; other site
403833004702	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
403833004703	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
403833004704	active site
403833004705	KMSKS motif; other site
403833004706	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
403833004707	tRNA binding surface [nucleotide binding]; other site
403833004708	anticodon binding site; other site
403833004709	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
403833004710	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
403833004711	putative substrate translocation pore; other site
403833004712	Major Facilitator Superfamily; Region: MFS_1; pfam07690
403833004713	AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335
403833004714	AMMECR1; Region: AMMECR1; pfam01871
403833004715	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
403833004716	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
403833004717	FeS/SAM binding site; other site
403833004718	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
403833004719	ApbE family; Region: ApbE; pfam02424
403833004720	N-Utilization Substance G (NusG) N terminal (NGN) insert and Lin0431 are part of DUF1312; Region: DUF1312; cd09846
403833004721	Heptaprenyl diphosphate synthase component I; Region: Hpre_diP_synt_I; pfam07456
403833004722	Maf-like protein; Region: Maf; pfam02545
403833004723	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
403833004724	active site
403833004725	dimer interface [polypeptide binding]; other site
403833004726	hypothetical protein; Reviewed; Region: PRK00024
403833004727	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
403833004728	MPN+ (JAMM) motif; other site
403833004729	Zinc-binding site [ion binding]; other site
403833004730	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
403833004731	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
403833004732	homotetramer interface [polypeptide binding]; other site
403833004733	ligand binding site [chemical binding]; other site
403833004734	catalytic site [active]
403833004735	NAD binding site [chemical binding]; other site
403833004736	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
403833004737	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
403833004738	dimer interface [polypeptide binding]; other site
403833004739	active site
403833004740	glycine-pyridoxal phosphate binding site [chemical binding]; other site
403833004741	folate binding site [chemical binding]; other site
403833004742	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
403833004743	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
403833004744	pyridoxal 5'-phosphate binding site [chemical binding]; other site
403833004745	homodimer interface [polypeptide binding]; other site
403833004746	catalytic residue [active]
403833004747	butyrate kinase; Provisional; Region: PRK03011
403833004748	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
403833004749	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
403833004750	nucleotide binding site [chemical binding]; other site
403833004751	Acetokinase family; Region: Acetate_kinase; cl17229
403833004752	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
403833004753	Ferredoxin [Energy production and conversion]; Region: COG1146
403833004754	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
403833004755	2-ketoisovalerate ferredoxin reductase; Validated; Region: PRK07119
403833004756	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
403833004757	dimer interface [polypeptide binding]; other site
403833004758	PYR/PP interface [polypeptide binding]; other site
403833004759	TPP binding site [chemical binding]; other site
403833004760	substrate binding site [chemical binding]; other site
403833004761	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, beta subunit [Energy production and conversion]; Region: PorB; COG1013
403833004762	Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375
403833004763	TPP-binding site [chemical binding]; other site
403833004764	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
403833004765	2-oxoglutarate ferredoxin oxidoreductase subunit gamma; Validated; Region: PRK08537
403833004766	UGMP family protein; Validated; Region: PRK09604
403833004767	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
403833004768	Carbamoyltransferase; Region: CmcH_NodU; pfam02543
403833004769	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
403833004770	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
403833004771	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
403833004772	Walker A motif; other site
403833004773	ATP binding site [chemical binding]; other site
403833004774	Walker B motif; other site
403833004775	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
403833004776	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
403833004777	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
403833004778	dimer interface [polypeptide binding]; other site
403833004779	pyridoxal 5'-phosphate binding site [chemical binding]; other site
403833004780	catalytic residue [active]
403833004781	serine O-acetyltransferase; Region: cysE; TIGR01172
403833004782	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
403833004783	trimer interface [polypeptide binding]; other site
403833004784	active site
403833004785	substrate binding site [chemical binding]; other site
403833004786	CoA binding site [chemical binding]; other site
403833004787	DNA polymerase III PolC; Validated; Region: polC; PRK00448
403833004788	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
403833004789	generic binding surface II; other site
403833004790	generic binding surface I; other site
403833004791	Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102
403833004792	active site
403833004793	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
403833004794	active site
403833004795	catalytic site [active]
403833004796	substrate binding site [chemical binding]; other site
403833004797	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
403833004798	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
403833004799	active site
403833004800	putative DNA-binding cleft [nucleotide binding]; other site
403833004801	dimer interface [polypeptide binding]; other site
403833004802	Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011
403833004803	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
403833004804	Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087
403833004805	active site
403833004806	Flagellin-specific chaperone FliS [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliS; COG1516
403833004807	Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197
403833004808	Predicted amidohydrolase [General function prediction only]; Region: COG0388
403833004809	active site
403833004810	catalytic triad [active]
403833004811	dimer interface [polypeptide binding]; other site
403833004812	N-terminal catalytic domain of putative prokaryotic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_1; cd10790
403833004813	active site
403833004814	metal binding site [ion binding]; metal-binding site
403833004815	homodimer interface [polypeptide binding]; other site
403833004816	catalytic site [active]
403833004817	Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536
403833004818	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
403833004819	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833004820	dimer interface [polypeptide binding]; other site
403833004821	conserved gate region; other site
403833004822	putative PBP binding loops; other site
403833004823	ABC-ATPase subunit interface; other site
403833004824	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833004825	dimer interface [polypeptide binding]; other site
403833004826	conserved gate region; other site
403833004827	putative PBP binding loops; other site
403833004828	ABC-ATPase subunit interface; other site
403833004829	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
403833004830	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
403833004831	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
403833004832	Transcriptional regulators [Transcription]; Region: PurR; COG1609
403833004833	ligand binding site [chemical binding]; other site
403833004834	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
403833004835	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
403833004836	active site
403833004837	dimer interface [polypeptide binding]; other site
403833004838	AAA ATPase domain; Region: AAA_15; pfam13175
403833004839	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
403833004840	Walker A/P-loop; other site
403833004841	ATP binding site [chemical binding]; other site
403833004842	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
403833004843	Walker B; other site
403833004844	D-loop; other site
403833004845	H-loop/switch region; other site
403833004846	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
403833004847	putative active site [active]
403833004848	putative metal-binding site [ion binding]; other site
403833004849	thymidine kinase; Provisional; Region: PRK04296
403833004850	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
403833004851	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
403833004852	active site
403833004853	catalytic tetrad [active]
403833004854	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
403833004855	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
403833004856	S-adenosylmethionine binding site [chemical binding]; other site
403833004857	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
403833004858	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
403833004859	Walker A/P-loop; other site
403833004860	ATP binding site [chemical binding]; other site
403833004861	Q-loop/lid; other site
403833004862	ABC transporter signature motif; other site
403833004863	Walker B; other site
403833004864	D-loop; other site
403833004865	H-loop/switch region; other site
403833004866	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
403833004867	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
403833004868	Walker A/P-loop; other site
403833004869	ATP binding site [chemical binding]; other site
403833004870	Q-loop/lid; other site
403833004871	ABC transporter signature motif; other site
403833004872	Walker B; other site
403833004873	D-loop; other site
403833004874	H-loop/switch region; other site
403833004875	excinuclease ABC subunit B; Provisional; Region: PRK05298
403833004876	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
403833004877	ATP binding site [chemical binding]; other site
403833004878	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
403833004879	nucleotide binding region [chemical binding]; other site
403833004880	ATP-binding site [chemical binding]; other site
403833004881	Ultra-violet resistance protein B; Region: UvrB; pfam12344
403833004882	UvrB/uvrC motif; Region: UVR; pfam02151
403833004883	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
403833004884	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
403833004885	dimer interface [polypeptide binding]; other site
403833004886	putative CheW interface [polypeptide binding]; other site
403833004887	GTP-binding protein LepA; Provisional; Region: PRK05433
403833004888	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
403833004889	G1 box; other site
403833004890	putative GEF interaction site [polypeptide binding]; other site
403833004891	GTP/Mg2+ binding site [chemical binding]; other site
403833004892	Switch I region; other site
403833004893	G2 box; other site
403833004894	G3 box; other site
403833004895	Switch II region; other site
403833004896	G4 box; other site
403833004897	G5 box; other site
403833004898	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
403833004899	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
403833004900	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
403833004901	Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912
403833004902	GTP/Mg2+ binding site [chemical binding]; other site
403833004903	G2 box; other site
403833004904	Switch I region; other site
403833004905	G3 box; other site
403833004906	Switch II region; other site
403833004907	G4 box; other site
403833004908	G5 box; other site
403833004909	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
403833004910	ABC-2 type transporter; Region: ABC2_membrane; cl17235
403833004911	Transposase; Region: DEDD_Tnp_IS110; pfam01548
403833004912	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
403833004913	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
403833004914	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
403833004915	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
403833004916	Walker A/P-loop; other site
403833004917	ATP binding site [chemical binding]; other site
403833004918	Q-loop/lid; other site
403833004919	ABC transporter signature motif; other site
403833004920	Walker B; other site
403833004921	D-loop; other site
403833004922	H-loop/switch region; other site
403833004923	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
403833004924	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
403833004925	FtsX-like permease family; Region: FtsX; pfam02687
403833004926	FtsX-like permease family; Region: FtsX; pfam02687
403833004927	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
403833004928	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
403833004929	active site
403833004930	catalytic residues [active]
403833004931	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
403833004932	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
403833004933	FeS/SAM binding site; other site
403833004934	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
403833004935	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
403833004936	Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641
403833004937	FeS/SAM binding site; other site
403833004938	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
403833004939	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
403833004940	glyoxylate reductase; Reviewed; Region: PRK13243
403833004941	dimerization interface [polypeptide binding]; other site
403833004942	ligand binding site [chemical binding]; other site
403833004943	NADP binding site [chemical binding]; other site
403833004944	catalytic site [active]
403833004945	Uncharacterized protein related to Endonuclease III [DNA replication, recombination, and repair]; Region: COG2231
403833004946	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
403833004947	minor groove reading motif; other site
403833004948	helix-hairpin-helix signature motif; other site
403833004949	substrate binding pocket [chemical binding]; other site
403833004950	active site
403833004951	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
403833004952	Zc3h12a-like Ribonuclease NYN domain; Region: RNase_Zc3h12a; pfam11977
403833004953	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
403833004954	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
403833004955	FlaG protein; Region: FlaG; pfam03646
403833004956	tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042
403833004957	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
403833004958	FMN binding site [chemical binding]; other site
403833004959	active site
403833004960	catalytic residues [active]
403833004961	substrate binding site [chemical binding]; other site
403833004962	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
403833004963	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
403833004964	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
403833004965	Walker A/P-loop; other site
403833004966	ATP binding site [chemical binding]; other site
403833004967	Q-loop/lid; other site
403833004968	ABC transporter signature motif; other site
403833004969	Walker B; other site
403833004970	D-loop; other site
403833004971	H-loop/switch region; other site
403833004972	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
403833004973	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
403833004974	Walker A/P-loop; other site
403833004975	ATP binding site [chemical binding]; other site
403833004976	Q-loop/lid; other site
403833004977	ABC transporter signature motif; other site
403833004978	Walker B; other site
403833004979	D-loop; other site
403833004980	H-loop/switch region; other site
403833004981	H+ Antiporter protein; Region: 2A0121; TIGR00900
403833004982	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
403833004983	putative substrate translocation pore; other site
403833004984	AAA domain; Region: AAA_13; pfam13166
403833004985	Eco57I restriction-modification methylase; Region: Eco57I; pfam07669
403833004986	TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950
403833004987	N-terminal putative catalytic domain of uncharacterized HKD family nucleases fused to putative helicases from the Snf2-like family; Region: PLDc_N_Snf2_like; cd09178
403833004988	PLD-like domain; Region: PLDc_2; pfam13091
403833004989	putative homodimer interface [polypeptide binding]; other site
403833004990	putative active site [active]
403833004991	catalytic site [active]
403833004992	DEAD-like helicases superfamily; Region: DEXDc; smart00487
403833004993	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
403833004994	ATP binding site [chemical binding]; other site
403833004995	putative Mg++ binding site [ion binding]; other site
403833004996	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
403833004997	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
403833004998	nucleotide binding region [chemical binding]; other site
403833004999	ATP-binding site [chemical binding]; other site
403833005000	This CD represents a family of iron-molybdenum cluster-binding proteins that includes NifB, NifX, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of the dinitrogenase enzyme.  This...; Region: NifX_NifB; cl00252
403833005001	ERCC4 domain; Region: ERCC4; pfam02732
403833005002	Fructose-1,6-bisphosphatase; Region: FBPase_3; pfam01950
403833005003	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
403833005004	H+ Antiporter protein; Region: 2A0121; TIGR00900
403833005005	putative substrate translocation pore; other site
403833005006	Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220
403833005007	Isochorismatase family; Region: Isochorismatase; pfam00857
403833005008	catalytic triad [active]
403833005009	conserved cis-peptide bond; other site
403833005010	Uncharacterized conserved protein [Function unknown]; Region: COG1434
403833005011	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
403833005012	putative active site [active]
403833005013	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
403833005014	TPR motif; other site
403833005015	TPR repeat; Region: TPR_11; pfam13414
403833005016	binding surface
403833005017	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
403833005018	binding surface
403833005019	Tetratricopeptide repeat; Region: TPR_16; pfam13432
403833005020	TPR motif; other site
403833005021	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
403833005022	Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain  (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464
403833005023	putative dimer interface [polypeptide binding]; other site
403833005024	CAAX protease self-immunity; Region: Abi; pfam02517
403833005025	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
403833005026	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
403833005027	transmembrane helices; other site
403833005028	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
403833005029	Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the...; Region: P_permease; cd01116
403833005030	transmembrane helices; other site
403833005031	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
403833005032	Metallo-dependent hydrolases, subgroup C is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_C; cd01309
403833005033	active site
403833005034	Threonine dehydrogenase; Region: TDH; cd05281
403833005035	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
403833005036	structural Zn binding site [ion binding]; other site
403833005037	catalytic Zn binding site [ion binding]; other site
403833005038	tetramer interface [polypeptide binding]; other site
403833005039	NADP binding site [chemical binding]; other site
403833005040	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
403833005041	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
403833005042	substrate-cofactor binding pocket; other site
403833005043	pyridoxal 5'-phosphate binding site [chemical binding]; other site
403833005044	catalytic residue [active]
403833005045	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
403833005046	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
403833005047	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
403833005048	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
403833005049	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
403833005050	active site
403833005051	dimer interface [polypeptide binding]; other site
403833005052	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
403833005053	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
403833005054	dimer interface [polypeptide binding]; other site
403833005055	active site
403833005056	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
403833005057	dimer interface [polypeptide binding]; other site
403833005058	active site
403833005059	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
403833005060	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
403833005061	DNA-binding site [nucleotide binding]; DNA binding site
403833005062	UTRA domain; Region: UTRA; pfam07702
403833005063	macrophage migration inhibition factor-like protein; Provisional; Region: PTZ00397
403833005064	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
403833005065	Transposase; Region: DDE_Tnp_ISL3; pfam01610
403833005066	Transposase; Region: DEDD_Tnp_IS110; pfam01548
403833005067	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
403833005068	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
403833005069	H+ Antiporter protein; Region: 2A0121; TIGR00900
403833005070	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
403833005071	putative substrate translocation pore; other site
403833005072	radical SAM/SPASM domain Clo7bot peptide maturase; Region: rSAM_Clo7bot; TIGR04334
403833005073	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
403833005074	Radical SAM superfamily; Region: Radical_SAM; pfam04055
403833005075	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
403833005076	FeS/SAM binding site; other site
403833005077	Domain of unknown function (DUF4008); Region: DUF4008; pfam13186
403833005078	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
403833005079	Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813
403833005080	Zn binding site [ion binding]; other site
403833005081	Zn binding site [ion binding]; other site
403833005082	Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309
403833005083	Major Facilitator Superfamily; Region: MFS_1; pfam07690
403833005084	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
403833005085	putative substrate translocation pore; other site
403833005086	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
403833005087	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
403833005088	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
403833005089	Walker A/P-loop; other site
403833005090	ATP binding site [chemical binding]; other site
403833005091	Q-loop/lid; other site
403833005092	ABC transporter signature motif; other site
403833005093	Walker B; other site
403833005094	D-loop; other site
403833005095	H-loop/switch region; other site
403833005096	Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535
403833005097	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
403833005098	FeS/SAM binding site; other site
403833005099	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
403833005100	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
403833005101	aspartate racemase; Region: asp_race; TIGR00035
403833005102	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
403833005103	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
403833005104	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
403833005105	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
403833005106	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
403833005107	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833005108	dimer interface [polypeptide binding]; other site
403833005109	conserved gate region; other site
403833005110	putative PBP binding loops; other site
403833005111	ABC-ATPase subunit interface; other site
403833005112	Acidic phosphoprotein precursor PCEMA1; Region: PCEMA1; pfam07418
403833005113	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
403833005114	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833005115	dimer interface [polypeptide binding]; other site
403833005116	conserved gate region; other site
403833005117	putative PBP binding loops; other site
403833005118	ABC-ATPase subunit interface; other site
403833005119	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
403833005120	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
403833005121	Walker A/P-loop; other site
403833005122	ATP binding site [chemical binding]; other site
403833005123	Q-loop/lid; other site
403833005124	ABC transporter signature motif; other site
403833005125	Walker B; other site
403833005126	D-loop; other site
403833005127	H-loop/switch region; other site
403833005128	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
403833005129	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
403833005130	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
403833005131	Walker A/P-loop; other site
403833005132	ATP binding site [chemical binding]; other site
403833005133	Q-loop/lid; other site
403833005134	ABC transporter signature motif; other site
403833005135	Walker B; other site
403833005136	D-loop; other site
403833005137	H-loop/switch region; other site
403833005138	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
403833005139	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246
403833005140	homoserine kinase; Provisional; Region: PRK01212
403833005141	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
403833005142	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
403833005143	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
403833005144	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
403833005145	DNA binding residues [nucleotide binding]
403833005146	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
403833005147	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
403833005148	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
403833005149	NAD(P) binding site [chemical binding]; other site
403833005150	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
403833005151	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
403833005152	pyridoxal 5'-phosphate binding site [chemical binding]; other site
403833005153	homodimer interface [polypeptide binding]; other site
403833005154	catalytic residue [active]
403833005155	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
403833005156	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
403833005157	active site
403833005158	catalytic residues [active]
403833005159	metal binding site [ion binding]; metal-binding site
403833005160	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
403833005161	Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445
403833005162	tartrate dehydrogenase; Region: TTC; TIGR02089
403833005163	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
403833005164	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
403833005165	substrate binding site [chemical binding]; other site
403833005166	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
403833005167	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
403833005168	substrate binding site [chemical binding]; other site
403833005169	ligand binding site [chemical binding]; other site
403833005170	2-isopropylmalate synthase; Validated; Region: PRK00915
403833005171	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
403833005172	active site
403833005173	catalytic residues [active]
403833005174	metal binding site [ion binding]; metal-binding site
403833005175	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
403833005176	ketol-acid reductoisomerase; Provisional; Region: PRK05479
403833005177	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
403833005178	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
403833005179	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
403833005180	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
403833005181	putative valine binding site [chemical binding]; other site
403833005182	dimer interface [polypeptide binding]; other site
403833005183	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
403833005184	acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048
403833005185	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
403833005186	PYR/PP interface [polypeptide binding]; other site
403833005187	dimer interface [polypeptide binding]; other site
403833005188	TPP binding site [chemical binding]; other site
403833005189	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
403833005190	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
403833005191	TPP-binding site [chemical binding]; other site
403833005192	dimer interface [polypeptide binding]; other site
403833005193	dihydroxy-acid dehydratase; Provisional; Region: PRK00911
403833005194	Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077
403833005195	Prephenate dehydratase; Region: PDT; pfam00800
403833005196	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
403833005197	putative L-Phe binding site [chemical binding]; other site
403833005198	Predicted esterase [General function prediction only]; Region: COG0627
403833005199	sedoheptulokinase-like proteins; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_SHK_like; cd07777
403833005200	putative N- and C-terminal domain interface [polypeptide binding]; other site
403833005201	D-xylulose kinase; Region: XylB; TIGR01312
403833005202	putative active site [active]
403833005203	MgATP binding site [chemical binding]; other site
403833005204	catalytic site [active]
403833005205	metal binding site [ion binding]; metal-binding site
403833005206	putative carbohydrate binding site [chemical binding]; other site
403833005207	Transcriptional regulators [Transcription]; Region: PurR; COG1609
403833005208	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
403833005209	DNA binding site [nucleotide binding]
403833005210	domain linker motif; other site
403833005211	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
403833005212	dimerization interface [polypeptide binding]; other site
403833005213	ligand binding site [chemical binding]; other site
403833005214	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_2; cd06310
403833005215	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
403833005216	putative ligand binding site [chemical binding]; other site
403833005217	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
403833005218	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
403833005219	Walker A/P-loop; other site
403833005220	ATP binding site [chemical binding]; other site
403833005221	Q-loop/lid; other site
403833005222	ABC transporter signature motif; other site
403833005223	Walker B; other site
403833005224	D-loop; other site
403833005225	H-loop/switch region; other site
403833005226	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
403833005227	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
403833005228	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
403833005229	TM-ABC transporter signature motif; other site
403833005230	RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809
403833005231	Class I aldolases; Region: Aldolase_Class_I; cl17187
403833005232	catalytic residue [active]
403833005233	Membrane transport protein; Region: Mem_trans; cl09117
403833005234	DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014
403833005235	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
403833005236	dimerization interface [polypeptide binding]; other site
403833005237	ligand binding site [chemical binding]; other site
403833005238	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
403833005239	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
403833005240	dimerization interface [polypeptide binding]; other site
403833005241	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
403833005242	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
403833005243	dimer interface [polypeptide binding]; other site
403833005244	putative CheW interface [polypeptide binding]; other site
403833005245	L-fucose isomerase and related proteins [Carbohydrate transport and metabolism]; Region: FucI; COG2407
403833005246	L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578
403833005247	hexamer (dimer of trimers) interface [polypeptide binding]; other site
403833005248	substrate binding site [chemical binding]; other site
403833005249	trimer interface [polypeptide binding]; other site
403833005250	Mn binding site [ion binding]; other site
403833005251	Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070
403833005252	uncharacterized xylulose kinase-like proteins; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_XK_like_1; cd07804
403833005253	N- and C-terminal domain interface [polypeptide binding]; other site
403833005254	putative active site [active]
403833005255	MgATP binding site [chemical binding]; other site
403833005256	catalytic site [active]
403833005257	metal binding site [ion binding]; metal-binding site
403833005258	putative xylulose binding site [chemical binding]; other site
403833005259	putative homodimer interface [polypeptide binding]; other site
403833005260	BadF/BadG/BcrA/BcrD ATPase family; Region: BcrAD_BadFG; cl17271
403833005261	Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924
403833005262	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
403833005263	nucleotide binding site [chemical binding]; other site
403833005264	CoA enzyme activase uncharacterized domain (DUF2229); Region: DUF2229; pfam09989
403833005265	2-hydroxyglutaryl-CoA dehydratase, D-component; Region: HGD-D; pfam06050
403833005266	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3581
403833005267	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cl00065
403833005268	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
403833005269	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
403833005270	S-adenosylmethionine binding site [chemical binding]; other site
403833005271	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
403833005272	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
403833005273	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
403833005274	SLBB domain; Region: SLBB; pfam10531
403833005275	TPR repeat; Region: TPR_11; pfam13414
403833005276	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
403833005277	binding surface
403833005278	TPR motif; other site
403833005279	DNA polymerase III DnaE; Validated; Region: dnaE; PRK07135
403833005280	Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; pfam02660
403833005281	GTP-binding protein Der; Reviewed; Region: PRK00093
403833005282	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
403833005283	G1 box; other site
403833005284	GTP/Mg2+ binding site [chemical binding]; other site
403833005285	Switch I region; other site
403833005286	G2 box; other site
403833005287	Switch II region; other site
403833005288	G3 box; other site
403833005289	G4 box; other site
403833005290	G5 box; other site
403833005291	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
403833005292	G1 box; other site
403833005293	GTP/Mg2+ binding site [chemical binding]; other site
403833005294	Switch I region; other site
403833005295	G2 box; other site
403833005296	G3 box; other site
403833005297	Switch II region; other site
403833005298	G4 box; other site
403833005299	G5 box; other site
403833005300	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
403833005301	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
403833005302	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164
403833005303	RNA binding site [nucleotide binding]; other site
403833005304	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cd00164
403833005305	RNA binding site [nucleotide binding]; other site
403833005306	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
403833005307	RNA binding site [nucleotide binding]; other site
403833005308	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
403833005309	RNA binding site [nucleotide binding]; other site
403833005310	LytB protein; Region: LYTB; cl00507
403833005311	(E)-4-hydroxy-3-methyl-but-2-enyl pyrophosphate reductase (IPP and DMAPP forming); Region: ispH_lytB; TIGR00216
403833005312	cytidylate kinase; Provisional; Region: cmk; PRK00023
403833005313	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
403833005314	CMP-binding site; other site
403833005315	The sites determining sugar specificity; other site
403833005316	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
403833005317	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
403833005318	dimer interface [polypeptide binding]; other site
403833005319	anticodon binding site; other site
403833005320	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
403833005321	homodimer interface [polypeptide binding]; other site
403833005322	motif 1; other site
403833005323	active site
403833005324	motif 2; other site
403833005325	GAD domain; Region: GAD; pfam02938
403833005326	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
403833005327	motif 3; other site
403833005328	Protein of unknown function DUF91; Region: DUF91; cl00709
403833005329	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675
403833005330	Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323
403833005331	Probable transposase; Region: OrfB_IS605; pfam01385
403833005332	transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766
403833005333	S-layer homology domain; Region: SLH; pfam00395
403833005334	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
403833005335	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
403833005336	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
403833005337	active site
403833005338	HIGH motif; other site
403833005339	nucleotide binding site [chemical binding]; other site
403833005340	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
403833005341	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
403833005342	active site
403833005343	KMSKS motif; other site
403833005344	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
403833005345	tRNA binding surface [nucleotide binding]; other site
403833005346	anticodon binding site; other site
403833005347	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
403833005348	Response regulator receiver domain; Region: Response_reg; pfam00072
403833005349	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
403833005350	active site
403833005351	phosphorylation site [posttranslational modification]
403833005352	intermolecular recognition site; other site
403833005353	dimerization interface [polypeptide binding]; other site
403833005354	GAF domain; Region: GAF_3; pfam13492
403833005355	PAS fold; Region: PAS; pfam00989
403833005356	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
403833005357	putative active site [active]
403833005358	heme pocket [chemical binding]; other site
403833005359	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
403833005360	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
403833005361	dimer interface [polypeptide binding]; other site
403833005362	phosphorylation site [posttranslational modification]
403833005363	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
403833005364	ATP binding site [chemical binding]; other site
403833005365	Mg2+ binding site [ion binding]; other site
403833005366	G-X-G motif; other site
403833005367	ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542
403833005368	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
403833005369	Walker A motif; other site
403833005370	ATP binding site [chemical binding]; other site
403833005371	Walker B motif; other site
403833005372	arginine finger; other site
403833005373	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
403833005374	Walker A motif; other site
403833005375	ATP binding site [chemical binding]; other site
403833005376	Walker B motif; other site
403833005377	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
403833005378	Rubredoxin [Energy production and conversion]; Region: COG1773
403833005379	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
403833005380	iron binding site [ion binding]; other site
403833005381	Superoxide reductase-like (SORL) domain, class II; SORL-domains are present in a family of mononuclear non-heme iron proteins that includes superoxide reductase and desulfoferrodoxin.  Superoxide reductase-like proteins scavenge superoxide anion radicals...; Region: SORL_classII; cd03172
403833005382	non-heme iron binding site [ion binding]; other site
403833005383	tetramer interface [polypeptide binding]; other site
403833005384	Rubrerythrin [Energy production and conversion]; Region: COG1592
403833005385	Rubrerythrin, ferritin-like diiron-binding domain; Region: Rubrerythrin; cd01041
403833005386	binuclear metal center [ion binding]; other site
403833005387	Rubredoxin, Small Modular nonheme iron binding domain containing a [Fe(SCys)4] center, present in rubrerythrin and nigerythrin and detected either N- or C-terminal to such proteins as flavin reductase, NAD(P)H-nitrite reductase, and...; Region: rubredoxin_SM; cd00729
403833005388	iron binding site [ion binding]; other site
403833005389	Heme NO binding; Region: HNOB; pfam07700
403833005390	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
403833005391	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
403833005392	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
403833005393	dimer interface [polypeptide binding]; other site
403833005394	putative CheW interface [polypeptide binding]; other site
403833005395	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215
403833005396	Zn2+ binding site [ion binding]; other site
403833005397	Mg2+ binding site [ion binding]; other site
403833005398	SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057
403833005399	2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563
403833005400	Domain of unknown function (DUF368); Region: DUF368; pfam04018
403833005401	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
403833005402	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
403833005403	active site
403833005404	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
403833005405	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cd02883
403833005406	nudix motif; other site
403833005407	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
403833005408	active site
403833005409	HslU subunit interaction site [polypeptide binding]; other site
403833005410	D-alanyl-alanine synthetase A; Provisional; Region: PRK14571
403833005411	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
403833005412	ATP-grasp domain; Region: ATP-grasp_4; cl17255
403833005413	DNA topoisomerase I; Validated; Region: PRK05582
403833005414	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
403833005415	active site
403833005416	interdomain interaction site; other site
403833005417	putative metal-binding site [ion binding]; other site
403833005418	nucleotide binding site [chemical binding]; other site
403833005419	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
403833005420	domain I; other site
403833005421	DNA binding groove [nucleotide binding]
403833005422	phosphate binding site [ion binding]; other site
403833005423	domain II; other site
403833005424	domain III; other site
403833005425	nucleotide binding site [chemical binding]; other site
403833005426	catalytic site [active]
403833005427	domain IV; other site
403833005428	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
403833005429	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
403833005430	Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481
403833005431	YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492
403833005432	generic binding surface I; other site
403833005433	generic binding surface II; other site
403833005434	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
403833005435	Zn2+ binding site [ion binding]; other site
403833005436	Mg2+ binding site [ion binding]; other site
403833005437	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
403833005438	alanine racemase; Reviewed; Region: alr; PRK00053
403833005439	active site
403833005440	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
403833005441	dimer interface [polypeptide binding]; other site
403833005442	substrate binding site [chemical binding]; other site
403833005443	catalytic residues [active]
403833005444	Predicted amidohydrolase [General function prediction only]; Region: COG0388
403833005445	Pyrococcus horikoshii Ph0642 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Ph0642_like; cd07577
403833005446	putative active site [active]
403833005447	catalytic triad [active]
403833005448	dimer interface [polypeptide binding]; other site
403833005449	putative tetramer interface [polypeptide binding]; other site
403833005450	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
403833005451	Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234
403833005452	nucleotide binding site [chemical binding]; other site
403833005453	NEF interaction site [polypeptide binding]; other site
403833005454	SBD interface [polypeptide binding]; other site
403833005455	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
403833005456	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
403833005457	Coenzyme A binding pocket [chemical binding]; other site
403833005458	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
403833005459	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
403833005460	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
403833005461	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
403833005462	undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase; Region: murG; TIGR01133
403833005463	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
403833005464	active site
403833005465	homodimer interface [polypeptide binding]; other site
403833005466	Bacterial cell division membrane protein [Cell division and chromosome partitioning]; Region: FtsW; COG0772
403833005467	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
403833005468	Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485
403833005469	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
403833005470	active site
403833005471	HIGH motif; other site
403833005472	KMSK motif region; other site
403833005473	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
403833005474	tRNA binding surface [nucleotide binding]; other site
403833005475	anticodon binding site; other site
403833005476	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833005477	dimer interface [polypeptide binding]; other site
403833005478	conserved gate region; other site
403833005479	putative PBP binding loops; other site
403833005480	ABC-ATPase subunit interface; other site
403833005481	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
403833005482	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
403833005483	Walker A/P-loop; other site
403833005484	ATP binding site [chemical binding]; other site
403833005485	Q-loop/lid; other site
403833005486	ABC transporter signature motif; other site
403833005487	Walker B; other site
403833005488	D-loop; other site
403833005489	H-loop/switch region; other site
403833005490	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
403833005491	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833005492	dimer interface [polypeptide binding]; other site
403833005493	conserved gate region; other site
403833005494	putative PBP binding loops; other site
403833005495	ABC-ATPase subunit interface; other site
403833005496	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
403833005497	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
403833005498	substrate binding pocket [chemical binding]; other site
403833005499	membrane-bound complex binding site; other site
403833005500	hinge residues; other site
403833005501	asparagine synthetase A; Reviewed; Region: PRK06462
403833005502	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
403833005503	motif 1; other site
403833005504	dimer interface [polypeptide binding]; other site
403833005505	active site
403833005506	motif 2; other site
403833005507	motif 3; other site
403833005508	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
403833005509	purine monophosphate binding site [chemical binding]; other site
403833005510	dimer interface [polypeptide binding]; other site
403833005511	putative catalytic residues [active]
403833005512	ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525
403833005513	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
403833005514	UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472
403833005515	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
403833005516	Mg++ binding site [ion binding]; other site
403833005517	putative catalytic motif [active]
403833005518	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
403833005519	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
403833005520	active site
403833005521	catalytic tetrad [active]
403833005522	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
403833005523	Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453
403833005524	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
403833005525	active site
403833005526	catalytic tetrad [active]
403833005527	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
403833005528	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
403833005529	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
403833005530	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
403833005531	2-oxoglutarate ferredoxin oxidoreductase subunit alpha; Validated; Region: PRK08659
403833005532	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
403833005533	dimer interface [polypeptide binding]; other site
403833005534	PYR/PP interface [polypeptide binding]; other site
403833005535	TPP binding site [chemical binding]; other site
403833005536	substrate binding site [chemical binding]; other site
403833005537	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
403833005538	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
403833005539	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
403833005540	metal binding site [ion binding]; metal-binding site
403833005541	active site
403833005542	I-site; other site
403833005543	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
403833005544	ZIP Zinc transporter; Region: Zip; pfam02535
403833005545	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
403833005546	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
403833005547	S-adenosylmethionine binding site [chemical binding]; other site
403833005548	Domain of unknown function DUF59; Region: DUF59; cl00941
403833005549	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
403833005550	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
403833005551	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
403833005552	RNA/DNA hybrid binding site [nucleotide binding]; other site
403833005553	active site
403833005554	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
403833005555	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
403833005556	TM-ABC transporter signature motif; other site
403833005557	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
403833005558	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
403833005559	TM-ABC transporter signature motif; other site
403833005560	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
403833005561	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
403833005562	Walker A/P-loop; other site
403833005563	ATP binding site [chemical binding]; other site
403833005564	Q-loop/lid; other site
403833005565	ABC transporter signature motif; other site
403833005566	Walker B; other site
403833005567	D-loop; other site
403833005568	H-loop/switch region; other site
403833005569	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
403833005570	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
403833005571	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
403833005572	ligand binding site [chemical binding]; other site
403833005573	Cysteinyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: CysS; COG0215
403833005574	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156
403833005575	flagellar basal-body rod protein FlgB; Region: FlgB; TIGR01396
403833005576	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
403833005577	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681
403833005578	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
403833005579	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
403833005580	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
403833005581	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
403833005582	MgtE intracellular N domain; Region: MgtE_N; smart00924
403833005583	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
403833005584	Divalent cation transporter; Region: MgtE; pfam01769
403833005585	HDOD domain; Region: HDOD; pfam08668
403833005586	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
403833005587	Zn2+ binding site [ion binding]; other site
403833005588	Mg2+ binding site [ion binding]; other site
403833005589	Ribosome-binding factor A; Region: RBFA; pfam02033
403833005590	tRNA pseudouridine synthase B; Provisional; Region: PRK14124
403833005591	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
403833005592	RNA binding site [nucleotide binding]; other site
403833005593	active site
403833005594	PUA domain; Region: PUA; cl00607
403833005595	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
403833005596	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
403833005597	active site
403833005598	nucleotide binding site [chemical binding]; other site
403833005599	HIGH motif; other site
403833005600	KMSKS motif; other site
403833005601	Riboflavin kinase; Region: Flavokinase; pfam01687
403833005602	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
403833005603	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
403833005604	active site
403833005605	Zn binding site [ion binding]; other site
403833005606	Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618
403833005607	DHH family; Region: DHH; pfam01368
403833005608	FOG: CBS domain [General function prediction only]; Region: COG0517
403833005609	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with an upstream DHH domain which performs a phosphoesterase function and a downstream polyA polymerase domain. CBS is a small domain originally...; Region: CBS_pair_DHH_polyA_Pol_assoc; cd04595
403833005610	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
403833005611	tRNA CCA-pyrophosphorylase; Provisional; Region: PRK13298
403833005612	active site
403833005613	NTP binding site [chemical binding]; other site
403833005614	metal binding triad [ion binding]; metal-binding site
403833005615	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
403833005616	heterotetramer interface [polypeptide binding]; other site
403833005617	active site pocket [active]
403833005618	cleavage site
403833005619	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
403833005620	feedback inhibition sensing region; other site
403833005621	homohexameric interface [polypeptide binding]; other site
403833005622	carbamate kinase; Reviewed; Region: PRK12686
403833005623	nucleotide binding site [chemical binding]; other site
403833005624	N-acetyl-L-glutamate binding site [chemical binding]; other site
403833005625	acetylornithine aminotransferase; Provisional; Region: PRK02627
403833005626	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
403833005627	inhibitor-cofactor binding pocket; inhibition site
403833005628	pyridoxal 5'-phosphate binding site [chemical binding]; other site
403833005629	catalytic residue [active]
403833005630	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
403833005631	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
403833005632	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
403833005633	catalytic site [active]
403833005634	subunit interface [polypeptide binding]; other site
403833005635	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
403833005636	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
403833005637	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
403833005638	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
403833005639	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
403833005640	ATP-grasp domain; Region: ATP-grasp_4; cl17255
403833005641	MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245
403833005642	substrate binding site [chemical binding]; other site
403833005643	argininosuccinate synthase; Provisional; Region: PRK13820
403833005644	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
403833005645	ANP binding site [chemical binding]; other site
403833005646	Substrate Binding Site II [chemical binding]; other site
403833005647	Substrate Binding Site I [chemical binding]; other site
403833005648	argininosuccinate lyase; Provisional; Region: PRK00855
403833005649	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
403833005650	active sites [active]
403833005651	tetramer interface [polypeptide binding]; other site
403833005652	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
403833005653	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
403833005654	trans-homoaconitate synthase; Reviewed; Region: aksA; PRK11858
403833005655	Streptomyces rubellomurinus FrbC and related proteins, catalytic TIM barrel domain; Region: DRE_TIM_NifV; cd07939
403833005656	active site
403833005657	catalytic residues [active]
403833005658	metal binding site [ion binding]; metal-binding site
403833005659	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
403833005660	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
403833005661	substrate binding site [chemical binding]; other site
403833005662	ligand binding site [chemical binding]; other site
403833005663	3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439
403833005664	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
403833005665	substrate binding site [chemical binding]; other site
403833005666	Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473
403833005667	tartrate dehydrogenase; Region: TTC; TIGR02089
403833005668	gamma-glutamyl kinase; Provisional; Region: PRK05429
403833005669	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
403833005670	nucleotide binding site [chemical binding]; other site
403833005671	homotetrameric interface [polypeptide binding]; other site
403833005672	putative phosphate binding site [ion binding]; other site
403833005673	putative allosteric binding site; other site
403833005674	PUA domain; Region: PUA; pfam01472
403833005675	trigger factor; Region: tig; TIGR00115
403833005676	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
403833005677	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
403833005678	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
403833005679	Domain of unknown function (DUF4098); Region: DUF4098; pfam13345
403833005680	Protein of unknown function (DUF2089); Region: DUF2089; pfam09862
403833005681	Alpha amylase catalytic domain found in archaeal and bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_arch_bac_AmyA; cd11313
403833005682	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
403833005683	active site
403833005684	catalytic site [active]
403833005685	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
403833005686	SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881
403833005687	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
403833005688	P loop; other site
403833005689	GTP binding site [chemical binding]; other site
403833005690	Uncharacterized protein conserved in bacteria (DUF2225); Region: DUF2225; pfam09986
403833005691	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1655
403833005692	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
403833005693	Peptidase family M23; Region: Peptidase_M23; pfam01551
403833005694	3D domain; Region: 3D; cl01439
403833005695	Predicted transcriptional regulator [Transcription]; Region: COG1959
403833005696	Transcriptional regulator; Region: Rrf2; pfam02082
403833005697	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
403833005698	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
403833005699	Ligand Binding Site [chemical binding]; other site
403833005700	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
403833005701	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
403833005702	active site
403833005703	(T/H)XGH motif; other site
403833005704	elongation factor Ts; Reviewed; Region: tsf; PRK12332
403833005705	UBA/TS-N domain; Region: UBA; pfam00627
403833005706	Elongation factor TS; Region: EF_TS; pfam00889
403833005707	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
403833005708	putative nucleotide binding site [chemical binding]; other site
403833005709	uridine monophosphate binding site [chemical binding]; other site
403833005710	homohexameric interface [polypeptide binding]; other site
403833005711	enolase; Provisional; Region: eno; PRK00077
403833005712	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
403833005713	dimer interface [polypeptide binding]; other site
403833005714	metal binding site [ion binding]; metal-binding site
403833005715	substrate binding pocket [chemical binding]; other site
403833005716	xanthine permease; Region: pbuX; TIGR03173
403833005717	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
403833005718	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
403833005719	threonine synthase; Validated; Region: PRK06260
403833005720	Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of  threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563
403833005721	homodimer interface [polypeptide binding]; other site
403833005722	pyridoxal 5'-phosphate binding site [chemical binding]; other site
403833005723	catalytic residue [active]
403833005724	peptidase; Reviewed; Region: PRK13004
403833005725	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649
403833005726	putative metal binding site [ion binding]; other site
403833005727	putative dimer interface [polypeptide binding]; other site
403833005728	phenylhydantoinase; Validated; Region: PRK08323
403833005729	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
403833005730	active site
403833005731	probable carbamoyltransferase YgeW; Region: ygeW; TIGR03316
403833005732	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
403833005733	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
403833005734	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
403833005735	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
403833005736	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
403833005737	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
403833005738	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
403833005739	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
403833005740	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
403833005741	XdhC Rossmann domain; Region: XdhC_C; pfam13478
403833005742	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
403833005743	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
403833005744	catalytic loop [active]
403833005745	iron binding site [ion binding]; other site
403833005746	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
403833005747	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
403833005748	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
403833005749	active site
403833005750	putative substrate binding pocket [chemical binding]; other site
403833005751	putative chlorohydrolase/aminohydrolase; Validated; Region: PRK07203
403833005752	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
403833005753	active site
403833005754	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
403833005755	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
403833005756	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
403833005757	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
403833005758	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
403833005759	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
403833005760	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
403833005761	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
403833005762	NTPase; Region: NTPase_1; cl17478
403833005763	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
403833005764	dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037
403833005765	phosphate binding site [ion binding]; other site
403833005766	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
403833005767	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
403833005768	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
403833005769	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
403833005770	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
403833005771	active site
403833005772	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
403833005773	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
403833005774	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
403833005775	Periplasmic binding protein TroA_e.  These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea.  They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142
403833005776	putative ligand binding residues [chemical binding]; other site
403833005777	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
403833005778	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
403833005779	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
403833005780	ABC-ATPase subunit  interface; other site
403833005781	dimer interface [polypeptide binding]; other site
403833005782	putative PBP binding regions; other site
403833005783	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
403833005784	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
403833005785	Walker A/P-loop; other site
403833005786	ATP binding site [chemical binding]; other site
403833005787	Q-loop/lid; other site
403833005788	ABC transporter signature motif; other site
403833005789	Walker B; other site
403833005790	D-loop; other site
403833005791	H-loop/switch region; other site
403833005792	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
403833005793	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
403833005794	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
403833005795	active site
403833005796	catalytic site [active]
403833005797	Predicted nuclease of restriction endonuclease-like fold [General    function prediction only]; Region: COG4804
403833005798	Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865
403833005799	Divergent AAA domain; Region: AAA_4; pfam04326
403833005800	ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749
403833005801	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
403833005802	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
403833005803	Potassium binding sites [ion binding]; other site
403833005804	Cesium cation binding sites [ion binding]; other site
403833005805	5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190
403833005806	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
403833005807	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
403833005808	homodimer interface [polypeptide binding]; other site
403833005809	NADP binding site [chemical binding]; other site
403833005810	substrate binding site [chemical binding]; other site
403833005811	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
403833005812	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
403833005813	pyridoxal 5'-phosphate binding site [chemical binding]; other site
403833005814	homodimer interface [polypeptide binding]; other site
403833005815	catalytic residue [active]
403833005816	Serine dehydratase alpha chain; Region: SDH_alpha; cl12120
403833005817	L-serine deaminase [Amino acid transport and metabolism]; Region: SdaA; COG1760
403833005818	L-serine dehydratase, iron-sulfur-dependent, beta subunit; Region: sda_beta; TIGR00719
403833005819	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
403833005820	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
403833005821	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
403833005822	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
403833005823	active site
403833005824	substrate binding site [chemical binding]; other site
403833005825	metal binding site [ion binding]; metal-binding site
403833005826	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
403833005827	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
403833005828	active site
403833005829	DNA binding site [nucleotide binding]
403833005830	Int/Topo IB signature motif; other site
403833005831	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
403833005832	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
403833005833	D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666
403833005834	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
403833005835	Uncharacterized protein related to the periplasmic component of the Tol biopolymer transport system [Function unknown]; Region: COG4946
403833005836	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
403833005837	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
403833005838	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
403833005839	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
403833005840	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
403833005841	protein binding site [polypeptide binding]; other site
403833005842	Tricorn protease; serine protease family S41; Region: Peptidase_S41_TRI; cd07562
403833005843	Domain interface; other site
403833005844	Peptide binding site; other site
403833005845	Active site tetrad [active]
403833005846	6-phosphofructokinase; Provisional; Region: PRK14072
403833005847	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
403833005848	active site
403833005849	ADP/pyrophosphate binding site [chemical binding]; other site
403833005850	dimerization interface [polypeptide binding]; other site
403833005851	allosteric effector site; other site
403833005852	fructose-1,6-bisphosphate binding site; other site
403833005853	CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cd09652
403833005854	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
403833005855	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
403833005856	Walker A/P-loop; other site
403833005857	ATP binding site [chemical binding]; other site
403833005858	Q-loop/lid; other site
403833005859	ABC transporter signature motif; other site
403833005860	Walker B; other site
403833005861	D-loop; other site
403833005862	H-loop/switch region; other site
403833005863	TOBE domain; Region: TOBE; pfam03459
403833005864	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
403833005865	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
403833005866	Radical SAM superfamily; Region: Radical_SAM; pfam04055
403833005867	FeS/SAM binding site; other site
403833005868	pantothenate kinase; Reviewed; Region: PRK13318
403833005869	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
403833005870	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
403833005871	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
403833005872	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
403833005873	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
403833005874	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
403833005875	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
403833005876	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
403833005877	metal binding site [ion binding]; metal-binding site
403833005878	active site
403833005879	I-site; other site
403833005880	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
403833005881	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
403833005882	purine monophosphate binding site [chemical binding]; other site
403833005883	dimer interface [polypeptide binding]; other site
403833005884	putative catalytic residues [active]
403833005885	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
403833005886	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
403833005887	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
403833005888	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
403833005889	active site
403833005890	substrate binding site [chemical binding]; other site
403833005891	cosubstrate binding site; other site
403833005892	catalytic site [active]
403833005893	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
403833005894	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
403833005895	dimerization interface [polypeptide binding]; other site
403833005896	putative ATP binding site [chemical binding]; other site
403833005897	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_20; cd08519
403833005898	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
403833005899	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
403833005900	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833005901	dimer interface [polypeptide binding]; other site
403833005902	conserved gate region; other site
403833005903	ABC-ATPase subunit interface; other site
403833005904	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
403833005905	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
403833005906	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
403833005907	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
403833005908	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
403833005909	Walker A/P-loop; other site
403833005910	ATP binding site [chemical binding]; other site
403833005911	Q-loop/lid; other site
403833005912	ABC transporter signature motif; other site
403833005913	Walker B; other site
403833005914	D-loop; other site
403833005915	H-loop/switch region; other site
403833005916	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
403833005917	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
403833005918	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
403833005919	Walker A/P-loop; other site
403833005920	ATP binding site [chemical binding]; other site
403833005921	Q-loop/lid; other site
403833005922	ABC transporter signature motif; other site
403833005923	Walker B; other site
403833005924	D-loop; other site
403833005925	H-loop/switch region; other site
403833005926	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
403833005927	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
403833005928	MviN-like protein; Region: MVIN; pfam03023
403833005929	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
403833005930	active site
403833005931	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
403833005932	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
403833005933	putative substrate binding site [chemical binding]; other site
403833005934	putative ATP binding site [chemical binding]; other site
403833005935	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
403833005936	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
403833005937	active site
403833005938	catalytic tetrad [active]
403833005939	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
403833005940	Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647
403833005941	active site
403833005942	motif I; other site
403833005943	motif II; other site
403833005944	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
403833005945	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
403833005946	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105
403833005947	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
403833005948	Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  DHPS, a...; Region: Pterin_binding; cl00219
403833005949	substrate binding pocket [chemical binding]; other site
403833005950	dimer interface [polypeptide binding]; other site
403833005951	inhibitor binding site; inhibition site
403833005952	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
403833005953	B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293
403833005954	B12 binding site [chemical binding]; other site
403833005955	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
403833005956	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
403833005957	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
403833005958	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
403833005959	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
403833005960	active site
403833005961	dimer interface [polypeptide binding]; other site
403833005962	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
403833005963	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
403833005964	active site
403833005965	FMN binding site [chemical binding]; other site
403833005966	substrate binding site [chemical binding]; other site
403833005967	3Fe-4S cluster binding site [ion binding]; other site
403833005968	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
403833005969	domain interface; other site
403833005970	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
403833005971	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
403833005972	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
403833005973	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
403833005974	Nitrogen regulatory protein P-II; Region: P-II; smart00938
403833005975	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
403833005976	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
403833005977	active site
403833005978	dimerization interface [polypeptide binding]; other site
403833005979	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
403833005980	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
403833005981	active site
403833005982	catalytic site [active]
403833005983	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
403833005984	G1P_TT_long represents the long form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_long; cd04189
403833005985	glucose-1-phosphate thymidylylransferase, long form; Region: rmlA_long; TIGR01208
403833005986	substrate binding site; other site
403833005987	metal-binding site
403833005988	Oligomer interface; other site
403833005989	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
403833005990	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
403833005991	CoA binding domain; Region: CoA_binding; smart00881
403833005992	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
403833005993	NAD(P) binding site [chemical binding]; other site
403833005994	homodimer interface [polypeptide binding]; other site
403833005995	substrate binding site [chemical binding]; other site
403833005996	active site
403833005997	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
403833005998	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
403833005999	inhibitor-cofactor binding pocket; inhibition site
403833006000	pyridoxal 5'-phosphate binding site [chemical binding]; other site
403833006001	catalytic residue [active]
403833006002	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
403833006003	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
403833006004	dimer interface [polypeptide binding]; other site
403833006005	motif 1; other site
403833006006	active site
403833006007	motif 2; other site
403833006008	motif 3; other site
403833006009	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
403833006010	anticodon binding site; other site
403833006011	Predicted RNA binding protein (contains ribosomal protein S1 domain) [Translation, ribosomal structure and biogenesis]; Region: VacB; COG1098
403833006012	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
403833006013	RNA binding site [nucleotide binding]; other site
403833006014	Ribosomal protein L31; Region: Ribosomal_L31; pfam01197
403833006015	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at PolC gene; Region: PHP_PolIIIA_POLC; cd07435
403833006016	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
403833006017	active site
403833006018	putative PHP Thumb interface [polypeptide binding]; other site
403833006019	Bacterial DNA polymerase III alpha subunit; Region: DNA_pol3_alpha; pfam07733
403833006020	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
403833006021	binding surface
403833006022	TPR motif; other site
403833006023	TPR repeat; Region: TPR_11; pfam13414
403833006024	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
403833006025	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
403833006026	Methyltransferase domain; Region: Methyltransf_12; pfam08242
403833006027	Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344
403833006028	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
403833006029	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
403833006030	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
403833006031	putative metal binding site; other site
403833006032	Tetratricopeptide repeat; Region: TPR_12; pfam13424
403833006033	glutamate dehydrogenase; Provisional; Region: PRK09414
403833006034	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
403833006035	NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313
403833006036	NAD(P) binding site [chemical binding]; other site
403833006037	endonuclease IV; Provisional; Region: PRK01060
403833006038	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
403833006039	AP (apurinic/apyrimidinic) site pocket; other site
403833006040	DNA interaction; other site
403833006041	Metal-binding active site; metal-binding site
403833006042	MutL protein; Region: MutL; pfam13941
403833006043	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
403833006044	aspartate aminotransferase; Provisional; Region: PRK05764
403833006045	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
403833006046	pyridoxal 5'-phosphate binding site [chemical binding]; other site
403833006047	homodimer interface [polypeptide binding]; other site
403833006048	catalytic residue [active]
403833006049	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
403833006050	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
403833006051	S-adenosylmethionine binding site [chemical binding]; other site
403833006052	UDP-N-acetylmuramoylalanine-D-glutamate ligase [Cell envelope biogenesis, outer membrane]; Region: MurD; COG0771
403833006053	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
403833006054	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
403833006055	phospho-N-acetylmuramoyl-pentapeptide-transferase; Region: mraY; TIGR00445
403833006056	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
403833006057	Mg++ binding site [ion binding]; other site
403833006058	putative catalytic motif [active]
403833006059	putative substrate binding site [chemical binding]; other site
403833006060	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
403833006061	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143
403833006062	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
403833006063	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
403833006064	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
403833006065	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
403833006066	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
403833006067	Transcriptional regulator of heat shock gene [Transcription]; Region: HrcA; COG1420
403833006068	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
403833006069	GrpE; Region: GrpE; pfam01025
403833006070	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
403833006071	dimer interface [polypeptide binding]; other site
403833006072	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
403833006073	chaperone protein DnaJ; Region: DnaJ_bact; TIGR02349
403833006074	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
403833006075	HSP70 interaction site [polypeptide binding]; other site
403833006076	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
403833006077	Zn binding sites [ion binding]; other site
403833006078	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
403833006079	dimer interface [polypeptide binding]; other site
403833006080	Uncharacterized conserved protein [Function unknown]; Region: COG1284
403833006081	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
403833006082	Uncharacterized BCR, YitT family COG1284; Region: DUF161; pfam02588
403833006083	Uncharacterized protein conserved in bacteria (DUF2179); Region: DUF2179; pfam10035
403833006084	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
403833006085	Domain of unknown function DUF21; Region: DUF21; pfam01595
403833006086	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
403833006087	Transporter associated domain; Region: CorC_HlyC; smart01091
403833006088	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
403833006089	active site
403833006090	catalytic motif [active]
403833006091	Zn binding site [ion binding]; other site
403833006092	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
403833006093	dimer interface [polypeptide binding]; other site
403833006094	ADP-ribose binding site [chemical binding]; other site
403833006095	active site
403833006096	nudix motif; other site
403833006097	metal binding site [ion binding]; metal-binding site
403833006098	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
403833006099	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
403833006100	active site
403833006101	HIGH motif; other site
403833006102	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
403833006103	active site
403833006104	KMSKS motif; other site
403833006105	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
403833006106	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
403833006107	active site
403833006108	HIGH motif; other site
403833006109	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
403833006110	KMSKS motif; other site
403833006111	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
403833006112	tRNA binding surface [nucleotide binding]; other site
403833006113	anticodon binding site; other site
403833006114	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
403833006115	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
403833006116	PAS fold; Region: PAS_3; pfam08447
403833006117	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
403833006118	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
403833006119	metal binding site [ion binding]; metal-binding site
403833006120	active site
403833006121	I-site; other site
403833006122	DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629
403833006123	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
403833006124	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
403833006125	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
403833006126	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
403833006127	Predicted metal-binding, possibly nucleic acid-binding protein [General function prediction only]; Region: COG1399
403833006128	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
403833006129	putative phosphate acyltransferase; Provisional; Region: PRK05331
403833006130	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
403833006131	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
403833006132	glutaminase active site [active]
403833006133	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
403833006134	dimer interface [polypeptide binding]; other site
403833006135	active site
403833006136	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
403833006137	dimer interface [polypeptide binding]; other site
403833006138	active site
403833006139	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
403833006140	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
403833006141	rRNA interaction site [nucleotide binding]; other site
403833006142	S8 interaction site; other site
403833006143	putative laminin-1 binding site; other site
403833006144	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14330
403833006145	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
403833006146	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
403833006147	FeS/SAM binding site; other site
403833006148	TRAM domain; Region: TRAM; pfam01938
403833006149	Putative esterase; Region: Esterase; pfam00756
403833006150	Protein of unknown function (DUF3816); Region: DUF3816; pfam12822
403833006151	hypothetical protein; Provisional; Region: PRK09609
403833006152	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
403833006153	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
403833006154	S-adenosylmethionine binding site [chemical binding]; other site
403833006155	Protein of unknown function (DUF501); Region: DUF501; pfam04417
403833006156	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
403833006157	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
403833006158	GIY-YIG motif/motif A; other site
403833006159	active site
403833006160	catalytic site [active]
403833006161	putative DNA binding site [nucleotide binding]; other site
403833006162	metal binding site [ion binding]; metal-binding site
403833006163	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
403833006164	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
403833006165	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
403833006166	active site
403833006167	substrate binding site [chemical binding]; other site
403833006168	metal binding site [ion binding]; metal-binding site
403833006169	tRNA pseudouridine synthase ACD; Provisional; Region: PRK14586
403833006170	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
403833006171	dimerization interface 3.5A [polypeptide binding]; other site
403833006172	active site
403833006173	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
403833006174	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
403833006175	Walker A/P-loop; other site
403833006176	ATP binding site [chemical binding]; other site
403833006177	Q-loop/lid; other site
403833006178	ABC transporter signature motif; other site
403833006179	Walker B; other site
403833006180	D-loop; other site
403833006181	H-loop/switch region; other site
403833006182	[FeFe] hydrogenase H-cluster maturation GTPase HydF; Region: GTP_HydF; TIGR03918
403833006183	E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880
403833006184	G1 box; other site
403833006185	GTP/Mg2+ binding site [chemical binding]; other site
403833006186	Switch I region; other site
403833006187	G2 box; other site
403833006188	Switch II region; other site
403833006189	G3 box; other site
403833006190	G4 box; other site
403833006191	G5 box; other site
403833006192	biotin synthase; Provisional; Region: PRK07094
403833006193	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
403833006194	FeS/SAM binding site; other site
403833006195	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
403833006196	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09613
403833006197	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
403833006198	FeS/SAM binding site; other site
403833006199	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
403833006200	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
403833006201	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
403833006202	Walker A/P-loop; other site
403833006203	ATP binding site [chemical binding]; other site
403833006204	Q-loop/lid; other site
403833006205	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
403833006206	ABC transporter signature motif; other site
403833006207	Walker B; other site
403833006208	D-loop; other site
403833006209	H-loop/switch region; other site
403833006210	sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472
403833006211	This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800
403833006212	putative ADP-binding pocket [chemical binding]; other site
403833006213	PLD-like domain; Region: PLDc_2; pfam13091
403833006214	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
403833006215	putative active site [active]
403833006216	catalytic site [active]
403833006217	Catalytic domain of EDTA-resistant nuclease Nuc, vertebrate phospholipase D6, and similar proteins; Region: PLDc_Nuc_like; cd09116
403833006218	PLD-like domain; Region: PLDc_2; pfam13091
403833006219	putative active site [active]
403833006220	catalytic site [active]
403833006221	NAD synthetase; Provisional; Region: PRK13981
403833006222	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
403833006223	multimer interface [polypeptide binding]; other site
403833006224	active site
403833006225	catalytic triad [active]
403833006226	protein interface 1 [polypeptide binding]; other site
403833006227	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
403833006228	homodimer interface [polypeptide binding]; other site
403833006229	NAD binding pocket [chemical binding]; other site
403833006230	ATP binding pocket [chemical binding]; other site
403833006231	Mg binding site [ion binding]; other site
403833006232	active-site loop [active]
403833006233	This family is most closely related to the oligosaccharide phosphorylase domain family and other unidentified sequences. Oligosaccharide phosphorylase catalyzes the breakdown of oligosaccharides into glucose-1-phosphate units. They are important...; Region: GT1_Glycogen_Phosphorylase_like; cd04299
403833006234	putative homodimer interface [polypeptide binding]; other site
403833006235	putative active site pocket [active]
403833006236	alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094
403833006237	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
403833006238	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08665
403833006239	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
403833006240	active site
403833006241	dimer interface [polypeptide binding]; other site
403833006242	effector binding site; other site
403833006243	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
403833006244	TSCPD domain; Region: TSCPD; pfam12637
403833006245	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
403833006246	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
403833006247	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
403833006248	motif II; other site
403833006249	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725
403833006250	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-B; cd09722
403833006251	Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930
403833006252	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
403833006253	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
403833006254	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
403833006255	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I; cl12040
403833006256	Family of unknown function (DUF694); Region: DUF694; pfam05107
403833006257	CRISPR/Cas system-associated protein Cas8b; Region: Cas8b_I-B; cl09718
403833006258	CRISPR/Cas system-associated protein Cas8b; Region: Cas8b_I-B; cl09718
403833006259	CRISPR associated protein Cas6; Region: Cas_Cas6; pfam01881
403833006260	Domain of unknown function (DUF4213); Region: DUF4213; pfam13938
403833006261	Domain of unknown function (DUF364); Region: DUF364; pfam04016
403833006262	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
403833006263	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
403833006264	homodimer interface [polypeptide binding]; other site
403833006265	Walker A motif; other site
403833006266	ATP binding site [chemical binding]; other site
403833006267	hydroxycobalamin binding site [chemical binding]; other site
403833006268	Walker B motif; other site
403833006269	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
403833006270	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
403833006271	Walker A/P-loop; other site
403833006272	ATP binding site [chemical binding]; other site
403833006273	Q-loop/lid; other site
403833006274	ABC transporter signature motif; other site
403833006275	Walker B; other site
403833006276	D-loop; other site
403833006277	H-loop/switch region; other site
403833006278	Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011
403833006279	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
403833006280	Predicted membrane protein [Function unknown]; Region: COG1288; cl17886
403833006281	Predicted membrane protein [Function unknown]; Region: COG1288; cl17886
403833006282	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_6; cd06233
403833006283	putative active site [active]
403833006284	Zn binding site [ion binding]; other site
403833006285	A subgroup of L-lactate dehydrogenases; Region: LDH_2; cd05292
403833006286	L-lactate dehydrogenase; Region: L-LDH-NAD; TIGR01771
403833006287	NAD binding site [chemical binding]; other site
403833006288	dimer interface [polypeptide binding]; other site
403833006289	substrate binding site [chemical binding]; other site
403833006290	tetramer (dimer of dimers) interface [polypeptide binding]; other site
403833006291	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
403833006292	Protein of unknown function (DUF3298); Region: DUF3298; pfam11738
403833006293	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062
403833006294	FMN binding site [chemical binding]; other site
403833006295	dimer interface [polypeptide binding]; other site
403833006296	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
403833006297	HsdM N-terminal domain; Region: HsdM_N; pfam12161
403833006298	Methyltransferase domain; Region: Methyltransf_26; pfam13659
403833006299	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
403833006300	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
403833006301	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
403833006302	type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348
403833006303	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
403833006304	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
403833006305	ATP binding site [chemical binding]; other site
403833006306	putative Mg++ binding site [ion binding]; other site
403833006307	Protein of unknown function DUF45; Region: DUF45; cl00636
403833006308	putative bifunctional 2-polyprenylphenol hydroxylase/glutamate synthase subunit beta; Provisional; Region: PRK12778
403833006309	FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase-like proteins. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)...; Region: DHOD_e_trans_like1; cd06219
403833006310	FAD binding pocket [chemical binding]; other site
403833006311	FAD binding motif [chemical binding]; other site
403833006312	phosphate binding motif [ion binding]; other site
403833006313	beta-alpha-beta structure motif; other site
403833006314	NAD binding pocket [chemical binding]; other site
403833006315	Iron coordination center [ion binding]; other site
403833006316	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
403833006317	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
403833006318	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
403833006319	S-adenosylmethionine binding site [chemical binding]; other site
403833006320	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
403833006321	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
403833006322	ligand binding site [chemical binding]; other site
403833006323	Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333
403833006324	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
403833006325	Lamin Tail Domain; Region: LTD; pfam00932
403833006326	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
403833006327	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
403833006328	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
403833006329	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
403833006330	active site
403833006331	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK14469
403833006332	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
403833006333	FeS/SAM binding site; other site
403833006334	PASTA domain of PBP2x-like proteins, first repeat. Penicillin-binding proteins (PBPs) are the major targets for beta-lactam antibiotics, like penicillins and cephalosporins. Beta-lactam antibiotics specifically inhibit transpeptidase activity by...; Region: PASTA_Pbp2x-like_1; cd06576
403833006335	PASTA domain. This domain is found at the C-termini of several Penicillin-binding proteins (PBPs) and bacterial serine/threonine kinases. It is a small globular fold consisting of 3 beta-sheets and an alpha-helix. The name PASTA is derived from PBP and...; Region: PASTA; cl02768
403833006336	GTPase RsgA; Reviewed; Region: PRK00098
403833006337	S1_YloQ_GTPase: YloQ GTase family (also known as YjeQ and CpgA), S1-like RNA-binding domain. Proteins in the YloQ GTase family bind the ribosome and have GTPase activity. The precise role of this family is unknown. The protein structure is composed of...; Region: S1_YloQ_GTPase; cd04466
403833006338	RNA binding site [nucleotide binding]; other site
403833006339	homodimer interface [polypeptide binding]; other site
403833006340	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
403833006341	GTPase/Zn-binding domain interface [polypeptide binding]; other site
403833006342	GTP/Mg2+ binding site [chemical binding]; other site
403833006343	G4 box; other site
403833006344	G5 box; other site
403833006345	G1 box; other site
403833006346	Switch I region; other site
403833006347	G2 box; other site
403833006348	G3 box; other site
403833006349	Switch II region; other site
403833006350	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
403833006351	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
403833006352	substrate binding site [chemical binding]; other site
403833006353	hexamer interface [polypeptide binding]; other site
403833006354	metal binding site [ion binding]; metal-binding site
403833006355	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
403833006356	active site
403833006357	dimerization interface [polypeptide binding]; other site
403833006358	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
403833006359	IHF dimer interface [polypeptide binding]; other site
403833006360	IHF - DNA interface [nucleotide binding]; other site
403833006361	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
403833006362	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
403833006363	active site
403833006364	metal binding site [ion binding]; metal-binding site
403833006365	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
403833006366	glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389
403833006367	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
403833006368	Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403
403833006369	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
403833006370	tetramer interface [polypeptide binding]; other site
403833006371	pyridoxal 5'-phosphate binding site [chemical binding]; other site
403833006372	catalytic residue [active]
403833006373	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
403833006374	tetramer interface [polypeptide binding]; other site
403833006375	pyridoxal 5'-phosphate binding site [chemical binding]; other site
403833006376	catalytic residue [active]
403833006377	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
403833006378	metal binding site 2 [ion binding]; metal-binding site
403833006379	putative DNA binding helix; other site
403833006380	metal binding site 1 [ion binding]; metal-binding site
403833006381	dimer interface [polypeptide binding]; other site
403833006382	structural Zn2+ binding site [ion binding]; other site
403833006383	6-phosphofructokinase; Provisional; Region: PRK03202
403833006384	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
403833006385	active site
403833006386	ADP/pyrophosphate binding site [chemical binding]; other site
403833006387	dimerization interface [polypeptide binding]; other site
403833006388	allosteric effector site; other site
403833006389	fructose-1,6-bisphosphate binding site; other site
403833006390	Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469
403833006391	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
403833006392	domain interfaces; other site
403833006393	active site
403833006394	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
403833006395	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
403833006396	Walker A motif; other site
403833006397	ATP binding site [chemical binding]; other site
403833006398	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
403833006399	Walker B motif; other site
403833006400	arginine finger; other site
403833006401	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
403833006402	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
403833006403	TrkA-N domain; Region: TrkA_N; pfam02254
403833006404	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
403833006405	TrkA-C domain; Region: TrkA_C; pfam02080
403833006406	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
403833006407	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
403833006408	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
403833006409	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833006410	dimer interface [polypeptide binding]; other site
403833006411	conserved gate region; other site
403833006412	putative PBP binding loops; other site
403833006413	ABC-ATPase subunit interface; other site
403833006414	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833006415	dimer interface [polypeptide binding]; other site
403833006416	conserved gate region; other site
403833006417	putative PBP binding loops; other site
403833006418	ABC-ATPase subunit interface; other site
403833006419	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
403833006420	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
403833006421	MarR family; Region: MarR_2; pfam12802
403833006422	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
403833006423	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
403833006424	nucleotide binding site [chemical binding]; other site
403833006425	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
403833006426	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
403833006427	dimer interface [polypeptide binding]; other site
403833006428	phosphorylation site [posttranslational modification]
403833006429	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
403833006430	ATP binding site [chemical binding]; other site
403833006431	Mg2+ binding site [ion binding]; other site
403833006432	G-X-G motif; other site
403833006433	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
403833006434	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
403833006435	active site
403833006436	phosphorylation site [posttranslational modification]
403833006437	intermolecular recognition site; other site
403833006438	dimerization interface [polypeptide binding]; other site
403833006439	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
403833006440	DNA binding site [nucleotide binding]
403833006441	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
403833006442	PhoU domain; Region: PhoU; pfam01895
403833006443	PhoU domain; Region: PhoU; pfam01895
403833006444	ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117
403833006445	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
403833006446	Walker A/P-loop; other site
403833006447	ATP binding site [chemical binding]; other site
403833006448	Q-loop/lid; other site
403833006449	ABC transporter signature motif; other site
403833006450	Walker B; other site
403833006451	D-loop; other site
403833006452	H-loop/switch region; other site
403833006453	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
403833006454	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833006455	dimer interface [polypeptide binding]; other site
403833006456	conserved gate region; other site
403833006457	putative PBP binding loops; other site
403833006458	ABC-ATPase subunit interface; other site
403833006459	phosphate ABC transporter, permease protein PstC; Region: phosphate_pstC; TIGR02138
403833006460	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
403833006461	dimer interface [polypeptide binding]; other site
403833006462	conserved gate region; other site
403833006463	putative PBP binding loops; other site
403833006464	ABC-ATPase subunit interface; other site
403833006465	phosphate binding protein; Region: ptsS_2; TIGR02136
403833006466	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
403833006467	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
403833006468	Zn2+ binding site [ion binding]; other site
403833006469	Mg2+ binding site [ion binding]; other site
403833006470	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
403833006471	synthetase active site [active]
403833006472	NTP binding site [chemical binding]; other site
403833006473	metal binding site [ion binding]; metal-binding site
403833006474	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
403833006475	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
403833006476	putative active site [active]
403833006477	dimerization interface [polypeptide binding]; other site
403833006478	putative tRNAtyr binding site [nucleotide binding]; other site
403833006479	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
403833006480	Walker A motif; other site
403833006481	ATP binding site [chemical binding]; other site
403833006482	Walker B motif; other site
403833006483	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
403833006484	binding surface
403833006485	TPR motif; other site
403833006486	Tetratricopeptide repeat; Region: TPR_12; pfam13424
403833006487	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
403833006488	binding surface
403833006489	TPR motif; other site
403833006490	Tetratricopeptide repeat; Region: TPR_12; pfam13424
403833006491	Tetratricopeptide repeat; Region: TPR_12; pfam13424
403833006492	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
403833006493	binding surface
403833006494	TPR motif; other site
403833006495	Tetratricopeptide repeat; Region: TPR_12; pfam13424
403833006496	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
403833006497	binding surface
403833006498	TPR motif; other site
403833006499	Tetratricopeptide repeat; Region: TPR_12; pfam13424
403833006500	Tetratricopeptide repeat; Region: TPR_12; pfam13424
403833006501	Tetratricopeptide repeat; Region: TPR_12; pfam13424
403833006502	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
403833006503	binding surface
403833006504	TPR motif; other site
403833006505	Tetratricopeptide repeat; Region: TPR_12; pfam13424
403833006506	Tetratricopeptide repeat; Region: TPR_12; pfam13424
403833006507	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
403833006508	binding surface
403833006509	TPR motif; other site
403833006510	Tetratricopeptide repeat; Region: TPR_12; pfam13424
403833006511	HD domain; Region: HD_3; cl17350
403833006512	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
403833006513	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
403833006514	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
403833006515	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
403833006516	RIP metalloprotease RseP; Region: TIGR00054
403833006517	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
403833006518	active site
403833006519	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
403833006520	protein binding site [polypeptide binding]; other site
403833006521	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
403833006522	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
403833006523	putative substrate binding region [chemical binding]; other site
403833006524	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
403833006525	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
403833006526	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
403833006527	Protein of unknown function (DUF327); Region: DUF327; pfam03885
403833006528	DNA polymerase III, delta subunit; Region: DNA_pol3_delta2; pfam13177
403833006529	DNA polymerase III subunit delta'; Validated; Region: PRK08485
403833006530	PSP1 C-terminal conserved region; Region: PSP1; cl00770
403833006531	Protein of unknown function (DUF2905); Region: DUF2905; pfam11146
403833006532	transketolase; Reviewed; Region: PRK05899
403833006533	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
403833006534	TPP-binding site [chemical binding]; other site
403833006535	dimer interface [polypeptide binding]; other site
403833006536	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
403833006537	PYR/PP interface [polypeptide binding]; other site
403833006538	dimer interface [polypeptide binding]; other site
403833006539	TPP binding site [chemical binding]; other site
403833006540	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
403833006541	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
403833006542	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
403833006543	dimerization interface [polypeptide binding]; other site
403833006544	active site
403833006545	metal binding site [ion binding]; metal-binding site
403833006546	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
403833006547	dsRNA binding site [nucleotide binding]; other site
403833006548	Uncharacterized homolog of biotin synthetase [Function unknown]; Region: COG1856
403833006549	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
403833006550	FeS/SAM binding site; other site
403833006551	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
403833006552	FeS/SAM binding site; other site
403833006553	Transposase; Region: DEDD_Tnp_IS110; pfam01548
403833006554	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
403833006555	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
403833006556	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
403833006557	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
403833006558	putative active site [active]
403833006559	heme pocket [chemical binding]; other site
403833006560	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
403833006561	Walker A motif; other site
403833006562	ATP binding site [chemical binding]; other site
403833006563	Walker B motif; other site
403833006564	arginine finger; other site
403833006565	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
403833006566	flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473
403833006567	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
403833006568	Low molecular weight phosphatase family; Region: LMWPc; cd00115
403833006569	active site
403833006570	AIR carboxylase; Region: AIRC; smart01001
403833006571	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
403833006572	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
403833006573	ATP binding site [chemical binding]; other site
403833006574	active site
403833006575	substrate binding site [chemical binding]; other site
403833006576	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
403833006577	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
403833006578	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
403833006579	putative active site [active]
403833006580	catalytic triad [active]
403833006581	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
403833006582	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
403833006583	dimerization interface [polypeptide binding]; other site
403833006584	ATP binding site [chemical binding]; other site
403833006585	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
403833006586	dimerization interface [polypeptide binding]; other site
403833006587	ATP binding site [chemical binding]; other site
403833006588	Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319
403833006589	active site