-- dump date 20140619_233518 -- class Genbank::misc_feature -- table misc_feature_note -- id note 391619000001 Initiator Replication protein; Region: Rep_3; pfam01051 391619000002 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 391619000003 ABC1 family; Region: ABC1; pfam03109 391619000004 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 391619000005 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 391619000006 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 391619000007 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391619000008 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391619000009 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 391619000010 dimerization interface [polypeptide binding]; other site 391619000011 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 391619000012 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 391619000013 heme binding site [chemical binding]; other site 391619000014 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 391619000015 heme binding site [chemical binding]; other site 391619000016 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 391619000017 Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640 391619000018 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 391619000019 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391619000020 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391619000021 DNA binding residues [nucleotide binding] 391619000022 Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662 391619000023 Transcriptional regulator; Region: Rrf2; cl17282 391619000024 Rrf2 family protein; Region: rrf2_super; TIGR00738 391619000025 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 391619000026 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 391619000027 heme-binding site [chemical binding]; other site 391619000028 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 391619000029 FAD binding pocket [chemical binding]; other site 391619000030 FAD binding motif [chemical binding]; other site 391619000031 phosphate binding motif [ion binding]; other site 391619000032 beta-alpha-beta structure motif; other site 391619000033 NAD binding pocket [chemical binding]; other site 391619000034 Heme binding pocket [chemical binding]; other site 391619000035 H+ Antiporter protein; Region: 2A0121; TIGR00900 391619000036 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391619000037 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 391619000038 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391619000039 NAD binding site [chemical binding]; other site 391619000040 catalytic residues [active] 391619000041 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391619000042 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391619000043 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 391619000044 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 391619000045 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 391619000046 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391619000047 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391619000048 DNA binding site [nucleotide binding] 391619000049 domain linker motif; other site 391619000050 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 391619000051 ligand binding site [chemical binding]; other site 391619000052 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391619000053 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391619000054 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391619000055 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619000056 dimer interface [polypeptide binding]; other site 391619000057 conserved gate region; other site 391619000058 putative PBP binding loops; other site 391619000059 ABC-ATPase subunit interface; other site 391619000060 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391619000061 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619000062 dimer interface [polypeptide binding]; other site 391619000063 conserved gate region; other site 391619000064 putative PBP binding loops; other site 391619000065 ABC-ATPase subunit interface; other site 391619000066 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391619000067 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 391619000068 Walker A/P-loop; other site 391619000069 ATP binding site [chemical binding]; other site 391619000070 Q-loop/lid; other site 391619000071 ABC transporter signature motif; other site 391619000072 Walker B; other site 391619000073 D-loop; other site 391619000074 H-loop/switch region; other site 391619000075 TOBE domain; Region: TOBE_2; pfam08402 391619000076 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 391619000077 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391619000078 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391619000079 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 391619000080 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391619000081 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391619000082 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 391619000083 dimerization interface [polypeptide binding]; other site 391619000084 NADH dehydrogenase subunit L; Provisional; Region: PRK08168 391619000085 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 391619000086 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 391619000087 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391619000088 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391619000089 non-specific DNA binding site [nucleotide binding]; other site 391619000090 salt bridge; other site 391619000091 sequence-specific DNA binding site [nucleotide binding]; other site 391619000092 Cupin domain; Region: Cupin_2; pfam07883 391619000093 dihydrolipoamide dehydrogenase; Region: lipoamide_DH; TIGR01350 391619000094 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391619000095 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391619000096 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 391619000097 lipoyl synthase; Provisional; Region: PRK05481 391619000098 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391619000099 FeS/SAM binding site; other site 391619000100 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 391619000101 amino acid carrier protein; Region: agcS; TIGR00835 391619000102 glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579 391619000103 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391619000104 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 391619000105 lipoyl attachment site [posttranslational modification]; other site 391619000106 glycine dehydrogenase; Provisional; Region: PRK05367 391619000107 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 391619000108 tetramer interface [polypeptide binding]; other site 391619000109 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391619000110 catalytic residue [active] 391619000111 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 391619000112 tetramer interface [polypeptide binding]; other site 391619000113 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391619000114 catalytic residue [active] 391619000115 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 391619000116 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 391619000117 conserved cys residue [active] 391619000118 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 391619000119 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 391619000120 ligand binding site [chemical binding]; other site 391619000121 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 391619000122 Domain of unknown function (DUF336); Region: DUF336; cl01249 391619000123 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 391619000124 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391619000125 ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604 391619000126 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 391619000127 Walker A/P-loop; other site 391619000128 ATP binding site [chemical binding]; other site 391619000129 Q-loop/lid; other site 391619000130 ABC transporter signature motif; other site 391619000131 Walker B; other site 391619000132 D-loop; other site 391619000133 H-loop/switch region; other site 391619000134 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 391619000135 ABC-ATPase subunit interface; other site 391619000136 dimer interface [polypeptide binding]; other site 391619000137 putative PBP binding regions; other site 391619000138 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 391619000139 ABC-ATPase subunit interface; other site 391619000140 dimer interface [polypeptide binding]; other site 391619000141 putative PBP binding regions; other site 391619000142 ABC-type enterochelin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: CeuA; COG4607 391619000143 Siderophore binding protein FatB. These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140 391619000144 putative ligand binding residues [chemical binding]; other site 391619000145 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 391619000146 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 391619000147 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 391619000148 IucA / IucC family; Region: IucA_IucC; pfam04183 391619000149 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 391619000150 IucA / IucC family; Region: IucA_IucC; pfam04183 391619000151 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 391619000152 acyl-CoA synthetase; Validated; Region: PRK08308 391619000153 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391619000154 acyl-activating enzyme (AAE) consensus motif; other site 391619000155 AMP binding site [chemical binding]; other site 391619000156 active site 391619000157 CoA binding site [chemical binding]; other site 391619000158 acyl carrier protein; Provisional; Region: PRK07639 391619000159 A predicted NlpC/p60-like peptidase; Region: BtrH; pfam14399 391619000160 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 391619000161 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 391619000162 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391619000163 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391619000164 Walker A/P-loop; other site 391619000165 ATP binding site [chemical binding]; other site 391619000166 Q-loop/lid; other site 391619000167 ABC transporter signature motif; other site 391619000168 Walker B; other site 391619000169 D-loop; other site 391619000170 H-loop/switch region; other site 391619000171 Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981 391619000172 Fic family protein [Function unknown]; Region: COG3177 391619000173 Domain of unknown function (DUF4172); Region: DUF4172; pfam13776 391619000174 Fic/DOC family; Region: Fic; pfam02661 391619000175 MarR family; Region: MarR_2; cl17246 391619000176 Autoinducer binding domain; Region: Autoind_bind; pfam03472 391619000177 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391619000178 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391619000179 DNA binding residues [nucleotide binding] 391619000180 dimerization interface [polypeptide binding]; other site 391619000181 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 391619000182 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391619000183 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 391619000184 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 391619000185 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 391619000186 HlyD family secretion protein; Region: HlyD_3; pfam13437 391619000187 MltA-interacting protein MipA; Region: MipA; cl01504 391619000188 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391619000189 dimerization interface [polypeptide binding]; other site 391619000190 putative DNA binding site [nucleotide binding]; other site 391619000191 putative Zn2+ binding site [ion binding]; other site 391619000192 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 391619000193 putative hydrophobic ligand binding site [chemical binding]; other site 391619000194 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391619000195 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391619000196 substrate binding pocket [chemical binding]; other site 391619000197 membrane-bound complex binding site; other site 391619000198 hinge residues; other site 391619000199 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391619000200 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391619000201 dimer interface [polypeptide binding]; other site 391619000202 phosphorylation site [posttranslational modification] 391619000203 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391619000204 ATP binding site [chemical binding]; other site 391619000205 Mg2+ binding site [ion binding]; other site 391619000206 G-X-G motif; other site 391619000207 PRC-barrel domain; Region: PRC; pfam05239 391619000208 ParB-like nuclease domain; Region: ParB; smart00470 391619000209 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 391619000210 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 391619000211 P-loop; other site 391619000212 Magnesium ion binding site [ion binding]; other site 391619000213 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 391619000214 Magnesium ion binding site [ion binding]; other site 391619000215 Replication initiator protein A; Region: RPA; pfam10134 391619000216 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 391619000217 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 391619000218 HlyD family secretion protein; Region: HlyD_3; pfam13437 391619000219 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 391619000220 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391619000221 Walker A/P-loop; other site 391619000222 ATP binding site [chemical binding]; other site 391619000223 Q-loop/lid; other site 391619000224 ABC transporter signature motif; other site 391619000225 Walker B; other site 391619000226 D-loop; other site 391619000227 H-loop/switch region; other site 391619000228 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 391619000229 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391619000230 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391619000231 DNA binding residues [nucleotide binding] 391619000232 dimerization interface [polypeptide binding]; other site 391619000233 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391619000234 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391619000235 DNA binding residues [nucleotide binding] 391619000236 dimerization interface [polypeptide binding]; other site 391619000237 This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818 391619000238 putative ADP-binding pocket [chemical binding]; other site 391619000239 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 391619000240 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 391619000241 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 391619000242 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 391619000243 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391619000244 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391619000245 substrate binding pocket [chemical binding]; other site 391619000246 membrane-bound complex binding site; other site 391619000247 hinge residues; other site 391619000248 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619000249 dimer interface [polypeptide binding]; other site 391619000250 conserved gate region; other site 391619000251 putative PBP binding loops; other site 391619000252 ABC-ATPase subunit interface; other site 391619000253 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 391619000254 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 391619000255 Walker A/P-loop; other site 391619000256 ATP binding site [chemical binding]; other site 391619000257 Q-loop/lid; other site 391619000258 ABC transporter signature motif; other site 391619000259 Walker B; other site 391619000260 D-loop; other site 391619000261 H-loop/switch region; other site 391619000262 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 391619000263 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 391619000264 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 391619000265 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 391619000266 NAD(P) binding site [chemical binding]; other site 391619000267 homodimer interface [polypeptide binding]; other site 391619000268 substrate binding site [chemical binding]; other site 391619000269 active site 391619000270 Bacterial sugar transferase; Region: Bac_transf; pfam02397 391619000271 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391619000272 active site 391619000273 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 391619000274 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 391619000275 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 391619000276 trimer interface [polypeptide binding]; other site 391619000277 active site 391619000278 substrate binding site [chemical binding]; other site 391619000279 CoA binding site [chemical binding]; other site 391619000280 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 391619000281 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 391619000282 substrate binding site; other site 391619000283 tetramer interface; other site 391619000284 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 391619000285 RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321 391619000286 NADP binding site [chemical binding]; other site 391619000287 active site 391619000288 putative substrate binding site [chemical binding]; other site 391619000289 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 391619000290 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 391619000291 NAD binding site [chemical binding]; other site 391619000292 substrate binding site [chemical binding]; other site 391619000293 homodimer interface [polypeptide binding]; other site 391619000294 active site 391619000295 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 391619000296 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 391619000297 active site 391619000298 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 391619000299 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 391619000300 Protein of unknown function (DUF2793); Region: DUF2793; pfam10983 391619000301 Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962 391619000302 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 391619000303 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 391619000304 Substrate binding site; other site 391619000305 Cupin domain; Region: Cupin_2; cl17218 391619000306 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 391619000307 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 391619000308 NADP binding site [chemical binding]; other site 391619000309 active site 391619000310 putative substrate binding site [chemical binding]; other site 391619000311 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 391619000312 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 391619000313 NADP-binding site; other site 391619000314 homotetramer interface [polypeptide binding]; other site 391619000315 substrate binding site [chemical binding]; other site 391619000316 homodimer interface [polypeptide binding]; other site 391619000317 active site 391619000318 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 391619000319 HlyD family secretion protein; Region: HlyD_3; pfam13437 391619000320 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 391619000321 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 391619000322 Walker A/P-loop; other site 391619000323 ATP binding site [chemical binding]; other site 391619000324 Q-loop/lid; other site 391619000325 ABC transporter signature motif; other site 391619000326 Walker B; other site 391619000327 D-loop; other site 391619000328 H-loop/switch region; other site 391619000329 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 391619000330 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 391619000331 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 391619000332 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 391619000333 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 391619000334 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185 391619000335 Probable Catalytic site; other site 391619000336 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 391619000337 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391619000338 UDP-galactopyranose mutase; Region: GLF; pfam03275 391619000339 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 391619000340 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 391619000341 Walker A/P-loop; other site 391619000342 ATP binding site [chemical binding]; other site 391619000343 Q-loop/lid; other site 391619000344 ABC transporter signature motif; other site 391619000345 Walker B; other site 391619000346 D-loop; other site 391619000347 H-loop/switch region; other site 391619000348 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524 391619000349 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 391619000350 ABC-2 type transporter; Region: ABC2_membrane; cl17235 391619000351 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 391619000352 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 391619000353 active site 391619000354 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 391619000355 UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253 391619000356 putative NAD(P) binding site [chemical binding]; other site 391619000357 active site 391619000358 putative substrate binding site [chemical binding]; other site 391619000359 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 391619000360 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 391619000361 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 391619000362 plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454 391619000363 ParB-like nuclease domain; Region: ParBc; cl02129 391619000364 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 391619000365 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 391619000366 P-loop; other site 391619000367 Magnesium ion binding site [ion binding]; other site 391619000368 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 391619000369 Magnesium ion binding site [ion binding]; other site 391619000370 DnaA N-terminal domain; Region: DnaA_N; pfam11638 391619000371 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 391619000372 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391619000373 Walker A motif; other site 391619000374 ATP binding site [chemical binding]; other site 391619000375 Walker B motif; other site 391619000376 arginine finger; other site 391619000377 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 391619000378 DnaA box-binding interface [nucleotide binding]; other site 391619000379 DNA polymerase III subunit beta; Validated; Region: PRK05643 391619000380 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 391619000381 putative DNA binding surface [nucleotide binding]; other site 391619000382 dimer interface [polypeptide binding]; other site 391619000383 beta-clamp/clamp loader binding surface; other site 391619000384 beta-clamp/translesion DNA polymerase binding surface; other site 391619000385 recombination protein F; Reviewed; Region: recF; PRK00064 391619000386 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391619000387 Walker A/P-loop; other site 391619000388 ATP binding site [chemical binding]; other site 391619000389 Q-loop/lid; other site 391619000390 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391619000391 ABC transporter signature motif; other site 391619000392 Walker B; other site 391619000393 D-loop; other site 391619000394 H-loop/switch region; other site 391619000395 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 391619000396 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391619000397 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391619000398 Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525 391619000399 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 391619000400 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 391619000401 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391619000402 Mg2+ binding site [ion binding]; other site 391619000403 G-X-G motif; other site 391619000404 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 391619000405 anchoring element; other site 391619000406 dimer interface [polypeptide binding]; other site 391619000407 ATP binding site [chemical binding]; other site 391619000408 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 391619000409 active site 391619000410 putative metal-binding site [ion binding]; other site 391619000411 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 391619000412 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 391619000413 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391619000414 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391619000415 substrate binding pocket [chemical binding]; other site 391619000416 membrane-bound complex binding site; other site 391619000417 hinge residues; other site 391619000418 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 391619000419 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391619000420 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391619000421 substrate binding pocket [chemical binding]; other site 391619000422 membrane-bound complex binding site; other site 391619000423 hinge residues; other site 391619000424 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 391619000425 LysE type translocator; Region: LysE; cl00565 391619000426 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391619000427 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391619000428 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391619000429 Transcriptional regulators [Transcription]; Region: MarR; COG1846 391619000430 MarR family; Region: MarR_2; pfam12802 391619000431 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391619000432 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 391619000433 Coenzyme A binding pocket [chemical binding]; other site 391619000434 EamA-like transporter family; Region: EamA; pfam00892 391619000435 EamA-like transporter family; Region: EamA; pfam00892 391619000436 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391619000437 Site-specific recombinase XerD [DNA replication, recombination, and repair]; Region: XerD; COG4974 391619000438 active site 391619000439 Int/Topo IB signature motif; other site 391619000440 DNA binding site [nucleotide binding] 391619000441 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391619000442 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 391619000443 DNA binding residues [nucleotide binding] 391619000444 Integrase core domain; Region: rve; pfam00665 391619000445 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 391619000446 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391619000447 Walker A motif; other site 391619000448 ATP binding site [chemical binding]; other site 391619000449 Walker B motif; other site 391619000450 arginine finger; other site 391619000451 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619000452 dimer interface [polypeptide binding]; other site 391619000453 conserved gate region; other site 391619000454 ABC-ATPase subunit interface; other site 391619000455 Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011 391619000456 agmatinase; Region: agmatinase; TIGR01230 391619000457 active site 391619000458 metal binding site [ion binding]; metal-binding site 391619000459 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 391619000460 agmatinase; Region: agmatinase; TIGR01230 391619000461 oligomer interface [polypeptide binding]; other site 391619000462 putative active site [active] 391619000463 Mn binding site [ion binding]; other site 391619000464 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 391619000465 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 391619000466 putative active site [active] 391619000467 putative PHP Thumb interface [polypeptide binding]; other site 391619000468 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 391619000469 generic binding surface I; other site 391619000470 generic binding surface II; other site 391619000471 DNA Polymerase Y-family; Region: PolY_like; cd03468 391619000472 Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389 391619000473 DNA binding site [nucleotide binding] 391619000474 Uncharacterized conserved protein [Function unknown]; Region: COG4544 391619000475 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 391619000476 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 391619000477 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 391619000478 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391619000479 FeS/SAM binding site; other site 391619000480 HemN C-terminal domain; Region: HemN_C; pfam06969 391619000481 NnrU protein; Region: NnrU; pfam07298 391619000482 maleylacetoacetate isomerase; Region: maiA; TIGR01262 391619000483 GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042 391619000484 C-terminal domain interface [polypeptide binding]; other site 391619000485 GSH binding site (G-site) [chemical binding]; other site 391619000486 putative dimer interface [polypeptide binding]; other site 391619000487 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 391619000488 substrate binding pocket (H-site) [chemical binding]; other site 391619000489 N-terminal domain interface [polypeptide binding]; other site 391619000490 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 391619000491 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391619000492 Zn binding site [ion binding]; other site 391619000493 Protein of unknown function (DUF2783); Region: DUF2783; pfam10932 391619000494 FAD-dependent oxidoreductase; Provisional; Region: PRK08132 391619000495 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 391619000496 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 391619000497 fumarylacetoacetase; Region: PLN02856 391619000498 Domain of unknown function (DUF1969); Region: DUF1969; pfam09298 391619000499 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 391619000500 homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341 391619000501 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 391619000502 MarR family; Region: MarR_2; pfam12802 391619000503 MarR family; Region: MarR_2; cl17246 391619000504 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 391619000505 cyclase homology domain; Region: CHD; cd07302 391619000506 nucleotidyl binding site; other site 391619000507 metal binding site [ion binding]; metal-binding site 391619000508 dimer interface [polypeptide binding]; other site 391619000509 exosortase E/protease, VPEID-CTERM system; Region: exo_VPEID; TIGR04162 391619000510 exosortase/archaeosortase family protein; Region: exo_archaeo; TIGR04178 391619000511 CAAX protease self-immunity; Region: Abi; cl00558 391619000512 ATPase MipZ; Region: MipZ; pfam09140 391619000513 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 391619000514 P-loop; other site 391619000515 Magnesium ion binding site [ion binding]; other site 391619000516 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528 391619000517 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 391619000518 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 391619000519 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 391619000520 Phosphotransferase enzyme family; Region: APH; pfam01636 391619000521 active site 391619000522 ATP binding site [chemical binding]; other site 391619000523 RimM N-terminal domain; Region: RimM; pfam01782 391619000524 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828 391619000525 PRC-barrel domain; Region: PRC; pfam05239 391619000526 Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145 391619000527 putative FMN binding site [chemical binding]; other site 391619000528 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 391619000529 chorismate mutase; Provisional; Region: PRK09239 391619000530 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 391619000531 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 391619000532 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391619000533 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 391619000534 signal recognition particle protein; Provisional; Region: PRK10867 391619000535 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 391619000536 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 391619000537 P loop; other site 391619000538 GTP binding site [chemical binding]; other site 391619000539 Signal peptide binding domain; Region: SRP_SPB; pfam02978 391619000540 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 391619000541 elongation factor G; Reviewed; Region: PRK12740 391619000542 G1 box; other site 391619000543 GTP/Mg2+ binding site [chemical binding]; other site 391619000544 G2 box; other site 391619000545 Switch I region; other site 391619000546 G3 box; other site 391619000547 Switch II region; other site 391619000548 G4 box; other site 391619000549 G5 box; other site 391619000550 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 391619000551 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 391619000552 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 391619000553 putative deacylase active site [active] 391619000554 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391619000555 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391619000556 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391619000557 dimerization interface [polypeptide binding]; other site 391619000558 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 391619000559 EamA-like transporter family; Region: EamA; pfam00892 391619000560 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391619000561 dimerization interface [polypeptide binding]; other site 391619000562 putative DNA binding site [nucleotide binding]; other site 391619000563 putative Zn2+ binding site [ion binding]; other site 391619000564 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391619000565 EamA-like transporter family; Region: EamA; pfam00892 391619000566 EamA-like transporter family; Region: EamA; pfam00892 391619000567 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336 391619000568 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 391619000569 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 391619000570 F0F1 ATP synthase subunit C; Validated; Region: PRK07558 391619000571 F0F1 ATP synthase subunit B'; Provisional; Region: PRK13454 391619000572 F0F1 ATP synthase subunit B; Provisional; Region: PRK13455 391619000573 F0F1 ATP synthase subunit B; Provisional; Region: PRK14475 391619000574 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 391619000575 putative trimer interface [polypeptide binding]; other site 391619000576 putative CoA binding site [chemical binding]; other site 391619000577 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 391619000578 putative trimer interface [polypeptide binding]; other site 391619000579 putative active site [active] 391619000580 putative substrate binding site [chemical binding]; other site 391619000581 putative CoA binding site [chemical binding]; other site 391619000582 transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464 391619000583 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391619000584 DNA-binding site [nucleotide binding]; DNA binding site 391619000585 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 391619000586 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 391619000587 AAA domain; Region: AAA_23; pfam13476 391619000588 Walker A/P-loop; other site 391619000589 ATP binding site [chemical binding]; other site 391619000590 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 391619000591 Walker B; other site 391619000592 D-loop; other site 391619000593 H-loop/switch region; other site 391619000594 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 391619000595 Transglycosylase SLT domain; Region: SLT_2; pfam13406 391619000596 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 391619000597 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391619000598 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 391619000599 CobD/Cbib protein; Region: CobD_Cbib; pfam03186 391619000600 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391619000601 L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140 391619000602 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391619000603 catalytic residue [active] 391619000604 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 391619000605 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 391619000606 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 391619000607 putative dimer interface [polypeptide binding]; other site 391619000608 N-terminal domain interface [polypeptide binding]; other site 391619000609 putative substrate binding pocket (H-site) [chemical binding]; other site 391619000610 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 391619000611 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391619000612 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391619000613 homodimer interface [polypeptide binding]; other site 391619000614 catalytic residue [active] 391619000615 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 391619000616 active site 391619000617 catalytic residues [active] 391619000618 metal binding site [ion binding]; metal-binding site 391619000619 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 391619000620 active site 391619000621 catalytic residues [active] 391619000622 metal binding site [ion binding]; metal-binding site 391619000623 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 391619000624 active site 391619000625 catalytic residues [active] 391619000626 metal binding site [ion binding]; metal-binding site 391619000627 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 391619000628 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 391619000629 putative active site [active] 391619000630 substrate binding site [chemical binding]; other site 391619000631 putative cosubstrate binding site; other site 391619000632 catalytic site [active] 391619000633 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 391619000634 substrate binding site [chemical binding]; other site 391619000635 Predicted membrane protein [Function unknown]; Region: COG2860 391619000636 UPF0126 domain; Region: UPF0126; pfam03458 391619000637 UPF0126 domain; Region: UPF0126; pfam03458 391619000638 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 391619000639 RNA/DNA hybrid binding site [nucleotide binding]; other site 391619000640 active site 391619000641 Methyltransferase domain; Region: Methyltransf_23; pfam13489 391619000642 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391619000643 S-adenosylmethionine binding site [chemical binding]; other site 391619000644 Protein of unknown function (DUF3429); Region: DUF3429; pfam11911 391619000645 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 391619000646 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 391619000647 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 391619000648 Uncharacterized conserved protein [Function unknown]; Region: COG1432 391619000649 LabA_like proteins; Region: LabA; cd10911 391619000650 putative metal binding site [ion binding]; other site 391619000651 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 391619000652 catalytic center binding site [active] 391619000653 ATP binding site [chemical binding]; other site 391619000654 DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392 391619000655 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 391619000656 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 391619000657 Zn2+ binding site [ion binding]; other site 391619000658 Mg2+ binding site [ion binding]; other site 391619000659 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 391619000660 synthetase active site [active] 391619000661 NTP binding site [chemical binding]; other site 391619000662 metal binding site [ion binding]; metal-binding site 391619000663 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 391619000664 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 391619000665 Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835 391619000666 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 391619000667 active site 391619000668 hydrophilic channel; other site 391619000669 dimerization interface [polypeptide binding]; other site 391619000670 catalytic residues [active] 391619000671 active site lid [active] 391619000672 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 391619000673 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 391619000674 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 391619000675 Catalytic site [active] 391619000676 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 391619000677 ribonuclease III, bacterial; Region: RNaseIII; TIGR02191 391619000678 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 391619000679 dimerization interface [polypeptide binding]; other site 391619000680 active site 391619000681 metal binding site [ion binding]; metal-binding site 391619000682 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 391619000683 dsRNA binding site [nucleotide binding]; other site 391619000684 GTPase Era; Reviewed; Region: era; PRK00089 391619000685 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 391619000686 G1 box; other site 391619000687 GTP/Mg2+ binding site [chemical binding]; other site 391619000688 Switch I region; other site 391619000689 G2 box; other site 391619000690 Switch II region; other site 391619000691 G3 box; other site 391619000692 G4 box; other site 391619000693 G5 box; other site 391619000694 KH domain; Region: KH_2; pfam07650 391619000695 Protein of unknown function (DUF1491); Region: DUF1491; pfam07372 391619000696 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 391619000697 Recombination protein O N terminal; Region: RecO_N; pfam11967 391619000698 Recombination protein O C terminal; Region: RecO_C; pfam02565 391619000699 META domain; Region: META; pfam03724 391619000700 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391619000701 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391619000702 active site 391619000703 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 391619000704 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 391619000705 cation diffusion facilitator family transporter; Region: CDF; TIGR01297 391619000706 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 391619000707 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 391619000708 active site 391619000709 substrate-binding site [chemical binding]; other site 391619000710 metal-binding site [ion binding] 391619000711 ATP binding site [chemical binding]; other site 391619000712 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391619000713 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391619000714 active site 391619000715 phosphorylation site [posttranslational modification] 391619000716 intermolecular recognition site; other site 391619000717 dimerization interface [polypeptide binding]; other site 391619000718 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391619000719 DNA binding site [nucleotide binding] 391619000720 Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755 391619000721 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391619000722 HAMP domain; Region: HAMP; pfam00672 391619000723 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391619000724 dimer interface [polypeptide binding]; other site 391619000725 phosphorylation site [posttranslational modification] 391619000726 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391619000727 ATP binding site [chemical binding]; other site 391619000728 Mg2+ binding site [ion binding]; other site 391619000729 G-X-G motif; other site 391619000730 HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918 391619000731 Hpr binding site; other site 391619000732 active site 391619000733 homohexamer subunit interaction site [polypeptide binding]; other site 391619000734 glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416 391619000735 AAA domain; Region: AAA_18; pfam13238 391619000736 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025 391619000737 active pocket/dimerization site; other site 391619000738 active site 391619000739 phosphorylation site [posttranslational modification] 391619000740 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 391619000741 dimerization domain swap beta strand [polypeptide binding]; other site 391619000742 regulatory protein interface [polypeptide binding]; other site 391619000743 active site 391619000744 regulatory phosphorylation site [posttranslational modification]; other site 391619000745 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 391619000746 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 391619000747 putative acyl-acceptor binding pocket; other site 391619000748 3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530 391619000749 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 391619000750 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 391619000751 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 391619000752 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715 391619000753 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 391619000754 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 391619000755 Ligand binding site [chemical binding]; other site 391619000756 Electron transfer flavoprotein domain; Region: ETF; pfam01012 391619000757 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 391619000758 Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588 391619000759 short chain dehydrogenase; Provisional; Region: PRK05993 391619000760 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 391619000761 NADP binding site [chemical binding]; other site 391619000762 active site 391619000763 steroid binding site; other site 391619000764 Bacterial SH3 domain homologues; Region: SH3b; smart00287 391619000765 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 391619000766 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 391619000767 CAP-like domain; other site 391619000768 active site 391619000769 primary dimer interface [polypeptide binding]; other site 391619000770 elongation factor Tu; Reviewed; Region: PRK00049 391619000771 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 391619000772 G1 box; other site 391619000773 GEF interaction site [polypeptide binding]; other site 391619000774 GTP/Mg2+ binding site [chemical binding]; other site 391619000775 Switch I region; other site 391619000776 G2 box; other site 391619000777 G3 box; other site 391619000778 Switch II region; other site 391619000779 G4 box; other site 391619000780 G5 box; other site 391619000781 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 391619000782 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 391619000783 Antibiotic Binding Site [chemical binding]; other site 391619000784 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 391619000785 putative acyl-acceptor binding pocket; other site 391619000786 TPR repeat; Region: TPR_11; pfam13414 391619000787 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391619000788 binding surface 391619000789 TPR motif; other site 391619000790 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 391619000791 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391619000792 binding surface 391619000793 TPR motif; other site 391619000794 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 391619000795 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597 391619000796 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 391619000797 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 391619000798 putative homodimer interface [polypeptide binding]; other site 391619000799 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 391619000800 heterodimer interface [polypeptide binding]; other site 391619000801 homodimer interface [polypeptide binding]; other site 391619000802 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 391619000803 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 391619000804 23S rRNA interface [nucleotide binding]; other site 391619000805 L7/L12 interface [polypeptide binding]; other site 391619000806 putative thiostrepton binding site; other site 391619000807 L25 interface [polypeptide binding]; other site 391619000808 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 391619000809 mRNA/rRNA interface [nucleotide binding]; other site 391619000810 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 391619000811 23S rRNA interface [nucleotide binding]; other site 391619000812 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 391619000813 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 391619000814 core dimer interface [polypeptide binding]; other site 391619000815 peripheral dimer interface [polypeptide binding]; other site 391619000816 L10 interface [polypeptide binding]; other site 391619000817 L11 interface [polypeptide binding]; other site 391619000818 putative EF-Tu interaction site [polypeptide binding]; other site 391619000819 putative EF-G interaction site [polypeptide binding]; other site 391619000820 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 391619000821 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 391619000822 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 391619000823 RPB12 interaction site [polypeptide binding]; other site 391619000824 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 391619000825 RPB11 interaction site [polypeptide binding]; other site 391619000826 RPB12 interaction site [polypeptide binding]; other site 391619000827 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 391619000828 RPB3 interaction site [polypeptide binding]; other site 391619000829 RPB1 interaction site [polypeptide binding]; other site 391619000830 RPB11 interaction site [polypeptide binding]; other site 391619000831 RPB10 interaction site [polypeptide binding]; other site 391619000832 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 391619000833 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 391619000834 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 391619000835 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 391619000836 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 391619000837 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 391619000838 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 391619000839 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 391619000840 Ribosomal L27 protein; Region: Ribosomal_L27; cl00359 391619000841 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 391619000842 DNA binding site [nucleotide binding] 391619000843 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 391619000844 Putative rhamnosyl transferase; Region: Rhamno_transf; pfam11316 391619000845 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391619000846 Putative rhamnosyl transferase; Region: Rhamno_transf; pfam11316 391619000847 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 391619000848 S17 interaction site [polypeptide binding]; other site 391619000849 S8 interaction site; other site 391619000850 16S rRNA interaction site [nucleotide binding]; other site 391619000851 streptomycin interaction site [chemical binding]; other site 391619000852 23S rRNA interaction site [nucleotide binding]; other site 391619000853 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 391619000854 30S ribosomal protein S7; Validated; Region: PRK05302 391619000855 elongation factor G; Reviewed; Region: PRK00007 391619000856 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 391619000857 G1 box; other site 391619000858 putative GEF interaction site [polypeptide binding]; other site 391619000859 GTP/Mg2+ binding site [chemical binding]; other site 391619000860 Switch I region; other site 391619000861 G2 box; other site 391619000862 G3 box; other site 391619000863 Switch II region; other site 391619000864 G4 box; other site 391619000865 G5 box; other site 391619000866 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 391619000867 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 391619000868 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 391619000869 elongation factor Tu; Reviewed; Region: PRK00049 391619000870 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 391619000871 G1 box; other site 391619000872 GEF interaction site [polypeptide binding]; other site 391619000873 GTP/Mg2+ binding site [chemical binding]; other site 391619000874 Switch I region; other site 391619000875 G2 box; other site 391619000876 G3 box; other site 391619000877 Switch II region; other site 391619000878 G4 box; other site 391619000879 G5 box; other site 391619000880 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 391619000881 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 391619000882 Antibiotic Binding Site [chemical binding]; other site 391619000883 protoporphyrinogen oxidase; Region: PLN02576 391619000884 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 391619000885 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 391619000886 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 391619000887 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 391619000888 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 391619000889 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 391619000890 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 391619000891 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 391619000892 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 391619000893 putative translocon binding site; other site 391619000894 protein-rRNA interface [nucleotide binding]; other site 391619000895 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 391619000896 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 391619000897 G-X-X-G motif; other site 391619000898 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 391619000899 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 391619000900 23S rRNA interface [nucleotide binding]; other site 391619000901 5S rRNA interface [nucleotide binding]; other site 391619000902 putative antibiotic binding site [chemical binding]; other site 391619000903 L25 interface [polypeptide binding]; other site 391619000904 L27 interface [polypeptide binding]; other site 391619000905 Electron transfer DM13; Region: DM13; pfam10517 391619000906 conserved hypothetical protein; Region: TIGR02466 391619000907 pectinesterase; Region: PLN02314 391619000908 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 391619000909 23S rRNA interface [nucleotide binding]; other site 391619000910 putative translocon interaction site; other site 391619000911 signal recognition particle (SRP54) interaction site; other site 391619000912 L23 interface [polypeptide binding]; other site 391619000913 trigger factor interaction site; other site 391619000914 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 391619000915 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 391619000916 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 391619000917 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 391619000918 RNA binding site [nucleotide binding]; other site 391619000919 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 391619000920 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 391619000921 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 391619000922 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 391619000923 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 391619000924 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 391619000925 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 391619000926 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 391619000927 5S rRNA interface [nucleotide binding]; other site 391619000928 23S rRNA interface [nucleotide binding]; other site 391619000929 L5 interface [polypeptide binding]; other site 391619000930 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 391619000931 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 391619000932 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 391619000933 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 391619000934 23S rRNA binding site [nucleotide binding]; other site 391619000935 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 391619000936 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391619000937 DNA-binding site [nucleotide binding]; DNA binding site 391619000938 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391619000939 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391619000940 homodimer interface [polypeptide binding]; other site 391619000941 catalytic residue [active] 391619000942 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 391619000943 Ion channel; Region: Ion_trans_2; pfam07885 391619000944 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 391619000945 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 391619000946 SecY translocase; Region: SecY; pfam00344 391619000947 adenylate kinase; Reviewed; Region: adk; PRK00279 391619000948 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 391619000949 AMP-binding site [chemical binding]; other site 391619000950 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 391619000951 Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099 391619000952 30S ribosomal protein S13; Region: bact_S13; TIGR03631 391619000953 30S ribosomal protein S11; Validated; Region: PRK05309 391619000954 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 391619000955 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 391619000956 alphaNTD - beta interaction site [polypeptide binding]; other site 391619000957 alphaNTD homodimer interface [polypeptide binding]; other site 391619000958 alphaNTD - beta' interaction site [polypeptide binding]; other site 391619000959 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 391619000960 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 391619000961 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 391619000962 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 391619000963 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 391619000964 protein binding site [polypeptide binding]; other site 391619000965 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 391619000966 protein binding site [polypeptide binding]; other site 391619000967 recombination factor protein RarA; Reviewed; Region: PRK13342 391619000968 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391619000969 Walker A motif; other site 391619000970 ATP binding site [chemical binding]; other site 391619000971 Walker B motif; other site 391619000972 arginine finger; other site 391619000973 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 391619000974 CrcB-like protein; Region: CRCB; cl09114 391619000975 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 391619000976 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 391619000977 RNA binding surface [nucleotide binding]; other site 391619000978 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 391619000979 active site 391619000980 Eukaryotic phosphomannomutase; Region: PMM; cl17107 391619000981 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 391619000982 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391619000983 motif II; other site 391619000984 ATP12 chaperone protein; Region: ATP12; cl02228 391619000985 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 391619000986 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391619000987 substrate binding pocket [chemical binding]; other site 391619000988 membrane-bound complex binding site; other site 391619000989 hinge residues; other site 391619000990 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 391619000991 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 391619000992 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619000993 dimer interface [polypeptide binding]; other site 391619000994 ABC-ATPase subunit interface; other site 391619000995 putative PBP binding loops; other site 391619000996 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 391619000997 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619000998 dimer interface [polypeptide binding]; other site 391619000999 conserved gate region; other site 391619001000 putative PBP binding loops; other site 391619001001 ABC-ATPase subunit interface; other site 391619001002 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 391619001003 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 391619001004 Walker A/P-loop; other site 391619001005 ATP binding site [chemical binding]; other site 391619001006 Q-loop/lid; other site 391619001007 ABC transporter signature motif; other site 391619001008 Walker B; other site 391619001009 D-loop; other site 391619001010 H-loop/switch region; other site 391619001011 Protein of unknown function, DUF; Region: DUF411; cl01142 391619001012 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 391619001013 catalytic core [active] 391619001014 Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600 391619001015 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 391619001016 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 391619001017 feedback inhibition sensing region; other site 391619001018 homohexameric interface [polypeptide binding]; other site 391619001019 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 391619001020 nucleotide binding site [chemical binding]; other site 391619001021 N-acetyl-L-glutamate binding site [chemical binding]; other site 391619001022 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391619001023 classical (c) SDRs; Region: SDR_c; cd05233 391619001024 NAD(P) binding site [chemical binding]; other site 391619001025 active site 391619001026 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 391619001027 G1 box; other site 391619001028 GTP/Mg2+ binding site [chemical binding]; other site 391619001029 Switch I region; other site 391619001030 G2 box; other site 391619001031 G3 box; other site 391619001032 Switch II region; other site 391619001033 G4 box; other site 391619001034 G5 box; other site 391619001035 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 391619001036 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 391619001037 MOSC domain; Region: MOSC; pfam03473 391619001038 membrane protein insertase; Provisional; Region: PRK01318 391619001039 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 391619001040 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391619001041 metal binding site [ion binding]; metal-binding site 391619001042 active site 391619001043 I-site; other site 391619001044 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 391619001045 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 391619001046 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 391619001047 Ligand Binding Site [chemical binding]; other site 391619001048 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 391619001049 Haemolytic domain; Region: Haemolytic; pfam01809 391619001050 Ribonuclease P; Region: Ribonuclease_P; pfam00825 391619001051 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 391619001052 Uncharacterized conserved protein [Function unknown]; Region: COG0398 391619001053 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 391619001054 mercuric reductase; Validated; Region: PRK06370 391619001055 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391619001056 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391619001057 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 391619001058 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391619001059 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 391619001060 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391619001061 ATP binding site [chemical binding]; other site 391619001062 Mg2+ binding site [ion binding]; other site 391619001063 G-X-G motif; other site 391619001064 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 391619001065 extended (e) SDRs; Region: SDR_e; cd08946 391619001066 NAD(P) binding site [chemical binding]; other site 391619001067 active site 391619001068 substrate binding site [chemical binding]; other site 391619001069 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 391619001070 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 391619001071 active site 391619001072 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391619001073 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 391619001074 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391619001075 catalytic residue [active] 391619001076 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 391619001077 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 391619001078 NADP-binding site; other site 391619001079 homotetramer interface [polypeptide binding]; other site 391619001080 substrate binding site [chemical binding]; other site 391619001081 homodimer interface [polypeptide binding]; other site 391619001082 active site 391619001083 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 391619001084 Mechanosensitive ion channel; Region: MS_channel; pfam00924 391619001085 Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226 391619001086 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 391619001087 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391619001088 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 391619001089 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 391619001090 Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781 391619001091 DNA binding residues [nucleotide binding] 391619001092 putative dimer interface [polypeptide binding]; other site 391619001093 putative metal binding residues [ion binding]; other site 391619001094 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391619001095 putative substrate translocation pore; other site 391619001096 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391619001097 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 391619001098 active site 391619001099 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 391619001100 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 391619001101 HlyD family secretion protein; Region: HlyD_3; pfam13437 391619001102 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 391619001103 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391619001104 ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245 391619001105 Walker A/P-loop; other site 391619001106 ATP binding site [chemical binding]; other site 391619001107 Q-loop/lid; other site 391619001108 ABC transporter signature motif; other site 391619001109 Walker B; other site 391619001110 D-loop; other site 391619001111 H-loop/switch region; other site 391619001112 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 391619001113 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 391619001114 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 391619001115 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 391619001116 Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753 391619001117 PrkA family serine protein kinase; Provisional; Region: PRK15455 391619001118 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391619001119 Walker A motif; other site 391619001120 ATP binding site [chemical binding]; other site 391619001121 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 391619001122 hypothetical protein; Provisional; Region: PRK05325 391619001123 SpoVR family protein; Provisional; Region: PRK11767 391619001124 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 391619001125 Transcriptional regulators [Transcription]; Region: GntR; COG1802 391619001126 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391619001127 DNA-binding site [nucleotide binding]; DNA binding site 391619001128 FCD domain; Region: FCD; pfam07729 391619001129 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 391619001130 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 391619001131 substrate binding site [chemical binding]; other site 391619001132 catalytic Zn binding site [ion binding]; other site 391619001133 NAD binding site [chemical binding]; other site 391619001134 structural Zn binding site [ion binding]; other site 391619001135 dimer interface [polypeptide binding]; other site 391619001136 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 391619001137 metal-binding site [ion binding] 391619001138 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 391619001139 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 391619001140 metal-binding site [ion binding] 391619001141 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 391619001142 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391619001143 motif II; other site 391619001144 Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044 391619001145 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 391619001146 DNA binding residues [nucleotide binding] 391619001147 dimer interface [polypeptide binding]; other site 391619001148 copper binding site [ion binding]; other site 391619001149 Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853 391619001150 Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485 391619001151 Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463 391619001152 heterodimer interface [polypeptide binding]; other site 391619001153 active site 391619001154 Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208 391619001155 protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422 391619001156 active site 391619001157 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 391619001158 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 391619001159 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391619001160 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391619001161 dimerization interface [polypeptide binding]; other site 391619001162 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391619001163 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391619001164 TM-ABC transporter signature motif; other site 391619001165 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 391619001166 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391619001167 TM-ABC transporter signature motif; other site 391619001168 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391619001169 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 391619001170 Walker A/P-loop; other site 391619001171 ATP binding site [chemical binding]; other site 391619001172 Q-loop/lid; other site 391619001173 ABC transporter signature motif; other site 391619001174 Walker B; other site 391619001175 D-loop; other site 391619001176 H-loop/switch region; other site 391619001177 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391619001178 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 391619001179 Walker A/P-loop; other site 391619001180 ATP binding site [chemical binding]; other site 391619001181 Q-loop/lid; other site 391619001182 ABC transporter signature motif; other site 391619001183 Walker B; other site 391619001184 D-loop; other site 391619001185 H-loop/switch region; other site 391619001186 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 391619001187 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391619001188 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391619001189 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 391619001190 acyl-activating enzyme (AAE) consensus motif; other site 391619001191 acyl-activating enzyme (AAE) consensus motif; other site 391619001192 putative AMP binding site [chemical binding]; other site 391619001193 putative active site [active] 391619001194 putative CoA binding site [chemical binding]; other site 391619001195 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 391619001196 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 391619001197 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 391619001198 DNA-binding transcriptional activator of the SARP family [Signal transduction mechanisms]; Region: DnrI; COG3629 391619001199 Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862 391619001200 Predicted integral membrane protein [Function unknown]; Region: COG5616 391619001201 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 391619001202 binding surface 391619001203 TPR motif; other site 391619001204 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391619001205 TPR motif; other site 391619001206 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 391619001207 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 391619001208 NAD(P) binding site [chemical binding]; other site 391619001209 Hint domain; Region: Hint_2; pfam13403 391619001210 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391619001211 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391619001212 DNA binding site [nucleotide binding] 391619001213 domain linker motif; other site 391619001214 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 391619001215 putative dimerization interface [polypeptide binding]; other site 391619001216 putative ligand binding site [chemical binding]; other site 391619001217 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 391619001218 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 391619001219 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 391619001220 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619001221 dimer interface [polypeptide binding]; other site 391619001222 putative PBP binding loops; other site 391619001223 ABC-ATPase subunit interface; other site 391619001224 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391619001225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619001226 dimer interface [polypeptide binding]; other site 391619001227 conserved gate region; other site 391619001228 putative PBP binding loops; other site 391619001229 ABC-ATPase subunit interface; other site 391619001230 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 391619001231 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 391619001232 Walker A/P-loop; other site 391619001233 ATP binding site [chemical binding]; other site 391619001234 Q-loop/lid; other site 391619001235 ABC transporter signature motif; other site 391619001236 Walker B; other site 391619001237 D-loop; other site 391619001238 H-loop/switch region; other site 391619001239 TOBE domain; Region: TOBE_2; pfam08402 391619001240 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 391619001241 putative catalytic site [active] 391619001242 putative phosphate binding site [ion binding]; other site 391619001243 putative metal binding site [ion binding]; other site 391619001244 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169 391619001245 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 391619001246 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 391619001247 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 391619001248 DNA binding site [nucleotide binding] 391619001249 active site 391619001250 phosphoglyceromutase; Provisional; Region: PRK05434 391619001251 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 391619001252 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 391619001253 Peptidase family M23; Region: Peptidase_M23; pfam01551 391619001254 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 391619001255 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 391619001256 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 391619001257 protein binding site [polypeptide binding]; other site 391619001258 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 391619001259 Catalytic dyad [active] 391619001260 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 391619001261 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391619001262 4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243 391619001263 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 391619001264 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391619001265 NADH(P)-binding; Region: NAD_binding_10; pfam13460 391619001266 NAD(P) binding site [chemical binding]; other site 391619001267 active site 391619001268 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 391619001269 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 391619001270 Walker A/P-loop; other site 391619001271 ATP binding site [chemical binding]; other site 391619001272 Q-loop/lid; other site 391619001273 ABC transporter signature motif; other site 391619001274 Walker B; other site 391619001275 D-loop; other site 391619001276 H-loop/switch region; other site 391619001277 ABC-2 type transporter; Region: ABC2_membrane; cl17235 391619001278 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 391619001279 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 391619001280 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 391619001281 tandem repeat interface [polypeptide binding]; other site 391619001282 oligomer interface [polypeptide binding]; other site 391619001283 active site residues [active] 391619001284 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 391619001285 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 391619001286 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 391619001287 short chain dehydrogenase; Provisional; Region: PRK09134 391619001288 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391619001289 NAD(P) binding site [chemical binding]; other site 391619001290 active site 391619001291 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 391619001292 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 391619001293 GIY-YIG motif/motif A; other site 391619001294 active site 391619001295 catalytic site [active] 391619001296 putative DNA binding site [nucleotide binding]; other site 391619001297 metal binding site [ion binding]; metal-binding site 391619001298 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 391619001299 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 391619001300 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 391619001301 MoaE interaction surface [polypeptide binding]; other site 391619001302 MoeB interaction surface [polypeptide binding]; other site 391619001303 thiocarboxylated glycine; other site 391619001304 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 391619001305 MoaE homodimer interface [polypeptide binding]; other site 391619001306 MoaD interaction [polypeptide binding]; other site 391619001307 active site residues [active] 391619001308 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 391619001309 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 391619001310 ligand binding site [chemical binding]; other site 391619001311 4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878 391619001312 UbiA prenyltransferase family; Region: UbiA; pfam01040 391619001313 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 391619001314 RNA methyltransferase, RsmE family; Region: TIGR00046 391619001315 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 391619001316 Predicted ATPase involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: ArsA; COG0003 391619001317 glutamate--cysteine ligase; Region: PLN02611 391619001318 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 391619001319 dihydroorotase; Validated; Region: PRK09059 391619001320 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391619001321 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 391619001322 active site 391619001323 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 391619001324 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 391619001325 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 391619001326 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 391619001327 Fe-S cluster binding site [ion binding]; other site 391619001328 active site 391619001329 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 391619001330 MPT binding site; other site 391619001331 trimer interface [polypeptide binding]; other site 391619001332 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 391619001333 HlyD family secretion protein; Region: HlyD_3; pfam13437 391619001334 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 391619001335 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673 391619001336 nudix motif; other site 391619001337 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 391619001338 hypothetical protein; Validated; Region: PRK00228 391619001339 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 391619001340 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 391619001341 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391619001342 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391619001343 active site 391619001344 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 391619001345 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 391619001346 Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835 391619001347 Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437 391619001348 AzlC protein; Region: AzlC; pfam03591 391619001349 FdhD/NarQ family; Region: FdhD-NarQ; pfam02634 391619001350 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 391619001351 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 391619001352 GTP binding site; other site 391619001353 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 391619001354 Walker A motif; other site 391619001355 putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/unknown domain fusion protein; Provisional; Region: PRK14495 391619001356 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK14690 391619001357 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 391619001358 dimer interface [polypeptide binding]; other site 391619001359 putative functional site; other site 391619001360 putative MPT binding site; other site 391619001361 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 391619001362 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 391619001363 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 391619001364 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391619001365 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 391619001366 active site 391619001367 metal binding site [ion binding]; metal-binding site 391619001368 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 391619001369 redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950 391619001370 DNA binding residues [nucleotide binding] 391619001371 dimer interface [polypeptide binding]; other site 391619001372 [2Fe-2S] cluster binding site [ion binding]; other site 391619001373 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 391619001374 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391619001375 Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187 391619001376 TPR repeat; Region: TPR_11; pfam13414 391619001377 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391619001378 binding surface 391619001379 TPR motif; other site 391619001380 TPR repeat; Region: TPR_11; pfam13414 391619001381 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391619001382 binding surface 391619001383 TPR motif; other site 391619001384 TPR repeat; Region: TPR_11; pfam13414 391619001385 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 391619001386 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 391619001387 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 391619001388 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 391619001389 substrate binding pocket [chemical binding]; other site 391619001390 chain length determination region; other site 391619001391 substrate-Mg2+ binding site; other site 391619001392 catalytic residues [active] 391619001393 aspartate-rich region 1; other site 391619001394 active site lid residues [active] 391619001395 aspartate-rich region 2; other site 391619001396 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 391619001397 Methyltransferase domain; Region: Methyltransf_26; pfam13659 391619001398 Protein of unknown function (DUF465); Region: DUF465; cl01070 391619001399 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 391619001400 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391619001401 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 391619001402 dimerization interface [polypeptide binding]; other site 391619001403 substrate binding pocket [chemical binding]; other site 391619001404 acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829 391619001405 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 391619001406 NAD(P) binding site [chemical binding]; other site 391619001407 homotetramer interface [polypeptide binding]; other site 391619001408 homodimer interface [polypeptide binding]; other site 391619001409 active site 391619001410 putative acyltransferase; Provisional; Region: PRK05790 391619001411 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 391619001412 dimer interface [polypeptide binding]; other site 391619001413 active site 391619001414 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 391619001415 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 391619001416 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 391619001417 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 391619001418 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 391619001419 catalytic residues [active] 391619001420 argininosuccinate lyase; Provisional; Region: PRK00855 391619001421 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 391619001422 active sites [active] 391619001423 tetramer interface [polypeptide binding]; other site 391619001424 diaminopimelate decarboxylase; Region: lysA; TIGR01048 391619001425 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 391619001426 active site 391619001427 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 391619001428 substrate binding site [chemical binding]; other site 391619001429 catalytic residues [active] 391619001430 dimer interface [polypeptide binding]; other site 391619001431 Domain of unknown function (DUF4175); Region: DUF4175; pfam13779 391619001432 zinc-ribbon domain; Region: zinc_ribbon_4; pfam13717 391619001433 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 391619001434 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 391619001435 Walker A/P-loop; other site 391619001436 ATP binding site [chemical binding]; other site 391619001437 Q-loop/lid; other site 391619001438 ABC transporter signature motif; other site 391619001439 Walker B; other site 391619001440 D-loop; other site 391619001441 H-loop/switch region; other site 391619001442 Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177 391619001443 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 391619001444 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 391619001445 putative acyl-acceptor binding pocket; other site 391619001446 PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025 391619001447 EthD domain; Region: EthD; cl17553 391619001448 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 391619001449 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 391619001450 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391619001451 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 391619001452 MAPEG family; Region: MAPEG; pfam01124 391619001453 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 391619001454 E3 interaction surface; other site 391619001455 lipoyl attachment site [posttranslational modification]; other site 391619001456 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 391619001457 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 391619001458 E3 interaction surface; other site 391619001459 lipoyl attachment site [posttranslational modification]; other site 391619001460 e3 binding domain; Region: E3_binding; pfam02817 391619001461 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 391619001462 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 391619001463 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 391619001464 TPP-binding site [chemical binding]; other site 391619001465 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 391619001466 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 391619001467 CoA binding domain; Region: CoA_binding; pfam02629 391619001468 CoA-ligase; Region: Ligase_CoA; pfam00549 391619001469 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 391619001470 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 391619001471 CoA-ligase; Region: Ligase_CoA; pfam00549 391619001472 AAA domain; Region: AAA_28; pfam13521 391619001473 Predicted ATPase [General function prediction only]; Region: COG3911 391619001474 malate dehydrogenase; Reviewed; Region: PRK06223 391619001475 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 391619001476 NAD(P) binding site [chemical binding]; other site 391619001477 dimer interface [polypeptide binding]; other site 391619001478 tetramer (dimer of dimers) interface [polypeptide binding]; other site 391619001479 substrate binding site [chemical binding]; other site 391619001480 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 391619001481 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 391619001482 NnrU protein; Region: NnrU; pfam07298 391619001483 Uncharacterized conserved small protein [Function unknown]; Region: COG5515 391619001484 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 391619001485 putative active site [active] 391619001486 putative catalytic site [active] 391619001487 FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2 has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451 391619001488 putative active site [active] 391619001489 putative catalytic site [active] 391619001490 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 391619001491 catalytic core [active] 391619001492 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 391619001493 metal ion-dependent adhesion site (MIDAS); other site 391619001494 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 391619001495 Iron-sulfur protein interface; other site 391619001496 proximal quinone binding site [chemical binding]; other site 391619001497 SdhD (CybS) interface [polypeptide binding]; other site 391619001498 proximal heme binding site [chemical binding]; other site 391619001499 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495 391619001500 putative SdhC subunit interface [polypeptide binding]; other site 391619001501 putative proximal heme binding site [chemical binding]; other site 391619001502 putative Iron-sulfur protein interface [polypeptide binding]; other site 391619001503 putative proximal quinone binding site; other site 391619001504 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078 391619001505 L-aspartate oxidase; Provisional; Region: PRK06175 391619001506 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 391619001507 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 391619001508 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 391619001509 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 391619001510 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 391619001511 dimer interface [polypeptide binding]; other site 391619001512 active site 391619001513 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 391619001514 catalytic residues [active] 391619001515 substrate binding site [chemical binding]; other site 391619001516 Domain of unknown function (DUF1989); Region: DUF1989; cl01474 391619001517 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 391619001518 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 391619001519 H-NS histone family; Region: Histone_HNS; pfam00816 391619001520 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 391619001521 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 391619001522 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 391619001523 B12 binding site [chemical binding]; other site 391619001524 cobalt ligand [ion binding]; other site 391619001525 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 391619001526 Glycerol-3-phosphate O-acyltransferase [Lipid metabolism]; Region: PlsB; COG2937 391619001527 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 391619001528 putative acyl-acceptor binding pocket; other site 391619001529 crotonyl-CoA reductase; Region: crotonyl_coA_red; cd08246 391619001530 crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751 391619001531 putative NAD(P) binding site [chemical binding]; other site 391619001532 Autoinducer binding domain; Region: Autoind_bind; pfam03472 391619001533 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391619001534 DNA binding residues [nucleotide binding] 391619001535 dimerization interface [polypeptide binding]; other site 391619001536 Autoinducer synthetase; Region: Autoind_synth; cl17404 391619001537 AAA domain; Region: AAA_30; pfam13604 391619001538 Family description; Region: UvrD_C_2; pfam13538 391619001539 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 391619001540 classical (c) SDRs; Region: SDR_c; cd05233 391619001541 NAD(P) binding site [chemical binding]; other site 391619001542 active site 391619001543 Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608 391619001544 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 391619001545 hypothetical protein; Provisional; Region: PRK10621 391619001546 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 391619001547 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 391619001548 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391619001549 TM-ABC transporter signature motif; other site 391619001550 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 391619001551 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391619001552 TM-ABC transporter signature motif; other site 391619001553 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 391619001554 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391619001555 Walker A/P-loop; other site 391619001556 ATP binding site [chemical binding]; other site 391619001557 Q-loop/lid; other site 391619001558 ABC transporter signature motif; other site 391619001559 Walker B; other site 391619001560 D-loop; other site 391619001561 H-loop/switch region; other site 391619001562 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 391619001563 Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354 391619001564 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 391619001565 ligand binding site [chemical binding]; other site 391619001566 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391619001567 Coenzyme A binding pocket [chemical binding]; other site 391619001568 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 391619001569 Glycoprotease family; Region: Peptidase_M22; pfam00814 391619001570 Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712 391619001571 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 391619001572 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391619001573 Ligand Binding Site [chemical binding]; other site 391619001574 aminotransferase; Provisional; Region: PRK13356 391619001575 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 391619001576 homodimer interface [polypeptide binding]; other site 391619001577 substrate-cofactor binding pocket; other site 391619001578 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391619001579 catalytic residue [active] 391619001580 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346 391619001581 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 391619001582 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 391619001583 FAD binding pocket [chemical binding]; other site 391619001584 FAD binding motif [chemical binding]; other site 391619001585 phosphate binding motif [ion binding]; other site 391619001586 beta-alpha-beta structure motif; other site 391619001587 NAD(p) ribose binding residues [chemical binding]; other site 391619001588 NAD binding pocket [chemical binding]; other site 391619001589 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 391619001590 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391619001591 catalytic loop [active] 391619001592 iron binding site [ion binding]; other site 391619001593 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 391619001594 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 391619001595 Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138 391619001596 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 391619001597 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 391619001598 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 391619001599 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 391619001600 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 391619001601 dimer interface [polypeptide binding]; other site 391619001602 active site 391619001603 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 391619001604 Sulfatase; Region: Sulfatase; cl17466 391619001605 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391619001606 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 391619001607 substrate binding site [chemical binding]; other site 391619001608 oxyanion hole (OAH) forming residues; other site 391619001609 trimer interface [polypeptide binding]; other site 391619001610 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 391619001611 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 391619001612 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 391619001613 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 391619001614 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 391619001615 dimer interface [polypeptide binding]; other site 391619001616 active site 391619001617 pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204 391619001618 Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152 391619001619 FAD binding site [chemical binding]; other site 391619001620 substrate binding site [chemical binding]; other site 391619001621 catalytic base [active] 391619001622 pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203 391619001623 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 391619001624 active site 391619001625 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 391619001626 CoenzymeA binding site [chemical binding]; other site 391619001627 subunit interaction site [polypeptide binding]; other site 391619001628 PHB binding site; other site 391619001629 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 391619001630 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391619001631 acyl-activating enzyme (AAE) consensus motif; other site 391619001632 AMP binding site [chemical binding]; other site 391619001633 active site 391619001634 CoA binding site [chemical binding]; other site 391619001635 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 391619001636 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 391619001637 substrate binding site [chemical binding]; other site 391619001638 hexamer interface [polypeptide binding]; other site 391619001639 metal binding site [ion binding]; metal-binding site 391619001640 ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638 391619001641 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 391619001642 Walker A/P-loop; other site 391619001643 ATP binding site [chemical binding]; other site 391619001644 Q-loop/lid; other site 391619001645 ABC transporter signature motif; other site 391619001646 Walker B; other site 391619001647 D-loop; other site 391619001648 H-loop/switch region; other site 391619001649 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 391619001650 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 391619001651 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 391619001652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619001653 dimer interface [polypeptide binding]; other site 391619001654 conserved gate region; other site 391619001655 putative PBP binding loops; other site 391619001656 ABC-ATPase subunit interface; other site 391619001657 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 391619001658 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619001659 dimer interface [polypeptide binding]; other site 391619001660 conserved gate region; other site 391619001661 ABC-ATPase subunit interface; other site 391619001662 phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308 391619001663 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 391619001664 trimer interface [polypeptide binding]; other site 391619001665 active site 391619001666 substrate binding site [chemical binding]; other site 391619001667 CoA binding site [chemical binding]; other site 391619001668 phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325 391619001669 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391619001670 DNA-binding site [nucleotide binding]; DNA binding site 391619001671 UTRA domain; Region: UTRA; pfam07702 391619001672 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 391619001673 Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; pfam05845 391619001674 Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861 391619001675 Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007 391619001676 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 391619001677 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391619001678 Walker A/P-loop; other site 391619001679 ATP binding site [chemical binding]; other site 391619001680 Q-loop/lid; other site 391619001681 ABC transporter signature motif; other site 391619001682 Walker B; other site 391619001683 D-loop; other site 391619001684 H-loop/switch region; other site 391619001685 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391619001686 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 391619001687 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391619001688 Walker A/P-loop; other site 391619001689 ATP binding site [chemical binding]; other site 391619001690 Q-loop/lid; other site 391619001691 ABC transporter signature motif; other site 391619001692 Walker B; other site 391619001693 D-loop; other site 391619001694 H-loop/switch region; other site 391619001695 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 391619001696 active site 391619001697 putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223 391619001698 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 391619001699 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391619001700 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391619001701 active site 391619001702 S-adenosyl-L-methionine methyltransferase; Region: Methyltransf_17; pfam12692 391619001703 Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u4; cd10928 391619001704 NodB motif; other site 391619001705 putative active site [active] 391619001706 putative catalytic site [active] 391619001707 putative Zn binding site [ion binding]; other site 391619001708 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 391619001709 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 391619001710 Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369 391619001711 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 391619001712 catalytic core [active] 391619001713 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 391619001714 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 391619001715 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 391619001716 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 391619001717 putative ADP-binding pocket [chemical binding]; other site 391619001718 Predicted glycosyl transferase [General function prediction only]; Region: COG4671 391619001719 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 391619001720 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 391619001721 Mechanosensitive ion channel; Region: MS_channel; pfam00924 391619001722 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 391619001723 CoA-transferase family III; Region: CoA_transf_3; pfam02515 391619001724 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 391619001725 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 391619001726 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619001727 dimer interface [polypeptide binding]; other site 391619001728 conserved gate region; other site 391619001729 putative PBP binding loops; other site 391619001730 ABC-ATPase subunit interface; other site 391619001731 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391619001732 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619001733 dimer interface [polypeptide binding]; other site 391619001734 conserved gate region; other site 391619001735 putative PBP binding loops; other site 391619001736 ABC-ATPase subunit interface; other site 391619001737 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500 391619001738 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 391619001739 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 391619001740 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391619001741 Walker A/P-loop; other site 391619001742 ATP binding site [chemical binding]; other site 391619001743 Q-loop/lid; other site 391619001744 ABC transporter signature motif; other site 391619001745 Walker B; other site 391619001746 D-loop; other site 391619001747 H-loop/switch region; other site 391619001748 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391619001749 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391619001750 Walker A/P-loop; other site 391619001751 ATP binding site [chemical binding]; other site 391619001752 Q-loop/lid; other site 391619001753 ABC transporter signature motif; other site 391619001754 Walker B; other site 391619001755 D-loop; other site 391619001756 H-loop/switch region; other site 391619001757 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391619001758 S-adenosyl-L-methionine methyltransferase; Region: Methyltransf_17; pfam12692 391619001759 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 391619001760 GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051 391619001761 putative C-terminal domain interface [polypeptide binding]; other site 391619001762 putative GSH binding site (G-site) [chemical binding]; other site 391619001763 putative dimer interface [polypeptide binding]; other site 391619001764 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 391619001765 N-terminal domain interface [polypeptide binding]; other site 391619001766 dimer interface [polypeptide binding]; other site 391619001767 substrate binding pocket (H-site) [chemical binding]; other site 391619001768 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391619001769 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391619001770 2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13030 391619001771 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 391619001772 dimer interface [polypeptide binding]; other site 391619001773 PYR/PP interface [polypeptide binding]; other site 391619001774 TPP binding site [chemical binding]; other site 391619001775 substrate binding site [chemical binding]; other site 391619001776 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 391619001777 TPP-binding site [chemical binding]; other site 391619001778 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 391619001779 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391619001780 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391619001781 putative DNA binding site [nucleotide binding]; other site 391619001782 putative Zn2+ binding site [ion binding]; other site 391619001783 AsnC family; Region: AsnC_trans_reg; pfam01037 391619001784 Protein of unknown function (DUF3307); Region: DUF3307; pfam11750 391619001785 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 391619001786 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391619001787 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 391619001788 Walker A/P-loop; other site 391619001789 ATP binding site [chemical binding]; other site 391619001790 Q-loop/lid; other site 391619001791 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391619001792 Walker B; other site 391619001793 D-loop; other site 391619001794 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 391619001795 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 391619001796 ligand binding site [chemical binding]; other site 391619001797 flexible hinge region; other site 391619001798 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 391619001799 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 391619001800 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 391619001801 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 391619001802 active site pocket [active] 391619001803 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 391619001804 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 391619001805 NAD binding site [chemical binding]; other site 391619001806 catalytic Zn binding site [ion binding]; other site 391619001807 substrate binding site [chemical binding]; other site 391619001808 structural Zn binding site [ion binding]; other site 391619001809 Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013 391619001810 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 391619001811 tetramer interface [polypeptide binding]; other site 391619001812 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 391619001813 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 391619001814 putative catalytic site [active] 391619001815 putative metal binding site [ion binding]; other site 391619001816 putative phosphate binding site [ion binding]; other site 391619001817 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 391619001818 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 391619001819 tetramer interface [polypeptide binding]; other site 391619001820 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391619001821 catalytic residue [active] 391619001822 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 391619001823 2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428 391619001824 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391619001825 motif II; other site 391619001826 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 391619001827 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 391619001828 Nitronate monooxygenase; Region: NMO; pfam03060 391619001829 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 391619001830 FMN binding site [chemical binding]; other site 391619001831 substrate binding site [chemical binding]; other site 391619001832 putative catalytic residue [active] 391619001833 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 391619001834 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 391619001835 NAD binding site [chemical binding]; other site 391619001836 homotetramer interface [polypeptide binding]; other site 391619001837 homodimer interface [polypeptide binding]; other site 391619001838 substrate binding site [chemical binding]; other site 391619001839 active site 391619001840 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 391619001841 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 391619001842 dimer interface [polypeptide binding]; other site 391619001843 active site 391619001844 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 391619001845 active site 1 [active] 391619001846 dimer interface [polypeptide binding]; other site 391619001847 active site 2 [active] 391619001848 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 391619001849 metal binding site 2 [ion binding]; metal-binding site 391619001850 putative DNA binding helix; other site 391619001851 metal binding site 1 [ion binding]; metal-binding site 391619001852 dimer interface [polypeptide binding]; other site 391619001853 structural Zn2+ binding site [ion binding]; other site 391619001854 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391619001855 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391619001856 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391619001857 dimerization interface [polypeptide binding]; other site 391619001858 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 391619001859 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 391619001860 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 391619001861 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 391619001862 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391619001863 FeS/SAM binding site; other site 391619001864 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 391619001865 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 391619001866 ligand binding site [chemical binding]; other site 391619001867 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 391619001868 PhoH-like protein; Region: PhoH; pfam02562 391619001869 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 391619001870 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 391619001871 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 391619001872 Transporter associated domain; Region: CorC_HlyC; smart01091 391619001873 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 391619001874 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 391619001875 putative active site [active] 391619001876 catalytic triad [active] 391619001877 putative dimer interface [polypeptide binding]; other site 391619001878 S-adenosylmethionine synthetase; Validated; Region: PRK05250 391619001879 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 391619001880 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 391619001881 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 391619001882 Predicted periplasmic protein [Function unknown]; Region: COG3904 391619001883 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 391619001884 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 391619001885 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 391619001886 hinge; other site 391619001887 active site 391619001888 cytidylate kinase; Provisional; Region: cmk; PRK00023 391619001889 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 391619001890 CMP-binding site; other site 391619001891 The sites determining sugar specificity; other site 391619001892 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 391619001893 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 391619001894 RNA binding site [nucleotide binding]; other site 391619001895 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 391619001896 RNA binding site [nucleotide binding]; other site 391619001897 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 391619001898 RNA binding site [nucleotide binding]; other site 391619001899 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 391619001900 RNA binding site [nucleotide binding]; other site 391619001901 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 391619001902 RNA binding site [nucleotide binding]; other site 391619001903 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 391619001904 RNA binding site [nucleotide binding]; other site 391619001905 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 391619001906 IHF dimer interface [polypeptide binding]; other site 391619001907 IHF - DNA interface [nucleotide binding]; other site 391619001908 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 391619001909 active site 391619001910 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 391619001911 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 391619001912 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391619001913 catalytic residue [active] 391619001914 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 391619001915 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 391619001916 Beta-lactamase; Region: Beta-lactamase; pfam00144 391619001917 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 391619001918 putative active site [active] 391619001919 catalytic residue [active] 391619001920 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 391619001921 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 391619001922 5S rRNA interface [nucleotide binding]; other site 391619001923 CTC domain interface [polypeptide binding]; other site 391619001924 L16 interface [polypeptide binding]; other site 391619001925 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 391619001926 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 391619001927 active site 391619001928 substrate binding site [chemical binding]; other site 391619001929 FMN binding site [chemical binding]; other site 391619001930 putative catalytic residues [active] 391619001931 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 391619001932 substrate binding site [chemical binding]; other site 391619001933 active site 391619001934 catalytic residues [active] 391619001935 heterodimer interface [polypeptide binding]; other site 391619001936 Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411 391619001937 GTP-binding protein YchF; Reviewed; Region: PRK09601 391619001938 YchF GTPase; Region: YchF; cd01900 391619001939 G1 box; other site 391619001940 GTP/Mg2+ binding site [chemical binding]; other site 391619001941 Switch I region; other site 391619001942 G2 box; other site 391619001943 Switch II region; other site 391619001944 G3 box; other site 391619001945 G4 box; other site 391619001946 G5 box; other site 391619001947 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 391619001948 NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650 391619001949 active site 391619001950 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 391619001951 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391619001952 Walker A motif; other site 391619001953 ATP binding site [chemical binding]; other site 391619001954 Walker B motif; other site 391619001955 arginine finger; other site 391619001956 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391619001957 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 391619001958 DNA binding residues [nucleotide binding] 391619001959 Integrase core domain; Region: rve; pfam00665 391619001960 Predicted membrane protein (DUF2339); Region: DUF2339; pfam10101 391619001961 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 391619001962 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 391619001963 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 391619001964 [2Fe-2S] cluster binding site [ion binding]; other site 391619001965 C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884 391619001966 putative alpha subunit interface [polypeptide binding]; other site 391619001967 putative active site [active] 391619001968 putative substrate binding site [chemical binding]; other site 391619001969 Fe binding site [ion binding]; other site 391619001970 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 391619001971 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 391619001972 FAD binding pocket [chemical binding]; other site 391619001973 FAD binding motif [chemical binding]; other site 391619001974 phosphate binding motif [ion binding]; other site 391619001975 beta-alpha-beta structure motif; other site 391619001976 NAD binding pocket [chemical binding]; other site 391619001977 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391619001978 catalytic loop [active] 391619001979 iron binding site [ion binding]; other site 391619001980 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391619001981 short chain dehydrogenase; Provisional; Region: PRK07454 391619001982 classical (c) SDRs; Region: SDR_c; cd05233 391619001983 NAD(P) binding site [chemical binding]; other site 391619001984 active site 391619001985 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 391619001986 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 391619001987 inhibitor-cofactor binding pocket; inhibition site 391619001988 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391619001989 catalytic residue [active] 391619001990 WxcM-like, C-terminal; Region: FdtA; pfam05523 391619001991 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 391619001992 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 391619001993 active site 391619001994 Transcriptional regulators [Transcription]; Region: GntR; COG1802 391619001995 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391619001996 DNA-binding site [nucleotide binding]; DNA binding site 391619001997 FCD domain; Region: FCD; pfam07729 391619001998 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 391619001999 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 391619002000 inhibitor site; inhibition site 391619002001 active site 391619002002 dimer interface [polypeptide binding]; other site 391619002003 catalytic residue [active] 391619002004 Proline racemase; Region: Pro_racemase; pfam05544 391619002005 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 391619002006 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 391619002007 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391619002008 NAD(P) binding site [chemical binding]; other site 391619002009 catalytic residues [active] 391619002010 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 391619002011 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 391619002012 dimerization interface [polypeptide binding]; other site 391619002013 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 391619002014 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 391619002015 dimer interface [polypeptide binding]; other site 391619002016 putative CheW interface [polypeptide binding]; other site 391619002017 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 391619002018 Penicillinase repressor; Region: Pencillinase_R; pfam03965 391619002019 Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928 391619002020 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 391619002021 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391619002022 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619002023 dimer interface [polypeptide binding]; other site 391619002024 conserved gate region; other site 391619002025 ABC-ATPase subunit interface; other site 391619002026 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619002027 dimer interface [polypeptide binding]; other site 391619002028 conserved gate region; other site 391619002029 putative PBP binding loops; other site 391619002030 ABC-ATPase subunit interface; other site 391619002031 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391619002032 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 391619002033 Walker A/P-loop; other site 391619002034 ATP binding site [chemical binding]; other site 391619002035 Q-loop/lid; other site 391619002036 ABC transporter signature motif; other site 391619002037 Walker B; other site 391619002038 D-loop; other site 391619002039 H-loop/switch region; other site 391619002040 TOBE domain; Region: TOBE_2; pfam08402 391619002041 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391619002042 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 391619002043 Walker A/P-loop; other site 391619002044 ATP binding site [chemical binding]; other site 391619002045 Q-loop/lid; other site 391619002046 ABC transporter signature motif; other site 391619002047 Walker B; other site 391619002048 D-loop; other site 391619002049 H-loop/switch region; other site 391619002050 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391619002051 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391619002052 Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116 391619002053 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 391619002054 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 391619002055 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 391619002056 Bacterial sugar transferase; Region: Bac_transf; pfam02397 391619002057 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 391619002058 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 391619002059 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 391619002060 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 391619002061 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 391619002062 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 391619002063 putative ADP-binding pocket [chemical binding]; other site 391619002064 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 391619002065 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 391619002066 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 391619002067 active site 391619002068 Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977 391619002069 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 391619002070 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 391619002071 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 391619002072 active site 391619002073 substrate binding site [chemical binding]; other site 391619002074 cosubstrate binding site; other site 391619002075 catalytic site [active] 391619002076 C-terminal subdomain of the Formyltransferase-like domain found in OzmH-like proteins; Region: FMT_C_OzmH_like; cd08700 391619002077 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391619002078 acyl-activating enzyme (AAE) consensus motif; other site 391619002079 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 391619002080 natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020 391619002081 N5,N10-methylenetetrahydromethanopterin reductase (Mer) catalyzes the reduction of N5,N10-methylenetetrahydromethanopterin with reduced coenzyme F420 to N5-methyltetrahydromethanopterin and oxidized coenzyme F420; Region: Tetrahydromethanopterin_reductase; cd01097 391619002082 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 391619002083 AMP binding site [chemical binding]; other site 391619002084 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 391619002085 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 391619002086 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 391619002087 Probable Catalytic site; other site 391619002088 metal-binding site 391619002089 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 391619002090 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 391619002091 active site 391619002092 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 391619002093 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 391619002094 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 391619002095 putative NADP binding site [chemical binding]; other site 391619002096 This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822 391619002097 active site 391619002098 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 391619002099 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 391619002100 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 391619002101 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 391619002102 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 391619002103 active site 391619002104 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 391619002105 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 391619002106 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 391619002107 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 391619002108 Glucokinase; Region: Glucokinase; cl17310 391619002109 glucokinase, proteobacterial type; Region: glk; TIGR00749 391619002110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 391619002111 Family of unknown function (DUF490); Region: DUF490; pfam04357 391619002112 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 391619002113 Surface antigen; Region: Bac_surface_Ag; pfam01103 391619002114 Protein of unknown function (DUF989); Region: DUF989; pfam06181 391619002115 Predicted membrane protein [Function unknown]; Region: COG3748 391619002116 Cytochrome c; Region: Cytochrom_C; pfam00034 391619002117 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391619002118 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391619002119 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 391619002120 dimerization interface [polypeptide binding]; other site 391619002121 putative effector binding pocket; other site 391619002122 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 391619002123 active site 391619002124 homotetramer interface [polypeptide binding]; other site 391619002125 putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212 391619002126 Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977 391619002127 active site 391619002128 catalytic site [active] 391619002129 tetramer interface [polypeptide binding]; other site 391619002130 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195 391619002131 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 391619002132 Ureidoglycolate hydrolase; Region: Ureidogly_hydro; pfam04115 391619002133 xanthine permease; Region: pbuX; TIGR03173 391619002134 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 391619002135 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 391619002136 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 391619002137 hypothetical protein; Provisional; Region: PRK11171 391619002138 Cupin domain; Region: Cupin_2; cl17218 391619002139 Cupin domain; Region: Cupin_2; pfam07883 391619002140 beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431 391619002141 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 391619002142 Bacterial transcriptional regulator; Region: IclR; pfam01614 391619002143 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 391619002144 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 391619002145 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 391619002146 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 391619002147 lipoyl attachment site [posttranslational modification]; other site 391619002148 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391619002149 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391619002150 active site 391619002151 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 391619002152 Ligand Binding Site [chemical binding]; other site 391619002153 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 391619002154 active site 391619002155 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365 391619002156 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 391619002157 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 391619002158 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 391619002159 PAS domain; Region: PAS_9; pfam13426 391619002160 putative active site [active] 391619002161 heme pocket [chemical binding]; other site 391619002162 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 391619002163 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 391619002164 dimerization interface 3.5A [polypeptide binding]; other site 391619002165 active site 391619002166 YcjX-like family, DUF463; Region: DUF463; pfam04317 391619002167 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 391619002168 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391619002169 Coenzyme A binding pocket [chemical binding]; other site 391619002170 hypothetical protein; Provisional; Region: PRK05415 391619002171 Domain of unknown function (DUF697); Region: DUF697; pfam05128 391619002172 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 391619002173 heme-binding site [chemical binding]; other site 391619002174 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 391619002175 isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804 391619002176 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391619002177 active site 391619002178 HIGH motif; other site 391619002179 nucleotide binding site [chemical binding]; other site 391619002180 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 391619002181 active site 391619002182 KMSKS motif; other site 391619002183 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 391619002184 tRNA binding surface [nucleotide binding]; other site 391619002185 anticodon binding site; other site 391619002186 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 391619002187 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 391619002188 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 391619002189 DNA binding site [nucleotide binding] 391619002190 active site 391619002191 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 391619002192 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 391619002193 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 391619002194 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391619002195 active site 391619002196 DNA binding site [nucleotide binding] 391619002197 Int/Topo IB signature motif; other site 391619002198 Protein of unknown function, DUF484; Region: DUF484; cl17449 391619002199 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 391619002200 active site 391619002201 intersubunit interactions; other site 391619002202 catalytic residue [active] 391619002203 primosome assembly protein PriA; Validated; Region: PRK05580 391619002204 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391619002205 ATP binding site [chemical binding]; other site 391619002206 putative Mg++ binding site [ion binding]; other site 391619002207 Sulphur transport; Region: Sulf_transp; pfam04143 391619002208 MFS/sugar transport protein; Region: MFS_2; pfam13347 391619002209 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 391619002210 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391619002211 S-adenosylmethionine binding site [chemical binding]; other site 391619002212 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 391619002213 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 391619002214 active site 391619002215 putative DNA-binding cleft [nucleotide binding]; other site 391619002216 dimer interface [polypeptide binding]; other site 391619002217 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 391619002218 RuvA N terminal domain; Region: RuvA_N; pfam01330 391619002219 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 391619002220 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391619002221 Walker A motif; other site 391619002222 ATP binding site [chemical binding]; other site 391619002223 Walker B motif; other site 391619002224 arginine finger; other site 391619002225 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 391619002226 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 391619002227 active site 391619002228 TolQ protein; Region: tolQ; TIGR02796 391619002229 TolR protein; Region: tolR; TIGR02801 391619002230 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 391619002231 transport protein TonB; Provisional; Region: PRK10819 391619002232 translocation protein TolB; Provisional; Region: tolB; PRK05137 391619002233 TolB amino-terminal domain; Region: TolB_N; pfam04052 391619002234 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 391619002235 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 391619002236 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 391619002237 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 391619002238 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 391619002239 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 391619002240 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 391619002241 ligand binding site [chemical binding]; other site 391619002242 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 391619002243 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 391619002244 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 391619002245 FtsH Extracellular; Region: FtsH_ext; pfam06480 391619002246 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 391619002247 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391619002248 Walker A motif; other site 391619002249 ATP binding site [chemical binding]; other site 391619002250 Walker B motif; other site 391619002251 arginine finger; other site 391619002252 Peptidase family M41; Region: Peptidase_M41; pfam01434 391619002253 MOSC domain; Region: MOSC; pfam03473 391619002254 formate--tetrahydrofolate ligase; Provisional; Region: PRK13505 391619002255 Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477 391619002256 Potassium binding sites [ion binding]; other site 391619002257 Cesium cation binding sites [ion binding]; other site 391619002258 Chorismate mutase type II; Region: CM_2; smart00830 391619002259 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188 391619002260 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 391619002261 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 391619002262 homodimer interface [polypeptide binding]; other site 391619002263 NADP binding site [chemical binding]; other site 391619002264 substrate binding site [chemical binding]; other site 391619002265 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 391619002266 CoenzymeA binding site [chemical binding]; other site 391619002267 subunit interaction site [polypeptide binding]; other site 391619002268 PHB binding site; other site 391619002269 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 391619002270 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 391619002271 putative active site [active] 391619002272 putative metal binding site [ion binding]; other site 391619002273 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 391619002274 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391619002275 ATP binding site [chemical binding]; other site 391619002276 putative Mg++ binding site [ion binding]; other site 391619002277 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391619002278 nucleotide binding region [chemical binding]; other site 391619002279 ATP-binding site [chemical binding]; other site 391619002280 DEAD/H associated; Region: DEAD_assoc; pfam08494 391619002281 RNA helicase; Region: RNA_helicase; pfam00910 391619002282 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 391619002283 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 391619002284 Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010 391619002285 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 391619002286 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391619002287 TPR motif; other site 391619002288 binding surface 391619002289 TPR repeat; Region: TPR_11; pfam13414 391619002290 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 391619002291 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 391619002292 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 391619002293 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 391619002294 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 391619002295 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 391619002296 ATP binding site [chemical binding]; other site 391619002297 Walker A motif; other site 391619002298 hexamer interface [polypeptide binding]; other site 391619002299 Walker B motif; other site 391619002300 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 391619002301 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 391619002302 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 391619002303 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 391619002304 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 391619002305 ligand binding site [chemical binding]; other site 391619002306 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 391619002307 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 391619002308 BON domain; Region: BON; pfam04972 391619002309 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 391619002310 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 391619002311 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 391619002312 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 391619002313 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 391619002314 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391619002315 catalytic residue [active] 391619002316 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 391619002317 Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788 391619002318 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 391619002319 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 391619002320 active site 391619002321 interdomain interaction site; other site 391619002322 putative metal-binding site [ion binding]; other site 391619002323 nucleotide binding site [chemical binding]; other site 391619002324 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 391619002325 domain I; other site 391619002326 DNA binding groove [nucleotide binding] 391619002327 phosphate binding site [ion binding]; other site 391619002328 domain II; other site 391619002329 domain III; other site 391619002330 nucleotide binding site [chemical binding]; other site 391619002331 catalytic site [active] 391619002332 domain IV; other site 391619002333 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 391619002334 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 391619002335 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 391619002336 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 391619002337 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 391619002338 DNA protecting protein DprA; Region: dprA; TIGR00732 391619002339 protease TldD; Provisional; Region: tldD; PRK10735 391619002340 Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790 391619002341 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 391619002342 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 391619002343 protoheme IX farnesyltransferase; Provisional; Region: PRK04375 391619002344 UbiA prenyltransferase family; Region: UbiA; pfam01040 391619002345 cytochrome C oxidase assembly protein; Provisional; Region: PRK05089 391619002346 Cytochrome c oxidase subunit III. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665 391619002347 Subunit III/VIIa interface [polypeptide binding]; other site 391619002348 Phospholipid binding site [chemical binding]; other site 391619002349 Subunit I/III interface [polypeptide binding]; other site 391619002350 Subunit III/VIb interface [polypeptide binding]; other site 391619002351 Subunit III/VIa interface; other site 391619002352 Subunit III/Vb interface [polypeptide binding]; other site 391619002353 SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662 391619002354 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 391619002355 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 391619002356 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391619002357 catalytic residue [active] 391619002358 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 391619002359 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 391619002360 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 391619002361 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 391619002362 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 391619002363 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 391619002364 FAD binding domain; Region: FAD_binding_4; pfam01565 391619002365 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391619002366 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391619002367 putative substrate translocation pore; other site 391619002368 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 391619002369 Fasciclin domain; Region: Fasciclin; pfam02469 391619002370 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391619002371 active site 391619002372 5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931 391619002373 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 391619002374 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 391619002375 Sulfate transporter family; Region: Sulfate_transp; pfam00916 391619002376 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 391619002377 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 391619002378 Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349 391619002379 trimer interface [polypeptide binding]; other site 391619002380 active site 391619002381 substrate binding site [chemical binding]; other site 391619002382 CoA binding site [chemical binding]; other site 391619002383 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 391619002384 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391619002385 Coenzyme A binding pocket [chemical binding]; other site 391619002386 EcsC protein family; Region: EcsC; pfam12787 391619002387 Protein of unknown function (DUF1178); Region: DUF1178; pfam06676 391619002388 C factor cell-cell signaling protein; Provisional; Region: PRK09009 391619002389 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 391619002390 NADP binding site [chemical binding]; other site 391619002391 homodimer interface [polypeptide binding]; other site 391619002392 active site 391619002393 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 391619002394 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 391619002395 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 391619002396 glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348 391619002397 motif 1; other site 391619002398 dimer interface [polypeptide binding]; other site 391619002399 active site 391619002400 motif 2; other site 391619002401 motif 3; other site 391619002402 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 391619002403 Glycyl-tRNA synthetase beta subunit; Region: tRNA_synt_2f; pfam02092 391619002404 DALR anticodon binding domain; Region: DALR_1; pfam05746 391619002405 pyruvate phosphate dikinase; Provisional; Region: PRK09279 391619002406 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 391619002407 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 391619002408 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 391619002409 Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486 391619002410 Dihydroneopterin aldolase; Region: FolB; smart00905 391619002411 active site 391619002412 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 391619002413 dihydropteroate synthase; Region: DHPS; TIGR01496 391619002414 substrate binding pocket [chemical binding]; other site 391619002415 dimer interface [polypeptide binding]; other site 391619002416 inhibitor binding site; inhibition site 391619002417 phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315 391619002418 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 391619002419 active site 391619002420 substrate binding site [chemical binding]; other site 391619002421 metal binding site [ion binding]; metal-binding site 391619002422 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391619002423 EamA-like transporter family; Region: EamA; pfam00892 391619002424 EamA-like transporter family; Region: EamA; pfam00892 391619002425 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 391619002426 ketol-acid reductoisomerase; Provisional; Region: PRK05479 391619002427 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 391619002428 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 391619002429 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391619002430 AsnC family; Region: AsnC_trans_reg; pfam01037 391619002431 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391619002432 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391619002433 putative DNA binding site [nucleotide binding]; other site 391619002434 putative Zn2+ binding site [ion binding]; other site 391619002435 AsnC family; Region: AsnC_trans_reg; pfam01037 391619002436 Peptidase M50B-like; Region: Peptidase_M50B; pfam13398 391619002437 2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494 391619002438 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 391619002439 pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993 391619002440 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 391619002441 motif II; other site 391619002442 Transcriptional regulators [Transcription]; Region: FadR; COG2186 391619002443 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391619002444 DNA-binding site [nucleotide binding]; DNA binding site 391619002445 FCD domain; Region: FCD; pfam07729 391619002446 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 391619002447 CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427 391619002448 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 391619002449 DXD motif; other site 391619002450 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 391619002451 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 391619002452 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 391619002453 catalytic site [active] 391619002454 subunit interface [polypeptide binding]; other site 391619002455 Yqey-like protein; Region: YqeY; pfam09424 391619002456 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 391619002457 arogenate dehydrogenase; Region: PLN02256 391619002458 Integral membrane protein (DUF2244); Region: DUF2244; pfam10003 391619002459 Cytochrome C oxidase subunit I. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663 391619002460 Subunit I/III interface [polypeptide binding]; other site 391619002461 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 391619002462 D-pathway; other site 391619002463 Subunit I/VIIc interface [polypeptide binding]; other site 391619002464 Subunit I/IV interface [polypeptide binding]; other site 391619002465 Subunit I/II interface [polypeptide binding]; other site 391619002466 Low-spin heme (heme a) binding site [chemical binding]; other site 391619002467 Subunit I/VIIa interface [polypeptide binding]; other site 391619002468 Subunit I/VIa interface [polypeptide binding]; other site 391619002469 Dimer interface; other site 391619002470 Putative water exit pathway; other site 391619002471 Binuclear center (heme a3/CuB) [ion binding]; other site 391619002472 K-pathway; other site 391619002473 Subunit I/Vb interface [polypeptide binding]; other site 391619002474 Putative proton exit pathway; other site 391619002475 Subunit I/VIb interface; other site 391619002476 Subunit I/VIc interface [polypeptide binding]; other site 391619002477 Electron transfer pathway; other site 391619002478 Subunit I/VIIIb interface [polypeptide binding]; other site 391619002479 Subunit I/VIIb interface [polypeptide binding]; other site 391619002480 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 391619002481 HIT family signature motif; other site 391619002482 catalytic residue [active] 391619002483 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 391619002484 lipoate-protein ligase B; Provisional; Region: PRK14341 391619002485 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 391619002486 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391619002487 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 391619002488 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391619002489 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619002490 dimer interface [polypeptide binding]; other site 391619002491 conserved gate region; other site 391619002492 putative PBP binding loops; other site 391619002493 ABC-ATPase subunit interface; other site 391619002494 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 391619002495 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619002496 dimer interface [polypeptide binding]; other site 391619002497 conserved gate region; other site 391619002498 ABC-ATPase subunit interface; other site 391619002499 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 391619002500 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391619002501 Walker A/P-loop; other site 391619002502 ATP binding site [chemical binding]; other site 391619002503 Q-loop/lid; other site 391619002504 ABC transporter signature motif; other site 391619002505 Walker B; other site 391619002506 D-loop; other site 391619002507 H-loop/switch region; other site 391619002508 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391619002509 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 391619002510 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391619002511 Walker A/P-loop; other site 391619002512 ATP binding site [chemical binding]; other site 391619002513 Q-loop/lid; other site 391619002514 ABC transporter signature motif; other site 391619002515 Walker B; other site 391619002516 D-loop; other site 391619002517 H-loop/switch region; other site 391619002518 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 391619002519 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 391619002520 Beta-lactamase superfamily domain; Region: Lactamase_B_3; pfam13483 391619002521 HTH-like domain; Region: HTH_21; pfam13276 391619002522 Integrase core domain; Region: rve; pfam00665 391619002523 Transposase; Region: HTH_Tnp_1; cl17663 391619002524 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391619002525 TniQ; Region: TniQ; pfam06527 391619002526 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391619002527 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 391619002528 DNA binding residues [nucleotide binding] 391619002529 Integrase core domain; Region: rve; pfam00665 391619002530 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 391619002531 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391619002532 Walker A motif; other site 391619002533 ATP binding site [chemical binding]; other site 391619002534 Walker B motif; other site 391619002535 arginine finger; other site 391619002536 Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317 391619002537 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504 391619002538 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 391619002539 active site 391619002540 dimer interface [polypeptide binding]; other site 391619002541 effector binding site; other site 391619002542 TSCPD domain; Region: TSCPD; pfam12637 391619002543 Protein of unknown function (DUF1489); Region: DUF1489; pfam07370 391619002544 Protein of unknown function (DUF1244); Region: DUF1244; pfam06844 391619002545 pyruvate kinase; Provisional; Region: PRK06247 391619002546 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 391619002547 domain interfaces; other site 391619002548 active site 391619002549 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 391619002550 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 391619002551 23S rRNA binding site [nucleotide binding]; other site 391619002552 L21 binding site [polypeptide binding]; other site 391619002553 L13 binding site [polypeptide binding]; other site 391619002554 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 391619002555 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 391619002556 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 391619002557 dimer interface [polypeptide binding]; other site 391619002558 motif 1; other site 391619002559 active site 391619002560 motif 2; other site 391619002561 motif 3; other site 391619002562 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 391619002563 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 391619002564 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 391619002565 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 391619002566 putative tRNA-binding site [nucleotide binding]; other site 391619002567 B3/4 domain; Region: B3_4; pfam03483 391619002568 tRNA synthetase B5 domain; Region: B5; smart00874 391619002569 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 391619002570 dimer interface [polypeptide binding]; other site 391619002571 motif 1; other site 391619002572 motif 3; other site 391619002573 motif 2; other site 391619002574 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896 391619002575 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391619002576 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391619002577 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391619002578 dimerization interface [polypeptide binding]; other site 391619002579 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391619002580 S-adenosylmethionine binding site [chemical binding]; other site 391619002581 Protein of unknown function (DUF2872); Region: DUF2872; pfam11071 391619002582 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 391619002583 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391619002584 Mechanosensitive ion channel; Region: MS_channel; pfam00924 391619002585 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 391619002586 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 391619002587 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 391619002588 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 391619002589 Hint domain; Region: Hint_2; pfam13403 391619002590 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 391619002591 Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548 391619002592 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391619002593 Ligand Binding Site [chemical binding]; other site 391619002594 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391619002595 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 391619002596 putative DNA binding site [nucleotide binding]; other site 391619002597 putative Zn2+ binding site [ion binding]; other site 391619002598 AsnC family; Region: AsnC_trans_reg; pfam01037 391619002599 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 391619002600 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 391619002601 Cu(I) binding site [ion binding]; other site 391619002602 56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694 391619002603 Transcriptional regulator [Transcription]; Region: IclR; COG1414 391619002604 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 391619002605 Bacterial transcriptional regulator; Region: IclR; pfam01614 391619002606 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 391619002607 NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446 391619002608 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 391619002609 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391619002610 DNA binding site [nucleotide binding] 391619002611 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 391619002612 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 391619002613 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391619002614 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391619002615 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 391619002616 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 391619002617 intersubunit interface [polypeptide binding]; other site 391619002618 active site 391619002619 zinc binding site [ion binding]; other site 391619002620 Na+ binding site [ion binding]; other site 391619002621 KduI/IolB family; Region: KduI; pfam04962 391619002622 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 391619002623 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 391619002624 substrate binding site [chemical binding]; other site 391619002625 ATP binding site [chemical binding]; other site 391619002626 Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962 391619002627 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391619002628 dimer interface [polypeptide binding]; other site 391619002629 PYR/PP interface [polypeptide binding]; other site 391619002630 TPP binding site [chemical binding]; other site 391619002631 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 391619002632 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 391619002633 TPP-binding site [chemical binding]; other site 391619002634 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391619002635 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391619002636 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 391619002637 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 391619002638 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391619002639 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391619002640 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 391619002641 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391619002642 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391619002643 DNA binding site [nucleotide binding] 391619002644 domain linker motif; other site 391619002645 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 391619002646 putative dimerization interface [polypeptide binding]; other site 391619002647 putative ligand binding site [chemical binding]; other site 391619002648 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 391619002649 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312 391619002650 putative ligand binding site [chemical binding]; other site 391619002651 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391619002652 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391619002653 TM-ABC transporter signature motif; other site 391619002654 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 391619002655 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 391619002656 Walker A/P-loop; other site 391619002657 ATP binding site [chemical binding]; other site 391619002658 Q-loop/lid; other site 391619002659 ABC transporter signature motif; other site 391619002660 Walker B; other site 391619002661 D-loop; other site 391619002662 H-loop/switch region; other site 391619002663 Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874 391619002664 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 391619002665 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 391619002666 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 391619002667 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 391619002668 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 391619002669 active site 391619002670 intersubunit interface [polypeptide binding]; other site 391619002671 catalytic residue [active] 391619002672 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 391619002673 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 391619002674 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 391619002675 classical (c) SDRs; Region: SDR_c; cd05233 391619002676 NAD(P) binding site [chemical binding]; other site 391619002677 active site 391619002678 dihydroxy-acid dehydratase; Validated; Region: PRK06131 391619002679 Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345 391619002680 Melibiase; Region: Melibiase; pfam02065 391619002681 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391619002682 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619002683 dimer interface [polypeptide binding]; other site 391619002684 conserved gate region; other site 391619002685 putative PBP binding loops; other site 391619002686 ABC-ATPase subunit interface; other site 391619002687 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 391619002688 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619002689 dimer interface [polypeptide binding]; other site 391619002690 conserved gate region; other site 391619002691 putative PBP binding loops; other site 391619002692 ABC-ATPase subunit interface; other site 391619002693 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391619002694 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391619002695 Transcriptional regulator [Transcription]; Region: IclR; COG1414 391619002696 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 391619002697 Bacterial transcriptional regulator; Region: IclR; pfam01614 391619002698 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 391619002699 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 391619002700 Walker A/P-loop; other site 391619002701 ATP binding site [chemical binding]; other site 391619002702 Q-loop/lid; other site 391619002703 ABC transporter signature motif; other site 391619002704 Walker B; other site 391619002705 D-loop; other site 391619002706 H-loop/switch region; other site 391619002707 TOBE domain; Region: TOBE_2; pfam08402 391619002708 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 391619002709 NADH(P)-binding; Region: NAD_binding_10; pfam13460 391619002710 NAD(P) binding site [chemical binding]; other site 391619002711 putative active site [active] 391619002712 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 391619002713 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 391619002714 putative C-terminal domain interface [polypeptide binding]; other site 391619002715 putative GSH binding site (G-site) [chemical binding]; other site 391619002716 putative dimer interface [polypeptide binding]; other site 391619002717 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 391619002718 dimer interface [polypeptide binding]; other site 391619002719 N-terminal domain interface [polypeptide binding]; other site 391619002720 substrate binding pocket (H-site) [chemical binding]; other site 391619002721 hypothetical protein; Provisional; Region: PRK11019 391619002722 oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290 391619002723 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610 391619002724 active site 391619002725 Zn binding site [ion binding]; other site 391619002726 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 391619002727 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 391619002728 SCP-2 sterol transfer family; Region: SCP2; pfam02036 391619002729 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391619002730 binding surface 391619002731 TPR repeat; Region: TPR_11; pfam13414 391619002732 TPR motif; other site 391619002733 TPR repeat; Region: TPR_11; pfam13414 391619002734 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391619002735 nucleotide binding region [chemical binding]; other site 391619002736 ATP-binding site [chemical binding]; other site 391619002737 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 391619002738 RNA binding surface [nucleotide binding]; other site 391619002739 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 391619002740 4Fe-4S binding domain; Region: Fer4; pfam00037 391619002741 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 391619002742 Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329 391619002743 Ion channel; Region: Ion_trans_2; pfam07885 391619002744 cobalamin synthase; Reviewed; Region: cobS; PRK00235 391619002745 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 391619002746 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 391619002747 putative dimer interface [polypeptide binding]; other site 391619002748 active site pocket [active] 391619002749 putative cataytic base [active] 391619002750 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 391619002751 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 391619002752 TrkA-N domain; Region: TrkA_N; pfam02254 391619002753 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 391619002754 PAS domain; Region: PAS_9; pfam13426 391619002755 putative active site [active] 391619002756 heme pocket [chemical binding]; other site 391619002757 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391619002758 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 391619002759 AsnC family; Region: AsnC_trans_reg; pfam01037 391619002760 4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185 391619002761 N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342 391619002762 dimer interface [polypeptide binding]; other site 391619002763 C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250 391619002764 active site 391619002765 Fe binding site [ion binding]; other site 391619002766 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cl00322 391619002767 Uncharacterized conserved protein [Function unknown]; Region: COG2968 391619002768 Protein of unknown function (DUF541); Region: SIMPL; pfam04402 391619002769 O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873 391619002770 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 391619002771 homodimer interface [polypeptide binding]; other site 391619002772 substrate-cofactor binding pocket; other site 391619002773 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391619002774 catalytic residue [active] 391619002775 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391619002776 dimer interface [polypeptide binding]; other site 391619002777 phosphorylation site [posttranslational modification] 391619002778 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391619002779 ATP binding site [chemical binding]; other site 391619002780 Mg2+ binding site [ion binding]; other site 391619002781 G-X-G motif; other site 391619002782 Response regulator receiver domain; Region: Response_reg; pfam00072 391619002783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391619002784 active site 391619002785 phosphorylation site [posttranslational modification] 391619002786 intermolecular recognition site; other site 391619002787 dimerization interface [polypeptide binding]; other site 391619002788 Autoinducer synthetase; Region: Autoind_synth; cl17404 391619002789 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 391619002790 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 391619002791 active site 391619002792 substrate binding site [chemical binding]; other site 391619002793 FMN binding site [chemical binding]; other site 391619002794 putative catalytic residues [active] 391619002795 Thiamine pyrophosphate (TPP) family, ComE subfamily, TPP-binding module; composed of proteins similar to Methanococcus jannaschii sulfopyruvate decarboxylase beta subunit (ComE). M. jannaschii sulfopyruvate decarboxylase (ComDE) is a dodecamer of six...; Region: TPP_ComE; cd03372 391619002796 sulfopyruvate decarboxylase, beta subunit; Region: sulfopy_beta; TIGR03846 391619002797 TPP-binding site; other site 391619002798 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391619002799 PYR/PP interface [polypeptide binding]; other site 391619002800 dimer interface [polypeptide binding]; other site 391619002801 TPP binding site [chemical binding]; other site 391619002802 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391619002803 Ligand Binding Site [chemical binding]; other site 391619002804 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 391619002805 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 391619002806 NAD(P) binding site [chemical binding]; other site 391619002807 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 391619002808 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391619002809 NAD(P) binding site [chemical binding]; other site 391619002810 active site 391619002811 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 391619002812 histidinol dehydrogenase; Region: hisD; TIGR00069 391619002813 NAD binding site [chemical binding]; other site 391619002814 dimerization interface [polypeptide binding]; other site 391619002815 product binding site; other site 391619002816 substrate binding site [chemical binding]; other site 391619002817 zinc binding site [ion binding]; other site 391619002818 catalytic residues [active] 391619002819 DctM-like transporters; Region: DctM; pfam06808 391619002820 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 391619002821 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 391619002822 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 391619002823 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391619002824 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391619002825 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391619002826 DNA binding site [nucleotide binding] 391619002827 domain linker motif; other site 391619002828 This group includes the ligand-binding domain of putative DNA transcription repressors which are highly similar to that of the repressor specific for gluconate (GntR), a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_1; cd06273 391619002829 putative dimerization interface [polypeptide binding]; other site 391619002830 putative ligand binding site [chemical binding]; other site 391619002831 hypothetical protein; Provisional; Region: PRK07482 391619002832 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 391619002833 inhibitor-cofactor binding pocket; inhibition site 391619002834 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391619002835 catalytic residue [active] 391619002836 ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993 391619002837 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 391619002838 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 391619002839 active site 391619002840 acetylornithine deacetylase; Provisional; Region: PRK07522 391619002841 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 391619002842 metal binding site [ion binding]; metal-binding site 391619002843 putative dimer interface [polypeptide binding]; other site 391619002844 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 391619002845 beta-galactosidase; Region: BGL; TIGR03356 391619002846 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391619002847 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391619002848 DNA binding site [nucleotide binding] 391619002849 domain linker motif; other site 391619002850 Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271 391619002851 ligand binding site [chemical binding]; other site 391619002852 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391619002853 Z1 domain; Region: Z1; pfam10593 391619002854 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 391619002855 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619002856 dimer interface [polypeptide binding]; other site 391619002857 putative PBP binding loops; other site 391619002858 ABC-ATPase subunit interface; other site 391619002859 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391619002860 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619002861 dimer interface [polypeptide binding]; other site 391619002862 conserved gate region; other site 391619002863 putative PBP binding loops; other site 391619002864 ABC-ATPase subunit interface; other site 391619002865 Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330 391619002866 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 391619002867 active site 391619002868 catalytic site [active] 391619002869 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 391619002870 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 391619002871 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 391619002872 Walker A/P-loop; other site 391619002873 ATP binding site [chemical binding]; other site 391619002874 Q-loop/lid; other site 391619002875 ABC transporter signature motif; other site 391619002876 Walker B; other site 391619002877 D-loop; other site 391619002878 H-loop/switch region; other site 391619002879 TOBE domain; Region: TOBE; cl01440 391619002880 TOBE domain; Region: TOBE_2; pfam08402 391619002881 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 391619002882 Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521 391619002883 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391619002884 HAMP domain; Region: HAMP; pfam00672 391619002885 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391619002886 dimer interface [polypeptide binding]; other site 391619002887 phosphorylation site [posttranslational modification] 391619002888 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391619002889 ATP binding site [chemical binding]; other site 391619002890 Mg2+ binding site [ion binding]; other site 391619002891 G-X-G motif; other site 391619002892 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391619002893 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391619002894 active site 391619002895 phosphorylation site [posttranslational modification] 391619002896 intermolecular recognition site; other site 391619002897 dimerization interface [polypeptide binding]; other site 391619002898 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391619002899 DNA binding site [nucleotide binding] 391619002900 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 391619002901 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 391619002902 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 391619002903 Predicted permeases [General function prediction only]; Region: COG0679 391619002904 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 391619002905 putative hydrolase; Provisional; Region: PRK02113 391619002906 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 391619002907 active site 391619002908 DNA polymerase III subunit delta'; Validated; Region: PRK07471 391619002909 DNA polymerase III subunit delta'; Validated; Region: PRK08485 391619002910 thymidylate kinase; Validated; Region: tmk; PRK00698 391619002911 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 391619002912 TMP-binding site; other site 391619002913 ATP-binding site [chemical binding]; other site 391619002914 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 391619002915 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 391619002916 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 391619002917 Sporulation related domain; Region: SPOR; pfam05036 391619002918 Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643 391619002919 active site 391619002920 SAM binding site [chemical binding]; other site 391619002921 homodimer interface [polypeptide binding]; other site 391619002922 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 391619002923 active site 391619002924 SAM binding site [chemical binding]; other site 391619002925 homodimer interface [polypeptide binding]; other site 391619002926 cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077 391619002927 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 391619002928 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130 391619002929 Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641 391619002930 active site 391619002931 SAM binding site [chemical binding]; other site 391619002932 homodimer interface [polypeptide binding]; other site 391619002933 Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890 391619002934 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 391619002935 active site 391619002936 putative homodimer interface [polypeptide binding]; other site 391619002937 SAM binding site [chemical binding]; other site 391619002938 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 391619002939 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469 391619002940 Precorrin-6x reductase [Coenzyme metabolism]; Region: CobK; COG2099 391619002941 Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571 391619002942 Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646 391619002943 active site 391619002944 SAM binding site [chemical binding]; other site 391619002945 homodimer interface [polypeptide binding]; other site 391619002946 Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645 391619002947 active site 391619002948 SAM binding site [chemical binding]; other site 391619002949 homodimer interface [polypeptide binding]; other site 391619002950 precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285 391619002951 Precorrin-8X methylmutase; Region: CbiC; pfam02570 391619002952 precorrin-3B synthase; Region: CobG; TIGR02435 391619002953 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 391619002954 cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK12321 391619002955 CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150 391619002956 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 391619002957 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 391619002958 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 391619002959 Protein of unknown function (DUF1636); Region: DUF1636; pfam07845 391619002960 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 391619002961 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 391619002962 homodimer interface [polypeptide binding]; other site 391619002963 Walker A motif; other site 391619002964 ATP binding site [chemical binding]; other site 391619002965 hydroxycobalamin binding site [chemical binding]; other site 391619002966 Walker B motif; other site 391619002967 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 391619002968 active site 391619002969 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 391619002970 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391619002971 active site 391619002972 Predicted transcriptional regulators [Transcription]; Region: COG1733 391619002973 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 391619002974 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 391619002975 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 391619002976 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 391619002977 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 391619002978 Protein of unknown function (DUF1513); Region: DUF1513; pfam07433 391619002979 Imelysin; Region: Peptidase_M75; pfam09375 391619002980 Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488 391619002981 Protein of unknown function (DUF1111); Region: DUF1111; pfam06537 391619002982 Imelysin; Region: Peptidase_M75; cl09159 391619002983 Hemin uptake protein hemP; Region: hemP; pfam10636 391619002984 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391619002985 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391619002986 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391619002987 dimerization interface [polypeptide binding]; other site 391619002988 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 391619002989 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 391619002990 methionyl-tRNA synthetase; Reviewed; Region: PRK12268 391619002991 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 391619002992 active site 391619002993 HIGH motif; other site 391619002994 KMSKS motif; other site 391619002995 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 391619002996 tRNA binding surface [nucleotide binding]; other site 391619002997 anticodon binding site; other site 391619002998 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391619002999 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391619003000 putative substrate translocation pore; other site 391619003001 Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a...; Region: Polysulfide_ST; cd01447 391619003002 active site 391619003003 catalytic residue [active] 391619003004 Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a...; Region: Polysulfide_ST; cd01447 391619003005 active site 391619003006 catalytic residue [active] 391619003007 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 391619003008 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 391619003009 active site 391619003010 catalytic tetrad [active] 391619003011 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 391619003012 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 391619003013 conserved cys residue [active] 391619003014 Uncharacterized conserved protein [Function unknown]; Region: COG3246 391619003015 bifunctional 3-hydroxyacyl-CoA dehydrogenase/thioesterase; Validated; Region: PRK07531 391619003016 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 391619003017 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 391619003018 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 391619003019 active site 391619003020 short chain dehydrogenase; Provisional; Region: PRK12829 391619003021 classical (c) SDRs; Region: SDR_c; cd05233 391619003022 NAD(P) binding site [chemical binding]; other site 391619003023 active site 391619003024 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391619003025 non-specific DNA binding site [nucleotide binding]; other site 391619003026 salt bridge; other site 391619003027 sequence-specific DNA binding site [nucleotide binding]; other site 391619003028 Predicted membrane protein (DUF2061); Region: DUF2061; cl01257 391619003029 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 391619003030 Fatty acid desaturase; Region: FA_desaturase; pfam00487 391619003031 putative di-iron ligands [ion binding]; other site 391619003032 NUDIX domain; Region: NUDIX; pfam00293 391619003033 nudix motif; other site 391619003034 nudix motif; other site 391619003035 Protein of unknown function (DUF983); Region: DUF983; cl02211 391619003036 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 391619003037 Ca2+ binding site [ion binding]; other site 391619003038 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 391619003039 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391619003040 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391619003041 DNA binding residues [nucleotide binding] 391619003042 Heavy-metal resistance; Region: Metal_resist; pfam13801 391619003043 response regulator PleD; Reviewed; Region: pleD; PRK09581 391619003044 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391619003045 active site 391619003046 phosphorylation site [posttranslational modification] 391619003047 intermolecular recognition site; other site 391619003048 dimerization interface [polypeptide binding]; other site 391619003049 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391619003050 metal binding site [ion binding]; metal-binding site 391619003051 active site 391619003052 I-site; other site 391619003053 Protein of unknown function (DUF3572); Region: DUF3572; pfam12096 391619003054 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 391619003055 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391619003056 motif II; other site 391619003057 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 391619003058 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 391619003059 Heme NO binding; Region: HNOB; pfam07700 391619003060 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 391619003061 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391619003062 metal binding site [ion binding]; metal-binding site 391619003063 active site 391619003064 I-site; other site 391619003065 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 391619003066 DHH family; Region: DHH; pfam01368 391619003067 DHHA1 domain; Region: DHHA1; pfam02272 391619003068 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 391619003069 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 391619003070 putative active site [active] 391619003071 homoserine dehydrogenase; Provisional; Region: PRK06349 391619003072 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 391619003073 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 391619003074 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 391619003075 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391619003076 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391619003077 Pirin-related protein [General function prediction only]; Region: COG1741 391619003078 Pirin; Region: Pirin; pfam02678 391619003079 Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726 391619003080 TadE-like protein; Region: TadE; pfam07811 391619003081 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 391619003082 TadE-like protein; Region: TadE; pfam07811 391619003083 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 391619003084 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 391619003085 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 391619003086 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 391619003087 NAD(P) binding site [chemical binding]; other site 391619003088 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 391619003089 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391619003090 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 391619003091 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 391619003092 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 391619003093 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391619003094 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391619003095 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 391619003096 DNA primase, catalytic core; Region: dnaG; TIGR01391 391619003097 CHC2 zinc finger; Region: zf-CHC2; cl17510 391619003098 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 391619003099 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 391619003100 active site 391619003101 metal binding site [ion binding]; metal-binding site 391619003102 interdomain interaction site; other site 391619003103 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 391619003104 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 391619003105 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 391619003106 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 391619003107 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 391619003108 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391619003109 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 391619003110 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391619003111 DNA binding residues [nucleotide binding] 391619003112 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391619003113 NAD(P) binding site [chemical binding]; other site 391619003114 active site 391619003115 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 391619003116 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 391619003117 ATP cone domain; Region: ATP-cone; pfam03477 391619003118 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 391619003119 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 391619003120 catalytic motif [active] 391619003121 Zn binding site [ion binding]; other site 391619003122 RibD C-terminal domain; Region: RibD_C; cl17279 391619003123 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 391619003124 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 391619003125 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 391619003126 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 391619003127 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 391619003128 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 391619003129 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 391619003130 Lumazine binding domain; Region: Lum_binding; pfam00677 391619003131 Lumazine binding domain; Region: Lum_binding; pfam00677 391619003132 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019 391619003133 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 391619003134 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 391619003135 dimerization interface [polypeptide binding]; other site 391619003136 active site 391619003137 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 391619003138 homopentamer interface [polypeptide binding]; other site 391619003139 active site 391619003140 transcription antitermination factor NusB; Region: nusB; TIGR01951 391619003141 putative RNA binding site [nucleotide binding]; other site 391619003142 Protein of unknown function (DUF1052); Region: DUF1052; cl02197 391619003143 pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005 391619003144 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 391619003145 RNA binding surface [nucleotide binding]; other site 391619003146 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 391619003147 active site 391619003148 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 391619003149 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 391619003150 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391619003151 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391619003152 DNA binding residues [nucleotide binding] 391619003153 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 391619003154 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 391619003155 dimerization interface [polypeptide binding]; other site 391619003156 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 391619003157 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 391619003158 dimer interface [polypeptide binding]; other site 391619003159 putative CheW interface [polypeptide binding]; other site 391619003160 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 391619003161 substrate binding site [chemical binding]; other site 391619003162 ATP binding site [chemical binding]; other site 391619003163 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 391619003164 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 391619003165 ATP binding site [chemical binding]; other site 391619003166 substrate interface [chemical binding]; other site 391619003167 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 391619003168 active site residue [active] 391619003169 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 391619003170 thiamine phosphate binding site [chemical binding]; other site 391619003171 active site 391619003172 pyrophosphate binding site [ion binding]; other site 391619003173 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 391619003174 ThiS interaction site; other site 391619003175 putative active site [active] 391619003176 tetramer interface [polypeptide binding]; other site 391619003177 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 391619003178 thiS-thiF/thiG interaction site; other site 391619003179 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 391619003180 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 391619003181 ThiC-associated domain; Region: ThiC-associated; pfam13667 391619003182 ThiC family; Region: ThiC; pfam01964 391619003183 biotin synthase; Region: bioB; TIGR00433 391619003184 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391619003185 FeS/SAM binding site; other site 391619003186 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 391619003187 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 391619003188 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391619003189 catalytic residue [active] 391619003190 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 391619003191 AAA domain; Region: AAA_26; pfam13500 391619003192 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 391619003193 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 391619003194 inhibitor-cofactor binding pocket; inhibition site 391619003195 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391619003196 catalytic residue [active] 391619003197 Protein of unknown function (DUF452); Region: DUF452; cl01062 391619003198 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 391619003199 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391619003200 S-adenosylmethionine binding site [chemical binding]; other site 391619003201 Protein of unknown function (DUF2478); Region: DUF2478; pfam10649 391619003202 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 391619003203 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 391619003204 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 391619003205 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 391619003206 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 391619003207 metal binding site [ion binding]; metal-binding site 391619003208 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 391619003209 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 391619003210 substrate binding site [chemical binding]; other site 391619003211 glutamase interaction surface [polypeptide binding]; other site 391619003212 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 391619003213 Domain of unknown function DUF302; Region: DUF302; pfam03625 391619003214 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 391619003215 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 391619003216 catalytic residues [active] 391619003217 Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917 391619003218 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 391619003219 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 391619003220 putative catalytic residues [active] 391619003221 Cupin; Region: Cupin_6; pfam12852 391619003222 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391619003223 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 391619003224 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391619003225 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146 391619003226 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 391619003227 putative active site [active] 391619003228 oxyanion strand; other site 391619003229 catalytic triad [active] 391619003230 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 391619003231 putative active site pocket [active] 391619003232 4-fold oligomerization interface [polypeptide binding]; other site 391619003233 metal binding residues [ion binding]; metal-binding site 391619003234 3-fold/trimer interface [polypeptide binding]; other site 391619003235 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391619003236 AsnC family; Region: AsnC_trans_reg; pfam01037 391619003237 aminotransferase; Provisional; Region: PRK06105 391619003238 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 391619003239 inhibitor-cofactor binding pocket; inhibition site 391619003240 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391619003241 catalytic residue [active] 391619003242 Restriction endonuclease NaeI; Region: NaeI; pfam09126 391619003243 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 391619003244 DNA-methyltransferase (dcm); Region: dcm; TIGR00675 391619003245 cofactor binding site; other site 391619003246 DNA binding site [nucleotide binding] 391619003247 substrate interaction site [chemical binding]; other site 391619003248 pyruvate carboxylase; Reviewed; Region: PRK12999 391619003249 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391619003250 ATP-grasp domain; Region: ATP-grasp_4; cl17255 391619003251 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 391619003252 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 391619003253 active site 391619003254 catalytic residues [active] 391619003255 metal binding site [ion binding]; metal-binding site 391619003256 homodimer binding site [polypeptide binding]; other site 391619003257 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 391619003258 carboxyltransferase (CT) interaction site; other site 391619003259 biotinylation site [posttranslational modification]; other site 391619003260 Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304 391619003261 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 391619003262 phosphate binding site [ion binding]; other site 391619003263 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 391619003264 GAF domain; Region: GAF_3; pfam13492 391619003265 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 391619003266 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391619003267 metal binding site [ion binding]; metal-binding site 391619003268 active site 391619003269 I-site; other site 391619003270 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 391619003271 Part of AAA domain; Region: AAA_19; pfam13245 391619003272 Family description; Region: UvrD_C_2; pfam13538 391619003273 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 391619003274 Domain of unknown function DUF59; Region: DUF59; pfam01883 391619003275 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 391619003276 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 391619003277 Walker A motif; other site 391619003278 cell division protein MraZ; Reviewed; Region: PRK00326 391619003279 MraZ protein; Region: MraZ; pfam02381 391619003280 MraZ protein; Region: MraZ; pfam02381 391619003281 MraW methylase family; Region: Methyltransf_5; cl17771 391619003282 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 391619003283 Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462 391619003284 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 391619003285 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 391619003286 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 391619003287 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 391619003288 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 391619003289 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 391619003290 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 391619003291 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 391619003292 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 391619003293 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 391619003294 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 391619003295 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 391619003296 Mg++ binding site [ion binding]; other site 391619003297 putative catalytic motif [active] 391619003298 putative substrate binding site [chemical binding]; other site 391619003299 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 391619003300 glutaminase; Provisional; Region: PRK00971 391619003301 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390 391619003302 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 391619003303 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 391619003304 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 391619003305 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 391619003306 MarR family; Region: MarR_2; pfam12802 391619003307 Uncharacterized conserved protein [Function unknown]; Region: COG1359 391619003308 HI0933-like protein; Region: HI0933_like; pfam03486 391619003309 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391619003310 cell division protein FtsW; Region: ftsW; TIGR02614 391619003311 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 391619003312 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 391619003313 active site 391619003314 homodimer interface [polypeptide binding]; other site 391619003315 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 391619003316 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 391619003317 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 391619003318 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 391619003319 Protein of unknown function (DUF2484); Region: DUF2484; pfam10658 391619003320 Protein of unknown function (DUF2484); Region: DUF2484; pfam10658 391619003321 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 391619003322 FAD binding domain; Region: FAD_binding_4; pfam01565 391619003323 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 391619003324 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 391619003325 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 391619003326 ATP-grasp domain; Region: ATP-grasp_4; cl17255 391619003327 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 391619003328 Cell division protein FtsQ; Region: FtsQ; pfam03799 391619003329 Cell division protein FtsA; Region: FtsA; smart00842 391619003330 Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849 391619003331 Cell division protein FtsA; Region: FtsA; pfam14450 391619003332 cell division protein FtsZ; Validated; Region: PRK09330 391619003333 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 391619003334 nucleotide binding site [chemical binding]; other site 391619003335 SulA interaction site; other site 391619003336 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 391619003337 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 391619003338 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 391619003339 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 391619003340 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 391619003341 Walker A/P-loop; other site 391619003342 ATP binding site [chemical binding]; other site 391619003343 Q-loop/lid; other site 391619003344 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 391619003345 ABC transporter signature motif; other site 391619003346 Walker B; other site 391619003347 D-loop; other site 391619003348 H-loop/switch region; other site 391619003349 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 391619003350 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 391619003351 Cl- selectivity filter; other site 391619003352 Cl- binding residues [ion binding]; other site 391619003353 pore gating glutamate residue; other site 391619003354 dimer interface [polypeptide binding]; other site 391619003355 Domain of unknown function (DUF427); Region: DUF427; pfam04248 391619003356 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 391619003357 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 391619003358 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 391619003359 active site 391619003360 Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213 391619003361 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 391619003362 metal ion-dependent adhesion site (MIDAS); other site 391619003363 Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556 391619003364 cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650 391619003365 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 391619003366 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 391619003367 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 391619003368 ATP binding site [chemical binding]; other site 391619003369 Mg++ binding site [ion binding]; other site 391619003370 motif III; other site 391619003371 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391619003372 nucleotide binding region [chemical binding]; other site 391619003373 ATP-binding site [chemical binding]; other site 391619003374 RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252 391619003375 RNA binding site [nucleotide binding]; other site 391619003376 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 391619003377 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 391619003378 HSP70 interaction site [polypeptide binding]; other site 391619003379 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 391619003380 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 391619003381 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 391619003382 GatB domain; Region: GatB_Yqey; smart00845 391619003383 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 391619003384 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 391619003385 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 391619003386 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 391619003387 RNA binding site [nucleotide binding]; other site 391619003388 aminopeptidase N; Provisional; Region: pepN; PRK14015 391619003389 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 391619003390 active site 391619003391 Zn binding site [ion binding]; other site 391619003392 malate synthase G; Provisional; Region: PRK02999 391619003393 active site 391619003394 Domain of unknown function (DUF336); Region: DUF336; cl01249 391619003395 Peptidase C26; Region: Peptidase_C26; pfam07722 391619003396 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 391619003397 catalytic triad [active] 391619003398 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 391619003399 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 391619003400 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 391619003401 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 391619003402 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 391619003403 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 391619003404 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 391619003405 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391619003406 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391619003407 tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036 391619003408 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391619003409 kynureninase; Region: kynureninase; TIGR01814 391619003410 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391619003411 catalytic residue [active] 391619003412 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 391619003413 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391619003414 classical (c) SDRs; Region: SDR_c; cd05233 391619003415 NAD(P) binding site [chemical binding]; other site 391619003416 active site 391619003417 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 391619003418 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 391619003419 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 391619003420 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 391619003421 ligand binding site [chemical binding]; other site 391619003422 homodimer interface [polypeptide binding]; other site 391619003423 NAD(P) binding site [chemical binding]; other site 391619003424 trimer interface B [polypeptide binding]; other site 391619003425 trimer interface A [polypeptide binding]; other site 391619003426 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 391619003427 NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566 391619003428 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 391619003429 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391619003430 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 391619003431 active site 391619003432 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 391619003433 Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109 391619003434 DNA binding residues [nucleotide binding] 391619003435 putative dimer interface [polypeptide binding]; other site 391619003436 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 391619003437 Protein of unknown function (DUF3422); Region: DUF3422; pfam11902 391619003438 Sulphur transport; Region: Sulf_transp; pfam04143 391619003439 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 391619003440 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 391619003441 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619003442 dimer interface [polypeptide binding]; other site 391619003443 conserved gate region; other site 391619003444 putative PBP binding loops; other site 391619003445 ABC-ATPase subunit interface; other site 391619003446 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391619003447 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619003448 dimer interface [polypeptide binding]; other site 391619003449 conserved gate region; other site 391619003450 putative PBP binding loops; other site 391619003451 ABC-ATPase subunit interface; other site 391619003452 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391619003453 The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513 391619003454 peptide binding site [polypeptide binding]; other site 391619003455 dimer interface [polypeptide binding]; other site 391619003456 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391619003457 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 391619003458 Walker A/P-loop; other site 391619003459 ATP binding site [chemical binding]; other site 391619003460 Q-loop/lid; other site 391619003461 ABC transporter signature motif; other site 391619003462 Walker B; other site 391619003463 D-loop; other site 391619003464 H-loop/switch region; other site 391619003465 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 391619003466 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391619003467 Walker A/P-loop; other site 391619003468 ATP binding site [chemical binding]; other site 391619003469 Q-loop/lid; other site 391619003470 ABC transporter signature motif; other site 391619003471 Walker B; other site 391619003472 D-loop; other site 391619003473 H-loop/switch region; other site 391619003474 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 391619003475 acetylornithine deacetylase; Provisional; Region: PRK07522 391619003476 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 391619003477 metal binding site [ion binding]; metal-binding site 391619003478 putative dimer interface [polypeptide binding]; other site 391619003479 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 391619003480 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 391619003481 metal binding site [ion binding]; metal-binding site 391619003482 putative dimer interface [polypeptide binding]; other site 391619003483 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 391619003484 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 391619003485 metal binding site [ion binding]; metal-binding site 391619003486 putative dimer interface [polypeptide binding]; other site 391619003487 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 391619003488 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 391619003489 metal binding site [ion binding]; metal-binding site 391619003490 putative dimer interface [polypeptide binding]; other site 391619003491 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 391619003492 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 391619003493 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 391619003494 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 391619003495 molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361 391619003496 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391619003497 FeS/SAM binding site; other site 391619003498 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 391619003499 A new structural DNA glycosylase; Region: AlkD_like; cd06561 391619003500 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 391619003501 active site 391619003502 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 391619003503 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 391619003504 glutaminase active site [active] 391619003505 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 391619003506 dimer interface [polypeptide binding]; other site 391619003507 active site 391619003508 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 391619003509 dimer interface [polypeptide binding]; other site 391619003510 active site 391619003511 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353 391619003512 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 391619003513 Substrate binding site; other site 391619003514 Mg++ binding site; other site 391619003515 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 391619003516 active site 391619003517 substrate binding site [chemical binding]; other site 391619003518 CoA binding site [chemical binding]; other site 391619003519 phosphoglycolate phosphatase; Provisional; Region: PRK13222 391619003520 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 391619003521 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391619003522 motif II; other site 391619003523 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391619003524 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391619003525 catalytic residue [active] 391619003526 Hint domain; Region: Hint_2; pfam13403 391619003527 isovaleryl-CoA dehydrogenase; Region: PLN02519 391619003528 Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156 391619003529 substrate binding site [chemical binding]; other site 391619003530 FAD binding site [chemical binding]; other site 391619003531 catalytic base [active] 391619003532 OmpW family; Region: OmpW; cl17427 391619003533 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 391619003534 Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971 391619003535 active site 391619003536 acyl-activating enzyme (AAE) consensus motif; other site 391619003537 putative CoA binding site [chemical binding]; other site 391619003538 AMP binding site [chemical binding]; other site 391619003539 3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820 391619003540 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 391619003541 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391619003542 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 391619003543 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; pfam02785 391619003544 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 391619003545 carboxyltransferase (CT) interaction site; other site 391619003546 biotinylation site [posttranslational modification]; other site 391619003547 Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119 391619003548 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938 391619003549 active site 391619003550 catalytic residues [active] 391619003551 metal binding site [ion binding]; metal-binding site 391619003552 Predicted kinase [General function prediction only]; Region: COG0645 391619003553 AAA domain; Region: AAA_17; pfam13207 391619003554 enoyl-CoA hydratase; Provisional; Region: PRK07468 391619003555 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391619003556 substrate binding site [chemical binding]; other site 391619003557 oxyanion hole (OAH) forming residues; other site 391619003558 trimer interface [polypeptide binding]; other site 391619003559 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 391619003560 NADH dehydrogenase subunit B; Validated; Region: PRK06411 391619003561 NADH dehydrogenase subunit C; Provisional; Region: PRK06074 391619003562 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 391619003563 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 391619003564 NADH dehydrogenase subunit D; Validated; Region: PRK06075 391619003565 NADH dehydrogenase subunit E; Provisional; Region: PRK12373 391619003566 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 391619003567 putative dimer interface [polypeptide binding]; other site 391619003568 [2Fe-2S] cluster binding site [ion binding]; other site 391619003569 Uncharacterized conserved protein [Function unknown]; Region: COG3743 391619003570 NADH dehydrogenase I subunit F; Provisional; Region: PRK13596 391619003571 SLBB domain; Region: SLBB; pfam10531 391619003572 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 391619003573 NADH dehydrogenase subunit G; Validated; Region: PRK09130 391619003574 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391619003575 catalytic loop [active] 391619003576 iron binding site [ion binding]; other site 391619003577 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 391619003578 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 391619003579 molybdopterin cofactor binding site; other site 391619003580 Domain of unknown function (DUF1982); Region: DUF1982; pfam09326 391619003581 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 391619003582 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 391619003583 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 391619003584 4Fe-4S binding domain; Region: Fer4; pfam00037 391619003585 4Fe-4S binding domain; Region: Fer4; pfam00037 391619003586 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 391619003587 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 391619003588 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 391619003589 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 391619003590 hydrogenase 4 subunit D; Validated; Region: PRK06525 391619003591 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 391619003592 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 391619003593 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 391619003594 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 391619003595 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 391619003596 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 391619003597 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 391619003598 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 391619003599 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 391619003600 pantothenate kinase; Reviewed; Region: PRK13318 391619003601 mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595 391619003602 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 391619003603 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 391619003604 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 391619003605 DEAD-like helicases superfamily; Region: DEXDc; smart00487 391619003606 ATP binding site [chemical binding]; other site 391619003607 Mg++ binding site [ion binding]; other site 391619003608 motif III; other site 391619003609 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391619003610 nucleotide binding region [chemical binding]; other site 391619003611 ATP-binding site [chemical binding]; other site 391619003612 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 391619003613 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 391619003614 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 391619003615 G1 box; other site 391619003616 putative GEF interaction site [polypeptide binding]; other site 391619003617 GTP/Mg2+ binding site [chemical binding]; other site 391619003618 Switch I region; other site 391619003619 G2 box; other site 391619003620 G3 box; other site 391619003621 Switch II region; other site 391619003622 G4 box; other site 391619003623 G5 box; other site 391619003624 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 391619003625 SnoaL-like domain; Region: SnoaL_2; pfam12680 391619003626 Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081 391619003627 protein-splicing catalytic site; other site 391619003628 thioester formation/cholesterol transfer; other site 391619003629 short chain dehydrogenase; Provisional; Region: PRK08339 391619003630 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344 391619003631 putative NAD(P) binding site [chemical binding]; other site 391619003632 putative active site [active] 391619003633 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 391619003634 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391619003635 ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259 391619003636 Walker A/P-loop; other site 391619003637 ATP binding site [chemical binding]; other site 391619003638 Q-loop/lid; other site 391619003639 ABC transporter signature motif; other site 391619003640 Walker B; other site 391619003641 D-loop; other site 391619003642 H-loop/switch region; other site 391619003643 Predicted transcriptional regulator [Transcription]; Region: COG2378 391619003644 HTH domain; Region: HTH_11; pfam08279 391619003645 WYL domain; Region: WYL; pfam13280 391619003646 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 391619003647 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 391619003648 Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805 391619003649 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 391619003650 Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607 391619003651 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391619003652 Walker A motif; other site 391619003653 ATP binding site [chemical binding]; other site 391619003654 Walker B motif; other site 391619003655 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 391619003656 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 391619003657 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 391619003658 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 391619003659 Peptidase family M23; Region: Peptidase_M23; pfam01551 391619003660 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 391619003661 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391619003662 S-adenosylmethionine binding site [chemical binding]; other site 391619003663 stationary phase survival protein SurE; Provisional; Region: PRK13931 391619003664 classical (c) SDRs; Region: SDR_c; cd05233 391619003665 NAD(P) binding site [chemical binding]; other site 391619003666 active site 391619003667 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 391619003668 Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048 391619003669 amidophosphoribosyltransferase; Provisional; Region: PRK09123 391619003670 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 391619003671 active site 391619003672 tetramer interface [polypeptide binding]; other site 391619003673 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391619003674 active site 391619003675 Hint domain; Region: Hint_2; pfam13403 391619003676 Colicin V production protein; Region: Colicin_V; pfam02674 391619003677 DNA repair protein RadA; Provisional; Region: PRK11823 391619003678 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 391619003679 Walker A motif/ATP binding site; other site 391619003680 ATP binding site [chemical binding]; other site 391619003681 Walker B motif; other site 391619003682 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 391619003683 Paraquat-inducible protein A; Region: PqiA; pfam04403 391619003684 Protein of unknown function (DUF2971); Region: DUF2971; pfam11185 391619003685 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 391619003686 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 391619003687 Walker A/P-loop; other site 391619003688 ATP binding site [chemical binding]; other site 391619003689 Q-loop/lid; other site 391619003690 ABC transporter signature motif; other site 391619003691 Walker B; other site 391619003692 D-loop; other site 391619003693 H-loop/switch region; other site 391619003694 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 391619003695 Permease; Region: Permease; pfam02405 391619003696 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 391619003697 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 391619003698 active site 391619003699 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 391619003700 dimer interface [polypeptide binding]; other site 391619003701 substrate binding site [chemical binding]; other site 391619003702 catalytic residues [active] 391619003703 replicative DNA helicase; Provisional; Region: PRK09165 391619003704 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 391619003705 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 391619003706 Walker A motif; other site 391619003707 ATP binding site [chemical binding]; other site 391619003708 Walker B motif; other site 391619003709 DNA binding loops [nucleotide binding] 391619003710 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391619003711 active site 391619003712 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 391619003713 active site 391619003714 substrate binding pocket [chemical binding]; other site 391619003715 dimer interface [polypeptide binding]; other site 391619003716 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 391619003717 MoxR-like ATPases [General function prediction only]; Region: COG0714 391619003718 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391619003719 Walker A motif; other site 391619003720 ATP binding site [chemical binding]; other site 391619003721 Walker B motif; other site 391619003722 arginine finger; other site 391619003723 Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552 391619003724 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 391619003725 metal ion-dependent adhesion site (MIDAS); other site 391619003726 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 391619003727 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 391619003728 ligand binding site [chemical binding]; other site 391619003729 GTPase RsgA; Reviewed; Region: PRK01889 391619003730 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 391619003731 GTPase/Zn-binding domain interface [polypeptide binding]; other site 391619003732 GTP/Mg2+ binding site [chemical binding]; other site 391619003733 G4 box; other site 391619003734 G5 box; other site 391619003735 G1 box; other site 391619003736 Switch I region; other site 391619003737 G2 box; other site 391619003738 G3 box; other site 391619003739 Switch II region; other site 391619003740 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825 391619003741 Protein of unknown function (DUF2927); Region: DUF2927; pfam11150 391619003742 Predicted transcriptional regulator [Transcription]; Region: COG2944 391619003743 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 391619003744 salt bridge; other site 391619003745 non-specific DNA binding site [nucleotide binding]; other site 391619003746 sequence-specific DNA binding site [nucleotide binding]; other site 391619003747 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 391619003748 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391619003749 Walker A motif; other site 391619003750 ATP binding site [chemical binding]; other site 391619003751 Walker B motif; other site 391619003752 arginine finger; other site 391619003753 RNA polymerase-binding protein DksA; Region: dksA; TIGR02420 391619003754 2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654 391619003755 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 391619003756 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 391619003757 DNA-binding site [nucleotide binding]; DNA binding site 391619003758 RNA-binding motif; other site 391619003759 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 391619003760 putative catalytic site [active] 391619003761 putative phosphate binding site [ion binding]; other site 391619003762 active site 391619003763 metal binding site A [ion binding]; metal-binding site 391619003764 DNA binding site [nucleotide binding] 391619003765 putative AP binding site [nucleotide binding]; other site 391619003766 putative metal binding site B [ion binding]; other site 391619003767 Predicted membrane protein [Function unknown]; Region: COG2323 391619003768 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 391619003769 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 391619003770 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 391619003771 Zn2+ binding site [ion binding]; other site 391619003772 Mg2+ binding site [ion binding]; other site 391619003773 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 391619003774 YCII-related domain; Region: YCII; cl00999 391619003775 arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611 391619003776 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 391619003777 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 391619003778 active site 391619003779 HIGH motif; other site 391619003780 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391619003781 KMSK motif region; other site 391619003782 tRNA binding surface [nucleotide binding]; other site 391619003783 DALR anticodon binding domain; Region: DALR_1; smart00836 391619003784 anticodon binding site; other site 391619003785 Sporulation related domain; Region: SPOR; pfam05036 391619003786 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 391619003787 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971 391619003788 Rec8/ScpA/Scc1-like protein (kleisin family) [Replication, recombination, and repair]; Region: scpA; COG1354 391619003789 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 391619003790 2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559 391619003791 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 391619003792 trimer interface [polypeptide binding]; other site 391619003793 active site 391619003794 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493 391619003795 trimer interface [polypeptide binding]; other site 391619003796 active site 391619003797 Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765 391619003798 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 391619003799 DNA binding residues [nucleotide binding] 391619003800 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 391619003801 IHF dimer interface [polypeptide binding]; other site 391619003802 IHF - DNA interface [nucleotide binding]; other site 391619003803 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 391619003804 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 391619003805 dimer interface [polypeptide binding]; other site 391619003806 active site 391619003807 CoA binding pocket [chemical binding]; other site 391619003808 putative phosphate acyltransferase; Provisional; Region: PRK05331 391619003809 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 391619003810 Uncharacterized ACR, COG1399; Region: DUF177; pfam02620 391619003811 Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913 391619003812 SmpA / OmlA family; Region: SmpA_OmlA; cl17115 391619003813 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 391619003814 ABC transporter ATPase component; Reviewed; Region: PRK11147 391619003815 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 391619003816 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 391619003817 maltose O-acetyltransferase; Provisional; Region: PRK10092 391619003818 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 391619003819 active site 391619003820 substrate binding site [chemical binding]; other site 391619003821 trimer interface [polypeptide binding]; other site 391619003822 CoA binding site [chemical binding]; other site 391619003823 Uncharacterized conserved protein [Function unknown]; Region: COG3791 391619003824 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 391619003825 17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371 391619003826 NAD binding site [chemical binding]; other site 391619003827 homodimer interface [polypeptide binding]; other site 391619003828 homotetramer interface [polypeptide binding]; other site 391619003829 active site 391619003830 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 391619003831 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 391619003832 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 391619003833 active site 391619003834 HIGH motif; other site 391619003835 dimer interface [polypeptide binding]; other site 391619003836 KMSKS motif; other site 391619003837 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940 391619003838 RNA binding surface [nucleotide binding]; other site 391619003839 anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585 391619003840 hypothetical protein; Validated; Region: PRK00029 391619003841 Uncharacterized conserved protein [Function unknown]; Region: COG0397 391619003842 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391619003843 EamA-like transporter family; Region: EamA; cl17759 391619003844 EamA-like transporter family; Region: EamA; pfam00892 391619003845 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 391619003846 putative catalytic site [active] 391619003847 putative metal binding site [ion binding]; other site 391619003848 putative phosphate binding site [ion binding]; other site 391619003849 helicase 45; Provisional; Region: PTZ00424 391619003850 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 391619003851 ATP binding site [chemical binding]; other site 391619003852 Mg++ binding site [ion binding]; other site 391619003853 motif III; other site 391619003854 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391619003855 nucleotide binding region [chemical binding]; other site 391619003856 ATP-binding site [chemical binding]; other site 391619003857 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 391619003858 metal binding site 2 [ion binding]; metal-binding site 391619003859 putative DNA binding helix; other site 391619003860 metal binding site 1 [ion binding]; metal-binding site 391619003861 dimer interface [polypeptide binding]; other site 391619003862 structural Zn2+ binding site [ion binding]; other site 391619003863 enolase; Provisional; Region: eno; PRK00077 391619003864 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 391619003865 dimer interface [polypeptide binding]; other site 391619003866 metal binding site [ion binding]; metal-binding site 391619003867 substrate binding pocket [chemical binding]; other site 391619003868 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 391619003869 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391619003870 Coenzyme A binding pocket [chemical binding]; other site 391619003871 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 391619003872 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 391619003873 active site 391619003874 tetramer interface [polypeptide binding]; other site 391619003875 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 391619003876 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391619003877 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391619003878 catalytic residue [active] 391619003879 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 391619003880 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391619003881 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 391619003882 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 391619003883 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 391619003884 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 391619003885 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 391619003886 catalytic triad [active] 391619003887 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 391619003888 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 391619003889 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619003890 dimer interface [polypeptide binding]; other site 391619003891 conserved gate region; other site 391619003892 putative PBP binding loops; other site 391619003893 ABC-ATPase subunit interface; other site 391619003894 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 391619003895 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619003896 ABC-ATPase subunit interface; other site 391619003897 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391619003898 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391619003899 substrate binding pocket [chemical binding]; other site 391619003900 membrane-bound complex binding site; other site 391619003901 hinge residues; other site 391619003902 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 391619003903 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 391619003904 Walker A/P-loop; other site 391619003905 ATP binding site [chemical binding]; other site 391619003906 Q-loop/lid; other site 391619003907 ABC transporter signature motif; other site 391619003908 Walker B; other site 391619003909 D-loop; other site 391619003910 H-loop/switch region; other site 391619003911 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 391619003912 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 391619003913 putative metal binding site [ion binding]; other site 391619003914 tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313 391619003915 putative metal binding site [ion binding]; other site 391619003916 Protein of unknown function (DUF1330); Region: DUF1330; cl02288 391619003917 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 391619003918 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 391619003919 HIGH motif; other site 391619003920 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 391619003921 active site 391619003922 KMSKS motif; other site 391619003923 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 391619003924 tRNA binding surface [nucleotide binding]; other site 391619003925 anticodon binding site; other site 391619003926 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 391619003927 helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344 391619003928 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391619003929 putative DNA binding site [nucleotide binding]; other site 391619003930 putative Zn2+ binding site [ion binding]; other site 391619003931 AsnC family; Region: AsnC_trans_reg; pfam01037 391619003932 Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019 391619003933 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622 391619003934 dimer interface [polypeptide binding]; other site 391619003935 active site 391619003936 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 391619003937 catalytic residues [active] 391619003938 substrate binding site [chemical binding]; other site 391619003939 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 391619003940 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 391619003941 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 391619003942 Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994 391619003943 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391619003944 Coenzyme A binding pocket [chemical binding]; other site 391619003945 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 391619003946 CoenzymeA binding site [chemical binding]; other site 391619003947 subunit interaction site [polypeptide binding]; other site 391619003948 PHB binding site; other site 391619003949 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 391619003950 FAD binding site [chemical binding]; other site 391619003951 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 391619003952 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391619003953 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 391619003954 putative dimerization interface [polypeptide binding]; other site 391619003955 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 391619003956 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 391619003957 active site 391619003958 dimerization interface [polypeptide binding]; other site 391619003959 Uncharacterized conserved protein [Function unknown]; Region: COG3791 391619003960 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 391619003961 bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905 391619003962 Proline dehydrogenase; Region: Pro_dh; pfam01619 391619003963 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 391619003964 Glutamate binding site [chemical binding]; other site 391619003965 NAD binding site [chemical binding]; other site 391619003966 catalytic residues [active] 391619003967 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391619003968 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391619003969 dimerization interface [polypeptide binding]; other site 391619003970 putative DNA binding site [nucleotide binding]; other site 391619003971 putative Zn2+ binding site [ion binding]; other site 391619003972 AsnC family; Region: AsnC_trans_reg; pfam01037 391619003973 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391619003974 binding surface 391619003975 TPR motif; other site 391619003976 CHASE domain; Region: CHASE; cl01369 391619003977 PAS fold; Region: PAS_3; pfam08447 391619003978 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391619003979 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391619003980 dimer interface [polypeptide binding]; other site 391619003981 phosphorylation site [posttranslational modification] 391619003982 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391619003983 ATP binding site [chemical binding]; other site 391619003984 Mg2+ binding site [ion binding]; other site 391619003985 G-X-G motif; other site 391619003986 Response regulator receiver domain; Region: Response_reg; pfam00072 391619003987 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391619003988 active site 391619003989 phosphorylation site [posttranslational modification] 391619003990 intermolecular recognition site; other site 391619003991 dimerization interface [polypeptide binding]; other site 391619003992 PAS domain; Region: PAS_9; pfam13426 391619003993 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 391619003994 putative active site [active] 391619003995 heme pocket [chemical binding]; other site 391619003996 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 391619003997 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 391619003998 dimer interface [polypeptide binding]; other site 391619003999 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 391619004000 putative CheW interface [polypeptide binding]; other site 391619004001 acyl-CoA esterase; Provisional; Region: PRK10673 391619004002 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 391619004003 S-formylglutathione hydrolase; Region: PLN02442 391619004004 WHG domain; Region: WHG; pfam13305 391619004005 yiaA/B two helix domain; Region: YiaAB; cl01759 391619004006 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 391619004007 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 391619004008 dimer interface [polypeptide binding]; other site 391619004009 active site 391619004010 glycine-pyridoxal phosphate binding site [chemical binding]; other site 391619004011 folate binding site [chemical binding]; other site 391619004012 ATP-NAD kinase; Region: NAD_kinase; pfam01513 391619004013 inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761 391619004014 amidase; Provisional; Region: PRK07487 391619004015 Amidase; Region: Amidase; cl11426 391619004016 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 391619004017 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 391619004018 acyl-activating enzyme (AAE) consensus motif; other site 391619004019 putative AMP binding site [chemical binding]; other site 391619004020 putative active site [active] 391619004021 putative CoA binding site [chemical binding]; other site 391619004022 malic enzyme; Reviewed; Region: PRK12862 391619004023 Malic enzyme, N-terminal domain; Region: malic; pfam00390 391619004024 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 391619004025 putative NAD(P) binding site [chemical binding]; other site 391619004026 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 391619004027 Cupin domain; Region: Cupin_2; cl17218 391619004028 Cupin; Region: Cupin_6; pfam12852 391619004029 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 391619004030 active site 391619004031 catalytic motif [active] 391619004032 Zn binding site [ion binding]; other site 391619004033 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 391619004034 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 391619004035 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 391619004036 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734 391619004037 phosphopentomutase; Provisional; Region: PRK05362 391619004038 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 391619004039 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391619004040 active site 391619004041 Sporulation related domain; Region: SPOR; pfam05036 391619004042 acyl-CoA synthetase; Validated; Region: PRK08162 391619004043 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 391619004044 acyl-activating enzyme (AAE) consensus motif; other site 391619004045 putative active site [active] 391619004046 AMP binding site [chemical binding]; other site 391619004047 putative CoA binding site [chemical binding]; other site 391619004048 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 391619004049 Hint domain; Region: Hint_2; pfam13403 391619004050 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 391619004051 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391619004052 substrate binding site [chemical binding]; other site 391619004053 oxyanion hole (OAH) forming residues; other site 391619004054 trimer interface [polypeptide binding]; other site 391619004055 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 391619004056 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 391619004057 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 391619004058 acetyl-CoA acetyltransferase; Validated; Region: PRK08242 391619004059 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 391619004060 dimer interface [polypeptide binding]; other site 391619004061 active site 391619004062 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 391619004063 GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056 391619004064 putative C-terminal domain interface [polypeptide binding]; other site 391619004065 putative GSH binding site (G-site) [chemical binding]; other site 391619004066 putative dimer interface [polypeptide binding]; other site 391619004067 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 391619004068 N-terminal domain interface [polypeptide binding]; other site 391619004069 dimer interface [polypeptide binding]; other site 391619004070 substrate binding pocket (H-site) [chemical binding]; other site 391619004071 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391619004072 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391619004073 active site 391619004074 Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418 391619004075 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 391619004076 Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153 391619004077 FAD binding site [chemical binding]; other site 391619004078 substrate binding site [chemical binding]; other site 391619004079 catalytic residues [active] 391619004080 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 391619004081 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 391619004082 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 391619004083 DNA binding residues [nucleotide binding] 391619004084 putative dimer interface [polypeptide binding]; other site 391619004085 Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776 391619004086 DNA binding residues [nucleotide binding] 391619004087 Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789 391619004088 putative dimer interface [polypeptide binding]; other site 391619004089 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 391619004090 CoenzymeA binding site [chemical binding]; other site 391619004091 subunit interaction site [polypeptide binding]; other site 391619004092 PHB binding site; other site 391619004093 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 391619004094 CoenzymeA binding site [chemical binding]; other site 391619004095 subunit interaction site [polypeptide binding]; other site 391619004096 PHB binding site; other site 391619004097 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 391619004098 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 391619004099 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 391619004100 ArsC family; Region: ArsC; pfam03960 391619004101 catalytic residues [active] 391619004102 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 391619004103 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 391619004104 quinone interaction residues [chemical binding]; other site 391619004105 active site 391619004106 catalytic residues [active] 391619004107 FMN binding site [chemical binding]; other site 391619004108 substrate binding site [chemical binding]; other site 391619004109 Protein of unknown function (DUF952); Region: DUF952; pfam06108 391619004110 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 391619004111 CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409 391619004112 active site 391619004113 metal binding site [ion binding]; metal-binding site 391619004114 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 391619004115 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 391619004116 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 391619004117 MarR family; Region: MarR; pfam01047 391619004118 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 391619004119 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 391619004120 active site residue [active] 391619004121 pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169 391619004122 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391619004123 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 391619004124 selenophosphate synthetase; Provisional; Region: PRK00943 391619004125 dimerization interface [polypeptide binding]; other site 391619004126 putative ATP binding site [chemical binding]; other site 391619004127 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 391619004128 putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161 391619004129 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965 391619004130 putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666 391619004131 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 391619004132 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094 391619004133 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648 391619004134 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 391619004135 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 391619004136 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 391619004137 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 391619004138 active site residue [active] 391619004139 Serine hydrolase (FSH1); Region: FSH1; pfam03959 391619004140 glucosyltransferase MdoH; Provisional; Region: PRK05454 391619004141 active site 391619004142 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 391619004143 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 391619004144 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 391619004145 OpgC protein; Region: OpgC_C; pfam10129 391619004146 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 391619004147 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 391619004148 CoA-transferase family III; Region: CoA_transf_3; pfam02515 391619004149 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 391619004150 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391619004151 PYR/PP interface [polypeptide binding]; other site 391619004152 dimer interface [polypeptide binding]; other site 391619004153 TPP binding site [chemical binding]; other site 391619004154 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 391619004155 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 391619004156 TPP-binding site [chemical binding]; other site 391619004157 Domain of unknown function DUF302; Region: DUF302; pfam03625 391619004158 putative inner membrane protein; Provisional; Region: PRK11099 391619004159 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391619004160 dimerization interface [polypeptide binding]; other site 391619004161 putative DNA binding site [nucleotide binding]; other site 391619004162 putative Zn2+ binding site [ion binding]; other site 391619004163 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 391619004164 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 391619004165 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 391619004166 SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon dioxide...; Region: SoxW; cd02951 391619004167 catalytic residues [active] 391619004168 Cytochrome c; Region: Cytochrom_C; pfam00034 391619004169 sulfur oxidation protein SoxY; Provisional; Region: PRK07474 391619004170 Sulfur oxidation protein SoxY; Region: SoxY; pfam13501 391619004171 Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770 391619004172 Cytochrome c [Energy production and conversion]; Region: COG3258 391619004173 Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411 391619004174 active site 391619004175 metal binding site [ion binding]; metal-binding site 391619004176 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 391619004177 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 391619004178 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 391619004179 Moco binding site; other site 391619004180 metal coordination site [ion binding]; other site 391619004181 Cytochrome c; Region: Cytochrom_C; pfam00034 391619004182 Cytochrome c2 [Energy production and conversion]; Region: COG3474 391619004183 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 391619004184 putative chaperone; Provisional; Region: PRK11678 391619004185 nucleotide binding site [chemical binding]; other site 391619004186 putative NEF/HSP70 interaction site [polypeptide binding]; other site 391619004187 SBD interface [polypeptide binding]; other site 391619004188 Transglycosylase SLT domain; Region: SLT_2; pfam13406 391619004189 murein hydrolase B; Provisional; Region: PRK10760; cl17906 391619004190 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 391619004191 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 391619004192 conserved cys residue [active] 391619004193 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391619004194 Clp protease; Region: CLP_protease; pfam00574 391619004195 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 391619004196 oligomer interface [polypeptide binding]; other site 391619004197 active site residues [active] 391619004198 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 391619004199 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 391619004200 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391619004201 Walker A motif; other site 391619004202 ATP binding site [chemical binding]; other site 391619004203 Walker B motif; other site 391619004204 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 391619004205 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_6; cd06154 391619004206 homotrimer interaction site [polypeptide binding]; other site 391619004207 putative active site [active] 391619004208 NADH dehydrogenase; Validated; Region: PRK08183 391619004209 mce related protein; Region: MCE; pfam02470 391619004210 Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; pfam09923 391619004211 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 391619004212 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 391619004213 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391619004214 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 391619004215 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 391619004216 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 391619004217 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 391619004218 carboxyltransferase (CT) interaction site; other site 391619004219 biotinylation site [posttranslational modification]; other site 391619004220 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 391619004221 PAS domain; Region: PAS_9; pfam13426 391619004222 putative active site [active] 391619004223 heme pocket [chemical binding]; other site 391619004224 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391619004225 DNA binding residues [nucleotide binding] 391619004226 dimerization interface [polypeptide binding]; other site 391619004227 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391619004228 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 391619004229 Walker A/P-loop; other site 391619004230 ATP binding site [chemical binding]; other site 391619004231 Q-loop/lid; other site 391619004232 ABC transporter signature motif; other site 391619004233 Walker B; other site 391619004234 D-loop; other site 391619004235 H-loop/switch region; other site 391619004236 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391619004237 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 391619004238 Walker A/P-loop; other site 391619004239 ATP binding site [chemical binding]; other site 391619004240 Q-loop/lid; other site 391619004241 ABC transporter signature motif; other site 391619004242 Walker B; other site 391619004243 D-loop; other site 391619004244 H-loop/switch region; other site 391619004245 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 391619004246 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391619004247 TM-ABC transporter signature motif; other site 391619004248 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391619004249 TM-ABC transporter signature motif; other site 391619004250 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 391619004251 Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327 391619004252 putative ligand binding site [chemical binding]; other site 391619004253 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391619004254 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391619004255 non-specific DNA binding site [nucleotide binding]; other site 391619004256 salt bridge; other site 391619004257 sequence-specific DNA binding site [nucleotide binding]; other site 391619004258 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 391619004259 Response regulator receiver domain; Region: Response_reg; pfam00072 391619004260 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391619004261 active site 391619004262 phosphorylation site [posttranslational modification] 391619004263 intermolecular recognition site; other site 391619004264 dimerization interface [polypeptide binding]; other site 391619004265 Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591 391619004266 Na binding site [ion binding]; other site 391619004267 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391619004268 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391619004269 dimer interface [polypeptide binding]; other site 391619004270 phosphorylation site [posttranslational modification] 391619004271 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391619004272 ATP binding site [chemical binding]; other site 391619004273 Mg2+ binding site [ion binding]; other site 391619004274 G-X-G motif; other site 391619004275 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 391619004276 Putative phosphatase (DUF442); Region: DUF442; cl17385 391619004277 Predicted transporter component [General function prediction only]; Region: COG2391 391619004278 Sulphur transport; Region: Sulf_transp; pfam04143 391619004279 Predicted transporter component [General function prediction only]; Region: COG2391 391619004280 Sulphur transport; Region: Sulf_transp; pfam04143 391619004281 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 391619004282 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 391619004283 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 391619004284 homotrimer interaction site [polypeptide binding]; other site 391619004285 putative active site [active] 391619004286 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 391619004287 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391619004288 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391619004289 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 391619004290 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 391619004291 homodimer interface [polypeptide binding]; other site 391619004292 active site 391619004293 FMN binding site [chemical binding]; other site 391619004294 substrate binding site [chemical binding]; other site 391619004295 4Fe-4S binding domain; Region: Fer4; cl02805 391619004296 pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613 391619004297 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391619004298 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 391619004299 allantoate amidohydrolase; Reviewed; Region: PRK12893 391619004300 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 391619004301 active site 391619004302 metal binding site [ion binding]; metal-binding site 391619004303 dimer interface [polypeptide binding]; other site 391619004304 phenylhydantoinase; Validated; Region: PRK08323 391619004305 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 391619004306 tetramer interface [polypeptide binding]; other site 391619004307 active site 391619004308 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 391619004309 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 391619004310 Walker A/P-loop; other site 391619004311 ATP binding site [chemical binding]; other site 391619004312 Q-loop/lid; other site 391619004313 ABC transporter signature motif; other site 391619004314 Walker B; other site 391619004315 D-loop; other site 391619004316 H-loop/switch region; other site 391619004317 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 391619004318 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619004319 dimer interface [polypeptide binding]; other site 391619004320 conserved gate region; other site 391619004321 putative PBP binding loops; other site 391619004322 ABC-ATPase subunit interface; other site 391619004323 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 391619004324 Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528 391619004325 NMT1/THI5 like; Region: NMT1; pfam09084 391619004326 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 391619004327 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 391619004328 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 391619004329 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 391619004330 adenylate kinase; Reviewed; Region: adk; PRK00279 391619004331 AMP-binding site [chemical binding]; other site 391619004332 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 391619004333 acetyl-CoA synthetase; Provisional; Region: PRK00174 391619004334 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 391619004335 active site 391619004336 CoA binding site [chemical binding]; other site 391619004337 acyl-activating enzyme (AAE) consensus motif; other site 391619004338 AMP binding site [chemical binding]; other site 391619004339 acetate binding site [chemical binding]; other site 391619004340 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391619004341 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 391619004342 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 391619004343 DctM-like transporters; Region: DctM; pfam06808 391619004344 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 391619004345 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391619004346 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391619004347 active site 391619004348 phosphorylation site [posttranslational modification] 391619004349 intermolecular recognition site; other site 391619004350 dimerization interface [polypeptide binding]; other site 391619004351 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391619004352 DNA binding site [nucleotide binding] 391619004353 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 391619004354 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391619004355 ATP binding site [chemical binding]; other site 391619004356 Mg2+ binding site [ion binding]; other site 391619004357 G-X-G motif; other site 391619004358 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391619004359 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391619004360 putative substrate translocation pore; other site 391619004361 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 391619004362 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391619004363 HAMP domain; Region: HAMP; pfam00672 391619004364 dimerization interface [polypeptide binding]; other site 391619004365 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391619004366 dimer interface [polypeptide binding]; other site 391619004367 phosphorylation site [posttranslational modification] 391619004368 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391619004369 ATP binding site [chemical binding]; other site 391619004370 Mg2+ binding site [ion binding]; other site 391619004371 G-X-G motif; other site 391619004372 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391619004373 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391619004374 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 391619004375 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 391619004376 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391619004377 DNA-binding site [nucleotide binding]; DNA binding site 391619004378 UTRA domain; Region: UTRA; pfam07702 391619004379 alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565 391619004380 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 391619004381 active site 391619004382 dimer interface [polypeptide binding]; other site 391619004383 non-prolyl cis peptide bond; other site 391619004384 insertion regions; other site 391619004385 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 391619004386 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 391619004387 active site 391619004388 catalytic tetrad [active] 391619004389 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 391619004390 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 391619004391 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 391619004392 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 391619004393 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 391619004394 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391619004395 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 391619004396 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 391619004397 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 391619004398 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 391619004399 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391619004400 NAD(P) binding site [chemical binding]; other site 391619004401 active site 391619004402 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391619004403 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 391619004404 Walker A/P-loop; other site 391619004405 ATP binding site [chemical binding]; other site 391619004406 Q-loop/lid; other site 391619004407 ABC transporter signature motif; other site 391619004408 Walker B; other site 391619004409 D-loop; other site 391619004410 H-loop/switch region; other site 391619004411 TOBE domain; Region: TOBE_2; pfam08402 391619004412 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391619004413 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619004414 dimer interface [polypeptide binding]; other site 391619004415 conserved gate region; other site 391619004416 putative PBP binding loops; other site 391619004417 ABC-ATPase subunit interface; other site 391619004418 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 391619004419 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619004420 dimer interface [polypeptide binding]; other site 391619004421 conserved gate region; other site 391619004422 putative PBP binding loops; other site 391619004423 ABC-ATPase subunit interface; other site 391619004424 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391619004425 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391619004426 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391619004427 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391619004428 DNA binding site [nucleotide binding] 391619004429 domain linker motif; other site 391619004430 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 391619004431 dimerization interface [polypeptide binding]; other site 391619004432 ligand binding site [chemical binding]; other site 391619004433 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391619004434 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391619004435 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 391619004436 putative effector binding pocket; other site 391619004437 dimerization interface [polypeptide binding]; other site 391619004438 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 391619004439 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 391619004440 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 391619004441 dimerization interface [polypeptide binding]; other site 391619004442 putative ATP binding site [chemical binding]; other site 391619004443 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 391619004444 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 391619004445 active site 391619004446 substrate binding site [chemical binding]; other site 391619004447 cosubstrate binding site; other site 391619004448 catalytic site [active] 391619004449 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 391619004450 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 391619004451 catalytic site [active] 391619004452 putative active site [active] 391619004453 putative substrate binding site [chemical binding]; other site 391619004454 HRDC domain; Region: HRDC; pfam00570 391619004455 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 391619004456 Predicted transcriptional regulator [Transcription]; Region: COG2378 391619004457 HTH domain; Region: HTH_11; pfam08279 391619004458 WYL domain; Region: WYL; pfam13280 391619004459 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 391619004460 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 391619004461 C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207 391619004462 dimer interface [polypeptide binding]; other site 391619004463 N-terminal domain interface [polypeptide binding]; other site 391619004464 putative substrate binding pocket (H-site) [chemical binding]; other site 391619004465 Protein of unknown function (DUF1638); Region: DUF1638; pfam07796 391619004466 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 391619004467 B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070 391619004468 B12 binding site [chemical binding]; other site 391619004469 cobalt ligand [ion binding]; other site 391619004470 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 391619004471 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391619004472 FeS/SAM binding site; other site 391619004473 methionine synthase I; Validated; Region: PRK07534 391619004474 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 391619004475 Predicted integral membrane protein [Function unknown]; Region: COG0392 391619004476 Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924 391619004477 Domain of unknown function (DUF1476); Region: DUF1476; pfam07345 391619004478 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 391619004479 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 391619004480 ATP binding site [chemical binding]; other site 391619004481 active site 391619004482 substrate binding site [chemical binding]; other site 391619004483 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700 391619004484 phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619 391619004485 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 391619004486 putative active site [active] 391619004487 catalytic triad [active] 391619004488 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 391619004489 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391619004490 dimer interface [polypeptide binding]; other site 391619004491 phosphorylation site [posttranslational modification] 391619004492 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391619004493 ATP binding site [chemical binding]; other site 391619004494 Mg2+ binding site [ion binding]; other site 391619004495 G-X-G motif; other site 391619004496 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 391619004497 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391619004498 active site 391619004499 phosphorylation site [posttranslational modification] 391619004500 intermolecular recognition site; other site 391619004501 dimerization interface [polypeptide binding]; other site 391619004502 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391619004503 Walker A motif; other site 391619004504 ATP binding site [chemical binding]; other site 391619004505 Walker B motif; other site 391619004506 arginine finger; other site 391619004507 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 391619004508 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 391619004509 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 391619004510 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 391619004511 CPxP motif; other site 391619004512 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 391619004513 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683 391619004514 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 391619004515 Cytochrome P450; Region: p450; cl12078 391619004516 Ribbon-helix-helix domain; Region: RHH_4; pfam13467 391619004517 Domain of unknown function (DUF4169); Region: DUF4169; pfam13770 391619004518 fumarate hydratase; Reviewed; Region: fumC; PRK00485 391619004519 Class II fumarases; Region: Fumarase_classII; cd01362 391619004520 active site 391619004521 tetramer interface [polypeptide binding]; other site 391619004522 Stringent starvation protein B; Region: SspB; pfam04386 391619004523 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 391619004524 Chromate transporter; Region: Chromate_transp; pfam02417 391619004525 SnoaL-like domain; Region: SnoaL_2; pfam12680 391619004526 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 391619004527 HlyD family secretion protein; Region: HlyD_3; pfam13437 391619004528 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 391619004529 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 391619004530 Walker A/P-loop; other site 391619004531 ATP binding site [chemical binding]; other site 391619004532 Q-loop/lid; other site 391619004533 ABC transporter signature motif; other site 391619004534 Walker B; other site 391619004535 D-loop; other site 391619004536 H-loop/switch region; other site 391619004537 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 391619004538 FtsX-like permease family; Region: FtsX; pfam02687 391619004539 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 391619004540 FtsX-like permease family; Region: FtsX; pfam02687 391619004541 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal; Region: ACP_syn_III_C; cl17241 391619004542 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 391619004543 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 391619004544 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391619004545 3-oxoacyl-[acyl-carrier-protein]; Region: FabH; COG0332 391619004546 3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal; Region: ACP_syn_III_C; pfam08541 391619004547 pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099 391619004548 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839 391619004549 dimer interface [polypeptide binding]; other site 391619004550 active site 391619004551 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 391619004552 catalytic residues [active] 391619004553 substrate binding site [chemical binding]; other site 391619004554 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391619004555 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391619004556 active site 391619004557 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 391619004558 active site 391619004559 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 391619004560 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391619004561 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922 391619004562 acyl-activating enzyme (AAE) consensus motif; other site 391619004563 acyl-activating enzyme (AAE) consensus motif; other site 391619004564 putative AMP binding site [chemical binding]; other site 391619004565 putative active site [active] 391619004566 putative CoA binding site [chemical binding]; other site 391619004567 Phosphopantetheine attachment site; Region: PP-binding; cl09936 391619004568 D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945 391619004569 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 391619004570 acyl-activating enzyme (AAE) consensus motif; other site 391619004571 AMP binding site [chemical binding]; other site 391619004572 Cytochrome P450; Region: p450; cl12078 391619004573 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 391619004574 D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813 391619004575 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391619004576 acyl-activating enzyme (AAE) consensus motif; other site 391619004577 AMP binding site [chemical binding]; other site 391619004578 active site 391619004579 CoA binding site [chemical binding]; other site 391619004580 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 391619004581 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 391619004582 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 391619004583 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391619004584 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391619004585 active site 391619004586 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 391619004587 Helix-turn-helix domain; Region: HTH_18; pfam12833 391619004588 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391619004589 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 391619004590 Transcriptional regulators [Transcription]; Region: FadR; COG2186 391619004591 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391619004592 DNA-binding site [nucleotide binding]; DNA binding site 391619004593 FCD domain; Region: FCD; pfam07729 391619004594 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 391619004595 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 391619004596 NADP binding site [chemical binding]; other site 391619004597 dimer interface [polypeptide binding]; other site 391619004598 BCCT family transporter; Region: BCCT; pfam02028 391619004599 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 391619004600 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391619004601 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 391619004602 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391619004603 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391619004604 catalytic residue [active] 391619004605 Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415 391619004606 DNA photolyase; Region: DNA_photolyase; pfam00875 391619004607 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 391619004608 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391619004609 S-adenosylmethionine binding site [chemical binding]; other site 391619004610 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 391619004611 putative active site pocket [active] 391619004612 dimerization interface [polypeptide binding]; other site 391619004613 putative catalytic residue [active] 391619004614 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 391619004615 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 391619004616 dimer interface [polypeptide binding]; other site 391619004617 active site 391619004618 ADP-ribose binding site [chemical binding]; other site 391619004619 nudix motif; other site 391619004620 metal binding site [ion binding]; metal-binding site 391619004621 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 391619004622 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 391619004623 dimer interface [polypeptide binding]; other site 391619004624 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391619004625 catalytic residue [active] 391619004626 Protein of unknown function (DUF3772); Region: DUF3772; pfam12607 391619004627 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264 391619004628 Mechanosensitive ion channel; Region: MS_channel; pfam00924 391619004629 Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872 391619004630 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 391619004631 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391619004632 DNA binding site [nucleotide binding] 391619004633 domain linker motif; other site 391619004634 Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307 391619004635 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 391619004636 putative ligand binding site [chemical binding]; other site 391619004637 xylose isomerase; Provisional; Region: PRK05474 391619004638 xylose isomerase; Region: xylose_isom_A; TIGR02630 391619004639 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 391619004640 N- and C-terminal domain interface [polypeptide binding]; other site 391619004641 D-xylulose kinase; Region: XylB; TIGR01312 391619004642 active site 391619004643 MgATP binding site [chemical binding]; other site 391619004644 catalytic site [active] 391619004645 metal binding site [ion binding]; metal-binding site 391619004646 xylulose binding site [chemical binding]; other site 391619004647 homodimer interface [polypeptide binding]; other site 391619004648 Hint domain; Region: Hint_2; pfam13403 391619004649 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 391619004650 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 391619004651 Ligand binding site; other site 391619004652 metal-binding site 391619004653 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391619004654 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391619004655 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 391619004656 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391619004657 Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536 391619004658 Domain of unknown function DUF21; Region: DUF21; pfam01595 391619004659 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 391619004660 Transporter associated domain; Region: CorC_HlyC; smart01091 391619004661 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 391619004662 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391619004663 active site 391619004664 DNA binding site [nucleotide binding] 391619004665 Int/Topo IB signature motif; other site 391619004666 shikimate kinase; Provisional; Region: PRK13946 391619004667 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 391619004668 ADP binding site [chemical binding]; other site 391619004669 magnesium binding site [ion binding]; other site 391619004670 putative shikimate binding site; other site 391619004671 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 391619004672 Iron-containing alcohol dehydrogenase; Region: Fe-ADH; pfam00465 391619004673 active site 391619004674 dimer interface [polypeptide binding]; other site 391619004675 metal binding site [ion binding]; metal-binding site 391619004676 Nitrate and nitrite sensing; Region: NIT; pfam08376 391619004677 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 391619004678 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 391619004679 dimer interface [polypeptide binding]; other site 391619004680 putative CheW interface [polypeptide binding]; other site 391619004681 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 391619004682 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 391619004683 dimer interface [polypeptide binding]; other site 391619004684 ssDNA binding site [nucleotide binding]; other site 391619004685 tetramer (dimer of dimers) interface [polypeptide binding]; other site 391619004686 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 391619004687 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 391619004688 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391619004689 catalytic residue [active] 391619004690 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 391619004691 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391619004692 Walker A/P-loop; other site 391619004693 ATP binding site [chemical binding]; other site 391619004694 Q-loop/lid; other site 391619004695 ABC transporter signature motif; other site 391619004696 Walker B; other site 391619004697 D-loop; other site 391619004698 H-loop/switch region; other site 391619004699 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391619004700 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391619004701 Walker A/P-loop; other site 391619004702 ATP binding site [chemical binding]; other site 391619004703 Q-loop/lid; other site 391619004704 ABC transporter signature motif; other site 391619004705 Walker B; other site 391619004706 D-loop; other site 391619004707 H-loop/switch region; other site 391619004708 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391619004709 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 391619004710 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391619004711 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619004712 dimer interface [polypeptide binding]; other site 391619004713 conserved gate region; other site 391619004714 putative PBP binding loops; other site 391619004715 ABC-ATPase subunit interface; other site 391619004716 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391619004717 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 391619004718 Helix-turn-helix domain; Region: HTH_18; pfam12833 391619004719 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391619004720 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 391619004721 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 391619004722 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 391619004723 putative nucleotide binding site [chemical binding]; other site 391619004724 uridine monophosphate binding site [chemical binding]; other site 391619004725 homohexameric interface [polypeptide binding]; other site 391619004726 ribosome recycling factor; Reviewed; Region: frr; PRK00083 391619004727 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 391619004728 hinge region; other site 391619004729 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 391619004730 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 391619004731 catalytic residue [active] 391619004732 putative FPP diphosphate binding site; other site 391619004733 putative FPP binding hydrophobic cleft; other site 391619004734 dimer interface [polypeptide binding]; other site 391619004735 putative IPP diphosphate binding site; other site 391619004736 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 391619004737 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 391619004738 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 391619004739 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 391619004740 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 391619004741 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 391619004742 RIP metalloprotease RseP; Region: TIGR00054 391619004743 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 391619004744 active site 391619004745 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 391619004746 protein binding site [polypeptide binding]; other site 391619004747 putative substrate binding region [chemical binding]; other site 391619004748 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 391619004749 protein binding site [polypeptide binding]; other site 391619004750 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 391619004751 putative substrate binding region [chemical binding]; other site 391619004752 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 391619004753 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 391619004754 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 391619004755 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 391619004756 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 391619004757 Surface antigen; Region: Bac_surface_Ag; pfam01103 391619004758 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 391619004759 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 391619004760 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 391619004761 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 391619004762 active site 391619004763 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 391619004764 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 391619004765 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 391619004766 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 391619004767 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 391619004768 Ligand Binding Site [chemical binding]; other site 391619004769 Protein of unknown function (DUF1153); Region: DUF1153; pfam06627 391619004770 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391619004771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391619004772 active site 391619004773 phosphorylation site [posttranslational modification] 391619004774 intermolecular recognition site; other site 391619004775 dimerization interface [polypeptide binding]; other site 391619004776 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391619004777 DNA binding site [nucleotide binding] 391619004778 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 391619004779 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 391619004780 nucleotide binding pocket [chemical binding]; other site 391619004781 K-X-D-G motif; other site 391619004782 catalytic site [active] 391619004783 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 391619004784 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 391619004785 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 391619004786 Dimer interface [polypeptide binding]; other site 391619004787 BRCT sequence motif; other site 391619004788 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 391619004789 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 391619004790 generic binding surface II; other site 391619004791 ssDNA binding site; other site 391619004792 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391619004793 ATP binding site [chemical binding]; other site 391619004794 putative Mg++ binding site [ion binding]; other site 391619004795 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391619004796 nucleotide binding region [chemical binding]; other site 391619004797 ATP-binding site [chemical binding]; other site 391619004798 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 391619004799 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 391619004800 trimerization site [polypeptide binding]; other site 391619004801 active site 391619004802 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 391619004803 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 391619004804 Glutamyl- and glutaminyl-tRNA synthetases [Translation, ribosomal structure and biogenesis]; Region: GlnS; COG0008 391619004805 active site 391619004806 HIGH motif; other site 391619004807 nucleotide binding site [chemical binding]; other site 391619004808 active site 391619004809 KMSKS motif; other site 391619004810 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391619004811 S-adenosylmethionine binding site [chemical binding]; other site 391619004812 tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335 391619004813 Glucose inhibited division protein A; Region: GIDA; pfam01134 391619004814 enoyl-CoA hydratase; Validated; Region: PRK08139 391619004815 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391619004816 substrate binding site [chemical binding]; other site 391619004817 oxyanion hole (OAH) forming residues; other site 391619004818 trimer interface [polypeptide binding]; other site 391619004819 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 391619004820 CoenzymeA binding site [chemical binding]; other site 391619004821 subunit interaction site [polypeptide binding]; other site 391619004822 PHB binding site; other site 391619004823 Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656 391619004824 spermidine synthase; Provisional; Region: PRK00811 391619004825 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391619004826 S-adenosylmethionine binding site [chemical binding]; other site 391619004827 S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330 391619004828 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 391619004829 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 391619004830 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391619004831 DNA-binding site [nucleotide binding]; DNA binding site 391619004832 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391619004833 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391619004834 homodimer interface [polypeptide binding]; other site 391619004835 catalytic residue [active] 391619004836 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 391619004837 23S rRNA interface [nucleotide binding]; other site 391619004838 L3 interface [polypeptide binding]; other site 391619004839 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 391619004840 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391619004841 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391619004842 WHG domain; Region: WHG; pfam13305 391619004843 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 391619004844 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 391619004845 Homoserine O-succinyltransferase; Region: HTS; pfam04204 391619004846 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 391619004847 proposed active site lysine [active] 391619004848 conserved cys residue [active] 391619004849 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 391619004850 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391619004851 GMP synthase; Reviewed; Region: guaA; PRK00074 391619004852 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 391619004853 AMP/PPi binding site [chemical binding]; other site 391619004854 candidate oxyanion hole; other site 391619004855 catalytic triad [active] 391619004856 potential glutamine specificity residues [chemical binding]; other site 391619004857 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 391619004858 ATP Binding subdomain [chemical binding]; other site 391619004859 Ligand Binding sites [chemical binding]; other site 391619004860 Dimerization subdomain; other site 391619004861 Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253 391619004862 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 391619004863 catalytic triad [active] 391619004864 dimer interface [polypeptide binding]; other site 391619004865 lipoyl synthase; Provisional; Region: PRK05481 391619004866 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391619004867 FeS/SAM binding site; other site 391619004868 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 391619004869 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like3; cd05668 391619004870 metal binding site [ion binding]; metal-binding site 391619004871 putative dimer interface [polypeptide binding]; other site 391619004872 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 391619004873 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391619004874 active site 391619004875 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 391619004876 putative coenzyme Q binding site [chemical binding]; other site 391619004877 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 391619004878 Uncharacterized protein (competence- and mitomycin-induced) [General function prediction only]; Region: CinA; COG1546 391619004879 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 391619004880 tetramer interfaces [polypeptide binding]; other site 391619004881 binuclear metal-binding site [ion binding]; other site 391619004882 bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382 391619004883 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 391619004884 substrate binding site; other site 391619004885 dimer interface; other site 391619004886 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 391619004887 homotrimer interaction site [polypeptide binding]; other site 391619004888 zinc binding site [ion binding]; other site 391619004889 CDP-binding sites; other site 391619004890 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 391619004891 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 391619004892 FMN binding site [chemical binding]; other site 391619004893 active site 391619004894 catalytic residues [active] 391619004895 substrate binding site [chemical binding]; other site 391619004896 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 391619004897 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 391619004898 putative active site [active] 391619004899 heme pocket [chemical binding]; other site 391619004900 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391619004901 dimer interface [polypeptide binding]; other site 391619004902 phosphorylation site [posttranslational modification] 391619004903 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391619004904 ATP binding site [chemical binding]; other site 391619004905 G-X-G motif; other site 391619004906 nitrogen regulation protein NR(I); Region: ntrC; TIGR01818 391619004907 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391619004908 active site 391619004909 phosphorylation site [posttranslational modification] 391619004910 intermolecular recognition site; other site 391619004911 dimerization interface [polypeptide binding]; other site 391619004912 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391619004913 Walker A motif; other site 391619004914 ATP binding site [chemical binding]; other site 391619004915 Walker B motif; other site 391619004916 arginine finger; other site 391619004917 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 391619004918 Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000 391619004919 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 391619004920 dimerization interface [polypeptide binding]; other site 391619004921 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 391619004922 putative active site [active] 391619004923 heme pocket [chemical binding]; other site 391619004924 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391619004925 dimer interface [polypeptide binding]; other site 391619004926 phosphorylation site [posttranslational modification] 391619004927 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391619004928 ATP binding site [chemical binding]; other site 391619004929 Mg2+ binding site [ion binding]; other site 391619004930 G-X-G motif; other site 391619004931 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 391619004932 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391619004933 active site 391619004934 phosphorylation site [posttranslational modification] 391619004935 intermolecular recognition site; other site 391619004936 dimerization interface [polypeptide binding]; other site 391619004937 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391619004938 Walker A motif; other site 391619004939 ATP binding site [chemical binding]; other site 391619004940 Walker B motif; other site 391619004941 arginine finger; other site 391619004942 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 391619004943 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 391619004944 TrkA-N domain; Region: TrkA_N; pfam02254 391619004945 TrkA-C domain; Region: TrkA_C; pfam02080 391619004946 TrkA-N domain; Region: TrkA_N; pfam02254 391619004947 TrkA-C domain; Region: TrkA_C; pfam02080 391619004948 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 391619004949 Cation transport protein; Region: TrkH; cl17365 391619004950 bacterial Hfq-like; Region: Hfq; cd01716 391619004951 hexamer interface [polypeptide binding]; other site 391619004952 Sm1 motif; other site 391619004953 RNA binding site [nucleotide binding]; other site 391619004954 Sm2 motif; other site 391619004955 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 391619004956 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 391619004957 HflX GTPase family; Region: HflX; cd01878 391619004958 G1 box; other site 391619004959 GTP/Mg2+ binding site [chemical binding]; other site 391619004960 Switch I region; other site 391619004961 G2 box; other site 391619004962 G3 box; other site 391619004963 Switch II region; other site 391619004964 G4 box; other site 391619004965 G5 box; other site 391619004966 Protein related to penicillin acylase [General function prediction only]; Region: COG2366 391619004967 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 391619004968 Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747 391619004969 active site 391619004970 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 391619004971 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 391619004972 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cl01109 391619004973 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823 391619004974 dimer interface [polypeptide binding]; other site 391619004975 active site 391619004976 aspartate-rich active site metal binding site; other site 391619004977 allosteric magnesium binding site [ion binding]; other site 391619004978 Schiff base residues; other site 391619004979 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 391619004980 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 391619004981 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391619004982 ATP binding site [chemical binding]; other site 391619004983 putative Mg++ binding site [ion binding]; other site 391619004984 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391619004985 nucleotide binding region [chemical binding]; other site 391619004986 ATP-binding site [chemical binding]; other site 391619004987 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 391619004988 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391619004989 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 391619004990 putative substrate translocation pore; other site 391619004991 Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761 391619004992 DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024 391619004993 catalytic residues [active] 391619004994 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 391619004995 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391619004996 acyl-activating enzyme (AAE) consensus motif; other site 391619004997 AMP binding site [chemical binding]; other site 391619004998 active site 391619004999 CoA binding site [chemical binding]; other site 391619005000 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391619005001 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391619005002 non-specific DNA binding site [nucleotide binding]; other site 391619005003 salt bridge; other site 391619005004 sequence-specific DNA binding site [nucleotide binding]; other site 391619005005 Cupin domain; Region: Cupin_2; pfam07883 391619005006 Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580 391619005007 amphipathic channel; other site 391619005008 Asn-Pro-Ala signature motifs; other site 391619005009 Low molecular weight phosphatase family; Region: LMWPc; cd00115 391619005010 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 391619005011 active site 391619005012 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391619005013 dimerization interface [polypeptide binding]; other site 391619005014 putative DNA binding site [nucleotide binding]; other site 391619005015 putative Zn2+ binding site [ion binding]; other site 391619005016 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 391619005017 Low molecular weight phosphatase family; Region: LMWPc; cl00105 391619005018 active site 391619005019 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 391619005020 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 391619005021 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391619005022 3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963 391619005023 NAD(P) binding site [chemical binding]; other site 391619005024 active site 391619005025 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 391619005026 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 391619005027 active site 391619005028 nucleophile elbow; other site 391619005029 Uncharacterized conserved protein [Function unknown]; Region: COG2928 391619005030 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 391619005031 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 391619005032 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 391619005033 substrate binding site [chemical binding]; other site 391619005034 ATP binding site [chemical binding]; other site 391619005035 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 391619005036 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 391619005037 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 391619005038 thiamine phosphate binding site [chemical binding]; other site 391619005039 active site 391619005040 pyrophosphate binding site [ion binding]; other site 391619005041 rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565 391619005042 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 391619005043 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 391619005044 Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612 391619005045 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 391619005046 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 391619005047 active site 391619005048 Zn binding site [ion binding]; other site 391619005049 DNA gyrase subunit A; Validated; Region: PRK05560 391619005050 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 391619005051 CAP-like domain; other site 391619005052 active site 391619005053 primary dimer interface [polypeptide binding]; other site 391619005054 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 391619005055 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 391619005056 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 391619005057 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 391619005058 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 391619005059 Usg-like family; Region: Usg; pfam06233 391619005060 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 391619005061 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 391619005062 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 391619005063 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 391619005064 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 391619005065 putative active site [active] 391619005066 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 391619005067 active site 391619005068 Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894 391619005069 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391619005070 catalytic loop [active] 391619005071 iron binding site [ion binding]; other site 391619005072 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 391619005073 CoA-transferase family III; Region: CoA_transf_3; pfam02515 391619005074 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 391619005075 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 391619005076 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 391619005077 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 391619005078 active site 391619005079 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 391619005080 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391619005081 S-adenosylmethionine binding site [chemical binding]; other site 391619005082 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 391619005083 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391619005084 dimer interface [polypeptide binding]; other site 391619005085 phosphorylation site [posttranslational modification] 391619005086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391619005087 ATP binding site [chemical binding]; other site 391619005088 Mg2+ binding site [ion binding]; other site 391619005089 G-X-G motif; other site 391619005090 Response regulator receiver domain; Region: Response_reg; pfam00072 391619005091 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391619005092 active site 391619005093 phosphorylation site [posttranslational modification] 391619005094 intermolecular recognition site; other site 391619005095 dimerization interface [polypeptide binding]; other site 391619005096 recombinase A; Provisional; Region: recA; PRK09354 391619005097 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 391619005098 hexamer interface [polypeptide binding]; other site 391619005099 Walker A motif; other site 391619005100 ATP binding site [chemical binding]; other site 391619005101 Walker B motif; other site 391619005102 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 391619005103 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 391619005104 motif 1; other site 391619005105 active site 391619005106 motif 2; other site 391619005107 motif 3; other site 391619005108 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 391619005109 DHHA1 domain; Region: DHHA1; pfam02272 391619005110 Uncharacterized conserved protein [Function unknown]; Region: COG5470 391619005111 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 391619005112 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391619005113 Zn binding site [ion binding]; other site 391619005114 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 391619005115 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 391619005116 G1 box; other site 391619005117 putative GEF interaction site [polypeptide binding]; other site 391619005118 GTP/Mg2+ binding site [chemical binding]; other site 391619005119 Switch I region; other site 391619005120 G2 box; other site 391619005121 G3 box; other site 391619005122 Switch II region; other site 391619005123 G4 box; other site 391619005124 G5 box; other site 391619005125 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 391619005126 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 391619005127 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 391619005128 HD domain; Region: HD_3; pfam13023 391619005129 HD domain; Region: HD_3; pfam13023 391619005130 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945 391619005131 Transcriptional regulator; Region: Rrf2; cl17282 391619005132 Rrf2 family protein; Region: rrf2_super; TIGR00738 391619005133 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 391619005134 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 391619005135 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391619005136 catalytic residue [active] 391619005137 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 391619005138 putative ABC transporter; Region: ycf24; CHL00085 391619005139 Putative heavy-metal-binding; Region: YbjQ_1; cl00426 391619005140 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 391619005141 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 391619005142 Walker A/P-loop; other site 391619005143 ATP binding site [chemical binding]; other site 391619005144 Q-loop/lid; other site 391619005145 ABC transporter signature motif; other site 391619005146 Walker B; other site 391619005147 D-loop; other site 391619005148 H-loop/switch region; other site 391619005149 FeS assembly protein SufD; Region: sufD; TIGR01981 391619005150 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 391619005151 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 391619005152 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 391619005153 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391619005154 catalytic residue [active] 391619005155 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391619005156 binding surface 391619005157 Tetratricopeptide repeat; Region: TPR_16; pfam13432 391619005158 TPR motif; other site 391619005159 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832 391619005160 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 391619005161 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 391619005162 Uncharacterized conserved protein [Function unknown]; Region: COG3743 391619005163 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 391619005164 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 391619005165 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391619005166 GTPase CgtA; Reviewed; Region: obgE; PRK12299 391619005167 GTP1/OBG; Region: GTP1_OBG; pfam01018 391619005168 Obg GTPase; Region: Obg; cd01898 391619005169 G1 box; other site 391619005170 GTP/Mg2+ binding site [chemical binding]; other site 391619005171 Switch I region; other site 391619005172 G2 box; other site 391619005173 G3 box; other site 391619005174 Switch II region; other site 391619005175 G4 box; other site 391619005176 G5 box; other site 391619005177 gamma-glutamyl kinase; Provisional; Region: PRK05429 391619005178 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 391619005179 nucleotide binding site [chemical binding]; other site 391619005180 homotetrameric interface [polypeptide binding]; other site 391619005181 putative phosphate binding site [ion binding]; other site 391619005182 putative allosteric binding site; other site 391619005183 PUA domain; Region: PUA; pfam01472 391619005184 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 391619005185 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 391619005186 putative catalytic cysteine [active] 391619005187 Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090 391619005188 Protein of unknown function (DUF3553); Region: DUF3553; pfam12073 391619005189 Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496 391619005190 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 391619005191 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 391619005192 putative acyl-acceptor binding pocket; other site 391619005193 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 391619005194 rRNA interaction site [nucleotide binding]; other site 391619005195 S8 interaction site; other site 391619005196 putative laminin-1 binding site; other site 391619005197 elongation factor Ts; Provisional; Region: tsf; PRK09377 391619005198 UBA/TS-N domain; Region: UBA; pfam00627 391619005199 Elongation factor TS; Region: EF_TS; pfam00889 391619005200 Elongation factor TS; Region: EF_TS; pfam00889 391619005201 Autoinducer binding domain; Region: Autoind_bind; pfam03472 391619005202 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391619005203 DNA binding residues [nucleotide binding] 391619005204 dimerization interface [polypeptide binding]; other site 391619005205 Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466 391619005206 Dehydroquinase class II; Region: DHquinase_II; pfam01220 391619005207 active site 391619005208 trimer interface [polypeptide binding]; other site 391619005209 dimer interface [polypeptide binding]; other site 391619005210 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 391619005211 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 391619005212 NAD(P) binding site [chemical binding]; other site 391619005213 Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070 391619005214 2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730 391619005215 FMN binding site [chemical binding]; other site 391619005216 substrate binding site [chemical binding]; other site 391619005217 putative catalytic residue [active] 391619005218 Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154 391619005219 Phosphotransferase enzyme family; Region: APH; pfam01636 391619005220 putative active site [active] 391619005221 putative substrate binding site [chemical binding]; other site 391619005222 ATP binding site [chemical binding]; other site 391619005223 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 391619005224 Transcriptional regulator [Transcription]; Region: IclR; COG1414 391619005225 Bacterial transcriptional regulator; Region: IclR; pfam01614 391619005226 enoyl-CoA hydratase; Provisional; Region: PRK05870 391619005227 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391619005228 substrate binding site [chemical binding]; other site 391619005229 oxyanion hole (OAH) forming residues; other site 391619005230 trimer interface [polypeptide binding]; other site 391619005231 Beta-lactamase; Region: Beta-lactamase; pfam00144 391619005232 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 391619005233 Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946 391619005234 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 391619005235 active site 391619005236 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 391619005237 catalytic triad [active] 391619005238 dimer interface [polypeptide binding]; other site 391619005239 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 391619005240 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391619005241 NAD(P) binding site [chemical binding]; other site 391619005242 active site 391619005243 Glutaryl-CoA dehydrogenase; Region: GCD; cd01151 391619005244 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391619005245 FAD binding site [chemical binding]; other site 391619005246 substrate binding pocket [chemical binding]; other site 391619005247 catalytic base [active] 391619005248 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391619005249 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 391619005250 The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481 391619005251 dimerization interface [polypeptide binding]; other site 391619005252 substrate binding pocket [chemical binding]; other site 391619005253 phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154 391619005254 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391619005255 active site 391619005256 phosphorylation site [posttranslational modification] 391619005257 intermolecular recognition site; other site 391619005258 dimerization interface [polypeptide binding]; other site 391619005259 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391619005260 DNA binding site [nucleotide binding] 391619005261 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 391619005262 PhoU domain; Region: PhoU; pfam01895 391619005263 PhoU domain; Region: PhoU; pfam01895 391619005264 phosphate transporter ATP-binding protein; Provisional; Region: PRK14235 391619005265 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 391619005266 Walker A/P-loop; other site 391619005267 ATP binding site [chemical binding]; other site 391619005268 Q-loop/lid; other site 391619005269 ABC transporter signature motif; other site 391619005270 Walker B; other site 391619005271 D-loop; other site 391619005272 H-loop/switch region; other site 391619005273 Domain of unknown function (DUF3333); Region: DUF3333; pfam11812 391619005274 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581 391619005275 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619005276 dimer interface [polypeptide binding]; other site 391619005277 conserved gate region; other site 391619005278 putative PBP binding loops; other site 391619005279 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 391619005280 ABC-ATPase subunit interface; other site 391619005281 Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501 391619005282 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 391619005283 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619005284 dimer interface [polypeptide binding]; other site 391619005285 conserved gate region; other site 391619005286 putative PBP binding loops; other site 391619005287 ABC-ATPase subunit interface; other site 391619005288 PBP superfamily domain; Region: PBP_like_2; pfam12849 391619005289 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391619005290 dimer interface [polypeptide binding]; other site 391619005291 phosphorylation site [posttranslational modification] 391619005292 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391619005293 ATP binding site [chemical binding]; other site 391619005294 Mg2+ binding site [ion binding]; other site 391619005295 G-X-G motif; other site 391619005296 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 391619005297 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 391619005298 homodimer interface [polypeptide binding]; other site 391619005299 substrate-cofactor binding pocket; other site 391619005300 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391619005301 catalytic residue [active] 391619005302 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 391619005303 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 391619005304 trimer interface [polypeptide binding]; other site 391619005305 putative metal binding site [ion binding]; other site 391619005306 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 391619005307 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 391619005308 catalytic site [active] 391619005309 G-X2-G-X-G-K; other site 391619005310 hypothetical protein; Provisional; Region: PRK11820 391619005311 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 391619005312 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 391619005313 PAS domain; Region: PAS_5; pfam07310 391619005314 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388 391619005315 Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474 391619005316 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 391619005317 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 391619005318 conserved cys residue [active] 391619005319 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391619005320 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391619005321 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 391619005322 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 391619005323 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 391619005324 Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346 391619005325 putative ligand binding site [chemical binding]; other site 391619005326 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391619005327 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 391619005328 Walker A/P-loop; other site 391619005329 ATP binding site [chemical binding]; other site 391619005330 Q-loop/lid; other site 391619005331 ABC transporter signature motif; other site 391619005332 Walker B; other site 391619005333 D-loop; other site 391619005334 H-loop/switch region; other site 391619005335 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391619005336 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 391619005337 Walker A/P-loop; other site 391619005338 ATP binding site [chemical binding]; other site 391619005339 Q-loop/lid; other site 391619005340 ABC transporter signature motif; other site 391619005341 Walker B; other site 391619005342 D-loop; other site 391619005343 H-loop/switch region; other site 391619005344 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391619005345 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391619005346 TM-ABC transporter signature motif; other site 391619005347 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391619005348 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 391619005349 TM-ABC transporter signature motif; other site 391619005350 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 391619005351 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 391619005352 Walker A motif; other site 391619005353 ATP binding site [chemical binding]; other site 391619005354 Invasion associated locus B (IalB) protein; Region: IalB; pfam06776 391619005355 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 391619005356 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 391619005357 dimer interface [polypeptide binding]; other site 391619005358 active site 391619005359 acyl carrier protein; Provisional; Region: acpP; PRK00982 391619005360 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 391619005361 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 391619005362 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 391619005363 trimer interface [polypeptide binding]; other site 391619005364 active site 391619005365 UDP-GlcNAc binding site [chemical binding]; other site 391619005366 lipid binding site [chemical binding]; lipid-binding site 391619005367 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989 391619005368 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 391619005369 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 391619005370 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 391619005371 Peptidase M15; Region: Peptidase_M15_3; cl01194 391619005372 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 391619005373 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535 391619005374 substrate binding pocket [chemical binding]; other site 391619005375 dimer interface [polypeptide binding]; other site 391619005376 inhibitor binding site; inhibition site 391619005377 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246 391619005378 FAD binding site [chemical binding]; other site 391619005379 Virulence factor; Region: Virulence_fact; pfam13769 391619005380 exopolyphosphatase; Region: exo_poly_only; TIGR03706 391619005381 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 391619005382 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 391619005383 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391619005384 S-adenosylmethionine binding site [chemical binding]; other site 391619005385 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 391619005386 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 391619005387 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 391619005388 putative active site [active] 391619005389 catalytic site [active] 391619005390 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 391619005391 putative active site [active] 391619005392 catalytic site [active] 391619005393 Ion channel; Region: Ion_trans_2; pfam07885 391619005394 Maf_Ham1. Maf, a nucleotide binding protein, has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea. A Ham1-related protein from Methanococcus jannaschii is a novel NTPase that has been shown to hydrolyze nonstandard...; Region: Maf_Ham1; cl00276 391619005395 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 391619005396 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 391619005397 Walker A/P-loop; other site 391619005398 ATP binding site [chemical binding]; other site 391619005399 Q-loop/lid; other site 391619005400 ABC transporter signature motif; other site 391619005401 Walker B; other site 391619005402 D-loop; other site 391619005403 H-loop/switch region; other site 391619005404 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 391619005405 Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101 391619005406 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391619005407 Ligand Binding Site [chemical binding]; other site 391619005408 TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666 391619005409 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 391619005410 Domain of unknown function (DUF3394); Region: DUF3394; pfam11874 391619005411 TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358 391619005412 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 391619005413 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 391619005414 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 391619005415 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 391619005416 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 391619005417 catalytic loop [active] 391619005418 iron binding site [ion binding]; other site 391619005419 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 391619005420 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 391619005421 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 391619005422 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 391619005423 Ubiquitin-like proteins; Region: UBQ; cl00155 391619005424 charged pocket; other site 391619005425 hydrophobic patch; other site 391619005426 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 391619005427 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 391619005428 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 391619005429 intersubunit interface [polypeptide binding]; other site 391619005430 active site 391619005431 Zn2+ binding site [ion binding]; other site 391619005432 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 391619005433 active site 391619005434 dimer interface [polypeptide binding]; other site 391619005435 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 391619005436 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 391619005437 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 391619005438 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391619005439 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619005440 dimer interface [polypeptide binding]; other site 391619005441 conserved gate region; other site 391619005442 putative PBP binding loops; other site 391619005443 ABC-ATPase subunit interface; other site 391619005444 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 391619005445 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619005446 dimer interface [polypeptide binding]; other site 391619005447 conserved gate region; other site 391619005448 ABC-ATPase subunit interface; other site 391619005449 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 391619005450 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391619005451 Walker A/P-loop; other site 391619005452 ATP binding site [chemical binding]; other site 391619005453 Q-loop/lid; other site 391619005454 ABC transporter signature motif; other site 391619005455 Walker B; other site 391619005456 D-loop; other site 391619005457 H-loop/switch region; other site 391619005458 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391619005459 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 391619005460 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391619005461 Walker A/P-loop; other site 391619005462 ATP binding site [chemical binding]; other site 391619005463 Q-loop/lid; other site 391619005464 ABC transporter signature motif; other site 391619005465 Walker B; other site 391619005466 D-loop; other site 391619005467 H-loop/switch region; other site 391619005468 HD domain; Region: HD_5; pfam13487 391619005469 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 391619005470 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 391619005471 Zn2+ binding site [ion binding]; other site 391619005472 Mg2+ binding site [ion binding]; other site 391619005473 Predicted membrane protein [Function unknown]; Region: COG1238 391619005474 Disulfide bond formation protein DsbB; Region: DsbB; pfam02600 391619005475 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391619005476 AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404 391619005477 AsnC family; Region: AsnC_trans_reg; pfam01037 391619005478 Arginase family; Region: Arginase; cd09989 391619005479 active site 391619005480 Mn binding site [ion binding]; other site 391619005481 oligomer interface [polypeptide binding]; other site 391619005482 Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874 391619005483 Amidinotransferase; Region: Amidinotransf; pfam02274 391619005484 ornithine cyclodeaminase; Validated; Region: PRK07589 391619005485 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 391619005486 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 391619005487 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 391619005488 active site 391619005489 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 391619005490 pseudouridine synthase; Region: TIGR00093 391619005491 active site 391619005492 putative hydrolase; Provisional; Region: PRK11460 391619005493 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 391619005494 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122 391619005495 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 391619005496 helix-hairpin-helix signature motif; other site 391619005497 substrate binding pocket [chemical binding]; other site 391619005498 active site 391619005499 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391619005500 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 391619005501 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 391619005502 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 391619005503 active site 391619005504 catalytic residues [active] 391619005505 metal binding site [ion binding]; metal-binding site 391619005506 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 391619005507 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 391619005508 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391619005509 active site 391619005510 HIGH motif; other site 391619005511 nucleotide binding site [chemical binding]; other site 391619005512 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 391619005513 KMSKS motif; other site 391619005514 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 391619005515 tRNA binding surface [nucleotide binding]; other site 391619005516 anticodon binding site; other site 391619005517 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 391619005518 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 391619005519 Trimethylamine:corrinoid methyltransferase [Coenzyme metabolism]; Region: COG5598 391619005520 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 391619005521 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 391619005522 active site 391619005523 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391619005524 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 391619005525 Walker A/P-loop; other site 391619005526 ATP binding site [chemical binding]; other site 391619005527 Q-loop/lid; other site 391619005528 ABC transporter signature motif; other site 391619005529 Walker B; other site 391619005530 D-loop; other site 391619005531 H-loop/switch region; other site 391619005532 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391619005533 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 391619005534 Walker A/P-loop; other site 391619005535 ATP binding site [chemical binding]; other site 391619005536 Q-loop/lid; other site 391619005537 ABC transporter signature motif; other site 391619005538 Walker B; other site 391619005539 D-loop; other site 391619005540 H-loop/switch region; other site 391619005541 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391619005542 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391619005543 TM-ABC transporter signature motif; other site 391619005544 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391619005545 TM-ABC transporter signature motif; other site 391619005546 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 391619005547 Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359 391619005548 putative ligand binding site [chemical binding]; other site 391619005549 Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201 391619005550 CheB methylesterase; Region: CheB_methylest; pfam01339 391619005551 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 391619005552 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 391619005553 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 391619005554 PAS domain; Region: PAS_10; pfam13596 391619005555 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 391619005556 PAS fold; Region: PAS_3; pfam08447 391619005557 putative active site [active] 391619005558 heme pocket [chemical binding]; other site 391619005559 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 391619005560 TPP-binding site [chemical binding]; other site 391619005561 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 391619005562 PYR/PP interface [polypeptide binding]; other site 391619005563 dimer interface [polypeptide binding]; other site 391619005564 TPP binding site [chemical binding]; other site 391619005565 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 391619005566 methionine gamma-lyase; Provisional; Region: PRK07503 391619005567 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 391619005568 homodimer interface [polypeptide binding]; other site 391619005569 substrate-cofactor binding pocket; other site 391619005570 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391619005571 catalytic residue [active] 391619005572 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391619005573 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391619005574 dimerization interface [polypeptide binding]; other site 391619005575 putative DNA binding site [nucleotide binding]; other site 391619005576 putative Zn2+ binding site [ion binding]; other site 391619005577 AsnC family; Region: AsnC_trans_reg; pfam01037 391619005578 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 391619005579 cyclase homology domain; Region: CHD; cd07302 391619005580 nucleotidyl binding site; other site 391619005581 metal binding site [ion binding]; metal-binding site 391619005582 dimer interface [polypeptide binding]; other site 391619005583 Predicted integral membrane protein [Function unknown]; Region: COG5616 391619005584 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391619005585 binding surface 391619005586 TPR repeat; Region: TPR_11; pfam13414 391619005587 TPR motif; other site 391619005588 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391619005589 TPR motif; other site 391619005590 binding surface 391619005591 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 391619005592 active site 391619005593 N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221 391619005594 putative active cleft [active] 391619005595 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 391619005596 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 391619005597 Walker A/P-loop; other site 391619005598 ATP binding site [chemical binding]; other site 391619005599 Q-loop/lid; other site 391619005600 ABC transporter signature motif; other site 391619005601 Walker B; other site 391619005602 D-loop; other site 391619005603 H-loop/switch region; other site 391619005604 TOBE domain; Region: TOBE_2; pfam08402 391619005605 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391619005606 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619005607 dimer interface [polypeptide binding]; other site 391619005608 conserved gate region; other site 391619005609 putative PBP binding loops; other site 391619005610 ABC-ATPase subunit interface; other site 391619005611 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619005612 dimer interface [polypeptide binding]; other site 391619005613 conserved gate region; other site 391619005614 putative PBP binding loops; other site 391619005615 ABC-ATPase subunit interface; other site 391619005616 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391619005617 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391619005618 hypothetical protein; Provisional; Region: PRK05968 391619005619 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391619005620 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391619005621 catalytic residue [active] 391619005622 Transcriptional regulators [Transcription]; Region: FadR; COG2186 391619005623 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391619005624 DNA-binding site [nucleotide binding]; DNA binding site 391619005625 FCD domain; Region: FCD; pfam07729 391619005626 ammonium transporter; Region: amt; TIGR00836 391619005627 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391619005628 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 391619005629 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391619005630 metal binding site [ion binding]; metal-binding site 391619005631 active site 391619005632 I-site; other site 391619005633 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 391619005634 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391619005635 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391619005636 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562 391619005637 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 391619005638 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 391619005639 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 391619005640 active site 391619005641 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 391619005642 TSCPD domain; Region: TSCPD; pfam12637 391619005643 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 391619005644 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 391619005645 DNA-binding site [nucleotide binding]; DNA binding site 391619005646 RNA-binding motif; other site 391619005647 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 391619005648 DNA-binding site [nucleotide binding]; DNA binding site 391619005649 RNA-binding motif; other site 391619005650 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 391619005651 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 391619005652 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 391619005653 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159 391619005654 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 391619005655 NAD binding site [chemical binding]; other site 391619005656 homotetramer interface [polypeptide binding]; other site 391619005657 homodimer interface [polypeptide binding]; other site 391619005658 substrate binding site [chemical binding]; other site 391619005659 active site 391619005660 LysE type translocator; Region: LysE; cl00565 391619005661 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391619005662 active site 391619005663 hypothetical protein; Provisional; Region: PRK07550 391619005664 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391619005665 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391619005666 homodimer interface [polypeptide binding]; other site 391619005667 catalytic residue [active] 391619005668 SurA N-terminal domain; Region: SurA_N_3; cl07813 391619005669 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 391619005670 anthranilate synthase component I; Provisional; Region: PRK13573 391619005671 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 391619005672 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 391619005673 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 391619005674 NodB motif; other site 391619005675 putative active site [active] 391619005676 putative catalytic site [active] 391619005677 Zn binding site [ion binding]; other site 391619005678 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 391619005679 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 391619005680 glutamine binding [chemical binding]; other site 391619005681 catalytic triad [active] 391619005682 anthranilate phosphoribosyltransferase; Region: trpD; TIGR01245 391619005683 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 391619005684 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 391619005685 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 391619005686 ligand binding site [chemical binding]; other site 391619005687 active site 391619005688 UGI interface [polypeptide binding]; other site 391619005689 catalytic site [active] 391619005690 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 391619005691 active site 391619005692 ribulose/triose binding site [chemical binding]; other site 391619005693 phosphate binding site [ion binding]; other site 391619005694 substrate (anthranilate) binding pocket [chemical binding]; other site 391619005695 product (indole) binding pocket [chemical binding]; other site 391619005696 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 391619005697 trimer interface [polypeptide binding]; other site 391619005698 dimer interface [polypeptide binding]; other site 391619005699 putative active site [active] 391619005700 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 391619005701 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 391619005702 dimer interface [polypeptide binding]; other site 391619005703 putative functional site; other site 391619005704 putative MPT binding site; other site 391619005705 LexA repressor; Validated; Region: PRK00215 391619005706 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 391619005707 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 391619005708 Catalytic site [active] 391619005709 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 391619005710 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 391619005711 Competence protein; Region: Competence; pfam03772 391619005712 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 391619005713 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391619005714 active site 391619005715 HIGH motif; other site 391619005716 nucleotide binding site [chemical binding]; other site 391619005717 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 391619005718 active site 391619005719 KMSKS motif; other site 391619005720 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 391619005721 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 391619005722 dimer interface [polypeptide binding]; other site 391619005723 active site 391619005724 citrylCoA binding site [chemical binding]; other site 391619005725 NADH binding [chemical binding]; other site 391619005726 cationic pore residues; other site 391619005727 oxalacetate/citrate binding site [chemical binding]; other site 391619005728 coenzyme A binding site [chemical binding]; other site 391619005729 catalytic triad [active] 391619005730 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 391619005731 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 391619005732 enoyl-CoA hydratase; Provisional; Region: PRK08140 391619005733 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391619005734 substrate binding site [chemical binding]; other site 391619005735 oxyanion hole (OAH) forming residues; other site 391619005736 trimer interface [polypeptide binding]; other site 391619005737 Cytochrome C biogenesis protein; Region: CcmH; pfam03918 391619005738 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138 391619005739 Protein of unknown function (DUF3154); Region: DUF3154; pfam11351 391619005740 Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838 391619005741 Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374 391619005742 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254 391619005743 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 391619005744 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 391619005745 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 391619005746 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986 391619005747 putative acyl-acceptor binding pocket; other site 391619005748 indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193 391619005749 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 391619005750 dimer interface [polypeptide binding]; other site 391619005751 PYR/PP interface [polypeptide binding]; other site 391619005752 TPP binding site [chemical binding]; other site 391619005753 substrate binding site [chemical binding]; other site 391619005754 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 391619005755 TPP-binding site [chemical binding]; other site 391619005756 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 391619005757 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391619005758 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391619005759 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 391619005760 putative effector binding pocket; other site 391619005761 dimerization interface [polypeptide binding]; other site 391619005762 phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213 391619005763 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 391619005764 dimerization interface [polypeptide binding]; other site 391619005765 ATP binding site [chemical binding]; other site 391619005766 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 391619005767 dimerization interface [polypeptide binding]; other site 391619005768 ATP binding site [chemical binding]; other site 391619005769 hypothetical protein; Provisional; Region: PRK09866 391619005770 Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271 391619005771 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 391619005772 putative GSH binding site [chemical binding]; other site 391619005773 catalytic residues [active] 391619005774 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 391619005775 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391619005776 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391619005777 Cell division protein ZapA; Region: ZapA; pfam05164 391619005778 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 391619005779 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 391619005780 TPP-binding site [chemical binding]; other site 391619005781 dimer interface [polypeptide binding]; other site 391619005782 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 391619005783 PYR/PP interface [polypeptide binding]; other site 391619005784 dimer interface [polypeptide binding]; other site 391619005785 TPP binding site [chemical binding]; other site 391619005786 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 391619005787 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354 391619005788 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 391619005789 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 391619005790 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 391619005791 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 391619005792 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 391619005793 active site 391619005794 (T/H)XGH motif; other site 391619005795 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 391619005796 FOG: CBS domain [General function prediction only]; Region: COG0517 391619005797 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391619005798 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391619005799 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 391619005800 dimerization interface [polypeptide binding]; other site 391619005801 Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085 391619005802 methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722 391619005803 tetrameric interface [polypeptide binding]; other site 391619005804 NAD binding site [chemical binding]; other site 391619005805 catalytic residues [active] 391619005806 Fatty acid desaturase; Region: FA_desaturase; pfam00487 391619005807 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 391619005808 putative di-iron ligands [ion binding]; other site 391619005809 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 391619005810 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 391619005811 TPR repeat; Region: TPR_11; pfam13414 391619005812 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391619005813 binding surface 391619005814 TPR motif; other site 391619005815 Predicted O-linked N-acetylglucosamine transferase, SPINDLY family [Posttranslational modification, protein turnover, chaperones]; Region: Spy; COG3914 391619005816 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 391619005817 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391619005818 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391619005819 active site 391619005820 3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617 391619005821 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391619005822 substrate binding site [chemical binding]; other site 391619005823 oxyanion hole (OAH) forming residues; other site 391619005824 trimer interface [polypeptide binding]; other site 391619005825 2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766 391619005826 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 391619005827 3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692 391619005828 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 391619005829 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 391619005830 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 391619005831 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 391619005832 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391619005833 putative substrate translocation pore; other site 391619005834 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 391619005835 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391619005836 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391619005837 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 391619005838 Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041 391619005839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391619005840 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391619005841 putative substrate translocation pore; other site 391619005842 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 391619005843 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 391619005844 Protein of unknown function; Region: DUF3971; pfam13116 391619005845 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 391619005846 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 391619005847 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 391619005848 catalytic triad [active] 391619005849 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 391619005850 dinuclear metal binding motif [ion binding]; other site 391619005851 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 391619005852 Peptidase family M23; Region: Peptidase_M23; pfam01551 391619005853 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 391619005854 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 391619005855 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 391619005856 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 391619005857 Protein of unknown function (DUF3179); Region: DUF3179; pfam11376 391619005858 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 391619005859 active site 391619005860 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 391619005861 active site 391619005862 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 391619005863 Phosphoglycerate kinase; Region: PGK; pfam00162 391619005864 substrate binding site [chemical binding]; other site 391619005865 hinge regions; other site 391619005866 ADP binding site [chemical binding]; other site 391619005867 catalytic site [active] 391619005868 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 391619005869 Septum formation initiator; Region: DivIC; pfam04977 391619005870 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 391619005871 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 391619005872 tetramer interface [polypeptide binding]; other site 391619005873 TPP-binding site [chemical binding]; other site 391619005874 heterodimer interface [polypeptide binding]; other site 391619005875 phosphorylation loop region [posttranslational modification] 391619005876 pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892 391619005877 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 391619005878 E3 interaction surface; other site 391619005879 lipoyl attachment site [posttranslational modification]; other site 391619005880 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 391619005881 alpha subunit interface [polypeptide binding]; other site 391619005882 TPP binding site [chemical binding]; other site 391619005883 heterodimer interface [polypeptide binding]; other site 391619005884 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 391619005885 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 391619005886 pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349 391619005887 E3 interaction surface; other site 391619005888 lipoyl attachment site [posttranslational modification]; other site 391619005889 e3 binding domain; Region: E3_binding; pfam02817 391619005890 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 391619005891 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 391619005892 active site 391619005893 substrate binding site [chemical binding]; other site 391619005894 trimer interface [polypeptide binding]; other site 391619005895 CoA binding site [chemical binding]; other site 391619005896 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 391619005897 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815 391619005898 active site 391619005899 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 391619005900 dimer interface [polypeptide binding]; other site 391619005901 substrate binding site [chemical binding]; other site 391619005902 catalytic residue [active] 391619005903 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 391619005904 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 391619005905 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 391619005906 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 391619005907 putative switch regulator; other site 391619005908 non-specific DNA interactions [nucleotide binding]; other site 391619005909 DNA binding site [nucleotide binding] 391619005910 sequence specific DNA binding site [nucleotide binding]; other site 391619005911 putative cAMP binding site [chemical binding]; other site 391619005912 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 391619005913 serine acetyltransferase; Provisional; Region: cysE; PRK11132 391619005914 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 391619005915 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 391619005916 trimer interface [polypeptide binding]; other site 391619005917 active site 391619005918 substrate binding site [chemical binding]; other site 391619005919 CoA binding site [chemical binding]; other site 391619005920 GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547 391619005921 Putative phage tail protein; Region: Phage-tail_3; pfam13550 391619005922 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 391619005923 NlpC/P60 family; Region: NLPC_P60; cl17555 391619005924 Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931 391619005925 phage conserved hypothetical protein BR0599; Region: phg_TIGR02218 391619005926 Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356 391619005927 Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343 391619005928 Phage-related minor tail protein [Function unknown]; Region: COG5281 391619005929 phage conserved hypothetical protein; Region: phage_TIGR02216 391619005930 Protein of unknown function (DUF3356); Region: DUF3356; pfam11836 391619005931 Phage major tail protein 2; Region: Phage_tail_2; cl11463 391619005932 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 391619005933 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 391619005934 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 391619005935 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 391619005936 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 391619005937 oligomerization interface [polypeptide binding]; other site 391619005938 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 391619005939 Phage capsid family; Region: Phage_capsid; pfam05065 391619005940 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 391619005941 Phage-related protein [Function unknown]; Region: COG4695 391619005942 Phage portal protein; Region: Phage_portal; pfam04860 391619005943 Uncharacterized conserved protein [Function unknown]; Region: COG5323 391619005944 Terminase-like family; Region: Terminase_6; pfam03237 391619005945 YceG-like family; Region: YceG; pfam02618 391619005946 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 391619005947 dimerization interface [polypeptide binding]; other site 391619005948 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 391619005949 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 391619005950 dimer interface [polypeptide binding]; other site 391619005951 active site 391619005952 PilZ domain; Region: PilZ; pfam07238 391619005953 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 391619005954 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 391619005955 catalytic residues [active] 391619005956 acyl carrier protein; Provisional; Region: acpP; PRK00982 391619005957 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 391619005958 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 391619005959 NAD(P) binding site [chemical binding]; other site 391619005960 homotetramer interface [polypeptide binding]; other site 391619005961 homodimer interface [polypeptide binding]; other site 391619005962 active site 391619005963 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 391619005964 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 391619005965 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 391619005966 YceI-like domain; Region: YceI; pfam04264 391619005967 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391619005968 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391619005969 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391619005970 aromatic amino acid exporter; Provisional; Region: PRK11689 391619005971 EamA-like transporter family; Region: EamA; pfam00892 391619005972 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 391619005973 dimer interface [polypeptide binding]; other site 391619005974 putative tRNA-binding site [nucleotide binding]; other site 391619005975 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 391619005976 tartrate dehydrogenase; Region: TTC; TIGR02089 391619005977 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391619005978 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 391619005979 DNA binding residues [nucleotide binding] 391619005980 Integrase core domain; Region: rve; pfam00665 391619005981 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 391619005982 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391619005983 Walker A motif; other site 391619005984 ATP binding site [chemical binding]; other site 391619005985 Walker B motif; other site 391619005986 arginine finger; other site 391619005987 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 391619005988 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 391619005989 Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731 391619005990 putative NAD(P) binding site [chemical binding]; other site 391619005991 homodimer interface [polypeptide binding]; other site 391619005992 Uncharacterized conserved protein [Function unknown]; Region: COG2353 391619005993 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 391619005994 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 391619005995 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 391619005996 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 391619005997 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 391619005998 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 391619005999 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 391619006000 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391619006001 catalytic residue [active] 391619006002 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 391619006003 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 391619006004 active site 391619006005 metal binding site [ion binding]; metal-binding site 391619006006 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 391619006007 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 391619006008 trigger factor; Provisional; Region: tig; PRK01490 391619006009 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 391619006010 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 391619006011 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 391619006012 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 391619006013 HAMP domain; Region: HAMP; pfam00672 391619006014 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 391619006015 dimer interface [polypeptide binding]; other site 391619006016 Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015 391619006017 putative CheW interface [polypeptide binding]; other site 391619006018 RNA helicase; Region: RNA_helicase; pfam00910 391619006019 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 391619006020 Phage Tail Protein X; Region: Phage_tail_X; cl02088 391619006021 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 391619006022 Phage-related tail protein [Function unknown]; Region: COG5283 391619006023 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 391619006024 Phage tail tube protein FII; Region: Phage_tube; pfam04985 391619006025 major tail sheath protein; Provisional; Region: FI; PHA02560 391619006026 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684 391619006027 Baseplate J-like protein; Region: Baseplate_J; cl01294 391619006028 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 391619006029 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 391619006030 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; cl05094 391619006031 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 391619006032 Phage capsid family; Region: Phage_capsid; pfam05065 391619006033 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 391619006034 Phage portal protein, lambda family; Region: Phage_portal_2; pfam05136 391619006035 Phage terminase large subunit (GpA); Region: Terminase_GpA; pfam05876 391619006036 Phage DNA packaging protein Nu1; Region: Phage_Nu1; cl01720 391619006037 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391619006038 AAA domain; Region: AAA_23; pfam13476 391619006039 AAA domain; Region: AAA_21; pfam13304 391619006040 Walker A/P-loop; other site 391619006041 ATP binding site [chemical binding]; other site 391619006042 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 391619006043 Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073 391619006044 Helix-turn-helix domain; Region: HTH_36; pfam13730 391619006045 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391619006046 Methyltransferase domain; Region: Methyltransf_26; pfam13659 391619006047 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 391619006048 sequence-specific DNA binding site [nucleotide binding]; other site 391619006049 salt bridge; other site 391619006050 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391619006051 sequence-specific DNA binding site [nucleotide binding]; other site 391619006052 salt bridge; other site 391619006053 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 391619006054 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 391619006055 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 391619006056 active site 391619006057 catalytic residues [active] 391619006058 DNA binding site [nucleotide binding] 391619006059 Int/Topo IB signature motif; other site 391619006060 Uncharacterized conserved protein [Function unknown]; Region: COG0062 391619006061 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 391619006062 putative substrate binding site [chemical binding]; other site 391619006063 putative ATP binding site [chemical binding]; other site 391619006064 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 391619006065 Nitrogen regulatory protein P-II; Region: P-II; smart00938 391619006066 glutamine synthetase; Provisional; Region: glnA; PRK09469 391619006067 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 391619006068 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 391619006069 Protein of unknown function (DUF3445); Region: DUF3445; pfam11927 391619006070 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 391619006071 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 391619006072 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 391619006073 active site 391619006074 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 391619006075 nudix motif; other site 391619006076 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391619006077 Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765 391619006078 adenylosuccinate lyase; Provisional; Region: PRK07492 391619006079 Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360 391619006080 tetramer interface [polypeptide binding]; other site 391619006081 active site 391619006082 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 391619006083 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 391619006084 binding surface 391619006085 TPR motif; other site 391619006086 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391619006087 TPR motif; other site 391619006088 Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536 391619006089 FliG C-terminal domain; Region: FliG_C; pfam01706 391619006090 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 391619006091 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 391619006092 putative acyl-acceptor binding pocket; other site 391619006093 Protein of unknown function (DUF1223); Region: DUF1223; pfam06764 391619006094 aconitate hydratase; Validated; Region: PRK09277 391619006095 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 391619006096 substrate binding site [chemical binding]; other site 391619006097 ligand binding site [chemical binding]; other site 391619006098 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 391619006099 substrate binding site [chemical binding]; other site 391619006100 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 391619006101 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 391619006102 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 391619006103 catalytic residues [active] 391619006104 central insert; other site 391619006105 heme exporter protein CcmC; Region: ccmC; TIGR01191 391619006106 heme exporter protein CcmB; Region: ccmB; TIGR01190 391619006107 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13539 391619006108 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391619006109 Walker A/P-loop; other site 391619006110 ATP binding site [chemical binding]; other site 391619006111 Q-loop/lid; other site 391619006112 ABC transporter signature motif; other site 391619006113 Walker B; other site 391619006114 D-loop; other site 391619006115 H-loop/switch region; other site 391619006116 Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248 391619006117 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 391619006118 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 391619006119 Protein export membrane protein; Region: SecD_SecF; pfam02355 391619006120 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 391619006121 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 391619006122 Preprotein translocase subunit; Region: YajC; pfam02699 391619006123 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 391619006124 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 391619006125 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 391619006126 seryl-tRNA synthetase; Provisional; Region: PRK05431 391619006127 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 391619006128 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 391619006129 dimer interface [polypeptide binding]; other site 391619006130 active site 391619006131 motif 1; other site 391619006132 motif 2; other site 391619006133 motif 3; other site 391619006134 Pathogenicity locus; Region: Cdd1; pfam11731 391619006135 Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239 391619006136 The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507 391619006137 putative di-iron ligands [ion binding]; other site 391619006138 GTP-binding protein Der; Reviewed; Region: PRK00093 391619006139 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 391619006140 G1 box; other site 391619006141 GTP/Mg2+ binding site [chemical binding]; other site 391619006142 Switch I region; other site 391619006143 G2 box; other site 391619006144 Switch II region; other site 391619006145 G3 box; other site 391619006146 G4 box; other site 391619006147 G5 box; other site 391619006148 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 391619006149 G1 box; other site 391619006150 GTP/Mg2+ binding site [chemical binding]; other site 391619006151 Switch I region; other site 391619006152 G2 box; other site 391619006153 G3 box; other site 391619006154 Switch II region; other site 391619006155 G4 box; other site 391619006156 G5 box; other site 391619006157 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 391619006158 Trp docking motif [polypeptide binding]; other site 391619006159 active site 391619006160 PQQ-like domain; Region: PQQ_2; pfam13360 391619006161 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 391619006162 HlyD family secretion protein; Region: HlyD_3; pfam13437 391619006163 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 391619006164 Protein export membrane protein; Region: SecD_SecF; cl14618 391619006165 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 391619006166 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391619006167 ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265 391619006168 ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253 391619006169 Walker A/P-loop; other site 391619006170 ATP binding site [chemical binding]; other site 391619006171 Q-loop/lid; other site 391619006172 ABC transporter signature motif; other site 391619006173 Walker B; other site 391619006174 D-loop; other site 391619006175 H-loop/switch region; other site 391619006176 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 391619006177 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 391619006178 Protein required for attachment to host cells; Region: Host_attach; pfam10116 391619006179 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 391619006180 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 391619006181 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 391619006182 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 391619006183 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 391619006184 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 391619006185 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391619006186 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 391619006187 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 391619006188 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391619006189 Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235 391619006190 cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142 391619006191 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 391619006192 Protein of unknown function (DUF1289); Region: DUF1289; pfam06945 391619006193 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 391619006194 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 391619006195 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 391619006196 FMN binding site [chemical binding]; other site 391619006197 active site 391619006198 catalytic residues [active] 391619006199 substrate binding site [chemical binding]; other site 391619006200 Domain of unknown function (DUF892); Region: DUF892; cl17410 391619006201 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391619006202 active site 391619006203 DNA binding site [nucleotide binding] 391619006204 Int/Topo IB signature motif; other site 391619006205 NACHT domain; Region: NACHT; pfam05729 391619006206 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391619006207 Walker A motif; other site 391619006208 ATP binding site [chemical binding]; other site 391619006209 Walker B motif; other site 391619006210 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 391619006211 ParB-like nuclease domain; Region: ParBc; pfam02195 391619006212 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 391619006213 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391619006214 Walker A motif; other site 391619006215 ATP binding site [chemical binding]; other site 391619006216 Walker B motif; other site 391619006217 arginine finger; other site 391619006218 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391619006219 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 391619006220 DNA binding residues [nucleotide binding] 391619006221 Integrase core domain; Region: rve; pfam00665 391619006222 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 391619006223 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 391619006224 putative catalytic cysteine [active] 391619006225 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 391619006226 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391619006227 PYR/PP interface [polypeptide binding]; other site 391619006228 dimer interface [polypeptide binding]; other site 391619006229 TPP binding site [chemical binding]; other site 391619006230 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 391619006231 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 391619006232 TPP-binding site [chemical binding]; other site 391619006233 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 391619006234 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 391619006235 active site 391619006236 catalytic residues [active] 391619006237 DNA binding site [nucleotide binding] 391619006238 Int/Topo IB signature motif; other site 391619006239 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391619006240 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391619006241 putative DNA binding site [nucleotide binding]; other site 391619006242 putative Zn2+ binding site [ion binding]; other site 391619006243 AsnC family; Region: AsnC_trans_reg; pfam01037 391619006244 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 391619006245 TPP-binding site [chemical binding]; other site 391619006246 PYR/PP interface [polypeptide binding]; other site 391619006247 dimer interface [polypeptide binding]; other site 391619006248 TPP binding site [chemical binding]; other site 391619006249 Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861 391619006250 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 391619006251 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 391619006252 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 391619006253 active site 391619006254 dimer interface [polypeptide binding]; other site 391619006255 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 391619006256 Transcriptional regulators [Transcription]; Region: FadR; COG2186 391619006257 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391619006258 DNA-binding site [nucleotide binding]; DNA binding site 391619006259 FCD domain; Region: FCD; pfam07729 391619006260 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 391619006261 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 391619006262 Walker A/P-loop; other site 391619006263 ATP binding site [chemical binding]; other site 391619006264 Q-loop/lid; other site 391619006265 ABC transporter signature motif; other site 391619006266 Walker B; other site 391619006267 D-loop; other site 391619006268 H-loop/switch region; other site 391619006269 TOBE domain; Region: TOBE_2; pfam08402 391619006270 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391619006271 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619006272 dimer interface [polypeptide binding]; other site 391619006273 conserved gate region; other site 391619006274 putative PBP binding loops; other site 391619006275 ABC-ATPase subunit interface; other site 391619006276 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619006277 dimer interface [polypeptide binding]; other site 391619006278 putative PBP binding loops; other site 391619006279 ABC-ATPase subunit interface; other site 391619006280 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391619006281 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391619006282 hypothetical protein; Provisional; Region: PRK05968 391619006283 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 391619006284 homodimer interface [polypeptide binding]; other site 391619006285 substrate-cofactor binding pocket; other site 391619006286 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391619006287 catalytic residue [active] 391619006288 Uncharacterized conserved protein [Function unknown]; Region: COG3791 391619006289 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 391619006290 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 391619006291 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 391619006292 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 391619006293 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 391619006294 ligand binding site [chemical binding]; other site 391619006295 flexible hinge region; other site 391619006296 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 391619006297 putative switch regulator; other site 391619006298 non-specific DNA interactions [nucleotide binding]; other site 391619006299 DNA binding site [nucleotide binding] 391619006300 sequence specific DNA binding site [nucleotide binding]; other site 391619006301 putative cAMP binding site [chemical binding]; other site 391619006302 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 391619006303 putative active site [active] 391619006304 heme pocket [chemical binding]; other site 391619006305 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391619006306 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391619006307 dimer interface [polypeptide binding]; other site 391619006308 phosphorylation site [posttranslational modification] 391619006309 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391619006310 ATP binding site [chemical binding]; other site 391619006311 Mg2+ binding site [ion binding]; other site 391619006312 G-X-G motif; other site 391619006313 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 391619006314 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391619006315 active site 391619006316 phosphorylation site [posttranslational modification] 391619006317 intermolecular recognition site; other site 391619006318 dimerization interface [polypeptide binding]; other site 391619006319 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086 391619006320 putative binding surface; other site 391619006321 active site 391619006322 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 391619006323 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391619006324 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391619006325 active site 391619006326 phosphorylation site [posttranslational modification] 391619006327 intermolecular recognition site; other site 391619006328 dimerization interface [polypeptide binding]; other site 391619006329 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391619006330 DNA binding residues [nucleotide binding] 391619006331 dimerization interface [polypeptide binding]; other site 391619006332 Protein of unknown function (DUF2474); Region: DUF2474; pfam10617 391619006333 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 391619006334 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 391619006335 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 391619006336 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 391619006337 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 391619006338 ligand binding site [chemical binding]; other site 391619006339 flexible hinge region; other site 391619006340 Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545 391619006341 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 391619006342 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 391619006343 high affinity sulphate transporter 1; Region: sulP; TIGR00815 391619006344 Sulfate transporter family; Region: Sulfate_transp; pfam00916 391619006345 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 391619006346 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479 391619006347 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 391619006348 active site 391619006349 Cupin domain; Region: Cupin_2; cl17218 391619006350 TfoX C-terminal domain; Region: TfoX_C; pfam04994 391619006351 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 391619006352 Domain of unknown function (DUF4112); Region: DUF4112; pfam13430 391619006353 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 391619006354 active site 391619006355 multimer interface [polypeptide binding]; other site 391619006356 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 391619006357 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 391619006358 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 391619006359 ABC transporter; Region: ABC_tran_2; pfam12848 391619006360 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 391619006361 Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095 391619006362 Predicted aspartyl protease [General function prediction only]; Region: COG3577 391619006363 Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483 391619006364 catalytic motif [active] 391619006365 Catalytic residue [active] 391619006366 DNA polymerase III subunit chi; Validated; Region: PRK05728 391619006367 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 391619006368 multifunctional aminopeptidase A; Provisional; Region: PRK00913 391619006369 interface (dimer of trimers) [polypeptide binding]; other site 391619006370 Substrate-binding/catalytic site; other site 391619006371 Zn-binding sites [ion binding]; other site 391619006372 Predicted permeases [General function prediction only]; Region: COG0795 391619006373 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 391619006374 Predicted permeases [General function prediction only]; Region: COG0795 391619006375 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 391619006376 Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452 391619006377 OstA-like protein; Region: OstA; cl00844 391619006378 Organic solvent tolerance protein; Region: OstA_C; pfam04453 391619006379 SurA N-terminal domain; Region: SurA_N; pfam09312 391619006380 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 391619006381 4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312 391619006382 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 391619006383 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 391619006384 Domain of unknown function (DUF4167); Region: DUF4167; pfam13763 391619006385 protein-(glutamine-N5) methyltransferase, release factor-specific; Region: RF_mod_PrmC; TIGR03534 391619006386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391619006387 S-adenosylmethionine binding site [chemical binding]; other site 391619006388 peptide chain release factor 1; Validated; Region: prfA; PRK00591 391619006389 This domain is found in peptide chain release factors; Region: PCRF; smart00937 391619006390 RF-1 domain; Region: RF-1; pfam00472 391619006391 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 391619006392 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 391619006393 agmatinase; Region: agmatinase; TIGR01230 391619006394 oligomer interface [polypeptide binding]; other site 391619006395 putative active site [active] 391619006396 Mn binding site [ion binding]; other site 391619006397 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 391619006398 agmatinase; Region: agmatinase; TIGR01230 391619006399 oligomer interface [polypeptide binding]; other site 391619006400 putative active site [active] 391619006401 Mn binding site [ion binding]; other site 391619006402 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 391619006403 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 391619006404 metal binding site [ion binding]; metal-binding site 391619006405 putative dimer interface [polypeptide binding]; other site 391619006406 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 391619006407 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 391619006408 homodimer interface [polypeptide binding]; other site 391619006409 metal binding site [ion binding]; metal-binding site 391619006410 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 391619006411 homodimer interface [polypeptide binding]; other site 391619006412 active site 391619006413 putative chemical substrate binding site [chemical binding]; other site 391619006414 metal binding site [ion binding]; metal-binding site 391619006415 Peptidase family M48; Region: Peptidase_M48; cl12018 391619006416 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 391619006417 luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558 391619006418 PIN domain; Region: PIN_3; pfam13470 391619006419 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 391619006420 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 391619006421 putative RNA binding site [nucleotide binding]; other site 391619006422 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391619006423 S-adenosylmethionine binding site [chemical binding]; other site 391619006424 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108 391619006425 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 391619006426 metal binding triad; other site 391619006427 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 391619006428 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 391619006429 metal binding triad; other site 391619006430 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 391619006431 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 391619006432 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391619006433 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 391619006434 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391619006435 Walker A motif; other site 391619006436 ATP binding site [chemical binding]; other site 391619006437 Walker B motif; other site 391619006438 arginine finger; other site 391619006439 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391619006440 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 391619006441 DNA binding residues [nucleotide binding] 391619006442 Integrase core domain; Region: rve; pfam00665 391619006443 Phage late control gene D protein (GPD); Region: Phage_GPD; cl15796 391619006444 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 391619006445 Protein of unknown function (DUF2852); Region: DUF2852; pfam11014 391619006446 RDD family; Region: RDD; pfam06271 391619006447 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 391619006448 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 391619006449 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 391619006450 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391619006451 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263 391619006452 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 391619006453 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 391619006454 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 391619006455 TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663 391619006456 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391619006457 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564 391619006458 Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049 391619006459 Histidine kinase; Region: HisKA_3; pfam07730 391619006460 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391619006461 ATP binding site [chemical binding]; other site 391619006462 Mg2+ binding site [ion binding]; other site 391619006463 G-X-G motif; other site 391619006464 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391619006465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391619006466 active site 391619006467 phosphorylation site [posttranslational modification] 391619006468 intermolecular recognition site; other site 391619006469 dimerization interface [polypeptide binding]; other site 391619006470 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391619006471 DNA binding residues [nucleotide binding] 391619006472 dimerization interface [polypeptide binding]; other site 391619006473 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107 391619006474 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391619006475 PYR/PP interface [polypeptide binding]; other site 391619006476 dimer interface [polypeptide binding]; other site 391619006477 TPP binding site [chemical binding]; other site 391619006478 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 391619006479 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 391619006480 TPP-binding site [chemical binding]; other site 391619006481 dimer interface [polypeptide binding]; other site 391619006482 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 391619006483 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 391619006484 putative valine binding site [chemical binding]; other site 391619006485 dimer interface [polypeptide binding]; other site 391619006486 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 391619006487 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391619006488 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391619006489 non-specific DNA binding site [nucleotide binding]; other site 391619006490 sequence-specific DNA binding site [nucleotide binding]; other site 391619006491 salt bridge; other site 391619006492 Predicted integral membrane protein (DUF2189); Region: DUF2189; pfam09955 391619006493 amidase; Provisional; Region: PRK07486 391619006494 Amidase; Region: Amidase; cl11426 391619006495 peptide chain release factor 2; Validated; Region: prfB; PRK00578 391619006496 This domain is found in peptide chain release factors; Region: PCRF; smart00937 391619006497 RF-1 domain; Region: RF-1; pfam00472 391619006498 Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009 391619006499 Transglycosylase; Region: Transgly; pfam00912 391619006500 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 391619006501 AMIN domain; Region: AMIN; pfam11741 391619006502 N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860 391619006503 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 391619006504 active site 391619006505 metal binding site [ion binding]; metal-binding site 391619006506 aspartate aminotransferase; Provisional; Region: PRK05764 391619006507 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391619006508 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391619006509 homodimer interface [polypeptide binding]; other site 391619006510 catalytic residue [active] 391619006511 Peptidase family M48; Region: Peptidase_M48; cl12018 391619006512 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 391619006513 TPR motif; other site 391619006514 TPR repeat; Region: TPR_11; pfam13414 391619006515 binding surface 391619006516 Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651 391619006517 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 391619006518 catalytic residues [active] 391619006519 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 391619006520 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 391619006521 Helix-turn-helix domain; Region: HTH_25; pfam13413 391619006522 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 391619006523 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 391619006524 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 391619006525 substrate-cofactor binding pocket; other site 391619006526 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391619006527 catalytic residue [active] 391619006528 hypothetical protein; Validated; Region: PRK09104 391619006529 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 391619006530 metal binding site [ion binding]; metal-binding site 391619006531 putative dimer interface [polypeptide binding]; other site 391619006532 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 391619006533 catalytic core [active] 391619006534 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391619006535 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391619006536 putative DNA binding site [nucleotide binding]; other site 391619006537 putative Zn2+ binding site [ion binding]; other site 391619006538 AsnC family; Region: AsnC_trans_reg; pfam01037 391619006539 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 391619006540 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 391619006541 NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075 391619006542 NAD binding site [chemical binding]; other site 391619006543 Phe binding site; other site 391619006544 YrhK-like protein; Region: YrhK; pfam14145 391619006545 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 391619006546 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 391619006547 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391619006548 S-adenosylmethionine binding site [chemical binding]; other site 391619006549 Transcriptional regulators [Transcription]; Region: MarR; COG1846 391619006550 MarR family; Region: MarR_2; pfam12802 391619006551 ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466 391619006552 Found in ATP-dependent protease La (LON); Region: LON; smart00464 391619006553 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391619006554 Walker A motif; other site 391619006555 ATP binding site [chemical binding]; other site 391619006556 Walker B motif; other site 391619006557 arginine finger; other site 391619006558 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 391619006559 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 391619006560 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 391619006561 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 391619006562 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 391619006563 Protein of unknown function (DUF1826); Region: DUF1826; pfam08856 391619006564 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 391619006565 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 391619006566 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 391619006567 FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945 391619006568 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 391619006569 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 391619006570 active site 391619006571 catalytic site [active] 391619006572 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 391619006573 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 391619006574 triosephosphate isomerase; Provisional; Region: PRK14565 391619006575 substrate binding site [chemical binding]; other site 391619006576 dimer interface [polypeptide binding]; other site 391619006577 catalytic triad [active] 391619006578 DctM-like transporters; Region: DctM; pfam06808 391619006579 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 391619006580 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 391619006581 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 391619006582 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 391619006583 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 391619006584 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391619006585 active site 391619006586 phosphorylation site [posttranslational modification] 391619006587 intermolecular recognition site; other site 391619006588 dimerization interface [polypeptide binding]; other site 391619006589 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 391619006590 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 391619006591 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 391619006592 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391619006593 dimer interface [polypeptide binding]; other site 391619006594 phosphorylation site [posttranslational modification] 391619006595 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391619006596 ATP binding site [chemical binding]; other site 391619006597 Mg2+ binding site [ion binding]; other site 391619006598 G-X-G motif; other site 391619006599 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 391619006600 Cytochrome P450; Region: p450; cl12078 391619006601 sugar efflux transporter; Region: 2A0120; TIGR00899 391619006602 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391619006603 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391619006604 putative DNA binding site [nucleotide binding]; other site 391619006605 putative Zn2+ binding site [ion binding]; other site 391619006606 AsnC family; Region: AsnC_trans_reg; pfam01037 391619006607 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 391619006608 active site 391619006609 SAM binding site [chemical binding]; other site 391619006610 homodimer interface [polypeptide binding]; other site 391619006611 Protein of unknown function (DUF2849); Region: DUF2849; pfam11011 391619006612 Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155 391619006613 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 391619006614 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 391619006615 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 391619006616 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 391619006617 Active Sites [active] 391619006618 Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526 391619006619 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 391619006620 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 391619006621 FAD binding pocket [chemical binding]; other site 391619006622 FAD binding motif [chemical binding]; other site 391619006623 phosphate binding motif [ion binding]; other site 391619006624 beta-alpha-beta structure motif; other site 391619006625 NAD binding pocket [chemical binding]; other site 391619006626 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391619006627 YodA lipocalin-like domain; Region: YodA; cl01365 391619006628 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 391619006629 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 391619006630 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 391619006631 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 391619006632 putative CheW interface [polypeptide binding]; other site 391619006633 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 391619006634 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 391619006635 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 391619006636 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 391619006637 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 391619006638 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 391619006639 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159 391619006640 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 391619006641 MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522 391619006642 putative MPT binding site; other site 391619006643 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 391619006644 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 391619006645 XdhC Rossmann domain; Region: XdhC_C; pfam13478 391619006646 polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848 391619006647 PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879 391619006648 PHB accumulation regulatory domain; Region: PHB_acc; pfam05233 391619006649 carbamoyl-phosphate synthase (glutamine-hydrolyzing); Region: PLN02771 391619006650 poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838 391619006651 Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167 391619006652 polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849 391619006653 PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850 391619006654 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391619006655 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 391619006656 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 391619006657 Switch II region; other site 391619006658 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 391619006659 G4 box; other site 391619006660 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 391619006661 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 391619006662 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 391619006663 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 391619006664 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 391619006665 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 391619006666 active site 391619006667 dimer interface [polypeptide binding]; other site 391619006668 motif 1; other site 391619006669 motif 2; other site 391619006670 motif 3; other site 391619006671 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 391619006672 anticodon binding site; other site 391619006673 Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048 391619006674 hypothetical protein; Provisional; Region: PRK05409 391619006675 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 391619006676 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 391619006677 ArsC family; Region: ArsC; pfam03960 391619006678 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 391619006679 DNA-binding site [nucleotide binding]; DNA binding site 391619006680 RNA-binding motif; other site 391619006681 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391619006682 Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114 391619006683 NAD(P) binding site [chemical binding]; other site 391619006684 catalytic residues [active] 391619006685 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 391619006686 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 391619006687 Flavin reductase like domain; Region: Flavin_Reduct; smart00903 391619006688 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 391619006689 nudix motif; other site 391619006690 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391619006691 Amino acid synthesis; Region: AA_synth; pfam06684 391619006692 Transcriptional regulators [Transcription]; Region: GntR; COG1802 391619006693 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391619006694 DNA-binding site [nucleotide binding]; DNA binding site 391619006695 FCD domain; Region: FCD; pfam07729 391619006696 Uncharacterized conserved protein [Function unknown]; Region: COG5470 391619006697 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 391619006698 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 391619006699 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 391619006700 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 391619006701 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 391619006702 active site 391619006703 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 391619006704 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 391619006705 folate binding site [chemical binding]; other site 391619006706 NADP+ binding site [chemical binding]; other site 391619006707 thymidylate synthase; Reviewed; Region: thyA; PRK01827 391619006708 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 391619006709 dimerization interface [polypeptide binding]; other site 391619006710 active site 391619006711 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 391619006712 dimer interface [polypeptide binding]; other site 391619006713 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391619006714 active site 391619006715 metal binding site [ion binding]; metal-binding site 391619006716 glutathione binding site [chemical binding]; other site 391619006717 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 391619006718 Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937 391619006719 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391619006720 sequence-specific DNA binding site [nucleotide binding]; other site 391619006721 salt bridge; other site 391619006722 aspartate aminotransferase; Provisional; Region: PRK05764 391619006723 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391619006724 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391619006725 homodimer interface [polypeptide binding]; other site 391619006726 catalytic residue [active] 391619006727 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391619006728 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391619006729 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391619006730 dimerization interface [polypeptide binding]; other site 391619006731 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 391619006732 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184 391619006733 active site 391619006734 iron coordination sites [ion binding]; other site 391619006735 substrate binding pocket [chemical binding]; other site 391619006736 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 391619006737 Sulfatase; Region: Sulfatase; pfam00884 391619006738 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 391619006739 putative efflux protein, MATE family; Region: matE; TIGR00797 391619006740 cation binding site [ion binding]; other site 391619006741 Conserved hypothetical protein (DUF2461); Region: DUF2461; cl02374 391619006742 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 391619006743 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 391619006744 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391619006745 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391619006746 catalytic residue [active] 391619006747 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 391619006748 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391619006749 Mg2+ binding site [ion binding]; other site 391619006750 G-X-G motif; other site 391619006751 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 391619006752 anchoring element; other site 391619006753 dimer interface [polypeptide binding]; other site 391619006754 ATP binding site [chemical binding]; other site 391619006755 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 391619006756 active site 391619006757 metal binding site [ion binding]; metal-binding site 391619006758 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 391619006759 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 391619006760 The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766 391619006761 putative [4Fe-4S] binding site [ion binding]; other site 391619006762 putative molybdopterin cofactor binding site [chemical binding]; other site 391619006763 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 391619006764 molybdopterin cofactor binding site; other site 391619006765 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 391619006766 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 391619006767 Walker A/P-loop; other site 391619006768 ATP binding site [chemical binding]; other site 391619006769 Q-loop/lid; other site 391619006770 ABC transporter signature motif; other site 391619006771 Walker B; other site 391619006772 D-loop; other site 391619006773 H-loop/switch region; other site 391619006774 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 391619006775 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 391619006776 FtsX-like permease family; Region: FtsX; pfam02687 391619006777 prolyl-tRNA synthetase; Provisional; Region: PRK12325 391619006778 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 391619006779 dimer interface [polypeptide binding]; other site 391619006780 motif 1; other site 391619006781 active site 391619006782 motif 2; other site 391619006783 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 391619006784 active site 391619006785 motif 3; other site 391619006786 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 391619006787 anticodon binding site; other site 391619006788 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 391619006789 Domain of unknown function DUF20; Region: UPF0118; pfam01594 391619006790 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 391619006791 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 391619006792 exopolyphosphatase; Region: exo_poly_only; TIGR03706 391619006793 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 391619006794 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 391619006795 putative catalytic site [active] 391619006796 putative metal binding site [ion binding]; other site 391619006797 putative phosphate binding site [ion binding]; other site 391619006798 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 391619006799 DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076 391619006800 putative metal binding site [ion binding]; other site 391619006801 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 391619006802 HSP70 interaction site [polypeptide binding]; other site 391619006803 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 391619006804 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 391619006805 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 391619006806 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 391619006807 active site 391619006808 substrate binding site [chemical binding]; other site 391619006809 coenzyme B12 binding site [chemical binding]; other site 391619006810 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 391619006811 B12 binding site [chemical binding]; other site 391619006812 cobalt ligand [ion binding]; other site 391619006813 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 391619006814 Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770 391619006815 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391619006816 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 391619006817 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 391619006818 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 391619006819 carboxyltransferase (CT) interaction site; other site 391619006820 biotinylation site [posttranslational modification]; other site 391619006821 Src Homology 3 domain superfamily; Region: SH3; cl17036 391619006822 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 391619006823 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 391619006824 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 391619006825 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 391619006826 active site 391619006827 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 391619006828 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391619006829 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 391619006830 putative substrate translocation pore; other site 391619006831 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391619006832 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391619006833 non-specific DNA binding site [nucleotide binding]; other site 391619006834 salt bridge; other site 391619006835 sequence-specific DNA binding site [nucleotide binding]; other site 391619006836 Predicted transcriptional regulator [General function prediction only]; Region: COG3800 391619006837 Domain of unknown function (DUF955); Region: DUF955; pfam06114 391619006838 Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856 391619006839 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841 391619006840 choline dehydrogenase; Validated; Region: PRK02106 391619006841 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391619006842 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 391619006843 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 391619006844 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 391619006845 NAD(P) binding site [chemical binding]; other site 391619006846 catalytic residues [active] 391619006847 Sulfatase; Region: Sulfatase; cl17466 391619006848 choline-sulfatase; Region: chol_sulfatase; TIGR03417 391619006849 Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411 391619006850 BCCT family transporter; Region: BCCT; cl00569 391619006851 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 391619006852 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 391619006853 Protein of unknown function (DUF1036); Region: DUF1036; cl02296 391619006854 Lysine efflux permease [General function prediction only]; Region: COG1279 391619006855 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 391619006856 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391619006857 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391619006858 dimerization interface [polypeptide binding]; other site 391619006859 Predicted periplasmic protein [Function unknown]; Region: COG3904 391619006860 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 391619006861 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391619006862 Coenzyme A binding pocket [chemical binding]; other site 391619006863 hypothetical protein; Validated; Region: PRK00110 391619006864 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 391619006865 transmembrane helices; other site 391619006866 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 391619006867 TrkA-C domain; Region: TrkA_C; pfam02080 391619006868 TrkA-C domain; Region: TrkA_C; pfam02080 391619006869 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 391619006870 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 391619006871 FAD binding domain; Region: FAD_binding_2; pfam00890 391619006872 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 391619006873 transmembrane helices; other site 391619006874 TrkA-C domain; Region: TrkA_C; pfam02080 391619006875 TrkA-C domain; Region: TrkA_C; pfam02080 391619006876 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 391619006877 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 391619006878 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 391619006879 Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854 391619006880 putative active site [active] 391619006881 metal binding site [ion binding]; metal-binding site 391619006882 homodimer binding site [polypeptide binding]; other site 391619006883 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 391619006884 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 391619006885 MgtE intracellular N domain; Region: MgtE_N; smart00924 391619006886 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 391619006887 Divalent cation transporter; Region: MgtE; pfam01769 391619006888 guanine deaminase; Provisional; Region: PRK09228 391619006889 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 391619006890 active site 391619006891 hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203 391619006892 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 391619006893 active site 391619006894 putative substrate binding pocket [chemical binding]; other site 391619006895 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 391619006896 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 391619006897 active site 391619006898 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391619006899 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391619006900 non-specific DNA binding site [nucleotide binding]; other site 391619006901 salt bridge; other site 391619006902 sequence-specific DNA binding site [nucleotide binding]; other site 391619006903 Quinone oxidoreductase (QOR); Region: QOR1; cd08241 391619006904 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 391619006905 NAD(P) binding site [chemical binding]; other site 391619006906 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391619006907 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391619006908 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 391619006909 dimerization interface [polypeptide binding]; other site 391619006910 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 391619006911 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 391619006912 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 391619006913 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 391619006914 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391619006915 Coenzyme A binding pocket [chemical binding]; other site 391619006916 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 391619006917 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 391619006918 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 391619006919 amidase catalytic site [active] 391619006920 Zn binding residues [ion binding]; other site 391619006921 substrate binding site [chemical binding]; other site 391619006922 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 391619006923 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 391619006924 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 391619006925 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 391619006926 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 391619006927 Methyladenine glycosylase; Region: Adenine_glyco; pfam03352 391619006928 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 391619006929 nucleoside/Zn binding site; other site 391619006930 dimer interface [polypeptide binding]; other site 391619006931 catalytic motif [active] 391619006932 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 391619006933 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 391619006934 RNA binding surface [nucleotide binding]; other site 391619006935 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 391619006936 active site 391619006937 5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059 391619006938 Toxic anion resistance protein (TelA); Region: TelA; pfam05816 391619006939 Protein of unknown function (DUF2927); Region: DUF2927; pfam11150 391619006940 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 391619006941 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 391619006942 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 391619006943 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 391619006944 Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136 391619006945 putative FMN binding site [chemical binding]; other site 391619006946 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 391619006947 putative active site [active] 391619006948 dimerization interface [polypeptide binding]; other site 391619006949 putative tRNAtyr binding site [nucleotide binding]; other site 391619006950 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391619006951 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 391619006952 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391619006953 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619006954 dimer interface [polypeptide binding]; other site 391619006955 conserved gate region; other site 391619006956 ABC-ATPase subunit interface; other site 391619006957 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 391619006958 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 391619006959 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619006960 dimer interface [polypeptide binding]; other site 391619006961 conserved gate region; other site 391619006962 ABC-ATPase subunit interface; other site 391619006963 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 391619006964 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391619006965 Walker A/P-loop; other site 391619006966 ATP binding site [chemical binding]; other site 391619006967 Q-loop/lid; other site 391619006968 ABC transporter signature motif; other site 391619006969 Walker B; other site 391619006970 D-loop; other site 391619006971 H-loop/switch region; other site 391619006972 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391619006973 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391619006974 Walker A/P-loop; other site 391619006975 ATP binding site [chemical binding]; other site 391619006976 Q-loop/lid; other site 391619006977 ABC transporter signature motif; other site 391619006978 Walker B; other site 391619006979 D-loop; other site 391619006980 H-loop/switch region; other site 391619006981 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391619006982 Uncharacterized conserved protein [Function unknown]; Region: COG3379 391619006983 Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524 391619006984 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 391619006985 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 391619006986 substrate binding pocket [chemical binding]; other site 391619006987 AMP-binding domain protein; Validated; Region: PRK07529 391619006988 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391619006989 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944 391619006990 acyl-activating enzyme (AAE) consensus motif; other site 391619006991 putative AMP binding site [chemical binding]; other site 391619006992 putative active site [active] 391619006993 putative CoA binding site [chemical binding]; other site 391619006994 ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204 391619006995 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391619006996 ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249 391619006997 Walker A/P-loop; other site 391619006998 ATP binding site [chemical binding]; other site 391619006999 Q-loop/lid; other site 391619007000 ABC transporter signature motif; other site 391619007001 Walker B; other site 391619007002 D-loop; other site 391619007003 H-loop/switch region; other site 391619007004 Uncharacterized ACR, COG2135; Region: DUF159; pfam02586 391619007005 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 391619007006 SIR2 superfamily of proteins includes silent information regulator 2 (Sir2) enzymes which catalyze NAD+-dependent protein/histone deacetylation, where the acetyl group from the lysine epsilon-amino group is transferred to the ADP-ribose moiety of NAD+; Region: SIR2; cl00195 391619007007 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 391619007008 Protein of unknown function (DUF1353); Region: DUF1353; pfam07087 391619007009 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 391619007010 Bacteriophage protein of unknown function (DUF646); Region: DUF646; pfam04883 391619007011 Phage head-tail joining protein; Region: Phage_H_T_join; cl11461 391619007012 phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215 391619007013 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 391619007014 oligomerization interface [polypeptide binding]; other site 391619007015 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 391619007016 Phage capsid family; Region: Phage_capsid; pfam05065 391619007017 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 391619007018 Phage-related protein [Function unknown]; Region: COG4695 391619007019 Phage portal protein; Region: Phage_portal; pfam04860 391619007020 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 391619007021 Helix-turn-helix domain; Region: HTH_19; pfam12844 391619007022 non-specific DNA binding site [nucleotide binding]; other site 391619007023 salt bridge; other site 391619007024 sequence-specific DNA binding site [nucleotide binding]; other site 391619007025 DNA polymerase III subunit beta; Validated; Region: PRK05643 391619007026 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 391619007027 putative DNA binding surface [nucleotide binding]; other site 391619007028 dimer interface [polypeptide binding]; other site 391619007029 beta-clamp/clamp loader binding surface; other site 391619007030 beta-clamp/translesion DNA polymerase binding surface; other site 391619007031 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 391619007032 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 391619007033 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 391619007034 cofactor binding site; other site 391619007035 DNA binding site [nucleotide binding] 391619007036 substrate interaction site [chemical binding]; other site 391619007037 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 391619007038 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391619007039 active site 391619007040 DNA binding site [nucleotide binding] 391619007041 Int/Topo IB signature motif; other site 391619007042 Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018 391619007043 putative hydrophobic ligand binding site [chemical binding]; other site 391619007044 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391619007045 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391619007046 active site 391619007047 phosphorylation site [posttranslational modification] 391619007048 intermolecular recognition site; other site 391619007049 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391619007050 DNA binding residues [nucleotide binding] 391619007051 dimerization interface [polypeptide binding]; other site 391619007052 Uncharacterized conserved protein [Function unknown]; Region: COG3287 391619007053 FIST N domain; Region: FIST; pfam08495 391619007054 FIST C domain; Region: FIST_C; pfam10442 391619007055 PAS fold; Region: PAS_7; pfam12860 391619007056 PAS fold; Region: PAS_7; pfam12860 391619007057 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391619007058 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391619007059 dimer interface [polypeptide binding]; other site 391619007060 phosphorylation site [posttranslational modification] 391619007061 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391619007062 ATP binding site [chemical binding]; other site 391619007063 Mg2+ binding site [ion binding]; other site 391619007064 G-X-G motif; other site 391619007065 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391619007066 active site 391619007067 phosphorylation site [posttranslational modification] 391619007068 intermolecular recognition site; other site 391619007069 dimerization interface [polypeptide binding]; other site 391619007070 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 391619007071 putative active site [active] 391619007072 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 391619007073 putative active site [active] 391619007074 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 391619007075 active site 391619007076 catalytic residues [active] 391619007077 DNA binding site [nucleotide binding] 391619007078 Int/Topo IB signature motif; other site 391619007079 Mnt; Region: mnt; PHA01513 391619007080 Arc-like DNA binding domain; Region: Arc; pfam03869 391619007081 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391619007082 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391619007083 active site 391619007084 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 391619007085 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 391619007086 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391619007087 acetyl-CoA acetyltransferase; Provisional; Region: PRK07108 391619007088 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 391619007089 dimer interface [polypeptide binding]; other site 391619007090 active site 391619007091 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391619007092 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 391619007093 substrate binding site [chemical binding]; other site 391619007094 oxyanion hole (OAH) forming residues; other site 391619007095 trimer interface [polypeptide binding]; other site 391619007096 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 391619007097 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 391619007098 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 391619007099 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK06187 391619007100 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391619007101 acyl-activating enzyme (AAE) consensus motif; other site 391619007102 AMP binding site [chemical binding]; other site 391619007103 active site 391619007104 CoA binding site [chemical binding]; other site 391619007105 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 391619007106 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391619007107 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 391619007108 dimerization interface [polypeptide binding]; other site 391619007109 substrate binding pocket [chemical binding]; other site 391619007110 ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175 391619007111 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391619007112 Walker A/P-loop; other site 391619007113 ATP binding site [chemical binding]; other site 391619007114 Q-loop/lid; other site 391619007115 ABC transporter signature motif; other site 391619007116 Walker B; other site 391619007117 D-loop; other site 391619007118 H-loop/switch region; other site 391619007119 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619007120 dimer interface [polypeptide binding]; other site 391619007121 conserved gate region; other site 391619007122 putative PBP binding loops; other site 391619007123 ABC-ATPase subunit interface; other site 391619007124 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 391619007125 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 391619007126 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 391619007127 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391619007128 catalytic residue [active] 391619007129 TrbC/VIRB2 family; Region: TrbC; pfam04956 391619007130 type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929 391619007131 CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135 391619007132 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 391619007133 Walker A motif; other site 391619007134 ATP binding site [chemical binding]; other site 391619007135 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 391619007136 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 391619007137 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391619007138 catalytic residue [active] 391619007139 VirB8 protein; Region: VirB8; pfam04335 391619007140 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423 391619007141 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 391619007142 VirB7 interaction site; other site 391619007143 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 391619007144 P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788 391619007145 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 391619007146 Walker A motif; other site 391619007147 hexamer interface [polypeptide binding]; other site 391619007148 ATP binding site [chemical binding]; other site 391619007149 Walker B motif; other site 391619007150 Domain of unknown function (DUF4177); Region: DUF4177; pfam13783 391619007151 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 391619007152 Prokaryotic E2 family B; Region: Prok-E2_B; pfam14461 391619007153 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 391619007154 ThiF family; Region: ThiF; pfam00899 391619007155 ATP binding site [chemical binding]; other site 391619007156 substrate interface [chemical binding]; other site 391619007157 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 391619007158 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 391619007159 Walker A motif; other site 391619007160 ATP binding site [chemical binding]; other site 391619007161 Walker B motif; other site 391619007162 type IV secretion system T-DNA border endonuclease VirD2; Provisional; Region: PRK13863 391619007163 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 391619007164 DNA-binding interface [nucleotide binding]; DNA binding site 391619007165 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 391619007166 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 391619007167 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 391619007168 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 391619007169 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 391619007170 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 391619007171 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 391619007172 Walker A/P-loop; other site 391619007173 ATP binding site [chemical binding]; other site 391619007174 Q-loop/lid; other site 391619007175 ABC transporter signature motif; other site 391619007176 Walker B; other site 391619007177 D-loop; other site 391619007178 H-loop/switch region; other site 391619007179 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 391619007180 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391619007181 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391619007182 TM-ABC transporter signature motif; other site 391619007183 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391619007184 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391619007185 TM-ABC transporter signature motif; other site 391619007186 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391619007187 acetoin reductases; Region: 23BDH; TIGR02415 391619007188 NAD(P) binding site [chemical binding]; other site 391619007189 active site 391619007190 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_8; cd06317 391619007191 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 391619007192 putative ligand binding site [chemical binding]; other site 391619007193 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391619007194 sorbitol dehydrogenase; Provisional; Region: PRK07067 391619007195 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391619007196 NAD(P) binding site [chemical binding]; other site 391619007197 active site 391619007198 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 391619007199 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 391619007200 active site 391619007201 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 391619007202 tetramer interface [polypeptide binding]; other site 391619007203 TPP-binding site [chemical binding]; other site 391619007204 heterodimer interface [polypeptide binding]; other site 391619007205 phosphorylation loop region [posttranslational modification] 391619007206 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 391619007207 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 391619007208 alpha subunit interface [polypeptide binding]; other site 391619007209 TPP binding site [chemical binding]; other site 391619007210 heterodimer interface [polypeptide binding]; other site 391619007211 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 391619007212 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 391619007213 E3 interaction surface; other site 391619007214 lipoyl attachment site [posttranslational modification]; other site 391619007215 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 391619007216 E3 interaction surface; other site 391619007217 lipoyl attachment site [posttranslational modification]; other site 391619007218 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391619007219 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 391619007220 tetramerization interface [polypeptide binding]; other site 391619007221 NAD(P) binding site [chemical binding]; other site 391619007222 catalytic residues [active] 391619007223 e3 binding domain; Region: E3_binding; pfam02817 391619007224 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 391619007225 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 391619007226 putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834 391619007227 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 391619007228 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391619007229 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 391619007230 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391619007231 Transposase; Region: DEDD_Tnp_IS110; pfam01548 391619007232 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391619007233 HipA N-terminal domain; Region: Couple_hipA; pfam13657 391619007234 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 391619007235 HipA-like N-terminal domain; Region: HipA_N; pfam07805 391619007236 HipA-like C-terminal domain; Region: HipA_C; pfam07804 391619007237 HipA-like C-terminal domain; Region: HipA_C; pfam07804 391619007238 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 391619007239 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 391619007240 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 391619007241 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 391619007242 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 391619007243 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 391619007244 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 391619007245 Walker A/P-loop; other site 391619007246 ATP binding site [chemical binding]; other site 391619007247 Q-loop/lid; other site 391619007248 ABC transporter signature motif; other site 391619007249 Walker B; other site 391619007250 D-loop; other site 391619007251 H-loop/switch region; other site 391619007252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619007253 dimer interface [polypeptide binding]; other site 391619007254 conserved gate region; other site 391619007255 putative PBP binding loops; other site 391619007256 ABC-ATPase subunit interface; other site 391619007257 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619007258 dimer interface [polypeptide binding]; other site 391619007259 conserved gate region; other site 391619007260 putative PBP binding loops; other site 391619007261 ABC-ATPase subunit interface; other site 391619007262 Phosphotransferase enzyme family; Region: APH; pfam01636 391619007263 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 391619007264 active site 391619007265 ATP binding site [chemical binding]; other site 391619007266 substrate binding site [chemical binding]; other site 391619007267 dimer interface [polypeptide binding]; other site 391619007268 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391619007269 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391619007270 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 391619007271 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 391619007272 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391619007273 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 391619007274 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 391619007275 conserved cys residue [active] 391619007276 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 391619007277 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 391619007278 active site 391619007279 N-formylglutamate amidohydrolase; Region: FGase; cl01522 391619007280 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 391619007281 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 391619007282 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 391619007283 Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102 391619007284 NAD(P) binding site [chemical binding]; other site 391619007285 catalytic residues [active] 391619007286 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 391619007287 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 391619007288 putative active site [active] 391619007289 metal binding site [ion binding]; metal-binding site 391619007290 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 391619007291 Choline Kinase (ChoK). The ChoK subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs), RIO kinases, actin-fragmin kinase (AFK), and...; Region: ChoK; cd05151 391619007292 active site 391619007293 ATP binding site [chemical binding]; other site 391619007294 Phosphotransferase enzyme family; Region: APH; pfam01636 391619007295 substrate binding site [chemical binding]; other site 391619007296 dimer interface [polypeptide binding]; other site 391619007297 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391619007298 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391619007299 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 391619007300 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 391619007301 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391619007302 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 391619007303 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 391619007304 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 391619007305 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 391619007306 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 391619007307 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391619007308 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 391619007309 acyl-activating enzyme (AAE) consensus motif; other site 391619007310 AMP binding site [chemical binding]; other site 391619007311 active site 391619007312 CoA binding site [chemical binding]; other site 391619007313 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391619007314 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391619007315 active site 391619007316 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 391619007317 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391619007318 substrate binding site [chemical binding]; other site 391619007319 oxyanion hole (OAH) forming residues; other site 391619007320 trimer interface [polypeptide binding]; other site 391619007321 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 391619007322 MarR family; Region: MarR; pfam01047 391619007323 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391619007324 classical (c) SDRs; Region: SDR_c; cd05233 391619007325 NAD(P) binding site [chemical binding]; other site 391619007326 active site 391619007327 salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255 391619007328 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 391619007329 active site 391619007330 FMN binding site [chemical binding]; other site 391619007331 substrate binding site [chemical binding]; other site 391619007332 homotetramer interface [polypeptide binding]; other site 391619007333 catalytic residue [active] 391619007334 Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605 391619007335 GAF domain; Region: GAF; pfam01590 391619007336 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 391619007337 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 391619007338 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 391619007339 aspartate kinase; Reviewed; Region: PRK06635 391619007340 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 391619007341 putative nucleotide binding site [chemical binding]; other site 391619007342 putative catalytic residues [active] 391619007343 putative Mg ion binding site [ion binding]; other site 391619007344 putative aspartate binding site [chemical binding]; other site 391619007345 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 391619007346 putative allosteric regulatory site; other site 391619007347 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 391619007348 putative allosteric regulatory residue; other site 391619007349 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 391619007350 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 391619007351 putative GTP cyclohydrolase; Provisional; Region: PRK13674 391619007352 O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504 391619007353 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 391619007354 homodimer interface [polypeptide binding]; other site 391619007355 substrate-cofactor binding pocket; other site 391619007356 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391619007357 catalytic residue [active] 391619007358 Intracellular septation protein A; Region: IspA; pfam04279 391619007359 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 391619007360 EamA-like transporter family; Region: EamA; pfam00892 391619007361 signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064 391619007362 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 391619007363 P loop; other site 391619007364 GTP binding site [chemical binding]; other site 391619007365 YhhN-like protein; Region: YhhN; cl01505 391619007366 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 391619007367 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 391619007368 generic binding surface II; other site 391619007369 generic binding surface I; other site 391619007370 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 391619007371 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 391619007372 ATP-grasp domain; Region: ATP-grasp_4; cl17255 391619007373 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 391619007374 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062 391619007375 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 391619007376 PAS domain; Region: PAS_9; pfam13426 391619007377 putative active site [active] 391619007378 heme pocket [chemical binding]; other site 391619007379 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 391619007380 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 391619007381 DNA binding residues [nucleotide binding] 391619007382 dimerization interface [polypeptide binding]; other site 391619007383 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 391619007384 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 391619007385 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 391619007386 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 391619007387 Protein of unknown function (DUF1217); Region: DUF1217; pfam06748 391619007388 Family description; Region: VCBS; pfam13517 391619007389 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 391619007390 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391619007391 catalytic loop [active] 391619007392 iron binding site [ion binding]; other site 391619007393 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 391619007394 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 391619007395 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 391619007396 ligand binding site [chemical binding]; other site 391619007397 flexible hinge region; other site 391619007398 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 391619007399 putative switch regulator; other site 391619007400 non-specific DNA interactions [nucleotide binding]; other site 391619007401 DNA binding site [nucleotide binding] 391619007402 sequence specific DNA binding site [nucleotide binding]; other site 391619007403 putative cAMP binding site [chemical binding]; other site 391619007404 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 391619007405 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 391619007406 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 391619007407 protein binding site [polypeptide binding]; other site 391619007408 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 391619007409 protein binding site [polypeptide binding]; other site 391619007410 FtsH protease regulator HflC; Provisional; Region: PRK11029 391619007411 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 391619007412 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 391619007413 HflK protein; Region: hflK; TIGR01933 391619007414 glutathione reductase; Validated; Region: PRK06116 391619007415 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391619007416 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391619007417 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 391619007418 AAA domain; Region: AAA_33; pfam13671 391619007419 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 391619007420 active site 391619007421 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 391619007422 tetramer (dimer of dimers) interface [polypeptide binding]; other site 391619007423 active site 391619007424 dimer interface [polypeptide binding]; other site 391619007425 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 391619007426 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 391619007427 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 391619007428 C-terminal domain interface [polypeptide binding]; other site 391619007429 GSH binding site (G-site) [chemical binding]; other site 391619007430 dimer interface [polypeptide binding]; other site 391619007431 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 391619007432 N-terminal domain interface [polypeptide binding]; other site 391619007433 dimer interface [polypeptide binding]; other site 391619007434 substrate binding pocket (H-site) [chemical binding]; other site 391619007435 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 391619007436 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 391619007437 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 391619007438 EamA-like transporter family; Region: EamA; pfam00892 391619007439 Thiamine pyrophosphokinase; Region: TPK; cd07995 391619007440 active site 391619007441 thiamine binding site [chemical binding]; other site 391619007442 dimerization interface [polypeptide binding]; other site 391619007443 Protein of unknown function (DUF2842); Region: DUF2842; pfam11003 391619007444 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 391619007445 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 391619007446 GDP-binding site [chemical binding]; other site 391619007447 ACT binding site; other site 391619007448 IMP binding site; other site 391619007449 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 391619007450 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 391619007451 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 391619007452 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391619007453 Walker A motif; other site 391619007454 ATP binding site [chemical binding]; other site 391619007455 Walker B motif; other site 391619007456 arginine finger; other site 391619007457 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391619007458 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 391619007459 DNA binding residues [nucleotide binding] 391619007460 Integrase core domain; Region: rve; pfam00665 391619007461 nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889 391619007462 Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211 391619007463 nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888 391619007464 Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979 391619007465 NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793 391619007466 CTP synthetase; Validated; Region: pyrG; PRK05380 391619007467 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 391619007468 Catalytic site [active] 391619007469 active site 391619007470 UTP binding site [chemical binding]; other site 391619007471 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 391619007472 active site 391619007473 putative oxyanion hole; other site 391619007474 catalytic triad [active] 391619007475 fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377 391619007476 catalytic residue [active] 391619007477 enoyl-CoA hydratase; Provisional; Region: PRK07509 391619007478 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391619007479 substrate binding site [chemical binding]; other site 391619007480 oxyanion hole (OAH) forming residues; other site 391619007481 trimer interface [polypeptide binding]; other site 391619007482 histidinol-phosphate aminotransferase; Provisional; Region: PRK08153 391619007483 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391619007484 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391619007485 homodimer interface [polypeptide binding]; other site 391619007486 catalytic residue [active] 391619007487 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391619007488 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391619007489 catalytic residue [active] 391619007490 cell division protein DamX; Validated; Region: PRK10905 391619007491 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 391619007492 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391619007493 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391619007494 Walker A/P-loop; other site 391619007495 ATP binding site [chemical binding]; other site 391619007496 Q-loop/lid; other site 391619007497 ABC transporter signature motif; other site 391619007498 Walker B; other site 391619007499 D-loop; other site 391619007500 H-loop/switch region; other site 391619007501 Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571 391619007502 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 391619007503 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391619007504 elongation factor P; Validated; Region: PRK00529 391619007505 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 391619007506 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 391619007507 RNA binding site [nucleotide binding]; other site 391619007508 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 391619007509 RNA binding site [nucleotide binding]; other site 391619007510 cobyric acid synthase; Provisional; Region: PRK00784 391619007511 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 391619007512 Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750 391619007513 catalytic triad [active] 391619007514 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 391619007515 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 391619007516 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391619007517 S-adenosylmethionine binding site [chemical binding]; other site 391619007518 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; smart00782 391619007519 Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824 391619007520 PhnA protein; Region: PhnA; pfam03831 391619007521 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 391619007522 Entericidin EcnA/B family; Region: Entericidin; cl02322 391619007523 Protein of unknown function (DUF3800); Region: DUF3800; pfam12686 391619007524 GTP-binding protein LepA; Provisional; Region: PRK05433 391619007525 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 391619007526 G1 box; other site 391619007527 putative GEF interaction site [polypeptide binding]; other site 391619007528 GTP/Mg2+ binding site [chemical binding]; other site 391619007529 Switch I region; other site 391619007530 G2 box; other site 391619007531 G3 box; other site 391619007532 Switch II region; other site 391619007533 G4 box; other site 391619007534 G5 box; other site 391619007535 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 391619007536 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 391619007537 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 391619007538 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391619007539 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391619007540 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 391619007541 dimerization interface [polypeptide binding]; other site 391619007542 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 391619007543 Low molecular weight phosphatase family; Region: LMWPc; cd00115 391619007544 active site 391619007545 Protein of unknown function (DUF461); Region: DUF461; pfam04314 391619007546 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 391619007547 membrane ATPase/protein kinase; Provisional; Region: PRK09435 391619007548 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 391619007549 Walker A; other site 391619007550 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 391619007551 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391619007552 ATP binding site [chemical binding]; other site 391619007553 putative Mg++ binding site [ion binding]; other site 391619007554 helicase superfamily c-terminal domain; Region: HELICc; smart00490 391619007555 Helicase associated domain (HA2); Region: HA2; pfam04408 391619007556 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 391619007557 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666 391619007558 nudix motif; other site 391619007559 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 391619007560 Phosphate transporter family; Region: PHO4; pfam01384 391619007561 ornithine carbamoyltransferase; Provisional; Region: PRK00779 391619007562 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 391619007563 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 391619007564 acetylornithine transaminase protein; Provisional; Region: argD; PRK01278 391619007565 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 391619007566 inhibitor-cofactor binding pocket; inhibition site 391619007567 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391619007568 catalytic residue [active] 391619007569 EamA-like transporter family; Region: EamA; pfam00892 391619007570 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391619007571 ABC-2 type transporter; Region: ABC2_membrane; cl17235 391619007572 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 391619007573 GcrA cell cycle regulator; Region: GcrA; cl11564 391619007574 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 391619007575 putative S-transferase; Provisional; Region: PRK11752 391619007576 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 391619007577 C-terminal domain interface [polypeptide binding]; other site 391619007578 GSH binding site (G-site) [chemical binding]; other site 391619007579 dimer interface [polypeptide binding]; other site 391619007580 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 391619007581 dimer interface [polypeptide binding]; other site 391619007582 N-terminal domain interface [polypeptide binding]; other site 391619007583 active site 391619007584 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 391619007585 ligand binding site [chemical binding]; other site 391619007586 active site 391619007587 ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134 391619007588 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391619007589 Walker A/P-loop; other site 391619007590 ATP binding site [chemical binding]; other site 391619007591 Q-loop/lid; other site 391619007592 ABC transporter signature motif; other site 391619007593 Walker B; other site 391619007594 D-loop; other site 391619007595 H-loop/switch region; other site 391619007596 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 391619007597 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 391619007598 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 391619007599 Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109 391619007600 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 391619007601 active site 391619007602 substrate binding site [chemical binding]; other site 391619007603 metal binding site [ion binding]; metal-binding site 391619007604 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 391619007605 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 391619007606 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 391619007607 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 391619007608 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391619007609 FeS/SAM binding site; other site 391619007610 Protein of unknown function, DUF393; Region: DUF393; pfam04134 391619007611 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 391619007612 Peptidase family M48; Region: Peptidase_M48; cl12018 391619007613 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 391619007614 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514 391619007615 FMN binding site [chemical binding]; other site 391619007616 dimer interface [polypeptide binding]; other site 391619007617 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 391619007618 Protein of unknown function (DUF1467); Region: DUF1467; pfam07330 391619007619 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391619007620 Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249 391619007621 dimer interface [polypeptide binding]; other site 391619007622 substrate binding site [chemical binding]; other site 391619007623 metal binding site [ion binding]; metal-binding site 391619007624 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 391619007625 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391619007626 active site 391619007627 phosphorylation site [posttranslational modification] 391619007628 intermolecular recognition site; other site 391619007629 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102 391619007630 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 391619007631 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 391619007632 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 391619007633 dimer interface [polypeptide binding]; other site 391619007634 anticodon binding site; other site 391619007635 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 391619007636 motif 1; other site 391619007637 dimer interface [polypeptide binding]; other site 391619007638 active site 391619007639 motif 2; other site 391619007640 GAD domain; Region: GAD; pfam02938 391619007641 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 391619007642 active site 391619007643 motif 3; other site 391619007644 hypothetical protein; Provisional; Region: PRK07546 391619007645 substrate-cofactor binding pocket; other site 391619007646 homodimer interface [polypeptide binding]; other site 391619007647 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 391619007648 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391619007649 catalytic residue [active] 391619007650 aminodeoxychorismate synthase; Provisional; Region: PRK07508 391619007651 chorismate binding enzyme; Region: Chorismate_bind; cl10555 391619007652 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 391619007653 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391619007654 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 391619007655 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 391619007656 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 391619007657 ATP-grasp domain; Region: ATP-grasp_4; cl17255 391619007658 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 391619007659 IMP binding site; other site 391619007660 dimer interface [polypeptide binding]; other site 391619007661 partial ornithine binding site; other site 391619007662 putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418 391619007663 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391619007664 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391619007665 dimerization interface [polypeptide binding]; other site 391619007666 Glycine/serine hydroxymethyltransferase [Amino acid transport and metabolism]; Region: GlyA; COG0112 391619007667 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391619007668 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391619007669 catalytic residue [active] 391619007670 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 391619007671 active site 391619007672 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 391619007673 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 391619007674 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 391619007675 HlyD family secretion protein; Region: HlyD_3; pfam13437 391619007676 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 391619007677 MarR family; Region: MarR; pfam01047 391619007678 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515 391619007679 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 391619007680 dimer interface [polypeptide binding]; other site 391619007681 active site 391619007682 CoA binding pocket [chemical binding]; other site 391619007683 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 391619007684 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 391619007685 thymidine kinase; Provisional; Region: PRK04296 391619007686 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 391619007687 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 391619007688 dimerization interface [polypeptide binding]; other site 391619007689 ligand binding site [chemical binding]; other site 391619007690 NADP binding site [chemical binding]; other site 391619007691 catalytic site [active] 391619007692 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 391619007693 dimer interface [polypeptide binding]; other site 391619007694 putative tRNA-binding site [nucleotide binding]; other site 391619007695 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 391619007696 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 391619007697 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 391619007698 Membrane fusogenic activity; Region: BMFP; pfam04380 391619007699 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 391619007700 Uncharacterized conserved protein [Function unknown]; Region: COG1565 391619007701 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 391619007702 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578 391619007703 Hint domain; Region: Hint_2; pfam13403 391619007704 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391619007705 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391619007706 putative DNA binding site [nucleotide binding]; other site 391619007707 putative Zn2+ binding site [ion binding]; other site 391619007708 AsnC family; Region: AsnC_trans_reg; pfam01037 391619007709 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 391619007710 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391619007711 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391619007712 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220 391619007713 Transcriptional regulators [Transcription]; Region: MarR; COG1846 391619007714 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Validated; Region: PRK05537 391619007715 ATP-sulfurylase; Region: ATPS; cd00517 391619007716 active site 391619007717 HXXH motif; other site 391619007718 flexible loop; other site 391619007719 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 391619007720 ligand-binding site [chemical binding]; other site 391619007721 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 391619007722 Protein of unknown function (DUF1150); Region: DUF1150; pfam06620 391619007723 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 391619007724 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 391619007725 putative dimer interface [polypeptide binding]; other site 391619007726 AIR carboxylase; Region: AIRC; pfam00731 391619007727 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 391619007728 ATP-grasp domain; Region: ATP-grasp; pfam02222 391619007729 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 391619007730 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391619007731 active site 391619007732 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391619007733 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 391619007734 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 391619007735 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 391619007736 ring oligomerisation interface [polypeptide binding]; other site 391619007737 ATP/Mg binding site [chemical binding]; other site 391619007738 stacking interactions; other site 391619007739 hinge regions; other site 391619007740 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 391619007741 oligomerisation interface [polypeptide binding]; other site 391619007742 mobile loop; other site 391619007743 roof hairpin; other site 391619007744 Uncharacterized conserved protein (DUF2161); Region: DUF2161; pfam09929 391619007745 putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427 391619007746 DHH family; Region: DHH; pfam01368 391619007747 DHHA2 domain; Region: DHHA2; pfam02833 391619007748 HAMP domain; Region: HAMP; pfam00672 391619007749 dimerization interface [polypeptide binding]; other site 391619007750 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 391619007751 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 391619007752 dimer interface [polypeptide binding]; other site 391619007753 putative CheW interface [polypeptide binding]; other site 391619007754 HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4 391619007755 Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344 391619007756 HAD-hyrolase-like; Region: Hydrolase_like; pfam13242 391619007757 (R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449 391619007758 dimer interaction site [polypeptide binding]; other site 391619007759 substrate-binding tunnel; other site 391619007760 active site 391619007761 catalytic site [active] 391619007762 substrate binding site [chemical binding]; other site 391619007763 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 391619007764 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 391619007765 active site 391619007766 Riboflavin kinase; Region: Flavokinase; pfam01687 391619007767 hypothetical protein; Provisional; Region: PRK05170 391619007768 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 391619007769 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 391619007770 tetramer interface [polypeptide binding]; other site 391619007771 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391619007772 catalytic residue [active] 391619007773 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391619007774 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391619007775 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391619007776 dimerization interface [polypeptide binding]; other site 391619007777 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391619007778 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 391619007779 catalytic site [active] 391619007780 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 391619007781 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 391619007782 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391619007783 active site 391619007784 Uncharacterized conserved protein [Function unknown]; Region: COG3791 391619007785 H-type lectin domain; Region: H_lectin; pfam09458 391619007786 F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13443 391619007787 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 391619007788 gamma subunit interface [polypeptide binding]; other site 391619007789 epsilon subunit interface [polypeptide binding]; other site 391619007790 LBP interface [polypeptide binding]; other site 391619007791 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 391619007792 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 391619007793 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 391619007794 alpha subunit interaction interface [polypeptide binding]; other site 391619007795 Walker A motif; other site 391619007796 ATP binding site [chemical binding]; other site 391619007797 Walker B motif; other site 391619007798 inhibitor binding site; inhibition site 391619007799 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 391619007800 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 391619007801 core domain interface [polypeptide binding]; other site 391619007802 delta subunit interface [polypeptide binding]; other site 391619007803 epsilon subunit interface [polypeptide binding]; other site 391619007804 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 391619007805 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 391619007806 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 391619007807 beta subunit interaction interface [polypeptide binding]; other site 391619007808 Walker A motif; other site 391619007809 ATP binding site [chemical binding]; other site 391619007810 Walker B motif; other site 391619007811 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 391619007812 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 391619007813 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 391619007814 Methyltransferase domain; Region: Methyltransf_23; pfam13489 391619007815 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 391619007816 hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413 391619007817 ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639 391619007818 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391619007819 Walker A motif; other site 391619007820 ATP binding site [chemical binding]; other site 391619007821 Walker B motif; other site 391619007822 arginine finger; other site 391619007823 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391619007824 Walker A motif; other site 391619007825 ATP binding site [chemical binding]; other site 391619007826 Walker B motif; other site 391619007827 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 391619007828 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 391619007829 Peptidase family M23; Region: Peptidase_M23; pfam01551 391619007830 Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860 391619007831 hypothetical protein; Validated; Region: PRK09039 391619007832 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 391619007833 ligand binding site [chemical binding]; other site 391619007834 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 391619007835 putative active site pocket [active] 391619007836 dimerization interface [polypeptide binding]; other site 391619007837 putative catalytic residue [active] 391619007838 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093 391619007839 Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898 391619007840 Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904 391619007841 cyclohexadienyl dehydrogenase; Validated; Region: PRK07502 391619007842 prephenate dehydrogenase; Validated; Region: PRK08507 391619007843 histidinol-phosphate aminotransferase; Validated; Region: PRK02731 391619007844 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391619007845 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391619007846 homodimer interface [polypeptide binding]; other site 391619007847 catalytic residue [active] 391619007848 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391619007849 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 391619007850 AsnC family; Region: AsnC_trans_reg; pfam01037 391619007851 PA14 domain; Region: PA14; cl08459 391619007852 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 391619007853 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 391619007854 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 391619007855 RNA binding surface [nucleotide binding]; other site 391619007856 Hint domain; Region: Hint_2; pfam13403 391619007857 Long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07059 391619007858 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 391619007859 acyl-activating enzyme (AAE) consensus motif; other site 391619007860 putative AMP binding site [chemical binding]; other site 391619007861 putative active site [active] 391619007862 putative CoA binding site [chemical binding]; other site 391619007863 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 391619007864 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_3; cd06217 391619007865 FAD binding pocket [chemical binding]; other site 391619007866 FAD binding motif [chemical binding]; other site 391619007867 phosphate binding motif [ion binding]; other site 391619007868 beta-alpha-beta structure motif; other site 391619007869 NAD binding pocket [chemical binding]; other site 391619007870 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391619007871 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 391619007872 catalytic loop [active] 391619007873 iron binding site [ion binding]; other site 391619007874 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 391619007875 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391619007876 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 391619007877 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 391619007878 active site 391619007879 FMN binding site [chemical binding]; other site 391619007880 2,4-decadienoyl-CoA binding site; other site 391619007881 catalytic residue [active] 391619007882 4Fe-4S cluster binding site [ion binding]; other site 391619007883 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391619007884 bile acid transporter; Region: bass; TIGR00841 391619007885 Sodium Bile acid symporter family; Region: SBF; cl17470 391619007886 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391619007887 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391619007888 WHG domain; Region: WHG; pfam13305 391619007889 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 391619007890 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391619007891 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 391619007892 DNA binding residues [nucleotide binding] 391619007893 Integrase core domain; Region: rve; pfam00665 391619007894 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 391619007895 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391619007896 Walker A motif; other site 391619007897 ATP binding site [chemical binding]; other site 391619007898 Walker B motif; other site 391619007899 arginine finger; other site 391619007900 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391619007901 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391619007902 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391619007903 dimerization interface [polypeptide binding]; other site 391619007904 Sulfatase; Region: Sulfatase; cl17466 391619007905 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 391619007906 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391619007907 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 391619007908 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 391619007909 Amidase; Region: Amidase; cl11426 391619007910 histidinol dehydrogenase; Region: hisD; TIGR00069 391619007911 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 391619007912 NAD binding site [chemical binding]; other site 391619007913 dimerization interface [polypeptide binding]; other site 391619007914 product binding site; other site 391619007915 substrate binding site [chemical binding]; other site 391619007916 zinc binding site [ion binding]; other site 391619007917 catalytic residues [active] 391619007918 aspartate racemase; Region: asp_race; TIGR00035 391619007919 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 391619007920 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 391619007921 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391619007922 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391619007923 catalytic residue [active] 391619007924 D-cysteine desulfhydrase; Validated; Region: PRK03910 391619007925 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 391619007926 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391619007927 catalytic residue [active] 391619007928 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 391619007929 conserved cys residue [active] 391619007930 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 391619007931 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391619007932 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391619007933 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391619007934 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 391619007935 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391619007936 Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385 391619007937 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391619007938 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391619007939 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 391619007940 dimerization interface [polypeptide binding]; other site 391619007941 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113 391619007942 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 391619007943 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619007944 dimer interface [polypeptide binding]; other site 391619007945 conserved gate region; other site 391619007946 putative PBP binding loops; other site 391619007947 ABC-ATPase subunit interface; other site 391619007948 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391619007949 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 391619007950 Walker A/P-loop; other site 391619007951 ATP binding site [chemical binding]; other site 391619007952 Q-loop/lid; other site 391619007953 ABC transporter signature motif; other site 391619007954 Walker B; other site 391619007955 D-loop; other site 391619007956 H-loop/switch region; other site 391619007957 PemK-like protein; Region: PemK; pfam02452 391619007958 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 391619007959 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 391619007960 catalytic residues [active] 391619007961 catalytic nucleophile [active] 391619007962 Recombinase; Region: Recombinase; pfam07508 391619007963 mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997 391619007964 Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734 391619007965 putative active site [active] 391619007966 putative FMN binding site [chemical binding]; other site 391619007967 putative substrate binding site [chemical binding]; other site 391619007968 putative catalytic residue [active] 391619007969 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391619007970 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391619007971 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391619007972 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391619007973 dimerization interface [polypeptide binding]; other site 391619007974 Protein of unknown function (DUF1330); Region: DUF1330; pfam07045 391619007975 Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383 391619007976 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391619007977 catalytic loop [active] 391619007978 iron binding site [ion binding]; other site 391619007979 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929 391619007980 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 391619007981 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 391619007982 [4Fe-4S] binding site [ion binding]; other site 391619007983 molybdopterin cofactor binding site; other site 391619007984 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 391619007985 molybdopterin cofactor binding site; other site 391619007986 NADH dehydrogenase subunit E; Validated; Region: PRK07539 391619007987 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E family, Tungsten-containing formate dehydrogenase (W-FDH) beta subunit; composed of proteins similar to the W-FDH beta subunit of Methylobacterium extorquens. W-FDH...; Region: TRX_Fd_NuoE_W_FDH_beta; cd03082 391619007988 putative dimer interface [polypeptide binding]; other site 391619007989 [2Fe-2S] cluster binding site [ion binding]; other site 391619007990 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 391619007991 SLBB domain; Region: SLBB; pfam10531 391619007992 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 391619007993 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 391619007994 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391619007995 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 391619007996 MarR family; Region: MarR_2; cl17246 391619007997 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 391619007998 dimerization interface [polypeptide binding]; other site 391619007999 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 391619008000 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 391619008001 dimer interface [polypeptide binding]; other site 391619008002 putative CheW interface [polypeptide binding]; other site 391619008003 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391619008004 S-adenosylmethionine binding site [chemical binding]; other site 391619008005 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 391619008006 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 391619008007 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 391619008008 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391619008009 Coenzyme A binding pocket [chemical binding]; other site 391619008010 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 391619008011 active site 391619008012 catalytic residues [active] 391619008013 DNA binding site [nucleotide binding] 391619008014 Int/Topo IB signature motif; other site 391619008015 Phage-related protein [Function unknown]; Region: COG4695 391619008016 Phage portal protein; Region: Phage_portal; pfam04860 391619008017 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 391619008018 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 391619008019 oligomerization interface [polypeptide binding]; other site 391619008020 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 391619008021 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 391619008022 intersubunit interface [polypeptide binding]; other site 391619008023 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 391619008024 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 391619008025 ABC-ATPase subunit interface; other site 391619008026 dimer interface [polypeptide binding]; other site 391619008027 putative PBP binding regions; other site 391619008028 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 391619008029 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 391619008030 ABC-ATPase subunit interface; other site 391619008031 dimer interface [polypeptide binding]; other site 391619008032 putative PBP binding regions; other site 391619008033 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 391619008034 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 391619008035 Walker A/P-loop; other site 391619008036 ATP binding site [chemical binding]; other site 391619008037 Q-loop/lid; other site 391619008038 ABC transporter signature motif; other site 391619008039 Walker B; other site 391619008040 D-loop; other site 391619008041 H-loop/switch region; other site 391619008042 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 391619008043 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 391619008044 FAD binding pocket [chemical binding]; other site 391619008045 FAD binding motif [chemical binding]; other site 391619008046 phosphate binding motif [ion binding]; other site 391619008047 NAD binding pocket [chemical binding]; other site 391619008048 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 391619008049 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 391619008050 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 391619008051 TonB C terminal; Region: TonB_2; pfam13103 391619008052 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 391619008053 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 391619008054 N-terminal plug; other site 391619008055 ligand-binding site [chemical binding]; other site 391619008056 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 391619008057 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322 391619008058 FAD binding pocket [chemical binding]; other site 391619008059 conserved FAD binding motif [chemical binding]; other site 391619008060 phosphate binding motif [ion binding]; other site 391619008061 beta-alpha-beta structure motif; other site 391619008062 NAD binding pocket [chemical binding]; other site 391619008063 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 391619008064 MarR family; Region: MarR_2; pfam12802 391619008065 potential frameshift: common BLAST hit: gi|209967123|ref|YP_002300038.1| transcriptional regulator, MarR family protein 391619008066 MarR family; Region: MarR_2; cl17246 391619008067 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 391619008068 EF-hand domain pair; Region: EF_hand_5; pfam13499 391619008069 Ca2+ binding site [ion binding]; other site 391619008070 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 391619008071 Domain of unknown function (DUF1772); Region: DUF1772; cl12097 391619008072 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 391619008073 Uncharacterized protein family (UPF0160); Region: UPF0160; pfam03690 391619008074 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 391619008075 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 391619008076 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 391619008077 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 391619008078 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 391619008079 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 391619008080 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 391619008081 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 391619008082 active site 391619008083 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 391619008084 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 391619008085 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 391619008086 ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800 391619008087 Myosin and Kinesin motor domain. These ATPases belong to the P-loop NTPase family and provide the driving force in myosin and kinesin mediated processes; Region: Motor_domain; cl00286 391619008088 excinuclease ABC subunit B; Provisional; Region: PRK05298 391619008089 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391619008090 ATP-binding site [chemical binding]; other site 391619008091 ATP binding site [chemical binding]; other site 391619008092 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391619008093 nucleotide binding region [chemical binding]; other site 391619008094 ATP-binding site [chemical binding]; other site 391619008095 Ultra-violet resistance protein B; Region: UvrB; pfam12344 391619008096 UvrB/uvrC motif; Region: UVR; pfam02151 391619008097 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 391619008098 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391619008099 Ligand Binding Site [chemical binding]; other site 391619008100 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 391619008101 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 391619008102 lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750 391619008103 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391619008104 active site 391619008105 nucleotide binding site [chemical binding]; other site 391619008106 HIGH motif; other site 391619008107 KMSKS motif; other site 391619008108 tellurite resistance protein terB; Region: terB; cd07176 391619008109 putative metal binding site [ion binding]; other site 391619008110 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 391619008111 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391619008112 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 391619008113 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 391619008114 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 391619008115 active site 391619008116 (T/H)XGH motif; other site 391619008117 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 391619008118 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391619008119 Walker A/P-loop; other site 391619008120 ATP binding site [chemical binding]; other site 391619008121 Q-loop/lid; other site 391619008122 ABC transporter signature motif; other site 391619008123 Walker B; other site 391619008124 D-loop; other site 391619008125 H-loop/switch region; other site 391619008126 ABC transporter; Region: ABC_tran_2; pfam12848 391619008127 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 391619008128 thioredoxin 2; Provisional; Region: PRK10996 391619008129 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 391619008130 catalytic residues [active] 391619008131 Protein of unknown function (DUF3573); Region: DUF3573; pfam12097 391619008132 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 391619008133 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 391619008134 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 391619008135 DNA-binding site [nucleotide binding]; DNA binding site 391619008136 RNA-binding motif; other site 391619008137 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 391619008138 active site 391619008139 catalytic triad [active] 391619008140 oxyanion hole [active] 391619008141 switch loop; other site 391619008142 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181 391619008143 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 391619008144 Walker A/P-loop; other site 391619008145 ATP binding site [chemical binding]; other site 391619008146 Q-loop/lid; other site 391619008147 ABC transporter signature motif; other site 391619008148 Walker B; other site 391619008149 D-loop; other site 391619008150 H-loop/switch region; other site 391619008151 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 391619008152 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 391619008153 Predicted transcriptional regulator [Transcription]; Region: COG1959 391619008154 Transcriptional regulator; Region: Rrf2; cl17282 391619008155 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 391619008156 putative active site pocket [active] 391619008157 dimerization interface [polypeptide binding]; other site 391619008158 putative catalytic residue [active] 391619008159 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 391619008160 Predicted membrane protein [Function unknown]; Region: COG4325 391619008161 glutamyl-tRNA synthetase; Provisional; Region: PRK12558 391619008162 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391619008163 active site 391619008164 HIGH motif; other site 391619008165 nucleotide binding site [chemical binding]; other site 391619008166 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 391619008167 active site 391619008168 KMSKS motif; other site 391619008169 PAS fold; Region: PAS_7; pfam12860 391619008170 GAF domain; Region: GAF_3; pfam13492 391619008171 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 391619008172 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391619008173 metal binding site [ion binding]; metal-binding site 391619008174 active site 391619008175 I-site; other site 391619008176 NAD synthetase; Provisional; Region: PRK13981 391619008177 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 391619008178 multimer interface [polypeptide binding]; other site 391619008179 active site 391619008180 catalytic triad [active] 391619008181 protein interface 1 [polypeptide binding]; other site 391619008182 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 391619008183 homodimer interface [polypeptide binding]; other site 391619008184 NAD binding pocket [chemical binding]; other site 391619008185 ATP binding pocket [chemical binding]; other site 391619008186 Mg binding site [ion binding]; other site 391619008187 active-site loop [active] 391619008188 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 391619008189 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 391619008190 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 391619008191 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642 391619008192 2-isopropylmalate synthase; Validated; Region: PRK00915 391619008193 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 391619008194 active site 391619008195 catalytic residues [active] 391619008196 metal binding site [ion binding]; metal-binding site 391619008197 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 391619008198 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 391619008199 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 391619008200 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 391619008201 rod shape-determining protein MreB; Provisional; Region: PRK13927 391619008202 MreB and similar proteins; Region: MreB_like; cd10225 391619008203 nucleotide binding site [chemical binding]; other site 391619008204 Mg binding site [ion binding]; other site 391619008205 putative protofilament interaction site [polypeptide binding]; other site 391619008206 RodZ interaction site [polypeptide binding]; other site 391619008207 rod shape-determining protein MreC; Provisional; Region: PRK13922 391619008208 rod shape-determining protein MreC; Region: MreC; pfam04085 391619008209 penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423 391619008210 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 391619008211 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 391619008212 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 391619008213 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391619008214 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391619008215 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391619008216 dimerization interface [polypeptide binding]; other site 391619008217 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391619008218 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357 391619008219 putative metal binding site [ion binding]; other site 391619008220 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 391619008221 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 391619008222 putative ligand binding site [chemical binding]; other site 391619008223 NAD binding site [chemical binding]; other site 391619008224 dimerization interface [polypeptide binding]; other site 391619008225 catalytic site [active] 391619008226 Tryptophan halogenase; Region: Trp_halogenase; pfam04820 391619008227 Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339 391619008228 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 391619008229 active site 391619008230 Zn binding site [ion binding]; other site 391619008231 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619008232 dimer interface [polypeptide binding]; other site 391619008233 conserved gate region; other site 391619008234 putative PBP binding loops; other site 391619008235 ABC-ATPase subunit interface; other site 391619008236 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391619008237 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391619008238 substrate binding pocket [chemical binding]; other site 391619008239 membrane-bound complex binding site; other site 391619008240 hinge residues; other site 391619008241 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 391619008242 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 391619008243 ATP binding site [chemical binding]; other site 391619008244 substrate interface [chemical binding]; other site 391619008245 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 391619008246 trimer interface [polypeptide binding]; other site 391619008247 active site 391619008248 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 391619008249 Flavoprotein; Region: Flavoprotein; pfam02441 391619008250 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 391619008251 Protein of unknown function, DUF399; Region: DUF399; pfam04187 391619008252 RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500 391619008253 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391619008254 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391619008255 DNA binding residues [nucleotide binding] 391619008256 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 391619008257 homotrimer interface [polypeptide binding]; other site 391619008258 Walker A motif; other site 391619008259 GTP binding site [chemical binding]; other site 391619008260 Walker B motif; other site 391619008261 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 391619008262 catalytic core [active] 391619008263 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 391619008264 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 391619008265 C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194 391619008266 putative N-terminal domain interface [polypeptide binding]; other site 391619008267 putative dimer interface [polypeptide binding]; other site 391619008268 putative substrate binding pocket (H-site) [chemical binding]; other site 391619008269 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 391619008270 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 391619008271 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391619008272 Walker A motif; other site 391619008273 ATP binding site [chemical binding]; other site 391619008274 Walker B motif; other site 391619008275 arginine finger; other site 391619008276 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 391619008277 glutathione synthetase; Provisional; Region: PRK05246 391619008278 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 391619008279 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 391619008280 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 391619008281 Predicted methyltransferases [General function prediction only]; Region: COG0313 391619008282 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 391619008283 putative SAM binding site [chemical binding]; other site 391619008284 putative homodimer interface [polypeptide binding]; other site 391619008285 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 391619008286 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 391619008287 putative ligand binding site [chemical binding]; other site 391619008288 PII uridylyl-transferase; Provisional; Region: PRK05092 391619008289 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 391619008290 metal binding triad; other site 391619008291 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 391619008292 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 391619008293 Zn2+ binding site [ion binding]; other site 391619008294 Mg2+ binding site [ion binding]; other site 391619008295 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 391619008296 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 391619008297 Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728 391619008298 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 391619008299 Rhomboid family; Region: Rhomboid; cl11446 391619008300 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 391619008301 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 391619008302 active site 391619008303 HIGH motif; other site 391619008304 dimer interface [polypeptide binding]; other site 391619008305 KMSKS motif; other site 391619008306 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 391619008307 DNA-binding site [nucleotide binding]; DNA binding site 391619008308 RNA-binding motif; other site 391619008309 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391619008310 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391619008311 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 391619008312 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 391619008313 active site 391619008314 AMP binding site [chemical binding]; other site 391619008315 homodimer interface [polypeptide binding]; other site 391619008316 acyl-activating enzyme (AAE) consensus motif; other site 391619008317 CoA binding site [chemical binding]; other site 391619008318 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 391619008319 CoenzymeA binding site [chemical binding]; other site 391619008320 subunit interaction site [polypeptide binding]; other site 391619008321 PHB binding site; other site 391619008322 enoyl-CoA hydratase; Provisional; Region: PRK08140 391619008323 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391619008324 substrate binding site [chemical binding]; other site 391619008325 oxyanion hole (OAH) forming residues; other site 391619008326 trimer interface [polypeptide binding]; other site 391619008327 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 391619008328 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 391619008329 substrate binding site [chemical binding]; other site 391619008330 dimer interface [polypeptide binding]; other site 391619008331 NADP binding site [chemical binding]; other site 391619008332 catalytic residues [active] 391619008333 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 391619008334 active site 2 [active] 391619008335 active site 1 [active] 391619008336 PaaX-like protein; Region: PaaX; pfam07848 391619008337 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 391619008338 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 391619008339 dimer interface [polypeptide binding]; other site 391619008340 [2Fe-2S] cluster binding site [ion binding]; other site 391619008341 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 391619008342 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 391619008343 Walker A/P-loop; other site 391619008344 ATP binding site [chemical binding]; other site 391619008345 Q-loop/lid; other site 391619008346 ABC transporter signature motif; other site 391619008347 Walker B; other site 391619008348 D-loop; other site 391619008349 H-loop/switch region; other site 391619008350 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 391619008351 Metal binding protein TroA_a. These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148 391619008352 putative ligand binding residues [chemical binding]; other site 391619008353 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 391619008354 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 391619008355 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 391619008356 dimer interface [polypeptide binding]; other site 391619008357 putative PBP binding regions; other site 391619008358 ABC-ATPase subunit interface; other site 391619008359 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 391619008360 homotrimer interaction site [polypeptide binding]; other site 391619008361 putative active site [active] 391619008362 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 391619008363 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 391619008364 putative ligand binding site [chemical binding]; other site 391619008365 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 391619008366 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 391619008367 Walker A/P-loop; other site 391619008368 ATP binding site [chemical binding]; other site 391619008369 Q-loop/lid; other site 391619008370 ABC transporter signature motif; other site 391619008371 Walker B; other site 391619008372 D-loop; other site 391619008373 H-loop/switch region; other site 391619008374 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 391619008375 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391619008376 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 391619008377 TM-ABC transporter signature motif; other site 391619008378 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391619008379 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 391619008380 TM-ABC transporter signature motif; other site 391619008381 cytosine deaminase; Validated; Region: PRK07572 391619008382 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 391619008383 active site 391619008384 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 391619008385 BON domain; Region: BON; pfam04972 391619008386 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 391619008387 Mechanosensitive ion channel; Region: MS_channel; pfam00924 391619008388 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 391619008389 Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871 391619008390 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 391619008391 CsbD-like; Region: CsbD; cl17424 391619008392 Protein of unknown function (DUF1469); Region: DUF1469; pfam07332 391619008393 Protein of unknown function (DUF3619); Region: DUF3619; pfam12279 391619008394 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 391619008395 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 391619008396 putative active site [active] 391619008397 catalytic site [active] 391619008398 Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105 391619008399 PLD-like domain; Region: PLDc_2; pfam13091 391619008400 putative active site [active] 391619008401 catalytic site [active] 391619008402 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 391619008403 Histidine kinase; Region: HisKA_2; pfam07568 391619008404 RNA polymerase sigma factor; Provisional; Region: PRK12546 391619008405 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391619008406 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391619008407 DNA binding residues [nucleotide binding] 391619008408 two-component response regulator; Provisional; Region: PRK09191 391619008409 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 391619008410 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391619008411 active site 391619008412 phosphorylation site [posttranslational modification] 391619008413 intermolecular recognition site; other site 391619008414 dimerization interface [polypeptide binding]; other site 391619008415 Ferritin-like domain; Region: Ferritin; pfam00210 391619008416 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 391619008417 dimerization interface [polypeptide binding]; other site 391619008418 DPS ferroxidase diiron center [ion binding]; other site 391619008419 ion pore; other site 391619008420 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 391619008421 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 391619008422 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 391619008423 putative active site [active] 391619008424 N-formylglutamate amidohydrolase; Region: FGase; cl01522 391619008425 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181 391619008426 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 391619008427 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 391619008428 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391619008429 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 391619008430 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 391619008431 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 391619008432 Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102 391619008433 NAD(P) binding site [chemical binding]; other site 391619008434 catalytic residues [active] 391619008435 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 391619008436 Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192 391619008437 putative active site [active] 391619008438 metal binding site [ion binding]; metal-binding site 391619008439 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 391619008440 Zn2+ binding site [ion binding]; other site 391619008441 Mg2+ binding site [ion binding]; other site 391619008442 gamma-butyrobetaine hydroxylase; Region: carnitine_bodg; TIGR02409 391619008443 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 391619008444 substrate binding pocket [chemical binding]; other site 391619008445 active site 391619008446 iron coordination sites [ion binding]; other site 391619008447 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391619008448 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391619008449 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391619008450 dimerization interface [polypeptide binding]; other site 391619008451 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 391619008452 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391619008453 active site 391619008454 phosphorylation site [posttranslational modification] 391619008455 intermolecular recognition site; other site 391619008456 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391619008457 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391619008458 ATP binding site [chemical binding]; other site 391619008459 Mg2+ binding site [ion binding]; other site 391619008460 G-X-G motif; other site 391619008461 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391619008462 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391619008463 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 391619008464 dimerization interface [polypeptide binding]; other site 391619008465 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391619008466 dimer interface [polypeptide binding]; other site 391619008467 phosphorylation site [posttranslational modification] 391619008468 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391619008469 ATP binding site [chemical binding]; other site 391619008470 Mg2+ binding site [ion binding]; other site 391619008471 G-X-G motif; other site 391619008472 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391619008473 Response regulator receiver domain; Region: Response_reg; pfam00072 391619008474 active site 391619008475 phosphorylation site [posttranslational modification] 391619008476 intermolecular recognition site; other site 391619008477 dimerization interface [polypeptide binding]; other site 391619008478 Amidohydrolase; Region: Amidohydro_2; pfam04909 391619008479 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 391619008480 SnoaL-like domain; Region: SnoaL_2; pfam12680 391619008481 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 391619008482 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 391619008483 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 391619008484 Walker A/P-loop; other site 391619008485 ATP binding site [chemical binding]; other site 391619008486 Q-loop/lid; other site 391619008487 ABC transporter signature motif; other site 391619008488 Walker B; other site 391619008489 D-loop; other site 391619008490 H-loop/switch region; other site 391619008491 TOBE domain; Region: TOBE_2; pfam08402 391619008492 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391619008493 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391619008494 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619008495 dimer interface [polypeptide binding]; other site 391619008496 conserved gate region; other site 391619008497 ABC-ATPase subunit interface; other site 391619008498 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391619008499 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619008500 dimer interface [polypeptide binding]; other site 391619008501 conserved gate region; other site 391619008502 putative PBP binding loops; other site 391619008503 ABC-ATPase subunit interface; other site 391619008504 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 391619008505 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 391619008506 histidinol dehydrogenase; Region: hisD; TIGR00069 391619008507 NAD binding site [chemical binding]; other site 391619008508 dimerization interface [polypeptide binding]; other site 391619008509 product binding site; other site 391619008510 substrate binding site [chemical binding]; other site 391619008511 zinc binding site [ion binding]; other site 391619008512 catalytic residues [active] 391619008513 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 391619008514 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 391619008515 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391619008516 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391619008517 NAD(P) binding site [chemical binding]; other site 391619008518 active site 391619008519 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391619008520 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391619008521 DNA binding site [nucleotide binding] 391619008522 domain linker motif; other site 391619008523 Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278 391619008524 putative dimerization interface [polypeptide binding]; other site 391619008525 putative ligand binding site [chemical binding]; other site 391619008526 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 391619008527 SnoaL-like domain; Region: SnoaL_2; pfam12680 391619008528 Cupin domain; Region: Cupin_2; pfam07883 391619008529 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 391619008530 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 391619008531 substrate binding site [chemical binding]; other site 391619008532 THF binding site; other site 391619008533 zinc-binding site [ion binding]; other site 391619008534 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 391619008535 TAP-like protein; Region: Abhydrolase_4; pfam08386 391619008536 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 391619008537 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 391619008538 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 391619008539 dimer interface [polypeptide binding]; other site 391619008540 putative CheW interface [polypeptide binding]; other site 391619008541 Nitrate and nitrite sensing; Region: NIT; pfam08376 391619008542 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 391619008543 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 391619008544 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 391619008545 anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451 391619008546 ChrR Cupin-like domain; Region: Cupin_7; pfam12973 391619008547 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 391619008548 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391619008549 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 391619008550 DNA binding residues [nucleotide binding] 391619008551 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 391619008552 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391619008553 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391619008554 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 391619008555 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 391619008556 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391619008557 S-adenosylmethionine binding site [chemical binding]; other site 391619008558 MFS/sugar transport protein; Region: MFS_2; pfam13347 391619008559 Protein of unknown function (DUF3833); Region: DUF3833; pfam12915 391619008560 Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300 391619008561 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391619008562 NAD(P) binding site [chemical binding]; other site 391619008563 active site 391619008564 carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325 391619008565 NADP binding site [chemical binding]; other site 391619008566 homodimer interface [polypeptide binding]; other site 391619008567 active site 391619008568 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 391619008569 dimerization interface [polypeptide binding]; other site 391619008570 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391619008571 dimer interface [polypeptide binding]; other site 391619008572 phosphorylation site [posttranslational modification] 391619008573 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391619008574 ATP binding site [chemical binding]; other site 391619008575 Mg2+ binding site [ion binding]; other site 391619008576 G-X-G motif; other site 391619008577 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 391619008578 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391619008579 active site 391619008580 phosphorylation site [posttranslational modification] 391619008581 intermolecular recognition site; other site 391619008582 dimerization interface [polypeptide binding]; other site 391619008583 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391619008584 Walker A motif; other site 391619008585 ATP binding site [chemical binding]; other site 391619008586 Walker B motif; other site 391619008587 arginine finger; other site 391619008588 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 391619008589 FOG: WD40 repeat [General function prediction only]; Region: COG2319 391619008590 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 391619008591 structural tetrad; other site 391619008592 Cytochrome c; Region: Cytochrom_C; cl11414 391619008593 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 391619008594 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 391619008595 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 391619008596 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 391619008597 [4Fe-4S] binding site [ion binding]; other site 391619008598 molybdopterin cofactor binding site; other site 391619008599 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 391619008600 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 391619008601 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 391619008602 molybdopterin cofactor binding site; other site 391619008603 Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613 391619008604 Protein of unknown function (DUF3306); Region: DUF3306; pfam11748 391619008605 Protein of unknown function (DUF3305); Region: DUF3305; pfam11749 391619008606 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 391619008607 4Fe-4S binding domain; Region: Fer4; pfam00037 391619008608 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 391619008609 4Fe-4S binding domain; Region: Fer4; pfam00037 391619008610 antiporter inner membrane protein; Provisional; Region: PRK11670 391619008611 Domain of unknown function DUF59; Region: DUF59; pfam01883 391619008612 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 391619008613 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 391619008614 PBP superfamily domain; Region: PBP_like_2; pfam12849 391619008615 phosphate transporter ATP-binding protein; Provisional; Region: PRK14242 391619008616 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391619008617 Walker A/P-loop; other site 391619008618 ATP binding site [chemical binding]; other site 391619008619 Q-loop/lid; other site 391619008620 ABC transporter signature motif; other site 391619008621 Walker B; other site 391619008622 D-loop; other site 391619008623 H-loop/switch region; other site 391619008624 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 391619008625 quinolinate synthetase; Provisional; Region: PRK09375 391619008626 L-aspartate oxidase; Provisional; Region: PRK06175 391619008627 L-aspartate oxidase; Provisional; Region: PRK07512 391619008628 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 391619008629 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 391619008630 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 391619008631 dimerization interface [polypeptide binding]; other site 391619008632 active site 391619008633 Methyltransferase domain; Region: Methyltransf_23; pfam13489 391619008634 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 391619008635 GtrA-like protein; Region: GtrA; pfam04138 391619008636 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 391619008637 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 391619008638 Ligand binding site; other site 391619008639 Putative Catalytic site; other site 391619008640 DXD motif; other site 391619008641 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 391619008642 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 391619008643 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 391619008644 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 391619008645 CoA-transferase family III; Region: CoA_transf_3; pfam02515 391619008646 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391619008647 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 391619008648 active site 391619008649 Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222 391619008650 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 391619008651 dimer interface [polypeptide binding]; other site 391619008652 active site 391619008653 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 391619008654 dimer interface [polypeptide binding]; other site 391619008655 active site 391619008656 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 391619008657 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391619008658 DNA-binding site [nucleotide binding]; DNA binding site 391619008659 UTRA domain; Region: UTRA; pfam07702 391619008660 Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971 391619008661 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 391619008662 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 391619008663 putative active site [active] 391619008664 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391619008665 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 391619008666 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391619008667 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619008668 dimer interface [polypeptide binding]; other site 391619008669 conserved gate region; other site 391619008670 putative PBP binding loops; other site 391619008671 ABC-ATPase subunit interface; other site 391619008672 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391619008673 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619008674 dimer interface [polypeptide binding]; other site 391619008675 conserved gate region; other site 391619008676 putative PBP binding loops; other site 391619008677 ABC-ATPase subunit interface; other site 391619008678 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 391619008679 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391619008680 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391619008681 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 391619008682 Walker A/P-loop; other site 391619008683 ATP binding site [chemical binding]; other site 391619008684 Q-loop/lid; other site 391619008685 ABC transporter signature motif; other site 391619008686 Walker B; other site 391619008687 D-loop; other site 391619008688 H-loop/switch region; other site 391619008689 TOBE domain; Region: TOBE_2; pfam08402 391619008690 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 391619008691 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 391619008692 active site 391619008693 dimer interface [polypeptide binding]; other site 391619008694 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 391619008695 dimer interface [polypeptide binding]; other site 391619008696 active site 391619008697 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 391619008698 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 391619008699 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 391619008700 phosphogluconate dehydratase; Validated; Region: PRK09054 391619008701 6-phosphogluconate dehydratase; Region: edd; TIGR01196 391619008702 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 391619008703 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 391619008704 active site 391619008705 intersubunit interface [polypeptide binding]; other site 391619008706 catalytic residue [active] 391619008707 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 391619008708 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 391619008709 putative substrate binding site [chemical binding]; other site 391619008710 putative ATP binding site [chemical binding]; other site 391619008711 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 391619008712 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 391619008713 active site 391619008714 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391619008715 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 391619008716 Walker A/P-loop; other site 391619008717 ATP binding site [chemical binding]; other site 391619008718 Q-loop/lid; other site 391619008719 ABC transporter signature motif; other site 391619008720 Walker B; other site 391619008721 D-loop; other site 391619008722 H-loop/switch region; other site 391619008723 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391619008724 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391619008725 TM-ABC transporter signature motif; other site 391619008726 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 391619008727 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 391619008728 ligand binding site [chemical binding]; other site 391619008729 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391619008730 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391619008731 putative DNA binding site [nucleotide binding]; other site 391619008732 putative Zn2+ binding site [ion binding]; other site 391619008733 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 391619008734 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 391619008735 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 391619008736 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391619008737 Coenzyme A binding pocket [chemical binding]; other site 391619008738 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 391619008739 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 391619008740 putative active site [active] 391619008741 putative PHP Thumb interface [polypeptide binding]; other site 391619008742 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 391619008743 generic binding surface II; other site 391619008744 generic binding surface I; other site 391619008745 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 391619008746 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391619008747 catalytic loop [active] 391619008748 iron binding site [ion binding]; other site 391619008749 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 391619008750 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 391619008751 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 391619008752 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 391619008753 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 391619008754 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 391619008755 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 391619008756 XdhC Rossmann domain; Region: XdhC_C; pfam13478 391619008757 ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845 391619008758 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 391619008759 Walker A/P-loop; other site 391619008760 ATP binding site [chemical binding]; other site 391619008761 Q-loop/lid; other site 391619008762 ABC transporter signature motif; other site 391619008763 Walker B; other site 391619008764 D-loop; other site 391619008765 H-loop/switch region; other site 391619008766 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 391619008767 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391619008768 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 391619008769 TM-ABC transporter signature motif; other site 391619008770 Protein of unknown function (DUF2834); Region: DUF2834; pfam11196 391619008771 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391619008772 Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580 391619008773 TM-ABC transporter signature motif; other site 391619008774 Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744 391619008775 Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353 391619008776 putative ligand binding site [chemical binding]; other site 391619008777 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 391619008778 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 391619008779 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 391619008780 active site 391619008781 catalytic tetrad [active] 391619008782 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391619008783 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391619008784 Methyltransferase domain; Region: Methyltransf_23; pfam13489 391619008785 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391619008786 S-adenosylmethionine binding site [chemical binding]; other site 391619008787 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391619008788 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391619008789 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 391619008790 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391619008791 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 391619008792 FAD binding domain; Region: FAD_binding_4; pfam01565 391619008793 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 391619008794 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 391619008795 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 391619008796 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 391619008797 dimerization interface [polypeptide binding]; other site 391619008798 ligand binding site [chemical binding]; other site 391619008799 NADP binding site [chemical binding]; other site 391619008800 catalytic site [active] 391619008801 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807 391619008802 Bacterial SH3 domain; Region: SH3_4; pfam06347 391619008803 Bacterial SH3 domain; Region: SH3_4; pfam06347 391619008804 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391619008805 AAA domain; Region: AAA_23; pfam13476 391619008806 Walker A/P-loop; other site 391619008807 ATP binding site [chemical binding]; other site 391619008808 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 391619008809 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 391619008810 active site 391619008811 metal binding site [ion binding]; metal-binding site 391619008812 DNA binding site [nucleotide binding] 391619008813 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 391619008814 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391619008815 DNA-binding site [nucleotide binding]; DNA binding site 391619008816 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 391619008817 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432 391619008818 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 391619008819 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 391619008820 Walker A/P-loop; other site 391619008821 ATP binding site [chemical binding]; other site 391619008822 Q-loop/lid; other site 391619008823 ABC transporter signature motif; other site 391619008824 Walker B; other site 391619008825 D-loop; other site 391619008826 H-loop/switch region; other site 391619008827 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 391619008828 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619008829 dimer interface [polypeptide binding]; other site 391619008830 conserved gate region; other site 391619008831 ABC-ATPase subunit interface; other site 391619008832 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 391619008833 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 391619008834 Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071 391619008835 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 391619008836 catalytic triad [active] 391619008837 Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224 391619008838 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 391619008839 Hemerythrin-like domain; Region: Hr-like; cd12108 391619008840 Fe binding site [ion binding]; other site 391619008841 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 391619008842 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391619008843 Walker A/P-loop; other site 391619008844 ATP binding site [chemical binding]; other site 391619008845 Q-loop/lid; other site 391619008846 ABC transporter signature motif; other site 391619008847 Walker B; other site 391619008848 D-loop; other site 391619008849 H-loop/switch region; other site 391619008850 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 391619008851 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391619008852 Walker A/P-loop; other site 391619008853 ATP binding site [chemical binding]; other site 391619008854 Q-loop/lid; other site 391619008855 ABC transporter signature motif; other site 391619008856 Walker B; other site 391619008857 D-loop; other site 391619008858 H-loop/switch region; other site 391619008859 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391619008860 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 391619008861 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619008862 dimer interface [polypeptide binding]; other site 391619008863 conserved gate region; other site 391619008864 ABC-ATPase subunit interface; other site 391619008865 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391619008866 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619008867 dimer interface [polypeptide binding]; other site 391619008868 conserved gate region; other site 391619008869 putative PBP binding loops; other site 391619008870 ABC-ATPase subunit interface; other site 391619008871 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 391619008872 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391619008873 non-specific DNA binding site [nucleotide binding]; other site 391619008874 salt bridge; other site 391619008875 sequence-specific DNA binding site [nucleotide binding]; other site 391619008876 Cupin domain; Region: Cupin_2; pfam07883 391619008877 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 391619008878 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 391619008879 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 391619008880 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 391619008881 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 391619008882 active site 391619008883 Response regulator receiver domain; Region: Response_reg; pfam00072 391619008884 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391619008885 active site 391619008886 phosphorylation site [posttranslational modification] 391619008887 intermolecular recognition site; other site 391619008888 dimerization interface [polypeptide binding]; other site 391619008889 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391619008890 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391619008891 substrate binding pocket [chemical binding]; other site 391619008892 membrane-bound complex binding site; other site 391619008893 hinge residues; other site 391619008894 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391619008895 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391619008896 substrate binding pocket [chemical binding]; other site 391619008897 membrane-bound complex binding site; other site 391619008898 hinge residues; other site 391619008899 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 391619008900 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391619008901 dimer interface [polypeptide binding]; other site 391619008902 phosphorylation site [posttranslational modification] 391619008903 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391619008904 ATP binding site [chemical binding]; other site 391619008905 Mg2+ binding site [ion binding]; other site 391619008906 G-X-G motif; other site 391619008907 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391619008908 active site 391619008909 phosphorylation site [posttranslational modification] 391619008910 intermolecular recognition site; other site 391619008911 Condensation domain; Region: Condensation; pfam00668 391619008912 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391619008913 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 391619008914 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 391619008915 acyl-activating enzyme (AAE) consensus motif; other site 391619008916 AMP binding site [chemical binding]; other site 391619008917 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 391619008918 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 391619008919 Transposase; Region: HTH_Tnp_1; cl17663 391619008920 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 391619008921 putative transposase OrfB; Reviewed; Region: PHA02517 391619008922 HTH-like domain; Region: HTH_21; pfam13276 391619008923 Integrase core domain; Region: rve; pfam00665 391619008924 Integrase core domain; Region: rve_3; pfam13683 391619008925 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 391619008926 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 391619008927 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 391619008928 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391619008929 NAD(P) binding site [chemical binding]; other site 391619008930 active site 391619008931 Putative zinc binding domain; Region: Methyltransf_13; pfam08421 391619008932 Methyltransferase domain; Region: Methyltransf_23; pfam13489 391619008933 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391619008934 S-adenosylmethionine binding site [chemical binding]; other site 391619008935 C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484 391619008936 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391619008937 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 391619008938 Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251 391619008939 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 391619008940 putative active site [active] 391619008941 heme pocket [chemical binding]; other site 391619008942 GAF domain; Region: GAF; pfam01590 391619008943 Phytochrome region; Region: PHY; pfam00360 391619008944 HWE histidine kinase; Region: HWE_HK; pfam07536 391619008945 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 391619008946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391619008947 active site 391619008948 phosphorylation site [posttranslational modification] 391619008949 intermolecular recognition site; other site 391619008950 reductive dehalogenase; Region: RDH; TIGR02486 391619008951 reductive dehalogenase; Region: RDH; TIGR02486 391619008952 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 391619008953 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 391619008954 FMN-binding pocket [chemical binding]; other site 391619008955 flavin binding motif; other site 391619008956 phosphate binding motif [ion binding]; other site 391619008957 beta-alpha-beta structure motif; other site 391619008958 NAD binding pocket [chemical binding]; other site 391619008959 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391619008960 catalytic loop [active] 391619008961 iron binding site [ion binding]; other site 391619008962 LamB/YcsF family of lactam utilization protein; Region: LamB_YcsF_like; cd10787 391619008963 putative active site [active] 391619008964 Allophanate hydrolase subunit 2; Region: AHS2; pfam02626 391619008965 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 391619008966 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 391619008967 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 391619008968 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 391619008969 putative active site [active] 391619008970 putative dimer interface [polypeptide binding]; other site 391619008971 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 391619008972 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391619008973 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391619008974 catalytic residue [active] 391619008975 hypothetical protein; Provisional; Region: PRK07483 391619008976 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 391619008977 inhibitor-cofactor binding pocket; inhibition site 391619008978 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391619008979 catalytic residue [active] 391619008980 Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827 391619008981 aminotransferase; Validated; Region: PRK07678 391619008982 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 391619008983 inhibitor-cofactor binding pocket; inhibition site 391619008984 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391619008985 catalytic residue [active] 391619008986 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 391619008987 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 391619008988 Predicted permease; Region: DUF318; cl17795 391619008989 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391619008990 dimerization interface [polypeptide binding]; other site 391619008991 putative DNA binding site [nucleotide binding]; other site 391619008992 putative Zn2+ binding site [ion binding]; other site 391619008993 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 391619008994 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391619008995 DNA-binding site [nucleotide binding]; DNA binding site 391619008996 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391619008997 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391619008998 homodimer interface [polypeptide binding]; other site 391619008999 catalytic residue [active] 391619009000 sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525 391619009001 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391619009002 PYR/PP interface [polypeptide binding]; other site 391619009003 dimer interface [polypeptide binding]; other site 391619009004 TPP binding site [chemical binding]; other site 391619009005 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 391619009006 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 391619009007 TPP-binding site [chemical binding]; other site 391619009008 Acetate kinase [Energy production and conversion]; Region: ackA; COG0282 391619009009 propionate/acetate kinase; Provisional; Region: PRK12379 391619009010 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 391619009011 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 391619009012 Citrate synthase; Region: Citrate_synt; pfam00285 391619009013 oxalacetate binding site [chemical binding]; other site 391619009014 citrylCoA binding site [chemical binding]; other site 391619009015 coenzyme A binding site [chemical binding]; other site 391619009016 catalytic triad [active] 391619009017 Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243 391619009018 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 391619009019 molybdopterin cofactor binding site; other site 391619009020 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 391619009021 The MopB_CT_2 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is...; Region: MopB_CT_2; cd02783 391619009022 putative molybdopterin cofactor binding site; other site 391619009023 Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437 391619009024 4Fe-4S binding domain; Region: Fer4; pfam00037 391619009025 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 391619009026 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 391619009027 Uncharacterized conserved protein [Function unknown]; Region: COG2128 391619009028 RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636 391619009029 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 391619009030 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 391619009031 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 391619009032 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 391619009033 dimer interface [polypeptide binding]; other site 391619009034 active site 391619009035 catalytic residue [active] 391619009036 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 391619009037 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 391619009038 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391619009039 catalytic residue [active] 391619009040 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391619009041 Uncharacterized conserved protein [Function unknown]; Region: COG4121 391619009042 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391619009043 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391619009044 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 391619009045 active site 391619009046 metal binding site [ion binding]; metal-binding site 391619009047 Predicted flavoprotein [General function prediction only]; Region: COG0431 391619009048 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 391619009049 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 391619009050 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 391619009051 ligand binding site [chemical binding]; other site 391619009052 Predicted transcriptional regulator [Transcription]; Region: COG2378 391619009053 HTH domain; Region: HTH_11; pfam08279 391619009054 WYL domain; Region: WYL; pfam13280 391619009055 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391619009056 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 391619009057 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 391619009058 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 391619009059 DNA binding site [nucleotide binding] 391619009060 active site 391619009061 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 391619009062 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 391619009063 minor groove reading motif; other site 391619009064 helix-hairpin-helix signature motif; other site 391619009065 substrate binding pocket [chemical binding]; other site 391619009066 active site 391619009067 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 391619009068 Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168 391619009069 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 391619009070 substrate binding site [chemical binding]; other site 391619009071 ATP binding site [chemical binding]; other site 391619009072 MarR family; Region: MarR_2; cl17246 391619009073 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 391619009074 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 391619009075 EamA-like transporter family; Region: EamA; pfam00892 391619009076 EamA-like transporter family; Region: EamA; pfam00892 391619009077 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 391619009078 putative active site [active] 391619009079 Ap4A binding site [chemical binding]; other site 391619009080 nudix motif; other site 391619009081 putative metal binding site [ion binding]; other site 391619009082 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 391619009083 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 391619009084 active site 391619009085 FMN binding site [chemical binding]; other site 391619009086 2,4-decadienoyl-CoA binding site; other site 391619009087 catalytic residue [active] 391619009088 4Fe-4S cluster binding site [ion binding]; other site 391619009089 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 391619009090 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391619009091 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391619009092 intracellular protease, PfpI family; Region: PfpI; TIGR01382 391619009093 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 391619009094 proposed catalytic triad [active] 391619009095 conserved cys residue [active] 391619009096 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 391619009097 NIPSNAP; Region: NIPSNAP; pfam07978 391619009098 Domain of unknown function (DUF4399); Region: DUF4399; pfam14347 391619009099 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391619009100 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391619009101 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 391619009102 putative effector binding pocket; other site 391619009103 dimerization interface [polypeptide binding]; other site 391619009104 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 391619009105 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 391619009106 ligand binding site [chemical binding]; other site 391619009107 PA26 p53-induced protein (sestrin); Region: PA26; pfam04636 391619009108 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 391619009109 Carboxymuconolactone decarboxylase family; Region: CMD; cl00460 391619009110 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 391619009111 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391619009112 Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058 391619009113 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 391619009114 putative MPT binding site; other site 391619009115 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 391619009116 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 391619009117 Mechanosensitive ion channel; Region: MS_channel; pfam00924 391619009118 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 391619009119 active site 391619009120 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 391619009121 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 391619009122 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391619009123 motif II; other site 391619009124 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 391619009125 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391619009126 S-adenosylmethionine binding site [chemical binding]; other site 391619009127 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 391619009128 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391619009129 Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013 391619009130 catalytic triad [active] 391619009131 dimer interface [polypeptide binding]; other site 391619009132 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914 391619009133 aromatic arch; other site 391619009134 DCoH dimer interaction site [polypeptide binding]; other site 391619009135 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 391619009136 DCoH tetramer interaction site [polypeptide binding]; other site 391619009137 substrate binding site [chemical binding]; other site 391619009138 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497 391619009139 Protein of unknown function, DUF482; Region: DUF482; pfam04339 391619009140 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 391619009141 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 391619009142 active site 391619009143 catalytic site [active] 391619009144 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 391619009145 homotrimer interaction site [polypeptide binding]; other site 391619009146 putative active site [active] 391619009147 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 391619009148 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 391619009149 HlyD family secretion protein; Region: HlyD_3; pfam13437 391619009150 ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618 391619009151 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391619009152 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 391619009153 Walker A/P-loop; other site 391619009154 ATP binding site [chemical binding]; other site 391619009155 Q-loop/lid; other site 391619009156 ABC transporter signature motif; other site 391619009157 Walker B; other site 391619009158 D-loop; other site 391619009159 H-loop/switch region; other site 391619009160 VacJ like lipoprotein; Region: VacJ; cl01073 391619009161 Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494 391619009162 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 391619009163 Transglycosylase; Region: Transgly; pfam00912 391619009164 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 391619009165 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 391619009166 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 391619009167 Nitrogen regulatory protein P-II; Region: P-II; smart00938 391619009168 probable ammonium transporter, marine subtype; Region: marine_trans_1; TIGR03644 391619009169 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 391619009170 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391619009171 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391619009172 homodimer interface [polypeptide binding]; other site 391619009173 catalytic residue [active] 391619009174 3-mercaptopyruvate sulfurtransferase; Region: PLN02723 391619009175 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 391619009176 active site residue [active] 391619009177 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 391619009178 active site residue [active] 391619009179 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 391619009180 SmpB-tmRNA interface; other site 391619009181 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 391619009182 EamA-like transporter family; Region: EamA; pfam00892 391619009183 EamA-like transporter family; Region: EamA; pfam00892 391619009184 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391619009185 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391619009186 non-specific DNA binding site [nucleotide binding]; other site 391619009187 salt bridge; other site 391619009188 sequence-specific DNA binding site [nucleotide binding]; other site 391619009189 Cupin domain; Region: Cupin_2; pfam07883 391619009190 benzoate transporter; Region: benE; TIGR00843 391619009191 Benzoate membrane transport protein; Region: BenE; pfam03594 391619009192 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 391619009193 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 391619009194 nudix motif; other site 391619009195 Sulfotransferase family; Region: Sulfotransfer_2; pfam03567 391619009196 Core-2/I-Branching enzyme; Region: Branch; pfam02485 391619009197 Protein of unknown function (DUF1523); Region: DUF1523; pfam07509 391619009198 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391619009199 Walker A motif; other site 391619009200 ATP binding site [chemical binding]; other site 391619009201 Walker B motif; other site 391619009202 arginine finger; other site 391619009203 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 391619009204 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391619009205 S-adenosylmethionine binding site [chemical binding]; other site 391619009206 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 391619009207 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 391619009208 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 391619009209 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 391619009210 Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea; Region: Creatinase; cd01090 391619009211 active site 391619009212 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391619009213 succinic semialdehyde dehydrogenase; Region: PLN02278 391619009214 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 391619009215 tetramerization interface [polypeptide binding]; other site 391619009216 NAD(P) binding site [chemical binding]; other site 391619009217 catalytic residues [active] 391619009218 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 391619009219 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 391619009220 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 391619009221 putative dimer interface [polypeptide binding]; other site 391619009222 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 391619009223 active site 391619009224 substrate binding sites [chemical binding]; other site 391619009225 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 391619009226 active site 391619009227 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 391619009228 Cysteine-rich domain; Region: CCG; pfam02754 391619009229 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 391619009230 FAD binding domain; Region: FAD_binding_4; pfam01565 391619009231 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 391619009232 FAD binding domain; Region: FAD_binding_4; pfam01565 391619009233 Protein of unknown function, DUF599; Region: DUF599; pfam04654 391619009234 rRNA large subunit methyltransferase; Provisional; Region: PRK00103 391619009235 iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090 391619009236 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 391619009237 Mechanosensitive ion channel; Region: MS_channel; pfam00924 391619009238 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 391619009239 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 391619009240 substrate binding site [chemical binding]; other site 391619009241 ligand binding site [chemical binding]; other site 391619009242 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 391619009243 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 391619009244 substrate binding site [chemical binding]; other site 391619009245 Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094 391619009246 tartrate dehydrogenase; Region: TTC; TIGR02089 391619009247 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 391619009248 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391619009249 EamA-like transporter family; Region: EamA; pfam00892 391619009250 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 391619009251 ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583 391619009252 ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295 391619009253 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 391619009254 motif 1; other site 391619009255 dimer interface [polypeptide binding]; other site 391619009256 active site 391619009257 motif 2; other site 391619009258 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 391619009259 motif 3; other site 391619009260 histidyl-tRNA synthetase; Region: hisS; TIGR00442 391619009261 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 391619009262 dimer interface [polypeptide binding]; other site 391619009263 motif 1; other site 391619009264 motif 2; other site 391619009265 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 391619009266 active site 391619009267 motif 3; other site 391619009268 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 391619009269 anticodon binding site; other site 391619009270 SlyX; Region: SlyX; pfam04102 391619009271 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 391619009272 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 391619009273 metal-binding site [ion binding] 391619009274 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 391619009275 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 391619009276 Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804 391619009277 CoA-transferase family III; Region: CoA_transf_3; pfam02515 391619009278 methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252 391619009279 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 391619009280 substrate binding site [chemical binding]; other site 391619009281 active site 391619009282 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 391619009283 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 391619009284 domain interfaces; other site 391619009285 active site 391619009286 Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413 391619009287 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 391619009288 active site 391619009289 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 391619009290 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 391619009291 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 391619009292 classical (c) SDRs; Region: SDR_c; cd05233 391619009293 NAD(P) binding site [chemical binding]; other site 391619009294 active site 391619009295 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 391619009296 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391619009297 S-adenosylmethionine binding site [chemical binding]; other site 391619009298 Uncharacterized conserved protein [Function unknown]; Region: COG2127 391619009299 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 391619009300 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 391619009301 motif II; other site 391619009302 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 391619009303 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 391619009304 Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597 391619009305 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 391619009306 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 391619009307 metal-binding site [ion binding] 391619009308 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 391619009309 Soluble P-type ATPase [General function prediction only]; Region: COG4087 391619009310 Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456 391619009311 FixH; Region: FixH; pfam05751 391619009312 cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745 391619009313 4Fe-4S binding domain; Region: Fer4_5; pfam12801 391619009314 4Fe-4S binding domain; Region: Fer4; cl02805 391619009315 Ubp3 associated protein Bre5; Region: Bre5; pfam11614 391619009316 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 391619009317 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 391619009318 cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782 391619009319 Cytochrome c; Region: Cytochrom_C; pfam00034 391619009320 Cytochrome c; Region: Cytochrom_C; pfam00034 391619009321 Cytochrome cbb oxidase CcoQ. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324 391619009322 Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993 391619009323 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433 391619009324 Cytochrome cbb3 oxidase subunit I. Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661 391619009325 Low-spin heme binding site [chemical binding]; other site 391619009326 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 391619009327 Putative water exit pathway; other site 391619009328 Binuclear center (active site) [active] 391619009329 Putative proton exit pathway; other site 391619009330 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 391619009331 Ligand Binding Site [chemical binding]; other site 391619009332 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 391619009333 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 391619009334 ligand binding site [chemical binding]; other site 391619009335 flexible hinge region; other site 391619009336 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 391619009337 putative switch regulator; other site 391619009338 non-specific DNA interactions [nucleotide binding]; other site 391619009339 DNA binding site [nucleotide binding] 391619009340 sequence specific DNA binding site [nucleotide binding]; other site 391619009341 putative cAMP binding site [chemical binding]; other site 391619009342 ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172 391619009343 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391619009344 Walker A/P-loop; other site 391619009345 ATP binding site [chemical binding]; other site 391619009346 Q-loop/lid; other site 391619009347 ABC transporter signature motif; other site 391619009348 Walker B; other site 391619009349 D-loop; other site 391619009350 H-loop/switch region; other site 391619009351 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 391619009352 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391619009353 Walker A/P-loop; other site 391619009354 ATP binding site [chemical binding]; other site 391619009355 Q-loop/lid; other site 391619009356 ABC transporter signature motif; other site 391619009357 Walker B; other site 391619009358 D-loop; other site 391619009359 H-loop/switch region; other site 391619009360 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391619009361 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 391619009362 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619009363 dimer interface [polypeptide binding]; other site 391619009364 conserved gate region; other site 391619009365 putative PBP binding loops; other site 391619009366 ABC-ATPase subunit interface; other site 391619009367 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 391619009368 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619009369 dimer interface [polypeptide binding]; other site 391619009370 conserved gate region; other site 391619009371 putative PBP binding loops; other site 391619009372 ABC-ATPase subunit interface; other site 391619009373 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 391619009374 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 391619009375 Cytochrome c2 [Energy production and conversion]; Region: COG3474 391619009376 prephenate dehydratase; Provisional; Region: PRK11899 391619009377 Prephenate dehydratase; Region: PDT; pfam00800 391619009378 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 391619009379 putative L-Phe binding site [chemical binding]; other site 391619009380 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 391619009381 hydrophobic ligand binding site; other site 391619009382 NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816 391619009383 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 391619009384 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 391619009385 putative NADH binding site [chemical binding]; other site 391619009386 putative active site [active] 391619009387 nudix motif; other site 391619009388 putative metal binding site [ion binding]; other site 391619009389 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 391619009390 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 391619009391 active site 391619009392 metal binding site [ion binding]; metal-binding site 391619009393 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 391619009394 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 391619009395 active site 391619009396 DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111 391619009397 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391619009398 Walker A motif; other site 391619009399 ATP binding site [chemical binding]; other site 391619009400 Walker B motif; other site 391619009401 arginine finger; other site 391619009402 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 391619009403 DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362 391619009404 hypothetical protein; Validated; Region: PRK00153 391619009405 recombination protein RecR; Reviewed; Region: recR; PRK00076 391619009406 RecR protein; Region: RecR; pfam02132 391619009407 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 391619009408 putative active site [active] 391619009409 putative metal-binding site [ion binding]; other site 391619009410 tetramer interface [polypeptide binding]; other site 391619009411 Protein of unknown function (DUF1013); Region: DUF1013; pfam06242 391619009412 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 391619009413 B1 nucleotide binding pocket [chemical binding]; other site 391619009414 B2 nucleotide binding pocket [chemical binding]; other site 391619009415 CAS motifs; other site 391619009416 active site 391619009417 Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291 391619009418 putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824 391619009419 PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276 391619009420 NAD(P) binding site [chemical binding]; other site 391619009421 rpsU-divergently transcribed protein; Region: diverge_rpsU; TIGR02396 391619009422 COQ9; Region: COQ9; pfam08511 391619009423 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 391619009424 polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707 391619009425 choline dehydrogenase; Validated; Region: PRK02106 391619009426 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391619009427 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 391619009428 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391619009429 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391619009430 putative DNA binding site [nucleotide binding]; other site 391619009431 putative Zn2+ binding site [ion binding]; other site 391619009432 AsnC family; Region: AsnC_trans_reg; pfam01037 391619009433 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 391619009434 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 391619009435 hexamer interface [polypeptide binding]; other site 391619009436 ligand binding site [chemical binding]; other site 391619009437 putative active site [active] 391619009438 NAD(P) binding site [chemical binding]; other site 391619009439 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391619009440 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391619009441 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 391619009442 Prostaglandin dehydrogenases; Region: PGDH; cd05288 391619009443 NAD(P) binding site [chemical binding]; other site 391619009444 substrate binding site [chemical binding]; other site 391619009445 dimer interface [polypeptide binding]; other site 391619009446 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 391619009447 Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141 391619009448 potential catalytic triad [active] 391619009449 conserved cys residue [active] 391619009450 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 391619009451 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 391619009452 homodimer interface [polypeptide binding]; other site 391619009453 substrate-cofactor binding pocket; other site 391619009454 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391619009455 catalytic residue [active] 391619009456 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 391619009457 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 391619009458 active site 391619009459 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 391619009460 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 391619009461 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391619009462 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391619009463 putative DNA binding site [nucleotide binding]; other site 391619009464 putative Zn2+ binding site [ion binding]; other site 391619009465 AsnC family; Region: AsnC_trans_reg; pfam01037 391619009466 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 391619009467 Helix-turn-helix domain; Region: HTH_18; pfam12833 391619009468 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391619009469 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 391619009470 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 391619009471 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 391619009472 Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724 391619009473 Transcriptional regulators [Transcription]; Region: GntR; COG1802 391619009474 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391619009475 DNA-binding site [nucleotide binding]; DNA binding site 391619009476 FCD domain; Region: FCD; pfam07729 391619009477 Protein of unknown function DUF45; Region: DUF45; pfam01863 391619009478 Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538 391619009479 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530 391619009480 Hint domain; Region: Hint_2; pfam13403 391619009481 Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022 391619009482 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391619009483 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 391619009484 DNA binding residues [nucleotide binding] 391619009485 Integrase core domain; Region: rve; pfam00665 391619009486 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 391619009487 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391619009488 Walker A motif; other site 391619009489 ATP binding site [chemical binding]; other site 391619009490 Walker B motif; other site 391619009491 arginine finger; other site 391619009492 HNH endonuclease; Region: HNH_2; pfam13391 391619009493 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391619009494 non-specific DNA binding site [nucleotide binding]; other site 391619009495 salt bridge; other site 391619009496 sequence-specific DNA binding site [nucleotide binding]; other site 391619009497 Protein of unknown function DUF45; Region: DUF45; pfam01863 391619009498 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 391619009499 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 391619009500 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391619009501 ATP binding site [chemical binding]; other site 391619009502 putative Mg++ binding site [ion binding]; other site 391619009503 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 391619009504 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 391619009505 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 391619009506 Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286 391619009507 HsdM N-terminal domain; Region: HsdM_N; pfam12161 391619009508 Methyltransferase domain; Region: Methyltransf_26; pfam13659 391619009509 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391619009510 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391619009511 non-specific DNA binding site [nucleotide binding]; other site 391619009512 salt bridge; other site 391619009513 sequence-specific DNA binding site [nucleotide binding]; other site 391619009514 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 391619009515 active site 391619009516 catalytic residues [active] 391619009517 DNA binding site [nucleotide binding] 391619009518 Int/Topo IB signature motif; other site 391619009519 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 391619009520 active site 391619009521 Int/Topo IB signature motif; other site 391619009522 DNA binding site [nucleotide binding] 391619009523 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 391619009524 active site 391619009525 catalytic site [active] 391619009526 substrate binding site [chemical binding]; other site 391619009527 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391619009528 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391619009529 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 391619009530 dimerization interface [polypeptide binding]; other site 391619009531 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 391619009532 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 391619009533 Walker A/P-loop; other site 391619009534 ATP binding site [chemical binding]; other site 391619009535 Q-loop/lid; other site 391619009536 ABC transporter signature motif; other site 391619009537 Walker B; other site 391619009538 D-loop; other site 391619009539 H-loop/switch region; other site 391619009540 TOBE domain; Region: TOBE_2; pfam08402 391619009541 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391619009542 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619009543 dimer interface [polypeptide binding]; other site 391619009544 conserved gate region; other site 391619009545 putative PBP binding loops; other site 391619009546 ABC-ATPase subunit interface; other site 391619009547 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 391619009548 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619009549 dimer interface [polypeptide binding]; other site 391619009550 conserved gate region; other site 391619009551 putative PBP binding loops; other site 391619009552 ABC-ATPase subunit interface; other site 391619009553 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 391619009554 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 391619009555 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 391619009556 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 391619009557 active site 391619009558 metal binding site [ion binding]; metal-binding site 391619009559 hexamer interface [polypeptide binding]; other site 391619009560 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 391619009561 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 391619009562 active site 391619009563 metal binding site [ion binding]; metal-binding site 391619009564 hexamer interface [polypeptide binding]; other site 391619009565 HipA N-terminal domain; Region: Couple_hipA; cl11853 391619009566 HipA-like C-terminal domain; Region: HipA_C; pfam07804 391619009567 Protein of unknown function (DUF433); Region: DUF433; pfam04255 391619009568 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 391619009569 HSP70 interaction site [polypeptide binding]; other site 391619009570 Domain of unknown function (DUF955); Region: DUF955; cl01076 391619009571 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 391619009572 Part of AAA domain; Region: AAA_19; pfam13245 391619009573 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 391619009574 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 391619009575 Bacterial multiubiquitin; Region: Bac_multiUb; pfam14452 391619009576 Prokaryotic E2 family E; Region: Prok-E2_E; pfam14462 391619009577 Prokaryotic homologs of the JAB domain; Region: Prok-JAB; pfam14464 391619009578 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 391619009579 Superfamily of activating enzymes (E1) of the ubiquitin-like proteins. This family includes classical ubiquitin-activating enzymes E1, ubiquitin-like (ubl) activating enzymes and other mechanistic homologes, like MoeB, Thif1 and others. The common...; Region: E1_enzyme_family; cd01483 391619009580 ATP binding site [chemical binding]; other site 391619009581 substrate interface [chemical binding]; other site 391619009582 Domain of unknown function (DUF329); Region: DUF329; pfam03884 391619009583 Ribonuclease E/G family; Region: RNase_E_G; pfam10150 391619009584 Maf-like protein; Region: Maf; pfam02545 391619009585 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 391619009586 active site 391619009587 dimer interface [polypeptide binding]; other site 391619009588 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 391619009589 rRNA binding site [nucleotide binding]; other site 391619009590 predicted 30S ribosome binding site; other site 391619009591 Predicted amidohydrolase [General function prediction only]; Region: COG0388 391619009592 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 391619009593 putative active site [active] 391619009594 catalytic triad [active] 391619009595 putative dimer interface [polypeptide binding]; other site 391619009596 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 391619009597 Coenzyme A binding pocket [chemical binding]; other site 391619009598 Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109 391619009599 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 391619009600 Low molecular weight phosphatase family; Region: LMWPc; cl00105 391619009601 active site 391619009602 hypothetical protein; Provisional; Region: PRK02853 391619009603 Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141 391619009604 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 391619009605 NAD binding site [chemical binding]; other site 391619009606 dimerization interface [polypeptide binding]; other site 391619009607 product binding site; other site 391619009608 substrate binding site [chemical binding]; other site 391619009609 zinc binding site [ion binding]; other site 391619009610 catalytic residues [active] 391619009611 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 391619009612 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 391619009613 Coenzyme A binding pocket [chemical binding]; other site 391619009614 Protein of unknown function (DUF2948); Region: DUF2948; pfam11164 391619009615 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 391619009616 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 391619009617 hinge; other site 391619009618 active site 391619009619 Protein of unknown function (DUF3131); Region: DUF3131; pfam11329 391619009620 The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods. Chitinases have...; Region: GH18_chitinase-like; cl10447 391619009621 active site 391619009622 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 391619009623 Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962 391619009624 NodB motif; other site 391619009625 putative active site [active] 391619009626 putative catalytic site [active] 391619009627 putative Zn binding site [ion binding]; other site 391619009628 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 391619009629 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 391619009630 DXD motif; other site 391619009631 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391619009632 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619009633 dimer interface [polypeptide binding]; other site 391619009634 conserved gate region; other site 391619009635 putative PBP binding loops; other site 391619009636 ABC-ATPase subunit interface; other site 391619009637 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619009638 dimer interface [polypeptide binding]; other site 391619009639 conserved gate region; other site 391619009640 putative PBP binding loops; other site 391619009641 ABC-ATPase subunit interface; other site 391619009642 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391619009643 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391619009644 Walker A/P-loop; other site 391619009645 ATP binding site [chemical binding]; other site 391619009646 Q-loop/lid; other site 391619009647 ABC transporter signature motif; other site 391619009648 Walker B; other site 391619009649 D-loop; other site 391619009650 H-loop/switch region; other site 391619009651 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 391619009652 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 391619009653 phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340 391619009654 Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910 391619009655 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 391619009656 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 391619009657 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 391619009658 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 391619009659 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391619009660 DNA-binding site [nucleotide binding]; DNA binding site 391619009661 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 391619009662 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 391619009663 Sulfatase; Region: Sulfatase; cl17466 391619009664 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 391619009665 Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379 391619009666 MOFRL family; Region: MOFRL; pfam05161 391619009667 MarR family; Region: MarR_2; cl17246 391619009668 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 391619009669 tyrosine decarboxylase; Region: PLN02880 391619009670 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 391619009671 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391619009672 catalytic residue [active] 391619009673 2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836 391619009674 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 391619009675 Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328 391619009676 putative ligand binding site [chemical binding]; other site 391619009677 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391619009678 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 391619009679 Walker A/P-loop; other site 391619009680 ATP binding site [chemical binding]; other site 391619009681 Q-loop/lid; other site 391619009682 ABC transporter signature motif; other site 391619009683 Walker B; other site 391619009684 D-loop; other site 391619009685 H-loop/switch region; other site 391619009686 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391619009687 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 391619009688 Walker A/P-loop; other site 391619009689 ATP binding site [chemical binding]; other site 391619009690 Q-loop/lid; other site 391619009691 ABC transporter signature motif; other site 391619009692 Walker B; other site 391619009693 D-loop; other site 391619009694 H-loop/switch region; other site 391619009695 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391619009696 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391619009697 TM-ABC transporter signature motif; other site 391619009698 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 391619009699 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391619009700 TM-ABC transporter signature motif; other site 391619009701 N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600 391619009702 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 391619009703 aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874 391619009704 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 391619009705 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391619009706 putative substrate translocation pore; other site 391619009707 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 391619009708 Protein of unknown function (DUF3095); Region: DUF3095; pfam11294 391619009709 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 391619009710 active site clefts [active] 391619009711 zinc binding site [ion binding]; other site 391619009712 dimer interface [polypeptide binding]; other site 391619009713 Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260 391619009714 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 391619009715 interface (dimer of trimers) [polypeptide binding]; other site 391619009716 Substrate-binding/catalytic site; other site 391619009717 Zn-binding sites [ion binding]; other site 391619009718 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 391619009719 NlpC/P60 family; Region: NLPC_P60; pfam00877 391619009720 Protein of unknown function (DUF2794); Region: DUF2794; pfam10984 391619009721 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391619009722 dimerization interface [polypeptide binding]; other site 391619009723 putative DNA binding site [nucleotide binding]; other site 391619009724 putative Zn2+ binding site [ion binding]; other site 391619009725 Cytochrome C' Region: Cytochrom_C_2; cl01610 391619009726 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391619009727 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391619009728 AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246 391619009729 Predicted permeases [General function prediction only]; Region: COG0679 391619009730 S-formylglutathione hydrolase; Region: PLN02442 391619009731 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 391619009732 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 391619009733 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391619009734 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 391619009735 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 391619009736 Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639 391619009737 EamA-like transporter family; Region: EamA; pfam00892 391619009738 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391619009739 EamA-like transporter family; Region: EamA; cl17759 391619009740 Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419 391619009741 ?-D-glucose-1-phosphatase; Provisional; Region: PRK09456 391619009742 ornithine cyclodeaminase; Validated; Region: PRK06141 391619009743 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 391619009744 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391619009745 Major Facilitator Superfamily; Region: MFS_1; pfam07690 391619009746 putative substrate translocation pore; other site 391619009747 Predicted ATPase [General function prediction only]; Region: COG1485 391619009748 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 391619009749 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 391619009750 RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717 391619009751 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 391619009752 CAAX protease self-immunity; Region: Abi; pfam02517 391619009753 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 391619009754 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391619009755 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 391619009756 Walker A/P-loop; other site 391619009757 ATP binding site [chemical binding]; other site 391619009758 Q-loop/lid; other site 391619009759 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 391619009760 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391619009761 ABC transporter signature motif; other site 391619009762 Walker B; other site 391619009763 D-loop; other site 391619009764 H-loop/switch region; other site 391619009765 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 391619009766 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 391619009767 ligand binding site [chemical binding]; other site 391619009768 flexible hinge region; other site 391619009769 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 391619009770 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391619009771 Walker A/P-loop; other site 391619009772 ATP binding site [chemical binding]; other site 391619009773 Q-loop/lid; other site 391619009774 ABC transporter signature motif; other site 391619009775 Walker B; other site 391619009776 D-loop; other site 391619009777 H-loop/switch region; other site 391619009778 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391619009779 Zinc-finger domain; Region: zf-CHCC; pfam10276 391619009780 MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300 391619009781 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 391619009782 Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707 391619009783 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 391619009784 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 391619009785 metal binding site [ion binding]; metal-binding site 391619009786 active site 391619009787 I-site; other site 391619009788 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 391619009789 DNA polymerase I; Provisional; Region: PRK05755 391619009790 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 391619009791 active site 391619009792 metal binding site 1 [ion binding]; metal-binding site 391619009793 putative 5' ssDNA interaction site; other site 391619009794 metal binding site 3; metal-binding site 391619009795 metal binding site 2 [ion binding]; metal-binding site 391619009796 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 391619009797 putative DNA binding site [nucleotide binding]; other site 391619009798 putative metal binding site [ion binding]; other site 391619009799 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 391619009800 active site 391619009801 catalytic site [active] 391619009802 substrate binding site [chemical binding]; other site 391619009803 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 391619009804 active site 391619009805 DNA binding site [nucleotide binding] 391619009806 catalytic site [active] 391619009807 Protein of unknown function (DUF2798); Region: DUF2798; pfam11391 391619009808 Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622 391619009809 Protein of unknown function (DUF1285); Region: DUF1285; pfam06938 391619009810 MoxR-like ATPases [General function prediction only]; Region: COG0714 391619009811 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 391619009812 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 391619009813 Protein of unknown function DUF58; Region: DUF58; pfam01882 391619009814 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 391619009815 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 391619009816 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 391619009817 Transglycosylase; Region: Transgly; pfam00912 391619009818 penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074 391619009819 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 391619009820 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 391619009821 Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; Region: APPLE_Factor_XI_like; cd01100 391619009822 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 391619009823 MG2 domain; Region: A2M_N; pfam01835 391619009824 Alpha-2-macroglobulin family; Region: A2M; pfam00207 391619009825 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 391619009826 surface patch; other site 391619009827 thioester region; other site 391619009828 specificity defining residues; other site 391619009829 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391619009830 dimer interface [polypeptide binding]; other site 391619009831 phosphorylation site [posttranslational modification] 391619009832 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391619009833 ATP binding site [chemical binding]; other site 391619009834 Mg2+ binding site [ion binding]; other site 391619009835 G-X-G motif; other site 391619009836 Response regulator receiver domain; Region: Response_reg; pfam00072 391619009837 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391619009838 active site 391619009839 phosphorylation site [posttranslational modification] 391619009840 intermolecular recognition site; other site 391619009841 dimerization interface [polypeptide binding]; other site 391619009842 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 391619009843 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391619009844 active site 391619009845 phosphorylation site [posttranslational modification] 391619009846 intermolecular recognition site; other site 391619009847 dimerization interface [polypeptide binding]; other site 391619009848 hypothetical protein; Validated; Region: PRK02101 391619009849 ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389 391619009850 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 391619009851 ATP binding site [chemical binding]; other site 391619009852 putative Mg++ binding site [ion binding]; other site 391619009853 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 391619009854 nucleotide binding region [chemical binding]; other site 391619009855 ATP-binding site [chemical binding]; other site 391619009856 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 391619009857 HRDC domain; Region: HRDC; pfam00570 391619009858 YGGT family; Region: YGGT; pfam02325 391619009859 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 391619009860 active site 391619009861 Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270 391619009862 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391619009863 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 391619009864 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246 391619009865 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 391619009866 Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756 391619009867 hypothetical protein; Provisional; Region: PRK09256 391619009868 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 391619009869 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345 391619009870 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 391619009871 putative NAD(P) binding site [chemical binding]; other site 391619009872 active site 391619009873 nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252 391619009874 putative active site pocket [active] 391619009875 cleavage site 391619009876 Cytochrome c; Region: Cytochrom_C; cl11414 391619009877 isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150 391619009878 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 391619009879 active site 391619009880 metal binding site [ion binding]; metal-binding site 391619009881 nudix motif; other site 391619009882 hypothetical protein; Provisional; Region: PRK07538 391619009883 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 391619009884 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 391619009885 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 391619009886 N- and C-terminal domain interface [polypeptide binding]; other site 391619009887 active site 391619009888 MgATP binding site [chemical binding]; other site 391619009889 catalytic site [active] 391619009890 metal binding site [ion binding]; metal-binding site 391619009891 glycerol binding site [chemical binding]; other site 391619009892 homotetramer interface [polypeptide binding]; other site 391619009893 homodimer interface [polypeptide binding]; other site 391619009894 FBP binding site [chemical binding]; other site 391619009895 protein IIAGlc interface [polypeptide binding]; other site 391619009896 pantoate--beta-alanine ligase; Region: panC; TIGR00018 391619009897 Pantoate-beta-alanine ligase; Region: PanC; cd00560 391619009898 active site 391619009899 ATP-binding site [chemical binding]; other site 391619009900 pantoate-binding site; other site 391619009901 HXXH motif; other site 391619009902 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 391619009903 active site 391619009904 oligomerization interface [polypeptide binding]; other site 391619009905 metal binding site [ion binding]; metal-binding site 391619009906 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391619009907 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494 391619009908 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 391619009909 Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994 391619009910 active site 391619009911 Zn binding site [ion binding]; other site 391619009912 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391619009913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619009914 dimer interface [polypeptide binding]; other site 391619009915 conserved gate region; other site 391619009916 putative PBP binding loops; other site 391619009917 ABC-ATPase subunit interface; other site 391619009918 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 391619009919 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619009920 dimer interface [polypeptide binding]; other site 391619009921 ABC-ATPase subunit interface; other site 391619009922 putative PBP binding loops; other site 391619009923 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 391619009924 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391619009925 Walker A/P-loop; other site 391619009926 ATP binding site [chemical binding]; other site 391619009927 Q-loop/lid; other site 391619009928 ABC transporter signature motif; other site 391619009929 Walker B; other site 391619009930 D-loop; other site 391619009931 H-loop/switch region; other site 391619009932 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391619009933 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391619009934 Walker A/P-loop; other site 391619009935 ATP binding site [chemical binding]; other site 391619009936 Q-loop/lid; other site 391619009937 ABC transporter signature motif; other site 391619009938 Walker B; other site 391619009939 D-loop; other site 391619009940 H-loop/switch region; other site 391619009941 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391619009942 Predicted acetyltransferase [General function prediction only]; Region: COG5628 391619009943 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391619009944 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 391619009945 NAD(P) binding site [chemical binding]; other site 391619009946 catalytic residues [active] 391619009947 catalytic residues [active] 391619009948 Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488 391619009949 nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321 391619009950 active site 391619009951 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 391619009952 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 391619009953 putative active site [active] 391619009954 heme pocket [chemical binding]; other site 391619009955 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391619009956 dimer interface [polypeptide binding]; other site 391619009957 phosphorylation site [posttranslational modification] 391619009958 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391619009959 ATP binding site [chemical binding]; other site 391619009960 Mg2+ binding site [ion binding]; other site 391619009961 G-X-G motif; other site 391619009962 Response regulator receiver domain; Region: Response_reg; pfam00072 391619009963 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391619009964 active site 391619009965 phosphorylation site [posttranslational modification] 391619009966 intermolecular recognition site; other site 391619009967 dimerization interface [polypeptide binding]; other site 391619009968 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 391619009969 Isochorismatase family; Region: Isochorismatase; pfam00857 391619009970 catalytic triad [active] 391619009971 metal binding site [ion binding]; metal-binding site 391619009972 conserved cis-peptide bond; other site 391619009973 Predicted sulfurtransferase [General function prediction only]; Region: COG1054 391619009974 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 391619009975 active site residue [active] 391619009976 Hint domain; Region: Hint_2; pfam13403 391619009977 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421 391619009978 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 391619009979 NHAD transporter family protein; Provisional; Region: PLN00137; cl17324 391619009980 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 391619009981 3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295 391619009982 N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266 391619009983 tetramer interface [polypeptide binding]; other site 391619009984 C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256 391619009985 tetramer interface [polypeptide binding]; other site 391619009986 active site 391619009987 metal binding site [ion binding]; metal-binding site 391619009988 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 391619009989 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 391619009990 NAD binding site [chemical binding]; other site 391619009991 catalytic residues [active] 391619009992 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 391619009993 putative substrate binding pocket [chemical binding]; other site 391619009994 trimer interface [polypeptide binding]; other site 391619009995 hypothetical protein; Provisional; Region: PRK02399 391619009996 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 391619009997 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391619009998 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 391619009999 NAD(P) binding site [chemical binding]; other site 391619010000 catalytic residues [active] 391619010001 Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970 391619010002 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 391619010003 Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792 391619010004 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 391619010005 Transcriptional regulator [Transcription]; Region: IclR; COG1414 391619010006 Bacterial transcriptional regulator; Region: IclR; pfam01614 391619010007 hypothetical protein; Provisional; Region: PRK07481 391619010008 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 391619010009 inhibitor-cofactor binding pocket; inhibition site 391619010010 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391619010011 catalytic residue [active] 391619010012 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 391619010013 TMAO/DMSO reductase; Reviewed; Region: PRK05363 391619010014 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 391619010015 Moco binding site; other site 391619010016 metal coordination site [ion binding]; other site 391619010017 Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069 391619010018 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 391619010019 active site 391619010020 FMN binding site [chemical binding]; other site 391619010021 substrate binding site [chemical binding]; other site 391619010022 3Fe-4S cluster binding site [ion binding]; other site 391619010023 Domain of unknown function DUF302; Region: DUF302; cl01364 391619010024 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 391619010025 Clp amino terminal domain; Region: Clp_N; pfam02861 391619010026 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391619010027 Walker A motif; other site 391619010028 ATP binding site [chemical binding]; other site 391619010029 Walker B motif; other site 391619010030 arginine finger; other site 391619010031 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391619010032 Walker A motif; other site 391619010033 ATP binding site [chemical binding]; other site 391619010034 Walker B motif; other site 391619010035 arginine finger; other site 391619010036 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 391619010037 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 391619010038 active site 391619010039 dimer interface [polypeptide binding]; other site 391619010040 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682 391619010041 nudix motif; other site 391619010042 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 391619010043 active site 391619010044 DNA polymerase IV; Validated; Region: PRK02406 391619010045 DNA binding site [nucleotide binding] 391619010046 N-formylglutamate amidohydrolase; Region: FGase; pfam05013 391619010047 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 391619010048 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 391619010049 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 391619010050 Protein of unknown function (DUF2938); Region: DUF2938; pfam11158 391619010051 cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475 391619010052 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 391619010053 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 391619010054 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 391619010055 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619010056 dimer interface [polypeptide binding]; other site 391619010057 conserved gate region; other site 391619010058 putative PBP binding loops; other site 391619010059 ABC-ATPase subunit interface; other site 391619010060 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619010061 dimer interface [polypeptide binding]; other site 391619010062 conserved gate region; other site 391619010063 putative PBP binding loops; other site 391619010064 ABC-ATPase subunit interface; other site 391619010065 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391619010066 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 391619010067 acyl-activating enzyme (AAE) consensus motif; other site 391619010068 active site 391619010069 AMP binding site [chemical binding]; other site 391619010070 CoA binding site [chemical binding]; other site 391619010071 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 391619010072 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 391619010073 Walker A/P-loop; other site 391619010074 ATP binding site [chemical binding]; other site 391619010075 Q-loop/lid; other site 391619010076 ABC transporter signature motif; other site 391619010077 Walker B; other site 391619010078 D-loop; other site 391619010079 H-loop/switch region; other site 391619010080 Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334 391619010081 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 391619010082 putative ligand binding site [chemical binding]; other site 391619010083 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 391619010084 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 391619010085 TM-ABC transporter signature motif; other site 391619010086 Short C-terminal domain; Region: SHOCT; pfam09851 391619010087 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391619010088 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 391619010089 TM-ABC transporter signature motif; other site 391619010090 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391619010091 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 391619010092 Walker A/P-loop; other site 391619010093 ATP binding site [chemical binding]; other site 391619010094 Q-loop/lid; other site 391619010095 ABC transporter signature motif; other site 391619010096 Walker B; other site 391619010097 D-loop; other site 391619010098 H-loop/switch region; other site 391619010099 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 391619010100 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 391619010101 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 391619010102 acyl-activating enzyme (AAE) consensus motif; other site 391619010103 putative AMP binding site [chemical binding]; other site 391619010104 putative active site [active] 391619010105 putative CoA binding site [chemical binding]; other site 391619010106 PAS fold; Region: PAS_7; pfam12860 391619010107 PAS fold; Region: PAS_4; pfam08448 391619010108 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391619010109 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 391619010110 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391619010111 ATP binding site [chemical binding]; other site 391619010112 Mg2+ binding site [ion binding]; other site 391619010113 G-X-G motif; other site 391619010114 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391619010115 Response regulator receiver domain; Region: Response_reg; pfam00072 391619010116 active site 391619010117 phosphorylation site [posttranslational modification] 391619010118 intermolecular recognition site; other site 391619010119 dimerization interface [polypeptide binding]; other site 391619010120 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391619010121 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391619010122 active site 391619010123 phosphorylation site [posttranslational modification] 391619010124 intermolecular recognition site; other site 391619010125 dimerization interface [polypeptide binding]; other site 391619010126 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391619010127 DNA binding site [nucleotide binding] 391619010128 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 391619010129 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 391619010130 catalytic core [active] 391619010131 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 391619010132 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 391619010133 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 391619010134 C-terminal domain interface [polypeptide binding]; other site 391619010135 GSH binding site (G-site) [chemical binding]; other site 391619010136 dimer interface [polypeptide binding]; other site 391619010137 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 391619010138 dimer interface [polypeptide binding]; other site 391619010139 substrate binding pocket (H-site) [chemical binding]; other site 391619010140 N-terminal domain interface [polypeptide binding]; other site 391619010141 Saccharopine Dehydrogenase NAD-binding and catalytic domains; Region: SDH; cd12188 391619010142 active site 391619010143 ligand binding site [chemical binding]; other site 391619010144 homodimer interface [polypeptide binding]; other site 391619010145 NAD(P) binding site [chemical binding]; other site 391619010146 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 391619010147 Saccharopine dehydrogenase; Region: Saccharop_dh; pfam03435 391619010148 Protein of unknown function (DUF3775); Region: DUF3775; pfam12616 391619010149 cyclase homology domain; Region: CHD; cd07302 391619010150 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 391619010151 nucleotidyl binding site; other site 391619010152 metal binding site [ion binding]; metal-binding site 391619010153 dimer interface [polypeptide binding]; other site 391619010154 RmuC family; Region: RmuC; pfam02646 391619010155 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 391619010156 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391619010157 ATP binding site [chemical binding]; other site 391619010158 Mg2+ binding site [ion binding]; other site 391619010159 G-X-G motif; other site 391619010160 DNA mismatch repair protein, C-terminal domain; Region: DNA_mis_repair; pfam01119 391619010161 ATP binding site [chemical binding]; other site 391619010162 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 391619010163 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 391619010164 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 391619010165 ABC-ATPase subunit interface; other site 391619010166 dimer interface [polypeptide binding]; other site 391619010167 putative PBP binding regions; other site 391619010168 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 391619010169 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 391619010170 ABC-ATPase subunit interface; other site 391619010171 dimer interface [polypeptide binding]; other site 391619010172 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 391619010173 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 391619010174 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 391619010175 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 391619010176 intersubunit interface [polypeptide binding]; other site 391619010177 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 391619010178 intersubunit interface [polypeptide binding]; other site 391619010179 active site 391619010180 catalytic residue [active] 391619010181 Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111 391619010182 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391619010183 NAD(P) binding site [chemical binding]; other site 391619010184 catalytic residues [active] 391619010185 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 391619010186 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 391619010187 NAD(P) binding site [chemical binding]; other site 391619010188 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 391619010189 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 391619010190 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 391619010191 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 391619010192 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 391619010193 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 391619010194 Protein of unknown function (DUF3035); Region: DUF3035; pfam11233 391619010195 Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458 391619010196 lipoprotein signal peptidase; Provisional; Region: PRK14787 391619010197 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 391619010198 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 391619010199 purine monophosphate binding site [chemical binding]; other site 391619010200 dimer interface [polypeptide binding]; other site 391619010201 putative catalytic residues [active] 391619010202 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 391619010203 Heparinase II/III-like protein; Region: Hepar_II_III; cl15421 391619010204 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cd00447 391619010205 putative RNA binding site [nucleotide binding]; other site 391619010206 16S rRNA methyltransferase B; Provisional; Region: PRK10901 391619010207 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391619010208 S-adenosylmethionine binding site [chemical binding]; other site 391619010209 Uncharacterized conserved small protein [Function unknown]; Region: COG5508 391619010210 Protein of unknown function (DUF1674); Region: DUF1674; pfam07896 391619010211 Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992 391619010212 dihydrodipicolinate reductase; Provisional; Region: PRK00048 391619010213 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 391619010214 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 391619010215 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 391619010216 Predicted periplasmic protein [Function unknown]; Region: COG3698 391619010217 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 391619010218 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389 391619010219 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 391619010220 RNA binding site [nucleotide binding]; other site 391619010221 active site 391619010222 Protein of unknown function (DUF1643); Region: DUF1643; pfam07799 391619010223 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 391619010224 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 391619010225 16S/18S rRNA binding site [nucleotide binding]; other site 391619010226 S13e-L30e interaction site [polypeptide binding]; other site 391619010227 25S rRNA binding site [nucleotide binding]; other site 391619010228 Methyltransferase domain; Region: Methyltransf_31; pfam13847 391619010229 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391619010230 S-adenosylmethionine binding site [chemical binding]; other site 391619010231 Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119 391619010232 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 391619010233 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 391619010234 RNase E interface [polypeptide binding]; other site 391619010235 trimer interface [polypeptide binding]; other site 391619010236 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 391619010237 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 391619010238 RNase E interface [polypeptide binding]; other site 391619010239 trimer interface [polypeptide binding]; other site 391619010240 active site 391619010241 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 391619010242 putative nucleic acid binding region [nucleotide binding]; other site 391619010243 G-X-X-G motif; other site 391619010244 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 391619010245 RNA binding site [nucleotide binding]; other site 391619010246 domain interface; other site 391619010247 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 391619010248 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 391619010249 Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016 391619010250 dimer interface [polypeptide binding]; other site 391619010251 decamer (pentamer of dimers) interface [polypeptide binding]; other site 391619010252 catalytic triad [active] 391619010253 Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138 391619010254 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391619010255 NAD binding site [chemical binding]; other site 391619010256 catalytic residues [active] 391619010257 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 391619010258 active site 391619010259 metal binding site [ion binding]; metal-binding site 391619010260 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 391619010261 Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301 391619010262 GDP-Fucose binding site [chemical binding]; other site 391619010263 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 391619010264 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 391619010265 active site 391619010266 SnoaL-like domain; Region: SnoaL_2; pfam12680 391619010267 SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836 391619010268 active site 391619010269 catalytic triad [active] 391619010270 oxyanion hole [active] 391619010271 Predicted permeases [General function prediction only]; Region: RarD; COG2962 391619010272 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391619010273 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391619010274 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 391619010275 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 391619010276 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391619010277 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 391619010278 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 391619010279 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391619010280 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391619010281 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391619010282 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 391619010283 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391619010284 Uncharacterized conserved protein [Function unknown]; Region: COG3791 391619010285 Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280 391619010286 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391619010287 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391619010288 non-specific DNA binding site [nucleotide binding]; other site 391619010289 salt bridge; other site 391619010290 sequence-specific DNA binding site [nucleotide binding]; other site 391619010291 Cupin domain; Region: Cupin_2; pfam07883 391619010292 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 391619010293 acetyl-CoA acetyltransferase; Provisional; Region: PRK06954 391619010294 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 391619010295 dimer interface [polypeptide binding]; other site 391619010296 active site 391619010297 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 391619010298 anti sigma factor interaction site; other site 391619010299 regulatory phosphorylation site [posttranslational modification]; other site 391619010300 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 391619010301 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 391619010302 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 391619010303 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 391619010304 Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755 391619010305 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 391619010306 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 391619010307 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 391619010308 Uncharacterized conserved protein [Function unknown]; Region: COG2835 391619010309 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 391619010310 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 391619010311 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 391619010312 Amidase; Region: Amidase; cl11426 391619010313 succinyldiaminopimelate transaminase; Provisional; Region: PRK09147 391619010314 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391619010315 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391619010316 homodimer interface [polypeptide binding]; other site 391619010317 catalytic residue [active] 391619010318 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 391619010319 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 391619010320 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 391619010321 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 391619010322 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 391619010323 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 391619010324 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 391619010325 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391619010326 catalytic residue [active] 391619010327 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 391619010328 putative catalytic site [active] 391619010329 putative phosphate binding site [ion binding]; other site 391619010330 active site 391619010331 metal binding site A [ion binding]; metal-binding site 391619010332 DNA binding site [nucleotide binding] 391619010333 putative AP binding site [nucleotide binding]; other site 391619010334 putative metal binding site B [ion binding]; other site 391619010335 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 391619010336 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391619010337 active site 391619010338 phosphorylation site [posttranslational modification] 391619010339 intermolecular recognition site; other site 391619010340 dimerization interface [polypeptide binding]; other site 391619010341 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391619010342 DNA binding site [nucleotide binding] 391619010343 GTP cyclohydrolase; Provisional; Region: PRK08815 391619010344 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 391619010345 dimerization interface [polypeptide binding]; other site 391619010346 active site 391619010347 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786 391619010348 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 391619010349 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 391619010350 catalytic residue [active] 391619010351 Gram-negative porin; Region: Porin_4; pfam13609 391619010352 Domain of unknown function (DUF3576); Region: DUF3576; pfam12100 391619010353 Leucyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: LeuS; COG0495 391619010354 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 391619010355 HIGH motif; other site 391619010356 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 391619010357 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391619010358 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 391619010359 active site 391619010360 KMSKS motif; other site 391619010361 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 391619010362 tRNA binding surface [nucleotide binding]; other site 391619010363 Lipopolysaccharide-assembly; Region: LptE; pfam04390 391619010364 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585 391619010365 GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046 391619010366 putative C-terminal domain interface [polypeptide binding]; other site 391619010367 putative GSH binding site (G-site) [chemical binding]; other site 391619010368 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 391619010369 putative dimer interface [polypeptide binding]; other site 391619010370 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 391619010371 N-terminal domain interface [polypeptide binding]; other site 391619010372 substrate binding pocket (H-site) [chemical binding]; other site 391619010373 uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862 391619010374 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391619010375 substrate binding site [chemical binding]; other site 391619010376 oxyanion hole (OAH) forming residues; other site 391619010377 trimer interface [polypeptide binding]; other site 391619010378 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 391619010379 classical (c) SDRs; Region: SDR_c; cd05233 391619010380 NAD(P) binding site [chemical binding]; other site 391619010381 active site 391619010382 Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312 391619010383 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 391619010384 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 391619010385 active site 391619010386 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 391619010387 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 391619010388 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 391619010389 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 391619010390 Thioredoxin; Region: Thioredoxin_4; pfam13462 391619010391 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 391619010392 Protein of unknown function (DUF721); Region: DUF721; pfam05258 391619010393 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 391619010394 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 391619010395 minor groove reading motif; other site 391619010396 helix-hairpin-helix signature motif; other site 391619010397 substrate binding pocket [chemical binding]; other site 391619010398 active site 391619010399 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 391619010400 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 391619010401 DNA binding and oxoG recognition site [nucleotide binding] 391619010402 Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512 391619010403 Fatty acid desaturase; Region: FA_desaturase; pfam00487 391619010404 Di-iron ligands [ion binding]; other site 391619010405 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 391619010406 cyclase homology domain; Region: CHD; cd07302 391619010407 nucleotidyl binding site; other site 391619010408 metal binding site [ion binding]; metal-binding site 391619010409 dimer interface [polypeptide binding]; other site 391619010410 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 391619010411 DNA methylase; Region: N6_N4_Mtase; pfam01555 391619010412 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 391619010413 RNA/DNA hybrid binding site [nucleotide binding]; other site 391619010414 active site 391619010415 Domain of unknown function (DUF427); Region: DUF427; pfam04248 391619010416 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 391619010417 cyclase homology domain; Region: CHD; cd07302 391619010418 nucleotidyl binding site; other site 391619010419 metal binding site [ion binding]; metal-binding site 391619010420 dimer interface [polypeptide binding]; other site 391619010421 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 391619010422 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181 391619010423 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 391619010424 tetramer interface [polypeptide binding]; other site 391619010425 TPP-binding site [chemical binding]; other site 391619010426 heterodimer interface [polypeptide binding]; other site 391619010427 phosphorylation loop region [posttranslational modification] 391619010428 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 391619010429 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 391619010430 alpha subunit interface [polypeptide binding]; other site 391619010431 TPP binding site [chemical binding]; other site 391619010432 heterodimer interface [polypeptide binding]; other site 391619010433 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 391619010434 BCCT family transporter; Region: BCCT; pfam02028 391619010435 BCCT family transporter; Region: BCCT; pfam02028 391619010436 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391619010437 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 391619010438 DNA binding residues [nucleotide binding] 391619010439 Integrase core domain; Region: rve; pfam00665 391619010440 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 391619010441 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391619010442 Walker A motif; other site 391619010443 ATP binding site [chemical binding]; other site 391619010444 Walker B motif; other site 391619010445 arginine finger; other site 391619010446 TniQ; Region: TniQ; pfam06527 391619010447 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391619010448 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391619010449 LysR substrate binding domain; Region: LysR_substrate; pfam03466 391619010450 dimerization interface [polypeptide binding]; other site 391619010451 D-cysteine desulfhydrase; Validated; Region: PRK03910 391619010452 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 391619010453 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391619010454 catalytic residue [active] 391619010455 Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518 391619010456 aspartate racemase; Region: asp_race; TIGR00035 391619010457 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391619010458 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391619010459 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 391619010460 dimerization interface [polypeptide binding]; other site 391619010461 ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891 391619010462 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 391619010463 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 391619010464 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 391619010465 Walker A/P-loop; other site 391619010466 ATP binding site [chemical binding]; other site 391619010467 Q-loop/lid; other site 391619010468 ABC transporter signature motif; other site 391619010469 Walker B; other site 391619010470 D-loop; other site 391619010471 H-loop/switch region; other site 391619010472 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619010473 dimer interface [polypeptide binding]; other site 391619010474 conserved gate region; other site 391619010475 putative PBP binding loops; other site 391619010476 ABC-ATPase subunit interface; other site 391619010477 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 391619010478 Putative serine esterase (DUF676); Region: DUF676; pfam05057 391619010479 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391619010480 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391619010481 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391619010482 dimerization interface [polypeptide binding]; other site 391619010483 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 391619010484 intersubunit interface [polypeptide binding]; other site 391619010485 active site 391619010486 Zn2+ binding site [ion binding]; other site 391619010487 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 391619010488 Sulfatase; Region: Sulfatase; cl17466 391619010489 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391619010490 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503 391619010491 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 391619010492 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 391619010493 active site 391619010494 metal binding site [ion binding]; metal-binding site 391619010495 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391619010496 Walker A motif; other site 391619010497 ATP binding site [chemical binding]; other site 391619010498 Walker B motif; other site 391619010499 Transcriptional regulators [Transcription]; Region: PurR; COG1609 391619010500 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 391619010501 DNA binding site [nucleotide binding] 391619010502 domain linker motif; other site 391619010503 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 391619010504 putative dimerization interface [polypeptide binding]; other site 391619010505 putative ligand binding site [chemical binding]; other site 391619010506 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 391619010507 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 391619010508 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 391619010509 active site 391619010510 DctM-like transporters; Region: DctM; pfam06808 391619010511 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 391619010512 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274 391619010513 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 391619010514 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 391619010515 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 391619010516 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 391619010517 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 391619010518 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 391619010519 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 391619010520 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 391619010521 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 391619010522 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 391619010523 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391619010524 FeS/SAM binding site; other site 391619010525 Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cl17391 391619010526 AAA domain; Region: AAA_33; pfam13671 391619010527 P-loop motif; other site 391619010528 ATP binding site [chemical binding]; other site 391619010529 Chloramphenicol (Cm) binding site [chemical binding]; other site 391619010530 catalytic residue [active] 391619010531 Cytochrome C1 family; Region: Cytochrom_C1; pfam02167 391619010532 cytochrome b; Provisional; Region: CYTB; MTH00191 391619010533 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284 391619010534 intrachain domain interface; other site 391619010535 interchain domain interface [polypeptide binding]; other site 391619010536 heme bH binding site [chemical binding]; other site 391619010537 Qi binding site; other site 391619010538 heme bL binding site [chemical binding]; other site 391619010539 Qo binding site; other site 391619010540 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290 391619010541 interchain domain interface [polypeptide binding]; other site 391619010542 intrachain domain interface; other site 391619010543 Qi binding site; other site 391619010544 Qo binding site; other site 391619010545 Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399 391619010546 ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416 391619010547 Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470 391619010548 [2Fe-2S] cluster binding site [ion binding]; other site 391619010549 putative glutathione S-transferase; Provisional; Region: PRK10357 391619010550 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 391619010551 putative C-terminal domain interface [polypeptide binding]; other site 391619010552 putative GSH binding site (G-site) [chemical binding]; other site 391619010553 putative dimer interface [polypeptide binding]; other site 391619010554 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 391619010555 dimer interface [polypeptide binding]; other site 391619010556 N-terminal domain interface [polypeptide binding]; other site 391619010557 putative substrate binding pocket (H-site) [chemical binding]; other site 391619010558 riboflavin synthase subunit beta; Provisional; Region: PRK12419 391619010559 active site 391619010560 homopentamer interface [polypeptide binding]; other site 391619010561 ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840 391619010562 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391619010563 Walker A/P-loop; other site 391619010564 ATP binding site [chemical binding]; other site 391619010565 Q-loop/lid; other site 391619010566 ABC transporter signature motif; other site 391619010567 Walker B; other site 391619010568 D-loop; other site 391619010569 H-loop/switch region; other site 391619010570 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 391619010571 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 391619010572 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 391619010573 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 391619010574 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 391619010575 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 391619010576 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 391619010577 Tetramer interface [polypeptide binding]; other site 391619010578 active site 391619010579 FMN-binding site [chemical binding]; other site 391619010580 malonyl-CoA synthase; Validated; Region: PRK07514 391619010581 Malonyl-CoA synthetase (MCS); Region: MCS; cd05941 391619010582 acyl-activating enzyme (AAE) consensus motif; other site 391619010583 active site 391619010584 AMP binding site [chemical binding]; other site 391619010585 CoA binding site [chemical binding]; other site 391619010586 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 391619010587 EamA-like transporter family; Region: EamA; pfam00892 391619010588 EamA-like transporter family; Region: EamA; cl17759 391619010589 Transcriptional regulators [Transcription]; Region: MarR; COG1846 391619010590 MarR family; Region: MarR; pfam01047 391619010591 peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561 391619010592 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 391619010593 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 391619010594 homodimer interface [polypeptide binding]; other site 391619010595 substrate-cofactor binding pocket; other site 391619010596 catalytic residue [active] 391619010597 Transcriptional regulators [Transcription]; Region: MarR; COG1846 391619010598 MarR family; Region: MarR_2; pfam12802 391619010599 osmolarity response regulator; Provisional; Region: ompR; PRK09468 391619010600 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391619010601 active site 391619010602 phosphorylation site [posttranslational modification] 391619010603 intermolecular recognition site; other site 391619010604 dimerization interface [polypeptide binding]; other site 391619010605 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 391619010606 DNA binding site [nucleotide binding] 391619010607 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 391619010608 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599 391619010609 putative active site [active] 391619010610 Zn binding site [ion binding]; other site 391619010611 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 391619010612 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 391619010613 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 391619010614 substrate binding pocket [chemical binding]; other site 391619010615 chain length determination region; other site 391619010616 substrate-Mg2+ binding site; other site 391619010617 catalytic residues [active] 391619010618 aspartate-rich region 1; other site 391619010619 active site lid residues [active] 391619010620 aspartate-rich region 2; other site 391619010621 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 391619010622 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 391619010623 TPP-binding site; other site 391619010624 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 391619010625 PYR/PP interface [polypeptide binding]; other site 391619010626 dimer interface [polypeptide binding]; other site 391619010627 TPP binding site [chemical binding]; other site 391619010628 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 391619010629 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 391619010630 putative NAD(P) binding site [chemical binding]; other site 391619010631 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 391619010632 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391619010633 S-adenosylmethionine binding site [chemical binding]; other site 391619010634 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 391619010635 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391619010636 substrate binding site [chemical binding]; other site 391619010637 oxyanion hole (OAH) forming residues; other site 391619010638 trimer interface [polypeptide binding]; other site 391619010639 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 391619010640 CoA binding domain; Region: CoA_binding_2; pfam13380 391619010641 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 391619010642 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 391619010643 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391619010644 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391619010645 active site 391619010646 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 391619010647 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 391619010648 conserved cys residue [active] 391619010649 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391619010650 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 391619010651 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391619010652 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 391619010653 active site 391619010654 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 391619010655 AMP nucleosidase; Provisional; Region: PRK08292 391619010656 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 391619010657 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 391619010658 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 391619010659 IHF dimer interface [polypeptide binding]; other site 391619010660 IHF - DNA interface [nucleotide binding]; other site 391619010661 EamA-like transporter family; Region: EamA; pfam00892 391619010662 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 391619010663 EamA-like transporter family; Region: EamA; pfam00892 391619010664 methionine sulfoxide reductase B; Provisional; Region: PRK00222 391619010665 SelR domain; Region: SelR; pfam01641 391619010666 methionine sulfoxide reductase A; Provisional; Region: PRK14054 391619010667 N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145 391619010668 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 391619010669 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 391619010670 epoxyqueuosine reductase; Region: TIGR00276 391619010671 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 391619010672 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 391619010673 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 391619010674 NAD(P) binding site [chemical binding]; other site 391619010675 2-amino-3-ketobutyrate coenzyme A ligase; Provisional; Region: PRK06939 391619010676 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 391619010677 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391619010678 catalytic residue [active] 391619010679 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391619010680 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391619010681 non-specific DNA binding site [nucleotide binding]; other site 391619010682 salt bridge; other site 391619010683 sequence-specific DNA binding site [nucleotide binding]; other site 391619010684 Cupin domain; Region: Cupin_2; cl17218 391619010685 beta-ketothiolase; Provisional; Region: PRK09051 391619010686 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 391619010687 dimer interface [polypeptide binding]; other site 391619010688 active site 391619010689 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391619010690 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619010691 dimer interface [polypeptide binding]; other site 391619010692 conserved gate region; other site 391619010693 putative PBP binding loops; other site 391619010694 ABC-ATPase subunit interface; other site 391619010695 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 391619010696 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619010697 dimer interface [polypeptide binding]; other site 391619010698 conserved gate region; other site 391619010699 putative PBP binding loops; other site 391619010700 ABC-ATPase subunit interface; other site 391619010701 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 391619010702 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391619010703 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391619010704 Walker A/P-loop; other site 391619010705 ATP binding site [chemical binding]; other site 391619010706 Q-loop/lid; other site 391619010707 ABC transporter signature motif; other site 391619010708 Walker B; other site 391619010709 D-loop; other site 391619010710 H-loop/switch region; other site 391619010711 TOBE domain; Region: TOBE_2; pfam08402 391619010712 putative aminotransferase; Validated; Region: PRK07480 391619010713 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 391619010714 inhibitor-cofactor binding pocket; inhibition site 391619010715 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391619010716 catalytic residue [active] 391619010717 Transcriptional regulators [Transcription]; Region: GntR; COG1802 391619010718 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391619010719 DNA-binding site [nucleotide binding]; DNA binding site 391619010720 FCD domain; Region: FCD; pfam07729 391619010721 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 391619010722 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 391619010723 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 391619010724 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391619010725 Walker A/P-loop; other site 391619010726 ATP binding site [chemical binding]; other site 391619010727 Q-loop/lid; other site 391619010728 ABC transporter signature motif; other site 391619010729 Walker B; other site 391619010730 D-loop; other site 391619010731 H-loop/switch region; other site 391619010732 TOBE domain; Region: TOBE_2; pfam08402 391619010733 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619010734 dimer interface [polypeptide binding]; other site 391619010735 conserved gate region; other site 391619010736 putative PBP binding loops; other site 391619010737 ABC-ATPase subunit interface; other site 391619010738 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 391619010739 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619010740 dimer interface [polypeptide binding]; other site 391619010741 conserved gate region; other site 391619010742 putative PBP binding loops; other site 391619010743 ABC-ATPase subunit interface; other site 391619010744 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 391619010745 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 391619010746 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 391619010747 NAD binding site [chemical binding]; other site 391619010748 homodimer interface [polypeptide binding]; other site 391619010749 active site 391619010750 substrate binding site [chemical binding]; other site 391619010751 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 391619010752 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 391619010753 active site 391619010754 tetramer interface; other site 391619010755 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 391619010756 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 391619010757 Ligand binding site; other site 391619010758 oligomer interface; other site 391619010759 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 391619010760 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 391619010761 active site 391619010762 ABC-2 type transporter; Region: ABC2_membrane; cl17235 391619010763 2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532 391619010764 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 391619010765 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 391619010766 nucleotide binding site [chemical binding]; other site 391619010767 NEF interaction site [polypeptide binding]; other site 391619010768 SBD interface [polypeptide binding]; other site 391619010769 chaperone protein DnaJ; Provisional; Region: PRK10767 391619010770 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 391619010771 HSP70 interaction site [polypeptide binding]; other site 391619010772 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 391619010773 substrate binding site [polypeptide binding]; other site 391619010774 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 391619010775 Zn binding sites [ion binding]; other site 391619010776 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 391619010777 dimer interface [polypeptide binding]; other site 391619010778 hypothetical protein; Reviewed; Region: PRK00024 391619010779 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 391619010780 MPN+ (JAMM) motif; other site 391619010781 Zinc-binding site [ion binding]; other site 391619010782 PBP superfamily domain; Region: PBP_like_2; cl17296 391619010783 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 391619010784 ligand binding site [chemical binding]; other site 391619010785 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 391619010786 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 391619010787 SEC-C motif; Region: SEC-C; pfam02810 391619010788 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 391619010789 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 391619010790 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 391619010791 heterotetramer interface [polypeptide binding]; other site 391619010792 active site pocket [active] 391619010793 cleavage site 391619010794 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 391619010795 active site 391619010796 8-oxo-dGMP binding site [chemical binding]; other site 391619010797 nudix motif; other site 391619010798 metal binding site [ion binding]; metal-binding site 391619010799 translation initiation factor IF-2; Region: IF-2; TIGR00487 391619010800 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 391619010801 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 391619010802 G1 box; other site 391619010803 putative GEF interaction site [polypeptide binding]; other site 391619010804 GTP/Mg2+ binding site [chemical binding]; other site 391619010805 Switch I region; other site 391619010806 G2 box; other site 391619010807 G3 box; other site 391619010808 Switch II region; other site 391619010809 G4 box; other site 391619010810 G5 box; other site 391619010811 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 391619010812 Translation-initiation factor 2; Region: IF-2; pfam11987 391619010813 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 391619010814 hypothetical protein; Provisional; Region: PRK09190 391619010815 Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279 391619010816 putative RNA binding cleft [nucleotide binding]; other site 391619010817 Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600 391619010818 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 391619010819 NusA N-terminal domain; Region: NusA_N; pfam08529 391619010820 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 391619010821 RNA binding site [nucleotide binding]; other site 391619010822 homodimer interface [polypeptide binding]; other site 391619010823 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 391619010824 G-X-X-G motif; other site 391619010825 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 391619010826 G-X-X-G motif; other site 391619010827 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 391619010828 ribosome maturation protein RimP; Reviewed; Region: PRK00092 391619010829 Sm and related proteins; Region: Sm_like; cl00259 391619010830 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 391619010831 putative oligomer interface [polypeptide binding]; other site 391619010832 putative RNA binding site [nucleotide binding]; other site 391619010833 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 391619010834 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391619010835 proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249 391619010836 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 391619010837 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391619010838 S-adenosylmethionine binding site [chemical binding]; other site 391619010839 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 391619010840 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 391619010841 MarR family; Region: MarR_2; pfam12802 391619010842 nitrilase; Region: PLN02798 391619010843 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 391619010844 putative active site [active] 391619010845 catalytic triad [active] 391619010846 dimer interface [polypeptide binding]; other site 391619010847 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 391619010848 GSH binding site [chemical binding]; other site 391619010849 catalytic residues [active] 391619010850 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 391619010851 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 391619010852 active site 391619010853 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 391619010854 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 391619010855 ferrochelatase; Reviewed; Region: hemH; PRK00035 391619010856 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 391619010857 C-terminal domain interface [polypeptide binding]; other site 391619010858 active site 391619010859 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 391619010860 active site 391619010861 N-terminal domain interface [polypeptide binding]; other site 391619010862 hypothetical protein; Provisional; Region: PRK06148 391619010863 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 391619010864 active site 391619010865 ATP binding site [chemical binding]; other site 391619010866 Peptidase family M23; Region: Peptidase_M23; pfam01551 391619010867 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 391619010868 inhibitor-cofactor binding pocket; inhibition site 391619010869 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391619010870 catalytic residue [active] 391619010871 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 391619010872 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 391619010873 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 391619010874 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 391619010875 Ion transport protein; Region: Ion_trans; pfam00520 391619010876 SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265 391619010877 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391619010878 S-adenosylmethionine binding site [chemical binding]; other site 391619010879 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 391619010880 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 391619010881 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391619010882 Walker A/P-loop; other site 391619010883 ATP binding site [chemical binding]; other site 391619010884 Q-loop/lid; other site 391619010885 ABC transporter signature motif; other site 391619010886 Walker B; other site 391619010887 D-loop; other site 391619010888 H-loop/switch region; other site 391619010889 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 391619010890 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391619010891 Walker A/P-loop; other site 391619010892 ATP binding site [chemical binding]; other site 391619010893 Q-loop/lid; other site 391619010894 ABC transporter signature motif; other site 391619010895 Walker B; other site 391619010896 D-loop; other site 391619010897 H-loop/switch region; other site 391619010898 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 391619010899 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 391619010900 active site 391619010901 NTP binding site [chemical binding]; other site 391619010902 metal binding triad [ion binding]; metal-binding site 391619010903 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 391619010904 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 391619010905 putative active site [active] 391619010906 putative CoA binding site [chemical binding]; other site 391619010907 nudix motif; other site 391619010908 metal binding site [ion binding]; metal-binding site 391619010909 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 391619010910 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 391619010911 dimerization interface [polypeptide binding]; other site 391619010912 domain crossover interface; other site 391619010913 redox-dependent activation switch; other site 391619010914 Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684 391619010915 nudix motif; other site 391619010916 Response regulator receiver domain; Region: Response_reg; pfam00072 391619010917 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391619010918 active site 391619010919 phosphorylation site [posttranslational modification] 391619010920 intermolecular recognition site; other site 391619010921 dimerization interface [polypeptide binding]; other site 391619010922 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 391619010923 Hpt domain; Region: Hpt; pfam01627 391619010924 putative binding surface; other site 391619010925 active site 391619010926 threonine dehydratase; Validated; Region: PRK08639 391619010927 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 391619010928 tetramer interface [polypeptide binding]; other site 391619010929 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391619010930 catalytic residue [active] 391619010931 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 391619010932 argininosuccinate synthase; Provisional; Region: PRK13820 391619010933 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 391619010934 ANP binding site [chemical binding]; other site 391619010935 Substrate Binding Site II [chemical binding]; other site 391619010936 Substrate Binding Site I [chemical binding]; other site 391619010937 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 391619010938 SCP-2 sterol transfer family; Region: SCP2; pfam02036 391619010939 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 391619010940 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 391619010941 homodimer interface [polypeptide binding]; other site 391619010942 substrate-cofactor binding pocket; other site 391619010943 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391619010944 catalytic residue [active] 391619010945 Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625 391619010946 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 391619010947 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 391619010948 substrate binding site [chemical binding]; other site 391619010949 dimer interface [polypeptide binding]; other site 391619010950 ATP binding site [chemical binding]; other site 391619010951 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 391619010952 Malic enzyme, N-terminal domain; Region: malic; pfam00390 391619010953 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 391619010954 putative NAD(P) binding site [chemical binding]; other site 391619010955 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 391619010956 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 391619010957 MutS domain I; Region: MutS_I; pfam01624 391619010958 MutS domain II; Region: MutS_II; pfam05188 391619010959 MutS domain III; Region: MutS_III; pfam05192 391619010960 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 391619010961 Walker A/P-loop; other site 391619010962 ATP binding site [chemical binding]; other site 391619010963 Q-loop/lid; other site 391619010964 ABC transporter signature motif; other site 391619010965 Walker B; other site 391619010966 D-loop; other site 391619010967 H-loop/switch region; other site 391619010968 GrpE; Region: GrpE; pfam01025 391619010969 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 391619010970 dimer interface [polypeptide binding]; other site 391619010971 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 391619010972 heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082 391619010973 Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444 391619010974 ribonuclease PH; Reviewed; Region: rph; PRK00173 391619010975 Ribonuclease PH; Region: RNase_PH_bact; cd11362 391619010976 hexamer interface [polypeptide binding]; other site 391619010977 active site 391619010978 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 391619010979 active site 391619010980 dimerization interface [polypeptide binding]; other site 391619010981 coproporphyrinogen III oxidase; Provisional; Region: PRK09057 391619010982 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391619010983 FeS/SAM binding site; other site 391619010984 HemN C-terminal domain; Region: HemN_C; pfam06969 391619010985 Protein of unknown function (DUF454); Region: DUF454; pfam04304 391619010986 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 391619010987 ParB-like nuclease domain; Region: ParBc; pfam02195 391619010988 KorB domain; Region: KorB; pfam08535 391619010989 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 391619010990 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 391619010991 P-loop; other site 391619010992 Magnesium ion binding site [ion binding]; other site 391619010993 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 391619010994 Magnesium ion binding site [ion binding]; other site 391619010995 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 391619010996 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391619010997 S-adenosylmethionine binding site [chemical binding]; other site 391619010998 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 391619010999 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 391619011000 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 391619011001 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 391619011002 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 391619011003 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391619011004 trmE is a tRNA modification GTPase; Region: trmE; cd04164 391619011005 G1 box; other site 391619011006 Walker A/P-loop; other site 391619011007 GTP/Mg2+ binding site [chemical binding]; other site 391619011008 ATP binding site [chemical binding]; other site 391619011009 Switch I region; other site 391619011010 G2 box; other site 391619011011 Switch II region; other site 391619011012 G3 box; other site 391619011013 G4 box; other site 391619011014 G5 box; other site 391619011015 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 391619011016 transcription termination factor Rho; Provisional; Region: rho; PRK09376 391619011017 Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498 391619011018 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 391619011019 RNA binding site [nucleotide binding]; other site 391619011020 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 391619011021 multimer interface [polypeptide binding]; other site 391619011022 Walker A motif; other site 391619011023 ATP binding site [chemical binding]; other site 391619011024 Walker B motif; other site 391619011025 Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653 391619011026 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 391619011027 active site 391619011028 dimer interface [polypeptide binding]; other site 391619011029 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 391619011030 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 391619011031 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 391619011032 shikimate binding site; other site 391619011033 NAD(P) binding site [chemical binding]; other site 391619011034 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 391619011035 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 391619011036 CoA-binding site [chemical binding]; other site 391619011037 ATP-binding [chemical binding]; other site 391619011038 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 391619011039 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 391619011040 active site 391619011041 catalytic site [active] 391619011042 substrate binding site [chemical binding]; other site 391619011043 Preprotein translocase subunit SecB; Region: SecB; pfam02556 391619011044 SecA binding site; other site 391619011045 Preprotein binding site; other site 391619011046 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 391619011047 Tim44-like domain; Region: Tim44; pfam04280 391619011048 MltA specific insert domain; Region: MltA; smart00925 391619011049 3D domain; Region: 3D; pfam06725 391619011050 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 391619011051 Smr domain; Region: Smr; pfam01713 391619011052 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 391619011053 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 391619011054 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391619011055 Walker A motif; other site 391619011056 ATP binding site [chemical binding]; other site 391619011057 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 391619011058 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 391619011059 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 391619011060 active site 391619011061 HslU subunit interaction site [polypeptide binding]; other site 391619011062 Domain of unknown function (DUF1127); Region: DUF1127; pfam06568 391619011063 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; pfam09585 391619011064 Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; pfam09585 391619011065 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 391619011066 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 391619011067 catalytic residues [active] 391619011068 double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784 391619011069 Part of AAA domain; Region: AAA_19; pfam13245 391619011070 Family description; Region: UvrD_C_2; pfam13538 391619011071 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 391619011072 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 391619011073 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 391619011074 NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422 391619011075 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 391619011076 Substrate binding site; other site 391619011077 metal-binding site 391619011078 Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178 391619011079 Phosphotransferase enzyme family; Region: APH; pfam01636 391619011080 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 391619011081 PAS fold; Region: PAS_7; pfam12860 391619011082 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 391619011083 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391619011084 dimer interface [polypeptide binding]; other site 391619011085 phosphorylation site [posttranslational modification] 391619011086 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391619011087 ATP binding site [chemical binding]; other site 391619011088 Mg2+ binding site [ion binding]; other site 391619011089 G-X-G motif; other site 391619011090 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 391619011091 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 391619011092 Cu(I) binding site [ion binding]; other site 391619011093 Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567 391619011094 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391619011095 active site 391619011096 phosphorylation site [posttranslational modification] 391619011097 intermolecular recognition site; other site 391619011098 dimerization interface [polypeptide binding]; other site 391619011099 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 391619011100 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 391619011101 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 391619011102 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 391619011103 homotetramer interface [polypeptide binding]; other site 391619011104 ligand binding site [chemical binding]; other site 391619011105 catalytic site [active] 391619011106 NAD binding site [chemical binding]; other site 391619011107 PRC-barrel domain; Region: PRC; pfam05239 391619011108 Protein of unknown function (DUF2853); Region: DUF2853; pfam11015 391619011109 Protein of unknown function (DUF1761); Region: DUF1761; pfam08570 391619011110 EVE domain; Region: EVE; cl00728 391619011111 YciI-like protein; Reviewed; Region: PRK12863 391619011112 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 391619011113 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 391619011114 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 391619011115 UGMP family protein; Validated; Region: PRK09604 391619011116 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 391619011117 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 391619011118 active site 391619011119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223 391619011120 HemY protein N-terminus; Region: HemY_N; pfam07219 391619011121 Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898 391619011122 choline dehydrogenase; Validated; Region: PRK02106 391619011123 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391619011124 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 391619011125 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008 391619011126 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119 391619011127 dimer interface [polypeptide binding]; other site 391619011128 acyl-activating enzyme (AAE) consensus motif; other site 391619011129 putative active site [active] 391619011130 AMP binding site [chemical binding]; other site 391619011131 putative CoA binding site [chemical binding]; other site 391619011132 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 391619011133 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 391619011134 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 391619011135 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 391619011136 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 391619011137 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 391619011138 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 391619011139 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521 391619011140 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 391619011141 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008 391619011142 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 391619011143 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 391619011144 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 391619011145 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 391619011146 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 391619011147 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 391619011148 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 391619011149 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 391619011150 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 391619011151 Uncharacterized conserved protein [Function unknown]; Region: COG3334 391619011152 flagellar motor protein MotA; Validated; Region: PRK09110 391619011153 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 391619011154 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 391619011155 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391619011156 catalytic residue [active] 391619011157 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 391619011158 FHIPEP family; Region: FHIPEP; pfam00771 391619011159 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 391619011160 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 391619011161 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 391619011162 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 391619011163 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 391619011164 SAF-like; Region: SAF_2; pfam13144 391619011165 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 391619011166 flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691 391619011167 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 391619011168 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 391619011169 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12690 391619011170 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 391619011171 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 391619011172 Bacterial export proteins, family 3; Region: Bac_export_3; pfam01313 391619011173 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790 391619011174 flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12632 391619011175 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 391619011176 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12627 391619011177 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 391619011178 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 391619011179 Walker A motif; other site 391619011180 ATP binding site [chemical binding]; other site 391619011181 Walker B motif; other site 391619011182 flagellar biosynthesis repressor FlbT; Reviewed; Region: flbT; PRK00794 391619011183 flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12794 391619011184 flagellin; Reviewed; Region: PRK12687 391619011185 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 391619011186 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 391619011187 Rod binding protein; Region: Rod-binding; pfam10135 391619011188 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 391619011189 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 391619011190 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 391619011191 Phosphotransferase enzyme family; Region: APH; pfam01636 391619011192 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 391619011193 active site 391619011194 substrate binding site [chemical binding]; other site 391619011195 ATP binding site [chemical binding]; other site 391619011196 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 391619011197 active site 391619011198 Core-2/I-Branching enzyme; Region: Branch; pfam02485 391619011199 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 391619011200 active site 391619011201 phosphorylation site [posttranslational modification] 391619011202 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 391619011203 30S subunit binding site; other site 391619011204 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 391619011205 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 391619011206 Walker A/P-loop; other site 391619011207 ATP binding site [chemical binding]; other site 391619011208 Q-loop/lid; other site 391619011209 ABC transporter signature motif; other site 391619011210 Walker B; other site 391619011211 D-loop; other site 391619011212 H-loop/switch region; other site 391619011213 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 391619011214 OstA-like protein; Region: OstA; pfam03968 391619011215 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 391619011216 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 391619011217 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 391619011218 putative active site [active] 391619011219 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 391619011220 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 391619011221 catalytic site [active] 391619011222 putative active site [active] 391619011223 putative substrate binding site [chemical binding]; other site 391619011224 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 391619011225 heme-binding site [chemical binding]; other site 391619011226 NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271 391619011227 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 391619011228 putative NAD(P) binding site [chemical binding]; other site 391619011229 active site 391619011230 Bacitracin resistance protein BacA; Region: BacA; pfam02673 391619011231 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 391619011232 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 391619011233 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 391619011234 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 391619011235 active site 391619011236 dimer interface [polypeptide binding]; other site 391619011237 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 391619011238 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 391619011239 active site 391619011240 FMN binding site [chemical binding]; other site 391619011241 substrate binding site [chemical binding]; other site 391619011242 3Fe-4S cluster binding site [ion binding]; other site 391619011243 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 391619011244 domain interface; other site 391619011245 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 391619011246 Transglycosylase; Region: Transgly; cl17702 391619011247 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 391619011248 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 391619011249 C-terminal domain interface [polypeptide binding]; other site 391619011250 GSH binding site (G-site) [chemical binding]; other site 391619011251 dimer interface [polypeptide binding]; other site 391619011252 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299 391619011253 N-terminal domain interface [polypeptide binding]; other site 391619011254 dimer interface [polypeptide binding]; other site 391619011255 substrate binding pocket (H-site) [chemical binding]; other site 391619011256 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 391619011257 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 391619011258 active site 391619011259 metal binding site [ion binding]; metal-binding site 391619011260 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 391619011261 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 391619011262 ligand binding site [chemical binding]; other site 391619011263 NAD binding site [chemical binding]; other site 391619011264 dimerization interface [polypeptide binding]; other site 391619011265 catalytic site [active] 391619011266 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 391619011267 putative L-serine binding site [chemical binding]; other site 391619011268 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494 391619011269 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391619011270 catalytic residue [active] 391619011271 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 391619011272 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 391619011273 motif II; other site 391619011274 hypothetical protein; Provisional; Region: PRK10621 391619011275 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 391619011276 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391619011277 dimerization interface [polypeptide binding]; other site 391619011278 putative DNA binding site [nucleotide binding]; other site 391619011279 putative Zn2+ binding site [ion binding]; other site 391619011280 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 391619011281 putative hydrophobic ligand binding site [chemical binding]; other site 391619011282 YCII-related domain; Region: YCII; cl00999 391619011283 L-asparaginase II; Region: Asparaginase_II; pfam06089 391619011284 Protein of unknown function (DUF1311); Region: DUF1311; cl01530 391619011285 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 391619011286 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 391619011287 FeS/SAM binding site; other site 391619011288 Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277 391619011289 active site 391619011290 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 391619011291 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 391619011292 hypothetical protein; Provisional; Region: PRK06815 391619011293 threonine dehydratase; Provisional; Region: PRK08246 391619011294 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391619011295 catalytic residue [active] 391619011296 Transcriptional regulators [Transcription]; Region: FadR; COG2186 391619011297 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391619011298 DNA-binding site [nucleotide binding]; DNA binding site 391619011299 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 391619011300 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 391619011301 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 391619011302 trimer interface [polypeptide binding]; other site 391619011303 active site 391619011304 substrate binding site [chemical binding]; other site 391619011305 CoA binding site [chemical binding]; other site 391619011306 urocanate hydratase; Provisional; Region: PRK05414 391619011307 RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169 391619011308 N-formylglutamate amidohydrolase; Region: FGase; cl01522 391619011309 Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332 391619011310 active sites [active] 391619011311 tetramer interface [polypeptide binding]; other site 391619011312 imidazolonepropionase; Validated; Region: PRK09356 391619011313 Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296 391619011314 active site 391619011315 N-formimino-L-glutamate deiminase; Validated; Region: PRK09229 391619011316 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391619011317 active site 391619011318 histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018 391619011319 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391619011320 DNA-binding site [nucleotide binding]; DNA binding site 391619011321 UTRA domain; Region: UTRA; pfam07702 391619011322 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391619011323 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391619011324 substrate binding pocket [chemical binding]; other site 391619011325 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391619011326 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391619011327 membrane-bound complex binding site; other site 391619011328 hinge residues; other site 391619011329 Hint domain; Region: Hint_2; pfam13403 391619011330 Hint domain; Region: Hint_2; pfam13403 391619011331 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 391619011332 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 391619011333 metal binding site [ion binding]; metal-binding site 391619011334 dimer interface [polypeptide binding]; other site 391619011335 ribonuclease R; Region: RNase_R; TIGR02063 391619011336 RNB domain; Region: RNB; pfam00773 391619011337 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 391619011338 RNA binding site [nucleotide binding]; other site 391619011339 Predicted transcriptional regulator [Transcription]; Region: COG2378 391619011340 HTH domain; Region: HTH_11; pfam08279 391619011341 WYL domain; Region: WYL; pfam13280 391619011342 Transglycosylase SLT domain; Region: SLT_2; pfam13406 391619011343 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 391619011344 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391619011345 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 391619011346 ABC1 family; Region: ABC1; cl17513 391619011347 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 391619011348 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 391619011349 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391619011350 S-adenosylmethionine binding site [chemical binding]; other site 391619011351 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 391619011352 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 391619011353 DNA binding site [nucleotide binding] 391619011354 catalytic residue [active] 391619011355 H2TH interface [polypeptide binding]; other site 391619011356 putative catalytic residues [active] 391619011357 turnover-facilitating residue; other site 391619011358 intercalation triad [nucleotide binding]; other site 391619011359 8OG recognition residue [nucleotide binding]; other site 391619011360 putative reading head residues; other site 391619011361 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 391619011362 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 391619011363 enoyl-CoA hydratase; Provisional; Region: PRK05862 391619011364 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391619011365 substrate binding site [chemical binding]; other site 391619011366 oxyanion hole (OAH) forming residues; other site 391619011367 trimer interface [polypeptide binding]; other site 391619011368 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 391619011369 plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453 391619011370 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 391619011371 P-loop; other site 391619011372 Magnesium ion binding site [ion binding]; other site 391619011373 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 391619011374 Magnesium ion binding site [ion binding]; other site 391619011375 ParB-like nuclease domain; Region: ParB; smart00470 391619011376 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 391619011377 active site 391619011378 catalytic residues [active] 391619011379 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 391619011380 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 391619011381 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 391619011382 active site 391619011383 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 391619011384 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 391619011385 active site 391619011386 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 391619011387 O-Antigen ligase; Region: Wzy_C; pfam04932 391619011388 exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005 391619011389 Chain length determinant protein; Region: Wzz; pfam02706 391619011390 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 391619011391 ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525 391619011392 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 391619011393 Ligand binding site; other site 391619011394 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 391619011395 active site 391619011396 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 391619011397 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 391619011398 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 391619011399 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 391619011400 Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326 391619011401 putative ligand binding site [chemical binding]; other site 391619011402 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 391619011403 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 391619011404 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 391619011405 dimer interface [polypeptide binding]; other site 391619011406 putative CheW interface [polypeptide binding]; other site 391619011407 AzlC protein; Region: AzlC; cl00570 391619011408 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391619011409 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391619011410 putative DNA binding site [nucleotide binding]; other site 391619011411 putative Zn2+ binding site [ion binding]; other site 391619011412 AsnC family; Region: AsnC_trans_reg; pfam01037 391619011413 H+ Antiporter protein; Region: 2A0121; TIGR00900 391619011414 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 391619011415 putative substrate translocation pore; other site 391619011416 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 391619011417 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391619011418 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391619011419 dimerization interface [polypeptide binding]; other site 391619011420 choline dehydrogenase; Validated; Region: PRK02106 391619011421 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 391619011422 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 391619011423 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 391619011424 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 391619011425 active site pocket [active] 391619011426 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391619011427 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 391619011428 NAD(P) binding site [chemical binding]; other site 391619011429 catalytic residues [active] 391619011430 catalytic residues [active] 391619011431 Protein of unknown function (DUF1289); Region: DUF1289; cl01304 391619011432 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 391619011433 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 391619011434 dimerization interface [polypeptide binding]; other site 391619011435 DPS ferroxidase diiron center [ion binding]; other site 391619011436 ion pore; other site 391619011437 Transcriptional regulators [Transcription]; Region: GntR; COG1802 391619011438 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391619011439 DNA-binding site [nucleotide binding]; DNA binding site 391619011440 FCD domain; Region: FCD; pfam07729 391619011441 Proline racemase [Amino acid transport and metabolism]; Region: COG3938 391619011442 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 391619011443 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 391619011444 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391619011445 non-specific DNA binding site [nucleotide binding]; other site 391619011446 salt bridge; other site 391619011447 sequence-specific DNA binding site [nucleotide binding]; other site 391619011448 Cupin domain; Region: Cupin_2; pfam07883 391619011449 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391619011450 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995 391619011451 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391619011452 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619011453 dimer interface [polypeptide binding]; other site 391619011454 conserved gate region; other site 391619011455 putative PBP binding loops; other site 391619011456 ABC-ATPase subunit interface; other site 391619011457 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 391619011458 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 391619011459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619011460 dimer interface [polypeptide binding]; other site 391619011461 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 391619011462 ABC-ATPase subunit interface; other site 391619011463 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 391619011464 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391619011465 Walker A/P-loop; other site 391619011466 ATP binding site [chemical binding]; other site 391619011467 Q-loop/lid; other site 391619011468 ABC transporter signature motif; other site 391619011469 Walker B; other site 391619011470 D-loop; other site 391619011471 H-loop/switch region; other site 391619011472 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391619011473 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 391619011474 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391619011475 Walker A/P-loop; other site 391619011476 ATP binding site [chemical binding]; other site 391619011477 Q-loop/lid; other site 391619011478 ABC transporter signature motif; other site 391619011479 Walker B; other site 391619011480 D-loop; other site 391619011481 H-loop/switch region; other site 391619011482 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 391619011483 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 391619011484 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 391619011485 X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085 391619011486 active site 391619011487 Cache domain; Region: Cache_1; pfam02743 391619011488 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 391619011489 dimerization interface [polypeptide binding]; other site 391619011490 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 391619011491 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 391619011492 dimer interface [polypeptide binding]; other site 391619011493 putative CheW interface [polypeptide binding]; other site 391619011494 colanic acid exporter; Provisional; Region: PRK10459 391619011495 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 391619011496 Bacterial sugar transferase; Region: Bac_transf; pfam02397 391619011497 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 391619011498 active site 391619011499 catalytic residues [active] 391619011500 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 391619011501 Family description; Region: VCBS; pfam13517 391619011502 Family description; Region: VCBS; pfam13517 391619011503 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 391619011504 MarR family; Region: MarR_2; cl17246 391619011505 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 391619011506 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 391619011507 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 391619011508 D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634 391619011509 putative ligand binding site [chemical binding]; other site 391619011510 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391619011511 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391619011512 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 391619011513 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 391619011514 TM-ABC transporter signature motif; other site 391619011515 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 391619011516 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 391619011517 Walker A/P-loop; other site 391619011518 ATP binding site [chemical binding]; other site 391619011519 Q-loop/lid; other site 391619011520 ABC transporter signature motif; other site 391619011521 Walker B; other site 391619011522 D-loop; other site 391619011523 H-loop/switch region; other site 391619011524 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 391619011525 Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785 391619011526 DNA binding residues [nucleotide binding] 391619011527 dimer interface [polypeptide binding]; other site 391619011528 putative metal binding site [ion binding]; other site 391619011529 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 391619011530 Predicted transcriptional regulators containing the CopG/Arc/MetJ DNA-binding domain [Transcription]; Region: COG3609 391619011531 DNA ligase, ATP-dependent, PP_1105 family; Region: DNA_lig_bact; TIGR04120 391619011532 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 391619011533 active site 391619011534 DNA binding site [nucleotide binding] 391619011535 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 391619011536 DNA binding site [nucleotide binding] 391619011537 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 391619011538 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 391619011539 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 391619011540 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 391619011541 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 391619011542 active site 391619011543 DNA binding site [nucleotide binding] 391619011544 Int/Topo IB signature motif; other site 391619011545 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 391619011546 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 391619011547 NAD(P) binding site [chemical binding]; other site 391619011548 catalytic residues [active] 391619011549 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 391619011550 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 391619011551 FeS/SAM binding site; other site 391619011552 probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915 391619011553 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 391619011554 Fe-S cluster binding site [ion binding]; other site 391619011555 active site 391619011556 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 391619011557 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 391619011558 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 391619011559 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 391619011560 phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144 391619011561 active site 391619011562 metal binding site [ion binding]; metal-binding site 391619011563 Predicted membrane protein [Function unknown]; Region: COG2311 391619011564 Protein of unknown function (DUF418); Region: DUF418; pfam04235 391619011565 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 391619011566 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 391619011567 Transglycosylase SLT domain; Region: SLT_2; pfam13406 391619011568 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 391619011569 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391619011570 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 391619011571 Predicted periplasmic protein [Function unknown]; Region: COG3904 391619011572 Talin, middle domain; Region: Talin_middle; pfam09141 391619011573 MgtC family; Region: MgtC; pfam02308 391619011574 RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361 391619011575 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 391619011576 Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041 391619011577 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 391619011578 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391619011579 ATP binding site [chemical binding]; other site 391619011580 Mg2+ binding site [ion binding]; other site 391619011581 G-X-G motif; other site 391619011582 Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172 391619011583 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 391619011584 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cl00120 391619011585 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920 391619011586 Histidine kinase; Region: HisKA_2; pfam07568 391619011587 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391619011588 ATP binding site [chemical binding]; other site 391619011589 Mg2+ binding site [ion binding]; other site 391619011590 G-X-G motif; other site 391619011591 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 391619011592 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 391619011593 metal binding site [ion binding]; metal-binding site 391619011594 putative dimer interface [polypeptide binding]; other site 391619011595 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 391619011596 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 391619011597 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 391619011598 catalytic residue [active] 391619011599 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 391619011600 AsnC family; Region: AsnC_trans_reg; pfam01037 391619011601 Transglycosylase SLT domain; Region: SLT_2; pfam13406 391619011602 Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361 391619011603 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 391619011604 N-acetyl-D-glucosamine binding site [chemical binding]; other site 391619011605 catalytic residue [active] 391619011606 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 391619011607 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 391619011608 NAD(P) binding site [chemical binding]; other site 391619011609 active site 391619011610 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 391619011611 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 391619011612 NAD(P) binding site [chemical binding]; other site 391619011613 catalytic residues [active] 391619011614 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 391619011615 active site 2 [active] 391619011616 active site 1 [active] 391619011617 phosphopantothenoylcysteine decarboxylase, streptococcal; Region: coaC_strep; TIGR02113 391619011618 Flavoprotein; Region: Flavoprotein; pfam02441 391619011619 PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398 391619011620 active site 391619011621 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 391619011622 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 391619011623 transmembrane helices; other site 391619011624 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 391619011625 homodimer interaction site [polypeptide binding]; other site 391619011626 cofactor binding site; other site 391619011627 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_21; cd08520 391619011628 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 391619011629 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391619011630 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619011631 dimer interface [polypeptide binding]; other site 391619011632 conserved gate region; other site 391619011633 putative PBP binding loops; other site 391619011634 ABC-ATPase subunit interface; other site 391619011635 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 391619011636 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 391619011637 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391619011638 Walker A/P-loop; other site 391619011639 ATP binding site [chemical binding]; other site 391619011640 Q-loop/lid; other site 391619011641 ABC transporter signature motif; other site 391619011642 Walker B; other site 391619011643 D-loop; other site 391619011644 H-loop/switch region; other site 391619011645 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391619011646 Walker A/P-loop; other site 391619011647 ATP binding site [chemical binding]; other site 391619011648 Q-loop/lid; other site 391619011649 ABC transporter signature motif; other site 391619011650 Walker B; other site 391619011651 D-loop; other site 391619011652 H-loop/switch region; other site 391619011653 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 391619011654 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 391619011655 putative active site pocket [active] 391619011656 dimerization interface [polypeptide binding]; other site 391619011657 putative catalytic residue [active] 391619011658 Peptidase family M23; Region: Peptidase_M23; pfam01551 391619011659 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 391619011660 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 391619011661 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 391619011662 active site 391619011663 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 391619011664 active site 391619011665 Prephenate dehydratase; Region: PDT; pfam00800 391619011666 GST_N family, Beta etherase LigE subfamily; composed of proteins similar to Sphingomonas paucimobilis beta etherase, LigE, a GST-like protein that catalyzes the cleavage of the beta-aryl ether linkages present in low-moleculer weight lignins using GSH as...; Region: GST_N_etherase_LigE; cd03038 391619011667 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 391619011668 putative C-terminal domain interface [polypeptide binding]; other site 391619011669 putative GSH binding site (G-site) [chemical binding]; other site 391619011670 putative dimer interface [polypeptide binding]; other site 391619011671 C-terminal, alpha helical domain of Beta etherase LigE; Region: GST_C_etherase_LigE; cd03202 391619011672 putative N-terminal domain interface [polypeptide binding]; other site 391619011673 putative dimer interface [polypeptide binding]; other site 391619011674 putative substrate binding pocket (H-site) [chemical binding]; other site 391619011675 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391619011676 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391619011677 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 391619011678 dimerization interface [polypeptide binding]; other site 391619011679 cell density-dependent motility repressor; Provisional; Region: PRK10082 391619011680 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391619011681 LysR substrate binding domain; Region: LysR_substrate; pfam03466 391619011682 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 391619011683 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391619011684 Walker A/P-loop; other site 391619011685 ATP binding site [chemical binding]; other site 391619011686 Q-loop/lid; other site 391619011687 ABC transporter signature motif; other site 391619011688 Walker B; other site 391619011689 D-loop; other site 391619011690 H-loop/switch region; other site 391619011691 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 391619011692 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 391619011693 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391619011694 Walker A/P-loop; other site 391619011695 ATP binding site [chemical binding]; other site 391619011696 Q-loop/lid; other site 391619011697 ABC transporter signature motif; other site 391619011698 Walker B; other site 391619011699 D-loop; other site 391619011700 H-loop/switch region; other site 391619011701 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 391619011702 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 391619011703 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 391619011704 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619011705 dimer interface [polypeptide binding]; other site 391619011706 conserved gate region; other site 391619011707 putative PBP binding loops; other site 391619011708 ABC-ATPase subunit interface; other site 391619011709 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391619011710 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619011711 dimer interface [polypeptide binding]; other site 391619011712 conserved gate region; other site 391619011713 putative PBP binding loops; other site 391619011714 ABC-ATPase subunit interface; other site 391619011715 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498 391619011716 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 391619011717 Protein of unknown function (DUF995); Region: DUF995; pfam06191 391619011718 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 391619011719 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391619011720 Walker A motif; other site 391619011721 ATP binding site [chemical binding]; other site 391619011722 Walker B motif; other site 391619011723 arginine finger; other site 391619011724 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391619011725 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 391619011726 DNA binding residues [nucleotide binding] 391619011727 Integrase core domain; Region: rve; pfam00665 391619011728 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 391619011729 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 391619011730 putative dimer interface [polypeptide binding]; other site 391619011731 N-terminal domain interface [polypeptide binding]; other site 391619011732 putative substrate binding pocket (H-site) [chemical binding]; other site 391619011733 Domain of unknown function (DUF4347); Region: DUF4347; pfam14252 391619011734 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 391619011735 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 391619011736 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 391619011737 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 391619011738 NnrS protein; Region: NnrS; pfam05940 391619011739 Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548 391619011740 norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454 391619011741 metal ion-dependent adhesion site (MIDAS); other site 391619011742 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391619011743 MoxR-like ATPases [General function prediction only]; Region: COG0714 391619011744 Walker A motif; other site 391619011745 ATP binding site [chemical binding]; other site 391619011746 Walker B motif; other site 391619011747 CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406 391619011748 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 391619011749 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 391619011750 Putative water exit pathway; other site 391619011751 Binuclear center (active site) [active] 391619011752 K-pathway; other site 391619011753 Putative proton exit pathway; other site 391619011754 Cytochrome c; Region: Cytochrom_C; pfam00034 391619011755 hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980 391619011756 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 391619011757 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 391619011758 ligand binding site [chemical binding]; other site 391619011759 flexible hinge region; other site 391619011760 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 391619011761 putative switch regulator; other site 391619011762 non-specific DNA interactions [nucleotide binding]; other site 391619011763 DNA binding site [nucleotide binding] 391619011764 sequence specific DNA binding site [nucleotide binding]; other site 391619011765 putative cAMP binding site [chemical binding]; other site 391619011766 nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376 391619011767 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 391619011768 Multicopper oxidase; Region: Cu-oxidase; pfam00394 391619011769 Uncharacterized conserved protein [Function unknown]; Region: COG1262 391619011770 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 391619011771 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391619011772 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391619011773 Helix-turn-helix domain; Region: HTH_18; pfam12833 391619011774 Cupin domain; Region: Cupin_2; pfam07883 391619011775 Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072 391619011776 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 391619011777 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 391619011778 MOSC domain; Region: MOSC; pfam03473 391619011779 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 391619011780 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 391619011781 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 391619011782 FMN-binding pocket [chemical binding]; other site 391619011783 flavin binding motif; other site 391619011784 phosphate binding motif [ion binding]; other site 391619011785 beta-alpha-beta structure motif; other site 391619011786 NAD binding pocket [chemical binding]; other site 391619011787 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 391619011788 catalytic loop [active] 391619011789 iron binding site [ion binding]; other site 391619011790 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 391619011791 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391619011792 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391619011793 dimerization interface [polypeptide binding]; other site 391619011794 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 391619011795 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 391619011796 [2Fe-2S] cluster binding site [ion binding]; other site 391619011797 C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680 391619011798 alpha subunit interface [polypeptide binding]; other site 391619011799 active site 391619011800 substrate binding site [chemical binding]; other site 391619011801 Fe binding site [ion binding]; other site 391619011802 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 391619011803 Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109 391619011804 NAD(P) binding site [chemical binding]; other site 391619011805 catalytic residues [active] 391619011806 catalytic residues [active] 391619011807 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391619011808 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391619011809 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 391619011810 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 391619011811 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391619011812 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 391619011813 Protein of unknown function (DUF3726); Region: DUF3726; pfam12525 391619011814 BCCT family transporter; Region: BCCT; pfam02028 391619011815 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391619011816 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 391619011817 active site 391619011818 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 391619011819 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391619011820 NAD(P) binding site [chemical binding]; other site 391619011821 catalytic residues [active] 391619011822 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391619011823 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391619011824 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 391619011825 putative dimerization interface [polypeptide binding]; other site 391619011826 Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977 391619011827 AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136 391619011828 conserved cys residue [active] 391619011829 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391619011830 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391619011831 Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893 391619011832 sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372 391619011833 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510 391619011834 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391619011835 Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267 391619011836 sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373 391619011837 hydroxyglutarate oxidase; Provisional; Region: PRK11728 391619011838 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 391619011839 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 391619011840 DNA-binding site [nucleotide binding]; DNA binding site 391619011841 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391619011842 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391619011843 homodimer interface [polypeptide binding]; other site 391619011844 catalytic residue [active] 391619011845 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 391619011846 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391619011847 substrate binding site [chemical binding]; other site 391619011848 oxyanion hole (OAH) forming residues; other site 391619011849 trimer interface [polypeptide binding]; other site 391619011850 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 391619011851 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391619011852 active site 391619011853 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 391619011854 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 391619011855 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 391619011856 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391619011857 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 391619011858 Predicted transcriptional regulators [Transcription]; Region: COG1695 391619011859 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 391619011860 metal binding site 2 [ion binding]; metal-binding site 391619011861 putative DNA binding helix; other site 391619011862 dimer interface [polypeptide binding]; other site 391619011863 structural Zn2+ binding site [ion binding]; other site 391619011864 metal binding site 1 [ion binding]; metal-binding site 391619011865 Protein of unknown function (DUF2796); Region: DUF2796; pfam10986 391619011866 Protein of unknown function (DUF2796); Region: DUF2796; pfam10986 391619011867 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 391619011868 putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608 391619011869 Walker A/P-loop; other site 391619011870 ATP binding site [chemical binding]; other site 391619011871 Q-loop/lid; other site 391619011872 ABC transporter signature motif; other site 391619011873 Walker B; other site 391619011874 D-loop; other site 391619011875 H-loop/switch region; other site 391619011876 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 391619011877 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 391619011878 FtsX-like permease family; Region: FtsX; pfam02687 391619011879 Protein of unknown function (DUF3299); Region: DUF3299; pfam11736 391619011880 transposase/IS protein; Provisional; Region: PRK09183 391619011881 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391619011882 Walker A motif; other site 391619011883 ATP binding site [chemical binding]; other site 391619011884 Walker B motif; other site 391619011885 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391619011886 Integrase core domain; Region: rve; pfam00665 391619011887 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391619011888 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391619011889 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391619011890 dimerization interface [polypeptide binding]; other site 391619011891 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 391619011892 non-specific DNA binding site [nucleotide binding]; other site 391619011893 salt bridge; other site 391619011894 sequence-specific DNA binding site [nucleotide binding]; other site 391619011895 X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129 391619011896 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 391619011897 X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939 391619011898 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 391619011899 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 391619011900 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 391619011901 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619011902 dimer interface [polypeptide binding]; other site 391619011903 conserved gate region; other site 391619011904 putative PBP binding loops; other site 391619011905 ABC-ATPase subunit interface; other site 391619011906 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 391619011907 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619011908 dimer interface [polypeptide binding]; other site 391619011909 conserved gate region; other site 391619011910 putative PBP binding loops; other site 391619011911 ABC-ATPase subunit interface; other site 391619011912 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 391619011913 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391619011914 Walker A/P-loop; other site 391619011915 ATP binding site [chemical binding]; other site 391619011916 Q-loop/lid; other site 391619011917 ABC transporter signature motif; other site 391619011918 Walker B; other site 391619011919 D-loop; other site 391619011920 H-loop/switch region; other site 391619011921 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 391619011922 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 391619011923 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 391619011924 Walker A/P-loop; other site 391619011925 ATP binding site [chemical binding]; other site 391619011926 Q-loop/lid; other site 391619011927 ABC transporter signature motif; other site 391619011928 Walker B; other site 391619011929 D-loop; other site 391619011930 H-loop/switch region; other site 391619011931 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 391619011932 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 391619011933 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 391619011934 active site 391619011935 Epoxide hydrolase N terminus; Region: EHN; pfam06441 391619011936 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 391619011937 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 391619011938 homotrimer interaction site [polypeptide binding]; other site 391619011939 putative active site [active] 391619011940 Transcriptional regulator [Transcription]; Region: LysR; COG0583 391619011941 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391619011942 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 391619011943 putative dimerization interface [polypeptide binding]; other site 391619011944 Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097 391619011945 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 391619011946 NAD(P) binding site [chemical binding]; other site 391619011947 catalytic residues [active] 391619011948 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 391619011949 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 391619011950 active site 391619011951 Protein of unknown function (DUF3726); Region: DUF3726; pfam12525 391619011952 putative dimethyl sulfoniopropionate demethylase; Reviewed; Region: dmdA; PRK12486 391619011953 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 391619011954 acyl-CoA synthetase; Validated; Region: PRK08162 391619011955 Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118 391619011956 acyl-activating enzyme (AAE) consensus motif; other site 391619011957 putative active site [active] 391619011958 AMP binding site [chemical binding]; other site 391619011959 putative CoA binding site [chemical binding]; other site 391619011960 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 391619011961 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391619011962 substrate binding site [chemical binding]; other site 391619011963 oxyanion hole (OAH) forming residues; other site 391619011964 trimer interface [polypeptide binding]; other site 391619011965 acyl-CoA dehydrogenase; Provisional; Region: PTZ00456 391619011966 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 391619011967 active site 391619011968 Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806 391619011969 Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625 391619011970 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 391619011971 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 391619011972 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 391619011973 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 391619011974 active site pocket [active] 391619011975 Old yellow enzyme (OYE)-related FMN binding domain, group 2. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_2_FMN; cd04733 391619011976 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 391619011977 putative active site [active] 391619011978 putative FMN binding site [chemical binding]; other site 391619011979 putative substrate binding site [chemical binding]; other site 391619011980 putative catalytic residue [active] 391619011981 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 391619011982 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 391619011983 phosphate binding site [ion binding]; other site 391619011984 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 391619011985 dimerization interface [polypeptide binding]; other site 391619011986 putative DNA binding site [nucleotide binding]; other site 391619011987 putative Zn2+ binding site [ion binding]; other site 391619011988 Uncharacterized conserved protein [Function unknown]; Region: COG2128 391619011989 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391619011990 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391619011991 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 391619011992 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391619011993 enoyl-CoA hydratase; Provisional; Region: PRK05980 391619011994 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 391619011995 substrate binding site [chemical binding]; other site 391619011996 oxyanion hole (OAH) forming residues; other site 391619011997 trimer interface [polypeptide binding]; other site 391619011998 Predicted permease; Region: DUF318; cl17795 391619011999 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 391619012000 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 391619012001 dimerization interface [polypeptide binding]; other site 391619012002 alkylhydroperoxidase AhpD family core domain; Region: ahpD_dom; TIGR00778 391619012003 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391619012004 Integrase core domain; Region: rve; pfam00665 391619012005 transposase/IS protein; Provisional; Region: PRK09183 391619012006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391619012007 Walker A motif; other site 391619012008 ATP binding site [chemical binding]; other site 391619012009 Walker B motif; other site 391619012010 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 391619012011 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 391619012012 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 391619012013 Walker A motif; other site 391619012014 ATP binding site [chemical binding]; other site 391619012015 Walker B motif; other site 391619012016 arginine finger; other site 391619012017 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 391619012018 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 391619012019 DNA binding residues [nucleotide binding] 391619012020 Integrase core domain; Region: rve; pfam00665 391619012021 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 391619012022 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391619012023 active site 391619012024 phosphorylation site [posttranslational modification] 391619012025 intermolecular recognition site; other site 391619012026 dimerization interface [polypeptide binding]; other site 391619012027 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 391619012028 Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138 391619012029 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 391619012030 S-adenosylmethionine binding site [chemical binding]; other site 391619012031 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 391619012032 putative CheA interaction surface; other site 391619012033 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 391619012034 putative binding surface; other site 391619012035 active site 391619012036 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 391619012037 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 391619012038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391619012039 ATP binding site [chemical binding]; other site 391619012040 Mg2+ binding site [ion binding]; other site 391619012041 G-X-G motif; other site 391619012042 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 391619012043 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 391619012044 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391619012045 active site 391619012046 phosphorylation site [posttranslational modification] 391619012047 intermolecular recognition site; other site 391619012048 dimerization interface [polypeptide binding]; other site 391619012049 STAS domain; Region: STAS_2; pfam13466 391619012050 Cache domain; Region: Cache_1; pfam02743 391619012051 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 391619012052 dimerization interface [polypeptide binding]; other site 391619012053 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 391619012054 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 391619012055 dimer interface [polypeptide binding]; other site 391619012056 putative CheW interface [polypeptide binding]; other site 391619012057 CheB methylesterase; Region: CheB_methylest; pfam01339 391619012058 CheD chemotactic sensory transduction; Region: CheD; cl00810 391619012059 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 391619012060 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 391619012061 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 391619012062 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619012063 putative PBP binding loops; other site 391619012064 dimer interface [polypeptide binding]; other site 391619012065 ABC-ATPase subunit interface; other site 391619012066 ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148 391619012067 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 391619012068 Walker A/P-loop; other site 391619012069 ATP binding site [chemical binding]; other site 391619012070 Q-loop/lid; other site 391619012071 ABC transporter signature motif; other site 391619012072 Walker B; other site 391619012073 D-loop; other site 391619012074 H-loop/switch region; other site 391619012075 TOBE domain; Region: TOBE; pfam03459 391619012076 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 391619012077 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 391619012078 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 391619012079 intersubunit interface [polypeptide binding]; other site 391619012080 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 391619012081 metal binding site [ion binding]; metal-binding site 391619012082 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326 391619012083 metal binding site 2 [ion binding]; metal-binding site 391619012084 putative DNA binding helix; other site 391619012085 metal binding site 1 [ion binding]; metal-binding site 391619012086 dimer interface [polypeptide binding]; other site 391619012087 structural Zn2+ binding site [ion binding]; other site 391619012088 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 391619012089 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 391619012090 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 391619012091 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 391619012092 ABC-ATPase subunit interface; other site 391619012093 dimer interface [polypeptide binding]; other site 391619012094 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 391619012095 dimer interface [polypeptide binding]; other site 391619012096 phosphorylation site [posttranslational modification] 391619012097 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 391619012098 ATP binding site [chemical binding]; other site 391619012099 Mg2+ binding site [ion binding]; other site 391619012100 G-X-G motif; other site 391619012101 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 391619012102 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391619012103 active site 391619012104 phosphorylation site [posttranslational modification] 391619012105 intermolecular recognition site; other site 391619012106 dimerization interface [polypeptide binding]; other site 391619012107 Response regulator receiver domain; Region: Response_reg; pfam00072 391619012108 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 391619012109 active site 391619012110 phosphorylation site [posttranslational modification] 391619012111 intermolecular recognition site; other site 391619012112 dimerization interface [polypeptide binding]; other site 391619012113 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 391619012114 ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974 391619012115 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 391619012116 active site residue [active] 391619012117 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 391619012118 active site residue [active] 391619012119 60Kd inner membrane protein; Region: 60KD_IMP; pfam02096 391619012120 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 391619012121 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 391619012122 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 391619012123 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 391619012124 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 391619012125 putative active site [active] 391619012126 Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182 391619012127 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 391619012128 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 391619012129 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 391619012130 Amidinotransferase; Region: Amidinotransf; cl12043 391619012131 hypothetical protein; Provisional; Region: PRK07524 391619012132 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 391619012133 PYR/PP interface [polypeptide binding]; other site 391619012134 dimer interface [polypeptide binding]; other site 391619012135 TPP binding site [chemical binding]; other site 391619012136 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 391619012137 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568 391619012138 TPP-binding site [chemical binding]; other site 391619012139 Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436 391619012140 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 391619012141 pyridoxal 5'-phosphate binding site [chemical binding]; other site 391619012142 homodimer interface [polypeptide binding]; other site 391619012143 catalytic residue [active] 391619012144 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 391619012145 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 391619012146 ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598 391619012147 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 391619012148 Walker A/P-loop; other site 391619012149 ATP binding site [chemical binding]; other site 391619012150 Q-loop/lid; other site 391619012151 ABC transporter signature motif; other site 391619012152 Walker B; other site 391619012153 D-loop; other site 391619012154 H-loop/switch region; other site 391619012155 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 391619012156 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 391619012157 substrate binding pocket [chemical binding]; other site 391619012158 membrane-bound complex binding site; other site 391619012159 hinge residues; other site 391619012160 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 391619012161 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619012162 dimer interface [polypeptide binding]; other site 391619012163 conserved gate region; other site 391619012164 putative PBP binding loops; other site 391619012165 ABC-ATPase subunit interface; other site 391619012166 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 391619012167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 391619012168 dimer interface [polypeptide binding]; other site 391619012169 conserved gate region; other site 391619012170 putative PBP binding loops; other site 391619012171 ABC-ATPase subunit interface; other site 391619012172 DnaA N-terminal domain; Region: DnaA_N; pfam11638