-- dump date   	20140619_233606
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
1423144000001	DnaA N-terminal domain; Region: DnaA_N; pfam11638
1423144000002	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
1423144000003	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1423144000004	Walker A motif; other site
1423144000005	ATP binding site [chemical binding]; other site
1423144000006	Walker B motif; other site
1423144000007	arginine finger; other site
1423144000008	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1423144000009	DnaA box-binding interface [nucleotide binding]; other site
1423144000010	DNA polymerase III subunit beta; Validated; Region: PRK05643
1423144000011	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
1423144000012	putative DNA binding surface [nucleotide binding]; other site
1423144000013	dimer interface [polypeptide binding]; other site
1423144000014	beta-clamp/clamp loader binding surface; other site
1423144000015	beta-clamp/translesion DNA polymerase binding surface; other site
1423144000016	recombination protein F; Reviewed; Region: recF; PRK00064
1423144000017	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1423144000018	Walker A/P-loop; other site
1423144000019	ATP binding site [chemical binding]; other site
1423144000020	Q-loop/lid; other site
1423144000021	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1423144000022	ABC transporter signature motif; other site
1423144000023	Walker B; other site
1423144000024	D-loop; other site
1423144000025	H-loop/switch region; other site
1423144000026	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1423144000027	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1423144000028	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1423144000029	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
1423144000030	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1423144000031	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
1423144000032	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1423144000033	Mg2+ binding site [ion binding]; other site
1423144000034	G-X-G motif; other site
1423144000035	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1423144000036	anchoring element; other site
1423144000037	dimer interface [polypeptide binding]; other site
1423144000038	ATP binding site [chemical binding]; other site
1423144000039	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
1423144000040	active site
1423144000041	putative metal-binding site [ion binding]; other site
1423144000042	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1423144000043	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1423144000044	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1423144000045	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1423144000046	substrate binding pocket [chemical binding]; other site
1423144000047	membrane-bound complex binding site; other site
1423144000048	hinge residues; other site
1423144000049	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1423144000050	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1423144000051	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1423144000052	substrate binding pocket [chemical binding]; other site
1423144000053	membrane-bound complex binding site; other site
1423144000054	hinge residues; other site
1423144000055	hypothetical protein; Provisional; Region: PRK07481
1423144000056	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1423144000057	inhibitor-cofactor binding pocket; inhibition site
1423144000058	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144000059	catalytic residue [active]
1423144000060	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1423144000061	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1423144000062	Bacterial transcriptional regulator; Region: IclR; pfam01614
1423144000063	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
1423144000064	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
1423144000065	Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970
1423144000066	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1423144000067	Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112
1423144000068	NAD(P) binding site [chemical binding]; other site
1423144000069	catalytic residues [active]
1423144000070	hypothetical protein; Provisional; Region: PRK02399
1423144000071	Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792
1423144000072	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
1423144000073	putative substrate binding pocket [chemical binding]; other site
1423144000074	trimer interface [polypeptide binding]; other site
1423144000075	5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299
1423144000076	Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093
1423144000077	NAD binding site [chemical binding]; other site
1423144000078	catalytic residues [active]
1423144000079	3,4-dihydroxyphenylacetate 2,3-dioxygenase; Region: HpaD; TIGR02295
1423144000080	N-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD); belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_N_class_II; cd07266
1423144000081	tetramer interface [polypeptide binding]; other site
1423144000082	C-terminal domain of 3,4-dihydroxyphenylacetate 2,3-dioxygenase (HPCD), which catalyses the second step in the degradation of 4-hydroxyphenylacetate to succinate and pyruvate; belongs to the type I class II family of extradiol dioxygenases; Region: HPCD_C_class_II; cd07256
1423144000083	tetramer interface [polypeptide binding]; other site
1423144000084	active site
1423144000085	metal binding site [ion binding]; metal-binding site
1423144000086	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1423144000087	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1423144000088	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
1423144000089	Hint domain; Region: Hint_2; pfam13403
1423144000090	Predicted sulfurtransferase [General function prediction only]; Region: COG1054
1423144000091	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
1423144000092	active site residue [active]
1423144000093	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
1423144000094	Isochorismatase family; Region: Isochorismatase; pfam00857
1423144000095	catalytic triad [active]
1423144000096	metal binding site [ion binding]; metal-binding site
1423144000097	conserved cis-peptide bond; other site
1423144000098	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1423144000099	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
1423144000100	putative active site [active]
1423144000101	heme pocket [chemical binding]; other site
1423144000102	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1423144000103	dimer interface [polypeptide binding]; other site
1423144000104	phosphorylation site [posttranslational modification]
1423144000105	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1423144000106	ATP binding site [chemical binding]; other site
1423144000107	Mg2+ binding site [ion binding]; other site
1423144000108	G-X-G motif; other site
1423144000109	Response regulator receiver domain; Region: Response_reg; pfam00072
1423144000110	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144000111	active site
1423144000112	phosphorylation site [posttranslational modification]
1423144000113	intermolecular recognition site; other site
1423144000114	dimerization interface [polypeptide binding]; other site
1423144000115	Nicotinic acid phosphoribosyltransferase [Coenzyme metabolism]; Region: PncB; COG1488
1423144000116	nicotinate phosphoribosyltransferase; Provisional; Region: PRK05321
1423144000117	active site
1423144000118	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1423144000119	Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109
1423144000120	NAD(P) binding site [chemical binding]; other site
1423144000121	catalytic residues [active]
1423144000122	catalytic residues [active]
1423144000123	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1423144000124	Coenzyme A binding pocket [chemical binding]; other site
1423144000125	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1423144000126	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1423144000127	Walker A/P-loop; other site
1423144000128	ATP binding site [chemical binding]; other site
1423144000129	Q-loop/lid; other site
1423144000130	ABC transporter signature motif; other site
1423144000131	Walker B; other site
1423144000132	D-loop; other site
1423144000133	H-loop/switch region; other site
1423144000134	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1423144000135	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1423144000136	Walker A/P-loop; other site
1423144000137	ATP binding site [chemical binding]; other site
1423144000138	Q-loop/lid; other site
1423144000139	ABC transporter signature motif; other site
1423144000140	Walker B; other site
1423144000141	D-loop; other site
1423144000142	H-loop/switch region; other site
1423144000143	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1423144000144	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
1423144000145	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144000146	dimer interface [polypeptide binding]; other site
1423144000147	ABC-ATPase subunit interface; other site
1423144000148	putative PBP binding loops; other site
1423144000149	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1423144000150	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144000151	dimer interface [polypeptide binding]; other site
1423144000152	conserved gate region; other site
1423144000153	putative PBP binding loops; other site
1423144000154	ABC-ATPase subunit interface; other site
1423144000155	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
1423144000156	Class I histone deacetylase AcuC (Acetoin utilization protein)-like enzymes; Region: HDAC_AcuC_like; cd09994
1423144000157	active site
1423144000158	Zn binding site [ion binding]; other site
1423144000159	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1423144000160	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_6; cd08494
1423144000161	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
1423144000162	active site
1423144000163	oligomerization interface [polypeptide binding]; other site
1423144000164	metal binding site [ion binding]; metal-binding site
1423144000165	pantoate--beta-alanine ligase; Region: panC; TIGR00018
1423144000166	Pantoate-beta-alanine ligase; Region: PanC; cd00560
1423144000167	active site
1423144000168	ATP-binding site [chemical binding]; other site
1423144000169	pantoate-binding site; other site
1423144000170	HXXH motif; other site
1423144000171	Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554
1423144000172	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
1423144000173	N- and C-terminal domain interface [polypeptide binding]; other site
1423144000174	active site
1423144000175	MgATP binding site [chemical binding]; other site
1423144000176	catalytic site [active]
1423144000177	metal binding site [ion binding]; metal-binding site
1423144000178	glycerol binding site [chemical binding]; other site
1423144000179	homotetramer interface [polypeptide binding]; other site
1423144000180	homodimer interface [polypeptide binding]; other site
1423144000181	FBP binding site [chemical binding]; other site
1423144000182	protein IIAGlc interface [polypeptide binding]; other site
1423144000183	hypothetical protein; Provisional; Region: PRK07538
1423144000184	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1423144000185	isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150
1423144000186	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
1423144000187	active site
1423144000188	metal binding site [ion binding]; metal-binding site
1423144000189	nudix motif; other site
1423144000190	Cytochrome c; Region: Cytochrom_C; cl11414
1423144000191	nylC-like family; composed of proteins with similarity to Flavobacterium endo-type 6-aminohexanoate-oligomer hydrolase (EIII), the product of the nylon oligomer degradation gene, nylC. EIII is an amide hydrolase that catalyzes the degradation of...; Region: nylC_like; cd02252
1423144000192	putative active site pocket [active]
1423144000193	cleavage site
1423144000194	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 3, classical (c) SDR; Region: BKR_3_SDR_c; cd05345
1423144000195	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231
1423144000196	putative NAD(P) binding site [chemical binding]; other site
1423144000197	active site
1423144000198	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
1423144000199	hypothetical protein; Provisional; Region: PRK09256
1423144000200	Uncharacterized ACR, YhhQ family COG1738; Region: DUF165; cl00756
1423144000201	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4246
1423144000202	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
1423144000203	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
1423144000204	Permeases of the major facilitator superfamily [General function prediction only]; Region: COG2270
1423144000205	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1423144000206	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1423144000207	active site
1423144000208	YGGT family; Region: YGGT; pfam02325
1423144000209	ATP-dependent DNA helicase RecQ; Region: recQ; TIGR01389
1423144000210	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1423144000211	ATP binding site [chemical binding]; other site
1423144000212	putative Mg++ binding site [ion binding]; other site
1423144000213	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1423144000214	nucleotide binding region [chemical binding]; other site
1423144000215	ATP-binding site [chemical binding]; other site
1423144000216	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
1423144000217	HRDC domain; Region: HRDC; pfam00570
1423144000218	hypothetical protein; Validated; Region: PRK02101
1423144000219	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1423144000220	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1423144000221	dimer interface [polypeptide binding]; other site
1423144000222	phosphorylation site [posttranslational modification]
1423144000223	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1423144000224	ATP binding site [chemical binding]; other site
1423144000225	Mg2+ binding site [ion binding]; other site
1423144000226	G-X-G motif; other site
1423144000227	Response regulator receiver domain; Region: Response_reg; pfam00072
1423144000228	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144000229	active site
1423144000230	phosphorylation site [posttranslational modification]
1423144000231	intermolecular recognition site; other site
1423144000232	dimerization interface [polypeptide binding]; other site
1423144000233	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1423144000234	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144000235	active site
1423144000236	phosphorylation site [posttranslational modification]
1423144000237	intermolecular recognition site; other site
1423144000238	dimerization interface [polypeptide binding]; other site
1423144000239	Subfamily of PAN/APPLE-like domains; present in plasma prekallikrein/coagulation factor XI, microneme antigen proteins, and a few prokaryotic proteins. PAN/APPLE domains fulfill diverse biological functions by mediating protein-protein or...; Region: APPLE_Factor_XI_like; cd01100
1423144000240	putative binding site; other site
1423144000241	Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373
1423144000242	MG2 domain; Region: A2M_N; pfam01835
1423144000243	Alpha-2-macroglobulin family; Region: A2M; pfam00207
1423144000244	Proteins similar to alpha2-macroglobulin (alpha (2)-M).  Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor.  The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891
1423144000245	surface patch; other site
1423144000246	thioester region; other site
1423144000247	specificity defining residues; other site
1423144000248	Transglycosylase; Region: Transgly; pfam00912
1423144000249	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1423144000250	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1423144000251	Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832
1423144000252	Protein of unknown function (DUF1355); Region: DUF1355; cl17712
1423144000253	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
1423144000254	Domain of unknown function (DUF4159); Region: DUF4159; pfam13709
1423144000255	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
1423144000256	Protein of unknown function DUF58; Region: DUF58; pfam01882
1423144000257	MoxR-like ATPases [General function prediction only]; Region: COG0714
1423144000258	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1423144000259	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3816
1423144000260	Protein of unknown function (DUF1285); Region: DUF1285; pfam06938
1423144000261	Hydroxypyruvate isomerase [Carbohydrate transport and metabolism]; Region: Hfi; COG3622
1423144000262	Protein of unknown function (DUF2798); Region: DUF2798; pfam11391
1423144000263	DNA polymerase I; Provisional; Region: PRK05755
1423144000264	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
1423144000265	active site
1423144000266	metal binding site 1 [ion binding]; metal-binding site
1423144000267	putative 5' ssDNA interaction site; other site
1423144000268	metal binding site 3; metal-binding site
1423144000269	metal binding site 2 [ion binding]; metal-binding site
1423144000270	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
1423144000271	putative DNA binding site [nucleotide binding]; other site
1423144000272	putative metal binding site [ion binding]; other site
1423144000273	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
1423144000274	active site
1423144000275	catalytic site [active]
1423144000276	substrate binding site [chemical binding]; other site
1423144000277	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
1423144000278	active site
1423144000279	DNA binding site [nucleotide binding]
1423144000280	catalytic site [active]
1423144000281	MHYT domain (predicted integral membrane sensor domain) [Signal transduction mechanisms]; Region: COG3300
1423144000282	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
1423144000283	Bacterial signalling protein N terminal repeat; Region: MHYT; pfam03707
1423144000284	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1423144000285	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1423144000286	metal binding site [ion binding]; metal-binding site
1423144000287	active site
1423144000288	I-site; other site
1423144000289	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1423144000290	Zinc-finger domain; Region: zf-CHCC; pfam10276
1423144000291	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1423144000292	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1423144000293	Walker A/P-loop; other site
1423144000294	ATP binding site [chemical binding]; other site
1423144000295	Q-loop/lid; other site
1423144000296	ABC transporter signature motif; other site
1423144000297	Walker B; other site
1423144000298	D-loop; other site
1423144000299	H-loop/switch region; other site
1423144000300	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1423144000301	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1423144000302	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1423144000303	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1423144000304	Walker A/P-loop; other site
1423144000305	ATP binding site [chemical binding]; other site
1423144000306	Q-loop/lid; other site
1423144000307	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1423144000308	ABC transporter signature motif; other site
1423144000309	Walker B; other site
1423144000310	D-loop; other site
1423144000311	H-loop/switch region; other site
1423144000312	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1423144000313	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1423144000314	ligand binding site [chemical binding]; other site
1423144000315	flexible hinge region; other site
1423144000316	CAAX protease self-immunity; Region: Abi; pfam02517
1423144000317	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
1423144000318	RNA polymerases M/15 Kd subunit; Region: RNA_POL_M_15KD; cl02717
1423144000319	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1423144000320	Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285
1423144000321	Predicted ATPase [General function prediction only]; Region: COG1485
1423144000322	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1423144000323	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1423144000324	putative substrate translocation pore; other site
1423144000325	ornithine cyclodeaminase; Validated; Region: PRK06141
1423144000326	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1423144000327	NAD(P) binding site [chemical binding]; other site
1423144000328	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
1423144000329	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1423144000330	motif II; other site
1423144000331	EamA-like transporter family; Region: EamA; pfam00892
1423144000332	EamA-like transporter family; Region: EamA; cl17759
1423144000333	hypothetical protein; Validated; Region: PRK00124
1423144000334	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
1423144000335	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1423144000336	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1423144000337	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1423144000338	S-formylglutathione hydrolase; Region: PLN02442
1423144000339	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
1423144000340	Predicted permeases [General function prediction only]; Region: COG0679
1423144000341	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1423144000342	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1423144000343	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
1423144000344	Cytochrome C' Region: Cytochrom_C_2; pfam01322
1423144000345	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1423144000346	dimerization interface [polypeptide binding]; other site
1423144000347	putative DNA binding site [nucleotide binding]; other site
1423144000348	putative Zn2+ binding site [ion binding]; other site
1423144000349	Protein of unknown function (DUF2794); Region: DUF2794; pfam10984
1423144000350	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1423144000351	NlpC/P60 family; Region: NLPC_P60; pfam00877
1423144000352	Leucyl aminopeptidase [Amino acid transport and metabolism]; Region: PepB; COG0260
1423144000353	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1423144000354	interface (dimer of trimers) [polypeptide binding]; other site
1423144000355	Substrate-binding/catalytic site; other site
1423144000356	Zn-binding sites [ion binding]; other site
1423144000357	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884
1423144000358	active site clefts [active]
1423144000359	zinc binding site [ion binding]; other site
1423144000360	dimer interface [polypeptide binding]; other site
1423144000361	Protein of unknown function (DUF3095); Region: DUF3095; pfam11294
1423144000362	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1423144000363	putative substrate translocation pore; other site
1423144000364	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1423144000365	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
1423144000366	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1423144000367	conserved hypothetical protein; Region: TIGR02231
1423144000368	N-terminal domain of unknown function (DUF4140); Region: DUF4140; pfam13600
1423144000369	Domain of unknown function (DUF4139); Region: DUF4139; pfam13598
1423144000370	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1423144000371	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1423144000372	TM-ABC transporter signature motif; other site
1423144000373	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1423144000374	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1423144000375	TM-ABC transporter signature motif; other site
1423144000376	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1423144000377	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1423144000378	Walker A/P-loop; other site
1423144000379	ATP binding site [chemical binding]; other site
1423144000380	Q-loop/lid; other site
1423144000381	ABC transporter signature motif; other site
1423144000382	Walker B; other site
1423144000383	D-loop; other site
1423144000384	H-loop/switch region; other site
1423144000385	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1423144000386	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1423144000387	Walker A/P-loop; other site
1423144000388	ATP binding site [chemical binding]; other site
1423144000389	Q-loop/lid; other site
1423144000390	ABC transporter signature motif; other site
1423144000391	Walker B; other site
1423144000392	D-loop; other site
1423144000393	H-loop/switch region; other site
1423144000394	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1423144000395	Periplasmic solute-binding domain of active transport proteins found in gram-negative and gram-positive bacteria; Region: PBP1_SBP_like_2; cd06328
1423144000396	putative ligand binding site [chemical binding]; other site
1423144000397	2,4-dihydroxyhept-2-ene-1,7-dioic acid aldolase [Carbohydrate transport and metabolism]; Region: HpcH; COG3836
1423144000398	tyrosine decarboxylase; Region: PLN02880
1423144000399	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1423144000400	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1423144000401	catalytic residue [active]
1423144000402	MarR family; Region: MarR_2; cl17246
1423144000403	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1423144000404	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
1423144000405	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
1423144000406	MOFRL family; Region: MOFRL; pfam05161
1423144000407	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1423144000408	Sulfatase; Region: Sulfatase; cl17466
1423144000409	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1423144000410	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1423144000411	DNA-binding site [nucleotide binding]; DNA binding site
1423144000412	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1423144000413	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
1423144000414	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1423144000415	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
1423144000416	phosphonate utilization associated putative membrane protein; Region: phn_DUF6; TIGR03340
1423144000417	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
1423144000418	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
1423144000419	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1423144000420	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1423144000421	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1423144000422	Walker A/P-loop; other site
1423144000423	ATP binding site [chemical binding]; other site
1423144000424	Q-loop/lid; other site
1423144000425	ABC transporter signature motif; other site
1423144000426	Walker B; other site
1423144000427	D-loop; other site
1423144000428	H-loop/switch region; other site
1423144000429	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144000430	dimer interface [polypeptide binding]; other site
1423144000431	conserved gate region; other site
1423144000432	putative PBP binding loops; other site
1423144000433	ABC-ATPase subunit interface; other site
1423144000434	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1423144000435	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144000436	dimer interface [polypeptide binding]; other site
1423144000437	conserved gate region; other site
1423144000438	putative PBP binding loops; other site
1423144000439	ABC-ATPase subunit interface; other site
1423144000440	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
1423144000441	active site
1423144000442	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
1423144000443	Catalytic NodB homology domain of uncharacterized bacterial glycosyl transferase, group 2-like family proteins; Region: CE4_GT2-like; cd10962
1423144000444	NodB motif; other site
1423144000445	putative active site [active]
1423144000446	putative catalytic site [active]
1423144000447	putative Zn binding site [ion binding]; other site
1423144000448	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1423144000449	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
1423144000450	DXD motif; other site
1423144000451	Protein of unknown function (DUF3131); Region: DUF3131; pfam11329
1423144000452	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
1423144000453	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
1423144000454	hinge; other site
1423144000455	active site
1423144000456	Protein of unknown function (DUF2948); Region: DUF2948; pfam11164
1423144000457	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1423144000458	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1423144000459	Coenzyme A binding pocket [chemical binding]; other site
1423144000460	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
1423144000461	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1423144000462	NAD binding site [chemical binding]; other site
1423144000463	dimerization interface [polypeptide binding]; other site
1423144000464	product binding site; other site
1423144000465	substrate binding site [chemical binding]; other site
1423144000466	zinc binding site [ion binding]; other site
1423144000467	catalytic residues [active]
1423144000468	hypothetical protein; Provisional; Region: PRK02853
1423144000469	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1423144000470	Low molecular weight phosphatase family; Region: LMWPc; cl00105
1423144000471	active site
1423144000472	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1423144000473	MjaII restriction endonuclease; Region: RE_MjaII; pfam09520
1423144000474	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1423144000475	Coenzyme A binding pocket [chemical binding]; other site
1423144000476	Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574
1423144000477	Predicted amidohydrolase [General function prediction only]; Region: COG0388
1423144000478	putative active site [active]
1423144000479	catalytic triad [active]
1423144000480	putative dimer interface [polypeptide binding]; other site
1423144000481	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
1423144000482	rRNA binding site [nucleotide binding]; other site
1423144000483	predicted 30S ribosome binding site; other site
1423144000484	Maf-like protein; Region: Maf; pfam02545
1423144000485	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1423144000486	active site
1423144000487	dimer interface [polypeptide binding]; other site
1423144000488	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
1423144000489	Domain of unknown function (DUF329); Region: DUF329; pfam03884
1423144000490	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1423144000491	active site
1423144000492	catalytic residues [active]
1423144000493	DNA binding site [nucleotide binding]
1423144000494	Int/Topo IB signature motif; other site
1423144000495	Helix-turn-helix domain; Region: HTH_17; pfam12728
1423144000496	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
1423144000497	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
1423144000498	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
1423144000499	active site
1423144000500	metal binding site [ion binding]; metal-binding site
1423144000501	AAA domain; Region: AAA_14; pfam13173
1423144000502	Phytochrome region; Region: PHY; pfam00360
1423144000503	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1423144000504	Helix-turn-helix domain; Region: HTH_36; pfam13730
1423144000505	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1423144000506	Transposase DDE domain; Region: DDE_Tnp_1_3; pfam13612
1423144000507	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1423144000508	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1423144000509	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1423144000510	dimerization interface [polypeptide binding]; other site
1423144000511	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
1423144000512	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1423144000513	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
1423144000514	ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125
1423144000515	Walker A/P-loop; other site
1423144000516	ATP binding site [chemical binding]; other site
1423144000517	Q-loop/lid; other site
1423144000518	ABC transporter signature motif; other site
1423144000519	Walker B; other site
1423144000520	D-loop; other site
1423144000521	H-loop/switch region; other site
1423144000522	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144000523	dimer interface [polypeptide binding]; other site
1423144000524	conserved gate region; other site
1423144000525	ABC-ATPase subunit interface; other site
1423144000526	Arginase-like and histone-like hydrolases; Region: Arginase_HDAC; cl17011
1423144000527	agmatinase; Region: agmatinase; TIGR01230
1423144000528	active site
1423144000529	metal binding site [ion binding]; metal-binding site
1423144000530	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
1423144000531	agmatinase; Region: agmatinase; TIGR01230
1423144000532	oligomer interface [polypeptide binding]; other site
1423144000533	putative active site [active]
1423144000534	Mn binding site [ion binding]; other site
1423144000535	error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672
1423144000536	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434
1423144000537	putative active site [active]
1423144000538	putative PHP Thumb interface [polypeptide binding]; other site
1423144000539	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1423144000540	generic binding surface I; other site
1423144000541	generic binding surface II; other site
1423144000542	DNA Polymerase Y-family; Region: PolY_like; cd03468
1423144000543	active site
1423144000544	Nucleotidyltransferase/DNA polymerase involved in DNA repair [DNA replication, recombination, and repair]; Region: DinP; COG0389
1423144000545	DNA binding site [nucleotide binding]
1423144000546	Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046
1423144000547	Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244
1423144000548	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
1423144000549	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1423144000550	FeS/SAM binding site; other site
1423144000551	HemN C-terminal domain; Region: HemN_C; pfam06969
1423144000552	NnrU protein; Region: NnrU; pfam07298
1423144000553	maleylacetoacetate isomerase; Region: maiA; TIGR01262
1423144000554	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
1423144000555	C-terminal domain interface [polypeptide binding]; other site
1423144000556	GSH binding site (G-site) [chemical binding]; other site
1423144000557	putative dimer interface [polypeptide binding]; other site
1423144000558	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1423144000559	N-terminal domain interface [polypeptide binding]; other site
1423144000560	dimer interface [polypeptide binding]; other site
1423144000561	substrate binding pocket (H-site) [chemical binding]; other site
1423144000562	N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346
1423144000563	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1423144000564	Zn binding site [ion binding]; other site
1423144000565	Protein of unknown function (DUF2783); Region: DUF2783; pfam10932
1423144000566	FAD-dependent oxidoreductase; Provisional; Region: PRK08132
1423144000567	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1423144000568	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1423144000569	fumarylacetoacetase; Region: PLN02856
1423144000570	Domain of unknown function (DUF1969); Region: DUF1969; pfam09298
1423144000571	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1423144000572	homogentisate 1,2-dioxygenase; Provisional; Region: PRK05341
1423144000573	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1423144000574	MarR family; Region: MarR_2; pfam12802
1423144000575	MarR family; Region: MarR_2; cl17246
1423144000576	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1423144000577	cyclase homology domain; Region: CHD; cd07302
1423144000578	nucleotidyl binding site; other site
1423144000579	metal binding site [ion binding]; metal-binding site
1423144000580	dimer interface [polypeptide binding]; other site
1423144000581	exosortase E/protease, VPEID-CTERM system; Region: exo_VPEID; TIGR04162
1423144000582	exosortase/archaeosortase family protein; Region: exo_archaeo; TIGR04178
1423144000583	CAAX protease self-immunity; Region: Abi; cl00558
1423144000584	ATPase MipZ; Region: MipZ; pfam09140
1423144000585	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1423144000586	P-loop; other site
1423144000587	Magnesium ion binding site [ion binding]; other site
1423144000588	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00528
1423144000589	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
1423144000590	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
1423144000591	serine/threonine protein kinase; Provisional; Region: PRK14879
1423144000592	RimM N-terminal domain; Region: RimM; pfam01782
1423144000593	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK13828
1423144000594	PRC-barrel domain; Region: PRC; pfam05239
1423144000595	Subfamily of the nitroreductase family that includes BluB protein in Rhodobacter capsulatus is involved in the conversion of cobinamide to cobalamin in Cobalamin (vitamin B12) biosynthesis. Nitroreductases typically reduce their substrates by using NAD(P)...; Region: BluB; cd02145
1423144000596	putative FMN binding site [chemical binding]; other site
1423144000597	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
1423144000598	chorismate mutase; Provisional; Region: PRK09239
1423144000599	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1423144000600	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1423144000601	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1423144000602	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1423144000603	signal recognition particle protein; Provisional; Region: PRK10867
1423144000604	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
1423144000605	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1423144000606	P loop; other site
1423144000607	GTP binding site [chemical binding]; other site
1423144000608	Signal peptide binding domain; Region: SRP_SPB; pfam02978
1423144000609	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
1423144000610	elongation factor G; Reviewed; Region: PRK12740
1423144000611	G1 box; other site
1423144000612	GTP/Mg2+ binding site [chemical binding]; other site
1423144000613	G2 box; other site
1423144000614	Switch I region; other site
1423144000615	G3 box; other site
1423144000616	Switch II region; other site
1423144000617	G4 box; other site
1423144000618	G5 box; other site
1423144000619	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1423144000620	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1423144000621	This CD includes bacterial (Agrobacterium tumefaciens and Caulobacter crescentus ProX, and Clostridium sticklandii PrdX) and eukaryotic (Plasmodium falciparum N-terminal ProRS editing domain) sequences. The C. sticklandii PrdX protein, a homolog of the...; Region: PrdX_deacylase; cd04335
1423144000622	putative deacylase active site [active]
1423144000623	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1423144000624	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144000625	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1423144000626	dimerization interface [polypeptide binding]; other site
1423144000627	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1423144000628	EamA-like transporter family; Region: EamA; pfam00892
1423144000629	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1423144000630	dimerization interface [polypeptide binding]; other site
1423144000631	putative DNA binding site [nucleotide binding]; other site
1423144000632	putative Zn2+ binding site [ion binding]; other site
1423144000633	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1423144000634	EamA-like transporter family; Region: EamA; pfam00892
1423144000635	EamA-like transporter family; Region: EamA; pfam00892
1423144000636	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5336
1423144000637	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
1423144000638	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
1423144000639	F0F1 ATP synthase subunit C; Validated; Region: PRK07558
1423144000640	F0F1 ATP synthase subunit B'; Provisional; Region: PRK13454
1423144000641	F0F1 ATP synthase subunit B; Provisional; Region: PRK13455
1423144000642	F0F1 ATP synthase subunit B; Provisional; Region: PRK14475
1423144000643	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
1423144000644	putative trimer interface [polypeptide binding]; other site
1423144000645	putative CoA binding site [chemical binding]; other site
1423144000646	WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358
1423144000647	putative trimer interface [polypeptide binding]; other site
1423144000648	putative active site [active]
1423144000649	putative substrate binding site [chemical binding]; other site
1423144000650	putative CoA binding site [chemical binding]; other site
1423144000651	transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464
1423144000652	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1423144000653	DNA-binding site [nucleotide binding]; DNA binding site
1423144000654	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1423144000655	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1423144000656	AAA domain; Region: AAA_23; pfam13476
1423144000657	Walker A/P-loop; other site
1423144000658	ATP binding site [chemical binding]; other site
1423144000659	ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278
1423144000660	Walker B; other site
1423144000661	D-loop; other site
1423144000662	H-loop/switch region; other site
1423144000663	Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722
1423144000664	Transglycosylase SLT domain; Region: SLT_2; pfam13406
1423144000665	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1423144000666	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1423144000667	catalytic residue [active]
1423144000668	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1423144000669	CobD/Cbib protein; Region: CobD_Cbib; pfam03186
1423144000670	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1423144000671	L-threonine-O-3-phosphate decarboxylase; Region: L_thr_O3P_dcar; TIGR01140
1423144000672	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1423144000673	catalytic residue [active]
1423144000674	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
1423144000675	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
1423144000676	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
1423144000677	putative dimer interface [polypeptide binding]; other site
1423144000678	N-terminal domain interface [polypeptide binding]; other site
1423144000679	putative substrate binding pocket (H-site) [chemical binding]; other site
1423144000680	UvsW helicase; Provisional; Region: uvsW; PHA02558
1423144000681	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
1423144000682	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1423144000683	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144000684	homodimer interface [polypeptide binding]; other site
1423144000685	catalytic residue [active]
1423144000686	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1423144000687	active site
1423144000688	catalytic residues [active]
1423144000689	metal binding site [ion binding]; metal-binding site
1423144000690	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1423144000691	active site
1423144000692	catalytic residues [active]
1423144000693	metal binding site [ion binding]; metal-binding site
1423144000694	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
1423144000695	active site
1423144000696	catalytic residues [active]
1423144000697	metal binding site [ion binding]; metal-binding site
1423144000698	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
1423144000699	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
1423144000700	putative active site [active]
1423144000701	substrate binding site [chemical binding]; other site
1423144000702	putative cosubstrate binding site; other site
1423144000703	catalytic site [active]
1423144000704	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
1423144000705	substrate binding site [chemical binding]; other site
1423144000706	Predicted membrane protein [Function unknown]; Region: COG2860
1423144000707	UPF0126 domain; Region: UPF0126; pfam03458
1423144000708	UPF0126 domain; Region: UPF0126; pfam03458
1423144000709	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
1423144000710	RNA/DNA hybrid binding site [nucleotide binding]; other site
1423144000711	active site
1423144000712	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1423144000713	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1423144000714	S-adenosylmethionine binding site [chemical binding]; other site
1423144000715	Protein of unknown function (DUF3429); Region: DUF3429; pfam11911
1423144000716	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1423144000717	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
1423144000718	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
1423144000719	Uncharacterized conserved protein [Function unknown]; Region: COG1432
1423144000720	LabA_like proteins; Region: LabA; cd10911
1423144000721	putative metal binding site [ion binding]; other site
1423144000722	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
1423144000723	catalytic center binding site [active]
1423144000724	ATP binding site [chemical binding]; other site
1423144000725	DNA-directed RNA polymerase subunit omega; Reviewed; Region: rpoZ; PRK00392
1423144000726	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
1423144000727	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1423144000728	Zn2+ binding site [ion binding]; other site
1423144000729	Mg2+ binding site [ion binding]; other site
1423144000730	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
1423144000731	synthetase active site [active]
1423144000732	NTP binding site [chemical binding]; other site
1423144000733	metal binding site [ion binding]; metal-binding site
1423144000734	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
1423144000735	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
1423144000736	Uncharacterized protein conserved in bacteria (DUF2062); Region: DUF2062; pfam09835
1423144000737	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
1423144000738	active site
1423144000739	hydrophilic channel; other site
1423144000740	dimerization interface [polypeptide binding]; other site
1423144000741	catalytic residues [active]
1423144000742	active site lid [active]
1423144000743	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
1423144000744	signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227
1423144000745	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1423144000746	Catalytic site [active]
1423144000747	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
1423144000748	ribonuclease III, bacterial; Region: RNaseIII; TIGR02191
1423144000749	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
1423144000750	dimerization interface [polypeptide binding]; other site
1423144000751	active site
1423144000752	metal binding site [ion binding]; metal-binding site
1423144000753	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
1423144000754	dsRNA binding site [nucleotide binding]; other site
1423144000755	GTPase Era; Reviewed; Region: era; PRK00089
1423144000756	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
1423144000757	G1 box; other site
1423144000758	GTP/Mg2+ binding site [chemical binding]; other site
1423144000759	Switch I region; other site
1423144000760	G2 box; other site
1423144000761	Switch II region; other site
1423144000762	G3 box; other site
1423144000763	G4 box; other site
1423144000764	G5 box; other site
1423144000765	KH domain; Region: KH_2; pfam07650
1423144000766	Protein of unknown function (DUF1491); Region: DUF1491; pfam07372
1423144000767	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
1423144000768	Recombination protein O N terminal; Region: RecO_N; pfam11967
1423144000769	Recombination protein O C terminal; Region: RecO_C; pfam02565
1423144000770	META domain; Region: META; pfam03724
1423144000771	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1423144000772	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1423144000773	active site
1423144000774	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1423144000775	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
1423144000776	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
1423144000777	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
1423144000778	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
1423144000779	active site
1423144000780	substrate-binding site [chemical binding]; other site
1423144000781	metal-binding site [ion binding]
1423144000782	ATP binding site [chemical binding]; other site
1423144000783	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1423144000784	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144000785	active site
1423144000786	phosphorylation site [posttranslational modification]
1423144000787	intermolecular recognition site; other site
1423144000788	dimerization interface [polypeptide binding]; other site
1423144000789	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1423144000790	DNA binding site [nucleotide binding]
1423144000791	Sensor N-terminal transmembrane domain; Region: Sensor_TM1; pfam13755
1423144000792	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1423144000793	HAMP domain; Region: HAMP; pfam00672
1423144000794	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1423144000795	dimer interface [polypeptide binding]; other site
1423144000796	phosphorylation site [posttranslational modification]
1423144000797	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1423144000798	ATP binding site [chemical binding]; other site
1423144000799	Mg2+ binding site [ion binding]; other site
1423144000800	G-X-G motif; other site
1423144000801	HprK/P, the bifunctional histidine-containing protein kinase/phosphatase, controls the phosphorylation state of the phosphocarrier protein HPr and regulates the utilization of carbon sources by gram-positive bacteria. It catalyzes both the ATP-dependent...; Region: HprK_C; cd01918
1423144000802	Hpr binding site; other site
1423144000803	active site
1423144000804	homohexamer subunit interaction site [polypeptide binding]; other site
1423144000805	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
1423144000806	AAA domain; Region: AAA_18; pfam13238
1423144000807	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cl00025
1423144000808	active pocket/dimerization site; other site
1423144000809	active site
1423144000810	phosphorylation site [posttranslational modification]
1423144000811	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
1423144000812	dimerization domain swap beta strand [polypeptide binding]; other site
1423144000813	regulatory protein interface [polypeptide binding]; other site
1423144000814	active site
1423144000815	regulatory phosphorylation site [posttranslational modification]; other site
1423144000816	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986
1423144000817	putative acyl-acceptor binding pocket; other site
1423144000818	3-hydroxybutyryl-CoA dehydrogenase; Validated; Region: PRK07530
1423144000819	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1423144000820	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1423144000821	Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025
1423144000822	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
1423144000823	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
1423144000824	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
1423144000825	Ligand binding site [chemical binding]; other site
1423144000826	Electron transfer flavoprotein domain; Region: ETF; pfam01012
1423144000827	Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923
1423144000828	Hypoxia induced protein conserved region; Region: HIG_1_N; pfam04588
1423144000829	short chain dehydrogenase; Provisional; Region: PRK05993
1423144000830	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
1423144000831	NADP binding site [chemical binding]; other site
1423144000832	active site
1423144000833	steroid binding site; other site
1423144000834	Bacterial SH3 domain homologues; Region: SH3b; smart00287
1423144000835	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
1423144000836	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1423144000837	CAP-like domain; other site
1423144000838	active site
1423144000839	primary dimer interface [polypeptide binding]; other site
1423144000840	elongation factor Tu; Reviewed; Region: PRK00049
1423144000841	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1423144000842	G1 box; other site
1423144000843	GEF interaction site [polypeptide binding]; other site
1423144000844	GTP/Mg2+ binding site [chemical binding]; other site
1423144000845	Switch I region; other site
1423144000846	G2 box; other site
1423144000847	G3 box; other site
1423144000848	Switch II region; other site
1423144000849	G4 box; other site
1423144000850	G5 box; other site
1423144000851	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1423144000852	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1423144000853	Antibiotic Binding Site [chemical binding]; other site
1423144000854	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983
1423144000855	putative acyl-acceptor binding pocket; other site
1423144000856	TPR repeat; Region: TPR_11; pfam13414
1423144000857	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1423144000858	binding surface
1423144000859	TPR motif; other site
1423144000860	TPR repeat; Region: TPR_11; pfam13414
1423144000861	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1423144000862	binding surface
1423144000863	TPR repeat; Region: TPR_11; pfam13414
1423144000864	TPR motif; other site
1423144000865	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK07597
1423144000866	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
1423144000867	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
1423144000868	putative homodimer interface [polypeptide binding]; other site
1423144000869	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
1423144000870	heterodimer interface [polypeptide binding]; other site
1423144000871	homodimer interface [polypeptide binding]; other site
1423144000872	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
1423144000873	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
1423144000874	23S rRNA interface [nucleotide binding]; other site
1423144000875	L7/L12 interface [polypeptide binding]; other site
1423144000876	putative thiostrepton binding site; other site
1423144000877	L25 interface [polypeptide binding]; other site
1423144000878	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
1423144000879	mRNA/rRNA interface [nucleotide binding]; other site
1423144000880	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
1423144000881	23S rRNA interface [nucleotide binding]; other site
1423144000882	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
1423144000883	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
1423144000884	core dimer interface [polypeptide binding]; other site
1423144000885	peripheral dimer interface [polypeptide binding]; other site
1423144000886	L10 interface [polypeptide binding]; other site
1423144000887	L11 interface [polypeptide binding]; other site
1423144000888	putative EF-Tu interaction site [polypeptide binding]; other site
1423144000889	putative EF-G interaction site [polypeptide binding]; other site
1423144000890	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1423144000891	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
1423144000892	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1423144000893	RPB12 interaction site [polypeptide binding]; other site
1423144000894	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
1423144000895	RPB11 interaction site [polypeptide binding]; other site
1423144000896	RPB12 interaction site [polypeptide binding]; other site
1423144000897	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
1423144000898	RPB3 interaction site [polypeptide binding]; other site
1423144000899	RPB1 interaction site [polypeptide binding]; other site
1423144000900	RPB11 interaction site [polypeptide binding]; other site
1423144000901	RPB10 interaction site [polypeptide binding]; other site
1423144000902	DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086
1423144000903	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
1423144000904	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
1423144000905	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
1423144000906	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
1423144000907	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1423144000908	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
1423144000909	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
1423144000910	Ribosomal L27 protein; Region: Ribosomal_L27; cl00359
1423144000911	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
1423144000912	DNA binding site [nucleotide binding]
1423144000913	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
1423144000914	Putative rhamnosyl transferase; Region: Rhamno_transf; pfam11316
1423144000915	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1423144000916	EamA-like transporter family; Region: EamA; pfam00892
1423144000917	Putative rhamnosyl transferase; Region: Rhamno_transf; pfam11316
1423144000918	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
1423144000919	S17 interaction site [polypeptide binding]; other site
1423144000920	S8 interaction site; other site
1423144000921	16S rRNA interaction site [nucleotide binding]; other site
1423144000922	streptomycin interaction site [chemical binding]; other site
1423144000923	23S rRNA interaction site [nucleotide binding]; other site
1423144000924	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
1423144000925	30S ribosomal protein S7; Validated; Region: PRK05302
1423144000926	elongation factor G; Reviewed; Region: PRK00007
1423144000927	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
1423144000928	G1 box; other site
1423144000929	putative GEF interaction site [polypeptide binding]; other site
1423144000930	GTP/Mg2+ binding site [chemical binding]; other site
1423144000931	Switch I region; other site
1423144000932	G2 box; other site
1423144000933	G3 box; other site
1423144000934	Switch II region; other site
1423144000935	G4 box; other site
1423144000936	G5 box; other site
1423144000937	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
1423144000938	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
1423144000939	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
1423144000940	elongation factor Tu; Reviewed; Region: PRK00049
1423144000941	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
1423144000942	G1 box; other site
1423144000943	GEF interaction site [polypeptide binding]; other site
1423144000944	GTP/Mg2+ binding site [chemical binding]; other site
1423144000945	Switch I region; other site
1423144000946	G2 box; other site
1423144000947	G3 box; other site
1423144000948	Switch II region; other site
1423144000949	G4 box; other site
1423144000950	G5 box; other site
1423144000951	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
1423144000952	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
1423144000953	Antibiotic Binding Site [chemical binding]; other site
1423144000954	Protein of unknown function (DUF4065); Region: DUF4065; pfam13274
1423144000955	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK07691
1423144000956	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
1423144000957	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
1423144000958	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
1423144000959	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
1423144000960	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
1423144000961	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
1423144000962	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
1423144000963	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
1423144000964	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
1423144000965	putative translocon binding site; other site
1423144000966	protein-rRNA interface [nucleotide binding]; other site
1423144000967	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
1423144000968	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
1423144000969	G-X-X-G motif; other site
1423144000970	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
1423144000971	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
1423144000972	23S rRNA interface [nucleotide binding]; other site
1423144000973	5S rRNA interface [nucleotide binding]; other site
1423144000974	putative antibiotic binding site [chemical binding]; other site
1423144000975	L25 interface [polypeptide binding]; other site
1423144000976	L27 interface [polypeptide binding]; other site
1423144000977	conserved hypothetical protein; Region: TIGR02466
1423144000978	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
1423144000979	23S rRNA interface [nucleotide binding]; other site
1423144000980	putative translocon interaction site; other site
1423144000981	signal recognition particle (SRP54) interaction site; other site
1423144000982	L23 interface [polypeptide binding]; other site
1423144000983	trigger factor interaction site; other site
1423144000984	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
1423144000985	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
1423144000986	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
1423144000987	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
1423144000988	RNA binding site [nucleotide binding]; other site
1423144000989	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
1423144000990	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
1423144000991	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
1423144000992	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
1423144000993	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
1423144000994	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
1423144000995	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
1423144000996	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
1423144000997	5S rRNA interface [nucleotide binding]; other site
1423144000998	23S rRNA interface [nucleotide binding]; other site
1423144000999	L5 interface [polypeptide binding]; other site
1423144001000	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
1423144001001	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
1423144001002	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
1423144001003	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
1423144001004	23S rRNA binding site [nucleotide binding]; other site
1423144001005	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1423144001006	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1423144001007	DNA-binding site [nucleotide binding]; DNA binding site
1423144001008	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1423144001009	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144001010	homodimer interface [polypeptide binding]; other site
1423144001011	catalytic residue [active]
1423144001012	EamA-like transporter family; Region: EamA; cl17759
1423144001013	Domain of unknown function (DUF1127); Region: DUF1127; pfam06568
1423144001014	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
1423144001015	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
1423144001016	SecY translocase; Region: SecY; pfam00344
1423144001017	adenylate kinase; Reviewed; Region: adk; PRK00279
1423144001018	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1423144001019	AMP-binding site [chemical binding]; other site
1423144001020	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1423144001021	Alpha operon ribosome binding protein site
1423144001022	Ribosomal protein S13 [Translation, ribosomal structure and biogenesis]; Region: RpsM; COG0099
1423144001023	30S ribosomal protein S13; Region: bact_S13; TIGR03631
1423144001024	30S ribosomal protein S11; Validated; Region: PRK05309
1423144001025	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
1423144001026	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
1423144001027	alphaNTD - beta interaction site [polypeptide binding]; other site
1423144001028	alphaNTD homodimer interface [polypeptide binding]; other site
1423144001029	alphaNTD - beta' interaction site [polypeptide binding]; other site
1423144001030	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
1423144001031	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
1423144001032	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
1423144001033	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1423144001034	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1423144001035	protein binding site [polypeptide binding]; other site
1423144001036	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1423144001037	protein binding site [polypeptide binding]; other site
1423144001038	recombination factor protein RarA; Reviewed; Region: PRK13342
1423144001039	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1423144001040	Walker A motif; other site
1423144001041	ATP binding site [chemical binding]; other site
1423144001042	Walker B motif; other site
1423144001043	arginine finger; other site
1423144001044	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
1423144001045	CrcB-like protein; Region: CRCB; cl09114
1423144001046	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1423144001047	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1423144001048	RNA binding surface [nucleotide binding]; other site
1423144001049	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1423144001050	active site
1423144001051	Eukaryotic phosphomannomutase; Region: PMM; cl17107
1423144001052	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1423144001053	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1423144001054	motif II; other site
1423144001055	ATP12 chaperone protein; Region: ATP12; cl02228
1423144001056	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
1423144001057	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1423144001058	substrate binding pocket [chemical binding]; other site
1423144001059	membrane-bound complex binding site; other site
1423144001060	hinge residues; other site
1423144001061	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
1423144001062	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1423144001063	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144001064	dimer interface [polypeptide binding]; other site
1423144001065	ABC-ATPase subunit interface; other site
1423144001066	putative PBP binding loops; other site
1423144001067	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1423144001068	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144001069	dimer interface [polypeptide binding]; other site
1423144001070	conserved gate region; other site
1423144001071	putative PBP binding loops; other site
1423144001072	ABC-ATPase subunit interface; other site
1423144001073	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1423144001074	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1423144001075	Walker A/P-loop; other site
1423144001076	ATP binding site [chemical binding]; other site
1423144001077	Q-loop/lid; other site
1423144001078	ABC transporter signature motif; other site
1423144001079	Walker B; other site
1423144001080	D-loop; other site
1423144001081	H-loop/switch region; other site
1423144001082	Protein of unknown function, DUF; Region: DUF411; cl01142
1423144001083	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1423144001084	catalytic core [active]
1423144001085	Uncharacterized Fe-S protein [Energy production and conversion]; Region: COG1600
1423144001086	redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002
1423144001087	AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250
1423144001088	feedback inhibition sensing region; other site
1423144001089	homohexameric interface [polypeptide binding]; other site
1423144001090	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
1423144001091	nucleotide binding site [chemical binding]; other site
1423144001092	N-acetyl-L-glutamate binding site [chemical binding]; other site
1423144001093	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1423144001094	classical (c) SDRs; Region: SDR_c; cd05233
1423144001095	NAD(P) binding site [chemical binding]; other site
1423144001096	active site
1423144001097	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
1423144001098	G1 box; other site
1423144001099	GTP/Mg2+ binding site [chemical binding]; other site
1423144001100	Switch I region; other site
1423144001101	G2 box; other site
1423144001102	G3 box; other site
1423144001103	Switch II region; other site
1423144001104	G4 box; other site
1423144001105	G5 box; other site
1423144001106	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
1423144001107	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
1423144001108	MOSC domain; Region: MOSC; pfam03473
1423144001109	membrane protein insertase; Provisional; Region: PRK01318
1423144001110	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
1423144001111	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1423144001112	metal binding site [ion binding]; metal-binding site
1423144001113	active site
1423144001114	I-site; other site
1423144001115	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1423144001116	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
1423144001117	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
1423144001118	Ligand Binding Site [chemical binding]; other site
1423144001119	Protein of unknown function (DUF3833); Region: DUF3833; pfam12915
1423144001120	Haemolytic domain; Region: Haemolytic; pfam01809
1423144001121	Ribonuclease P; Region: Ribonuclease_P; pfam00825
1423144001122	50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399
1423144001123	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
1423144001124	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1423144001125	mercuric reductase; Validated; Region: PRK06370
1423144001126	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1423144001127	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1423144001128	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1423144001129	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1423144001130	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
1423144001131	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1423144001132	ATP binding site [chemical binding]; other site
1423144001133	Mg2+ binding site [ion binding]; other site
1423144001134	G-X-G motif; other site
1423144001135	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1423144001136	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1423144001137	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1423144001138	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
1423144001139	Hint domain; Region: Hint_2; pfam13403
1423144001140	Protein of unknown function (FYDLN_acid); Region: FYDLN_acid; pfam09538
1423144001141	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4530
1423144001142	Protein of unknown function DUF45; Region: DUF45; pfam01863
1423144001143	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1423144001144	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1423144001145	DNA-binding site [nucleotide binding]; DNA binding site
1423144001146	FCD domain; Region: FCD; pfam07729
1423144001147	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
1423144001148	Domain of Unknown Function (DUF1206); Region: DUF1206; pfam06724
1423144001149	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
1423144001150	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
1423144001151	Helix-turn-helix domain; Region: HTH_18; pfam12833
1423144001152	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1423144001153	GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445
1423144001154	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1423144001155	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1423144001156	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1423144001157	putative DNA binding site [nucleotide binding]; other site
1423144001158	putative Zn2+ binding site [ion binding]; other site
1423144001159	AsnC family; Region: AsnC_trans_reg; pfam01037
1423144001160	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
1423144001161	Protein of unknown function (DUF1611); Region: DUF1611; pfam07755
1423144001162	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
1423144001163	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
1423144001164	active site
1423144001165	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1423144001166	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
1423144001167	homodimer interface [polypeptide binding]; other site
1423144001168	substrate-cofactor binding pocket; other site
1423144001169	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144001170	catalytic residue [active]
1423144001171	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
1423144001172	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
1423144001173	potential catalytic triad [active]
1423144001174	conserved cys residue [active]
1423144001175	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
1423144001176	Prostaglandin dehydrogenases; Region: PGDH; cd05288
1423144001177	NAD(P) binding site [chemical binding]; other site
1423144001178	substrate binding site [chemical binding]; other site
1423144001179	dimer interface [polypeptide binding]; other site
1423144001180	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1423144001181	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1423144001182	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
1423144001183	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
1423144001184	hexamer interface [polypeptide binding]; other site
1423144001185	ligand binding site [chemical binding]; other site
1423144001186	putative active site [active]
1423144001187	NAD(P) binding site [chemical binding]; other site
1423144001188	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1423144001189	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1423144001190	putative DNA binding site [nucleotide binding]; other site
1423144001191	putative Zn2+ binding site [ion binding]; other site
1423144001192	AsnC family; Region: AsnC_trans_reg; pfam01037
1423144001193	choline dehydrogenase; Validated; Region: PRK02106
1423144001194	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1423144001195	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1423144001196	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
1423144001197	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
1423144001198	rpsU-divergently transcribed protein; Region: diverge_rpsU; TIGR02396
1423144001199	COQ9; Region: COQ9; pfam08511
1423144001200	putative NAD(P)H quinone oxidoreductase, PIG3 family; Region: quinone_pig3; TIGR02824
1423144001201	PIG3 p53-inducible quinone oxidoreductase; Region: p53_inducible_oxidoreductase; cd05276
1423144001202	NAD(P) binding site [chemical binding]; other site
1423144001203	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
1423144001204	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
1423144001205	B1 nucleotide binding pocket [chemical binding]; other site
1423144001206	B2 nucleotide binding pocket [chemical binding]; other site
1423144001207	CAS motifs; other site
1423144001208	active site
1423144001209	Protein of unknown function (DUF1013); Region: DUF1013; pfam06242
1423144001210	recombination protein RecR; Reviewed; Region: recR; PRK00076
1423144001211	RecR protein; Region: RecR; pfam02132
1423144001212	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
1423144001213	putative active site [active]
1423144001214	putative metal-binding site [ion binding]; other site
1423144001215	tetramer interface [polypeptide binding]; other site
1423144001216	hypothetical protein; Validated; Region: PRK00153
1423144001217	DNA polymerase III subunits gamma and tau; Validated; Region: PRK09111
1423144001218	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1423144001219	Walker A motif; other site
1423144001220	ATP binding site [chemical binding]; other site
1423144001221	Walker B motif; other site
1423144001222	arginine finger; other site
1423144001223	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
1423144001224	DNA polymerase III gamma and tau subunits C terminal; Region: DUF3646; pfam12362
1423144001225	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
1423144001226	active site
1423144001227	Protein of unknown function (DUF1636); Region: DUF1636; cl17843
1423144001228	2',3'-cyclic-nucleotide 2'-phosphodiesterase; Region: CycNucDiestase; TIGR01390
1423144001229	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
1423144001230	active site
1423144001231	metal binding site [ion binding]; metal-binding site
1423144001232	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1423144001233	NTP pyrophosphohydrolases containing a Zn-finger, probably nucleic-acid-binding [DNA replication, recombination, and repair]; Region: NPY1; COG2816
1423144001234	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
1423144001235	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
1423144001236	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
1423144001237	putative NADH binding site [chemical binding]; other site
1423144001238	putative active site [active]
1423144001239	nudix motif; other site
1423144001240	putative metal binding site [ion binding]; other site
1423144001241	START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812
1423144001242	hydrophobic ligand binding site; other site
1423144001243	prephenate dehydratase; Provisional; Region: PRK11899
1423144001244	Prephenate dehydratase; Region: PDT; pfam00800
1423144001245	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
1423144001246	putative L-Phe binding site [chemical binding]; other site
1423144001247	Cytochrome c2 [Energy production and conversion]; Region: COG3474
1423144001248	ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166
1423144001249	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
1423144001250	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
1423144001251	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144001252	dimer interface [polypeptide binding]; other site
1423144001253	conserved gate region; other site
1423144001254	putative PBP binding loops; other site
1423144001255	ABC-ATPase subunit interface; other site
1423144001256	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
1423144001257	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144001258	dimer interface [polypeptide binding]; other site
1423144001259	conserved gate region; other site
1423144001260	putative PBP binding loops; other site
1423144001261	ABC-ATPase subunit interface; other site
1423144001262	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
1423144001263	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1423144001264	Walker A/P-loop; other site
1423144001265	ATP binding site [chemical binding]; other site
1423144001266	Q-loop/lid; other site
1423144001267	ABC transporter signature motif; other site
1423144001268	Walker B; other site
1423144001269	D-loop; other site
1423144001270	H-loop/switch region; other site
1423144001271	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1423144001272	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1423144001273	Walker A/P-loop; other site
1423144001274	ATP binding site [chemical binding]; other site
1423144001275	Q-loop/lid; other site
1423144001276	ABC transporter signature motif; other site
1423144001277	Walker B; other site
1423144001278	D-loop; other site
1423144001279	H-loop/switch region; other site
1423144001280	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1423144001281	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1423144001282	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1423144001283	ligand binding site [chemical binding]; other site
1423144001284	flexible hinge region; other site
1423144001285	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1423144001286	putative switch regulator; other site
1423144001287	non-specific DNA interactions [nucleotide binding]; other site
1423144001288	DNA binding site [nucleotide binding]
1423144001289	sequence specific DNA binding site [nucleotide binding]; other site
1423144001290	putative cAMP binding site [chemical binding]; other site
1423144001291	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1423144001292	Ligand Binding Site [chemical binding]; other site
1423144001293	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
1423144001294	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
1423144001295	Low-spin heme binding site [chemical binding]; other site
1423144001296	Putative water exit pathway; other site
1423144001297	Binuclear center (active site) [active]
1423144001298	Putative proton exit pathway; other site
1423144001299	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
1423144001300	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433
1423144001301	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
1423144001302	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
1423144001303	Cytochrome c; Region: Cytochrom_C; pfam00034
1423144001304	Cytochrome c; Region: Cytochrom_C; pfam00034
1423144001305	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1423144001306	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1423144001307	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
1423144001308	4Fe-4S binding domain; Region: Fer4_5; pfam12801
1423144001309	4Fe-4S binding domain; Region: Fer4; cl02805
1423144001310	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
1423144001311	FixH; Region: FixH; pfam05751
1423144001312	Predicted integral membrane protein linked to a cation pump [Inorganic ion transport and metabolism]; Region: COG5456
1423144001313	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1423144001314	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1423144001315	metal-binding site [ion binding]
1423144001316	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1423144001317	Soluble P-type ATPase [General function prediction only]; Region: COG4087
1423144001318	Cytochrome oxidase maturation protein cbb3-type; Region: CcoS; pfam03597
1423144001319	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1423144001320	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1423144001321	Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011
1423144001322	REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252
1423144001323	Uncharacterized conserved protein [Function unknown]; Region: COG2127
1423144001324	16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813
1423144001325	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1423144001326	S-adenosylmethionine binding site [chemical binding]; other site
1423144001327	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
1423144001328	classical (c) SDRs; Region: SDR_c; cd05233
1423144001329	NAD(P) binding site [chemical binding]; other site
1423144001330	active site
1423144001331	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
1423144001332	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
1423144001333	Uncharacterized bacterial muramidase containing a glycosyl hydrolase family 25 (GH25) catalytic domain. Endo-N-acetylmuramidases are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis...; Region: GH25_muramidase_1; cd06413
1423144001334	Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183
1423144001335	active site
1423144001336	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
1423144001337	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
1423144001338	domain interfaces; other site
1423144001339	active site
1423144001340	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
1423144001341	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
1423144001342	substrate binding site [chemical binding]; other site
1423144001343	active site
1423144001344	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1423144001345	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1423144001346	zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033
1423144001347	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1423144001348	metal-binding site [ion binding]
1423144001349	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1423144001350	haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710
1423144001351	SlyX; Region: SlyX; pfam04102
1423144001352	histidyl-tRNA synthetase; Region: hisS; TIGR00442
1423144001353	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
1423144001354	dimer interface [polypeptide binding]; other site
1423144001355	motif 1; other site
1423144001356	motif 2; other site
1423144001357	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1423144001358	active site
1423144001359	motif 3; other site
1423144001360	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
1423144001361	anticodon binding site; other site
1423144001362	ATP phosphoribosyltransferase regulatory subunit; Provisional; Region: hisZ; PRK12295
1423144001363	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1423144001364	motif 1; other site
1423144001365	dimer interface [polypeptide binding]; other site
1423144001366	active site
1423144001367	motif 2; other site
1423144001368	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1423144001369	motif 3; other site
1423144001370	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
1423144001371	ATP phosphoribosyltransferase catalytic subunit; Provisional; Region: hisG; PRK13583
1423144001372	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1423144001373	Uncharacterized conserved protein [Function unknown]; Region: COG3472
1423144001374	T5orf172 domain; Region: T5orf172; pfam10544
1423144001375	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
1423144001376	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1423144001377	ATP binding site [chemical binding]; other site
1423144001378	putative Mg++ binding site [ion binding]; other site
1423144001379	Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002
1423144001380	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1423144001381	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1423144001382	active site
1423144001383	DNA binding site [nucleotide binding]
1423144001384	Int/Topo IB signature motif; other site
1423144001385	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1423144001386	EamA-like transporter family; Region: EamA; pfam00892
1423144001387	tartrate dehydrogenase; Region: TTC; TIGR02089
1423144001388	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
1423144001389	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1423144001390	putative metal binding site [ion binding]; other site
1423144001391	Uncharacterized protein conserved in bacteria (DUF2332); Region: DUF2332; pfam10094
1423144001392	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
1423144001393	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
1423144001394	substrate binding site [chemical binding]; other site
1423144001395	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
1423144001396	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
1423144001397	substrate binding site [chemical binding]; other site
1423144001398	ligand binding site [chemical binding]; other site
1423144001399	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
1423144001400	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1423144001401	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
1423144001402	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
1423144001403	Protein of unknown function, DUF599; Region: DUF599; pfam04654
1423144001404	glycolate oxidase subunit GlcD; Provisional; Region: PRK11230
1423144001405	FAD binding domain; Region: FAD_binding_4; pfam01565
1423144001406	glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282
1423144001407	FAD binding domain; Region: FAD_binding_4; pfam01565
1423144001408	glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274
1423144001409	Cysteine-rich domain; Region: CCG; pfam02754
1423144001410	Cysteine-rich domain; Region: CCG; pfam02754
1423144001411	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
1423144001412	active site
1423144001413	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
1423144001414	active site
1423144001415	substrate binding sites [chemical binding]; other site
1423144001416	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1423144001417	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
1423144001418	putative dimer interface [polypeptide binding]; other site
1423144001419	Esterase-like activity of phytase; Region: Phytase-like; pfam13449
1423144001420	succinic semialdehyde dehydrogenase; Region: PLN02278
1423144001421	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1423144001422	tetramerization interface [polypeptide binding]; other site
1423144001423	NAD(P) binding site [chemical binding]; other site
1423144001424	catalytic residues [active]
1423144001425	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1423144001426	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1423144001427	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1423144001428	Creatine amidinohydrolase. E.C.3.5.3.3. Hydrolyzes creatine to sarcosine and urea; Region: Creatinase; cd01090
1423144001429	active site
1423144001430	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
1423144001431	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
1423144001432	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1423144001433	S-adenosylmethionine binding site [chemical binding]; other site
1423144001434	chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169
1423144001435	ATPase family associated with various cellular activities (AAA); Region: AAA; pfam00004
1423144001436	Walker A motif; other site
1423144001437	ATP binding site [chemical binding]; other site
1423144001438	Walker B motif; other site
1423144001439	arginine finger; other site
1423144001440	Protein of unknown function (DUF1523); Region: DUF1523; pfam07509
1423144001441	Core-2/I-Branching enzyme; Region: Branch; pfam02485
1423144001442	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
1423144001443	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1423144001444	nudix motif; other site
1423144001445	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
1423144001446	benzoate transporter; Region: benE; TIGR00843
1423144001447	Benzoate membrane transport protein; Region: BenE; pfam03594
1423144001448	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1423144001449	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1423144001450	non-specific DNA binding site [nucleotide binding]; other site
1423144001451	salt bridge; other site
1423144001452	sequence-specific DNA binding site [nucleotide binding]; other site
1423144001453	Cupin domain; Region: Cupin_2; pfam07883
1423144001454	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1423144001455	EamA-like transporter family; Region: EamA; pfam00892
1423144001456	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
1423144001457	SmpB-tmRNA interface; other site
1423144001458	3-mercaptopyruvate sulfurtransferase; Region: PLN02723
1423144001459	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
1423144001460	active site residue [active]
1423144001461	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
1423144001462	active site residue [active]
1423144001463	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
1423144001464	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1423144001465	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144001466	homodimer interface [polypeptide binding]; other site
1423144001467	catalytic residue [active]
1423144001468	probable ammonium transporter, marine subtype; Region: marine_trans_1; TIGR03644
1423144001469	Nitrogen regulatory protein P-II; Region: P-II; pfam00543
1423144001470	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1423144001471	Transglycosylase; Region: Transgly; pfam00912
1423144001472	penicillin-binding protein, 1A family; Region: PBP_1a_fam; TIGR02074
1423144001473	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
1423144001474	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1423144001475	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; pfam05494
1423144001476	VacJ like lipoprotein; Region: VacJ; cl01073
1423144001477	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
1423144001478	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1423144001479	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
1423144001480	Walker A/P-loop; other site
1423144001481	ATP binding site [chemical binding]; other site
1423144001482	Q-loop/lid; other site
1423144001483	ABC transporter signature motif; other site
1423144001484	Walker B; other site
1423144001485	D-loop; other site
1423144001486	H-loop/switch region; other site
1423144001487	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1423144001488	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1423144001489	HlyD family secretion protein; Region: HlyD_3; pfam13437
1423144001490	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
1423144001491	homotrimer interaction site [polypeptide binding]; other site
1423144001492	putative active site [active]
1423144001493	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
1423144001494	Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584
1423144001495	active site
1423144001496	catalytic site [active]
1423144001497	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; cl17497
1423144001498	Protein of unknown function, DUF482; Region: DUF482; pfam04339
1423144001499	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_b; cd00914
1423144001500	aromatic arch; other site
1423144001501	DCoH dimer interaction site [polypeptide binding]; other site
1423144001502	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
1423144001503	DCoH tetramer interaction site [polypeptide binding]; other site
1423144001504	substrate binding site [chemical binding]; other site
1423144001505	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
1423144001506	catalytic triad [active]
1423144001507	dimer interface [polypeptide binding]; other site
1423144001508	phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754
1423144001509	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1423144001510	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
1423144001511	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1423144001512	S-adenosylmethionine binding site [chemical binding]; other site
1423144001513	Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637
1423144001514	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1423144001515	motif II; other site
1423144001516	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
1423144001517	active site
1423144001518	Colicin V production protein; Region: Colicin_V; pfam02674
1423144001519	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1423144001520	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1423144001521	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
1423144001522	Predicted nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA [General function prediction only]; Region: CinA; COG1058
1423144001523	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
1423144001524	putative MPT binding site; other site
1423144001525	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1423144001526	PA26 p53-induced protein (sestrin); Region: PA26; pfam04636
1423144001527	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
1423144001528	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
1423144001529	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1423144001530	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1423144001531	ligand binding site [chemical binding]; other site
1423144001532	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1423144001533	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144001534	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1423144001535	putative effector binding pocket; other site
1423144001536	dimerization interface [polypeptide binding]; other site
1423144001537	Domain of unknown function (DUF4399); Region: DUF4399; pfam14347
1423144001538	NIPSNAP; Region: NIPSNAP; pfam07978
1423144001539	Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329
1423144001540	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1423144001541	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
1423144001542	active site
1423144001543	FMN binding site [chemical binding]; other site
1423144001544	2,4-decadienoyl-CoA binding site; other site
1423144001545	catalytic residue [active]
1423144001546	4Fe-4S cluster binding site [ion binding]; other site
1423144001547	Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446
1423144001548	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1423144001549	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
1423144001550	putative active site [active]
1423144001551	Ap4A binding site [chemical binding]; other site
1423144001552	nudix motif; other site
1423144001553	putative metal binding site [ion binding]; other site
1423144001554	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1423144001555	EamA-like transporter family; Region: EamA; pfam00892
1423144001556	EamA-like transporter family; Region: EamA; pfam00892
1423144001557	MarR family; Region: MarR_2; cl17246
1423144001558	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1423144001559	Adenosine kinase (AK) catalyzes the phosphorylation of ribofuranosyl-containing nucleoside analogues at the 5'-hydroxyl using ATP or GTP as the phosphate donor.The physiological function of AK is associated with the regulation of extracellular...; Region: adenosine_kinase; cd01168
1423144001560	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1423144001561	substrate binding site [chemical binding]; other site
1423144001562	ATP binding site [chemical binding]; other site
1423144001563	Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177
1423144001564	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1423144001565	minor groove reading motif; other site
1423144001566	helix-hairpin-helix signature motif; other site
1423144001567	substrate binding pocket [chemical binding]; other site
1423144001568	active site
1423144001569	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
1423144001570	Helix-turn-helix domain; Region: HTH_18; pfam12833
1423144001571	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1423144001572	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1423144001573	DNA binding site [nucleotide binding]
1423144001574	active site
1423144001575	Predicted transcriptional regulator [Transcription]; Region: COG2378
1423144001576	HTH domain; Region: HTH_11; pfam08279
1423144001577	WYL domain; Region: WYL; pfam13280
1423144001578	putative outer membrane lipoprotein; Provisional; Region: PRK10510
1423144001579	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1423144001580	ligand binding site [chemical binding]; other site
1423144001581	Predicted flavoprotein [General function prediction only]; Region: COG0431
1423144001582	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1423144001583	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
1423144001584	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1423144001585	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1423144001586	Uncharacterized conserved protein [Function unknown]; Region: COG4121
1423144001587	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1423144001588	EamA-like transporter family; Region: EamA; cl17759
1423144001589	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1423144001590	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1423144001591	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1423144001592	catalytic residue [active]
1423144001593	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1423144001594	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
1423144001595	dimer interface [polypeptide binding]; other site
1423144001596	active site
1423144001597	catalytic residue [active]
1423144001598	RNA polymerase sigma factor SigJ; Provisional; Region: PRK09636
1423144001599	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1423144001600	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1423144001601	Uncharacterized conserved protein [Function unknown]; Region: COG2128
1423144001602	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1423144001603	DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519
1423144001604	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
1423144001605	4Fe-4S binding domain; Region: Fer4; pfam00037
1423144001606	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
1423144001607	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1423144001608	molybdopterin cofactor binding site; other site
1423144001609	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1423144001610	The MopB_CT_2 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. This CD is...; Region: MopB_CT_2; cd02783
1423144001611	putative molybdopterin cofactor binding site; other site
1423144001612	Bacillus subtilis (Bs) citrate synthase (CS)-II_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). 2MCS catalyzes the...; Region: BSuCS-II_like; cd06110
1423144001613	dimer interface [polypeptide binding]; other site
1423144001614	Citrate synthase; Region: Citrate_synt; pfam00285
1423144001615	active site
1423144001616	citrylCoA binding site [chemical binding]; other site
1423144001617	oxalacetate/citrate binding site [chemical binding]; other site
1423144001618	coenzyme A binding site [chemical binding]; other site
1423144001619	catalytic triad [active]
1423144001620	Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212
1423144001621	Acetate kinase [Energy production and conversion]; Region: ackA; COG0282
1423144001622	propionate/acetate kinase; Provisional; Region: PRK12379
1423144001623	sulfoacetaldehyde acetyltransferase; Validated; Region: PRK07525
1423144001624	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1423144001625	PYR/PP interface [polypeptide binding]; other site
1423144001626	dimer interface [polypeptide binding]; other site
1423144001627	TPP binding site [chemical binding]; other site
1423144001628	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1423144001629	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1423144001630	TPP-binding site [chemical binding]; other site
1423144001631	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1423144001632	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1423144001633	DNA-binding site [nucleotide binding]; DNA binding site
1423144001634	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1423144001635	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144001636	homodimer interface [polypeptide binding]; other site
1423144001637	catalytic residue [active]
1423144001638	Penicillin-insensitive murein endopeptidase; Region: Peptidase_M74; cl01538
1423144001639	Predicted transcriptional regulators [Transcription]; Region: ArsR; COG0640
1423144001640	dimerization interface [polypeptide binding]; other site
1423144001641	putative DNA binding site [nucleotide binding]; other site
1423144001642	putative Zn2+ binding site [ion binding]; other site
1423144001643	Predicted permease; Region: DUF318; cl17795
1423144001644	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
1423144001645	classical (c) SDRs; Region: SDR_c; cd05233
1423144001646	NAD(P) binding site [chemical binding]; other site
1423144001647	active site
1423144001648	aminotransferase; Validated; Region: PRK07678
1423144001649	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1423144001650	inhibitor-cofactor binding pocket; inhibition site
1423144001651	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144001652	catalytic residue [active]
1423144001653	Prokaryotic protein of unknown function (DUF849); Region: DUF849; cl15827
1423144001654	hypothetical protein; Provisional; Region: PRK07483
1423144001655	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1423144001656	inhibitor-cofactor binding pocket; inhibition site
1423144001657	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144001658	catalytic residue [active]
1423144001659	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1423144001660	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1423144001661	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1423144001662	catalytic residue [active]
1423144001663	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
1423144001664	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
1423144001665	putative active site [active]
1423144001666	putative dimer interface [polypeptide binding]; other site
1423144001667	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
1423144001668	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896
1423144001669	Allophanate hydrolase subunit 2; Region: AHS2; pfam02626
1423144001670	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
1423144001671	putative active site [active]
1423144001672	reductive dehalogenase; Region: RDH; TIGR02486
1423144001673	reductive dehalogenase; Region: RDH; TIGR02486
1423144001674	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1423144001675	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
1423144001676	FMN-binding pocket [chemical binding]; other site
1423144001677	flavin binding motif; other site
1423144001678	phosphate binding motif [ion binding]; other site
1423144001679	beta-alpha-beta structure motif; other site
1423144001680	NAD binding pocket [chemical binding]; other site
1423144001681	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1423144001682	catalytic loop [active]
1423144001683	iron binding site [ion binding]; other site
1423144001684	Bacteriophytochrome (light-regulated signal transduction histidine kinase) [Signal transduction mechanisms]; Region: COG4251
1423144001685	GAF domain; Region: GAF; pfam01590
1423144001686	Phytochrome region; Region: PHY; pfam00360
1423144001687	HWE histidine kinase; Region: HWE_HK; pfam07536
1423144001688	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144001689	Response regulator receiver domain; Region: Response_reg; pfam00072
1423144001690	active site
1423144001691	phosphorylation site [posttranslational modification]
1423144001692	intermolecular recognition site; other site
1423144001693	dimerization interface [polypeptide binding]; other site
1423144001694	Putative zinc binding domain; Region: Methyltransf_13; pfam08421
1423144001695	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1423144001696	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1423144001697	S-adenosylmethionine binding site [chemical binding]; other site
1423144001698	C-methyltransferase C-terminal domain; Region: Methyltransf_14; pfam08484
1423144001699	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1423144001700	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1423144001701	NAD(P) binding site [chemical binding]; other site
1423144001702	active site
1423144001703	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1423144001704	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1423144001705	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1423144001706	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1423144001707	substrate binding pocket [chemical binding]; other site
1423144001708	membrane-bound complex binding site; other site
1423144001709	hinge residues; other site
1423144001710	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1423144001711	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1423144001712	substrate binding pocket [chemical binding]; other site
1423144001713	membrane-bound complex binding site; other site
1423144001714	hinge residues; other site
1423144001715	PAS domain; Region: PAS_9; pfam13426
1423144001716	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1423144001717	ATP binding site [chemical binding]; other site
1423144001718	Mg2+ binding site [ion binding]; other site
1423144001719	G-X-G motif; other site
1423144001720	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144001721	active site
1423144001722	phosphorylation site [posttranslational modification]
1423144001723	intermolecular recognition site; other site
1423144001724	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1423144001725	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144001726	active site
1423144001727	phosphorylation site [posttranslational modification]
1423144001728	intermolecular recognition site; other site
1423144001729	dimerization interface [polypeptide binding]; other site
1423144001730	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1423144001731	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1423144001732	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279
1423144001733	active site
1423144001734	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1423144001735	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
1423144001736	DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943
1423144001737	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1423144001738	non-specific DNA binding site [nucleotide binding]; other site
1423144001739	salt bridge; other site
1423144001740	sequence-specific DNA binding site [nucleotide binding]; other site
1423144001741	Cupin domain; Region: Cupin_2; pfam07883
1423144001742	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1423144001743	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144001744	dimer interface [polypeptide binding]; other site
1423144001745	conserved gate region; other site
1423144001746	putative PBP binding loops; other site
1423144001747	ABC-ATPase subunit interface; other site
1423144001748	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
1423144001749	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144001750	dimer interface [polypeptide binding]; other site
1423144001751	conserved gate region; other site
1423144001752	ABC-ATPase subunit interface; other site
1423144001753	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1423144001754	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1423144001755	Walker A/P-loop; other site
1423144001756	ATP binding site [chemical binding]; other site
1423144001757	Q-loop/lid; other site
1423144001758	ABC transporter signature motif; other site
1423144001759	Walker B; other site
1423144001760	D-loop; other site
1423144001761	H-loop/switch region; other site
1423144001762	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1423144001763	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1423144001764	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1423144001765	Walker A/P-loop; other site
1423144001766	ATP binding site [chemical binding]; other site
1423144001767	Q-loop/lid; other site
1423144001768	ABC transporter signature motif; other site
1423144001769	Walker B; other site
1423144001770	D-loop; other site
1423144001771	H-loop/switch region; other site
1423144001772	Hemerythrin-like domain; Region: Hr-like; cd12108
1423144001773	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1423144001774	Putative amidoligase enzyme; Region: Amidoligase_2; pfam12224
1423144001775	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
1423144001776	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
1423144001777	catalytic triad [active]
1423144001778	Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838
1423144001779	Monomeric isocitrate dehydrogenase; Region: IDH; cl15383
1423144001780	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1423144001781	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144001782	dimer interface [polypeptide binding]; other site
1423144001783	conserved gate region; other site
1423144001784	ABC-ATPase subunit interface; other site
1423144001785	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1423144001786	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1423144001787	Walker A/P-loop; other site
1423144001788	ATP binding site [chemical binding]; other site
1423144001789	Q-loop/lid; other site
1423144001790	ABC transporter signature motif; other site
1423144001791	Walker B; other site
1423144001792	D-loop; other site
1423144001793	H-loop/switch region; other site
1423144001794	ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715
1423144001795	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1423144001796	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1423144001797	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1423144001798	DNA-binding site [nucleotide binding]; DNA binding site
1423144001799	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1423144001800	DNA binding site [nucleotide binding]
1423144001801	active site
1423144001802	metal binding site [ion binding]; metal-binding site
1423144001803	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1423144001804	AAA domain; Region: AAA_23; pfam13476
1423144001805	Walker A/P-loop; other site
1423144001806	ATP binding site [chemical binding]; other site
1423144001807	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3807
1423144001808	Bacterial SH3 domain; Region: SH3_4; pfam06347
1423144001809	Bacterial SH3 domain; Region: SH3_4; pfam06347
1423144001810	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1423144001811	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
1423144001812	dimerization interface [polypeptide binding]; other site
1423144001813	ligand binding site [chemical binding]; other site
1423144001814	NADP binding site [chemical binding]; other site
1423144001815	catalytic site [active]
1423144001816	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1423144001817	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1423144001818	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1423144001819	FAD binding domain; Region: FAD_binding_4; pfam01565
1423144001820	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1423144001821	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1423144001822	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
1423144001823	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1423144001824	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
1423144001825	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640
1423144001826	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1423144001827	catalytic residue [active]
1423144001828	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1423144001829	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1423144001830	putative DNA binding site [nucleotide binding]; other site
1423144001831	putative Zn2+ binding site [ion binding]; other site
1423144001832	AsnC family; Region: AsnC_trans_reg; pfam01037
1423144001833	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1423144001834	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1423144001835	S-adenosylmethionine binding site [chemical binding]; other site
1423144001836	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1423144001837	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1423144001838	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1423144001839	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1423144001840	active site
1423144001841	catalytic tetrad [active]
1423144001842	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
1423144001843	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
1423144001844	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
1423144001845	putative ligand binding site [chemical binding]; other site
1423144001846	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1423144001847	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1423144001848	TM-ABC transporter signature motif; other site
1423144001849	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1423144001850	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1423144001851	TM-ABC transporter signature motif; other site
1423144001852	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
1423144001853	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1423144001854	Walker A/P-loop; other site
1423144001855	ATP binding site [chemical binding]; other site
1423144001856	Q-loop/lid; other site
1423144001857	ABC transporter signature motif; other site
1423144001858	Walker B; other site
1423144001859	D-loop; other site
1423144001860	H-loop/switch region; other site
1423144001861	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1423144001862	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
1423144001863	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
1423144001864	XdhC Rossmann domain; Region: XdhC_C; pfam13478
1423144001865	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
1423144001866	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1423144001867	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1423144001868	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
1423144001869	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1423144001870	catalytic loop [active]
1423144001871	iron binding site [ion binding]; other site
1423144001872	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1423144001873	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
1423144001874	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
1423144001875	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
1423144001876	putative active site [active]
1423144001877	putative PHP Thumb interface [polypeptide binding]; other site
1423144001878	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
1423144001879	generic binding surface II; other site
1423144001880	generic binding surface I; other site
1423144001881	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
1423144001882	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1423144001883	Coenzyme A binding pocket [chemical binding]; other site
1423144001884	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1423144001885	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1423144001886	putative DNA binding site [nucleotide binding]; other site
1423144001887	putative Zn2+ binding site [ion binding]; other site
1423144001888	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1423144001889	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
1423144001890	Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536
1423144001891	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1423144001892	ligand binding site [chemical binding]; other site
1423144001893	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1423144001894	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1423144001895	TM-ABC transporter signature motif; other site
1423144001896	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1423144001897	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1423144001898	Walker A/P-loop; other site
1423144001899	ATP binding site [chemical binding]; other site
1423144001900	Q-loop/lid; other site
1423144001901	ABC transporter signature motif; other site
1423144001902	Walker B; other site
1423144001903	D-loop; other site
1423144001904	H-loop/switch region; other site
1423144001905	nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270
1423144001906	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1423144001907	active site
1423144001908	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1423144001909	Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167
1423144001910	putative substrate binding site [chemical binding]; other site
1423144001911	putative ATP binding site [chemical binding]; other site
1423144001912	Uncharacterized conserved protein [Function unknown]; Region: COG3791
1423144001913	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
1423144001914	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1423144001915	active site
1423144001916	intersubunit interface [polypeptide binding]; other site
1423144001917	catalytic residue [active]
1423144001918	phosphogluconate dehydratase; Validated; Region: PRK09054
1423144001919	6-phosphogluconate dehydratase; Region: edd; TIGR01196
1423144001920	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1423144001921	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1423144001922	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1423144001923	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
1423144001924	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
1423144001925	active site
1423144001926	dimer interface [polypeptide binding]; other site
1423144001927	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
1423144001928	dimer interface [polypeptide binding]; other site
1423144001929	active site
1423144001930	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1423144001931	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1423144001932	Walker A/P-loop; other site
1423144001933	ATP binding site [chemical binding]; other site
1423144001934	Q-loop/lid; other site
1423144001935	ABC transporter signature motif; other site
1423144001936	Walker B; other site
1423144001937	D-loop; other site
1423144001938	H-loop/switch region; other site
1423144001939	TOBE domain; Region: TOBE_2; pfam08402
1423144001940	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1423144001941	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1423144001942	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1423144001943	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144001944	dimer interface [polypeptide binding]; other site
1423144001945	conserved gate region; other site
1423144001946	putative PBP binding loops; other site
1423144001947	ABC-ATPase subunit interface; other site
1423144001948	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1423144001949	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144001950	dimer interface [polypeptide binding]; other site
1423144001951	conserved gate region; other site
1423144001952	putative PBP binding loops; other site
1423144001953	ABC-ATPase subunit interface; other site
1423144001954	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1423144001955	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1423144001956	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
1423144001957	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
1423144001958	putative active site [active]
1423144001959	Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971
1423144001960	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1423144001961	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1423144001962	DNA-binding site [nucleotide binding]; DNA binding site
1423144001963	UTRA domain; Region: UTRA; pfam07702
1423144001964	Predicted phosphosugar isomerases [Cell envelope biogenesis, outer membrane]; Region: AgaS; COG2222
1423144001965	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1423144001966	dimer interface [polypeptide binding]; other site
1423144001967	active site
1423144001968	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1423144001969	dimer interface [polypeptide binding]; other site
1423144001970	active site
1423144001971	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1423144001972	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
1423144001973	active site
1423144001974	Protein of unknown function (DUF971); Region: DUF971; cl01414
1423144001975	gamma-butyrobetaine hydroxylase; Region: carnitine_bodg; TIGR02409
1423144001976	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250
1423144001977	substrate binding pocket [chemical binding]; other site
1423144001978	active site
1423144001979	iron coordination sites [ion binding]; other site
1423144001980	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1423144001981	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1423144001982	X-Pro dipeptidyl-peptidase (S15 family); Region: Peptidase_S15; pfam02129
1423144001983	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
1423144001984	X-Pro dipeptidyl-peptidase C-terminal non-catalytic domain; Region: PepX_C; smart00939
1423144001985	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
1423144001986	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
1423144001987	Ligand binding site; other site
1423144001988	Putative Catalytic site; other site
1423144001989	DXD motif; other site
1423144001990	GtrA-like protein; Region: GtrA; pfam04138
1423144001991	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1423144001992	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1423144001993	Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157
1423144001994	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
1423144001995	dimerization interface [polypeptide binding]; other site
1423144001996	active site
1423144001997	L-aspartate oxidase; Provisional; Region: PRK07512
1423144001998	L-aspartate oxidase; Provisional; Region: PRK06175
1423144001999	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1423144002000	quinolinate synthetase; Provisional; Region: PRK09375
1423144002001	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1423144002002	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1423144002003	phosphate transporter ATP-binding protein; Provisional; Region: PRK14242
1423144002004	Walker A/P-loop; other site
1423144002005	ATP binding site [chemical binding]; other site
1423144002006	Q-loop/lid; other site
1423144002007	ABC transporter signature motif; other site
1423144002008	Walker B; other site
1423144002009	D-loop; other site
1423144002010	H-loop/switch region; other site
1423144002011	PBP superfamily domain; Region: PBP_like_2; pfam12849
1423144002012	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
1423144002013	antiporter inner membrane protein; Provisional; Region: PRK11670
1423144002014	Domain of unknown function DUF59; Region: DUF59; pfam01883
1423144002015	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1423144002016	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1423144002017	4Fe-4S binding domain; Region: Fer4; pfam00037
1423144002018	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1423144002019	4Fe-4S binding domain; Region: Fer4; pfam00037
1423144002020	Protein of unknown function (DUF3305); Region: DUF3305; pfam11749
1423144002021	Protein of unknown function (DUF3306); Region: DUF3306; pfam11748
1423144002022	Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613
1423144002023	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
1423144002024	[4Fe-4S] binding site [ion binding]; other site
1423144002025	molybdopterin cofactor binding site; other site
1423144002026	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1423144002027	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
1423144002028	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
1423144002029	molybdopterin cofactor binding site; other site
1423144002030	DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951
1423144002031	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
1423144002032	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
1423144002033	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1423144002034	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
1423144002035	structural tetrad; other site
1423144002036	Cytochrome c; Region: Cytochrom_C; cl11414
1423144002037	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1423144002038	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144002039	active site
1423144002040	phosphorylation site [posttranslational modification]
1423144002041	intermolecular recognition site; other site
1423144002042	dimerization interface [polypeptide binding]; other site
1423144002043	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1423144002044	Walker A motif; other site
1423144002045	ATP binding site [chemical binding]; other site
1423144002046	Walker B motif; other site
1423144002047	arginine finger; other site
1423144002048	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1423144002049	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1423144002050	dimerization interface [polypeptide binding]; other site
1423144002051	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1423144002052	dimer interface [polypeptide binding]; other site
1423144002053	phosphorylation site [posttranslational modification]
1423144002054	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1423144002055	ATP binding site [chemical binding]; other site
1423144002056	Mg2+ binding site [ion binding]; other site
1423144002057	G-X-G motif; other site
1423144002058	C factor cell-cell signaling protein; Provisional; Region: PRK09009
1423144002059	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
1423144002060	NADP binding site [chemical binding]; other site
1423144002061	homodimer interface [polypeptide binding]; other site
1423144002062	active site
1423144002063	Short-chain dehydrogenases of various substrate specificities [General function prediction only]; Region: DltE; COG0300
1423144002064	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1423144002065	NAD(P) binding site [chemical binding]; other site
1423144002066	active site
1423144002067	Protein of unknown function (DUF3833); Region: DUF3833; pfam12915
1423144002068	MFS/sugar transport protein; Region: MFS_2; pfam13347
1423144002069	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
1423144002070	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1423144002071	S-adenosylmethionine binding site [chemical binding]; other site
1423144002072	Protein of unknown function (DUF1365); Region: DUF1365; pfam07103
1423144002073	Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907
1423144002074	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1423144002075	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1423144002076	RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652
1423144002077	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1423144002078	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1423144002079	DNA binding residues [nucleotide binding]
1423144002080	anti-sigma factor, putative, ChrR family; Region: anti_sig_ChrR; TIGR02451
1423144002081	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
1423144002082	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
1423144002083	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1423144002084	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1423144002085	Nitrate and nitrite sensing; Region: NIT; pfam08376
1423144002086	HAMP domain; Region: HAMP; pfam00672
1423144002087	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1423144002088	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1423144002089	dimer interface [polypeptide binding]; other site
1423144002090	putative CheW interface [polypeptide binding]; other site
1423144002091	Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480
1423144002092	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
1423144002093	TAP-like protein; Region: Abhydrolase_4; pfam08386
1423144002094	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
1423144002095	substrate binding site [chemical binding]; other site
1423144002096	THF binding site; other site
1423144002097	zinc-binding site [ion binding]; other site
1423144002098	Cupin domain; Region: Cupin_2; pfam07883
1423144002099	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
1423144002100	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1423144002101	SnoaL-like domain; Region: SnoaL_2; pfam12680
1423144002102	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1423144002103	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1423144002104	DNA binding site [nucleotide binding]
1423144002105	domain linker motif; other site
1423144002106	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278
1423144002107	putative dimerization interface [polypeptide binding]; other site
1423144002108	putative ligand binding site [chemical binding]; other site
1423144002109	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1423144002110	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1423144002111	NAD(P) binding site [chemical binding]; other site
1423144002112	active site
1423144002113	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1423144002114	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1423144002115	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1423144002116	histidinol dehydrogenase; Region: hisD; TIGR00069
1423144002117	NAD binding site [chemical binding]; other site
1423144002118	dimerization interface [polypeptide binding]; other site
1423144002119	product binding site; other site
1423144002120	substrate binding site [chemical binding]; other site
1423144002121	zinc binding site [ion binding]; other site
1423144002122	catalytic residues [active]
1423144002123	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1423144002124	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1423144002125	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144002126	dimer interface [polypeptide binding]; other site
1423144002127	conserved gate region; other site
1423144002128	putative PBP binding loops; other site
1423144002129	ABC-ATPase subunit interface; other site
1423144002130	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144002131	dimer interface [polypeptide binding]; other site
1423144002132	conserved gate region; other site
1423144002133	ABC-ATPase subunit interface; other site
1423144002134	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1423144002135	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1423144002136	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1423144002137	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1423144002138	Walker A/P-loop; other site
1423144002139	ATP binding site [chemical binding]; other site
1423144002140	Q-loop/lid; other site
1423144002141	ABC transporter signature motif; other site
1423144002142	Walker B; other site
1423144002143	D-loop; other site
1423144002144	H-loop/switch region; other site
1423144002145	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1423144002146	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1423144002147	Amidohydrolase; Region: Amidohydro_2; pfam04909
1423144002148	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
1423144002149	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144002150	Response regulator receiver domain; Region: Response_reg; pfam00072
1423144002151	active site
1423144002152	phosphorylation site [posttranslational modification]
1423144002153	intermolecular recognition site; other site
1423144002154	dimerization interface [polypeptide binding]; other site
1423144002155	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1423144002156	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1423144002157	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1423144002158	ATP binding site [chemical binding]; other site
1423144002159	Mg2+ binding site [ion binding]; other site
1423144002160	G-X-G motif; other site
1423144002161	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1423144002162	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144002163	active site
1423144002164	phosphorylation site [posttranslational modification]
1423144002165	intermolecular recognition site; other site
1423144002166	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
1423144002167	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144002168	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1423144002169	dimerization interface [polypeptide binding]; other site
1423144002170	gamma-butyrobetaine hydroxylase; Region: carnitine_bodg; TIGR02409
1423144002171	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250
1423144002172	substrate binding pocket [chemical binding]; other site
1423144002173	active site
1423144002174	iron coordination sites [ion binding]; other site
1423144002175	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1423144002176	Zn2+ binding site [ion binding]; other site
1423144002177	Mg2+ binding site [ion binding]; other site
1423144002178	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1423144002179	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
1423144002180	putative active site [active]
1423144002181	metal binding site [ion binding]; metal-binding site
1423144002182	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1423144002183	Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102
1423144002184	NAD(P) binding site [chemical binding]; other site
1423144002185	catalytic residues [active]
1423144002186	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1423144002187	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1423144002188	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
1423144002189	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
1423144002190	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
1423144002191	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
1423144002192	N-formylglutamate amidohydrolase; Region: FGase; cl01522
1423144002193	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1423144002194	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1423144002195	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1423144002196	putative active site [active]
1423144002197	Ferritin-like domain; Region: Ferritin; pfam00210
1423144002198	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1423144002199	dimerization interface [polypeptide binding]; other site
1423144002200	DPS ferroxidase diiron center [ion binding]; other site
1423144002201	ion pore; other site
1423144002202	two-component response regulator; Provisional; Region: PRK09191
1423144002203	Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281
1423144002204	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144002205	active site
1423144002206	phosphorylation site [posttranslational modification]
1423144002207	intermolecular recognition site; other site
1423144002208	dimerization interface [polypeptide binding]; other site
1423144002209	RNA polymerase sigma factor; Provisional; Region: PRK12546
1423144002210	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1423144002211	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1423144002212	DNA binding residues [nucleotide binding]
1423144002213	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1423144002214	Histidine kinase; Region: HisKA_2; pfam07568
1423144002215	Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; Region: HATPase_c; pfam02518
1423144002216	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1423144002217	putative active site [active]
1423144002218	catalytic site [active]
1423144002219	Catalytic domain, repeat 2, of vertebrate phospholipases, PLD1 and PLD2, and similar proteins; Region: PLDc_vPLD1_2_like_2; cd09105
1423144002220	PLD-like domain; Region: PLDc_2; pfam13091
1423144002221	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1423144002222	putative active site [active]
1423144002223	putative active site [active]
1423144002224	catalytic site [active]
1423144002225	catalytic site [active]
1423144002226	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1423144002227	Protein of unknown function (DUF1469); Region: DUF1469; pfam07332
1423144002228	CsbD-like; Region: CsbD; cl17424
1423144002229	Uncharacterized stress protein (general stress protein 26) [General function prediction only]; Region: COG3871
1423144002230	Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381
1423144002231	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
1423144002232	Rho termination factor, N-terminal domain; Region: Rho_N; cl06505
1423144002233	BON domain; Region: BON; pfam04972
1423144002234	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1423144002235	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1423144002236	Entericidin EcnA/B family; Region: Entericidin; cl02322
1423144002237	Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055
1423144002238	cytosine deaminase; Validated; Region: PRK07572
1423144002239	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
1423144002240	active site
1423144002241	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1423144002242	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1423144002243	TM-ABC transporter signature motif; other site
1423144002244	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1423144002245	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1423144002246	TM-ABC transporter signature motif; other site
1423144002247	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
1423144002248	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1423144002249	Walker A/P-loop; other site
1423144002250	ATP binding site [chemical binding]; other site
1423144002251	Q-loop/lid; other site
1423144002252	ABC transporter signature motif; other site
1423144002253	Walker B; other site
1423144002254	D-loop; other site
1423144002255	H-loop/switch region; other site
1423144002256	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1423144002257	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
1423144002258	Periplasmic binding domain of the basic membrane lipoprotein Med in Bacillus and its close homologs from other bacteria and Archaea; Region: PBP1_BmpA_Med_like; cd06353
1423144002259	putative ligand binding site [chemical binding]; other site
1423144002260	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
1423144002261	homotrimer interaction site [polypeptide binding]; other site
1423144002262	putative active site [active]
1423144002263	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1423144002264	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1423144002265	dimer interface [polypeptide binding]; other site
1423144002266	putative PBP binding regions; other site
1423144002267	ABC-ATPase subunit  interface; other site
1423144002268	proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868
1423144002269	Metal binding protein TroA_a.  These proteins are predicted to function as initial receptors in ABC transport of metal ions in eubacteria. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and...; Region: TroA_a; cd01148
1423144002270	putative ligand binding residues [chemical binding]; other site
1423144002271	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1423144002272	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1423144002273	Walker A/P-loop; other site
1423144002274	ATP binding site [chemical binding]; other site
1423144002275	Q-loop/lid; other site
1423144002276	ABC transporter signature motif; other site
1423144002277	Walker B; other site
1423144002278	D-loop; other site
1423144002279	H-loop/switch region; other site
1423144002280	Protein of unknown function (DUF1636); Region: DUF1636; pfam07845
1423144002281	PaaX-like protein; Region: PaaX; pfam07848
1423144002282	PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223
1423144002283	bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563
1423144002284	N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128
1423144002285	substrate binding site [chemical binding]; other site
1423144002286	dimer interface [polypeptide binding]; other site
1423144002287	NADP binding site [chemical binding]; other site
1423144002288	catalytic residues [active]
1423144002289	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1423144002290	active site 2 [active]
1423144002291	active site 1 [active]
1423144002292	enoyl-CoA hydratase; Provisional; Region: PRK08140
1423144002293	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1423144002294	substrate binding site [chemical binding]; other site
1423144002295	oxyanion hole (OAH) forming residues; other site
1423144002296	trimer interface [polypeptide binding]; other site
1423144002297	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1423144002298	CoenzymeA binding site [chemical binding]; other site
1423144002299	subunit interaction site [polypeptide binding]; other site
1423144002300	PHB binding site; other site
1423144002301	Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913
1423144002302	phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155
1423144002303	active site
1423144002304	AMP binding site [chemical binding]; other site
1423144002305	homodimer interface [polypeptide binding]; other site
1423144002306	acyl-activating enzyme (AAE) consensus motif; other site
1423144002307	CoA binding site [chemical binding]; other site
1423144002308	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1423144002309	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1423144002310	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1423144002311	DNA-binding site [nucleotide binding]; DNA binding site
1423144002312	RNA-binding motif; other site
1423144002313	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
1423144002314	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
1423144002315	active site
1423144002316	HIGH motif; other site
1423144002317	dimer interface [polypeptide binding]; other site
1423144002318	KMSKS motif; other site
1423144002319	Rhomboid family; Region: Rhomboid; cl11446
1423144002320	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
1423144002321	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
1423144002322	PII uridylyl-transferase; Provisional; Region: PRK05092
1423144002323	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1423144002324	metal binding triad; other site
1423144002325	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1423144002326	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1423144002327	Zn2+ binding site [ion binding]; other site
1423144002328	Mg2+ binding site [ion binding]; other site
1423144002329	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
1423144002330	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
1423144002331	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1423144002332	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
1423144002333	putative ligand binding site [chemical binding]; other site
1423144002334	Predicted methyltransferases [General function prediction only]; Region: COG0313
1423144002335	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
1423144002336	putative SAM binding site [chemical binding]; other site
1423144002337	putative homodimer interface [polypeptide binding]; other site
1423144002338	Uncharacterized protein family UPF0102; Region: UPF0102; cl00516
1423144002339	glutathione synthetase; Provisional; Region: PRK05246
1423144002340	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
1423144002341	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
1423144002342	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
1423144002343	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1423144002344	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1423144002345	Walker A motif; other site
1423144002346	ATP binding site [chemical binding]; other site
1423144002347	Walker B motif; other site
1423144002348	arginine finger; other site
1423144002349	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
1423144002350	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1423144002351	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1423144002352	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
1423144002353	putative N-terminal domain interface [polypeptide binding]; other site
1423144002354	putative dimer interface [polypeptide binding]; other site
1423144002355	putative substrate binding pocket (H-site) [chemical binding]; other site
1423144002356	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1423144002357	catalytic core [active]
1423144002358	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
1423144002359	homotrimer interface [polypeptide binding]; other site
1423144002360	Walker A motif; other site
1423144002361	GTP binding site [chemical binding]; other site
1423144002362	Walker B motif; other site
1423144002363	RNA polymerase factor sigma-32; Reviewed; Region: rpoH2; PRK07500
1423144002364	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1423144002365	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1423144002366	DNA binding residues [nucleotide binding]
1423144002367	Protein of unknown function, DUF399; Region: DUF399; pfam04187
1423144002368	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
1423144002369	Flavoprotein; Region: Flavoprotein; pfam02441
1423144002370	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
1423144002371	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557
1423144002372	trimer interface [polypeptide binding]; other site
1423144002373	active site
1423144002374	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
1423144002375	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1423144002376	ATP binding site [chemical binding]; other site
1423144002377	substrate interface [chemical binding]; other site
1423144002378	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1423144002379	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1423144002380	substrate binding pocket [chemical binding]; other site
1423144002381	membrane-bound complex binding site; other site
1423144002382	hinge residues; other site
1423144002383	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144002384	dimer interface [polypeptide binding]; other site
1423144002385	conserved gate region; other site
1423144002386	putative PBP binding loops; other site
1423144002387	ABC-ATPase subunit interface; other site
1423144002388	Zn-dependent oligopeptidases [Amino acid transport and metabolism]; Region: Dcp; COG0339
1423144002389	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
1423144002390	active site
1423144002391	Zn binding site [ion binding]; other site
1423144002392	Tryptophan halogenase; Region: Trp_halogenase; pfam04820
1423144002393	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
1423144002394	Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164
1423144002395	putative ligand binding site [chemical binding]; other site
1423144002396	NAD binding site [chemical binding]; other site
1423144002397	dimerization interface [polypeptide binding]; other site
1423144002398	catalytic site [active]
1423144002399	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1423144002400	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_18; cd08357
1423144002401	putative metal binding site [ion binding]; other site
1423144002402	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1423144002403	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144002404	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1423144002405	dimerization interface [polypeptide binding]; other site
1423144002406	rod shape-determining protein RodA; Region: rodA_shape; TIGR02210
1423144002407	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
1423144002408	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1423144002409	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1423144002410	rod shape-determining protein MreC; Provisional; Region: PRK13922
1423144002411	rod shape-determining protein MreC; Region: MreC; pfam04085
1423144002412	rod shape-determining protein MreB; Provisional; Region: PRK13927
1423144002413	MreB and similar proteins; Region: MreB_like; cd10225
1423144002414	nucleotide binding site [chemical binding]; other site
1423144002415	Mg binding site [ion binding]; other site
1423144002416	putative protofilament interaction site [polypeptide binding]; other site
1423144002417	RodZ interaction site [polypeptide binding]; other site
1423144002418	Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961
1423144002419	2-isopropylmalate synthase; Validated; Region: PRK00915
1423144002420	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
1423144002421	active site
1423144002422	catalytic residues [active]
1423144002423	metal binding site [ion binding]; metal-binding site
1423144002424	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1423144002425	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
1423144002426	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
1423144002427	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4642
1423144002428	NAD synthetase; Provisional; Region: PRK13981
1423144002429	Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570
1423144002430	multimer interface [polypeptide binding]; other site
1423144002431	active site
1423144002432	catalytic triad [active]
1423144002433	protein interface 1 [polypeptide binding]; other site
1423144002434	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
1423144002435	homodimer interface [polypeptide binding]; other site
1423144002436	NAD binding pocket [chemical binding]; other site
1423144002437	ATP binding pocket [chemical binding]; other site
1423144002438	Mg binding site [ion binding]; other site
1423144002439	active-site loop [active]
1423144002440	PAS fold; Region: PAS_7; pfam12860
1423144002441	GAF domain; Region: GAF_3; pfam13492
1423144002442	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1423144002443	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1423144002444	metal binding site [ion binding]; metal-binding site
1423144002445	active site
1423144002446	I-site; other site
1423144002447	glutamyl-tRNA synthetase; Provisional; Region: PRK12558
1423144002448	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1423144002449	HIGH motif; other site
1423144002450	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1423144002451	active site
1423144002452	KMSKS motif; other site
1423144002453	Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011
1423144002454	Predicted membrane protein [Function unknown]; Region: COG4325
1423144002455	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1423144002456	putative active site pocket [active]
1423144002457	dimerization interface [polypeptide binding]; other site
1423144002458	putative catalytic residue [active]
1423144002459	Predicted transcriptional regulator [Transcription]; Region: COG1959
1423144002460	Transcriptional regulator; Region: Rrf2; cl17282
1423144002461	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
1423144002462	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1423144002463	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG4181
1423144002464	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1423144002465	Walker A/P-loop; other site
1423144002466	ATP binding site [chemical binding]; other site
1423144002467	Q-loop/lid; other site
1423144002468	ABC transporter signature motif; other site
1423144002469	Walker B; other site
1423144002470	D-loop; other site
1423144002471	H-loop/switch region; other site
1423144002472	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
1423144002473	active site
1423144002474	catalytic triad [active]
1423144002475	oxyanion hole [active]
1423144002476	switch loop; other site
1423144002477	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1423144002478	DNA-binding site [nucleotide binding]; DNA binding site
1423144002479	RNA-binding motif; other site
1423144002480	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1423144002481	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1423144002482	Protein of unknown function (DUF3573); Region: DUF3573; pfam12097
1423144002483	thioredoxin 2; Provisional; Region: PRK10996
1423144002484	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1423144002485	catalytic residues [active]
1423144002486	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
1423144002487	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1423144002488	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1423144002489	ABC transporter; Region: ABC_tran_2; pfam12848
1423144002490	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1423144002491	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
1423144002492	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
1423144002493	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
1423144002494	Cytidylyltransferase; Region: CTP_transf_2; pfam01467
1423144002495	active site
1423144002496	(T/H)XGH motif; other site
1423144002497	D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429
1423144002498	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1423144002499	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1423144002500	tellurite resistance protein terB; Region: terB; cd07176
1423144002501	putative metal binding site [ion binding]; other site
1423144002502	lysyl-tRNA synthetase; Reviewed; Region: lysK; PRK00750
1423144002503	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1423144002504	active site
1423144002505	nucleotide binding site [chemical binding]; other site
1423144002506	HIGH motif; other site
1423144002507	KMSKS motif; other site
1423144002508	Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708
1423144002509	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
1423144002510	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1423144002511	Ligand Binding Site [chemical binding]; other site
1423144002512	Transcription factor zinc-finger; Region: zf-TFIIB; cl01565
1423144002513	excinuclease ABC subunit B; Provisional; Region: PRK05298
1423144002514	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1423144002515	ATP binding site [chemical binding]; other site
1423144002516	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1423144002517	nucleotide binding region [chemical binding]; other site
1423144002518	ATP-binding site [chemical binding]; other site
1423144002519	Ultra-violet resistance protein B; Region: UvrB; pfam12344
1423144002520	UvrB/uvrC motif; Region: UVR; pfam02151
1423144002521	ETC complex I subunit conserved region; Region: ETC_C1_NDUFA4; pfam04800
1423144002522	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
1423144002523	active site
1423144002524	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
1423144002525	Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151
1423144002526	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
1423144002527	PLD-like domain; Region: PLDc_2; pfam13091
1423144002528	putative active site [active]
1423144002529	catalytic site [active]
1423144002530	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
1423144002531	PLD-like domain; Region: PLDc_2; pfam13091
1423144002532	putative active site [active]
1423144002533	catalytic site [active]
1423144002534	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
1423144002535	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
1423144002536	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
1423144002537	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1423144002538	Uncharacterized protein family (UPF0160); Region: UPF0160; pfam03690
1423144002539	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
1423144002540	Domain of unknown function (DUF1772); Region: DUF1772; cl12097
1423144002541	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
1423144002542	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1423144002543	MarR family; Region: MarR_2; pfam12802
1423144002544	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1423144002545	MarR family; Region: MarR_2; pfam12802
1423144002546	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1423144002547	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cd00322
1423144002548	FAD binding pocket [chemical binding]; other site
1423144002549	conserved FAD binding motif [chemical binding]; other site
1423144002550	phosphate binding motif [ion binding]; other site
1423144002551	beta-alpha-beta structure motif; other site
1423144002552	NAD binding pocket [chemical binding]; other site
1423144002553	ferrichrome outer membrane transporter; Provisional; Region: PRK10044
1423144002554	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1423144002555	N-terminal plug; other site
1423144002556	ligand-binding site [chemical binding]; other site
1423144002557	Gram-negative bacterial tonB protein; Region: TonB; cl10048
1423144002558	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
1423144002559	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
1423144002560	Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811
1423144002561	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
1423144002562	FAD binding pocket [chemical binding]; other site
1423144002563	FAD binding motif [chemical binding]; other site
1423144002564	phosphate binding motif [ion binding]; other site
1423144002565	NAD binding pocket [chemical binding]; other site
1423144002566	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1423144002567	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1423144002568	Walker A/P-loop; other site
1423144002569	ATP binding site [chemical binding]; other site
1423144002570	Q-loop/lid; other site
1423144002571	ABC transporter signature motif; other site
1423144002572	Walker B; other site
1423144002573	D-loop; other site
1423144002574	H-loop/switch region; other site
1423144002575	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
1423144002576	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1423144002577	ABC-ATPase subunit  interface; other site
1423144002578	dimer interface [polypeptide binding]; other site
1423144002579	putative PBP binding regions; other site
1423144002580	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1423144002581	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1423144002582	ABC-ATPase subunit  interface; other site
1423144002583	dimer interface [polypeptide binding]; other site
1423144002584	putative PBP binding regions; other site
1423144002585	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1423144002586	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1423144002587	intersubunit interface [polypeptide binding]; other site
1423144002588	SnoaL-like domain; Region: SnoaL_2; pfam12680
1423144002589	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1423144002590	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1423144002591	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1423144002592	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
1423144002593	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1423144002594	Walker A motif; other site
1423144002595	ATP binding site [chemical binding]; other site
1423144002596	Walker B motif; other site
1423144002597	arginine finger; other site
1423144002598	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1423144002599	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1423144002600	Coenzyme A binding pocket [chemical binding]; other site
1423144002601	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1423144002602	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1423144002603	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4619
1423144002604	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1423144002605	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1423144002606	S-adenosylmethionine binding site [chemical binding]; other site
1423144002607	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1423144002608	dimerization interface [polypeptide binding]; other site
1423144002609	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1423144002610	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1423144002611	dimer interface [polypeptide binding]; other site
1423144002612	putative CheW interface [polypeptide binding]; other site
1423144002613	MarR family; Region: MarR_2; cl17246
1423144002614	DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242
1423144002615	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144002616	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1423144002617	NADH dehydrogenase subunit E; Validated; Region: PRK07539
1423144002618	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E family, Tungsten-containing formate dehydrogenase (W-FDH) beta subunit; composed of proteins similar to the W-FDH beta subunit of Methylobacterium extorquens. W-FDH...; Region: TRX_Fd_NuoE_W_FDH_beta; cd03082
1423144002619	putative dimer interface [polypeptide binding]; other site
1423144002620	[2Fe-2S] cluster binding site [ion binding]; other site
1423144002621	NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894
1423144002622	SLBB domain; Region: SLBB; pfam10531
1423144002623	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
1423144002624	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1423144002625	Uncharacterized anaerobic dehydrogenase [General function prediction only]; Region: COG3383
1423144002626	catalytic loop [active]
1423144002627	iron binding site [ion binding]; other site
1423144002628	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; smart00929
1423144002629	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
1423144002630	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
1423144002631	[4Fe-4S] binding site [ion binding]; other site
1423144002632	molybdopterin cofactor binding site; other site
1423144002633	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
1423144002634	molybdopterin cofactor binding site; other site
1423144002635	mycofactocin system FadH/OYE family oxidoreductase 2; Region: mycofact_OYE_2; TIGR03997
1423144002636	Old yellow enzyme (OYE)-related FMN binding domain, group 3. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_3_FMN; cd04734
1423144002637	putative active site [active]
1423144002638	putative FMN binding site [chemical binding]; other site
1423144002639	putative substrate binding site [chemical binding]; other site
1423144002640	putative catalytic residue [active]
1423144002641	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1423144002642	Hint domain; Region: Hint_2; pfam13403
1423144002643	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
1423144002644	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
1423144002645	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1423144002646	RNA binding surface [nucleotide binding]; other site
1423144002647	PA14 domain; Region: PA14; cl08459
1423144002648	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1423144002649	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
1423144002650	AsnC family; Region: AsnC_trans_reg; pfam01037
1423144002651	histidinol-phosphate aminotransferase; Validated; Region: PRK02731
1423144002652	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1423144002653	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144002654	homodimer interface [polypeptide binding]; other site
1423144002655	catalytic residue [active]
1423144002656	cyclohexadienyl dehydrogenase; Validated; Region: PRK07502
1423144002657	prephenate dehydrogenase; Validated; Region: PRK08507
1423144002658	Extensin-like protein C-terminus; Region: Extensin-like_C; pfam06904
1423144002659	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4093
1423144002660	Uncharacterized protein conserved in bacteria (DUF2125); Region: DUF2125; pfam09898
1423144002661	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1423144002662	putative active site pocket [active]
1423144002663	dimerization interface [polypeptide binding]; other site
1423144002664	putative catalytic residue [active]
1423144002665	hypothetical protein; Validated; Region: PRK09039
1423144002666	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1423144002667	ligand binding site [chemical binding]; other site
1423144002668	Uncharacterized protein conserved in bacteria (DUF2087); Region: DUF2087; pfam09860
1423144002669	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1423144002670	Peptidase family M23; Region: Peptidase_M23; pfam01551
1423144002671	ATP-dependent Clp protease ATP-binding subunit clpA; Region: ClpA; TIGR02639
1423144002672	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1423144002673	Walker A motif; other site
1423144002674	ATP binding site [chemical binding]; other site
1423144002675	Walker B motif; other site
1423144002676	arginine finger; other site
1423144002677	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1423144002678	Walker A motif; other site
1423144002679	ATP binding site [chemical binding]; other site
1423144002680	Walker B motif; other site
1423144002681	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1423144002682	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
1423144002683	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1423144002684	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1423144002685	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
1423144002686	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
1423144002687	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
1423144002688	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1423144002689	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
1423144002690	beta subunit interaction interface [polypeptide binding]; other site
1423144002691	Walker A motif; other site
1423144002692	ATP binding site [chemical binding]; other site
1423144002693	Walker B motif; other site
1423144002694	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1423144002695	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
1423144002696	core domain interface [polypeptide binding]; other site
1423144002697	delta subunit interface [polypeptide binding]; other site
1423144002698	epsilon subunit interface [polypeptide binding]; other site
1423144002699	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
1423144002700	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
1423144002701	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
1423144002702	alpha subunit interaction interface [polypeptide binding]; other site
1423144002703	Walker A motif; other site
1423144002704	ATP binding site [chemical binding]; other site
1423144002705	Walker B motif; other site
1423144002706	inhibitor binding site; inhibition site
1423144002707	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
1423144002708	F0F1 ATP synthase subunit epsilon; Provisional; Region: atpC; PRK13443
1423144002709	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
1423144002710	gamma subunit interface [polypeptide binding]; other site
1423144002711	epsilon subunit interface [polypeptide binding]; other site
1423144002712	LBP interface [polypeptide binding]; other site
1423144002713	H-type lectin domain; Region: H_lectin; pfam09458
1423144002714	Uncharacterized conserved protein [Function unknown]; Region: COG3791
1423144002715	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
1423144002716	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
1423144002717	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1423144002718	active site
1423144002719	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1423144002720	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
1423144002721	catalytic site [active]
1423144002722	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1423144002723	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144002724	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1423144002725	dimerization interface [polypeptide binding]; other site
1423144002726	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
1423144002727	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
1423144002728	tetramer interface [polypeptide binding]; other site
1423144002729	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144002730	catalytic residue [active]
1423144002731	hypothetical protein; Provisional; Region: PRK05170
1423144002732	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
1423144002733	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
1423144002734	active site
1423144002735	Riboflavin kinase; Region: Flavokinase; pfam01687
1423144002736	(R)-hydratase [(R)-specific enoyl-CoA hydratase] catalyzes the hydration of trans-2-enoyl CoA to (R)-3-hydroxyacyl-CoA as part of the PHA (polyhydroxyalkanoate) biosynthetic pathway. (R)-hydratase contains a hot-dog fold similar to those of thioesterase...; Region: R_hydratase; cd03449
1423144002737	dimer interaction site [polypeptide binding]; other site
1423144002738	substrate-binding tunnel; other site
1423144002739	active site
1423144002740	catalytic site [active]
1423144002741	substrate binding site [chemical binding]; other site
1423144002742	HAD-superfamily class IIA hydrolase, TIGR01459; Region: HAD-SF-IIA-hyp4
1423144002743	Haloacid dehalogenase-like hydrolase; Region: Hydrolase_6; pfam13344
1423144002744	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
1423144002745	HAMP domain; Region: HAMP; pfam00672
1423144002746	dimerization interface [polypeptide binding]; other site
1423144002747	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1423144002748	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1423144002749	dimer interface [polypeptide binding]; other site
1423144002750	putative CheW interface [polypeptide binding]; other site
1423144002751	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
1423144002752	DHH family; Region: DHH; pfam01368
1423144002753	DHHA2 domain; Region: DHHA2; pfam02833
1423144002754	Uncharacterized conserved protein (DUF2161); Region: DUF2161; pfam09929
1423144002755	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
1423144002756	oligomerisation interface [polypeptide binding]; other site
1423144002757	mobile loop; other site
1423144002758	roof hairpin; other site
1423144002759	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1423144002760	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1423144002761	ring oligomerisation interface [polypeptide binding]; other site
1423144002762	ATP/Mg binding site [chemical binding]; other site
1423144002763	stacking interactions; other site
1423144002764	hinge regions; other site
1423144002765	HNH endonuclease; Region: HNH_2; pfam13391
1423144002766	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1423144002767	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
1423144002768	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1423144002769	active site
1423144002770	phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019
1423144002771	ATP-grasp domain; Region: ATP-grasp; pfam02222
1423144002772	AIR carboxylase; Region: AIRC; pfam00731
1423144002773	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
1423144002774	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
1423144002775	putative dimer interface [polypeptide binding]; other site
1423144002776	Protein of unknown function (DUF1150); Region: DUF1150; pfam06620
1423144002777	Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384
1423144002778	Glycosyltransferase family 10 (fucosyltransferase); Region: Glyco_transf_10; pfam00852
1423144002779	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
1423144002780	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1423144002781	bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Validated; Region: PRK05537
1423144002782	ATP-sulfurylase; Region: ATPS; cd00517
1423144002783	active site
1423144002784	HXXH motif; other site
1423144002785	flexible loop; other site
1423144002786	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
1423144002787	ligand-binding site [chemical binding]; other site
1423144002788	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
1423144002789	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1423144002790	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1423144002791	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1423144002792	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1423144002793	putative DNA binding site [nucleotide binding]; other site
1423144002794	putative Zn2+ binding site [ion binding]; other site
1423144002795	AsnC family; Region: AsnC_trans_reg; pfam01037
1423144002796	Hint domain; Region: Hint_2; pfam13403
1423144002797	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
1423144002798	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; pfam02578
1423144002799	Uncharacterized conserved protein [Function unknown]; Region: COG1565
1423144002800	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
1423144002801	Membrane fusogenic activity; Region: BMFP; pfam04380
1423144002802	Putative bacterial sensory transduction regulator; Region: YbjN; cl15834
1423144002803	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
1423144002804	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
1423144002805	tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798
1423144002806	dimer interface [polypeptide binding]; other site
1423144002807	putative tRNA-binding site [nucleotide binding]; other site
1423144002808	D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301
1423144002809	dimerization interface [polypeptide binding]; other site
1423144002810	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
1423144002811	ligand binding site [chemical binding]; other site
1423144002812	NADP binding site [chemical binding]; other site
1423144002813	catalytic site [active]
1423144002814	thymidine kinase; Provisional; Region: PRK04296
1423144002815	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1423144002816	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
1423144002817	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07515
1423144002818	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1423144002819	dimer interface [polypeptide binding]; other site
1423144002820	active site
1423144002821	CoA binding pocket [chemical binding]; other site
1423144002822	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1423144002823	MarR family; Region: MarR; pfam01047
1423144002824	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1423144002825	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1423144002826	HlyD family secretion protein; Region: HlyD_3; pfam13437
1423144002827	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1423144002828	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
1423144002829	active site
1423144002830	Glycine/serine hydroxymethyltransferase [Amino acid transport and metabolism]; Region: GlyA; COG0112
1423144002831	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1423144002832	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1423144002833	catalytic residue [active]
1423144002834	putative choline sulfate-utilization transcription factor; Region: chol_sulf_TF; TIGR03418
1423144002835	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144002836	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1423144002837	dimerization interface [polypeptide binding]; other site
1423144002838	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
1423144002839	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1423144002840	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1423144002841	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
1423144002842	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1423144002843	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1423144002844	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
1423144002845	IMP binding site; other site
1423144002846	dimer interface [polypeptide binding]; other site
1423144002847	partial ornithine binding site; other site
1423144002848	aminodeoxychorismate synthase; Provisional; Region: PRK07508
1423144002849	chorismate binding enzyme; Region: Chorismate_bind; cl10555
1423144002850	hypothetical protein; Provisional; Region: PRK07546
1423144002851	substrate-cofactor binding pocket; other site
1423144002852	homodimer interface [polypeptide binding]; other site
1423144002853	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1423144002854	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144002855	catalytic residue [active]
1423144002856	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
1423144002857	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
1423144002858	dimer interface [polypeptide binding]; other site
1423144002859	anticodon binding site; other site
1423144002860	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1423144002861	motif 1; other site
1423144002862	dimer interface [polypeptide binding]; other site
1423144002863	active site
1423144002864	motif 2; other site
1423144002865	GAD domain; Region: GAD; pfam02938
1423144002866	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1423144002867	active site
1423144002868	motif 3; other site
1423144002869	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
1423144002870	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4102
1423144002871	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1423144002872	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144002873	active site
1423144002874	phosphorylation site [posttranslational modification]
1423144002875	intermolecular recognition site; other site
1423144002876	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1423144002877	Methylmalonyl-CoA epimerase (MMCE); Region: MMCE; cd07249
1423144002878	dimer interface [polypeptide binding]; other site
1423144002879	substrate binding site [chemical binding]; other site
1423144002880	metal binding site [ion binding]; metal-binding site
1423144002881	Protein of unknown function (DUF1467); Region: DUF1467; pfam07330
1423144002882	Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126
1423144002883	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
1423144002884	FMN binding site [chemical binding]; other site
1423144002885	dimer interface [polypeptide binding]; other site
1423144002886	Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811
1423144002887	Peptidase family M48; Region: Peptidase_M48; cl12018
1423144002888	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
1423144002889	Protein of unknown function, DUF393; Region: DUF393; pfam04134
1423144002890	ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862
1423144002891	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1423144002892	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1423144002893	FeS/SAM binding site; other site
1423144002894	Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982
1423144002895	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1423144002896	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
1423144002897	The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089
1423144002898	active site
1423144002899	substrate binding site [chemical binding]; other site
1423144002900	metal binding site [ion binding]; metal-binding site
1423144002901	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
1423144002902	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
1423144002903	polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010
1423144002904	ABC-type polysaccharide/polyol phosphate transport system, ATPase component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagH; COG1134
1423144002905	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1423144002906	Walker A/P-loop; other site
1423144002907	ATP binding site [chemical binding]; other site
1423144002908	Q-loop/lid; other site
1423144002909	ABC transporter signature motif; other site
1423144002910	Walker B; other site
1423144002911	D-loop; other site
1423144002912	H-loop/switch region; other site
1423144002913	Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483
1423144002914	ligand binding site [chemical binding]; other site
1423144002915	active site
1423144002916	putative S-transferase; Provisional; Region: PRK11752
1423144002917	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
1423144002918	C-terminal domain interface [polypeptide binding]; other site
1423144002919	GSH binding site (G-site) [chemical binding]; other site
1423144002920	dimer interface [polypeptide binding]; other site
1423144002921	C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292
1423144002922	dimer interface [polypeptide binding]; other site
1423144002923	N-terminal domain interface [polypeptide binding]; other site
1423144002924	active site
1423144002925	Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909
1423144002926	GcrA cell cycle regulator; Region: GcrA; cl11564
1423144002927	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1423144002928	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1423144002929	EamA-like transporter family; Region: EamA; pfam00892
1423144002930	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1423144002931	acetylornithine transaminase protein; Provisional; Region: argD; PRK01278
1423144002932	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1423144002933	inhibitor-cofactor binding pocket; inhibition site
1423144002934	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144002935	catalytic residue [active]
1423144002936	ornithine carbamoyltransferase; Provisional; Region: PRK00779
1423144002937	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1423144002938	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1423144002939	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
1423144002940	Phosphate transporter family; Region: PHO4; pfam01384
1423144002941	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_9; cd04666
1423144002942	nudix motif; other site
1423144002943	ATP-dependent helicase HrpB; Region: DEAH_box_HrpB; TIGR01970
1423144002944	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1423144002945	ATP binding site [chemical binding]; other site
1423144002946	putative Mg++ binding site [ion binding]; other site
1423144002947	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1423144002948	Helicase associated domain (HA2); Region: HA2; pfam04408
1423144002949	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
1423144002950	membrane ATPase/protein kinase; Provisional; Region: PRK09435
1423144002951	The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114
1423144002952	Walker A; other site
1423144002953	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
1423144002954	Protein of unknown function (DUF461); Region: DUF461; pfam04314
1423144002955	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1423144002956	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1423144002957	active site
1423144002958	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1423144002959	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144002960	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1423144002961	dimerization interface [polypeptide binding]; other site
1423144002962	GTP-binding protein LepA; Provisional; Region: PRK05433
1423144002963	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
1423144002964	G1 box; other site
1423144002965	putative GEF interaction site [polypeptide binding]; other site
1423144002966	GTP/Mg2+ binding site [chemical binding]; other site
1423144002967	Switch I region; other site
1423144002968	G2 box; other site
1423144002969	G3 box; other site
1423144002970	Switch II region; other site
1423144002971	G4 box; other site
1423144002972	G5 box; other site
1423144002973	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
1423144002974	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
1423144002975	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
1423144002976	Entericidin EcnA/B family; Region: Entericidin; cl02322
1423144002977	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
1423144002978	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
1423144002979	PhnA protein; Region: PhnA; pfam03831
1423144002980	Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518
1423144002981	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1423144002982	S-adenosylmethionine binding site [chemical binding]; other site
1423144002983	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
1423144002984	cobyric acid synthase; Provisional; Region: PRK00784
1423144002985	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1423144002986	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
1423144002987	catalytic triad [active]
1423144002988	elongation factor P; Validated; Region: PRK00529
1423144002989	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
1423144002990	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
1423144002991	RNA binding site [nucleotide binding]; other site
1423144002992	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
1423144002993	RNA binding site [nucleotide binding]; other site
1423144002994	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
1423144002995	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
1423144002996	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1423144002997	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1423144002998	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1423144002999	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1423144003000	Walker A/P-loop; other site
1423144003001	ATP binding site [chemical binding]; other site
1423144003002	Q-loop/lid; other site
1423144003003	ABC transporter signature motif; other site
1423144003004	Walker B; other site
1423144003005	D-loop; other site
1423144003006	H-loop/switch region; other site
1423144003007	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1423144003008	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1423144003009	catalytic residue [active]
1423144003010	histidinol-phosphate aminotransferase; Provisional; Region: PRK08153
1423144003011	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1423144003012	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144003013	homodimer interface [polypeptide binding]; other site
1423144003014	catalytic residue [active]
1423144003015	enoyl-CoA hydratase; Provisional; Region: PRK07509
1423144003016	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1423144003017	substrate binding site [chemical binding]; other site
1423144003018	oxyanion hole (OAH) forming residues; other site
1423144003019	trimer interface [polypeptide binding]; other site
1423144003020	fructose-1,6-bisphosphate aldolase; Reviewed; Region: PRK05377
1423144003021	catalytic residue [active]
1423144003022	CTP synthetase; Validated; Region: pyrG; PRK05380
1423144003023	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
1423144003024	Catalytic site [active]
1423144003025	active site
1423144003026	UTP binding site [chemical binding]; other site
1423144003027	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
1423144003028	active site
1423144003029	putative oxyanion hole; other site
1423144003030	catalytic triad [active]
1423144003031	Nitrile hydratase, alpha chain; Region: NHase_alpha; pfam02979
1423144003032	NHLP leader peptide domain; Region: TOMM_pelo; TIGR03793
1423144003033	Nitrile hydratase beta subunit; Region: NHase_beta; pfam02211
1423144003034	nitrile hydratase, beta subunit; Region: nitrile_beta; TIGR03888
1423144003035	nitrile hydratase accessory protein; Region: nitrile_acc; TIGR03889
1423144003036	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
1423144003037	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1423144003038	Histidine kinase; Region: HisKA_2; pfam07568
1423144003039	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1423144003040	ATP binding site [chemical binding]; other site
1423144003041	Mg2+ binding site [ion binding]; other site
1423144003042	G-X-G motif; other site
1423144003043	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
1423144003044	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
1423144003045	GDP-binding site [chemical binding]; other site
1423144003046	ACT binding site; other site
1423144003047	IMP binding site; other site
1423144003048	Protein of unknown function (DUF2842); Region: DUF2842; pfam11003
1423144003049	Thiamine pyrophosphokinase; Region: TPK; cd07995
1423144003050	active site
1423144003051	thiamine binding site [chemical binding]; other site
1423144003052	dimerization interface [polypeptide binding]; other site
1423144003053	EamA-like transporter family; Region: EamA; pfam00892
1423144003054	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1423144003055	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
1423144003056	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
1423144003057	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
1423144003058	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
1423144003059	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1423144003060	C-terminal domain interface [polypeptide binding]; other site
1423144003061	GSH binding site (G-site) [chemical binding]; other site
1423144003062	dimer interface [polypeptide binding]; other site
1423144003063	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1423144003064	N-terminal domain interface [polypeptide binding]; other site
1423144003065	dimer interface [polypeptide binding]; other site
1423144003066	substrate binding pocket (H-site) [chemical binding]; other site
1423144003067	Stress responsive A/B Barrel Domain; Region: Dabb; smart00886
1423144003068	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
1423144003069	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1423144003070	active site
1423144003071	dimer interface [polypeptide binding]; other site
1423144003072	AAA domain; Region: AAA_33; pfam13671
1423144003073	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1423144003074	active site
1423144003075	glutathione reductase; Validated; Region: PRK06116
1423144003076	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1423144003077	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1423144003078	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1423144003079	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
1423144003080	HflK protein; Region: hflK; TIGR01933
1423144003081	HflC protein; Region: hflC; TIGR01932
1423144003082	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
1423144003083	periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037
1423144003084	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1423144003085	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1423144003086	protein binding site [polypeptide binding]; other site
1423144003087	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
1423144003088	protein binding site [polypeptide binding]; other site
1423144003089	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1423144003090	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1423144003091	ligand binding site [chemical binding]; other site
1423144003092	flexible hinge region; other site
1423144003093	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1423144003094	putative switch regulator; other site
1423144003095	non-specific DNA interactions [nucleotide binding]; other site
1423144003096	DNA binding site [nucleotide binding]
1423144003097	sequence specific DNA binding site [nucleotide binding]; other site
1423144003098	putative cAMP binding site [chemical binding]; other site
1423144003099	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1423144003100	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
1423144003101	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1423144003102	catalytic loop [active]
1423144003103	iron binding site [ion binding]; other site
1423144003104	Family description; Region: VCBS; pfam13517
1423144003105	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
1423144003106	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
1423144003107	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
1423144003108	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
1423144003109	Protein of unknown function (DUF1217); Region: DUF1217; pfam06748
1423144003110	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1423144003111	PAS domain; Region: PAS_9; pfam13426
1423144003112	putative active site [active]
1423144003113	heme pocket [chemical binding]; other site
1423144003114	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1423144003115	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1423144003116	DNA binding residues [nucleotide binding]
1423144003117	dimerization interface [polypeptide binding]; other site
1423144003118	Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; pfam01062
1423144003119	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
1423144003120	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
1423144003121	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1423144003122	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
1423144003123	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
1423144003124	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
1423144003125	generic binding surface II; other site
1423144003126	generic binding surface I; other site
1423144003127	YhhN-like protein; Region: YhhN; pfam07947
1423144003128	signal recognition particle-docking protein FtsY; Region: ftsY; TIGR00064
1423144003129	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
1423144003130	P loop; other site
1423144003131	GTP binding site [chemical binding]; other site
1423144003132	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
1423144003133	EamA-like transporter family; Region: EamA; pfam00892
1423144003134	Intracellular septation protein A; Region: IspA; pfam04279
1423144003135	O-succinylhomoserine sulfhydrylase; Reviewed; Region: PRK07504
1423144003136	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1423144003137	homodimer interface [polypeptide binding]; other site
1423144003138	substrate-cofactor binding pocket; other site
1423144003139	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144003140	catalytic residue [active]
1423144003141	putative GTP cyclohydrolase; Provisional; Region: PRK13674
1423144003142	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
1423144003143	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1423144003144	aspartate kinase; Reviewed; Region: PRK06635
1423144003145	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
1423144003146	putative nucleotide binding site [chemical binding]; other site
1423144003147	putative catalytic residues [active]
1423144003148	putative Mg ion binding site [ion binding]; other site
1423144003149	putative aspartate binding site [chemical binding]; other site
1423144003150	ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913
1423144003151	putative allosteric regulatory site; other site
1423144003152	ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936
1423144003153	putative allosteric regulatory residue; other site
1423144003154	Signal transduction protein containing GAF and PtsI domains [Signal transduction mechanisms]; Region: PtsP; COG3605
1423144003155	GAF domain; Region: GAF; pfam01590
1423144003156	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
1423144003157	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1423144003158	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1423144003159	salicylyl-CoA 5-hydroxylase; Reviewed; Region: PRK08255
1423144003160	Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis.  Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932
1423144003161	active site
1423144003162	FMN binding site [chemical binding]; other site
1423144003163	substrate binding site [chemical binding]; other site
1423144003164	homotetramer interface [polypeptide binding]; other site
1423144003165	catalytic residue [active]
1423144003166	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1423144003167	classical (c) SDRs; Region: SDR_c; cd05233
1423144003168	NAD(P) binding site [chemical binding]; other site
1423144003169	active site
1423144003170	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1423144003171	MarR family; Region: MarR; pfam01047
1423144003172	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1423144003173	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1423144003174	substrate binding site [chemical binding]; other site
1423144003175	oxyanion hole (OAH) forming residues; other site
1423144003176	trimer interface [polypeptide binding]; other site
1423144003177	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1423144003178	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1423144003179	active site
1423144003180	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1423144003181	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
1423144003182	acyl-activating enzyme (AAE) consensus motif; other site
1423144003183	AMP binding site [chemical binding]; other site
1423144003184	active site
1423144003185	CoA binding site [chemical binding]; other site
1423144003186	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
1423144003187	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
1423144003188	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1423144003189	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1423144003190	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1423144003191	non-specific DNA binding site [nucleotide binding]; other site
1423144003192	salt bridge; other site
1423144003193	sequence-specific DNA binding site [nucleotide binding]; other site
1423144003194	HipA N-terminal domain; Region: Couple_hipA; pfam13657
1423144003195	Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550
1423144003196	HipA-like N-terminal domain; Region: HipA_N; pfam07805
1423144003197	HipA-like C-terminal domain; Region: HipA_C; pfam07804
1423144003198	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1423144003199	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144003200	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1423144003201	putative effector binding pocket; other site
1423144003202	dimerization interface [polypeptide binding]; other site
1423144003203	Predicted protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: COG3531
1423144003204	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1423144003205	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1423144003206	Ketosteroid isomerase-related protein [General function prediction only]; Region: COG3631
1423144003207	Predicted membrane protein [Function unknown]; Region: COG2259
1423144003208	Protocatechuate 3,4-dioxygenase (3,4-PCD) catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and beta-subunit and an Fe3+ ion...; Region: 3,4-PCD; cd03459
1423144003209	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1423144003210	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
1423144003211	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
1423144003212	INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190
1423144003213	Int/Topo IB signature motif; other site
1423144003214	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1423144003215	active site
1423144003216	DNA binding site [nucleotide binding]
1423144003217	Int/Topo IB signature motif; other site
1423144003218	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
1423144003219	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
1423144003220	pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188
1423144003221	Int/Topo IB signature motif; other site
1423144003222	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
1423144003223	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
1423144003224	DNA-binding interface [nucleotide binding]; DNA binding site
1423144003225	type IV secretion system T-DNA border endonuclease VirD2; Provisional; Region: PRK13863
1423144003226	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
1423144003227	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1423144003228	Walker A motif; other site
1423144003229	ATP binding site [chemical binding]; other site
1423144003230	Walker B motif; other site
1423144003231	Transposase domain (DUF772); Region: DUF772; pfam05598
1423144003232	Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751
1423144003233	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
1423144003234	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
1423144003235	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
1423144003236	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1423144003237	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1423144003238	DNA-binding site [nucleotide binding]; DNA binding site
1423144003239	The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866
1423144003240	Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618
1423144003241	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1423144003242	active site
1423144003243	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1423144003244	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144003245	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
1423144003246	substrate binding pocket [chemical binding]; other site
1423144003247	dimerization interface [polypeptide binding]; other site
1423144003248	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1423144003249	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1423144003250	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1423144003251	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
1423144003252	putative catalytic residues [active]
1423144003253	SnoaL-like domain; Region: SnoaL_3; pfam13474
1423144003254	SnoaL-like domain; Region: SnoaL_3; pfam13474
1423144003255	SnoaL-like domain; Region: SnoaL_2; pfam12680
1423144003256	SnoaL-like domain; Region: SnoaL_2; pfam12680
1423144003257	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1423144003258	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like3; cd05668
1423144003259	metal binding site [ion binding]; metal-binding site
1423144003260	putative dimer interface [polypeptide binding]; other site
1423144003261	Agmatinase and related proteins; Region: Agmatinase-like_2; cd11593
1423144003262	agmatinase; Region: agmatinase; TIGR01230
1423144003263	putative active site [active]
1423144003264	Mn binding site [ion binding]; other site
1423144003265	ornithine cyclodeaminase; Validated; Region: PRK07589
1423144003266	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
1423144003267	EamA-like transporter family; Region: EamA; pfam00892
1423144003268	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
1423144003269	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1423144003270	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144003271	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1423144003272	dimerization interface [polypeptide binding]; other site
1423144003273	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
1423144003274	Nucleoside recognition; Region: Gate; pfam07670
1423144003275	SnoaL-like domain; Region: SnoaL_3; pfam13474
1423144003276	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cd00531
1423144003277	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
1423144003278	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
1423144003279	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
1423144003280	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
1423144003281	Walker A motif; other site
1423144003282	hexamer interface [polypeptide binding]; other site
1423144003283	ATP binding site [chemical binding]; other site
1423144003284	Walker B motif; other site
1423144003285	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
1423144003286	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
1423144003287	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
1423144003288	VirB7 interaction site; other site
1423144003289	VirB8 protein; Region: VirB8; pfam04335
1423144003290	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1423144003291	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1423144003292	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1423144003293	catalytic residue [active]
1423144003294	type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929
1423144003295	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
1423144003296	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1423144003297	Walker A motif; other site
1423144003298	ATP binding site [chemical binding]; other site
1423144003299	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
1423144003300	TrbC/VIRB2 family; Region: TrbC; pfam04956
1423144003301	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1423144003302	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1423144003303	catalytic residue [active]
1423144003304	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
1423144003305	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1423144003306	putative DNA binding site [nucleotide binding]; other site
1423144003307	putative Zn2+ binding site [ion binding]; other site
1423144003308	AsnC family; Region: AsnC_trans_reg; pfam01037
1423144003309	diaminopropionate ammonia-lyase; Provisional; Region: PRK08206
1423144003310	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1423144003311	catalytic residue [active]
1423144003312	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1423144003313	MarR family; Region: MarR; pfam01047
1423144003314	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
1423144003315	heme binding pocket [chemical binding]; other site
1423144003316	MarR family; Region: MarR_2; cl17246
1423144003317	Catalase-like heme-binding proteins and protein domains; Region: catalase_like; cl09506
1423144003318	heme binding pocket [chemical binding]; other site
1423144003319	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
1423144003320	heme-binding site [chemical binding]; other site
1423144003321	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
1423144003322	Domain of unknown function (DUF1971); Region: DUF1971; cl17717
1423144003323	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
1423144003324	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
1423144003325	Low-spin heme binding site [chemical binding]; other site
1423144003326	Putative water exit pathway; other site
1423144003327	Binuclear center (active site) [active]
1423144003328	Putative proton exit pathway; other site
1423144003329	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
1423144003330	Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; pfam02433
1423144003331	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
1423144003332	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
1423144003333	Cytochrome c; Region: Cytochrom_C; pfam00034
1423144003334	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1423144003335	Transcriptional regulator; Region: Rrf2; cl17282
1423144003336	Rrf2 family protein; Region: rrf2_super; TIGR00738
1423144003337	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
1423144003338	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1423144003339	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
1423144003340	D-pathway; other site
1423144003341	Low-spin heme binding site [chemical binding]; other site
1423144003342	Putative water exit pathway; other site
1423144003343	Binuclear center (active site) [active]
1423144003344	K-pathway; other site
1423144003345	Putative proton exit pathway; other site
1423144003346	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
1423144003347	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
1423144003348	Cu(I) binding site [ion binding]; other site
1423144003349	Formate/nitrite transporter; Region: Form_Nir_trans; cl00927
1423144003350	Cytochrome c2 [Energy production and conversion]; Region: COG3474
1423144003351	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1423144003352	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1423144003353	DNA-binding site [nucleotide binding]; DNA binding site
1423144003354	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1423144003355	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144003356	homodimer interface [polypeptide binding]; other site
1423144003357	catalytic residue [active]
1423144003358	class II aldolase/adducin domain protein; Provisional; Region: PRK07090
1423144003359	intersubunit interface [polypeptide binding]; other site
1423144003360	active site
1423144003361	Zn2+ binding site [ion binding]; other site
1423144003362	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1423144003363	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1423144003364	inhibitor site; inhibition site
1423144003365	active site
1423144003366	dimer interface [polypeptide binding]; other site
1423144003367	catalytic residue [active]
1423144003368	Formate/nitrite transporter; Region: Form_Nir_trans; cl00927
1423144003369	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1423144003370	active site
1423144003371	SAM binding site [chemical binding]; other site
1423144003372	homodimer interface [polypeptide binding]; other site
1423144003373	HTH-like domain; Region: HTH_21; pfam13276
1423144003374	Integrase core domain; Region: rve; pfam00665
1423144003375	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144003376	Response regulator receiver domain; Region: Response_reg; pfam00072
1423144003377	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144003378	active site
1423144003379	phosphorylation site [posttranslational modification]
1423144003380	intermolecular recognition site; other site
1423144003381	dimerization interface [polypeptide binding]; other site
1423144003382	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1423144003383	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1423144003384	dimer interface [polypeptide binding]; other site
1423144003385	phosphorylation site [posttranslational modification]
1423144003386	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1423144003387	ATP binding site [chemical binding]; other site
1423144003388	Mg2+ binding site [ion binding]; other site
1423144003389	G-X-G motif; other site
1423144003390	Response regulator receiver domain; Region: Response_reg; pfam00072
1423144003391	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144003392	active site
1423144003393	phosphorylation site [posttranslational modification]
1423144003394	intermolecular recognition site; other site
1423144003395	dimerization interface [polypeptide binding]; other site
1423144003396	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1423144003397	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1423144003398	substrate binding pocket [chemical binding]; other site
1423144003399	membrane-bound complex binding site; other site
1423144003400	hinge residues; other site
1423144003401	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1423144003402	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1423144003403	substrate binding pocket [chemical binding]; other site
1423144003404	membrane-bound complex binding site; other site
1423144003405	hinge residues; other site
1423144003406	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144003407	dimer interface [polypeptide binding]; other site
1423144003408	conserved gate region; other site
1423144003409	ABC-ATPase subunit interface; other site
1423144003410	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1423144003411	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144003412	dimer interface [polypeptide binding]; other site
1423144003413	conserved gate region; other site
1423144003414	putative PBP binding loops; other site
1423144003415	ABC-ATPase subunit interface; other site
1423144003416	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1423144003417	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1423144003418	Walker A/P-loop; other site
1423144003419	ATP binding site [chemical binding]; other site
1423144003420	Q-loop/lid; other site
1423144003421	ABC transporter signature motif; other site
1423144003422	Walker B; other site
1423144003423	D-loop; other site
1423144003424	H-loop/switch region; other site
1423144003425	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1423144003426	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144003427	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1423144003428	dimerization interface [polypeptide binding]; other site
1423144003429	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
1423144003430	catalytic triad [active]
1423144003431	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
1423144003432	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1423144003433	Walker A/P-loop; other site
1423144003434	ATP binding site [chemical binding]; other site
1423144003435	Q-loop/lid; other site
1423144003436	ABC transporter signature motif; other site
1423144003437	Walker B; other site
1423144003438	D-loop; other site
1423144003439	H-loop/switch region; other site
1423144003440	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1423144003441	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1423144003442	Walker A/P-loop; other site
1423144003443	ATP binding site [chemical binding]; other site
1423144003444	Q-loop/lid; other site
1423144003445	ABC transporter signature motif; other site
1423144003446	Walker B; other site
1423144003447	D-loop; other site
1423144003448	H-loop/switch region; other site
1423144003449	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1423144003450	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1423144003451	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1423144003452	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1423144003453	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1423144003454	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144003455	dimer interface [polypeptide binding]; other site
1423144003456	conserved gate region; other site
1423144003457	putative PBP binding loops; other site
1423144003458	ABC-ATPase subunit interface; other site
1423144003459	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1423144003460	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
1423144003461	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
1423144003462	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144003463	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
1423144003464	dimerization interface [polypeptide binding]; other site
1423144003465	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
1423144003466	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
1423144003467	tetramer interface [polypeptide binding]; other site
1423144003468	heme binding pocket [chemical binding]; other site
1423144003469	NADPH binding site [chemical binding]; other site
1423144003470	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1423144003471	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1423144003472	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1423144003473	putative DNA binding site [nucleotide binding]; other site
1423144003474	putative Zn2+ binding site [ion binding]; other site
1423144003475	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
1423144003476	MOSC domain; Region: MOSC; pfam03473
1423144003477	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1423144003478	Transposase; Region: HTH_Tnp_1; pfam01527
1423144003479	HTH-like domain; Region: HTH_21; pfam13276
1423144003480	Integrase core domain; Region: rve; pfam00665
1423144003481	Arc-like DNA binding domain; Region: Arc; pfam03869
1423144003482	Mnt; Region: mnt; PHA01513
1423144003483	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
1423144003484	active site
1423144003485	catalytic residues [active]
1423144003486	DNA binding site [nucleotide binding]
1423144003487	Int/Topo IB signature motif; other site
1423144003488	Sirohydrochlorin ferrochelatase [Inorganic ion transport and metabolism]; Region: COG2138
1423144003489	Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416
1423144003490	putative active site [active]
1423144003491	PAS fold; Region: PAS_7; pfam12860
1423144003492	PAS fold; Region: PAS_7; pfam12860
1423144003493	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1423144003494	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1423144003495	dimer interface [polypeptide binding]; other site
1423144003496	phosphorylation site [posttranslational modification]
1423144003497	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1423144003498	ATP binding site [chemical binding]; other site
1423144003499	Mg2+ binding site [ion binding]; other site
1423144003500	G-X-G motif; other site
1423144003501	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1423144003502	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144003503	active site
1423144003504	phosphorylation site [posttranslational modification]
1423144003505	intermolecular recognition site; other site
1423144003506	dimerization interface [polypeptide binding]; other site
1423144003507	Uncharacterized conserved protein [Function unknown]; Region: COG3287
1423144003508	FIST N domain; Region: FIST; pfam08495
1423144003509	FIST C domain; Region: FIST_C; pfam10442
1423144003510	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1423144003511	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144003512	active site
1423144003513	phosphorylation site [posttranslational modification]
1423144003514	intermolecular recognition site; other site
1423144003515	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1423144003516	DNA binding residues [nucleotide binding]
1423144003517	dimerization interface [polypeptide binding]; other site
1423144003518	Carbon monoxide dehydrogenase subunit G (CoxG); Region: CoxG; cd05018
1423144003519	putative hydrophobic ligand binding site [chemical binding]; other site
1423144003520	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
1423144003521	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1423144003522	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1423144003523	Walker A/P-loop; other site
1423144003524	ATP binding site [chemical binding]; other site
1423144003525	Q-loop/lid; other site
1423144003526	ABC transporter signature motif; other site
1423144003527	Walker B; other site
1423144003528	D-loop; other site
1423144003529	H-loop/switch region; other site
1423144003530	AMP-binding domain protein; Validated; Region: PRK07529
1423144003531	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1423144003532	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_4; cd05944
1423144003533	acyl-activating enzyme (AAE) consensus motif; other site
1423144003534	putative AMP binding site [chemical binding]; other site
1423144003535	putative active site [active]
1423144003536	putative CoA binding site [chemical binding]; other site
1423144003537	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
1423144003538	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
1423144003539	substrate binding pocket [chemical binding]; other site
1423144003540	Uncharacterized conserved protein [Function unknown]; Region: COG3379
1423144003541	Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524
1423144003542	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1423144003543	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1423144003544	Walker A/P-loop; other site
1423144003545	ATP binding site [chemical binding]; other site
1423144003546	Q-loop/lid; other site
1423144003547	ABC transporter signature motif; other site
1423144003548	Walker B; other site
1423144003549	D-loop; other site
1423144003550	H-loop/switch region; other site
1423144003551	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1423144003552	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1423144003553	Walker A/P-loop; other site
1423144003554	ATP binding site [chemical binding]; other site
1423144003555	Q-loop/lid; other site
1423144003556	ABC transporter signature motif; other site
1423144003557	Walker B; other site
1423144003558	D-loop; other site
1423144003559	H-loop/switch region; other site
1423144003560	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1423144003561	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1423144003562	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1423144003563	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144003564	dimer interface [polypeptide binding]; other site
1423144003565	conserved gate region; other site
1423144003566	ABC-ATPase subunit interface; other site
1423144003567	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1423144003568	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144003569	dimer interface [polypeptide binding]; other site
1423144003570	conserved gate region; other site
1423144003571	ABC-ATPase subunit interface; other site
1423144003572	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1423144003573	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
1423144003574	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
1423144003575	putative active site [active]
1423144003576	dimerization interface [polypeptide binding]; other site
1423144003577	putative tRNAtyr binding site [nucleotide binding]; other site
1423144003578	Nitroreductase family. Members of this family utilize FMN as a cofactor and catalyze reduction of a variety of nitroaromatic compounds, including nitrofurans, nitrobenzens, nitrophenol, nitrobenzoate and quinones by using either NADH or NADPH as a source...; Region: Nitroreductase; cd02136
1423144003579	putative FMN binding site [chemical binding]; other site
1423144003580	RNA polymerase I-specific transcription initiation factor Rrn7; Region: RRN7; pfam11781
1423144003581	A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin.  Many of these band 7 domain-containing proteins are lipid raft-associated.  Individual...; Region: Band_7_5; cd03408
1423144003582	Domain of unknown function (DUF4339); Region: DUF4339; pfam14237
1423144003583	Protein of unknown function (DUF2927); Region: DUF2927; pfam11150
1423144003584	Toxic anion resistance protein (TelA); Region: TelA; pfam05816
1423144003585	5-bromo-4-chloroindolyl phosphate hydrolysis protein; Region: Halogen_Hydrol; cl02059
1423144003586	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
1423144003587	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1423144003588	RNA binding surface [nucleotide binding]; other site
1423144003589	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
1423144003590	active site
1423144003591	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
1423144003592	nucleoside/Zn binding site; other site
1423144003593	dimer interface [polypeptide binding]; other site
1423144003594	catalytic motif [active]
1423144003595	Methyladenine glycosylase; Region: Adenine_glyco; pfam03352
1423144003596	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1423144003597	Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446
1423144003598	aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034
1423144003599	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1423144003600	aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012
1423144003601	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
1423144003602	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1423144003603	amidase catalytic site [active]
1423144003604	Zn binding residues [ion binding]; other site
1423144003605	substrate binding site [chemical binding]; other site
1423144003606	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
1423144003607	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1423144003608	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1423144003609	Coenzyme A binding pocket [chemical binding]; other site
1423144003610	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
1423144003611	Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432
1423144003612	Domain of unknown function (DUF1127); Region: DUF1127; cl02276
1423144003613	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1423144003614	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144003615	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1423144003616	dimerization interface [polypeptide binding]; other site
1423144003617	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
1423144003618	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1423144003619	NAD(P) binding site [chemical binding]; other site
1423144003620	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1423144003621	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1423144003622	non-specific DNA binding site [nucleotide binding]; other site
1423144003623	salt bridge; other site
1423144003624	sequence-specific DNA binding site [nucleotide binding]; other site
1423144003625	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1423144003626	Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate,  or similar substrates; Region: Bacterial_IMPase_like_1; cd01641
1423144003627	active site
1423144003628	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
1423144003629	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
1423144003630	active site
1423144003631	putative substrate binding pocket [chemical binding]; other site
1423144003632	guanine deaminase; Provisional; Region: PRK09228
1423144003633	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
1423144003634	active site
1423144003635	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
1423144003636	MgtE intracellular N domain; Region: MgtE_N; smart00924
1423144003637	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
1423144003638	Divalent cation transporter; Region: MgtE; pfam01769
1423144003639	5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727
1423144003640	Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382
1423144003641	Bacterial capsule synthesis protein PGA_cap; Region: PGA_cap; smart00854
1423144003642	putative active site [active]
1423144003643	metal binding site [ion binding]; metal-binding site
1423144003644	homodimer binding site [polypeptide binding]; other site
1423144003645	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1423144003646	transmembrane helices; other site
1423144003647	TrkA-C domain; Region: TrkA_C; pfam02080
1423144003648	TrkA-C domain; Region: TrkA_C; pfam02080
1423144003649	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1423144003650	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1423144003651	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1423144003652	FAD binding domain; Region: FAD_binding_2; pfam00890
1423144003653	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
1423144003654	transmembrane helices; other site
1423144003655	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1423144003656	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1423144003657	TrkA-C domain; Region: TrkA_C; pfam02080
1423144003658	TrkA-C domain; Region: TrkA_C; pfam02080
1423144003659	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
1423144003660	hypothetical protein; Validated; Region: PRK00110
1423144003661	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1423144003662	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1423144003663	Coenzyme A binding pocket [chemical binding]; other site
1423144003664	Predicted periplasmic protein [Function unknown]; Region: COG3904
1423144003665	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
1423144003666	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144003667	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1423144003668	dimerization interface [polypeptide binding]; other site
1423144003669	Lysine efflux permease [General function prediction only]; Region: COG1279
1423144003670	Protein of unknown function (DUF1036); Region: DUF1036; cl02296
1423144003671	transcriptional repressor BetI; Region: betaine_BetI; TIGR03384
1423144003672	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1423144003673	BCCT family transporter; Region: BCCT; cl00569
1423144003674	Sulfatase; Region: Sulfatase; cl17466
1423144003675	choline-sulfatase; Region: chol_sulfatase; TIGR03417
1423144003676	Choline sulfatase enzyme C terminal; Region: Choline_sulf_C; pfam12411
1423144003677	betaine aldehyde dehydrogenase; Provisional; Region: PRK13252
1423144003678	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1423144003679	NAD(P) binding site [chemical binding]; other site
1423144003680	catalytic residues [active]
1423144003681	choline dehydrogenase; Validated; Region: PRK02106
1423144003682	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1423144003683	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1423144003684	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2841
1423144003685	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1423144003686	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1423144003687	non-specific DNA binding site [nucleotide binding]; other site
1423144003688	salt bridge; other site
1423144003689	sequence-specific DNA binding site [nucleotide binding]; other site
1423144003690	Predicted transcriptional regulator [General function prediction only]; Region: COG3800
1423144003691	Domain of unknown function (DUF955); Region: DUF955; pfam06114
1423144003692	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
1423144003693	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1423144003694	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
1423144003695	putative substrate translocation pore; other site
1423144003696	Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277
1423144003697	active site
1423144003698	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
1423144003699	Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799
1423144003700	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
1423144003701	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
1423144003702	Src Homology 3 domain superfamily; Region: SH3; cl17036
1423144003703	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
1423144003704	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1423144003705	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1423144003706	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1423144003707	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1423144003708	carboxyltransferase (CT) interaction site; other site
1423144003709	biotinylation site [posttranslational modification]; other site
1423144003710	Domain of unknown function (DUF4174); Region: DUF4174; pfam13778
1423144003711	methylmalonyl-CoA mutase; Reviewed; Region: PRK09426
1423144003712	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679
1423144003713	active site
1423144003714	substrate binding site [chemical binding]; other site
1423144003715	coenzyme B12 binding site [chemical binding]; other site
1423144003716	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
1423144003717	B12 binding site [chemical binding]; other site
1423144003718	cobalt ligand [ion binding]; other site
1423144003719	Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468
1423144003720	Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247
1423144003721	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1423144003722	Coenzyme A binding pocket [chemical binding]; other site
1423144003723	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
1423144003724	DnaJ-domain-containing proteins 1 [Posttranslational modification, protein turnover, chaperones]; Region: DjlA; COG1076
1423144003725	putative metal binding site [ion binding]; other site
1423144003726	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1423144003727	HSP70 interaction site [polypeptide binding]; other site
1423144003728	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1423144003729	putative catalytic site [active]
1423144003730	putative metal binding site [ion binding]; other site
1423144003731	putative phosphate binding site [ion binding]; other site
1423144003732	exopolyphosphatase; Region: exo_poly_only; TIGR03706
1423144003733	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1423144003734	ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593
1423144003735	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1423144003736	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
1423144003737	Domain of unknown function DUF20; Region: UPF0118; pfam01594
1423144003738	prolyl-tRNA synthetase; Provisional; Region: PRK12325
1423144003739	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
1423144003740	dimer interface [polypeptide binding]; other site
1423144003741	motif 1; other site
1423144003742	active site
1423144003743	motif 2; other site
1423144003744	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
1423144003745	active site
1423144003746	motif 3; other site
1423144003747	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
1423144003748	anticodon binding site; other site
1423144003749	lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212
1423144003750	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1423144003751	FtsX-like permease family; Region: FtsX; pfam02687
1423144003752	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1423144003753	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1423144003754	Walker A/P-loop; other site
1423144003755	ATP binding site [chemical binding]; other site
1423144003756	Q-loop/lid; other site
1423144003757	ABC transporter signature motif; other site
1423144003758	Walker B; other site
1423144003759	D-loop; other site
1423144003760	H-loop/switch region; other site
1423144003761	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
1423144003762	The MopB_3 CD includes a group of related uncharacterized bacterial and archaeal molybdopterin-binding oxidoreductase-like domains with a putative N-terminal iron-sulfur [4Fe-4S] cluster binding site and molybdopterin cofactor binding site. These members...; Region: MopB_3; cd02766
1423144003763	putative [4Fe-4S] binding site [ion binding]; other site
1423144003764	putative molybdopterin cofactor binding site [chemical binding]; other site
1423144003765	Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929
1423144003766	molybdopterin cofactor binding site; other site
1423144003767	Nucleoside 2-deoxyribosyltransferase; Region: Nuc_deoxyrib_tr; cl17818
1423144003768	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
1423144003769	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1423144003770	Mg2+ binding site [ion binding]; other site
1423144003771	G-X-G motif; other site
1423144003772	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
1423144003773	anchoring element; other site
1423144003774	dimer interface [polypeptide binding]; other site
1423144003775	ATP binding site [chemical binding]; other site
1423144003776	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
1423144003777	active site
1423144003778	metal binding site [ion binding]; metal-binding site
1423144003779	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
1423144003780	uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926
1423144003781	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
1423144003782	Conserved hypothetical protein (DUF2461); Region: DUF2461; cl02374
1423144003783	multidrug efflux protein; Reviewed; Region: PRK01766
1423144003784	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
1423144003785	cation binding site [ion binding]; other site
1423144003786	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1423144003787	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1423144003788	N-terminal domain interface [polypeptide binding]; other site
1423144003789	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1423144003790	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144003791	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1423144003792	dimerization interface [polypeptide binding]; other site
1423144003793	Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175
1423144003794	Clavaminic acid synthetase (CAS) -like;  CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cl00184
1423144003795	active site
1423144003796	iron coordination sites [ion binding]; other site
1423144003797	substrate binding pocket [chemical binding]; other site
1423144003798	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1423144003799	aspartate aminotransferase; Provisional; Region: PRK05764
1423144003800	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1423144003801	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144003802	homodimer interface [polypeptide binding]; other site
1423144003803	catalytic residue [active]
1423144003804	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1423144003805	sequence-specific DNA binding site [nucleotide binding]; other site
1423144003806	salt bridge; other site
1423144003807	Flavinator of succinate dehydrogenase; Region: Sdh5; pfam03937
1423144003808	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1423144003809	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1423144003810	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
1423144003811	dimer interface [polypeptide binding]; other site
1423144003812	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1423144003813	active site
1423144003814	metal binding site [ion binding]; metal-binding site
1423144003815	glutathione binding site [chemical binding]; other site
1423144003816	thymidylate synthase; Reviewed; Region: thyA; PRK01827
1423144003817	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
1423144003818	dimerization interface [polypeptide binding]; other site
1423144003819	active site
1423144003820	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
1423144003821	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
1423144003822	folate binding site [chemical binding]; other site
1423144003823	NADP+ binding site [chemical binding]; other site
1423144003824	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1423144003825	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1423144003826	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
1423144003827	active site
1423144003828	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
1423144003829	Carboxymuconolactone decarboxylase family; Region: CMD; cl00460
1423144003830	Uncharacterized conserved protein [Function unknown]; Region: COG5470
1423144003831	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1423144003832	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1423144003833	DNA-binding site [nucleotide binding]; DNA binding site
1423144003834	FCD domain; Region: FCD; pfam07729
1423144003835	Amino acid synthesis; Region: AA_synth; pfam06684
1423144003836	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1423144003837	Lipase.  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883
1423144003838	nucleophilic elbow; other site
1423144003839	catalytic triad; other site
1423144003840	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1423144003841	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1423144003842	nudix motif; other site
1423144003843	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1423144003844	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
1423144003845	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1423144003846	Uncharacterized Candidatus pelagibacter aldehyde dehydrogenase, DhaS-like; Region: ALDH_DhaS; cd07114
1423144003847	NAD(P) binding site [chemical binding]; other site
1423144003848	catalytic residues [active]
1423144003849	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1423144003850	DNA-binding site [nucleotide binding]; DNA binding site
1423144003851	RNA-binding motif; other site
1423144003852	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1423144003853	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
1423144003854	hypothetical protein; Provisional; Region: PRK05409
1423144003855	Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048
1423144003856	threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413
1423144003857	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
1423144003858	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1423144003859	Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771
1423144003860	active site
1423144003861	dimer interface [polypeptide binding]; other site
1423144003862	motif 1; other site
1423144003863	motif 2; other site
1423144003864	motif 3; other site
1423144003865	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
1423144003866	anticodon binding site; other site
1423144003867	Domain of unknown function (DUF4105); Region: DUF4105; pfam13387
1423144003868	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1423144003869	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1423144003870	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1423144003871	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251
1423144003872	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1423144003873	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1423144003874	polyhydroxyalkanoate depolymerase, intracellular; Region: PHB_depoly_PhaZ; TIGR01849
1423144003875	PHB de-polymerase C-terminus; Region: PHB_depo_C; pfam06850
1423144003876	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
1423144003877	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
1423144003878	polyhydroxyalkanoate synthesis repressor PhaR; Region: PHA_reg_PhaR; TIGR01848
1423144003879	PHB/PHA accumulation regulator DNA-binding domain; Region: PHB_acc_N; pfam07879
1423144003880	PHB accumulation regulatory domain; Region: PHB_acc; pfam05233
1423144003881	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
1423144003882	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
1423144003883	XdhC Rossmann domain; Region: XdhC_C; pfam13478
1423144003884	MoeA_like. This domain is similar to a domain found in a variety of proteins involved in biosynthesis of molybdopterin cofactor, like MoaB, MogA, and MoeA. There this domain is presumed to bind molybdopterin. The exact function of this subgroup is...; Region: MoeA_like; cd03522
1423144003885	putative MPT binding site; other site
1423144003886	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
1423144003887	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
1423144003888	catalytic loop [active]
1423144003889	iron binding site [ion binding]; other site
1423144003890	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1423144003891	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
1423144003892	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1423144003893	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1423144003894	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
1423144003895	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
1423144003896	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1423144003897	putative CheW interface [polypeptide binding]; other site
1423144003898	Long range pseudoknot
1423144003899	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
1423144003900	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
1423144003901	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
1423144003902	YodA lipocalin-like domain; Region: YodA; pfam09223
1423144003903	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1423144003904	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
1423144003905	FAD binding pocket [chemical binding]; other site
1423144003906	FAD binding motif [chemical binding]; other site
1423144003907	phosphate binding motif [ion binding]; other site
1423144003908	beta-alpha-beta structure motif; other site
1423144003909	NAD binding pocket [chemical binding]; other site
1423144003910	Bacterial protein of unknown function (DUF934); Region: DUF934; cl01526
1423144003911	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
1423144003912	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
1423144003913	Active Sites [active]
1423144003914	Sulfite reductase, beta subunit (hemoprotein) [Inorganic ion transport and metabolism]; Region: CysI; COG0155
1423144003915	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1423144003916	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1423144003917	Protein of unknown function (DUF2849); Region: DUF2849; pfam11011
1423144003918	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1423144003919	active site
1423144003920	SAM binding site [chemical binding]; other site
1423144003921	homodimer interface [polypeptide binding]; other site
1423144003922	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1423144003923	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1423144003924	putative DNA binding site [nucleotide binding]; other site
1423144003925	putative Zn2+ binding site [ion binding]; other site
1423144003926	AsnC family; Region: AsnC_trans_reg; pfam01037
1423144003927	sugar efflux transporter; Region: 2A0120; TIGR00899
1423144003928	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1423144003929	Cytochrome P450; Region: p450; cl12078
1423144003930	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
1423144003931	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1423144003932	dimer interface [polypeptide binding]; other site
1423144003933	phosphorylation site [posttranslational modification]
1423144003934	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1423144003935	ATP binding site [chemical binding]; other site
1423144003936	Mg2+ binding site [ion binding]; other site
1423144003937	G-X-G motif; other site
1423144003938	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1423144003939	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144003940	active site
1423144003941	phosphorylation site [posttranslational modification]
1423144003942	intermolecular recognition site; other site
1423144003943	dimerization interface [polypeptide binding]; other site
1423144003944	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1423144003945	Walker A motif; other site
1423144003946	ATP binding site [chemical binding]; other site
1423144003947	Walker B motif; other site
1423144003948	arginine finger; other site
1423144003949	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1423144003950	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1423144003951	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
1423144003952	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
1423144003953	DctM-like transporters; Region: DctM; pfam06808
1423144003954	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
1423144003955	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
1423144003956	triosephosphate isomerase; Provisional; Region: PRK14565
1423144003957	substrate binding site [chemical binding]; other site
1423144003958	dimer interface [polypeptide binding]; other site
1423144003959	catalytic triad [active]
1423144003960	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
1423144003961	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
1423144003962	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
1423144003963	active site
1423144003964	catalytic site [active]
1423144003965	FeS assembly SUF system protein; Region: SUF_assoc; TIGR02945
1423144003966	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1423144003967	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1423144003968	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1423144003969	Protein of unknown function (DUF1826); Region: DUF1826; pfam08856
1423144003970	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
1423144003971	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
1423144003972	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
1423144003973	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
1423144003974	ATP-dependent Lon protease, bacterial type [Posttranslational modification, protein turnover, chaperones]; Region: Lon; COG0466
1423144003975	Found in ATP-dependent protease La (LON); Region: LON; smart00464
1423144003976	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1423144003977	Walker A motif; other site
1423144003978	ATP binding site [chemical binding]; other site
1423144003979	Walker B motif; other site
1423144003980	arginine finger; other site
1423144003981	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
1423144003982	PAS fold; Region: PAS_3; pfam08447
1423144003983	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1423144003984	putative active site [active]
1423144003985	heme pocket [chemical binding]; other site
1423144003986	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1423144003987	PAS fold; Region: PAS_3; pfam08447
1423144003988	putative active site [active]
1423144003989	heme pocket [chemical binding]; other site
1423144003990	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1423144003991	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1423144003992	dimer interface [polypeptide binding]; other site
1423144003993	putative CheW interface [polypeptide binding]; other site
1423144003994	YrhK-like protein; Region: YrhK; pfam14145
1423144003995	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
1423144003996	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1423144003997	NAD(P) binding domain of leucine dehydrogenase, phenylalanine dehydrogenase, and valine dehydrogenase; Region: NAD_bind_Leu_Phe_Val_DH; cd01075
1423144003998	NAD binding site [chemical binding]; other site
1423144003999	Phe binding site; other site
1423144004000	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1423144004001	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1423144004002	dimerization interface [polypeptide binding]; other site
1423144004003	putative DNA binding site [nucleotide binding]; other site
1423144004004	putative Zn2+ binding site [ion binding]; other site
1423144004005	AsnC family; Region: AsnC_trans_reg; pfam01037
1423144004006	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1423144004007	catalytic core [active]
1423144004008	hypothetical protein; Validated; Region: PRK09104
1423144004009	Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680
1423144004010	metal binding site [ion binding]; metal-binding site
1423144004011	putative dimer interface [polypeptide binding]; other site
1423144004012	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1423144004013	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1423144004014	substrate-cofactor binding pocket; other site
1423144004015	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144004016	catalytic residue [active]
1423144004017	Helix-turn-helix domain; Region: HTH_25; pfam13413
1423144004018	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
1423144004019	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
1423144004020	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
1423144004021	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
1423144004022	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1423144004023	catalytic residues [active]
1423144004024	Peptidase family M48; Region: Peptidase_M48; cl12018
1423144004025	TPR repeat; Region: TPR_11; pfam13414
1423144004026	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1423144004027	TPR motif; other site
1423144004028	TPR repeat; Region: TPR_11; pfam13414
1423144004029	binding surface
1423144004030	aspartate aminotransferase; Provisional; Region: PRK05764
1423144004031	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1423144004032	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144004033	homodimer interface [polypeptide binding]; other site
1423144004034	catalytic residue [active]
1423144004035	AMIN domain; Region: AMIN; pfam11741
1423144004036	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
1423144004037	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
1423144004038	active site
1423144004039	metal binding site [ion binding]; metal-binding site
1423144004040	Membrane carboxypeptidase/penicillin-binding protein [Cell envelope biogenesis, outer membrane]; Region: MrcA; COG5009
1423144004041	Transglycosylase; Region: Transgly; pfam00912
1423144004042	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1423144004043	peptide chain release factor 2; Validated; Region: prfB; PRK00578
1423144004044	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1423144004045	RF-1 domain; Region: RF-1; pfam00472
1423144004046	amidase; Provisional; Region: PRK07486
1423144004047	Amidase; Region: Amidase; cl11426
1423144004048	Predicted integral membrane protein (DUF2189); Region: DUF2189; pfam09955
1423144004049	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1423144004050	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1423144004051	non-specific DNA binding site [nucleotide binding]; other site
1423144004052	sequence-specific DNA binding site [nucleotide binding]; other site
1423144004053	salt bridge; other site
1423144004054	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
1423144004055	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
1423144004056	putative valine binding site [chemical binding]; other site
1423144004057	dimer interface [polypeptide binding]; other site
1423144004058	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
1423144004059	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK09107
1423144004060	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1423144004061	PYR/PP interface [polypeptide binding]; other site
1423144004062	dimer interface [polypeptide binding]; other site
1423144004063	TPP binding site [chemical binding]; other site
1423144004064	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1423144004065	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
1423144004066	TPP-binding site [chemical binding]; other site
1423144004067	dimer interface [polypeptide binding]; other site
1423144004068	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1423144004069	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144004070	active site
1423144004071	phosphorylation site [posttranslational modification]
1423144004072	intermolecular recognition site; other site
1423144004073	dimerization interface [polypeptide binding]; other site
1423144004074	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1423144004075	DNA binding residues [nucleotide binding]
1423144004076	dimerization interface [polypeptide binding]; other site
1423144004077	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4564
1423144004078	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
1423144004079	Histidine kinase; Region: HisKA_3; pfam07730
1423144004080	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1423144004081	ATP binding site [chemical binding]; other site
1423144004082	Mg2+ binding site [ion binding]; other site
1423144004083	G-X-G motif; other site
1423144004084	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
1423144004085	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
1423144004086	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
1423144004087	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
1423144004088	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
1423144004089	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1423144004090	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
1423144004091	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
1423144004092	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
1423144004093	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
1423144004094	RDD family; Region: RDD; pfam06271
1423144004095	Protein of unknown function (DUF2852); Region: DUF2852; pfam11014
1423144004096	Catalytic domain of type II restriction endonucleases BfiI and NgoFVII, and uncharacterized proteins with a DEAD domain; Region: PLDc_Bfil_DEXD_like; cd09117
1423144004097	PLD-like domain; Region: PLDc_2; pfam13091
1423144004098	homodimer interface [polypeptide binding]; other site
1423144004099	putative active site [active]
1423144004100	catalytic site [active]
1423144004101	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1423144004102	putative active site [active]
1423144004103	Lin1944 and related proteins, classical (c) SDRs; Region: Lin1944_like_SDR_c; cd11731
1423144004104	putative NAD(P) binding site [chemical binding]; other site
1423144004105	homodimer interface [polypeptide binding]; other site
1423144004106	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1423144004107	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1423144004108	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144004109	LysR substrate binding domain; Region: LysR_substrate; pfam03466
1423144004110	dimerization interface [polypeptide binding]; other site
1423144004111	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3224
1423144004112	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1423144004113	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1423144004114	probable polyamine oxidase; Region: PLN02268
1423144004115	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1423144004116	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1423144004117	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1423144004118	FOG: WD40 repeat [General function prediction only]; Region: COG2319
1423144004119	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
1423144004120	structural tetrad; other site
1423144004121	RNA polymerase sigma-54 factor; Region: rpoN_sigma; TIGR02395
1423144004122	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
1423144004123	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
1423144004124	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
1423144004125	Aromatic and Alkene Monooxygenase Hydroxylase, subunit A, ferritin-like diiron-binding domain; Region: AAMH_A; cd01057
1423144004126	dimerization interface [polypeptide binding]; other site
1423144004127	putative path to active site cavity [active]
1423144004128	diiron center [ion binding]; other site
1423144004129	CDP-6-deoxy-delta-3,4-glucoseen reductase; Validated; Region: PRK07609
1423144004130	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1423144004131	catalytic loop [active]
1423144004132	iron binding site [ion binding]; other site
1423144004133	Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868
1423144004134	FAD binding pocket [chemical binding]; other site
1423144004135	conserved FAD binding motif [chemical binding]; other site
1423144004136	phosphate binding motif [ion binding]; other site
1423144004137	beta-alpha-beta structure motif; other site
1423144004138	NAD binding pocket [chemical binding]; other site
1423144004139	Aromatic and Alkene Monooxygenase Hydroxylase, subunit B, ferritin-like diiron-binding domain; Region: AAMH_B; cd01058
1423144004140	dimerization interface [polypeptide binding]; other site
1423144004141	MmoB/DmpM family; Region: MmoB_DmpM; pfam02406
1423144004142	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cd01292
1423144004143	active site
1423144004144	Domain of unknown function DUF59; Region: DUF59; pfam01883
1423144004145	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
1423144004146	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
1423144004147	ring oligomerisation interface [polypeptide binding]; other site
1423144004148	ATP/Mg binding site [chemical binding]; other site
1423144004149	stacking interactions; other site
1423144004150	hinge regions; other site
1423144004151	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
1423144004152	classical (c) SDRs; Region: SDR_c; cd05233
1423144004153	NAD(P) binding site [chemical binding]; other site
1423144004154	active site
1423144004155	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1423144004156	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
1423144004157	dimer interface [polypeptide binding]; other site
1423144004158	active site
1423144004159	metal binding site [ion binding]; metal-binding site
1423144004160	glutathione binding site [chemical binding]; other site
1423144004161	Gluconate 2-dehydrogenase subunit 3; Region: Gluconate_2-dh3; pfam13618
1423144004162	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
1423144004163	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1423144004164	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
1423144004165	N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649
1423144004166	dimer interface [polypeptide binding]; other site
1423144004167	active site
1423144004168	heme binding site [chemical binding]; other site
1423144004169	C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200
1423144004170	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
1423144004171	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1423144004172	Walker A motif; other site
1423144004173	ATP binding site [chemical binding]; other site
1423144004174	Walker B motif; other site
1423144004175	arginine finger; other site
1423144004176	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1423144004177	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1423144004178	FAD binding domain; Region: FAD_binding_4; pfam01565
1423144004179	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1423144004180	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144004181	dimer interface [polypeptide binding]; other site
1423144004182	conserved gate region; other site
1423144004183	putative PBP binding loops; other site
1423144004184	ABC-ATPase subunit interface; other site
1423144004185	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144004186	dimer interface [polypeptide binding]; other site
1423144004187	conserved gate region; other site
1423144004188	putative PBP binding loops; other site
1423144004189	ABC-ATPase subunit interface; other site
1423144004190	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1423144004191	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1423144004192	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1423144004193	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1423144004194	Walker A/P-loop; other site
1423144004195	ATP binding site [chemical binding]; other site
1423144004196	Q-loop/lid; other site
1423144004197	ABC transporter signature motif; other site
1423144004198	Walker B; other site
1423144004199	D-loop; other site
1423144004200	H-loop/switch region; other site
1423144004201	TOBE domain; Region: TOBE_2; pfam08402
1423144004202	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1423144004203	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144004204	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1423144004205	dimerization interface [polypeptide binding]; other site
1423144004206	substrate binding pocket [chemical binding]; other site
1423144004207	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
1423144004208	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
1423144004209	active site
1423144004210	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
1423144004211	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1423144004212	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
1423144004213	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Provisional; Region: PRK14108
1423144004214	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1423144004215	metal binding triad; other site
1423144004216	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1423144004217	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
1423144004218	metal binding triad; other site
1423144004219	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
1423144004220	Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092
1423144004221	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
1423144004222	putative RNA binding site [nucleotide binding]; other site
1423144004223	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1423144004224	S-adenosylmethionine binding site [chemical binding]; other site
1423144004225	PIN domain; Region: PIN_3; pfam13470
1423144004226	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1423144004227	luciferase family oxidoreductase, group 1; Region: oxido_grp_1; TIGR03558
1423144004228	Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501
1423144004229	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
1423144004230	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
1423144004231	homodimer interface [polypeptide binding]; other site
1423144004232	metal binding site [ion binding]; metal-binding site
1423144004233	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
1423144004234	homodimer interface [polypeptide binding]; other site
1423144004235	active site
1423144004236	putative chemical substrate binding site [chemical binding]; other site
1423144004237	metal binding site [ion binding]; metal-binding site
1423144004238	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1423144004239	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
1423144004240	metal binding site [ion binding]; metal-binding site
1423144004241	putative dimer interface [polypeptide binding]; other site
1423144004242	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
1423144004243	agmatinase; Region: agmatinase; TIGR01230
1423144004244	oligomer interface [polypeptide binding]; other site
1423144004245	putative active site [active]
1423144004246	Mn binding site [ion binding]; other site
1423144004247	Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592
1423144004248	agmatinase; Region: agmatinase; TIGR01230
1423144004249	oligomer interface [polypeptide binding]; other site
1423144004250	putative active site [active]
1423144004251	Mn binding site [ion binding]; other site
1423144004252	Protein of unknown function (DUF1499); Region: DUF1499; pfam07386
1423144004253	peptide chain release factor 1; Validated; Region: prfA; PRK00591
1423144004254	This domain is found in peptide chain release factors; Region: PCRF; smart00937
1423144004255	RF-1 domain; Region: RF-1; pfam00472
1423144004256	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
1423144004257	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1423144004258	S-adenosylmethionine binding site [chemical binding]; other site
1423144004259	Domain of unknown function (DUF4167); Region: DUF4167; pfam13763
1423144004260	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
1423144004261	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
1423144004262	4-hydroxythreonine-4-phosphate dehydrogenase; Provisional; Region: pdxA; PRK05312
1423144004263	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
1423144004264	SurA N-terminal domain; Region: SurA_N; pfam09312
1423144004265	Organic solvent tolerance protein OstA [Cell envelope biogenesis, outer membrane]; Region: Imp; COG1452
1423144004266	OstA-like protein; Region: OstA; cl00844
1423144004267	Organic solvent tolerance protein; Region: OstA_C; pfam04453
1423144004268	Predicted permeases [General function prediction only]; Region: COG0795
1423144004269	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1423144004270	Predicted permeases [General function prediction only]; Region: COG0795
1423144004271	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
1423144004272	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
1423144004273	multifunctional aminopeptidase A; Provisional; Region: PRK00913
1423144004274	interface (dimer of trimers) [polypeptide binding]; other site
1423144004275	Substrate-binding/catalytic site; other site
1423144004276	Zn-binding sites [ion binding]; other site
1423144004277	DNA polymerase III subunit chi; Validated; Region: PRK05728
1423144004278	Predicted aspartyl protease [General function prediction only]; Region: COG3577
1423144004279	Bacterial aspartate proteases, retropepsin-like protease family; Region: retropepsin_like_bacteria; cd05483
1423144004280	catalytic motif [active]
1423144004281	Catalytic residue [active]
1423144004282	MarC family integral membrane protein; Region: MarC; pfam01914
1423144004283	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1423144004284	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
1423144004285	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1423144004286	ABC transporter; Region: ABC_tran_2; pfam12848
1423144004287	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1423144004288	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
1423144004289	active site
1423144004290	multimer interface [polypeptide binding]; other site
1423144004291	Domain of unknown function (DUF4112); Region: DUF4112; pfam13430
1423144004292	Proteolipid membrane potential modulator; Region: Pmp3; pfam01679
1423144004293	TfoX C-terminal domain; Region: TfoX_C; pfam04994
1423144004294	mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460
1423144004295	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1423144004296	active site
1423144004297	Cupin domain; Region: Cupin_2; cl17218
1423144004298	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1423144004299	high affinity sulphate transporter 1; Region: sulP; TIGR00815
1423144004300	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1423144004301	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1423144004302	Protein of unknown function (DUF2892); Region: DUF2892; pfam11127
1423144004303	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1423144004304	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1423144004305	ligand binding site [chemical binding]; other site
1423144004306	flexible hinge region; other site
1423144004307	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
1423144004308	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654
1423144004309	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
1423144004310	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
1423144004311	Protein of unknown function (DUF2474); Region: DUF2474; pfam10617
1423144004312	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1423144004313	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144004314	active site
1423144004315	phosphorylation site [posttranslational modification]
1423144004316	intermolecular recognition site; other site
1423144004317	dimerization interface [polypeptide binding]; other site
1423144004318	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1423144004319	DNA binding residues [nucleotide binding]
1423144004320	dimerization interface [polypeptide binding]; other site
1423144004321	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1423144004322	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1423144004323	putative active site [active]
1423144004324	heme pocket [chemical binding]; other site
1423144004325	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1423144004326	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1423144004327	dimer interface [polypeptide binding]; other site
1423144004328	phosphorylation site [posttranslational modification]
1423144004329	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1423144004330	ATP binding site [chemical binding]; other site
1423144004331	Mg2+ binding site [ion binding]; other site
1423144004332	G-X-G motif; other site
1423144004333	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1423144004334	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144004335	active site
1423144004336	phosphorylation site [posttranslational modification]
1423144004337	intermolecular recognition site; other site
1423144004338	dimerization interface [polypeptide binding]; other site
1423144004339	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cl00086
1423144004340	putative binding surface; other site
1423144004341	active site
1423144004342	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1423144004343	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1423144004344	ligand binding site [chemical binding]; other site
1423144004345	flexible hinge region; other site
1423144004346	Crp-like helix-turn-helix domain; Region: HTH_Crp_2; pfam13545
1423144004347	putative switch regulator; other site
1423144004348	non-specific DNA interactions [nucleotide binding]; other site
1423144004349	DNA binding site [nucleotide binding]
1423144004350	sequence specific DNA binding site [nucleotide binding]; other site
1423144004351	putative cAMP binding site [chemical binding]; other site
1423144004352	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
1423144004353	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1423144004354	FMN binding site [chemical binding]; other site
1423144004355	active site
1423144004356	catalytic residues [active]
1423144004357	substrate binding site [chemical binding]; other site
1423144004358	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1423144004359	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
1423144004360	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
1423144004361	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
1423144004362	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
1423144004363	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
1423144004364	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1423144004365	Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267
1423144004366	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
1423144004367	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
1423144004368	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1423144004369	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
1423144004370	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
1423144004371	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
1423144004372	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
1423144004373	Protein required for attachment to host cells; Region: Host_attach; pfam10116
1423144004374	Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695
1423144004375	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1423144004376	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1423144004377	ABC-type transport system involved in Fe-S cluster assembly, permease and ATPase components [Posttranslational modification, protein turnover, chaperones]; Region: ATM1; COG5265
1423144004378	ATP-binding cassette domain of iron-sulfur clusters transporter, subfamily C; Region: ABCC_ATM1_transporter; cd03253
1423144004379	Walker A/P-loop; other site
1423144004380	ATP binding site [chemical binding]; other site
1423144004381	Q-loop/lid; other site
1423144004382	ABC transporter signature motif; other site
1423144004383	Walker B; other site
1423144004384	D-loop; other site
1423144004385	H-loop/switch region; other site
1423144004386	AcrB/AcrD/AcrF family; Region: ACR_tran; pfam00873
1423144004387	Protein export membrane protein; Region: SecD_SecF; cl14618
1423144004388	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1423144004389	HlyD family secretion protein; Region: HlyD_3; pfam13437
1423144004390	PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493
1423144004391	Trp docking motif [polypeptide binding]; other site
1423144004392	active site
1423144004393	PQQ-like domain; Region: PQQ_2; pfam13360
1423144004394	PQQ-like domain; Region: PQQ_2; pfam13360
1423144004395	GTP-binding protein Der; Reviewed; Region: PRK00093
1423144004396	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
1423144004397	G1 box; other site
1423144004398	GTP/Mg2+ binding site [chemical binding]; other site
1423144004399	Switch I region; other site
1423144004400	G2 box; other site
1423144004401	Switch II region; other site
1423144004402	G3 box; other site
1423144004403	G4 box; other site
1423144004404	G5 box; other site
1423144004405	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
1423144004406	G1 box; other site
1423144004407	GTP/Mg2+ binding site [chemical binding]; other site
1423144004408	Switch I region; other site
1423144004409	G2 box; other site
1423144004410	G3 box; other site
1423144004411	Switch II region; other site
1423144004412	G4 box; other site
1423144004413	G5 box; other site
1423144004414	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
1423144004415	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
1423144004416	putative di-iron ligands [ion binding]; other site
1423144004417	Y-family of DNA polymerases; Region: PolY; cl12025
1423144004418	seryl-tRNA synthetase; Provisional; Region: PRK05431
1423144004419	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
1423144004420	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
1423144004421	dimer interface [polypeptide binding]; other site
1423144004422	active site
1423144004423	motif 1; other site
1423144004424	motif 2; other site
1423144004425	motif 3; other site
1423144004426	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1423144004427	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1423144004428	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1423144004429	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
1423144004430	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1423144004431	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1423144004432	Preprotein translocase subunit; Region: YajC; pfam02699
1423144004433	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
1423144004434	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
1423144004435	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
1423144004436	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
1423144004437	Protein export membrane protein; Region: SecD_SecF; pfam02355
1423144004438	Mth938-like domain. The members of this family include: Mth938, 2P1, Xcr35, Rpa2829, and several uncharacterized sequences. Mth938 is a hypothetical protein encoded by the Methanobacterium thermoautotrophicum (Mth) genome. This protein crystallizes as a...; Region: Mth938-like; cd00248
1423144004439	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1423144004440	Walker A/P-loop; other site
1423144004441	ATP binding site [chemical binding]; other site
1423144004442	ABC transporter; Region: ABC_tran; pfam00005
1423144004443	Q-loop/lid; other site
1423144004444	ABC transporter signature motif; other site
1423144004445	Walker B; other site
1423144004446	D-loop; other site
1423144004447	heme exporter protein CcmB; Region: ccmB; TIGR01190
1423144004448	heme exporter protein CcmC; Region: ccmC; TIGR01191
1423144004449	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
1423144004450	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1423144004451	catalytic residues [active]
1423144004452	central insert; other site
1423144004453	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
1423144004454	aconitate hydratase; Validated; Region: PRK09277
1423144004455	Aconitase A catalytic domain; Region: AcnA_IRP; cd01586
1423144004456	substrate binding site [chemical binding]; other site
1423144004457	ligand binding site [chemical binding]; other site
1423144004458	Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580
1423144004459	substrate binding site [chemical binding]; other site
1423144004460	Protein of unknown function (DUF1223); Region: DUF1223; pfam06764
1423144004461	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
1423144004462	putative acyl-acceptor binding pocket; other site
1423144004463	Flagellar motor switch protein [Cell motility and secretion]; Region: FliG; COG1536
1423144004464	FliG C-terminal domain; Region: FliG_C; pfam01706
1423144004465	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1423144004466	TPR motif; other site
1423144004467	adenylosuccinate lyase; Provisional; Region: PRK07492
1423144004468	Adenylsuccinate lyase (ASL)_subgroup 1; Region: Adenylsuccinate_lyase_1; cd01360
1423144004469	tetramer interface [polypeptide binding]; other site
1423144004470	active site
1423144004471	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1423144004472	Predicted redox protein, regulator of disulfide bond formation [Posttranslational modification, protein turnover, chaperones]; Region: COG1765
1423144004473	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674
1423144004474	nudix motif; other site
1423144004475	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1423144004476	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1423144004477	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
1423144004478	active site
1423144004479	Protein of unknown function (DUF3445); Region: DUF3445; pfam11927
1423144004480	glutamine synthetase; Provisional; Region: glnA; PRK09469
1423144004481	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1423144004482	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1423144004483	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
1423144004484	Nitrogen regulatory protein P-II; Region: P-II; smart00938
1423144004485	Uncharacterized conserved protein [Function unknown]; Region: COG0062
1423144004486	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
1423144004487	putative substrate binding site [chemical binding]; other site
1423144004488	putative ATP binding site [chemical binding]; other site
1423144004489	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1423144004490	dimer interface [polypeptide binding]; other site
1423144004491	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
1423144004492	putative CheW interface [polypeptide binding]; other site
1423144004493	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1423144004494	trigger factor; Provisional; Region: tig; PRK01490
1423144004495	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1423144004496	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
1423144004497	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
1423144004498	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
1423144004499	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
1423144004500	active site
1423144004501	metal binding site [ion binding]; metal-binding site
1423144004502	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1423144004503	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1423144004504	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1423144004505	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1423144004506	catalytic residue [active]
1423144004507	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
1423144004508	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
1423144004509	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
1423144004510	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
1423144004511	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
1423144004512	Uncharacterized conserved protein [Function unknown]; Region: COG2353
1423144004513	YCII-related domain; Region: YCII; cl00999
1423144004514	FRG domain; Region: FRG; pfam08867
1423144004515	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
1423144004516	YceI-like domain; Region: YceI; pfam04264
1423144004517	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1423144004518	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1423144004519	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1423144004520	3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830
1423144004521	NAD(P) binding site [chemical binding]; other site
1423144004522	homotetramer interface [polypeptide binding]; other site
1423144004523	homodimer interface [polypeptide binding]; other site
1423144004524	active site
1423144004525	acyl carrier protein; Provisional; Region: acpP; PRK00982
1423144004526	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1423144004527	phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007
1423144004528	catalytic residues [active]
1423144004529	PilZ domain; Region: PilZ; pfam07238
1423144004530	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314
1423144004531	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1423144004532	dimer interface [polypeptide binding]; other site
1423144004533	active site
1423144004534	YceG-like family; Region: YceG; pfam02618
1423144004535	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
1423144004536	dimerization interface [polypeptide binding]; other site
1423144004537	Uncharacterized conserved protein [Function unknown]; Region: COG5323
1423144004538	Terminase-like family; Region: Terminase_6; pfam03237
1423144004539	Phage-related protein [Function unknown]; Region: COG4695
1423144004540	Phage portal protein; Region: Phage_portal; pfam04860
1423144004541	Caudovirus prohead protease; Region: Peptidase_U35; pfam04586
1423144004542	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
1423144004543	Phage capsid family; Region: Phage_capsid; pfam05065
1423144004544	phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215
1423144004545	Head-Tail Connector Proteins gp6 and gp15, and similar proteins; Region: gp6_gp15_like; cl12049
1423144004546	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
1423144004547	oligomerization interface [polypeptide binding]; other site
1423144004548	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
1423144004549	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
1423144004550	Phage major tail protein 2; Region: Phage_tail_2; cl11463
1423144004551	Protein of unknown function (DUF3356); Region: DUF3356; pfam11836
1423144004552	phage conserved hypothetical protein; Region: phage_TIGR02216
1423144004553	Phage-related minor tail protein [Function unknown]; Region: COG5281
1423144004554	Conserved hypothetical protein 2217 (DUF2460); Region: DUF2460; pfam09343
1423144004555	Uncharacterized conserved protein (DUF2163); Region: DUF2163; pfam09931
1423144004556	phage conserved hypothetical protein BR0599; Region: phg_TIGR02218
1423144004557	Phage conserved hypothetical protein BR0599; Region: Phage_BR0599; pfam09356
1423144004558	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
1423144004559	NlpC/P60 family; Region: NLPC_P60; cl17555
1423144004560	GTA TIM-barrel-like domain; Region: GTA_TIM; pfam13547
1423144004561	Putative phage tail protein; Region: Phage-tail_3; pfam13550
1423144004562	serine acetyltransferase; Provisional; Region: cysE; PRK11132
1423144004563	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
1423144004564	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
1423144004565	trimer interface [polypeptide binding]; other site
1423144004566	active site
1423144004567	substrate binding site [chemical binding]; other site
1423144004568	CoA binding site [chemical binding]; other site
1423144004569	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1423144004570	pyruvate dehydrogenase complex dihydrolipoamide acetyltransferase, long form; Region: PDHac_trf_mito; TIGR01349
1423144004571	E3 interaction surface; other site
1423144004572	lipoyl attachment site [posttranslational modification]; other site
1423144004573	e3 binding domain; Region: E3_binding; pfam02817
1423144004574	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1423144004575	pyruvate dehydrogenase subunit beta; Provisional; Region: PRK11892
1423144004576	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1423144004577	E3 interaction surface; other site
1423144004578	lipoyl attachment site [posttranslational modification]; other site
1423144004579	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1423144004580	alpha subunit interface [polypeptide binding]; other site
1423144004581	TPP binding site [chemical binding]; other site
1423144004582	heterodimer interface [polypeptide binding]; other site
1423144004583	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1423144004584	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
1423144004585	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1423144004586	tetramer interface [polypeptide binding]; other site
1423144004587	TPP-binding site [chemical binding]; other site
1423144004588	heterodimer interface [polypeptide binding]; other site
1423144004589	phosphorylation loop region [posttranslational modification]
1423144004590	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
1423144004591	Septum formation initiator; Region: DivIC; pfam04977
1423144004592	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
1423144004593	Phosphoglycerate kinase; Region: PGK; pfam00162
1423144004594	substrate binding site [chemical binding]; other site
1423144004595	hinge regions; other site
1423144004596	ADP binding site [chemical binding]; other site
1423144004597	catalytic site [active]
1423144004598	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1423144004599	active site
1423144004600	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317
1423144004601	active site
1423144004602	Protein of unknown function (DUF3179); Region: DUF3179; pfam11376
1423144004603	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
1423144004604	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
1423144004605	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
1423144004606	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1423144004607	Peptidase family M23; Region: Peptidase_M23; pfam01551
1423144004608	Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657
1423144004609	dinuclear metal binding motif [ion binding]; other site
1423144004610	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
1423144004611	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1423144004612	catalytic triad [active]
1423144004613	Protein of unknown function; Region: DUF3971; pfam13116
1423144004614	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
1423144004615	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
1423144004616	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
1423144004617	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1423144004618	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1423144004619	putative substrate translocation pore; other site
1423144004620	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
1423144004621	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416
1423144004622	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1423144004623	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1423144004624	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1423144004625	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1423144004626	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
1423144004627	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1423144004628	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
1423144004629	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
1423144004630	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1423144004631	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
1423144004632	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
1423144004633	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1423144004634	substrate binding site [chemical binding]; other site
1423144004635	oxyanion hole (OAH) forming residues; other site
1423144004636	trimer interface [polypeptide binding]; other site
1423144004637	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
1423144004638	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1423144004639	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1423144004640	active site
1423144004641	TPR repeat; Region: TPR_11; pfam13414
1423144004642	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1423144004643	binding surface
1423144004644	TPR motif; other site
1423144004645	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1423144004646	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1423144004647	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1423144004648	Fatty acid desaturase; Region: FA_desaturase; pfam00487
1423144004649	The Delta12 Fatty Acid Desaturase (Delta12-FADS)-like CD includes the integral-membrane enzymes, delta-12 acyl-lipid desaturases, oleate 12-hydroxylases, omega3 and omega6 fatty acid desaturases, and other related proteins, found in a wide range of...; Region: Delta12-FADS-like; cd03507
1423144004650	putative di-iron ligands [ion binding]; other site
1423144004651	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
1423144004652	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
1423144004653	tetrameric interface [polypeptide binding]; other site
1423144004654	NAD binding site [chemical binding]; other site
1423144004655	catalytic residues [active]
1423144004656	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1423144004657	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144004658	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1423144004659	dimerization interface [polypeptide binding]; other site
1423144004660	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623
1423144004661	FOG: CBS domain [General function prediction only]; Region: COG0517
1423144004662	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
1423144004663	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
1423144004664	active site
1423144004665	(T/H)XGH motif; other site
1423144004666	Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057
1423144004667	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1423144004668	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1423144004669	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2354
1423144004670	Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; cl17722
1423144004671	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
1423144004672	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
1423144004673	Walker A/P-loop; other site
1423144004674	ATP binding site [chemical binding]; other site
1423144004675	Q-loop/lid; other site
1423144004676	ABC transporter signature motif; other site
1423144004677	Walker B; other site
1423144004678	D-loop; other site
1423144004679	H-loop/switch region; other site
1423144004680	cobalt ABC transporter, permease protein CbiQ; Region: CbiQ_TIGR; TIGR02454
1423144004681	cobalt transport protein CbiM; Validated; Region: PRK06265
1423144004682	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
1423144004683	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
1423144004684	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
1423144004685	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1423144004686	N-terminal plug; other site
1423144004687	ligand-binding site [chemical binding]; other site
1423144004688	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1423144004689	intersubunit interface [polypeptide binding]; other site
1423144004690	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
1423144004691	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1423144004692	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1423144004693	putative PBP binding regions; other site
1423144004694	ABC-ATPase subunit  interface; other site
1423144004695	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1423144004696	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1423144004697	Walker A/P-loop; other site
1423144004698	ATP binding site [chemical binding]; other site
1423144004699	Q-loop/lid; other site
1423144004700	ABC transporter signature motif; other site
1423144004701	Walker B; other site
1423144004702	D-loop; other site
1423144004703	H-loop/switch region; other site
1423144004704	Adenosylcobinamide amidohydrolase; Region: CbiZ; pfam01955
1423144004705	peptide synthase; Provisional; Region: PRK12467
1423144004706	Predicted integral membrane proteins containing uncharacterized repeats [Function unknown]; Region: COG5563
1423144004707	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1423144004708	active site
1423144004709	DNA binding site [nucleotide binding]
1423144004710	Int/Topo IB signature motif; other site
1423144004711	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1423144004712	non-specific DNA binding site [nucleotide binding]; other site
1423144004713	salt bridge; other site
1423144004714	sequence-specific DNA binding site [nucleotide binding]; other site
1423144004715	Uncharacterized conserved protein [Function unknown]; Region: COG4933
1423144004716	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
1423144004717	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
1423144004718	nudix motif; other site
1423144004719	Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021
1423144004720	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
1423144004721	TPP-binding site [chemical binding]; other site
1423144004722	dimer interface [polypeptide binding]; other site
1423144004723	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1423144004724	PYR/PP interface [polypeptide binding]; other site
1423144004725	dimer interface [polypeptide binding]; other site
1423144004726	TPP binding site [chemical binding]; other site
1423144004727	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1423144004728	Cell division protein ZapA; Region: ZapA; pfam05164
1423144004729	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1423144004730	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1423144004731	Protein of unknown function (DUF1295); Region: DUF1295; cl17837
1423144004732	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
1423144004733	putative GSH binding site [chemical binding]; other site
1423144004734	catalytic residues [active]
1423144004735	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
1423144004736	phosphoribosylformylglycinamidine synthase II; Provisional; Region: PRK01213
1423144004737	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
1423144004738	dimerization interface [polypeptide binding]; other site
1423144004739	ATP binding site [chemical binding]; other site
1423144004740	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
1423144004741	dimerization interface [polypeptide binding]; other site
1423144004742	ATP binding site [chemical binding]; other site
1423144004743	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1423144004744	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144004745	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1423144004746	putative effector binding pocket; other site
1423144004747	dimerization interface [polypeptide binding]; other site
1423144004748	indolepyruvate ferredoxin oxidoreductase; Validated; Region: PRK09193
1423144004749	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1423144004750	dimer interface [polypeptide binding]; other site
1423144004751	PYR/PP interface [polypeptide binding]; other site
1423144004752	TPP binding site [chemical binding]; other site
1423144004753	substrate binding site [chemical binding]; other site
1423144004754	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1423144004755	TPP-binding site [chemical binding]; other site
1423144004756	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
1423144004757	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ACT14924; Region: LPLAT_ACT14924-like; cd07986
1423144004758	putative acyl-acceptor binding pocket; other site
1423144004759	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
1423144004760	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
1423144004761	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
1423144004762	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13254
1423144004763	Glycosyl hydrolase 108; Region: Glyco_hydro_108; pfam05838
1423144004764	Predicted Peptidoglycan domain; Region: PG_binding_3; pfam09374
1423144004765	Protein of unknown function (DUF3154); Region: DUF3154; pfam11351
1423144004766	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
1423144004767	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
1423144004768	enoyl-CoA hydratase; Provisional; Region: PRK08140
1423144004769	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1423144004770	substrate binding site [chemical binding]; other site
1423144004771	oxyanion hole (OAH) forming residues; other site
1423144004772	trimer interface [polypeptide binding]; other site
1423144004773	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
1423144004774	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
1423144004775	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
1423144004776	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
1423144004777	dimer interface [polypeptide binding]; other site
1423144004778	active site
1423144004779	citrylCoA binding site [chemical binding]; other site
1423144004780	NADH binding [chemical binding]; other site
1423144004781	cationic pore residues; other site
1423144004782	oxalacetate/citrate binding site [chemical binding]; other site
1423144004783	coenzyme A binding site [chemical binding]; other site
1423144004784	catalytic triad [active]
1423144004785	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
1423144004786	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1423144004787	active site
1423144004788	HIGH motif; other site
1423144004789	nucleotide binding site [chemical binding]; other site
1423144004790	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
1423144004791	active site
1423144004792	KMSKS motif; other site
1423144004793	Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658
1423144004794	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
1423144004795	Competence protein; Region: Competence; pfam03772
1423144004796	LexA repressor; Validated; Region: PRK00215
1423144004797	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
1423144004798	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1423144004799	Catalytic site [active]
1423144004800	Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303
1423144004801	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1423144004802	dimer interface [polypeptide binding]; other site
1423144004803	putative functional site; other site
1423144004804	putative MPT binding site; other site
1423144004805	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
1423144004806	trimer interface [polypeptide binding]; other site
1423144004807	dimer interface [polypeptide binding]; other site
1423144004808	putative active site [active]
1423144004809	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
1423144004810	active site
1423144004811	ribulose/triose binding site [chemical binding]; other site
1423144004812	phosphate binding site [ion binding]; other site
1423144004813	substrate (anthranilate) binding pocket [chemical binding]; other site
1423144004814	product (indole) binding pocket [chemical binding]; other site
1423144004815	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
1423144004816	ligand binding site [chemical binding]; other site
1423144004817	active site
1423144004818	UGI interface [polypeptide binding]; other site
1423144004819	catalytic site [active]
1423144004820	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
1423144004821	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1423144004822	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1423144004823	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
1423144004824	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
1423144004825	glutamine binding [chemical binding]; other site
1423144004826	catalytic triad [active]
1423144004827	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
1423144004828	NodB motif; other site
1423144004829	putative active site [active]
1423144004830	putative catalytic site [active]
1423144004831	Zn binding site [ion binding]; other site
1423144004832	anthranilate synthase component I; Provisional; Region: PRK13573
1423144004833	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
1423144004834	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
1423144004835	SurA N-terminal domain; Region: SurA_N_3; cl07813
1423144004836	PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145
1423144004837	hypothetical protein; Provisional; Region: PRK07550
1423144004838	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1423144004839	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144004840	homodimer interface [polypeptide binding]; other site
1423144004841	catalytic residue [active]
1423144004842	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1423144004843	active site
1423144004844	LysE type translocator; Region: LysE; cl00565
1423144004845	enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK08159
1423144004846	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
1423144004847	NAD binding site [chemical binding]; other site
1423144004848	homotetramer interface [polypeptide binding]; other site
1423144004849	homodimer interface [polypeptide binding]; other site
1423144004850	substrate binding site [chemical binding]; other site
1423144004851	active site
1423144004852	pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558
1423144004853	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
1423144004854	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
1423144004855	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1423144004856	DNA-binding site [nucleotide binding]; DNA binding site
1423144004857	RNA-binding motif; other site
1423144004858	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
1423144004859	DNA-binding site [nucleotide binding]; DNA binding site
1423144004860	RNA-binding motif; other site
1423144004861	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
1423144004862	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07562
1423144004863	Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471
1423144004864	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
1423144004865	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
1423144004866	active site
1423144004867	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
1423144004868	TSCPD domain; Region: TSCPD; pfam12637
1423144004869	Ammonium Transporter Family; Region: Ammonium_transp; cl03012
1423144004870	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1423144004871	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1423144004872	metal binding site [ion binding]; metal-binding site
1423144004873	active site
1423144004874	I-site; other site
1423144004875	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1423144004876	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1423144004877	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1423144004878	DNA-binding site [nucleotide binding]; DNA binding site
1423144004879	FCD domain; Region: FCD; pfam07729
1423144004880	hypothetical protein; Provisional; Region: PRK05968
1423144004881	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1423144004882	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1423144004883	catalytic residue [active]
1423144004884	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1423144004885	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1423144004886	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144004887	dimer interface [polypeptide binding]; other site
1423144004888	conserved gate region; other site
1423144004889	putative PBP binding loops; other site
1423144004890	ABC-ATPase subunit interface; other site
1423144004891	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1423144004892	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144004893	dimer interface [polypeptide binding]; other site
1423144004894	conserved gate region; other site
1423144004895	putative PBP binding loops; other site
1423144004896	ABC-ATPase subunit interface; other site
1423144004897	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1423144004898	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1423144004899	Walker A/P-loop; other site
1423144004900	ATP binding site [chemical binding]; other site
1423144004901	Q-loop/lid; other site
1423144004902	ABC transporter signature motif; other site
1423144004903	Walker B; other site
1423144004904	D-loop; other site
1423144004905	H-loop/switch region; other site
1423144004906	TOBE domain; Region: TOBE_2; pfam08402
1423144004907	N-acylglucosamine 2-epimerase (GlcNAc 2-epimerase); Region: GlcNAc_2-epim; pfam07221
1423144004908	putative active cleft [active]
1423144004909	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
1423144004910	active site
1423144004911	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1423144004912	cyclase homology domain; Region: CHD; cd07302
1423144004913	nucleotidyl binding site; other site
1423144004914	metal binding site [ion binding]; metal-binding site
1423144004915	dimer interface [polypeptide binding]; other site
1423144004916	Predicted integral membrane protein [Function unknown]; Region: COG5616
1423144004917	TPR repeat; Region: TPR_11; pfam13414
1423144004918	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1423144004919	TPR motif; other site
1423144004920	binding surface
1423144004921	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1423144004922	TPR motif; other site
1423144004923	binding surface
1423144004924	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1423144004925	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1423144004926	putative DNA binding site [nucleotide binding]; other site
1423144004927	dimerization interface [polypeptide binding]; other site
1423144004928	putative Zn2+ binding site [ion binding]; other site
1423144004929	AsnC family; Region: AsnC_trans_reg; pfam01037
1423144004930	methionine gamma-lyase; Provisional; Region: PRK07503
1423144004931	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1423144004932	homodimer interface [polypeptide binding]; other site
1423144004933	substrate-cofactor binding pocket; other site
1423144004934	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144004935	catalytic residue [active]
1423144004936	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1423144004937	TPP-binding site [chemical binding]; other site
1423144004938	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
1423144004939	PYR/PP interface [polypeptide binding]; other site
1423144004940	dimer interface [polypeptide binding]; other site
1423144004941	TPP binding site [chemical binding]; other site
1423144004942	Transketolase, pyrimidine binding domain; Region: Transket_pyr; smart00861
1423144004943	Chemotaxis response regulator containing a CheY-like receiver domain and a methylesterase domain [Cell motility and secretion / Signal transduction mechanisms]; Region: CheB; COG2201
1423144004944	CheB methylesterase; Region: CheB_methylest; pfam01339
1423144004945	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
1423144004946	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
1423144004947	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
1423144004948	PAS domain; Region: PAS_10; pfam13596
1423144004949	PAS fold; Region: PAS; pfam00989
1423144004950	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1423144004951	PAS fold; Region: PAS_3; pfam08447
1423144004952	putative active site [active]
1423144004953	heme pocket [chemical binding]; other site
1423144004954	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1423144004955	Type I periplasmic binding component of active transport systems that are predicted to be involved in 2-nitrobenzoic acid degradation pathway; Region: PBP1_Nba_like; cd06359
1423144004956	putative ligand binding site [chemical binding]; other site
1423144004957	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1423144004958	TM-ABC transporter signature motif; other site
1423144004959	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1423144004960	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1423144004961	TM-ABC transporter signature motif; other site
1423144004962	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1423144004963	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1423144004964	Walker A/P-loop; other site
1423144004965	ATP binding site [chemical binding]; other site
1423144004966	Q-loop/lid; other site
1423144004967	ABC transporter signature motif; other site
1423144004968	Walker B; other site
1423144004969	D-loop; other site
1423144004970	H-loop/switch region; other site
1423144004971	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1423144004972	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1423144004973	Walker A/P-loop; other site
1423144004974	ATP binding site [chemical binding]; other site
1423144004975	Q-loop/lid; other site
1423144004976	ABC transporter signature motif; other site
1423144004977	Walker B; other site
1423144004978	D-loop; other site
1423144004979	H-loop/switch region; other site
1423144004980	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1423144004981	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1423144004982	active site
1423144004983	Trimethylamine:corrinoid methyltransferase [Coenzyme metabolism]; Region: COG5598
1423144004984	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
1423144004985	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
1423144004986	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
1423144004987	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1423144004988	active site
1423144004989	HIGH motif; other site
1423144004990	nucleotide binding site [chemical binding]; other site
1423144004991	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
1423144004992	KMSKS motif; other site
1423144004993	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1423144004994	putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344
1423144004995	Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941
1423144004996	active site
1423144004997	catalytic residues [active]
1423144004998	metal binding site [ion binding]; metal-binding site
1423144004999	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917
1423144005000	Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210
1423144005001	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1423144005002	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
1423144005003	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1423144005004	helix-hairpin-helix signature motif; other site
1423144005005	substrate binding pocket [chemical binding]; other site
1423144005006	active site
1423144005007	Predicted esterase [General function prediction only]; Region: COG0400
1423144005008	putative hydrolase; Provisional; Region: PRK11460
1423144005009	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
1423144005010	pseudouridine synthase; Region: TIGR00093
1423144005011	active site
1423144005012	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
1423144005013	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
1423144005014	active site
1423144005015	ornithine cyclodeaminase; Validated; Region: PRK07589
1423144005016	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
1423144005017	Uncharacterized protein conserved in bacteria containing a pentein-type domain [Function unknown]; Region: COG4874
1423144005018	Amidinotransferase; Region: Amidinotransf; pfam02274
1423144005019	Arginase family; Region: Arginase; cd09989
1423144005020	active site
1423144005021	Mn binding site [ion binding]; other site
1423144005022	oligomer interface [polypeptide binding]; other site
1423144005023	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1423144005024	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1423144005025	AsnC family; Region: AsnC_trans_reg; pfam01037
1423144005026	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
1423144005027	Predicted membrane protein [Function unknown]; Region: COG1238
1423144005028	Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437
1423144005029	HD domain; Region: HD_5; pfam13487
1423144005030	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
1423144005031	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1423144005032	Zn2+ binding site [ion binding]; other site
1423144005033	Mg2+ binding site [ion binding]; other site
1423144005034	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1423144005035	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1423144005036	Walker A/P-loop; other site
1423144005037	ATP binding site [chemical binding]; other site
1423144005038	Q-loop/lid; other site
1423144005039	ABC transporter signature motif; other site
1423144005040	Walker B; other site
1423144005041	D-loop; other site
1423144005042	H-loop/switch region; other site
1423144005043	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1423144005044	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1423144005045	Walker A/P-loop; other site
1423144005046	ATP binding site [chemical binding]; other site
1423144005047	Q-loop/lid; other site
1423144005048	ABC transporter signature motif; other site
1423144005049	Walker B; other site
1423144005050	D-loop; other site
1423144005051	H-loop/switch region; other site
1423144005052	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1423144005053	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
1423144005054	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144005055	putative PBP binding loops; other site
1423144005056	dimer interface [polypeptide binding]; other site
1423144005057	ABC-ATPase subunit interface; other site
1423144005058	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1423144005059	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144005060	dimer interface [polypeptide binding]; other site
1423144005061	conserved gate region; other site
1423144005062	putative PBP binding loops; other site
1423144005063	ABC-ATPase subunit interface; other site
1423144005064	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512
1423144005065	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1423144005066	renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301
1423144005067	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
1423144005068	active site
1423144005069	dimer interface [polypeptide binding]; other site
1423144005070	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
1423144005071	intersubunit interface [polypeptide binding]; other site
1423144005072	active site
1423144005073	Zn2+ binding site [ion binding]; other site
1423144005074	methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720
1423144005075	S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512
1423144005076	Ubiquitin-like proteins; Region: UBQ; cl00155
1423144005077	charged pocket; other site
1423144005078	hydrophobic patch; other site
1423144005079	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
1423144005080	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1423144005081	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1423144005082	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
1423144005083	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1423144005084	catalytic loop [active]
1423144005085	iron binding site [ion binding]; other site
1423144005086	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1423144005087	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
1423144005088	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
1423144005089	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
1423144005090	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
1423144005091	TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666
1423144005092	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
1423144005093	Domain of unknown function (DUF3394); Region: DUF3394; pfam11874
1423144005094	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1423144005095	Ligand Binding Site [chemical binding]; other site
1423144005096	Hydroxyneurosporene synthase (CrtC); Region: CrtC; cl12101
1423144005097	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1423144005098	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1423144005099	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1423144005100	Walker A/P-loop; other site
1423144005101	ATP binding site [chemical binding]; other site
1423144005102	Q-loop/lid; other site
1423144005103	ABC transporter signature motif; other site
1423144005104	Walker B; other site
1423144005105	D-loop; other site
1423144005106	H-loop/switch region; other site
1423144005107	Ion channel; Region: Ion_trans_2; pfam07885
1423144005108	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
1423144005109	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1423144005110	putative active site [active]
1423144005111	catalytic site [active]
1423144005112	Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239
1423144005113	putative active site [active]
1423144005114	catalytic site [active]
1423144005115	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
1423144005116	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
1423144005117	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1423144005118	S-adenosylmethionine binding site [chemical binding]; other site
1423144005119	exopolyphosphatase; Region: exo_poly_only; TIGR03706
1423144005120	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
1423144005121	Virulence factor; Region: Virulence_fact; pfam13769
1423144005122	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cl00246
1423144005123	FAD binding site [chemical binding]; other site
1423144005124	Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410
1423144005125	methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; Validated; Region: PRK07535
1423144005126	substrate binding pocket [chemical binding]; other site
1423144005127	dimer interface [polypeptide binding]; other site
1423144005128	inhibitor binding site; inhibition site
1423144005129	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
1423144005130	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1423144005131	active site
1423144005132	DNA binding site [nucleotide binding]
1423144005133	Int/Topo IB signature motif; other site
1423144005134	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1423144005135	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1423144005136	catalytic residues [active]
1423144005137	catalytic nucleophile [active]
1423144005138	Presynaptic Site I dimer interface [polypeptide binding]; other site
1423144005139	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1423144005140	Synaptic Flat tetramer interface [polypeptide binding]; other site
1423144005141	Synaptic Site I dimer interface [polypeptide binding]; other site
1423144005142	DNA binding site [nucleotide binding]
1423144005143	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1423144005144	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
1423144005145	DNA methylase; Region: N6_N4_Mtase; pfam01555
1423144005146	Predicted transcriptional regulator [Transcription]; Region: COG2932
1423144005147	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1423144005148	non-specific DNA binding site [nucleotide binding]; other site
1423144005149	salt bridge; other site
1423144005150	sequence-specific DNA binding site [nucleotide binding]; other site
1423144005151	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
1423144005152	Catalytic site [active]
1423144005153	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
1423144005154	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1423144005155	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1423144005156	non-specific DNA interactions [nucleotide binding]; other site
1423144005157	DNA binding site [nucleotide binding]
1423144005158	sequence specific DNA binding site [nucleotide binding]; other site
1423144005159	putative cAMP binding site [chemical binding]; other site
1423144005160	This domain directs oriented DNA translocation and forms a winged helix structure; Region: Ftsk_gamma; smart00843
1423144005161	Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073
1423144005162	Protein of unknown function (DUF1064); Region: DUF1064; pfam06356
1423144005163	Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553
1423144005164	Transcription antiterminator [Transcription]; Region: NusG; COG0250
1423144005165	Transcription termination factor nusG; Region: NusG; pfam02357
1423144005166	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1423144005167	Phage Terminase; Region: Terminase_1; pfam03354
1423144005168	Phage-related protein [Function unknown]; Region: COG4695
1423144005169	Phage portal protein; Region: Phage_portal; pfam04860
1423144005170	Clp protease; Region: CLP_protease; pfam00574
1423144005171	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
1423144005172	oligomer interface [polypeptide binding]; other site
1423144005173	active site residues [active]
1423144005174	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
1423144005175	Phage capsid family; Region: Phage_capsid; pfam05065
1423144005176	phage conserved hypothetical protein, phiE125 gp8 family; Region: phage_chp_gp8; TIGR02215
1423144005177	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
1423144005178	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
1423144005179	Bacteriophage protein of unknown function (DUF646); Region: DUF646; cl12124
1423144005180	Protein of unknown function (DUF3168); Region: DUF3168; pfam11367
1423144005181	Protein of unknown function (DUF1353); Region: DUF1353; pfam07087
1423144005182	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1423144005183	Putative peptidoglycan-binding domain-containing protein [Cell envelope biogenesis, outer membrane]; Region: COG3409
1423144005184	TIGR02594 family protein; Region: TIGR02594
1423144005185	Restriction endonuclease; Region: Mrr_cat; pfam04471
1423144005186	Uncharacterized ACR, COG2135; Region: DUF159; pfam02586
1423144005187	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
1423144005188	Peptidase M15; Region: Peptidase_M15_3; cl01194
1423144005189	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
1423144005190	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1423144005191	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1423144005192	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
1423144005193	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
1423144005194	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
1423144005195	trimer interface [polypeptide binding]; other site
1423144005196	active site
1423144005197	UDP-GlcNAc binding site [chemical binding]; other site
1423144005198	lipid binding site [chemical binding]; lipid-binding site
1423144005199	acyl carrier protein; Provisional; Region: acpP; PRK00982
1423144005200	beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150
1423144005201	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1423144005202	dimer interface [polypeptide binding]; other site
1423144005203	active site
1423144005204	Invasion associated locus B (IalB) protein; Region: IalB; pfam06776
1423144005205	Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872
1423144005206	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1423144005207	Walker A motif; other site
1423144005208	ATP binding site [chemical binding]; other site
1423144005209	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1423144005210	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1423144005211	TM-ABC transporter signature motif; other site
1423144005212	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1423144005213	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1423144005214	TM-ABC transporter signature motif; other site
1423144005215	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1423144005216	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1423144005217	Walker A/P-loop; other site
1423144005218	ATP binding site [chemical binding]; other site
1423144005219	Q-loop/lid; other site
1423144005220	ABC transporter signature motif; other site
1423144005221	Walker B; other site
1423144005222	D-loop; other site
1423144005223	H-loop/switch region; other site
1423144005224	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1423144005225	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1423144005226	Walker A/P-loop; other site
1423144005227	ATP binding site [chemical binding]; other site
1423144005228	Q-loop/lid; other site
1423144005229	ABC transporter signature motif; other site
1423144005230	Walker B; other site
1423144005231	D-loop; other site
1423144005232	H-loop/switch region; other site
1423144005233	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1423144005234	Type I periplasmic ligand-binding domain of uncharacterized ABC (Atpase Binding Cassette)-type active transport systems that are predicted to be involved in uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_11; cd06346
1423144005235	putative ligand binding site [chemical binding]; other site
1423144005236	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
1423144005237	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
1423144005238	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1423144005239	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
1423144005240	conserved cys residue [active]
1423144005241	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1423144005242	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1423144005243	Class-II DAHP synthetase family; Region: DAHP_synth_2; pfam01474
1423144005244	PAS domain; Region: PAS_5; pfam07310
1423144005245	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5388
1423144005246	hypothetical protein; Provisional; Region: PRK11820
1423144005247	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
1423144005248	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
1423144005249	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
1423144005250	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
1423144005251	catalytic site [active]
1423144005252	G-X2-G-X-G-K; other site
1423144005253	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
1423144005254	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
1423144005255	trimer interface [polypeptide binding]; other site
1423144005256	putative metal binding site [ion binding]; other site
1423144005257	Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626
1423144005258	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1423144005259	homodimer interface [polypeptide binding]; other site
1423144005260	substrate-cofactor binding pocket; other site
1423144005261	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144005262	catalytic residue [active]
1423144005263	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1423144005264	dimer interface [polypeptide binding]; other site
1423144005265	phosphorylation site [posttranslational modification]
1423144005266	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1423144005267	ATP binding site [chemical binding]; other site
1423144005268	Mg2+ binding site [ion binding]; other site
1423144005269	G-X-G motif; other site
1423144005270	PBP superfamily domain; Region: PBP_like_2; pfam12849
1423144005271	Phosphate ATP-binding cassette transporter; Region: DUF3708; pfam12501
1423144005272	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
1423144005273	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144005274	dimer interface [polypeptide binding]; other site
1423144005275	conserved gate region; other site
1423144005276	putative PBP binding loops; other site
1423144005277	ABC-ATPase subunit interface; other site
1423144005278	Domain of unknown function (DUF3333); Region: DUF3333; pfam11812
1423144005279	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstA; COG0581
1423144005280	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144005281	dimer interface [polypeptide binding]; other site
1423144005282	conserved gate region; other site
1423144005283	putative PBP binding loops; other site
1423144005284	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1423144005285	ABC-ATPase subunit interface; other site
1423144005286	phosphate transporter ATP-binding protein; Provisional; Region: PRK14235
1423144005287	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
1423144005288	Walker A/P-loop; other site
1423144005289	ATP binding site [chemical binding]; other site
1423144005290	Q-loop/lid; other site
1423144005291	ABC transporter signature motif; other site
1423144005292	Walker B; other site
1423144005293	D-loop; other site
1423144005294	H-loop/switch region; other site
1423144005295	phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135
1423144005296	PhoU domain; Region: PhoU; pfam01895
1423144005297	PhoU domain; Region: PhoU; pfam01895
1423144005298	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
1423144005299	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144005300	active site
1423144005301	phosphorylation site [posttranslational modification]
1423144005302	intermolecular recognition site; other site
1423144005303	dimerization interface [polypeptide binding]; other site
1423144005304	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1423144005305	DNA binding site [nucleotide binding]
1423144005306	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144005307	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1423144005308	The C-terminal substrate binding domain of LysR-type transcriptional regulators GcdR-like, contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_like; cd08481
1423144005309	dimerization interface [polypeptide binding]; other site
1423144005310	substrate binding pocket [chemical binding]; other site
1423144005311	Glutaryl-CoA dehydrogenase; Region: GCD; cd01151
1423144005312	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1423144005313	FAD binding site [chemical binding]; other site
1423144005314	substrate binding pocket [chemical binding]; other site
1423144005315	catalytic base [active]
1423144005316	hypothetical protein; Provisional; Region: PRK06194
1423144005317	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1423144005318	NAD(P) binding site [chemical binding]; other site
1423144005319	active site
1423144005320	Acyl-CoA thioesterase [Lipid metabolism]; Region: TesB; COG1946
1423144005321	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
1423144005322	active site
1423144005323	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
1423144005324	catalytic triad [active]
1423144005325	dimer interface [polypeptide binding]; other site
1423144005326	Beta-lactamase; Region: Beta-lactamase; pfam00144
1423144005327	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1423144005328	enoyl-CoA hydratase; Provisional; Region: PRK05870
1423144005329	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1423144005330	substrate binding site [chemical binding]; other site
1423144005331	oxyanion hole (OAH) forming residues; other site
1423144005332	trimer interface [polypeptide binding]; other site
1423144005333	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1423144005334	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1423144005335	Bacterial transcriptional regulator; Region: IclR; pfam01614
1423144005336	Acyl-CoA dehydrogenase (ACAD) 10 and 11, N-terminal domain, and similar proteins. This subfamily is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: ACAD10_11_like; cd05154
1423144005337	Phosphotransferase enzyme family; Region: APH; pfam01636
1423144005338	putative active site [active]
1423144005339	putative substrate binding site [chemical binding]; other site
1423144005340	ATP binding site [chemical binding]; other site
1423144005341	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
1423144005342	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1423144005343	FMN binding site [chemical binding]; other site
1423144005344	substrate binding site [chemical binding]; other site
1423144005345	putative catalytic residue [active]
1423144005346	Quinone oxidoreductase (QOR); Region: QOR1; cd08241
1423144005347	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1423144005348	NAD(P) binding site [chemical binding]; other site
1423144005349	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
1423144005350	Dehydroquinase class II; Region: DHquinase_II; pfam01220
1423144005351	active site
1423144005352	trimer interface [polypeptide binding]; other site
1423144005353	dimer interface [polypeptide binding]; other site
1423144005354	Autoinducer binding domain; Region: Autoind_bind; pfam03472
1423144005355	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1423144005356	DNA binding residues [nucleotide binding]
1423144005357	dimerization interface [polypeptide binding]; other site
1423144005358	elongation factor Ts; Provisional; Region: tsf; PRK09377
1423144005359	UBA/TS-N domain; Region: UBA; pfam00627
1423144005360	Elongation factor TS; Region: EF_TS; pfam00889
1423144005361	Elongation factor TS; Region: EF_TS; pfam00889
1423144005362	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
1423144005363	rRNA interaction site [nucleotide binding]; other site
1423144005364	S8 interaction site; other site
1423144005365	putative laminin-1 binding site; other site
1423144005366	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
1423144005367	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1423144005368	putative acyl-acceptor binding pocket; other site
1423144005369	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; cl17496
1423144005370	Protein of unknown function (DUF3553); Region: DUF3553; pfam12073
1423144005371	Uncharacterized protein conserved in bacteria (DUF2328); Region: DUF2328; pfam10090
1423144005372	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
1423144005373	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
1423144005374	putative catalytic cysteine [active]
1423144005375	gamma-glutamyl kinase; Provisional; Region: PRK05429
1423144005376	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
1423144005377	nucleotide binding site [chemical binding]; other site
1423144005378	homotetrameric interface [polypeptide binding]; other site
1423144005379	putative phosphate binding site [ion binding]; other site
1423144005380	putative allosteric binding site; other site
1423144005381	PUA domain; Region: PUA; pfam01472
1423144005382	GTPase CgtA; Reviewed; Region: obgE; PRK12299
1423144005383	GTP1/OBG; Region: GTP1_OBG; pfam01018
1423144005384	Obg GTPase; Region: Obg; cd01898
1423144005385	G1 box; other site
1423144005386	GTP/Mg2+ binding site [chemical binding]; other site
1423144005387	Switch I region; other site
1423144005388	G2 box; other site
1423144005389	G3 box; other site
1423144005390	Switch II region; other site
1423144005391	G4 box; other site
1423144005392	G5 box; other site
1423144005393	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1423144005394	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1423144005395	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
1423144005396	Uncharacterized conserved protein [Function unknown]; Region: COG3743
1423144005397	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
1423144005398	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
1423144005399	Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; pfam09832
1423144005400	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1423144005401	binding surface
1423144005402	Tetratricopeptide repeat; Region: TPR_16; pfam13432
1423144005403	TPR motif; other site
1423144005404	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1423144005405	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
1423144005406	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1423144005407	catalytic residue [active]
1423144005408	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223
1423144005409	Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458
1423144005410	Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396
1423144005411	ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217
1423144005412	Walker A/P-loop; other site
1423144005413	ATP binding site [chemical binding]; other site
1423144005414	Q-loop/lid; other site
1423144005415	ABC transporter signature motif; other site
1423144005416	Walker B; other site
1423144005417	D-loop; other site
1423144005418	H-loop/switch region; other site
1423144005419	Putative heavy-metal-binding; Region: YbjQ_1; cl00426
1423144005420	cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814
1423144005421	putative ABC transporter; Region: ycf24; CHL00085
1423144005422	Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104
1423144005423	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
1423144005424	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1423144005425	catalytic residue [active]
1423144005426	Transcriptional regulator; Region: Rrf2; cl17282
1423144005427	Rrf2 family protein; Region: rrf2_super; TIGR00738
1423144005428	Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2945
1423144005429	HD domain; Region: HD_3; pfam13023
1423144005430	HD domain; Region: HD_3; pfam13023
1423144005431	Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076
1423144005432	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
1423144005433	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
1423144005434	G1 box; other site
1423144005435	putative GEF interaction site [polypeptide binding]; other site
1423144005436	GTP/Mg2+ binding site [chemical binding]; other site
1423144005437	Switch I region; other site
1423144005438	G2 box; other site
1423144005439	G3 box; other site
1423144005440	Switch II region; other site
1423144005441	G4 box; other site
1423144005442	G5 box; other site
1423144005443	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
1423144005444	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
1423144005445	Uncharacterized conserved protein [Function unknown]; Region: COG5470
1423144005446	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
1423144005447	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
1423144005448	motif 1; other site
1423144005449	active site
1423144005450	motif 2; other site
1423144005451	motif 3; other site
1423144005452	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
1423144005453	DHHA1 domain; Region: DHHA1; pfam02272
1423144005454	recombinase A; Provisional; Region: recA; PRK09354
1423144005455	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
1423144005456	hexamer interface [polypeptide binding]; other site
1423144005457	Walker A motif; other site
1423144005458	ATP binding site [chemical binding]; other site
1423144005459	Walker B motif; other site
1423144005460	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1423144005461	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1423144005462	dimer interface [polypeptide binding]; other site
1423144005463	phosphorylation site [posttranslational modification]
1423144005464	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1423144005465	ATP binding site [chemical binding]; other site
1423144005466	Mg2+ binding site [ion binding]; other site
1423144005467	G-X-G motif; other site
1423144005468	Response regulator receiver domain; Region: Response_reg; pfam00072
1423144005469	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144005470	active site
1423144005471	phosphorylation site [posttranslational modification]
1423144005472	intermolecular recognition site; other site
1423144005473	dimerization interface [polypeptide binding]; other site
1423144005474	tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144
1423144005475	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1423144005476	S-adenosylmethionine binding site [chemical binding]; other site
1423144005477	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
1423144005478	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1423144005479	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
1423144005480	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
1423144005481	active site
1423144005482	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1423144005483	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1423144005484	Uncharacterized metal-binding protein [General function prediction only]; Region: COG3894
1423144005485	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1423144005486	catalytic loop [active]
1423144005487	iron binding site [ion binding]; other site
1423144005488	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1423144005489	active site
1423144005490	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
1423144005491	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
1423144005492	putative active site [active]
1423144005493	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
1423144005494	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
1423144005495	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
1423144005496	Usg-like family; Region: Usg; pfam06233
1423144005497	DNA gyrase subunit A; Validated; Region: PRK05560
1423144005498	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
1423144005499	CAP-like domain; other site
1423144005500	active site
1423144005501	primary dimer interface [polypeptide binding]; other site
1423144005502	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1423144005503	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1423144005504	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1423144005505	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1423144005506	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
1423144005507	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
1423144005508	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
1423144005509	active site
1423144005510	Zn binding site [ion binding]; other site
1423144005511	Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852
1423144005512	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
1423144005513	rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: LasT; COG0565
1423144005514	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
1423144005515	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1423144005516	thiamine phosphate binding site [chemical binding]; other site
1423144005517	active site
1423144005518	pyrophosphate binding site [ion binding]; other site
1423144005519	HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795
1423144005520	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
1423144005521	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1423144005522	YeiC-like sugar kinase.  Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941
1423144005523	substrate binding site [chemical binding]; other site
1423144005524	ATP binding site [chemical binding]; other site
1423144005525	Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227
1423144005526	Uncharacterized conserved protein [Function unknown]; Region: COG2928
1423144005527	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
1423144005528	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
1423144005529	active site
1423144005530	nucleophile elbow; other site
1423144005531	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1423144005532	3-hydroxybutyrate dehydrogenase; Region: PHB_DH; TIGR01963
1423144005533	NAD(P) binding site [chemical binding]; other site
1423144005534	active site
1423144005535	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
1423144005536	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1423144005537	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1423144005538	dimerization interface [polypeptide binding]; other site
1423144005539	putative DNA binding site [nucleotide binding]; other site
1423144005540	putative Zn2+ binding site [ion binding]; other site
1423144005541	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1423144005542	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1423144005543	active site
1423144005544	Low molecular weight phosphatase family; Region: LMWPc; cd00115
1423144005545	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
1423144005546	active site
1423144005547	Glycerol uptake facilitator and related permeases (Major Intrinsic Protein Family) [Carbohydrate transport and metabolism]; Region: GlpF; COG0580
1423144005548	amphipathic channel; other site
1423144005549	Asn-Pro-Ala signature motifs; other site
1423144005550	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1423144005551	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1423144005552	non-specific DNA binding site [nucleotide binding]; other site
1423144005553	salt bridge; other site
1423144005554	sequence-specific DNA binding site [nucleotide binding]; other site
1423144005555	Cupin domain; Region: Cupin_2; pfam07883
1423144005556	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1423144005557	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1423144005558	acyl-activating enzyme (AAE) consensus motif; other site
1423144005559	AMP binding site [chemical binding]; other site
1423144005560	active site
1423144005561	CoA binding site [chemical binding]; other site
1423144005562	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
1423144005563	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
1423144005564	catalytic residues [active]
1423144005565	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1423144005566	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
1423144005567	putative substrate translocation pore; other site
1423144005568	Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197
1423144005569	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
1423144005570	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1423144005571	ATP binding site [chemical binding]; other site
1423144005572	putative Mg++ binding site [ion binding]; other site
1423144005573	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1423144005574	nucleotide binding region [chemical binding]; other site
1423144005575	ATP-binding site [chemical binding]; other site
1423144005576	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
1423144005577	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
1423144005578	dimer interface [polypeptide binding]; other site
1423144005579	active site
1423144005580	aspartate-rich active site metal binding site; other site
1423144005581	allosteric magnesium binding site [ion binding]; other site
1423144005582	Schiff base residues; other site
1423144005583	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cl01109
1423144005584	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1423144005585	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1423144005586	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1423144005587	Protein related to penicillin acylase [General function prediction only]; Region: COG2366
1423144005588	The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid.  N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467
1423144005589	Penicillin G acylase (PGA) belongs to a family of beta-lactam acylases that includes cephalosporin acylase (CA) and aculeacin A acylase. PGA and CA are crucial for the production of backbone chemicals like 6-aminopenicillanic acid and...; Region: Ntn_PGA_like; cd03747
1423144005590	active site
1423144005591	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
1423144005592	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
1423144005593	HflX GTPase family; Region: HflX; cd01878
1423144005594	G1 box; other site
1423144005595	GTP/Mg2+ binding site [chemical binding]; other site
1423144005596	Switch I region; other site
1423144005597	G2 box; other site
1423144005598	G3 box; other site
1423144005599	Switch II region; other site
1423144005600	G4 box; other site
1423144005601	G5 box; other site
1423144005602	bacterial Hfq-like; Region: Hfq; cd01716
1423144005603	hexamer interface [polypeptide binding]; other site
1423144005604	Sm1 motif; other site
1423144005605	RNA binding site [nucleotide binding]; other site
1423144005606	Sm2 motif; other site
1423144005607	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
1423144005608	Cation transport protein; Region: TrkH; cl17365
1423144005609	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
1423144005610	TrkA-N domain; Region: TrkA_N; pfam02254
1423144005611	TrkA-C domain; Region: TrkA_C; pfam02080
1423144005612	TrkA-N domain; Region: TrkA_N; pfam02254
1423144005613	TrkA-C domain; Region: TrkA_C; pfam02080
1423144005614	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1423144005615	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144005616	active site
1423144005617	phosphorylation site [posttranslational modification]
1423144005618	intermolecular recognition site; other site
1423144005619	dimerization interface [polypeptide binding]; other site
1423144005620	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1423144005621	Walker A motif; other site
1423144005622	ATP binding site [chemical binding]; other site
1423144005623	Walker B motif; other site
1423144005624	arginine finger; other site
1423144005625	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1423144005626	Signal transduction histidine kinase involved in nitrogen fixation and metabolism regulation [Signal transduction mechanisms]; Region: NtrY; COG5000
1423144005627	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1423144005628	dimerization interface [polypeptide binding]; other site
1423144005629	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1423144005630	putative active site [active]
1423144005631	heme pocket [chemical binding]; other site
1423144005632	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1423144005633	dimer interface [polypeptide binding]; other site
1423144005634	phosphorylation site [posttranslational modification]
1423144005635	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1423144005636	ATP binding site [chemical binding]; other site
1423144005637	Mg2+ binding site [ion binding]; other site
1423144005638	G-X-G motif; other site
1423144005639	nitrogen regulation protein NR(I); Region: ntrC; TIGR01818
1423144005640	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144005641	active site
1423144005642	phosphorylation site [posttranslational modification]
1423144005643	intermolecular recognition site; other site
1423144005644	dimerization interface [polypeptide binding]; other site
1423144005645	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1423144005646	Walker A motif; other site
1423144005647	ATP binding site [chemical binding]; other site
1423144005648	Walker B motif; other site
1423144005649	arginine finger; other site
1423144005650	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
1423144005651	Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852
1423144005652	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1423144005653	putative active site [active]
1423144005654	heme pocket [chemical binding]; other site
1423144005655	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1423144005656	dimer interface [polypeptide binding]; other site
1423144005657	phosphorylation site [posttranslational modification]
1423144005658	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1423144005659	ATP binding site [chemical binding]; other site
1423144005660	G-X-G motif; other site
1423144005661	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
1423144005662	Dihydrouridine synthase (Dus); Region: Dus; pfam01207
1423144005663	FMN binding site [chemical binding]; other site
1423144005664	active site
1423144005665	catalytic residues [active]
1423144005666	substrate binding site [chemical binding]; other site
1423144005667	bifunctional 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase/2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase protein; Provisional; Region: ispDF; PRK09382
1423144005668	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
1423144005669	substrate binding site; other site
1423144005670	dimer interface; other site
1423144005671	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
1423144005672	homotrimer interaction site [polypeptide binding]; other site
1423144005673	zinc binding site [ion binding]; other site
1423144005674	CDP-binding sites; other site
1423144005675	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
1423144005676	tetramer interfaces [polypeptide binding]; other site
1423144005677	binuclear metal-binding site [ion binding]; other site
1423144005678	Competence-damaged protein; Region: CinA; pfam02464
1423144005679	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
1423144005680	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
1423144005681	putative coenzyme Q binding site [chemical binding]; other site
1423144005682	Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065
1423144005683	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1423144005684	active site
1423144005685	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1423144005686	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like3; cd05668
1423144005687	metal binding site [ion binding]; metal-binding site
1423144005688	putative dimer interface [polypeptide binding]; other site
1423144005689	lipoyl synthase; Provisional; Region: PRK05481
1423144005690	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1423144005691	FeS/SAM binding site; other site
1423144005692	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
1423144005693	catalytic triad [active]
1423144005694	dimer interface [polypeptide binding]; other site
1423144005695	Trimethylamine methyltransferase (MTTB); Region: MTTB; pfam06253
1423144005696	GMP synthase; Reviewed; Region: guaA; PRK00074
1423144005697	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
1423144005698	AMP/PPi binding site [chemical binding]; other site
1423144005699	candidate oxyanion hole; other site
1423144005700	catalytic triad [active]
1423144005701	potential glutamine specificity residues [chemical binding]; other site
1423144005702	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
1423144005703	ATP Binding subdomain [chemical binding]; other site
1423144005704	Ligand Binding sites [chemical binding]; other site
1423144005705	Dimerization subdomain; other site
1423144005706	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1423144005707	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
1423144005708	Homoserine O-succinyltransferase; Region: HTS; pfam04204
1423144005709	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
1423144005710	proposed active site lysine [active]
1423144005711	conserved cys residue [active]
1423144005712	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
1423144005713	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
1423144005714	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1423144005715	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1423144005716	WHG domain; Region: WHG; pfam13305
1423144005717	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
1423144005718	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
1423144005719	23S rRNA interface [nucleotide binding]; other site
1423144005720	L3 interface [polypeptide binding]; other site
1423144005721	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1423144005722	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1423144005723	DNA-binding site [nucleotide binding]; DNA binding site
1423144005724	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1423144005725	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144005726	homodimer interface [polypeptide binding]; other site
1423144005727	catalytic residue [active]
1423144005728	Domain of unknown function (DUF1127); Region: DUF1127; pfam06568
1423144005729	S-adenosylmethionine decarboxylase proenzyme, Bacillus form; Region: SAM_DCase_Bsu; TIGR03330
1423144005730	spermidine synthase; Provisional; Region: PRK00811
1423144005731	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1423144005732	S-adenosylmethionine binding site [chemical binding]; other site
1423144005733	Phosphatidylserine decarboxylase; Region: PS_Dcarbxylase; cl03656
1423144005734	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1423144005735	CoenzymeA binding site [chemical binding]; other site
1423144005736	subunit interaction site [polypeptide binding]; other site
1423144005737	PHB binding site; other site
1423144005738	enoyl-CoA hydratase; Validated; Region: PRK08139
1423144005739	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1423144005740	substrate binding site [chemical binding]; other site
1423144005741	oxyanion hole (OAH) forming residues; other site
1423144005742	trimer interface [polypeptide binding]; other site
1423144005743	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
1423144005744	Glucose inhibited division protein A; Region: GIDA; pfam01134
1423144005745	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1423144005746	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1423144005747	S-adenosylmethionine binding site [chemical binding]; other site
1423144005748	glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710
1423144005749	active site
1423144005750	KMSKS motif; other site
1423144005751	phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051
1423144005752	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
1423144005753	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
1423144005754	trimerization site [polypeptide binding]; other site
1423144005755	active site
1423144005756	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
1423144005757	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
1423144005758	generic binding surface II; other site
1423144005759	ssDNA binding site; other site
1423144005760	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1423144005761	ATP binding site [chemical binding]; other site
1423144005762	putative Mg++ binding site [ion binding]; other site
1423144005763	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1423144005764	nucleotide binding region [chemical binding]; other site
1423144005765	ATP-binding site [chemical binding]; other site
1423144005766	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
1423144005767	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
1423144005768	nucleotide binding pocket [chemical binding]; other site
1423144005769	K-X-D-G motif; other site
1423144005770	catalytic site [active]
1423144005771	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
1423144005772	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
1423144005773	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
1423144005774	Dimer interface [polypeptide binding]; other site
1423144005775	BRCT sequence motif; other site
1423144005776	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1423144005777	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144005778	active site
1423144005779	phosphorylation site [posttranslational modification]
1423144005780	intermolecular recognition site; other site
1423144005781	dimerization interface [polypeptide binding]; other site
1423144005782	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1423144005783	DNA binding site [nucleotide binding]
1423144005784	Protein of unknown function (DUF1153); Region: DUF1153; pfam06627
1423144005785	Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482
1423144005786	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
1423144005787	Ligand Binding Site [chemical binding]; other site
1423144005788	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
1423144005789	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
1423144005790	Protein of unknown function (DUF1009); Region: DUF1009; pfam06230
1423144005791	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
1423144005792	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
1423144005793	active site
1423144005794	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
1423144005795	Outer membrane protein (OmpH-like); Region: OmpH; pfam03938
1423144005796	outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303
1423144005797	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1423144005798	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1423144005799	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1423144005800	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
1423144005801	Surface antigen; Region: Bac_surface_Ag; pfam01103
1423144005802	RIP metalloprotease RseP; Region: TIGR00054
1423144005803	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1423144005804	active site
1423144005805	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
1423144005806	protein binding site [polypeptide binding]; other site
1423144005807	putative substrate binding region [chemical binding]; other site
1423144005808	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
1423144005809	protein binding site [polypeptide binding]; other site
1423144005810	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
1423144005811	putative substrate binding region [chemical binding]; other site
1423144005812	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
1423144005813	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
1423144005814	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
1423144005815	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
1423144005816	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
1423144005817	Cytidylyltransferase family; Region: CTP_transf_1; pfam01148
1423144005818	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
1423144005819	Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255
1423144005820	catalytic residue [active]
1423144005821	putative FPP diphosphate  binding site; other site
1423144005822	putative FPP binding hydrophobic cleft; other site
1423144005823	dimer interface [polypeptide binding]; other site
1423144005824	putative IPP diphosphate binding site; other site
1423144005825	ribosome recycling factor; Reviewed; Region: frr; PRK00083
1423144005826	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
1423144005827	hinge region; other site
1423144005828	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
1423144005829	putative nucleotide binding site [chemical binding]; other site
1423144005830	uridine monophosphate binding site [chemical binding]; other site
1423144005831	homohexameric interface [polypeptide binding]; other site
1423144005832	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
1423144005833	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cd02019
1423144005834	active site
1423144005835	Helix-turn-helix domain; Region: HTH_18; pfam12833
1423144005836	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1423144005837	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1423144005838	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
1423144005839	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1423144005840	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144005841	dimer interface [polypeptide binding]; other site
1423144005842	conserved gate region; other site
1423144005843	putative PBP binding loops; other site
1423144005844	ABC-ATPase subunit interface; other site
1423144005845	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1423144005846	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144005847	conserved gate region; other site
1423144005848	glutathione transporter ATP-binding protein; Provisional; Region: PRK10261
1423144005849	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1423144005850	Walker A/P-loop; other site
1423144005851	ATP binding site [chemical binding]; other site
1423144005852	Q-loop/lid; other site
1423144005853	ABC transporter signature motif; other site
1423144005854	Walker B; other site
1423144005855	D-loop; other site
1423144005856	H-loop/switch region; other site
1423144005857	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1423144005858	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1423144005859	Walker A/P-loop; other site
1423144005860	ATP binding site [chemical binding]; other site
1423144005861	Q-loop/lid; other site
1423144005862	ABC transporter signature motif; other site
1423144005863	Walker B; other site
1423144005864	D-loop; other site
1423144005865	H-loop/switch region; other site
1423144005866	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1423144005867	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1423144005868	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1423144005869	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1423144005870	catalytic residue [active]
1423144005871	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1423144005872	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1423144005873	dimer interface [polypeptide binding]; other site
1423144005874	ssDNA binding site [nucleotide binding]; other site
1423144005875	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1423144005876	Nitrate and nitrite sensing; Region: NIT; pfam08376
1423144005877	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1423144005878	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1423144005879	dimer interface [polypeptide binding]; other site
1423144005880	putative CheW interface [polypeptide binding]; other site
1423144005881	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
1423144005882	active site
1423144005883	dimer interface [polypeptide binding]; other site
1423144005884	metal binding site [ion binding]; metal-binding site
1423144005885	shikimate kinase; Provisional; Region: PRK13946
1423144005886	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
1423144005887	ADP binding site [chemical binding]; other site
1423144005888	magnesium binding site [ion binding]; other site
1423144005889	putative shikimate binding site; other site
1423144005890	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
1423144005891	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1423144005892	active site
1423144005893	DNA binding site [nucleotide binding]
1423144005894	Int/Topo IB signature motif; other site
1423144005895	Putative Mg2+ and Co2+ transporter CorB [Inorganic ion transport and metabolism]; Region: CorB; COG4536
1423144005896	Domain of unknown function DUF21; Region: DUF21; pfam01595
1423144005897	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1423144005898	Transporter associated domain; Region: CorC_HlyC; smart01091
1423144005899	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1423144005900	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1423144005901	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
1423144005902	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
1423144005903	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1423144005904	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
1423144005905	metal-binding site
1423144005906	Hint domain; Region: Hint_2; pfam13403
1423144005907	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
1423144005908	N- and C-terminal domain interface [polypeptide binding]; other site
1423144005909	D-xylulose kinase; Region: XylB; TIGR01312
1423144005910	active site
1423144005911	MgATP binding site [chemical binding]; other site
1423144005912	catalytic site [active]
1423144005913	metal binding site [ion binding]; metal-binding site
1423144005914	xylulose binding site [chemical binding]; other site
1423144005915	homodimer interface [polypeptide binding]; other site
1423144005916	xylose isomerase; Provisional; Region: PRK05474
1423144005917	xylose isomerase; Region: xylose_isom_A; TIGR02630
1423144005918	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1423144005919	DNA binding site [nucleotide binding]
1423144005920	domain linker motif; other site
1423144005921	Periplasmic sugar-binding domain of uncharacterized transport systems; Region: PBP1_uncharacterized_sugar_binding; cd06307
1423144005922	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1423144005923	putative ligand binding site [chemical binding]; other site
1423144005924	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
1423144005925	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
1423144005926	Protein of unknown function (DUF3772); Region: DUF3772; pfam12607
1423144005927	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: COG3264
1423144005928	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1423144005929	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
1423144005930	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
1423144005931	dimer interface [polypeptide binding]; other site
1423144005932	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144005933	catalytic residue [active]
1423144005934	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1423144005935	putative active site pocket [active]
1423144005936	dimerization interface [polypeptide binding]; other site
1423144005937	putative catalytic residue [active]
1423144005938	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
1423144005939	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
1423144005940	dimer interface [polypeptide binding]; other site
1423144005941	active site
1423144005942	ADP-ribose binding site [chemical binding]; other site
1423144005943	nudix motif; other site
1423144005944	metal binding site [ion binding]; metal-binding site
1423144005945	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
1423144005946	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1423144005947	S-adenosylmethionine binding site [chemical binding]; other site
1423144005948	Deoxyribodipyrimidine photolyase [DNA replication, recombination, and repair]; Region: PhrB; COG0415
1423144005949	DNA photolyase; Region: DNA_photolyase; pfam00875
1423144005950	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
1423144005951	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1423144005952	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1423144005953	catalytic residue [active]
1423144005954	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
1423144005955	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1423144005956	BCCT family transporter; Region: BCCT; pfam02028
1423144005957	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
1423144005958	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
1423144005959	NADP binding site [chemical binding]; other site
1423144005960	dimer interface [polypeptide binding]; other site
1423144005961	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1423144005962	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1423144005963	DNA-binding site [nucleotide binding]; DNA binding site
1423144005964	FCD domain; Region: FCD; pfam07729
1423144005965	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
1423144005966	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
1423144005967	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1423144005968	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1423144005969	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1423144005970	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1423144005971	active site
1423144005972	Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892
1423144005973	Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141
1423144005974	2-polyprenyl-6-methoxyphenol hydroxylase and related FAD-dependent oxidoreductases [Coenzyme metabolism / Energy production and conversion]; Region: UbiH; COG0654
1423144005975	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
1423144005976	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1423144005977	acyl-activating enzyme (AAE) consensus motif; other site
1423144005978	AMP binding site [chemical binding]; other site
1423144005979	active site
1423144005980	CoA binding site [chemical binding]; other site
1423144005981	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1423144005982	Cytochrome P450; Region: p450; cl12078
1423144005983	D-alanine:D-alanyl carrier protein ligase (DltA); Region: DltA; cd05945
1423144005984	D-alanine--poly(phosphoribitol) ligase subunit 1; Provisional; Region: PRK04813
1423144005985	acyl-activating enzyme (AAE) consensus motif; other site
1423144005986	AMP binding site [chemical binding]; other site
1423144005987	Phosphopantetheine attachment site; Region: PP-binding; cl09936
1423144005988	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1423144005989	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1423144005990	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_6; cd05922
1423144005991	acyl-activating enzyme (AAE) consensus motif; other site
1423144005992	putative AMP binding site [chemical binding]; other site
1423144005993	putative active site [active]
1423144005994	acyl-activating enzyme (AAE) consensus motif; other site
1423144005995	putative CoA binding site [chemical binding]; other site
1423144005996	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
1423144005997	active site
1423144005998	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
1423144005999	active site
1423144006000	pyridoxal-dependent decarboxylase, exosortase A system-associated; Region: dCO2ase_PEP1; TIGR03099
1423144006001	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Btrk Decarboxylase; Region: PLPDE_III_Btrk_like; cd06839
1423144006002	dimer interface [polypeptide binding]; other site
1423144006003	active site
1423144006004	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1423144006005	catalytic residues [active]
1423144006006	substrate binding site [chemical binding]; other site
1423144006007	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1423144006008	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1423144006009	active site
1423144006010	3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal; Region: ACP_syn_III_C; pfam08541
1423144006011	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1423144006012	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1423144006013	3-Oxoacyl-[acyl-carrier-protein (ACP)] synthase III C terminal; Region: ACP_syn_III_C; cl17241
1423144006014	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1423144006015	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1423144006016	FtsX-like permease family; Region: FtsX; pfam02687
1423144006017	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1423144006018	FtsX-like permease family; Region: FtsX; pfam02687
1423144006019	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
1423144006020	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1423144006021	Walker A/P-loop; other site
1423144006022	ATP binding site [chemical binding]; other site
1423144006023	Q-loop/lid; other site
1423144006024	ABC transporter signature motif; other site
1423144006025	Walker B; other site
1423144006026	D-loop; other site
1423144006027	H-loop/switch region; other site
1423144006028	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1423144006029	HlyD family secretion protein; Region: HlyD_3; pfam13437
1423144006030	SnoaL-like domain; Region: SnoaL_2; pfam12680
1423144006031	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
1423144006032	Chromate transporter; Region: Chromate_transp; pfam02417
1423144006033	Stringent starvation protein B; Region: SspB; pfam04386
1423144006034	fumarate hydratase; Reviewed; Region: fumC; PRK00485
1423144006035	Class II fumarases; Region: Fumarase_classII; cd01362
1423144006036	active site
1423144006037	tetramer interface [polypeptide binding]; other site
1423144006038	Domain of unknown function (DUF4169); Region: DUF4169; pfam13770
1423144006039	Ribbon-helix-helix domain; Region: RHH_4; pfam13467
1423144006040	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
1423144006041	Cytochrome P450; Region: p450; cl12078
1423144006042	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1423144006043	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
1423144006044	SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain.  SirA (also known as UvrY,  and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291
1423144006045	CPxP  motif; other site
1423144006046	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
1423144006047	Ribonuclease E/G family; Region: RNase_E_G; pfam10150
1423144006048	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
1423144006049	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144006050	active site
1423144006051	phosphorylation site [posttranslational modification]
1423144006052	intermolecular recognition site; other site
1423144006053	dimerization interface [polypeptide binding]; other site
1423144006054	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1423144006055	Walker A motif; other site
1423144006056	ATP binding site [chemical binding]; other site
1423144006057	Walker B motif; other site
1423144006058	arginine finger; other site
1423144006059	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
1423144006060	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
1423144006061	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1423144006062	dimer interface [polypeptide binding]; other site
1423144006063	phosphorylation site [posttranslational modification]
1423144006064	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1423144006065	ATP binding site [chemical binding]; other site
1423144006066	Mg2+ binding site [ion binding]; other site
1423144006067	G-X-G motif; other site
1423144006068	phosphoribosylformylglycinamidine synthase I; Provisional; Region: PRK03619
1423144006069	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
1423144006070	putative active site [active]
1423144006071	catalytic triad [active]
1423144006072	Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; pfam02700
1423144006073	phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362
1423144006074	bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415
1423144006075	ATP binding site [chemical binding]; other site
1423144006076	active site
1423144006077	substrate binding site [chemical binding]; other site
1423144006078	Domain of unknown function (DUF1476); Region: DUF1476; pfam07345
1423144006079	Predicted integral membrane protein [Function unknown]; Region: COG0392
1423144006080	Uncharacterized conserved protein (DUF2156); Region: DUF2156; pfam09924
1423144006081	methionine synthase I; Validated; Region: PRK07534
1423144006082	Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574
1423144006083	DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533
1423144006084	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1423144006085	FeS/SAM binding site; other site
1423144006086	Predicted cobalamin binding protein [General function prediction only]; Region: COG5012
1423144006087	B12 binding domain of corrinoid proteins. A family of small methanogenic corrinoid proteins that bind methyl-Co(III) 5-hydroxybenzimidazolylcobamide as a cofactor. They play a role on the methanogenesis from trimethylamine, dimethylamine or...; Region: corrinoid_protein_B12-BD; cd02070
1423144006088	B12 binding site [chemical binding]; other site
1423144006089	cobalt ligand [ion binding]; other site
1423144006090	Protein of unknown function (DUF1638); Region: DUF1638; pfam07796
1423144006091	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1423144006092	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1423144006093	C-terminal, alpha helical domain of an unknown subfamily 8 of Glutathione S-transferases; Region: GST_C_8; cd03207
1423144006094	dimer interface [polypeptide binding]; other site
1423144006095	N-terminal domain interface [polypeptide binding]; other site
1423144006096	putative substrate binding pocket (H-site) [chemical binding]; other site
1423144006097	HTH domain; Region: HTH_11; cl17392
1423144006098	WYL domain; Region: WYL; pfam13280
1423144006099	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
1423144006100	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
1423144006101	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
1423144006102	catalytic site [active]
1423144006103	putative active site [active]
1423144006104	putative substrate binding site [chemical binding]; other site
1423144006105	HRDC domain; Region: HRDC; pfam00570
1423144006106	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
1423144006107	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
1423144006108	active site
1423144006109	substrate binding site [chemical binding]; other site
1423144006110	cosubstrate binding site; other site
1423144006111	catalytic site [active]
1423144006112	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
1423144006113	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
1423144006114	dimerization interface [polypeptide binding]; other site
1423144006115	putative ATP binding site [chemical binding]; other site
1423144006116	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1423144006117	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1423144006118	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144006119	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1423144006120	putative effector binding pocket; other site
1423144006121	dimerization interface [polypeptide binding]; other site
1423144006122	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1423144006123	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1423144006124	DNA binding site [nucleotide binding]
1423144006125	domain linker motif; other site
1423144006126	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
1423144006127	dimerization interface [polypeptide binding]; other site
1423144006128	ligand binding site [chemical binding]; other site
1423144006129	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1423144006130	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1423144006131	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1423144006132	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144006133	dimer interface [polypeptide binding]; other site
1423144006134	conserved gate region; other site
1423144006135	putative PBP binding loops; other site
1423144006136	ABC-ATPase subunit interface; other site
1423144006137	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1423144006138	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144006139	dimer interface [polypeptide binding]; other site
1423144006140	conserved gate region; other site
1423144006141	putative PBP binding loops; other site
1423144006142	ABC-ATPase subunit interface; other site
1423144006143	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1423144006144	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1423144006145	Walker A/P-loop; other site
1423144006146	ATP binding site [chemical binding]; other site
1423144006147	Q-loop/lid; other site
1423144006148	ABC transporter signature motif; other site
1423144006149	Walker B; other site
1423144006150	D-loop; other site
1423144006151	H-loop/switch region; other site
1423144006152	TOBE domain; Region: TOBE_2; pfam08402
1423144006153	sorbitol dehydrogenase; Provisional; Region: PRK07067
1423144006154	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1423144006155	NAD(P) binding site [chemical binding]; other site
1423144006156	active site
1423144006157	Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246
1423144006158	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
1423144006159	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
1423144006160	His-Xaa-Ser system putative quinone modification maturase; Region: SAM_quin_mod; TIGR03981
1423144006161	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1423144006162	Sel1-like repeats; Region: SEL1; smart00671
1423144006163	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1423144006164	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
1423144006165	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
1423144006166	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
1423144006167	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
1423144006168	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1423144006169	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1423144006170	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1423144006171	active site
1423144006172	catalytic tetrad [active]
1423144006173	alkanesulfonate monooxygenase, FMNH(2)-dependent; Region: alk_sulf_monoox; TIGR03565
1423144006174	Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094
1423144006175	active site
1423144006176	dimer interface [polypeptide binding]; other site
1423144006177	non-prolyl cis peptide bond; other site
1423144006178	insertion regions; other site
1423144006179	Transcriptional regulators [Transcription]; Region: PhnF; COG2188
1423144006180	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1423144006181	DNA-binding site [nucleotide binding]; DNA binding site
1423144006182	UTRA domain; Region: UTRA; pfam07702
1423144006183	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1423144006184	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1423144006185	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1423144006186	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1423144006187	HAMP domain; Region: HAMP; pfam00672
1423144006188	dimerization interface [polypeptide binding]; other site
1423144006189	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1423144006190	dimer interface [polypeptide binding]; other site
1423144006191	phosphorylation site [posttranslational modification]
1423144006192	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1423144006193	ATP binding site [chemical binding]; other site
1423144006194	Mg2+ binding site [ion binding]; other site
1423144006195	G-X-G motif; other site
1423144006196	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1423144006197	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1423144006198	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
1423144006199	HAMP domain; Region: HAMP; pfam00672
1423144006200	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1423144006201	ATP binding site [chemical binding]; other site
1423144006202	Mg2+ binding site [ion binding]; other site
1423144006203	G-X-G motif; other site
1423144006204	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1423144006205	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144006206	active site
1423144006207	phosphorylation site [posttranslational modification]
1423144006208	intermolecular recognition site; other site
1423144006209	dimerization interface [polypeptide binding]; other site
1423144006210	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1423144006211	DNA binding site [nucleotide binding]
1423144006212	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
1423144006213	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
1423144006214	DctM-like transporters; Region: DctM; pfam06808
1423144006215	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
1423144006216	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
1423144006217	acetyl-CoA synthetase; Provisional; Region: PRK00174
1423144006218	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
1423144006219	active site
1423144006220	CoA binding site [chemical binding]; other site
1423144006221	acyl-activating enzyme (AAE) consensus motif; other site
1423144006222	AMP binding site [chemical binding]; other site
1423144006223	acetate binding site [chemical binding]; other site
1423144006224	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
1423144006225	adenylate kinase; Reviewed; Region: adk; PRK00279
1423144006226	AMP-binding site [chemical binding]; other site
1423144006227	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
1423144006228	Flavin reductase like domain; Region: Flavin_Reduct; smart00903
1423144006229	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
1423144006230	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1423144006231	NMT1/THI5 like; Region: NMT1; pfam09084
1423144006232	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1423144006233	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
1423144006234	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
1423144006235	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144006236	dimer interface [polypeptide binding]; other site
1423144006237	conserved gate region; other site
1423144006238	putative PBP binding loops; other site
1423144006239	ABC-ATPase subunit interface; other site
1423144006240	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
1423144006241	ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293
1423144006242	Walker A/P-loop; other site
1423144006243	ATP binding site [chemical binding]; other site
1423144006244	Q-loop/lid; other site
1423144006245	ABC transporter signature motif; other site
1423144006246	Walker B; other site
1423144006247	D-loop; other site
1423144006248	H-loop/switch region; other site
1423144006249	phenylhydantoinase; Validated; Region: PRK08323
1423144006250	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
1423144006251	tetramer interface [polypeptide binding]; other site
1423144006252	active site
1423144006253	allantoate amidohydrolase; Reviewed; Region: PRK12893
1423144006254	M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884
1423144006255	active site
1423144006256	metal binding site [ion binding]; metal-binding site
1423144006257	dimer interface [polypeptide binding]; other site
1423144006258	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1423144006259	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1423144006260	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
1423144006261	dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318
1423144006262	Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain.  DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940
1423144006263	homodimer interface [polypeptide binding]; other site
1423144006264	active site
1423144006265	FMN binding site [chemical binding]; other site
1423144006266	substrate binding site [chemical binding]; other site
1423144006267	4Fe-4S binding domain; Region: Fer4; cl02805
1423144006268	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
1423144006269	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1423144006270	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1423144006271	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1423144006272	homotrimer interaction site [polypeptide binding]; other site
1423144006273	putative active site [active]
1423144006274	Uncharacterized protein conserved in bacteria (DUF2312); Region: DUF2312; pfam10073
1423144006275	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1423144006276	Predicted transporter component [General function prediction only]; Region: COG2391
1423144006277	Sulphur transport; Region: Sulf_transp; pfam04143
1423144006278	Predicted transporter component [General function prediction only]; Region: COG2391
1423144006279	Sulphur transport; Region: Sulf_transp; pfam04143
1423144006280	Putative phosphatase (DUF442); Region: DUF442; cl17385
1423144006281	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
1423144006282	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
1423144006283	Na binding site [ion binding]; other site
1423144006284	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1423144006285	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1423144006286	dimer interface [polypeptide binding]; other site
1423144006287	phosphorylation site [posttranslational modification]
1423144006288	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1423144006289	ATP binding site [chemical binding]; other site
1423144006290	Mg2+ binding site [ion binding]; other site
1423144006291	G-X-G motif; other site
1423144006292	Response regulator receiver domain; Region: Response_reg; pfam00072
1423144006293	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144006294	active site
1423144006295	phosphorylation site [posttranslational modification]
1423144006296	intermolecular recognition site; other site
1423144006297	dimerization interface [polypeptide binding]; other site
1423144006298	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1423144006299	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1423144006300	non-specific DNA binding site [nucleotide binding]; other site
1423144006301	salt bridge; other site
1423144006302	sequence-specific DNA binding site [nucleotide binding]; other site
1423144006303	Predicted transcriptional regulator (DUF2083); Region: DUF2083; pfam09856
1423144006304	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1423144006305	Periplasmic solute-binding domain of active transport proteins that belong to the type I periplasmic binding fold protein family; Region: PBP1_SBP_like_1; cd06327
1423144006306	putative ligand binding site [chemical binding]; other site
1423144006307	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1423144006308	TM-ABC transporter signature motif; other site
1423144006309	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1423144006310	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1423144006311	TM-ABC transporter signature motif; other site
1423144006312	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1423144006313	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1423144006314	Walker A/P-loop; other site
1423144006315	ATP binding site [chemical binding]; other site
1423144006316	Q-loop/lid; other site
1423144006317	ABC transporter signature motif; other site
1423144006318	Walker B; other site
1423144006319	D-loop; other site
1423144006320	H-loop/switch region; other site
1423144006321	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1423144006322	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1423144006323	Walker A/P-loop; other site
1423144006324	ATP binding site [chemical binding]; other site
1423144006325	Q-loop/lid; other site
1423144006326	ABC transporter signature motif; other site
1423144006327	Walker B; other site
1423144006328	D-loop; other site
1423144006329	H-loop/switch region; other site
1423144006330	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1423144006331	PAS domain; Region: PAS_9; pfam13426
1423144006332	putative active site [active]
1423144006333	heme pocket [chemical binding]; other site
1423144006334	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1423144006335	DNA binding residues [nucleotide binding]
1423144006336	dimerization interface [polypeptide binding]; other site
1423144006337	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
1423144006338	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1423144006339	carboxyltransferase (CT) interaction site; other site
1423144006340	biotinylation site [posttranslational modification]; other site
1423144006341	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
1423144006342	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1423144006343	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
1423144006344	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1423144006345	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
1423144006346	Uncharacterized protein conserved in bacteria (DUF2155); Region: DUF2155; pfam09923
1423144006347	mce related protein; Region: MCE; pfam02470
1423144006348	NADH dehydrogenase; Validated; Region: PRK08183
1423144006349	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015
1423144006350	homotrimer interaction site [polypeptide binding]; other site
1423144006351	putative active site [active]
1423144006352	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
1423144006353	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
1423144006354	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1423144006355	Walker A motif; other site
1423144006356	ATP binding site [chemical binding]; other site
1423144006357	Walker B motif; other site
1423144006358	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1423144006359	Clp protease; Region: CLP_protease; pfam00574
1423144006360	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
1423144006361	oligomer interface [polypeptide binding]; other site
1423144006362	active site residues [active]
1423144006363	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1423144006364	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
1423144006365	conserved cys residue [active]
1423144006366	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1423144006367	Transglycosylase SLT domain; Region: SLT_2; pfam13406
1423144006368	murein hydrolase B; Provisional; Region: PRK10760; cl17906
1423144006369	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
1423144006370	putative chaperone; Provisional; Region: PRK11678
1423144006371	nucleotide binding site [chemical binding]; other site
1423144006372	putative NEF/HSP70 interaction site [polypeptide binding]; other site
1423144006373	SBD interface [polypeptide binding]; other site
1423144006374	Cytochrome c; Region: Cytochrom_C; pfam00034
1423144006375	Cytochrome c2 [Energy production and conversion]; Region: COG3474
1423144006376	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1423144006377	Moco binding site; other site
1423144006378	metal coordination site [ion binding]; other site
1423144006379	Thermus thermophilus SoxB and related proteins, N-terminal metallophosphatase domain; Region: MPP_SoxB_N; cd07411
1423144006380	active site
1423144006381	metal binding site [ion binding]; metal-binding site
1423144006382	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1423144006383	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1423144006384	Cytochrome c [Energy production and conversion]; Region: COG3258
1423144006385	Sulphur oxidation protein SoxZ; Region: SoxZ; pfam08770
1423144006386	sulfur oxidation protein SoxY; Provisional; Region: PRK07474
1423144006387	Sulfur oxidation protein SoxY; Region: SoxY; pfam13501
1423144006388	Cytochrome c; Region: Cytochrom_C; pfam00034
1423144006389	SoxW family; SoxW is a bacterial periplasmic TRX, containing a redox active CXXC motif, encoded by a genetic locus (sox operon) involved in thiosulfate oxidation. Sulfur bacteria oxidize sulfur compounds to provide reducing equivalents for carbon dioxide...; Region: SoxW; cd02951
1423144006390	catalytic residues [active]
1423144006391	Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785
1423144006392	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; pfam02683
1423144006393	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1423144006394	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1423144006395	dimerization interface [polypeptide binding]; other site
1423144006396	putative DNA binding site [nucleotide binding]; other site
1423144006397	putative Zn2+ binding site [ion binding]; other site
1423144006398	Sulphur transport; Region: Sulf_transp; pfam04143
1423144006399	Domain of unknown function DUF302; Region: DUF302; pfam03625
1423144006400	Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028
1423144006401	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1423144006402	PYR/PP interface [polypeptide binding]; other site
1423144006403	dimer interface [polypeptide binding]; other site
1423144006404	TPP binding site [chemical binding]; other site
1423144006405	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1423144006406	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
1423144006407	TPP-binding site [chemical binding]; other site
1423144006408	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1423144006409	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1423144006410	StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804
1423144006411	OpgC protein; Region: OpgC_C; pfam10129
1423144006412	glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274
1423144006413	glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273
1423144006414	glucosyltransferase MdoH; Provisional; Region: PRK05454
1423144006415	active site
1423144006416	Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506
1423144006417	Serine hydrolase (FSH1); Region: FSH1; pfam03959
1423144006418	Calcineurin-binding protein (Calsarcin); Region: Calsarcin; pfam05556
1423144006419	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1423144006420	active site residue [active]
1423144006421	putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12648
1423144006422	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1423144006423	Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111
1423144006424	Domain of unknown function (DUF4040); Region: DUF4040; cl00676
1423144006425	putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK09094
1423144006426	putative monovalent cation/H+ antiporter subunit D; Reviewed; Region: PRK12666
1423144006427	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1423144006428	putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK08965
1423144006429	putative monovalent cation/H+ antiporter subunit F; Reviewed; Region: PRK06161
1423144006430	putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674
1423144006431	pyridine nucleotide-disulfide oxidoreductase family protein; Region: Nterm_to_SelD; TIGR03169
1423144006432	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
1423144006433	selenophosphate synthetase; Provisional; Region: PRK00943
1423144006434	dimerization interface [polypeptide binding]; other site
1423144006435	putative ATP binding site [chemical binding]; other site
1423144006436	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
1423144006437	Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520
1423144006438	active site residue [active]
1423144006439	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1423144006440	MarR family; Region: MarR_2; pfam12802
1423144006441	Domain of unknown function (DUF1992); Region: DUF1992; pfam09350
1423144006442	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
1423144006443	CD73 ecto-5'-nucleotidase and related proteins, N-terminal metallophosphatase domain; Region: MPP_CD73_N; cd07409
1423144006444	active site
1423144006445	metal binding site [ion binding]; metal-binding site
1423144006446	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
1423144006447	Protein of unknown function (DUF952); Region: DUF952; pfam06108
1423144006448	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
1423144006449	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
1423144006450	quinone interaction residues [chemical binding]; other site
1423144006451	active site
1423144006452	catalytic residues [active]
1423144006453	FMN binding site [chemical binding]; other site
1423144006454	substrate binding site [chemical binding]; other site
1423144006455	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
1423144006456	ArsC family; Region: ArsC; pfam03960
1423144006457	catalytic residues [active]
1423144006458	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
1423144006459	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
1423144006460	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1423144006461	CoenzymeA binding site [chemical binding]; other site
1423144006462	subunit interaction site [polypeptide binding]; other site
1423144006463	PHB binding site; other site
1423144006464	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1423144006465	CoenzymeA binding site [chemical binding]; other site
1423144006466	subunit interaction site [polypeptide binding]; other site
1423144006467	PHB binding site; other site
1423144006468	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
1423144006469	DNA binding residues [nucleotide binding]
1423144006470	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1423144006471	putative dimer interface [polypeptide binding]; other site
1423144006472	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
1423144006473	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1423144006474	DNA binding residues [nucleotide binding]
1423144006475	putative dimer interface [polypeptide binding]; other site
1423144006476	Acyl-CoA dehydrogenase N terminal; Region: AcylCoA_DH_N; pfam12418
1423144006477	acyl-CoA dehydrogenase; Provisional; Region: PTZ00456
1423144006478	Putative acyl-CoA dehydrogenases similar to fadE5; Region: ACAD_fadE5; cd01153
1423144006479	FAD binding site [chemical binding]; other site
1423144006480	substrate binding site [chemical binding]; other site
1423144006481	catalytic residues [active]
1423144006482	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
1423144006483	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1423144006484	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1423144006485	active site
1423144006486	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1423144006487	GST_N family, unknown subfamily 4; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_4; cd03056
1423144006488	putative C-terminal domain interface [polypeptide binding]; other site
1423144006489	putative GSH binding site (G-site) [chemical binding]; other site
1423144006490	putative dimer interface [polypeptide binding]; other site
1423144006491	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1423144006492	N-terminal domain interface [polypeptide binding]; other site
1423144006493	dimer interface [polypeptide binding]; other site
1423144006494	substrate binding pocket (H-site) [chemical binding]; other site
1423144006495	acetyl-CoA acetyltransferase; Validated; Region: PRK08242
1423144006496	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1423144006497	dimer interface [polypeptide binding]; other site
1423144006498	active site
1423144006499	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
1423144006500	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1423144006501	substrate binding site [chemical binding]; other site
1423144006502	oxyanion hole (OAH) forming residues; other site
1423144006503	trimer interface [polypeptide binding]; other site
1423144006504	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1423144006505	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1423144006506	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1423144006507	Hint domain; Region: Hint_2; pfam13403
1423144006508	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
1423144006509	acyl-CoA synthetase; Validated; Region: PRK08162
1423144006510	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles and Arabidopsis; Region: ttLC_FACS_AEE21_like; cd12118
1423144006511	acyl-activating enzyme (AAE) consensus motif; other site
1423144006512	putative active site [active]
1423144006513	AMP binding site [chemical binding]; other site
1423144006514	putative CoA binding site [chemical binding]; other site
1423144006515	Sporulation related domain; Region: SPOR; pfam05036
1423144006516	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1423144006517	active site
1423144006518	phosphopentomutase; Provisional; Region: PRK05362
1423144006519	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
1423144006520	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
1423144006521	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
1423144006522	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
1423144006523	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734
1423144006524	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
1423144006525	active site
1423144006526	catalytic motif [active]
1423144006527	Zn binding site [ion binding]; other site
1423144006528	Cupin domain; Region: Cupin_2; cl17218
1423144006529	Cupin; Region: Cupin_6; pfam12852
1423144006530	malic enzyme; Reviewed; Region: PRK12862
1423144006531	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1423144006532	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1423144006533	putative NAD(P) binding site [chemical binding]; other site
1423144006534	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
1423144006535	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
1423144006536	Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967
1423144006537	acyl-activating enzyme (AAE) consensus motif; other site
1423144006538	putative AMP binding site [chemical binding]; other site
1423144006539	putative active site [active]
1423144006540	putative CoA binding site [chemical binding]; other site
1423144006541	amidase; Provisional; Region: PRK07487
1423144006542	Amidase; Region: Amidase; cl11426
1423144006543	ATP-NAD kinase; Region: NAD_kinase; pfam01513
1423144006544	inorganic polyphosphate/ATP-NAD kinase; Reviewed; Region: ppnK; PRK04761
1423144006545	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
1423144006546	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
1423144006547	dimer interface [polypeptide binding]; other site
1423144006548	active site
1423144006549	glycine-pyridoxal phosphate binding site [chemical binding]; other site
1423144006550	folate binding site [chemical binding]; other site
1423144006551	yiaA/B two helix domain; Region: YiaAB; cl01759
1423144006552	Phage shock protein A (IM30), suppresses sigma54-dependent transcription [Transcription / Signal transduction mechanisms]; Region: PspA; COG1842
1423144006553	WHG domain; Region: WHG; pfam13305
1423144006554	acyl-CoA esterase; Provisional; Region: PRK10673
1423144006555	PGAP1-like protein; Region: PGAP1; pfam07819
1423144006556	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
1423144006557	PAS domain; Region: PAS_9; pfam13426
1423144006558	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
1423144006559	putative active site [active]
1423144006560	heme pocket [chemical binding]; other site
1423144006561	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1423144006562	dimer interface [polypeptide binding]; other site
1423144006563	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
1423144006564	putative CheW interface [polypeptide binding]; other site
1423144006565	CHASE domain; Region: CHASE; cl01369
1423144006566	PAS fold; Region: PAS_3; pfam08447
1423144006567	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1423144006568	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1423144006569	dimer interface [polypeptide binding]; other site
1423144006570	phosphorylation site [posttranslational modification]
1423144006571	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1423144006572	ATP binding site [chemical binding]; other site
1423144006573	Mg2+ binding site [ion binding]; other site
1423144006574	G-X-G motif; other site
1423144006575	Response regulator receiver domain; Region: Response_reg; pfam00072
1423144006576	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144006577	active site
1423144006578	phosphorylation site [posttranslational modification]
1423144006579	intermolecular recognition site; other site
1423144006580	dimerization interface [polypeptide binding]; other site
1423144006581	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
1423144006582	integrase; Provisional; Region: PRK09692
1423144006583	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1423144006584	active site
1423144006585	DNA binding site [nucleotide binding]
1423144006586	Int/Topo IB signature motif; other site
1423144006587	Protein of unknown function (DUF1653); Region: DUF1653; cl01949
1423144006588	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
1423144006589	amidase catalytic site [active]
1423144006590	Zn binding residues [ion binding]; other site
1423144006591	substrate binding site [chemical binding]; other site
1423144006592	KilA-N domain; Region: KilA-N; pfam04383
1423144006593	Arc-like DNA binding domain; Region: Arc; pfam03869
1423144006594	Mnt; Region: mnt; PHA01513
1423144006595	P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651
1423144006596	Phage terminase large subunit; Region: Terminase_3; cl12054
1423144006597	N-Utilization Substance G (NusG) N-terminal (NGN) domain Superfamily; Region: NGN; cl02766
1423144006598	HNH endonuclease; Region: HNH_3; pfam13392
1423144006599	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
1423144006600	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
1423144006601	dimer interface [polypeptide binding]; other site
1423144006602	ssDNA binding site [nucleotide binding]; other site
1423144006603	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1423144006604	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
1423144006605	DnaA box-binding interface [nucleotide binding]; other site
1423144006606	T5orf172 domain; Region: T5orf172; pfam10544
1423144006607	VRR-NUC domain; Region: VRR_NUC; cl17748
1423144006608	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1423144006609	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1423144006610	non-specific DNA binding site [nucleotide binding]; other site
1423144006611	salt bridge; other site
1423144006612	sequence-specific DNA binding site [nucleotide binding]; other site
1423144006613	Predicted transcriptional regulator [Transcription]; Region: COG2932
1423144006614	The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cd06462
1423144006615	Catalytic site [active]
1423144006616	ERF superfamily; Region: ERF; pfam04404
1423144006617	Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782
1423144006618	active site
1423144006619	catalytic site [active]
1423144006620	substrate binding site [chemical binding]; other site
1423144006621	Protein of unknown function (DUF1364); Region: DUF1364; pfam07102
1423144006622	ATP-dependent helicase HepA; Validated; Region: PRK04914
1423144006623	Protein of unknown function (DUF551); Region: DUF551; pfam04448
1423144006624	Restriction alleviation protein Lar; Region: Lar_restr_allev; pfam14354
1423144006625	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1423144006626	binding surface
1423144006627	TPR motif; other site
1423144006628	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
1423144006629	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1423144006630	dimerization interface [polypeptide binding]; other site
1423144006631	putative DNA binding site [nucleotide binding]; other site
1423144006632	putative Zn2+ binding site [ion binding]; other site
1423144006633	AsnC family; Region: AsnC_trans_reg; pfam01037
1423144006634	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11905
1423144006635	Proline dehydrogenase; Region: Pro_dh; pfam01619
1423144006636	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
1423144006637	Glutamate binding site [chemical binding]; other site
1423144006638	NAD binding site [chemical binding]; other site
1423144006639	catalytic residues [active]
1423144006640	Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705
1423144006641	Uncharacterized conserved protein [Function unknown]; Region: COG3791
1423144006642	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1423144006643	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
1423144006644	active site
1423144006645	dimerization interface [polypeptide binding]; other site
1423144006646	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
1423144006647	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144006648	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
1423144006649	putative dimerization interface [polypeptide binding]; other site
1423144006650	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
1423144006651	FAD binding site [chemical binding]; other site
1423144006652	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1423144006653	CoenzymeA binding site [chemical binding]; other site
1423144006654	subunit interaction site [polypeptide binding]; other site
1423144006655	PHB binding site; other site
1423144006656	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
1423144006657	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
1423144006658	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1423144006659	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144006660	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1423144006661	dimerization interface [polypeptide binding]; other site
1423144006662	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1423144006663	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1423144006664	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1423144006665	Autotransporter beta-domain; Region: Autotransporter; smart00869
1423144006666	Uncharacterized conserved protein (DUF2235); Region: DUF2235; pfam09994
1423144006667	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
1423144006668	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1423144006669	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1423144006670	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
1423144006671	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
1423144006672	dimer interface [polypeptide binding]; other site
1423144006673	active site
1423144006674	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1423144006675	catalytic residues [active]
1423144006676	substrate binding site [chemical binding]; other site
1423144006677	helix_turn_helix ASNC type; Region: HTH_ASNC; smart00344
1423144006678	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
1423144006679	putative DNA binding site [nucleotide binding]; other site
1423144006680	putative Zn2+ binding site [ion binding]; other site
1423144006681	AsnC family; Region: AsnC_trans_reg; pfam01037
1423144006682	Valyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ValS; COG0525
1423144006683	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
1423144006684	HIGH motif; other site
1423144006685	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1423144006686	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1423144006687	active site
1423144006688	KMSKS motif; other site
1423144006689	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
1423144006690	tRNA binding surface [nucleotide binding]; other site
1423144006691	anticodon binding site; other site
1423144006692	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
1423144006693	Protein of unknown function (DUF1330); Region: DUF1330; cl02288
1423144006694	tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313
1423144006695	putative metal binding site [ion binding]; other site
1423144006696	tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313
1423144006697	putative metal binding site [ion binding]; other site
1423144006698	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
1423144006699	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
1423144006700	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1423144006701	Walker A/P-loop; other site
1423144006702	ATP binding site [chemical binding]; other site
1423144006703	Q-loop/lid; other site
1423144006704	ABC transporter signature motif; other site
1423144006705	Walker B; other site
1423144006706	D-loop; other site
1423144006707	H-loop/switch region; other site
1423144006708	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1423144006709	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1423144006710	substrate binding pocket [chemical binding]; other site
1423144006711	membrane-bound complex binding site; other site
1423144006712	hinge residues; other site
1423144006713	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1423144006714	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144006715	ABC-ATPase subunit interface; other site
1423144006716	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144006717	dimer interface [polypeptide binding]; other site
1423144006718	conserved gate region; other site
1423144006719	putative PBP binding loops; other site
1423144006720	ABC-ATPase subunit interface; other site
1423144006721	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1423144006722	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1423144006723	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
1423144006724	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
1423144006725	catalytic triad [active]
1423144006726	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1423144006727	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1423144006728	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1423144006729	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1423144006730	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1423144006731	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
1423144006732	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1423144006733	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1423144006734	catalytic residue [active]
1423144006735	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
1423144006736	active site
1423144006737	tetramer interface [polypeptide binding]; other site
1423144006738	Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229
1423144006739	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1423144006740	Coenzyme A binding pocket [chemical binding]; other site
1423144006741	enolase; Provisional; Region: eno; PRK00077
1423144006742	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
1423144006743	dimer interface [polypeptide binding]; other site
1423144006744	metal binding site [ion binding]; metal-binding site
1423144006745	substrate binding pocket [chemical binding]; other site
1423144006746	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1423144006747	metal binding site 2 [ion binding]; metal-binding site
1423144006748	putative DNA binding helix; other site
1423144006749	metal binding site 1 [ion binding]; metal-binding site
1423144006750	dimer interface [polypeptide binding]; other site
1423144006751	structural Zn2+ binding site [ion binding]; other site
1423144006752	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
1423144006753	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1423144006754	ATP binding site [chemical binding]; other site
1423144006755	Mg++ binding site [ion binding]; other site
1423144006756	motif III; other site
1423144006757	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1423144006758	nucleotide binding region [chemical binding]; other site
1423144006759	ATP-binding site [chemical binding]; other site
1423144006760	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1423144006761	putative catalytic site [active]
1423144006762	putative metal binding site [ion binding]; other site
1423144006763	putative phosphate binding site [ion binding]; other site
1423144006764	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1423144006765	EamA-like transporter family; Region: EamA; cl17759
1423144006766	EamA-like transporter family; Region: EamA; pfam00892
1423144006767	hypothetical protein; Validated; Region: PRK00029
1423144006768	Uncharacterized conserved protein [Function unknown]; Region: COG0397
1423144006769	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
1423144006770	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
1423144006771	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
1423144006772	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
1423144006773	active site
1423144006774	HIGH motif; other site
1423144006775	dimer interface [polypeptide binding]; other site
1423144006776	KMSKS motif; other site
1423144006777	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
1423144006778	RNA binding surface [nucleotide binding]; other site
1423144006779	Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480
1423144006780	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
1423144006781	17hydroxysteroid dehydrogenase type 10 (HSD10)-like, classical (c) SDRs; Region: HSD10-like_SDR_c; cd05371
1423144006782	NAD binding site [chemical binding]; other site
1423144006783	homodimer interface [polypeptide binding]; other site
1423144006784	homotetramer interface [polypeptide binding]; other site
1423144006785	active site
1423144006786	Uncharacterized conserved protein [Function unknown]; Region: COG3791
1423144006787	maltose O-acetyltransferase; Provisional; Region: PRK10092
1423144006788	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
1423144006789	active site
1423144006790	substrate binding site [chemical binding]; other site
1423144006791	trimer interface [polypeptide binding]; other site
1423144006792	CoA binding site [chemical binding]; other site
1423144006793	ABC transporter ATPase component; Reviewed; Region: PRK11147
1423144006794	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1423144006795	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
1423144006796	Acetyltransferase (GNAT) domain; Region: Acetyltransf_5; pfam13444
1423144006797	Outer membrane lipoprotein OmlA (small protein A) [Cell envelope biogenesis, outer membrane]; Region: OlmA; COG2913
1423144006798	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
1423144006799	Uncharacterized ACR, COG1399; Region: DUF177; pfam02620
1423144006800	50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286
1423144006801	putative phosphate acyltransferase; Provisional; Region: PRK05331
1423144006802	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
1423144006803	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
1423144006804	dimer interface [polypeptide binding]; other site
1423144006805	active site
1423144006806	CoA binding pocket [chemical binding]; other site
1423144006807	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1423144006808	IHF dimer interface [polypeptide binding]; other site
1423144006809	IHF - DNA interface [nucleotide binding]; other site
1423144006810	Helix-Turn-Helix DNA binding domain of putative MlrA-like transcription regulators; Region: HTH_MlrA-like_sg2; cd04765
1423144006811	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
1423144006812	DNA binding residues [nucleotide binding]
1423144006813	2'-deoxycytidine 5'-triphosphate deaminase; Provisional; Region: PRK07559
1423144006814	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
1423144006815	trimer interface [polypeptide binding]; other site
1423144006816	active site
1423144006817	Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cl00493
1423144006818	trimer interface [polypeptide binding]; other site
1423144006819	active site
1423144006820	Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079
1423144006821	Rec8/ScpA/Scc1-like protein (kleisin family) [Replication,    recombination, and repair]; Region: scpA; COG1354
1423144006822	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
1423144006823	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; cl07971
1423144006824	Sporulation related domain; Region: SPOR; pfam05036
1423144006825	arginyl-tRNA synthetase; Reviewed; Region: argS; PRK01611
1423144006826	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
1423144006827	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
1423144006828	active site
1423144006829	HIGH motif; other site
1423144006830	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1423144006831	KMSK motif region; other site
1423144006832	tRNA binding surface [nucleotide binding]; other site
1423144006833	DALR anticodon binding domain; Region: DALR_1; smart00836
1423144006834	anticodon binding site; other site
1423144006835	YCII-related domain; Region: YCII; cl00999
1423144006836	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286
1423144006837	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
1423144006838	Zn2+ binding site [ion binding]; other site
1423144006839	Mg2+ binding site [ion binding]; other site
1423144006840	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
1423144006841	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
1423144006842	Predicted membrane protein [Function unknown]; Region: COG2323
1423144006843	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
1423144006844	putative catalytic site [active]
1423144006845	putative phosphate binding site [ion binding]; other site
1423144006846	active site
1423144006847	metal binding site A [ion binding]; metal-binding site
1423144006848	DNA binding site [nucleotide binding]
1423144006849	putative AP binding site [nucleotide binding]; other site
1423144006850	putative metal binding site B [ion binding]; other site
1423144006851	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1423144006852	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1423144006853	S-adenosylmethionine binding site [chemical binding]; other site
1423144006854	salicylate hydroxylase; Provisional; Region: PRK08163
1423144006855	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1423144006856	RNA polymerase-binding protein DksA; Region: dksA; TIGR02420
1423144006857	ATPases associated with a variety of cellular activities; Region: AAA; smart00382
1423144006858	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1423144006859	Walker A motif; other site
1423144006860	ATP binding site [chemical binding]; other site
1423144006861	Walker B motif; other site
1423144006862	arginine finger; other site
1423144006863	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1423144006864	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1423144006865	DNA binding residues [nucleotide binding]
1423144006866	dimerization interface [polypeptide binding]; other site
1423144006867	MltA-interacting protein MipA; Region: MipA; cl01504
1423144006868	Predicted transcriptional regulator [Transcription]; Region: COG2944
1423144006869	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
1423144006870	salt bridge; other site
1423144006871	non-specific DNA binding site [nucleotide binding]; other site
1423144006872	sequence-specific DNA binding site [nucleotide binding]; other site
1423144006873	Protein of unknown function (DUF2927); Region: DUF2927; pfam11150
1423144006874	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3825
1423144006875	GTPase RsgA; Reviewed; Region: PRK01889
1423144006876	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
1423144006877	GTPase/Zn-binding domain interface [polypeptide binding]; other site
1423144006878	GTP/Mg2+ binding site [chemical binding]; other site
1423144006879	G4 box; other site
1423144006880	G5 box; other site
1423144006881	G1 box; other site
1423144006882	Switch I region; other site
1423144006883	G2 box; other site
1423144006884	G3 box; other site
1423144006885	Switch II region; other site
1423144006886	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1423144006887	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1423144006888	ligand binding site [chemical binding]; other site
1423144006889	Protein containing von Willebrand factor type A (vWA) domain [General function prediction only]; Region: CoxE; COG3552
1423144006890	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1423144006891	metal ion-dependent adhesion site (MIDAS); other site
1423144006892	MoxR-like ATPases [General function prediction only]; Region: COG0714
1423144006893	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1423144006894	Walker A motif; other site
1423144006895	ATP binding site [chemical binding]; other site
1423144006896	Walker B motif; other site
1423144006897	arginine finger; other site
1423144006898	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
1423144006899	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
1423144006900	active site
1423144006901	substrate binding pocket [chemical binding]; other site
1423144006902	dimer interface [polypeptide binding]; other site
1423144006903	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1423144006904	active site
1423144006905	replicative DNA helicase; Provisional; Region: PRK09165
1423144006906	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
1423144006907	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
1423144006908	Walker A motif; other site
1423144006909	ATP binding site [chemical binding]; other site
1423144006910	Walker B motif; other site
1423144006911	DNA binding loops [nucleotide binding]
1423144006912	Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787
1423144006913	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430
1423144006914	active site
1423144006915	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1423144006916	dimer interface [polypeptide binding]; other site
1423144006917	substrate binding site [chemical binding]; other site
1423144006918	catalytic residues [active]
1423144006919	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
1423144006920	Permease; Region: Permease; pfam02405
1423144006921	ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127
1423144006922	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
1423144006923	Walker A/P-loop; other site
1423144006924	ATP binding site [chemical binding]; other site
1423144006925	Q-loop/lid; other site
1423144006926	ABC transporter signature motif; other site
1423144006927	Walker B; other site
1423144006928	D-loop; other site
1423144006929	H-loop/switch region; other site
1423144006930	Paraquat-inducible protein A; Region: PqiA; pfam04403
1423144006931	DNA repair protein RadA; Provisional; Region: PRK11823
1423144006932	Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121
1423144006933	Walker A motif/ATP binding site; other site
1423144006934	ATP binding site [chemical binding]; other site
1423144006935	Walker B motif; other site
1423144006936	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
1423144006937	Colicin V production protein; Region: Colicin_V; pfam02674
1423144006938	Hint domain; Region: Hint_2; pfam13403
1423144006939	amidophosphoribosyltransferase; Provisional; Region: PRK09123
1423144006940	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
1423144006941	active site
1423144006942	tetramer interface [polypeptide binding]; other site
1423144006943	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1423144006944	active site
1423144006945	Uncharacterized protein conserved in bacteria (DUF2199); Region: DUF2199; cl02048
1423144006946	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
1423144006947	classical (c) SDRs; Region: SDR_c; cd05233
1423144006948	NAD(P) binding site [chemical binding]; other site
1423144006949	active site
1423144006950	stationary phase survival protein SurE; Provisional; Region: PRK13931
1423144006951	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
1423144006952	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1423144006953	S-adenosylmethionine binding site [chemical binding]; other site
1423144006954	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1423144006955	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
1423144006956	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
1423144006957	Peptidase family M23; Region: Peptidase_M23; pfam01551
1423144006958	Predicted ATPase (AAA+ superfamily) [General function prediction only]; Region: COG2607
1423144006959	Protein of unknown function (DUF815); Region: DUF815; pfam05673
1423144006960	Walker A motif; other site
1423144006961	ATP binding site [chemical binding]; other site
1423144006962	Walker B motif; other site
1423144006963	Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502
1423144006964	Sec-independent protein secretion pathway component TatC [Intracellular trafficking and secretion]; Region: TatC; COG0805
1423144006965	Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826
1423144006966	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
1423144006967	transport protein sec23; Provisional; Region: PLN00162
1423144006968	Predicted transcriptional regulator [Transcription]; Region: COG2378
1423144006969	HTH domain; Region: HTH_11; pfam08279
1423144006970	WYL domain; Region: WYL; pfam13280
1423144006971	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1423144006972	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
1423144006973	Walker A/P-loop; other site
1423144006974	ATP binding site [chemical binding]; other site
1423144006975	Q-loop/lid; other site
1423144006976	ABC transporter signature motif; other site
1423144006977	Walker B; other site
1423144006978	D-loop; other site
1423144006979	H-loop/switch region; other site
1423144006980	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
1423144006981	short chain dehydrogenase; Provisional; Region: PRK08339
1423144006982	putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR)-like, SDR; Region: BKR_like_SDR_like; cd05344
1423144006983	putative NAD(P) binding site [chemical binding]; other site
1423144006984	putative active site [active]
1423144006985	Hedgehog/Intein domain, found in Hedgehog proteins as well as proteins which contain inteins and undergo protein splicing (e.g. DnaB, RIR1-2, GyrA and Pol). In protein splicing an intervening polypeptide sequence - the intein - is excised from a protein; Region: Hint; cd00081
1423144006986	protein-splicing catalytic site; other site
1423144006987	thioester formation/cholesterol transfer; other site
1423144006988	SnoaL-like domain; Region: SnoaL_2; pfam12680
1423144006989	peptide chain release factor 3; Provisional; Region: prfC; PRK00741
1423144006990	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
1423144006991	G1 box; other site
1423144006992	putative GEF interaction site [polypeptide binding]; other site
1423144006993	GTP/Mg2+ binding site [chemical binding]; other site
1423144006994	Switch I region; other site
1423144006995	G2 box; other site
1423144006996	G3 box; other site
1423144006997	Switch II region; other site
1423144006998	G4 box; other site
1423144006999	G5 box; other site
1423144007000	RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689
1423144007001	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
1423144007002	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1423144007003	DEAD-like helicases superfamily; Region: DEXDc; smart00487
1423144007004	ATP binding site [chemical binding]; other site
1423144007005	Mg++ binding site [ion binding]; other site
1423144007006	motif III; other site
1423144007007	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1423144007008	nucleotide binding region [chemical binding]; other site
1423144007009	ATP-binding site [chemical binding]; other site
1423144007010	mRNA degradation ribonucleases J1/J2 (metallo-beta-lactamase superfamily) [Translation, ribosomal structure and biogenesis; Replication, recombination and repair]; Region: COG0595
1423144007011	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1423144007012	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
1423144007013	pantothenate kinase; Reviewed; Region: PRK13318
1423144007014	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
1423144007015	Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340
1423144007016	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
1423144007017	NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777
1423144007018	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1423144007019	NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846
1423144007020	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1423144007021	proton-translocating NADH-quinone oxidoreductase, chain L; Region: NDH_I_L; TIGR01974
1423144007022	NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662
1423144007023	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1423144007024	NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715
1423144007025	NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638
1423144007026	NADH dehydrogenase subunit J; Provisional; Region: PRK06433
1423144007027	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
1423144007028	NADH dehydrogenase subunit I; Provisional; Region: PRK05888
1423144007029	4Fe-4S binding domain; Region: Fer4; pfam00037
1423144007030	4Fe-4S binding domain; Region: Fer4; pfam00037
1423144007031	NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076
1423144007032	Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650
1423144007033	NADH dehydrogenase subunit G; Validated; Region: PRK09130
1423144007034	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1423144007035	catalytic loop [active]
1423144007036	iron binding site [ion binding]; other site
1423144007037	NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588
1423144007038	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
1423144007039	molybdopterin cofactor binding site; other site
1423144007040	Domain of unknown function (DUF1982); Region: DUF1982; pfam09326
1423144007041	NADH dehydrogenase I subunit F; Provisional; Region: PRK13596
1423144007042	SLBB domain; Region: SLBB; pfam10531
1423144007043	NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928
1423144007044	NADH dehydrogenase subunit E; Provisional; Region: PRK12373
1423144007045	TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064
1423144007046	putative dimer interface [polypeptide binding]; other site
1423144007047	[2Fe-2S] cluster binding site [ion binding]; other site
1423144007048	Uncharacterized conserved protein [Function unknown]; Region: COG3743
1423144007049	NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649
1423144007050	NADH dehydrogenase subunit D; Validated; Region: PRK06075
1423144007051	NADH dehydrogenase subunit C; Provisional; Region: PRK06074
1423144007052	NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961
1423144007053	NADH dehydrogenase subunit B; Validated; Region: PRK06411
1423144007054	NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602
1423144007055	enoyl-CoA hydratase; Provisional; Region: PRK07468
1423144007056	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1423144007057	substrate binding site [chemical binding]; other site
1423144007058	oxyanion hole (OAH) forming residues; other site
1423144007059	trimer interface [polypeptide binding]; other site
1423144007060	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
1423144007061	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
1423144007062	active site
1423144007063	catalytic residues [active]
1423144007064	metal binding site [ion binding]; metal-binding site
1423144007065	Acetyl/propionyl-CoA carboxylase, alpha subunit [Lipid metabolism]; Region: COG4770
1423144007066	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1423144007067	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1423144007068	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1423144007069	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1423144007070	carboxyltransferase (CT) interaction site; other site
1423144007071	biotinylation site [posttranslational modification]; other site
1423144007072	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
1423144007073	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
1423144007074	Uncharacterized subfamily of medium-chain acyl-CoA synthetase (MACS); Region: MACS_like_3; cd05971
1423144007075	active site
1423144007076	acyl-activating enzyme (AAE) consensus motif; other site
1423144007077	putative CoA binding site [chemical binding]; other site
1423144007078	AMP binding site [chemical binding]; other site
1423144007079	OmpW family; Region: OmpW; cl17427
1423144007080	isovaleryl-CoA dehydrogenase; Region: PLN02519
1423144007081	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
1423144007082	substrate binding site [chemical binding]; other site
1423144007083	FAD binding site [chemical binding]; other site
1423144007084	catalytic base [active]
1423144007085	MG2 domain; Region: A2M_N; pfam01835
1423144007086	Hint domain; Region: Hint_2; pfam13403
1423144007087	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
1423144007088	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1423144007089	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1423144007090	catalytic residue [active]
1423144007091	phosphoglycolate phosphatase; Provisional; Region: PRK13222
1423144007092	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
1423144007093	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1423144007094	motif II; other site
1423144007095	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK14353
1423144007096	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
1423144007097	Substrate binding site; other site
1423144007098	Mg++ binding site; other site
1423144007099	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
1423144007100	active site
1423144007101	substrate binding site [chemical binding]; other site
1423144007102	CoA binding site [chemical binding]; other site
1423144007103	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
1423144007104	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
1423144007105	glutaminase active site [active]
1423144007106	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
1423144007107	dimer interface [polypeptide binding]; other site
1423144007108	active site
1423144007109	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
1423144007110	dimer interface [polypeptide binding]; other site
1423144007111	active site
1423144007112	DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713
1423144007113	A new structural DNA glycosylase; Region: AlkD_like; cd06561
1423144007114	active site
1423144007115	molybdenum cofactor biosynthesis protein A; Provisional; Region: PRK13361
1423144007116	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1423144007117	FeS/SAM binding site; other site
1423144007118	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
1423144007119	3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519
1423144007120	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
1423144007121	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1423144007122	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1423144007123	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1423144007124	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
1423144007125	metal binding site [ion binding]; metal-binding site
1423144007126	putative dimer interface [polypeptide binding]; other site
1423144007127	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1423144007128	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
1423144007129	metal binding site [ion binding]; metal-binding site
1423144007130	putative dimer interface [polypeptide binding]; other site
1423144007131	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1423144007132	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
1423144007133	metal binding site [ion binding]; metal-binding site
1423144007134	putative dimer interface [polypeptide binding]; other site
1423144007135	acetylornithine deacetylase; Provisional; Region: PRK07522
1423144007136	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
1423144007137	metal binding site [ion binding]; metal-binding site
1423144007138	putative dimer interface [polypeptide binding]; other site
1423144007139	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1423144007140	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1423144007141	Walker A/P-loop; other site
1423144007142	ATP binding site [chemical binding]; other site
1423144007143	Q-loop/lid; other site
1423144007144	ABC transporter signature motif; other site
1423144007145	Walker B; other site
1423144007146	D-loop; other site
1423144007147	H-loop/switch region; other site
1423144007148	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1423144007149	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1423144007150	Walker A/P-loop; other site
1423144007151	ATP binding site [chemical binding]; other site
1423144007152	Q-loop/lid; other site
1423144007153	ABC transporter signature motif; other site
1423144007154	Walker B; other site
1423144007155	D-loop; other site
1423144007156	H-loop/switch region; other site
1423144007157	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
1423144007158	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1423144007159	The substrate-binding component of ABC-type thermophilic oligopeptide-binding protein Hb8-like import systems, contains the type 2 periplasmic binding fold; Region: PBP2_thermophilic_Hb8_like; cd08513
1423144007160	peptide binding site [polypeptide binding]; other site
1423144007161	dimer interface [polypeptide binding]; other site
1423144007162	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1423144007163	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144007164	dimer interface [polypeptide binding]; other site
1423144007165	conserved gate region; other site
1423144007166	putative PBP binding loops; other site
1423144007167	ABC-ATPase subunit interface; other site
1423144007168	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1423144007169	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1423144007170	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144007171	dimer interface [polypeptide binding]; other site
1423144007172	conserved gate region; other site
1423144007173	putative PBP binding loops; other site
1423144007174	ABC-ATPase subunit interface; other site
1423144007175	Predicted transporter component [General function prediction only]; Region: COG2391
1423144007176	Sulphur transport; Region: Sulf_transp; pfam04143
1423144007177	Protein of unknown function (DUF3422); Region: DUF3422; pfam11902
1423144007178	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
1423144007179	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
1423144007180	Helix-Turn-Helix DNA binding domain of the MerR-like transcription regulators YyaN and YraB; Region: HTH_YyaN; cd01109
1423144007181	DNA binding residues [nucleotide binding]
1423144007182	putative dimer interface [polypeptide binding]; other site
1423144007183	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1423144007184	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1423144007185	active site
1423144007186	NAD/NADP transhydrogenase beta subunit [Energy production and conversion]; Region: PntB; cl00566
1423144007187	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
1423144007188	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
1423144007189	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
1423144007190	ligand binding site [chemical binding]; other site
1423144007191	homodimer interface [polypeptide binding]; other site
1423144007192	NAD(P) binding site [chemical binding]; other site
1423144007193	trimer interface B [polypeptide binding]; other site
1423144007194	trimer interface A [polypeptide binding]; other site
1423144007195	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
1423144007196	Phospholipid methyltransferase; Region: PEMT; cl17370
1423144007197	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1423144007198	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1423144007199	classical (c) SDRs; Region: SDR_c; cd05233
1423144007200	NAD(P) binding site [chemical binding]; other site
1423144007201	active site
1423144007202	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
1423144007203	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1423144007204	kynureninase; Region: kynureninase; TIGR01814
1423144007205	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1423144007206	catalytic residue [active]
1423144007207	tryptophan 2,3-dioxygenase; Region: trp_2_3_diox; TIGR03036
1423144007208	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1423144007209	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1423144007210	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
1423144007211	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1423144007212	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1423144007213	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
1423144007214	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1423144007215	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1423144007216	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1423144007217	Predicted glutamine amidotransferases [General function prediction only]; Region: COG2071
1423144007218	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745
1423144007219	catalytic triad [active]
1423144007220	Domain of unknown function (DUF336); Region: DUF336; cl01249
1423144007221	malate synthase G; Provisional; Region: PRK02999
1423144007222	active site
1423144007223	aminopeptidase N; Provisional; Region: pepN; PRK14015
1423144007224	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
1423144007225	active site
1423144007226	Zn binding site [ion binding]; other site
1423144007227	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
1423144007228	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
1423144007229	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
1423144007230	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
1423144007231	RNA binding site [nucleotide binding]; other site
1423144007232	aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477
1423144007233	GatB/GatE catalytic domain; Region: GatB_N; pfam02934
1423144007234	GatB domain; Region: GatB_Yqey; smart00845
1423144007235	Stress-induced morphogen (activity unknown) [Signal transduction mechanisms]; Region: BolA; COG0271
1423144007236	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1423144007237	HSP70 interaction site [polypeptide binding]; other site
1423144007238	Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354
1423144007239	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1423144007240	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
1423144007241	ATP binding site [chemical binding]; other site
1423144007242	Mg++ binding site [ion binding]; other site
1423144007243	motif III; other site
1423144007244	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1423144007245	nucleotide binding region [chemical binding]; other site
1423144007246	ATP-binding site [chemical binding]; other site
1423144007247	RNA recognition motif in the DbpA subfamily of prokaryotic DEAD-box rRNA helicases; Region: RRM_DbpA; cd12252
1423144007248	RNA binding site [nucleotide binding]; other site
1423144007249	Cobaltochelatase CobS subunit N terminal; Region: CobS_N; pfam12556
1423144007250	cobaltochelatase, CobS subunit; Region: PD_CobS; TIGR01650
1423144007251	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1423144007252	Cobalamin biosynthesis protein CobT; Region: CobT; pfam06213
1423144007253	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
1423144007254	metal ion-dependent adhesion site (MIDAS); other site
1423144007255	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1423144007256	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1423144007257	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
1423144007258	active site
1423144007259	Domain of unknown function (DUF427); Region: DUF427; pfam04248
1423144007260	CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400
1423144007261	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
1423144007262	Cl- selectivity filter; other site
1423144007263	Cl- binding residues [ion binding]; other site
1423144007264	pore gating glutamate residue; other site
1423144007265	dimer interface [polypeptide binding]; other site
1423144007266	ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497
1423144007267	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1423144007268	Walker A/P-loop; other site
1423144007269	ATP binding site [chemical binding]; other site
1423144007270	Q-loop/lid; other site
1423144007271	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
1423144007272	ABC transporter signature motif; other site
1423144007273	Walker B; other site
1423144007274	D-loop; other site
1423144007275	H-loop/switch region; other site
1423144007276	outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302
1423144007277	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
1423144007278	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
1423144007279	cell division protein FtsZ; Validated; Region: PRK09330
1423144007280	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
1423144007281	nucleotide binding site [chemical binding]; other site
1423144007282	SulA interaction site; other site
1423144007283	Cell division protein FtsA; Region: FtsA; smart00842
1423144007284	Cell division ATPase FtsA [Cell division and chromosome partitioning]; Region: ftsA; COG0849
1423144007285	Cell division protein FtsA; Region: FtsA; pfam14450
1423144007286	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
1423144007287	Cell division protein FtsQ; Region: FtsQ; pfam03799
1423144007288	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
1423144007289	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
1423144007290	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1423144007291	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905
1423144007292	FAD binding domain; Region: FAD_binding_4; pfam01565
1423144007293	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
1423144007294	Protein of unknown function (DUF2484); Region: DUF2484; pfam10658
1423144007295	Protein of unknown function (DUF2484); Region: DUF2484; pfam10658
1423144007296	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
1423144007297	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1423144007298	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1423144007299	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1423144007300	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
1423144007301	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
1423144007302	active site
1423144007303	homodimer interface [polypeptide binding]; other site
1423144007304	cell division protein FtsW; Region: ftsW; TIGR02614
1423144007305	Predicted flavoproteins [General function prediction only]; Region: COG2081
1423144007306	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1423144007307	Uncharacterized conserved protein [Function unknown]; Region: COG1359
1423144007308	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
1423144007309	MarR family; Region: MarR_2; pfam12802
1423144007310	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK01390
1423144007311	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
1423144007312	NAD(P) binding pocket [chemical binding]; other site
1423144007313	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1423144007314	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1423144007315	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
1423144007316	glutaminase; Provisional; Region: PRK00971
1423144007317	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
1423144007318	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
1423144007319	Mg++ binding site [ion binding]; other site
1423144007320	putative catalytic motif [active]
1423144007321	putative substrate binding site [chemical binding]; other site
1423144007322	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1423144007323	UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase; Provisional; Region: PRK14093
1423144007324	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1423144007325	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
1423144007326	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
1423144007327	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
1423144007328	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
1423144007329	Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768
1423144007330	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
1423144007331	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
1423144007332	Predicted secreted (periplasmic) protein [Function unknown]; Region: COG5462
1423144007333	MraW methylase family; Region: Methyltransf_5; cl17771
1423144007334	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
1423144007335	cell division protein MraZ; Reviewed; Region: PRK00326
1423144007336	MraZ protein; Region: MraZ; pfam02381
1423144007337	MraZ protein; Region: MraZ; pfam02381
1423144007338	Domain of unknown function DUF59; Region: DUF59; pfam01883
1423144007339	cell division ATPase MinD, archaeal; Region: minD_arch; TIGR01969
1423144007340	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
1423144007341	Domain of unknown function (DUF1127); Region: DUF1127; pfam06568
1423144007342	ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073
1423144007343	Part of AAA domain; Region: AAA_19; pfam13245
1423144007344	Family description; Region: UvrD_C_2; pfam13538
1423144007345	FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203
1423144007346	GAF domain; Region: GAF_3; pfam13492
1423144007347	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1423144007348	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1423144007349	metal binding site [ion binding]; metal-binding site
1423144007350	active site
1423144007351	I-site; other site
1423144007352	Isopentenyl diphosphate isomerase (BS_ypgA, MTH48 and related proteins) [Coenzyme transport and metabolism]; Region: idi; COG1304
1423144007353	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
1423144007354	phosphate binding site [ion binding]; other site
1423144007355	pyruvate carboxylase; Reviewed; Region: PRK12999
1423144007356	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
1423144007357	ATP-grasp domain; Region: ATP-grasp_4; cl17255
1423144007358	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
1423144007359	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
1423144007360	active site
1423144007361	catalytic residues [active]
1423144007362	metal binding site [ion binding]; metal-binding site
1423144007363	homodimer binding site [polypeptide binding]; other site
1423144007364	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
1423144007365	carboxyltransferase (CT) interaction site; other site
1423144007366	biotinylation site [posttranslational modification]; other site
1423144007367	Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315
1423144007368	DNA-methyltransferase (dcm); Region: dcm; TIGR00675
1423144007369	cofactor binding site; other site
1423144007370	DNA binding site [nucleotide binding]
1423144007371	substrate interaction site [chemical binding]; other site
1423144007372	Restriction endonuclease NaeI; Region: NaeI; pfam09126
1423144007373	aminotransferase; Provisional; Region: PRK06105
1423144007374	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1423144007375	inhibitor-cofactor binding pocket; inhibition site
1423144007376	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144007377	catalytic residue [active]
1423144007378	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1423144007379	AsnC family; Region: AsnC_trans_reg; pfam01037
1423144007380	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
1423144007381	putative active site pocket [active]
1423144007382	4-fold oligomerization interface [polypeptide binding]; other site
1423144007383	metal binding residues [ion binding]; metal-binding site
1423144007384	3-fold/trimer interface [polypeptide binding]; other site
1423144007385	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13146
1423144007386	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
1423144007387	putative active site [active]
1423144007388	oxyanion strand; other site
1423144007389	catalytic triad [active]
1423144007390	Cupin; Region: Cupin_6; pfam12852
1423144007391	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1423144007392	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1423144007393	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1423144007394	Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970
1423144007395	putative catalytic residues [active]
1423144007396	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
1423144007397	Uncharacterized protein conserved in bacteria (DUF2147); Region: DUF2147; pfam09917
1423144007398	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
1423144007399	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1423144007400	catalytic residues [active]
1423144007401	Domain of unknown function DUF302; Region: DUF302; pfam03625
1423144007402	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
1423144007403	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
1423144007404	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
1423144007405	substrate binding site [chemical binding]; other site
1423144007406	glutamase interaction surface [polypeptide binding]; other site
1423144007407	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
1423144007408	metal binding site [ion binding]; metal-binding site
1423144007409	Predicted CoA-binding protein [General function prediction only]; Region: COG1832
1423144007410	rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186
1423144007411	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967
1423144007412	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
1423144007413	Protein of unknown function (DUF2478); Region: DUF2478; pfam10649
1423144007414	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
1423144007415	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1423144007416	S-adenosylmethionine binding site [chemical binding]; other site
1423144007417	Protein of unknown function (DUF452); Region: DUF452; cl01062
1423144007418	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1423144007419	adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508
1423144007420	inhibitor-cofactor binding pocket; inhibition site
1423144007421	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144007422	catalytic residue [active]
1423144007423	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
1423144007424	AAA domain; Region: AAA_26; pfam13500
1423144007425	8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958
1423144007426	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1423144007427	catalytic residue [active]
1423144007428	biotin synthase; Region: bioB; TIGR00433
1423144007429	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1423144007430	FeS/SAM binding site; other site
1423144007431	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
1423144007432	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
1423144007433	ThiC-associated domain; Region: ThiC-associated; pfam13667
1423144007434	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
1423144007435	glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352
1423144007436	ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565
1423144007437	thiS-thiF/thiG interaction site; other site
1423144007438	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
1423144007439	ThiS interaction site; other site
1423144007440	putative active site [active]
1423144007441	tetramer interface [polypeptide binding]; other site
1423144007442	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
1423144007443	thiamine phosphate binding site [chemical binding]; other site
1423144007444	active site
1423144007445	pyrophosphate binding site [ion binding]; other site
1423144007446	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
1423144007447	thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356
1423144007448	ATP binding site [chemical binding]; other site
1423144007449	substrate interface [chemical binding]; other site
1423144007450	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1423144007451	active site residue [active]
1423144007452	ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192
1423144007453	substrate binding site [chemical binding]; other site
1423144007454	ATP binding site [chemical binding]; other site
1423144007455	Cache domain; Region: Cache_2; pfam08269
1423144007456	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1423144007457	dimerization interface [polypeptide binding]; other site
1423144007458	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1423144007459	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1423144007460	dimer interface [polypeptide binding]; other site
1423144007461	putative CheW interface [polypeptide binding]; other site
1423144007462	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
1423144007463	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1423144007464	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1423144007465	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1423144007466	DNA binding residues [nucleotide binding]
1423144007467	pseudouridine synthase, RluA family; Region: rluA_subfam; TIGR00005
1423144007468	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1423144007469	RNA binding surface [nucleotide binding]; other site
1423144007470	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1423144007471	active site
1423144007472	Protein of unknown function (DUF1052); Region: DUF1052; cl02197
1423144007473	transcription antitermination factor NusB; Region: nusB; TIGR01951
1423144007474	putative RNA binding site [nucleotide binding]; other site
1423144007475	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
1423144007476	homopentamer interface [polypeptide binding]; other site
1423144007477	active site
1423144007478	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
1423144007479	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
1423144007480	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
1423144007481	dimerization interface [polypeptide binding]; other site
1423144007482	active site
1423144007483	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
1423144007484	Lumazine binding domain; Region: Lum_binding; pfam00677
1423144007485	Lumazine binding domain; Region: Lum_binding; pfam00677
1423144007486	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562
1423144007487	Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159
1423144007488	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
1423144007489	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
1423144007490	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563
1423144007491	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562
1423144007492	riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326
1423144007493	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
1423144007494	catalytic motif [active]
1423144007495	Zn binding site [ion binding]; other site
1423144007496	RibD C-terminal domain; Region: RibD_C; cl17279
1423144007497	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
1423144007498	ATP cone domain; Region: ATP-cone; pfam03477
1423144007499	Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894
1423144007500	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1423144007501	NAD(P) binding site [chemical binding]; other site
1423144007502	active site
1423144007503	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
1423144007504	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
1423144007505	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
1423144007506	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
1423144007507	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1423144007508	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
1423144007509	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1423144007510	DNA binding residues [nucleotide binding]
1423144007511	DNA primase, catalytic core; Region: dnaG; TIGR01391
1423144007512	CHC2 zinc finger; Region: zf-CHC2; cl17510
1423144007513	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
1423144007514	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
1423144007515	active site
1423144007516	metal binding site [ion binding]; metal-binding site
1423144007517	interdomain interaction site; other site
1423144007518	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
1423144007519	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
1423144007520	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
1423144007521	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
1423144007522	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1423144007523	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1423144007524	Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267
1423144007525	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
1423144007526	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1423144007527	Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334
1423144007528	Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812
1423144007529	NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076
1423144007530	NAD(P) binding site [chemical binding]; other site
1423144007531	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1423144007532	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
1423144007533	TadE-like protein; Region: TadE; pfam07811
1423144007534	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
1423144007535	Pirin-related protein [General function prediction only]; Region: COG1741
1423144007536	Pirin; Region: Pirin; pfam02678
1423144007537	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
1423144007538	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1423144007539	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1423144007540	homoserine dehydrogenase; Provisional; Region: PRK06349
1423144007541	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1423144007542	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
1423144007543	ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881
1423144007544	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
1423144007545	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
1423144007546	putative active site [active]
1423144007547	single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644
1423144007548	DHH family; Region: DHH; pfam01368
1423144007549	DHHA1 domain; Region: DHHA1; pfam02272
1423144007550	Heme NO binding associated; Region: HNOBA; pfam07701
1423144007551	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
1423144007552	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1423144007553	metal binding site [ion binding]; metal-binding site
1423144007554	active site
1423144007555	I-site; other site
1423144007556	Heme NO binding; Region: HNOB; pfam07700
1423144007557	Domain of unknown function (DUF4153); Region: DUF4153; pfam13687
1423144007558	Trimethylamine methyltransferase (MTTB); Region: MTTB; cl15385
1423144007559	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
1423144007560	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1423144007561	motif II; other site
1423144007562	Protein of unknown function (DUF3572); Region: DUF3572; pfam12096
1423144007563	response regulator PleD; Reviewed; Region: pleD; PRK09581
1423144007564	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144007565	active site
1423144007566	phosphorylation site [posttranslational modification]
1423144007567	intermolecular recognition site; other site
1423144007568	dimerization interface [polypeptide binding]; other site
1423144007569	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
1423144007570	metal binding site [ion binding]; metal-binding site
1423144007571	active site
1423144007572	I-site; other site
1423144007573	Heavy-metal resistance; Region: Metal_resist; pfam13801
1423144007574	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1423144007575	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1423144007576	DNA binding residues [nucleotide binding]
1423144007577	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
1423144007578	Ca2+ binding site [ion binding]; other site
1423144007579	Protein of unknown function (DUF983); Region: DUF983; cl02211
1423144007580	NUDIX domain; Region: NUDIX; pfam00293
1423144007581	nudix motif; other site
1423144007582	Fatty acid desaturase [Lipid metabolism]; Region: DesA; COG3239
1423144007583	The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615
1423144007584	putative di-iron ligands [ion binding]; other site
1423144007585	Predicted membrane protein (DUF2061); Region: DUF2061; cl01257
1423144007586	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1423144007587	non-specific DNA binding site [nucleotide binding]; other site
1423144007588	salt bridge; other site
1423144007589	sequence-specific DNA binding site [nucleotide binding]; other site
1423144007590	3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429
1423144007591	classical (c) SDRs; Region: SDR_c; cd05233
1423144007592	NAD(P) binding site [chemical binding]; other site
1423144007593	active site
1423144007594	bifunctional 3-hydroxyacyl-CoA dehydrogenase/thioesterase; Validated; Region: PRK07531
1423144007595	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1423144007596	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1423144007597	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1423144007598	active site
1423144007599	Uncharacterized conserved protein [Function unknown]; Region: COG3246
1423144007600	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1423144007601	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
1423144007602	conserved cys residue [active]
1423144007603	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1423144007604	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
1423144007605	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
1423144007606	active site
1423144007607	catalytic tetrad [active]
1423144007608	Polysulfide-sulfurtransferase - Rhodanese Homology Domain. This domain is believed to serve as a polysulfide binding and transferase domain in anaerobic gram-negative bacteria, functioning in oxidative phosphorylation with polysulfide-sulfur as a...; Region: Polysulfide_ST; cd01447
1423144007609	active site
1423144007610	catalytic residue [active]
1423144007611	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1423144007612	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1423144007613	putative substrate translocation pore; other site
1423144007614	methionyl-tRNA synthetase; Reviewed; Region: PRK12268
1423144007615	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
1423144007616	active site
1423144007617	HIGH motif; other site
1423144007618	KMSKS motif; other site
1423144007619	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
1423144007620	tRNA binding surface [nucleotide binding]; other site
1423144007621	anticodon binding site; other site
1423144007622	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
1423144007623	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
1423144007624	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1423144007625	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144007626	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1423144007627	dimerization interface [polypeptide binding]; other site
1423144007628	Hemin uptake protein hemP; Region: hemP; pfam10636
1423144007629	Imelysin; Region: Peptidase_M75; cl09159
1423144007630	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
1423144007631	Protein of unknown function (DUF1111); Region: DUF1111; pfam06537
1423144007632	Imelysin; Region: Peptidase_M75; pfam09375
1423144007633	Protein of unknown function (DUF1513); Region: DUF1513; pfam07433
1423144007634	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
1423144007635	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
1423144007636	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1423144007637	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
1423144007638	Predicted transcriptional regulators [Transcription]; Region: COG1733
1423144007639	Predicted transcriptional regulators [Transcription]; Region: COG1733
1423144007640	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1423144007641	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1423144007642	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1423144007643	active site
1423144007644	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1423144007645	active site
1423144007646	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
1423144007647	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
1423144007648	homodimer interface [polypeptide binding]; other site
1423144007649	Walker A motif; other site
1423144007650	ATP binding site [chemical binding]; other site
1423144007651	hydroxycobalamin binding site [chemical binding]; other site
1423144007652	Walker B motif; other site
1423144007653	Protein of unknown function (DUF1636); Region: DUF1636; pfam07845
1423144007654	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
1423144007655	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1423144007656	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1423144007657	cobaltochelatase subunit CobN; Reviewed; Region: cobN; PRK12321
1423144007658	CobN subunit of cobaltochelatase, bchH and chlH subunits of magnesium chelatases, and similar proteins; Region: CobN_like; cd10150
1423144007659	precorrin-3B synthase; Region: CobG; TIGR02435
1423144007660	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
1423144007661	precorrin-8X methylmutase; Reviewed; Region: cobH; PRK08285
1423144007662	Precorrin-8X methylmutase; Region: CbiC; pfam02570
1423144007663	Precorrin-2 C20-methyltransferase, also named CobI or CbiL; Region: Precorrin_2_C20_MT; cd11645
1423144007664	active site
1423144007665	SAM binding site [chemical binding]; other site
1423144007666	homodimer interface [polypeptide binding]; other site
1423144007667	Precorrin-3B C(17)-methyltransferase (CobJ/CbiH); Region: Precorrin_3B_C17_MT; cd11646
1423144007668	active site
1423144007669	SAM binding site [chemical binding]; other site
1423144007670	homodimer interface [polypeptide binding]; other site
1423144007671	Precorrin-6x reductase CbiJ/CobK; Region: CbiJ; pfam02571
1423144007672	Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644
1423144007673	putative homodimer interface [polypeptide binding]; other site
1423144007674	active site
1423144007675	SAM binding site [chemical binding]; other site
1423144007676	Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242
1423144007677	precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit; Region: CbiT; TIGR02469
1423144007678	Cobalamin synthesis G C-terminus; Region: CbiG_C; pfam01890
1423144007679	Precorrin-4 C11-methyltransferase (CbiF/CobM); Region: Precorrin-4_C11-MT; cd11641
1423144007680	active site
1423144007681	SAM binding site [chemical binding]; other site
1423144007682	homodimer interface [polypeptide binding]; other site
1423144007683	cobyrinic acid a,c-diamide synthase; Validated; Region: PRK01077
1423144007684	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1423144007685	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyrinic Acid a,c-Diamide Synthase; Region: GATase1_CobB; cd03130
1423144007686	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
1423144007687	active site
1423144007688	SAM binding site [chemical binding]; other site
1423144007689	homodimer interface [polypeptide binding]; other site
1423144007690	Precorrin-6A synthase, the cobalamin biosynthesis enzyme CobF; Region: Precorrin-6A-synthase; cd11643
1423144007691	active site
1423144007692	SAM binding site [chemical binding]; other site
1423144007693	homodimer interface [polypeptide binding]; other site
1423144007694	Sporulation related domain; Region: SPOR; pfam05036
1423144007695	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
1423144007696	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
1423144007697	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936
1423144007698	thymidylate kinase; Validated; Region: tmk; PRK00698
1423144007699	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
1423144007700	TMP-binding site; other site
1423144007701	ATP-binding site [chemical binding]; other site
1423144007702	DNA polymerase III subunit delta'; Validated; Region: PRK07471
1423144007703	DNA polymerase III subunit delta'; Validated; Region: PRK08485
1423144007704	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
1423144007705	active site
1423144007706	Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235
1423144007707	putative hydrolase; Provisional; Region: PRK02113
1423144007708	Predicted permeases [General function prediction only]; Region: COG0679
1423144007709	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
1423144007710	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
1423144007711	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
1423144007712	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1423144007713	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144007714	active site
1423144007715	phosphorylation site [posttranslational modification]
1423144007716	intermolecular recognition site; other site
1423144007717	dimerization interface [polypeptide binding]; other site
1423144007718	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1423144007719	DNA binding site [nucleotide binding]
1423144007720	Two-component sensor kinase N-terminal; Region: 2CSK_N; pfam08521
1423144007721	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1423144007722	HAMP domain; Region: HAMP; pfam00672
1423144007723	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1423144007724	dimer interface [polypeptide binding]; other site
1423144007725	phosphorylation site [posttranslational modification]
1423144007726	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1423144007727	ATP binding site [chemical binding]; other site
1423144007728	Mg2+ binding site [ion binding]; other site
1423144007729	G-X-G motif; other site
1423144007730	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1423144007731	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1423144007732	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1423144007733	Walker A/P-loop; other site
1423144007734	ATP binding site [chemical binding]; other site
1423144007735	Q-loop/lid; other site
1423144007736	ABC transporter signature motif; other site
1423144007737	Walker B; other site
1423144007738	D-loop; other site
1423144007739	H-loop/switch region; other site
1423144007740	TOBE domain; Region: TOBE_2; pfam08402
1423144007741	Alpha amylase catalytic domain found in oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase) and related proteins; Region: AmyAc_OligoGlu; cd11330
1423144007742	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
1423144007743	active site
1423144007744	catalytic site [active]
1423144007745	Domain of unknown function (DUF3459); Region: DUF3459; pfam11941
1423144007746	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1423144007747	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144007748	dimer interface [polypeptide binding]; other site
1423144007749	conserved gate region; other site
1423144007750	putative PBP binding loops; other site
1423144007751	ABC-ATPase subunit interface; other site
1423144007752	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1423144007753	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144007754	conserved gate region; other site
1423144007755	dimer interface [polypeptide binding]; other site
1423144007756	putative PBP binding loops; other site
1423144007757	ABC-ATPase subunit interface; other site
1423144007758	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1423144007759	Z1 domain; Region: Z1; pfam10593
1423144007760	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1423144007761	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1423144007762	DNA binding site [nucleotide binding]
1423144007763	domain linker motif; other site
1423144007764	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
1423144007765	ligand binding site [chemical binding]; other site
1423144007766	Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046
1423144007767	beta-galactosidase; Region: BGL; TIGR03356
1423144007768	acetylornithine deacetylase; Provisional; Region: PRK07522
1423144007769	M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894
1423144007770	metal binding site [ion binding]; metal-binding site
1423144007771	putative dimer interface [polypeptide binding]; other site
1423144007772	ectoine utilization protein EutD; Region: ectoine_eutD; TIGR02993
1423144007773	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1423144007774	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
1423144007775	active site
1423144007776	hypothetical protein; Provisional; Region: PRK07482
1423144007777	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1423144007778	inhibitor-cofactor binding pocket; inhibition site
1423144007779	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144007780	catalytic residue [active]
1423144007781	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1423144007782	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1423144007783	DNA binding site [nucleotide binding]
1423144007784	domain linker motif; other site
1423144007785	This group includes the ligand-binding domain of putative DNA transcription repressors which are highly similar to that of the repressor specific for gluconate (GntR), a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR_like_1; cd06273
1423144007786	putative dimerization interface [polypeptide binding]; other site
1423144007787	putative ligand binding site [chemical binding]; other site
1423144007788	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
1423144007789	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
1423144007790	DctM-like transporters; Region: DctM; pfam06808
1423144007791	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
1423144007792	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
1423144007793	histidinol dehydrogenase; Region: hisD; TIGR00069
1423144007794	NAD binding site [chemical binding]; other site
1423144007795	dimerization interface [polypeptide binding]; other site
1423144007796	product binding site; other site
1423144007797	substrate binding site [chemical binding]; other site
1423144007798	zinc binding site [ion binding]; other site
1423144007799	catalytic residues [active]
1423144007800	gluconate 5-dehydrogenase; Provisional; Region: PRK08213
1423144007801	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1423144007802	NAD(P) binding site [chemical binding]; other site
1423144007803	active site
1423144007804	Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063
1423144007805	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1423144007806	NAD(P) binding site [chemical binding]; other site
1423144007807	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1423144007808	Ligand Binding Site [chemical binding]; other site
1423144007809	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1423144007810	PYR/PP interface [polypeptide binding]; other site
1423144007811	dimer interface [polypeptide binding]; other site
1423144007812	TPP binding site [chemical binding]; other site
1423144007813	sulfopyruvate decarboxylase, beta subunit; Region: sulfopy_beta; TIGR03846
1423144007814	Thiamine pyrophosphate (TPP) family, ComE subfamily, TPP-binding module; composed of proteins similar to Methanococcus jannaschii sulfopyruvate decarboxylase beta subunit (ComE). M. jannaschii sulfopyruvate decarboxylase (ComDE) is a dodecamer of six...; Region: TPP_ComE; cd03372
1423144007815	TPP-binding site; other site
1423144007816	FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070
1423144007817	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
1423144007818	active site
1423144007819	substrate binding site [chemical binding]; other site
1423144007820	FMN binding site [chemical binding]; other site
1423144007821	putative catalytic residues [active]
1423144007822	Autoinducer synthetase; Region: Autoind_synth; cl17404
1423144007823	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1423144007824	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1423144007825	dimer interface [polypeptide binding]; other site
1423144007826	phosphorylation site [posttranslational modification]
1423144007827	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1423144007828	ATP binding site [chemical binding]; other site
1423144007829	Mg2+ binding site [ion binding]; other site
1423144007830	G-X-G motif; other site
1423144007831	Response regulator receiver domain; Region: Response_reg; pfam00072
1423144007832	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144007833	active site
1423144007834	phosphorylation site [posttranslational modification]
1423144007835	intermolecular recognition site; other site
1423144007836	dimerization interface [polypeptide binding]; other site
1423144007837	O-acetylhomoserine sulfhydrylase [Amino acid transport and metabolism]; Region: MET17; COG2873
1423144007838	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
1423144007839	homodimer interface [polypeptide binding]; other site
1423144007840	substrate-cofactor binding pocket; other site
1423144007841	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144007842	catalytic residue [active]
1423144007843	Uncharacterized conserved protein [Function unknown]; Region: COG2968
1423144007844	Protein of unknown function (DUF541); Region: SIMPL; pfam04402
1423144007845	type IV pilus biogenesis protein PilP; Region: pilP_fam; TIGR03021
1423144007846	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
1423144007847	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
1423144007848	dimer interface [polypeptide binding]; other site
1423144007849	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
1423144007850	active site
1423144007851	Fe binding site [ion binding]; other site
1423144007852	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1423144007853	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
1423144007854	AsnC family; Region: AsnC_trans_reg; pfam01037
1423144007855	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1423144007856	PAS domain; Region: PAS_9; pfam13426
1423144007857	putative active site [active]
1423144007858	heme pocket [chemical binding]; other site
1423144007859	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
1423144007860	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
1423144007861	TrkA-N domain; Region: TrkA_N; pfam02254
1423144007862	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
1423144007863	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
1423144007864	putative dimer interface [polypeptide binding]; other site
1423144007865	active site pocket [active]
1423144007866	putative cataytic base [active]
1423144007867	cobalamin synthase; Reviewed; Region: cobS; PRK00235
1423144007868	Ion transport protein; Region: Ion_trans; pfam00520
1423144007869	Ion channel; Region: Ion_trans_2; pfam07885
1423144007870	Transcriptional regulators, similar to M. xanthus CarD [Transcription]; Region: COG1329
1423144007871	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
1423144007872	4Fe-4S binding domain; Region: Fer4; pfam00037
1423144007873	Domain of unknown function (DUF3470); Region: DUF3470; pfam11953
1423144007874	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
1423144007875	RNA binding surface [nucleotide binding]; other site
1423144007876	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
1423144007877	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1423144007878	nucleotide binding region [chemical binding]; other site
1423144007879	ATP-binding site [chemical binding]; other site
1423144007880	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1423144007881	binding surface
1423144007882	TPR repeat; Region: TPR_11; pfam13414
1423144007883	TPR motif; other site
1423144007884	TPR repeat; Region: TPR_11; pfam13414
1423144007885	SCP-2 sterol transfer family; Region: SCP2; pfam02036
1423144007886	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1423144007887	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1423144007888	oligoendopeptidase, pepF/M3 family; Region: M3_fam_3; TIGR02290
1423144007889	Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_5; cd09610
1423144007890	active site
1423144007891	Zn binding site [ion binding]; other site
1423144007892	hypothetical protein; Provisional; Region: PRK11019
1423144007893	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1423144007894	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
1423144007895	putative C-terminal domain interface [polypeptide binding]; other site
1423144007896	putative GSH binding site (G-site) [chemical binding]; other site
1423144007897	putative dimer interface [polypeptide binding]; other site
1423144007898	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
1423144007899	dimer interface [polypeptide binding]; other site
1423144007900	N-terminal domain interface [polypeptide binding]; other site
1423144007901	substrate binding pocket (H-site) [chemical binding]; other site
1423144007902	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
1423144007903	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1423144007904	NAD(P) binding site [chemical binding]; other site
1423144007905	putative active site [active]
1423144007906	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1423144007907	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1423144007908	Walker A/P-loop; other site
1423144007909	ATP binding site [chemical binding]; other site
1423144007910	Q-loop/lid; other site
1423144007911	ABC transporter signature motif; other site
1423144007912	Walker B; other site
1423144007913	D-loop; other site
1423144007914	H-loop/switch region; other site
1423144007915	TOBE domain; Region: TOBE_2; pfam08402
1423144007916	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1423144007917	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
1423144007918	Bacterial transcriptional regulator; Region: IclR; pfam01614
1423144007919	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1423144007920	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1423144007921	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1423144007922	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144007923	dimer interface [polypeptide binding]; other site
1423144007924	conserved gate region; other site
1423144007925	putative PBP binding loops; other site
1423144007926	ABC-ATPase subunit interface; other site
1423144007927	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1423144007928	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144007929	dimer interface [polypeptide binding]; other site
1423144007930	conserved gate region; other site
1423144007931	putative PBP binding loops; other site
1423144007932	ABC-ATPase subunit interface; other site
1423144007933	Alpha-galactosidase [Carbohydrate transport and metabolism]; Region: GalA; COG3345
1423144007934	Melibiase; Region: Melibiase; pfam02065
1423144007935	dihydroxy-acid dehydratase; Validated; Region: PRK06131
1423144007936	Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028
1423144007937	classical (c) SDRs; Region: SDR_c; cd05233
1423144007938	NAD(P) binding site [chemical binding]; other site
1423144007939	active site
1423144007940	2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734
1423144007941	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
1423144007942	2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140
1423144007943	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
1423144007944	active site
1423144007945	intersubunit interface [polypeptide binding]; other site
1423144007946	catalytic residue [active]
1423144007947	SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450
1423144007948	Beta-galactosidase [Carbohydrate transport and metabolism]; Region: LacA; COG1874
1423144007949	Beta-galactosidase; Region: Glyco_hydro_42; pfam02449
1423144007950	A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143
1423144007951	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1423144007952	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1423144007953	Walker A/P-loop; other site
1423144007954	ATP binding site [chemical binding]; other site
1423144007955	Q-loop/lid; other site
1423144007956	ABC transporter signature motif; other site
1423144007957	Walker B; other site
1423144007958	D-loop; other site
1423144007959	H-loop/switch region; other site
1423144007960	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1423144007961	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1423144007962	TM-ABC transporter signature motif; other site
1423144007963	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1423144007964	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
1423144007965	putative ligand binding site [chemical binding]; other site
1423144007966	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1423144007967	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1423144007968	DNA binding site [nucleotide binding]
1423144007969	domain linker motif; other site
1423144007970	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278
1423144007971	putative dimerization interface [polypeptide binding]; other site
1423144007972	putative ligand binding site [chemical binding]; other site
1423144007973	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1423144007974	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1423144007975	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1423144007976	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1423144007977	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1423144007978	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1423144007979	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1423144007980	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
1423144007981	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1423144007982	dimer interface [polypeptide binding]; other site
1423144007983	PYR/PP interface [polypeptide binding]; other site
1423144007984	TPP binding site [chemical binding]; other site
1423144007985	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1423144007986	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1423144007987	TPP-binding site [chemical binding]; other site
1423144007988	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1423144007989	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1423144007990	substrate binding site [chemical binding]; other site
1423144007991	ATP binding site [chemical binding]; other site
1423144007992	KduI/IolB family; Region: KduI; pfam04962
1423144007993	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
1423144007994	intersubunit interface [polypeptide binding]; other site
1423144007995	active site
1423144007996	zinc binding site [ion binding]; other site
1423144007997	Na+ binding site [ion binding]; other site
1423144007998	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1423144007999	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1423144008000	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1423144008001	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
1423144008002	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
1423144008003	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1423144008004	DNA binding site [nucleotide binding]
1423144008005	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1423144008006	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1423144008007	NAD binding domain of 6-phosphogluconate dehydrogenase; Region: NAD_binding_2; pfam03446
1423144008008	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1423144008009	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1423144008010	Bacterial transcriptional regulator; Region: IclR; pfam01614
1423144008011	56kDa selenium binding protein (SBP56); Region: SBP56; pfam05694
1423144008012	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
1423144008013	Cu(I) binding site [ion binding]; other site
1423144008014	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
1423144008015	Domain of unknown function (DUF1924); Region: DUF1924; pfam09086
1423144008016	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1423144008017	Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412
1423144008018	putative DNA binding site [nucleotide binding]; other site
1423144008019	putative Zn2+ binding site [ion binding]; other site
1423144008020	AsnC family; Region: AsnC_trans_reg; pfam01037
1423144008021	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1423144008022	Ligand Binding Site [chemical binding]; other site
1423144008023	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1423144008024	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
1423144008025	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
1423144008026	Hint domain; Region: Hint_2; pfam13403
1423144008027	large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952
1423144008028	large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567
1423144008029	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1423144008030	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
1423144008031	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
1423144008032	Protein of unknown function (DUF2872); Region: DUF2872; pfam11071
1423144008033	Methyltransferase domain; Region: Methyltransf_23; pfam13489
1423144008034	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1423144008035	S-adenosylmethionine binding site [chemical binding]; other site
1423144008036	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1423144008037	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144008038	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1423144008039	dimerization interface [polypeptide binding]; other site
1423144008040	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
1423144008041	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
1423144008042	putative tRNA-binding site [nucleotide binding]; other site
1423144008043	B3/4 domain; Region: B3_4; pfam03483
1423144008044	tRNA synthetase B5 domain; Region: B5; smart00874
1423144008045	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
1423144008046	dimer interface [polypeptide binding]; other site
1423144008047	motif 1; other site
1423144008048	motif 3; other site
1423144008049	motif 2; other site
1423144008050	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; smart00896
1423144008051	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
1423144008052	linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073
1423144008053	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
1423144008054	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
1423144008055	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
1423144008056	dimer interface [polypeptide binding]; other site
1423144008057	motif 1; other site
1423144008058	active site
1423144008059	motif 2; other site
1423144008060	motif 3; other site
1423144008061	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
1423144008062	23S rRNA binding site [nucleotide binding]; other site
1423144008063	L21 binding site [polypeptide binding]; other site
1423144008064	L13 binding site [polypeptide binding]; other site
1423144008065	50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172
1423144008066	pyruvate kinase; Provisional; Region: PRK06247
1423144008067	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
1423144008068	domain interfaces; other site
1423144008069	active site
1423144008070	Protein of unknown function (DUF1244); Region: DUF1244; pfam06844
1423144008071	Protein of unknown function (DUF1489); Region: DUF1489; pfam07370
1423144008072	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
1423144008073	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
1423144008074	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
1423144008075	active site
1423144008076	dimer interface [polypeptide binding]; other site
1423144008077	effector binding site; other site
1423144008078	TSCPD domain; Region: TSCPD; pfam12637
1423144008079	Aquifex aeolicus AQ1575 and related proteins, metallophosphatase domain; Region: MPP_AQ1575; cd07390
1423144008080	putative active site [active]
1423144008081	putative metal binding site [ion binding]; other site
1423144008082	Integrase core domain; Region: rve; pfam00665
1423144008083	Transposase; Region: HTH_Tnp_1; cl17663
1423144008084	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
1423144008085	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
1423144008086	homotrimer interaction site [polypeptide binding]; other site
1423144008087	putative active site [active]
1423144008088	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
1423144008089	D-cysteine desulfhydrase; Validated; Region: PRK03910
1423144008090	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
1423144008091	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1423144008092	catalytic residue [active]
1423144008093	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144008094	transcriptional regulator, ArgP family; Region: argP; TIGR03298
1423144008095	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1423144008096	dimerization interface [polypeptide binding]; other site
1423144008097	cell density-dependent motility repressor; Provisional; Region: PRK10082
1423144008098	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144008099	LysR substrate binding domain; Region: LysR_substrate; pfam03466
1423144008100	dimerization interface [polypeptide binding]; other site
1423144008101	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1423144008102	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
1423144008103	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290
1423144008104	DctM-like transporters; Region: DctM; pfam06808
1423144008105	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
1423144008106	PGAP1-like protein; Region: PGAP1; pfam07819
1423144008107	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1423144008108	Sel1-like repeats; Region: SEL1; smart00671
1423144008109	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1423144008110	Sel1-like repeats; Region: SEL1; smart00671
1423144008111	Sel1-like repeats; Region: SEL1; smart00671
1423144008112	Sel1-like repeats; Region: SEL1; smart00671
1423144008113	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
1423144008114	an uncharacterized bacterial subgroup of the DEDDh 3'-5' exonuclease domain family with similarity to the epsilon subunit of DNA polymerase III; Region: DNA_pol_III_epsilon_like; cd06130
1423144008115	active site
1423144008116	catalytic site [active]
1423144008117	substrate binding site [chemical binding]; other site
1423144008118	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1423144008119	EamA-like transporter family; Region: EamA; pfam00892
1423144008120	nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790
1423144008121	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144008122	dimer interface [polypeptide binding]; other site
1423144008123	conserved gate region; other site
1423144008124	putative PBP binding loops; other site
1423144008125	ABC-ATPase subunit interface; other site
1423144008126	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1423144008127	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144008128	dimer interface [polypeptide binding]; other site
1423144008129	conserved gate region; other site
1423144008130	putative PBP binding loops; other site
1423144008131	ABC-ATPase subunit interface; other site
1423144008132	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1423144008133	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1423144008134	Walker A/P-loop; other site
1423144008135	ATP binding site [chemical binding]; other site
1423144008136	Q-loop/lid; other site
1423144008137	ABC transporter signature motif; other site
1423144008138	Walker B; other site
1423144008139	D-loop; other site
1423144008140	H-loop/switch region; other site
1423144008141	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124
1423144008142	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1423144008143	Walker A/P-loop; other site
1423144008144	ATP binding site [chemical binding]; other site
1423144008145	Q-loop/lid; other site
1423144008146	ABC transporter signature motif; other site
1423144008147	Walker B; other site
1423144008148	D-loop; other site
1423144008149	H-loop/switch region; other site
1423144008150	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1423144008151	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1423144008152	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_3; cd08490
1423144008153	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1423144008154	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144008155	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1423144008156	dimerization interface [polypeptide binding]; other site
1423144008157	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
1423144008158	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1423144008159	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144008160	homodimer interface [polypeptide binding]; other site
1423144008161	catalytic residue [active]
1423144008162	Membrane transport protein; Region: Mem_trans; cl09117
1423144008163	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1423144008164	lipoate-protein ligase B; Provisional; Region: PRK14341
1423144008165	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
1423144008166	HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277
1423144008167	HIT family signature motif; other site
1423144008168	catalytic residue [active]
1423144008169	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
1423144008170	Subunit I/III interface [polypeptide binding]; other site
1423144008171	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
1423144008172	D-pathway; other site
1423144008173	Subunit I/VIIc interface [polypeptide binding]; other site
1423144008174	Subunit I/IV interface [polypeptide binding]; other site
1423144008175	Subunit I/II interface [polypeptide binding]; other site
1423144008176	Low-spin heme (heme a) binding site [chemical binding]; other site
1423144008177	Subunit I/VIIa interface [polypeptide binding]; other site
1423144008178	Subunit I/VIa interface [polypeptide binding]; other site
1423144008179	Dimer interface; other site
1423144008180	Putative water exit pathway; other site
1423144008181	Binuclear center (heme a3/CuB) [ion binding]; other site
1423144008182	K-pathway; other site
1423144008183	Subunit I/Vb interface [polypeptide binding]; other site
1423144008184	Putative proton exit pathway; other site
1423144008185	Subunit I/VIb interface; other site
1423144008186	Subunit I/VIc interface [polypeptide binding]; other site
1423144008187	Electron transfer pathway; other site
1423144008188	Subunit I/VIIIb interface [polypeptide binding]; other site
1423144008189	Subunit I/VIIb interface [polypeptide binding]; other site
1423144008190	Integral membrane protein (DUF2244); Region: DUF2244; pfam10003
1423144008191	Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287
1423144008192	arogenate dehydrogenase; Region: PLN02256
1423144008193	Yqey-like protein; Region: YqeY; pfam09424
1423144008194	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
1423144008195	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988
1423144008196	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
1423144008197	catalytic site [active]
1423144008198	subunit interface [polypeptide binding]; other site
1423144008199	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
1423144008200	CESA_like_2 is a member of the cellulose synthase superfamily; Region: CESA_like_2; cd06427
1423144008201	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1423144008202	DXD motif; other site
1423144008203	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1423144008204	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1423144008205	DNA-binding site [nucleotide binding]; DNA binding site
1423144008206	FCD domain; Region: FCD; pfam07729
1423144008207	pyrimidine 5'-nucleotidase; Region: Pyr-5-nucltdase; TIGR01993
1423144008208	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1423144008209	motif II; other site
1423144008210	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07494
1423144008211	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1423144008212	Peptidase M50B-like; Region: Peptidase_M50B; pfam13398
1423144008213	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1423144008214	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1423144008215	putative DNA binding site [nucleotide binding]; other site
1423144008216	putative Zn2+ binding site [ion binding]; other site
1423144008217	AsnC family; Region: AsnC_trans_reg; pfam01037
1423144008218	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1423144008219	AsnC family; Region: AsnC_trans_reg; pfam01037
1423144008220	ketol-acid reductoisomerase; Provisional; Region: PRK05479
1423144008221	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
1423144008222	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
1423144008223	EamA-like transporter family; Region: EamA; pfam00892
1423144008224	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1423144008225	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1423144008226	EamA-like transporter family; Region: EamA; pfam00892
1423144008227	EamA-like transporter family; Region: EamA; pfam00892
1423144008228	phosphoglucosamine mutase; Provisional; Region: glmM; PRK14315
1423144008229	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
1423144008230	active site
1423144008231	substrate binding site [chemical binding]; other site
1423144008232	metal binding site [ion binding]; metal-binding site
1423144008233	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
1423144008234	dihydropteroate synthase; Region: DHPS; TIGR01496
1423144008235	substrate binding pocket [chemical binding]; other site
1423144008236	dimer interface [polypeptide binding]; other site
1423144008237	inhibitor binding site; inhibition site
1423144008238	Dihydroneopterin aldolase; Region: FolB; smart00905
1423144008239	active site
1423144008240	Cell Wall Hydrolase; Region: Hydrolase_2; pfam07486
1423144008241	pyruvate phosphate dikinase; Provisional; Region: PRK09279
1423144008242	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1423144008243	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1423144008244	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
1423144008245	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
1423144008246	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
1423144008247	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
1423144008248	glycyl-tRNA synthetase subunit alpha; Validated; Region: glyQ; PRK09348
1423144008249	motif 1; other site
1423144008250	dimer interface [polypeptide binding]; other site
1423144008251	active site
1423144008252	motif 2; other site
1423144008253	motif 3; other site
1423144008254	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1423144008255	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
1423144008256	C factor cell-cell signaling protein; Provisional; Region: PRK09009
1423144008257	carbonyl reductase sniffer-like, classical (c) SDRs; Region: carb_red_sniffer_like_SDR_c; cd05325
1423144008258	NADP binding site [chemical binding]; other site
1423144008259	homodimer interface [polypeptide binding]; other site
1423144008260	active site
1423144008261	Protein of unknown function (DUF1178); Region: DUF1178; pfam06676
1423144008262	EcsC protein family; Region: EcsC; pfam12787
1423144008263	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1423144008264	Coenzyme A binding pocket [chemical binding]; other site
1423144008265	Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853
1423144008266	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
1423144008267	trimer interface [polypeptide binding]; other site
1423144008268	active site
1423144008269	substrate binding site [chemical binding]; other site
1423144008270	CoA binding site [chemical binding]; other site
1423144008271	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
1423144008272	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
1423144008273	Sulfate transporter family; Region: Sulfate_transp; pfam00916
1423144008274	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
1423144008275	5'-methylthioadenosine phosphorylase; Provisional; Region: PRK08931
1423144008276	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1423144008277	active site
1423144008278	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
1423144008279	Fasciclin domain; Region: Fasciclin; pfam02469
1423144008280	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1423144008281	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1423144008282	putative substrate translocation pore; other site
1423144008283	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
1423144008284	FAD binding domain; Region: FAD_binding_4; pfam01565
1423144008285	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
1423144008286	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
1423144008287	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1423144008288	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1423144008289	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1423144008290	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
1423144008291	Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560
1423144008292	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144008293	catalytic residue [active]
1423144008294	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
1423144008295	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
1423144008296	Subunit III/VIIa interface [polypeptide binding]; other site
1423144008297	Phospholipid binding site [chemical binding]; other site
1423144008298	Subunit I/III interface [polypeptide binding]; other site
1423144008299	Subunit III/VIb interface [polypeptide binding]; other site
1423144008300	Subunit III/VIa interface; other site
1423144008301	Subunit III/Vb interface [polypeptide binding]; other site
1423144008302	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
1423144008303	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
1423144008304	UbiA prenyltransferase family; Region: UbiA; pfam01040
1423144008305	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
1423144008306	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
1423144008307	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
1423144008308	protease TldD; Provisional; Region: tldD; PRK10735
1423144008309	Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758
1423144008310	DNA protecting protein DprA; Region: dprA; TIGR00732
1423144008311	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
1423144008312	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
1423144008313	active site
1423144008314	interdomain interaction site; other site
1423144008315	putative metal-binding site [ion binding]; other site
1423144008316	nucleotide binding site [chemical binding]; other site
1423144008317	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
1423144008318	domain I; other site
1423144008319	DNA binding groove [nucleotide binding]
1423144008320	phosphate binding site [ion binding]; other site
1423144008321	domain II; other site
1423144008322	domain III; other site
1423144008323	nucleotide binding site [chemical binding]; other site
1423144008324	catalytic site [active]
1423144008325	domain IV; other site
1423144008326	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
1423144008327	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1423144008328	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1423144008329	Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368
1423144008330	Acyl CoA:acetate/3-ketoacid CoA transferase, alpha subunit [Lipid metabolism]; Region: AtoD; COG1788
1423144008331	3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428
1423144008332	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1423144008333	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1423144008334	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1423144008335	catalytic residue [active]
1423144008336	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
1423144008337	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
1423144008338	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
1423144008339	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
1423144008340	BON domain; Region: BON; pfam04972
1423144008341	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
1423144008342	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1423144008343	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1423144008344	ligand binding site [chemical binding]; other site
1423144008345	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1423144008346	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
1423144008347	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1423144008348	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
1423144008349	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
1423144008350	ATP binding site [chemical binding]; other site
1423144008351	Walker A motif; other site
1423144008352	hexamer interface [polypeptide binding]; other site
1423144008353	Walker B motif; other site
1423144008354	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
1423144008355	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1423144008356	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
1423144008357	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
1423144008358	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1423144008359	TPR motif; other site
1423144008360	binding surface
1423144008361	TPR repeat; Region: TPR_11; pfam13414
1423144008362	putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917
1423144008363	Flp pilus assembly protein TadD, contains TPR repeats [Intracellular trafficking and secretion]; Region: TadD; COG5010
1423144008364	DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153
1423144008365	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
1423144008366	RNA helicase; Region: RNA_helicase; pfam00910
1423144008367	DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121
1423144008368	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1423144008369	ATP binding site [chemical binding]; other site
1423144008370	putative Mg++ binding site [ion binding]; other site
1423144008371	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
1423144008372	nucleotide binding region [chemical binding]; other site
1423144008373	ATP-binding site [chemical binding]; other site
1423144008374	DEAD/H associated; Region: DEAD_assoc; pfam08494
1423144008375	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1423144008376	Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391
1423144008377	putative active site [active]
1423144008378	putative metal binding site [ion binding]; other site
1423144008379	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1423144008380	CoenzymeA binding site [chemical binding]; other site
1423144008381	subunit interaction site [polypeptide binding]; other site
1423144008382	PHB binding site; other site
1423144008383	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14188
1423144008384	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
1423144008385	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
1423144008386	homodimer interface [polypeptide binding]; other site
1423144008387	NADP binding site [chemical binding]; other site
1423144008388	substrate binding site [chemical binding]; other site
1423144008389	Chorismate mutase type II; Region: CM_2; smart00830
1423144008390	formate--tetrahydrofolate ligase; Provisional; Region: PRK13505
1423144008391	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
1423144008392	Potassium binding sites [ion binding]; other site
1423144008393	Cesium cation binding sites [ion binding]; other site
1423144008394	MOSC domain; Region: MOSC; pfam03473
1423144008395	FtsH Extracellular; Region: FtsH_ext; pfam06480
1423144008396	ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241
1423144008397	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1423144008398	Walker A motif; other site
1423144008399	ATP binding site [chemical binding]; other site
1423144008400	Walker B motif; other site
1423144008401	arginine finger; other site
1423144008402	Peptidase family M41; Region: Peptidase_M41; pfam01434
1423144008403	tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037
1423144008404	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
1423144008405	Ligand Binding Site [chemical binding]; other site
1423144008406	tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795
1423144008407	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1423144008408	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1423144008409	ligand binding site [chemical binding]; other site
1423144008410	translocation protein TolB; Provisional; Region: tolB; PRK05137
1423144008411	TolB amino-terminal domain; Region: TolB_N; pfam04052
1423144008412	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1423144008413	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1423144008414	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1423144008415	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1423144008416	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
1423144008417	TolR protein; Region: tolR; TIGR02801
1423144008418	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1423144008419	TolQ protein; Region: tolQ; TIGR02796
1423144008420	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1423144008421	active site
1423144008422	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
1423144008423	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1423144008424	Walker A motif; other site
1423144008425	ATP binding site [chemical binding]; other site
1423144008426	Walker B motif; other site
1423144008427	arginine finger; other site
1423144008428	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
1423144008429	Holliday junction DNA helicase RuvA; Provisional; Region: ruvA; PRK14604
1423144008430	RuvA N terminal domain; Region: RuvA_N; pfam01330
1423144008431	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
1423144008432	active site
1423144008433	putative DNA-binding cleft [nucleotide binding]; other site
1423144008434	dimer interface [polypeptide binding]; other site
1423144008435	Domain of unknown function (DUF1127); Region: DUF1127; pfam06568
1423144008436	Ribosomal protein L11 methylase [Translation, ribosomal structure and biogenesis]; Region: PrmA; COG2264
1423144008437	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1423144008438	S-adenosylmethionine binding site [chemical binding]; other site
1423144008439	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
1423144008440	primosome assembly protein PriA; Validated; Region: PRK05580
1423144008441	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1423144008442	ATP binding site [chemical binding]; other site
1423144008443	putative Mg++ binding site [ion binding]; other site
1423144008444	Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956
1423144008445	active site
1423144008446	intersubunit interactions; other site
1423144008447	catalytic residue [active]
1423144008448	Protein of unknown function, DUF484; Region: DUF484; cl17449
1423144008449	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
1423144008450	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1423144008451	active site
1423144008452	DNA binding site [nucleotide binding]
1423144008453	Int/Topo IB signature motif; other site
1423144008454	Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183
1423144008455	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
1423144008456	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1423144008457	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1423144008458	DNA binding site [nucleotide binding]
1423144008459	active site
1423144008460	isoleucyl-tRNA synthetase; Provisional; Region: ileS; PRK13804
1423144008461	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1423144008462	active site
1423144008463	HIGH motif; other site
1423144008464	nucleotide binding site [chemical binding]; other site
1423144008465	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
1423144008466	active site
1423144008467	KMSKS motif; other site
1423144008468	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
1423144008469	tRNA binding surface [nucleotide binding]; other site
1423144008470	anticodon binding site; other site
1423144008471	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1423144008472	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1423144008473	Pentapeptide repeats containing protein [Function unknown]; Region: COG1357
1423144008474	Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805
1423144008475	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
1423144008476	heme-binding site [chemical binding]; other site
1423144008477	hypothetical protein; Provisional; Region: PRK05415
1423144008478	Domain of unknown function (DUF697); Region: DUF697; pfam05128
1423144008479	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
1423144008480	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1423144008481	Coenzyme A binding pocket [chemical binding]; other site
1423144008482	YcjX-like family, DUF463; Region: DUF463; pfam04317
1423144008483	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
1423144008484	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
1423144008485	dimerization interface 3.5A [polypeptide binding]; other site
1423144008486	active site
1423144008487	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459
1423144008488	PAS domain; Region: PAS_9; pfam13426
1423144008489	putative active site [active]
1423144008490	heme pocket [chemical binding]; other site
1423144008491	7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258
1423144008492	7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: Bsubt_queE; TIGR03365
1423144008493	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
1423144008494	6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720
1423144008495	active site
1423144008496	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
1423144008497	Ligand Binding Site [chemical binding]; other site
1423144008498	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1423144008499	Acyl-CoA dehydrogenases similar to fadE2; Region: ACAD_FadE2; cd01155
1423144008500	FAD binding site [chemical binding]; other site
1423144008501	substrate binding site [chemical binding]; other site
1423144008502	catalytic base [active]
1423144008503	glycine dehydrogenase; Provisional; Region: PRK05367
1423144008504	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1423144008505	tetramer interface [polypeptide binding]; other site
1423144008506	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144008507	catalytic residue [active]
1423144008508	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1423144008509	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144008510	tetramer interface [polypeptide binding]; other site
1423144008511	catalytic residue [active]
1423144008512	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1423144008513	lipoyl attachment site [posttranslational modification]; other site
1423144008514	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
1423144008515	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
1423144008516	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
1423144008517	beta-ketoadipate pathway transcriptional regulators, PcaR/PcaU/PobR family; Region: pcaR_pcaU; TIGR02431
1423144008518	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1423144008519	Bacterial transcriptional regulator; Region: IclR; pfam01614
1423144008520	hypothetical protein; Provisional; Region: PRK11171
1423144008521	Cupin domain; Region: Cupin_2; pfam07883
1423144008522	Cupin domain; Region: Cupin_2; pfam07883
1423144008523	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
1423144008524	glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534
1423144008525	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
1423144008526	xanthine permease; Region: pbuX; TIGR03173
1423144008527	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
1423144008528	Ureidoglycolate hydrolase; Region: Ureidogly_hydro; pfam04115
1423144008529	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
1423144008530	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
1423144008531	active site
1423144008532	catalytic site [active]
1423144008533	tetramer interface [polypeptide binding]; other site
1423144008534	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3195
1423144008535	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
1423144008536	active site
1423144008537	homotetramer interface [polypeptide binding]; other site
1423144008538	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1423144008539	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144008540	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1423144008541	dimerization interface [polypeptide binding]; other site
1423144008542	putative effector binding pocket; other site
1423144008543	Protein of unknown function (DUF989); Region: DUF989; pfam06181
1423144008544	Predicted membrane protein [Function unknown]; Region: COG3748
1423144008545	Cytochrome c; Region: Cytochrom_C; pfam00034
1423144008546	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
1423144008547	Surface antigen; Region: Bac_surface_Ag; pfam01103
1423144008548	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
1423144008549	Family of unknown function (DUF490); Region: DUF490; pfam04357
1423144008550	Glucokinase; Region: Glucokinase; cl17310
1423144008551	glucokinase, proteobacterial type; Region: glk; TIGR00749
1423144008552	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
1423144008553	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1423144008554	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1423144008555	active site
1423144008556	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
1423144008557	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
1423144008558	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
1423144008559	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
1423144008560	active site
1423144008561	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
1423144008562	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
1423144008563	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
1423144008564	putative NADP binding site [chemical binding]; other site
1423144008565	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
1423144008566	active site
1423144008567	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
1423144008568	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1423144008569	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
1423144008570	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1423144008571	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186
1423144008572	Probable Catalytic site; other site
1423144008573	metal-binding site
1423144008574	Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223
1423144008575	Formyltransferase, catalytic core domain; Region: FMT_core; cl00395
1423144008576	active site
1423144008577	substrate binding site [chemical binding]; other site
1423144008578	cosubstrate binding site; other site
1423144008579	catalytic site [active]
1423144008580	C-terminal subdomain of the Formyltransferase-like domain found in OzmH-like proteins; Region: FMT_C_OzmH_like; cd08700
1423144008581	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1423144008582	acyl-activating enzyme (AAE) consensus motif; other site
1423144008583	natural product biosynthesis luciferase-like monooxygenase domain; Region: seco_metab_LLM; TIGR04020
1423144008584	probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858
1423144008585	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
1423144008586	AMP binding site [chemical binding]; other site
1423144008587	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1423144008588	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
1423144008589	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
1423144008590	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1423144008591	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1423144008592	active site
1423144008593	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
1423144008594	putative ADP-binding pocket [chemical binding]; other site
1423144008595	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1423144008596	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
1423144008597	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1423144008598	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
1423144008599	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
1423144008600	exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018
1423144008601	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
1423144008602	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1423144008603	2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035
1423144008604	Predicted N6-adenine-specific DNA methylase [DNA replication, recombination, and repair]; Region: COG0116
1423144008605	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
1423144008606	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1423144008607	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1423144008608	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1423144008609	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1423144008610	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
1423144008611	Walker A/P-loop; other site
1423144008612	ATP binding site [chemical binding]; other site
1423144008613	Q-loop/lid; other site
1423144008614	ABC transporter signature motif; other site
1423144008615	Walker B; other site
1423144008616	D-loop; other site
1423144008617	H-loop/switch region; other site
1423144008618	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1423144008619	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
1423144008620	Walker A/P-loop; other site
1423144008621	ATP binding site [chemical binding]; other site
1423144008622	Q-loop/lid; other site
1423144008623	ABC transporter signature motif; other site
1423144008624	Walker B; other site
1423144008625	D-loop; other site
1423144008626	H-loop/switch region; other site
1423144008627	TOBE domain; Region: TOBE_2; pfam08402
1423144008628	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144008629	dimer interface [polypeptide binding]; other site
1423144008630	conserved gate region; other site
1423144008631	putative PBP binding loops; other site
1423144008632	ABC-ATPase subunit interface; other site
1423144008633	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1423144008634	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1423144008635	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144008636	dimer interface [polypeptide binding]; other site
1423144008637	conserved gate region; other site
1423144008638	ABC-ATPase subunit interface; other site
1423144008639	Predicted small integral membrane protein (DUF2160); Region: DUF2160; pfam09928
1423144008640	Penicillinase repressor; Region: Pencillinase_R; pfam03965
1423144008641	BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569
1423144008642	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1423144008643	dimerization interface [polypeptide binding]; other site
1423144008644	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1423144008645	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1423144008646	dimer interface [polypeptide binding]; other site
1423144008647	putative CheW interface [polypeptide binding]; other site
1423144008648	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1423144008649	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1423144008650	Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097
1423144008651	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1423144008652	NAD(P) binding site [chemical binding]; other site
1423144008653	catalytic residues [active]
1423144008654	Proline racemase; Region: Pro_racemase; pfam05544
1423144008655	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
1423144008656	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1423144008657	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1423144008658	inhibitor site; inhibition site
1423144008659	active site
1423144008660	dimer interface [polypeptide binding]; other site
1423144008661	catalytic residue [active]
1423144008662	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1423144008663	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1423144008664	DNA-binding site [nucleotide binding]; DNA binding site
1423144008665	FCD domain; Region: FCD; pfam07729
1423144008666	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1423144008667	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1423144008668	active site
1423144008669	WxcM-like, C-terminal; Region: FdtA; pfam05523
1423144008670	DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041
1423144008671	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
1423144008672	inhibitor-cofactor binding pocket; inhibition site
1423144008673	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144008674	catalytic residue [active]
1423144008675	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1423144008676	classical (c) SDRs; Region: SDR_c; cd05233
1423144008677	NAD(P) binding site [chemical binding]; other site
1423144008678	active site
1423144008679	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
1423144008680	active site
1423144008681	GTP-binding protein YchF; Reviewed; Region: PRK09601
1423144008682	YchF GTPase; Region: YchF; cd01900
1423144008683	G1 box; other site
1423144008684	GTP/Mg2+ binding site [chemical binding]; other site
1423144008685	Switch I region; other site
1423144008686	G2 box; other site
1423144008687	Switch II region; other site
1423144008688	G3 box; other site
1423144008689	G4 box; other site
1423144008690	G5 box; other site
1423144008691	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
1423144008692	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
1423144008693	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
1423144008694	substrate binding site [chemical binding]; other site
1423144008695	active site
1423144008696	catalytic residues [active]
1423144008697	heterodimer interface [polypeptide binding]; other site
1423144008698	L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197
1423144008699	Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809
1423144008700	active site
1423144008701	substrate binding site [chemical binding]; other site
1423144008702	FMN binding site [chemical binding]; other site
1423144008703	putative catalytic residues [active]
1423144008704	50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618
1423144008705	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
1423144008706	5S rRNA interface [nucleotide binding]; other site
1423144008707	CTC domain interface [polypeptide binding]; other site
1423144008708	L16 interface [polypeptide binding]; other site
1423144008709	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
1423144008710	putative active site [active]
1423144008711	catalytic residue [active]
1423144008712	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
1423144008713	Beta-lactamase; Region: Beta-lactamase; pfam00144
1423144008714	Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996
1423144008715	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
1423144008716	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
1423144008717	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144008718	catalytic residue [active]
1423144008719	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
1423144008720	active site
1423144008721	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1423144008722	IHF dimer interface [polypeptide binding]; other site
1423144008723	IHF - DNA interface [nucleotide binding]; other site
1423144008724	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
1423144008725	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
1423144008726	RNA binding site [nucleotide binding]; other site
1423144008727	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
1423144008728	RNA binding site [nucleotide binding]; other site
1423144008729	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
1423144008730	RNA binding site [nucleotide binding]; other site
1423144008731	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1423144008732	RNA binding site [nucleotide binding]; other site
1423144008733	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1423144008734	RNA binding site [nucleotide binding]; other site
1423144008735	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
1423144008736	RNA binding site [nucleotide binding]; other site
1423144008737	cytidylate kinase; Provisional; Region: cmk; PRK00023
1423144008738	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
1423144008739	CMP-binding site; other site
1423144008740	The sites determining sugar specificity; other site
1423144008741	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
1423144008742	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
1423144008743	hinge; other site
1423144008744	active site
1423144008745	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
1423144008746	Predicted periplasmic protein [Function unknown]; Region: COG3904
1423144008747	S-adenosylmethionine synthetase; Validated; Region: PRK05250
1423144008748	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
1423144008749	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
1423144008750	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
1423144008751	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
1423144008752	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
1423144008753	putative active site [active]
1423144008754	catalytic triad [active]
1423144008755	putative dimer interface [polypeptide binding]; other site
1423144008756	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
1423144008757	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
1423144008758	Transporter associated domain; Region: CorC_HlyC; smart01091
1423144008759	Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130
1423144008760	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
1423144008761	PhoH-like protein; Region: PhoH; pfam02562
1423144008762	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1423144008763	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1423144008764	ligand binding site [chemical binding]; other site
1423144008765	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
1423144008766	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1423144008767	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1423144008768	FeS/SAM binding site; other site
1423144008769	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
1423144008770	Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312
1423144008771	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1423144008772	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1423144008773	dimerization interface [polypeptide binding]; other site
1423144008774	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1423144008775	metal binding site 2 [ion binding]; metal-binding site
1423144008776	putative DNA binding helix; other site
1423144008777	metal binding site 1 [ion binding]; metal-binding site
1423144008778	dimer interface [polypeptide binding]; other site
1423144008779	structural Zn2+ binding site [ion binding]; other site
1423144008780	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
1423144008781	active site 1 [active]
1423144008782	dimer interface [polypeptide binding]; other site
1423144008783	active site 2 [active]
1423144008784	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
1423144008785	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
1423144008786	dimer interface [polypeptide binding]; other site
1423144008787	active site
1423144008788	Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623
1423144008789	Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372
1423144008790	NAD binding site [chemical binding]; other site
1423144008791	homotetramer interface [polypeptide binding]; other site
1423144008792	homodimer interface [polypeptide binding]; other site
1423144008793	substrate binding site [chemical binding]; other site
1423144008794	active site
1423144008795	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
1423144008796	2-Nitropropane dioxygenase (NPD), one of the nitroalkane oxidizing enzyme families, catalyzes oxidative denitrification of nitroalkanes to their corresponding carbonyl compounds and nitrites. NDP is a member of the NAD(P)H-dependent flavin oxidoreductase...; Region: NPD_like; cd04730
1423144008797	FMN binding site [chemical binding]; other site
1423144008798	substrate binding site [chemical binding]; other site
1423144008799	putative catalytic residue [active]
1423144008800	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
1423144008801	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
1423144008802	2-haloalkanoic acid dehalogenase, type II; Region: HAD_type_II; TIGR01428
1423144008803	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1423144008804	motif II; other site
1423144008805	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1423144008806	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
1423144008807	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1423144008808	tetramer interface [polypeptide binding]; other site
1423144008809	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144008810	catalytic residue [active]
1423144008811	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1423144008812	putative catalytic site [active]
1423144008813	putative metal binding site [ion binding]; other site
1423144008814	putative phosphate binding site [ion binding]; other site
1423144008815	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
1423144008816	prokaryotic 3-carboxy-cis,cis-muconate cycloisomerase (CMLE)_like; Region: pCLME; cd01597
1423144008817	Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015
1423144008818	tetramer interface [polypeptide binding]; other site
1423144008819	active site
1423144008820	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
1423144008821	Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279
1423144008822	NAD binding site [chemical binding]; other site
1423144008823	catalytic Zn binding site [ion binding]; other site
1423144008824	substrate binding site [chemical binding]; other site
1423144008825	structural Zn binding site [ion binding]; other site
1423144008826	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1423144008827	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
1423144008828	active site pocket [active]
1423144008829	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1423144008830	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1423144008831	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1423144008832	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1423144008833	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
1423144008834	Walker A/P-loop; other site
1423144008835	ATP binding site [chemical binding]; other site
1423144008836	Q-loop/lid; other site
1423144008837	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1423144008838	Walker B; other site
1423144008839	D-loop; other site
1423144008840	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1423144008841	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1423144008842	ligand binding site [chemical binding]; other site
1423144008843	flexible hinge region; other site
1423144008844	Protein of unknown function (DUF3307); Region: DUF3307; pfam11750
1423144008845	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1423144008846	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1423144008847	putative DNA binding site [nucleotide binding]; other site
1423144008848	putative Zn2+ binding site [ion binding]; other site
1423144008849	AsnC family; Region: AsnC_trans_reg; pfam01037
1423144008850	2-oxoacid ferredoxin oxidoreductase; Provisional; Region: PRK13030
1423144008851	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
1423144008852	dimer interface [polypeptide binding]; other site
1423144008853	PYR/PP interface [polypeptide binding]; other site
1423144008854	TPP binding site [chemical binding]; other site
1423144008855	substrate binding site [chemical binding]; other site
1423144008856	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1423144008857	TPP-binding site [chemical binding]; other site
1423144008858	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
1423144008859	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1423144008860	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1423144008861	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1423144008862	GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051
1423144008863	putative C-terminal domain interface [polypeptide binding]; other site
1423144008864	putative GSH binding site (G-site) [chemical binding]; other site
1423144008865	putative dimer interface [polypeptide binding]; other site
1423144008866	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1423144008867	N-terminal domain interface [polypeptide binding]; other site
1423144008868	dimer interface [polypeptide binding]; other site
1423144008869	substrate binding pocket (H-site) [chemical binding]; other site
1423144008870	S-adenosyl-L-methionine methyltransferase; Region: Methyltransf_17; pfam12692
1423144008871	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1423144008872	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1423144008873	Walker A/P-loop; other site
1423144008874	ATP binding site [chemical binding]; other site
1423144008875	Q-loop/lid; other site
1423144008876	ABC transporter signature motif; other site
1423144008877	Walker B; other site
1423144008878	D-loop; other site
1423144008879	H-loop/switch region; other site
1423144008880	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1423144008881	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1423144008882	Walker A/P-loop; other site
1423144008883	ATP binding site [chemical binding]; other site
1423144008884	Q-loop/lid; other site
1423144008885	ABC transporter signature motif; other site
1423144008886	Walker B; other site
1423144008887	D-loop; other site
1423144008888	H-loop/switch region; other site
1423144008889	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1423144008890	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_4; cd08500
1423144008891	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1423144008892	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1423144008893	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144008894	dimer interface [polypeptide binding]; other site
1423144008895	conserved gate region; other site
1423144008896	putative PBP binding loops; other site
1423144008897	ABC-ATPase subunit interface; other site
1423144008898	glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082
1423144008899	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1423144008900	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144008901	dimer interface [polypeptide binding]; other site
1423144008902	conserved gate region; other site
1423144008903	putative PBP binding loops; other site
1423144008904	ABC-ATPase subunit interface; other site
1423144008905	Predicted acyl-CoA transferases/carnitine dehydratase [Energy production and conversion]; Region: CaiB; COG1804
1423144008906	CoA-transferase family III; Region: CoA_transf_3; pfam02515
1423144008907	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1423144008908	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1423144008909	Predicted glycosyl transferase [General function prediction only]; Region: COG4671
1423144008910	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1423144008911	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
1423144008912	colanic acid biosynthesis glycosyltransferase WcaL; Provisional; Region: PRK15427
1423144008913	putative ADP-binding pocket [chemical binding]; other site
1423144008914	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1423144008915	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1423144008916	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1423144008917	catalytic core [active]
1423144008918	Predicted glycosyl transferase [General function prediction only]; Region: COG4671
1423144008919	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1423144008920	Glycosyltransferase family 28 C-terminal domain; Region: Glyco_tran_28_C; cl17369
1423144008921	Putative catalytic domain of uncharacterized bacterial proteins from the carbohydrate esterase 4 superfamily; Region: CE4_u4; cd10928
1423144008922	NodB motif; other site
1423144008923	putative active site [active]
1423144008924	putative catalytic site [active]
1423144008925	putative Zn binding site [ion binding]; other site
1423144008926	S-adenosyl-L-methionine methyltransferase; Region: Methyltransf_17; pfam12692
1423144008927	phosphonate metabolism protein PhnM; Provisional; Region: PRK15446
1423144008928	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1423144008929	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1423144008930	active site
1423144008931	putative phosphonate metabolism protein; Region: Phn_opern_protn; TIGR03223
1423144008932	Guanylate kinase; Region: Guanylate_kin; pfam00625
1423144008933	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
1423144008934	active site
1423144008935	ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778
1423144008936	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1423144008937	Walker A/P-loop; other site
1423144008938	ATP binding site [chemical binding]; other site
1423144008939	Q-loop/lid; other site
1423144008940	ABC transporter signature motif; other site
1423144008941	Walker B; other site
1423144008942	D-loop; other site
1423144008943	H-loop/switch region; other site
1423144008944	phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701
1423144008945	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1423144008946	Walker A/P-loop; other site
1423144008947	ATP binding site [chemical binding]; other site
1423144008948	Q-loop/lid; other site
1423144008949	ABC transporter signature motif; other site
1423144008950	Walker B; other site
1423144008951	D-loop; other site
1423144008952	H-loop/switch region; other site
1423144008953	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1423144008954	Phosphonate metabolism protein PhnJ; Region: PhnJ; pfam06007
1423144008955	Bacterial phosphonate metabolism protein (PhnI); Region: PhnI; pfam05861
1423144008956	Bacterial phosphonate metabolism protein (PhnH); Region: PhnH; pfam05845
1423144008957	Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754
1423144008958	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1423144008959	DNA-binding site [nucleotide binding]; DNA binding site
1423144008960	phosphonates metabolism transcriptional regulator PhnF; Region: C_P_lyase_phnF; TIGR02325
1423144008961	UTRA domain; Region: UTRA; pfam07702
1423144008962	phosphonate metabolim protein, transferase hexapeptide repeat family; Region: phn_thr-fam; TIGR03308
1423144008963	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
1423144008964	trimer interface [polypeptide binding]; other site
1423144008965	active site
1423144008966	substrate binding site [chemical binding]; other site
1423144008967	CoA binding site [chemical binding]; other site
1423144008968	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1423144008969	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144008970	dimer interface [polypeptide binding]; other site
1423144008971	conserved gate region; other site
1423144008972	ABC-ATPase subunit interface; other site
1423144008973	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
1423144008974	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144008975	dimer interface [polypeptide binding]; other site
1423144008976	conserved gate region; other site
1423144008977	putative PBP binding loops; other site
1423144008978	ABC-ATPase subunit interface; other site
1423144008979	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
1423144008980	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
1423144008981	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
1423144008982	ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256
1423144008983	Walker A/P-loop; other site
1423144008984	ATP binding site [chemical binding]; other site
1423144008985	Q-loop/lid; other site
1423144008986	ABC transporter signature motif; other site
1423144008987	Walker B; other site
1423144008988	D-loop; other site
1423144008989	H-loop/switch region; other site
1423144008990	Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036
1423144008991	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
1423144008992	substrate binding site [chemical binding]; other site
1423144008993	hexamer interface [polypeptide binding]; other site
1423144008994	metal binding site [ion binding]; metal-binding site
1423144008995	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
1423144008996	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1423144008997	acyl-activating enzyme (AAE) consensus motif; other site
1423144008998	AMP binding site [chemical binding]; other site
1423144008999	active site
1423144009000	CoA binding site [chemical binding]; other site
1423144009001	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
1423144009002	CoenzymeA binding site [chemical binding]; other site
1423144009003	subunit interaction site [polypeptide binding]; other site
1423144009004	PHB binding site; other site
1423144009005	pimeloyl-CoA dehydrogenase, small subunit; Region: pimD_small; TIGR03203
1423144009006	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1423144009007	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1423144009008	active site
1423144009009	pimeloyl-CoA dehydrogenase, large subunit; Region: pimC_large; TIGR03204
1423144009010	Putative acyl-CoA dehydrogenases similar to fadE6, fadE17, and fadE26; Region: ACAD_fadE6_17_26; cd01152
1423144009011	FAD binding site [chemical binding]; other site
1423144009012	substrate binding site [chemical binding]; other site
1423144009013	catalytic base [active]
1423144009014	acetyl-CoA acetyltransferase; Provisional; Region: PRK07108
1423144009015	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1423144009016	dimer interface [polypeptide binding]; other site
1423144009017	active site
1423144009018	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1423144009019	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
1423144009020	substrate binding site [chemical binding]; other site
1423144009021	oxyanion hole (OAH) forming residues; other site
1423144009022	trimer interface [polypeptide binding]; other site
1423144009023	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
1423144009024	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1423144009025	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
1423144009026	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
1423144009027	Sulfatase; Region: Sulfatase; cl17466
1423144009028	beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050
1423144009029	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1423144009030	dimer interface [polypeptide binding]; other site
1423144009031	active site
1423144009032	phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778
1423144009033	phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156
1423144009034	phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781
1423144009035	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; pfam05138
1423144009036	Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151
1423144009037	phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159
1423144009038	phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160
1423144009039	NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214
1423144009040	FAD binding pocket [chemical binding]; other site
1423144009041	FAD binding motif [chemical binding]; other site
1423144009042	phosphate binding motif [ion binding]; other site
1423144009043	beta-alpha-beta structure motif; other site
1423144009044	NAD(p) ribose binding residues [chemical binding]; other site
1423144009045	NAD binding pocket [chemical binding]; other site
1423144009046	NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site
1423144009047	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1423144009048	catalytic loop [active]
1423144009049	iron binding site [ion binding]; other site
1423144009050	Phenylacetic acid catabolic protein; Region: PaaA_PaaC; cl01346
1423144009051	aminotransferase; Provisional; Region: PRK13356
1423144009052	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1423144009053	homodimer interface [polypeptide binding]; other site
1423144009054	substrate-cofactor binding pocket; other site
1423144009055	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144009056	catalytic residue [active]
1423144009057	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
1423144009058	Ligand Binding Site [chemical binding]; other site
1423144009059	Scaffold protein Nfu/NifU N terminal; Region: Nfu_N; pfam08712
1423144009060	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
1423144009061	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
1423144009062	Glycoprotease family; Region: Peptidase_M22; pfam00814
1423144009063	ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491
1423144009064	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
1423144009065	Coenzyme A binding pocket [chemical binding]; other site
1423144009066	Periplasmic binding domain of basic membrane lipoprotein, PnrA, in Treponema pallidum and its homologs from other bacteria and Archaea; Region: PBP1_BmpA_PnrA_like; cd06354
1423144009067	Uncharacterized ABC-type transport system, periplasmic component/surface lipoprotein [General function prediction only]; Region: Med; COG1744
1423144009068	ligand binding site [chemical binding]; other site
1423144009069	ABC-type uncharacterized transport systems, ATPase components [General function prediction only]; Region: COG3845
1423144009070	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1423144009071	Walker A/P-loop; other site
1423144009072	ATP binding site [chemical binding]; other site
1423144009073	Q-loop/lid; other site
1423144009074	ABC transporter signature motif; other site
1423144009075	Walker B; other site
1423144009076	D-loop; other site
1423144009077	H-loop/switch region; other site
1423144009078	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1423144009079	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1423144009080	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1423144009081	TM-ABC transporter signature motif; other site
1423144009082	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1423144009083	Transmembrane subunit (TM) of Treponema pallidum (Tp) RbsC-1, RbsC-2 and related proteins. This is a functionally uncharacterized subgroup of TMs which belong to a larger group of TMs of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette; Region: TM_PBP1_transp_TpRbsC_like; cd06580
1423144009084	TM-ABC transporter signature motif; other site
1423144009085	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1423144009086	hypothetical protein; Provisional; Region: PRK10621
1423144009087	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1423144009088	Putative transmembrane protein (Alph_Pro_TM); Region: Alph_Pro_TM; pfam09608
1423144009089	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
1423144009090	classical (c) SDRs; Region: SDR_c; cd05233
1423144009091	NAD(P) binding site [chemical binding]; other site
1423144009092	active site
1423144009093	AAA domain; Region: AAA_30; pfam13604
1423144009094	Family description; Region: UvrD_C_2; pfam13538
1423144009095	Autoinducer synthetase; Region: Autoind_synth; cl17404
1423144009096	Autoinducer binding domain; Region: Autoind_bind; pfam03472
1423144009097	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1423144009098	DNA binding residues [nucleotide binding]
1423144009099	dimerization interface [polypeptide binding]; other site
1423144009100	crotonyl-CoA reductase; Region: crotonyl_coA_red; cd08246
1423144009101	crotonyl-CoA reductase; Region: crot-CoA-red; TIGR01751
1423144009102	putative NAD(P) binding site [chemical binding]; other site
1423144009103	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
1423144009104	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
1423144009105	putative acyl-acceptor binding pocket; other site
1423144009106	Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817
1423144009107	methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071
1423144009108	B12 binding site [chemical binding]; other site
1423144009109	cobalt ligand [ion binding]; other site
1423144009110	H-NS histone family; Region: Histone_HNS; pfam00816
1423144009111	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
1423144009112	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
1423144009113	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
1423144009114	Domain of unknown function (DUF1989); Region: DUF1989; cl01474
1423144009115	Diaminopimelate decarboxylase [Amino acid transport and metabolism]; Region: LysA; COG0019
1423144009116	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Ornithine Decarboxylase; Region: PLPDE_III_ODC; cd00622
1423144009117	dimer interface [polypeptide binding]; other site
1423144009118	active site
1423144009119	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1423144009120	catalytic residues [active]
1423144009121	substrate binding site [chemical binding]; other site
1423144009122	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
1423144009123	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
1423144009124	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK09078
1423144009125	L-aspartate oxidase; Provisional; Region: PRK06175
1423144009126	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
1423144009127	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit-like; composed of predominantly uncharacterized bacterial proteins with similarity to the E. coli SdhD subunit. One characterized protein is the respiratory...; Region: SQR_TypeC_SdhD_like; cd03495
1423144009128	putative SdhC subunit interface [polypeptide binding]; other site
1423144009129	putative proximal heme binding site [chemical binding]; other site
1423144009130	putative Iron-sulfur protein interface [polypeptide binding]; other site
1423144009131	putative proximal quinone binding site; other site
1423144009132	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
1423144009133	Iron-sulfur protein interface; other site
1423144009134	proximal quinone binding site [chemical binding]; other site
1423144009135	SdhD (CybS) interface [polypeptide binding]; other site
1423144009136	proximal heme binding site [chemical binding]; other site
1423144009137	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1423144009138	metal ion-dependent adhesion site (MIDAS); other site
1423144009139	Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040
1423144009140	catalytic core [active]
1423144009141	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
1423144009142	putative active site [active]
1423144009143	putative catalytic site [active]
1423144009144	FkbR2 is a Streptomyces hygroscopicus protein with a hot dog fold that belongs to a conserved family of proteins found in prokaryotes and archaea but not in eukaryotes. FkbR2  has sequence similarity to (R)-specific enoyl-CoA hydratase, the peroxisomal...; Region: FkbR2; cd03451
1423144009145	putative active site [active]
1423144009146	putative catalytic site [active]
1423144009147	Domain of unknown function (DUF1737); Region: DUF1737; cl10503
1423144009148	NnrU protein; Region: NnrU; pfam07298
1423144009149	Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301
1423144009150	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1423144009151	malate dehydrogenase; Reviewed; Region: PRK06223
1423144009152	L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339
1423144009153	NAD(P) binding site [chemical binding]; other site
1423144009154	dimer interface [polypeptide binding]; other site
1423144009155	tetramer (dimer of dimers) interface [polypeptide binding]; other site
1423144009156	substrate binding site [chemical binding]; other site
1423144009157	AAA domain; Region: AAA_28; pfam13521
1423144009158	Predicted ATPase [General function prediction only]; Region: COG3911
1423144009159	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
1423144009160	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
1423144009161	CoA-ligase; Region: Ligase_CoA; pfam00549
1423144009162	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
1423144009163	CoA binding domain; Region: CoA_binding; pfam02629
1423144009164	CoA-ligase; Region: Ligase_CoA; pfam00549
1423144009165	Protein of unknown function (DUF805); Region: DUF805; pfam05656
1423144009166	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
1423144009167	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
1423144009168	TPP-binding site [chemical binding]; other site
1423144009169	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
1423144009170	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1423144009171	E3 interaction surface; other site
1423144009172	lipoyl attachment site [posttranslational modification]; other site
1423144009173	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
1423144009174	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1423144009175	E3 interaction surface; other site
1423144009176	lipoyl attachment site [posttranslational modification]; other site
1423144009177	e3 binding domain; Region: E3_binding; pfam02817
1423144009178	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1423144009179	MAPEG family; Region: MAPEG; pfam01124
1423144009180	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
1423144009181	Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730
1423144009182	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1423144009183	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1423144009184	EthD domain; Region: EthD; cl17553
1423144009185	PPOX class probable FMN-dependent enzyme, DR_2398 family; Region: PPOX_FMN_DR2398; TIGR04025
1423144009186	1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018
1423144009187	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
1423144009188	putative acyl-acceptor binding pocket; other site
1423144009189	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
1423144009190	Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884
1423144009191	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1423144009192	Walker A/P-loop; other site
1423144009193	ATP binding site [chemical binding]; other site
1423144009194	Q-loop/lid; other site
1423144009195	ABC transporter signature motif; other site
1423144009196	Walker B; other site
1423144009197	D-loop; other site
1423144009198	H-loop/switch region; other site
1423144009199	zinc-ribbon domain; Region: zinc_ribbon_5; pfam13719
1423144009200	Domain of unknown function (DUF4175); Region: DUF4175; pfam13779
1423144009201	diaminopimelate decarboxylase; Region: lysA; TIGR01048
1423144009202	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
1423144009203	active site
1423144009204	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1423144009205	substrate binding site [chemical binding]; other site
1423144009206	catalytic residues [active]
1423144009207	dimer interface [polypeptide binding]; other site
1423144009208	argininosuccinate lyase; Provisional; Region: PRK00855
1423144009209	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
1423144009210	active sites [active]
1423144009211	tetramer interface [polypeptide binding]; other site
1423144009212	TlpA-like family; composed of  TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966
1423144009213	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1423144009214	catalytic residues [active]
1423144009215	Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000
1423144009216	Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116
1423144009217	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
1423144009218	putative acyltransferase; Provisional; Region: PRK05790
1423144009219	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1423144009220	dimer interface [polypeptide binding]; other site
1423144009221	active site
1423144009222	acetoacetyl-CoA reductase; Region: AcAcCoA_reduct; TIGR01829
1423144009223	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
1423144009224	NAD(P) binding site [chemical binding]; other site
1423144009225	homotetramer interface [polypeptide binding]; other site
1423144009226	homodimer interface [polypeptide binding]; other site
1423144009227	active site
1423144009228	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1423144009229	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144009230	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
1423144009231	dimerization interface [polypeptide binding]; other site
1423144009232	substrate binding pocket [chemical binding]; other site
1423144009233	aromatic amino acid exporter; Provisional; Region: PRK11689
1423144009234	Protein of unknown function (DUF465); Region: DUF465; cl01070
1423144009235	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
1423144009236	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
1423144009237	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1423144009238	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1423144009239	substrate binding pocket [chemical binding]; other site
1423144009240	chain length determination region; other site
1423144009241	substrate-Mg2+ binding site; other site
1423144009242	catalytic residues [active]
1423144009243	aspartate-rich region 1; other site
1423144009244	active site lid residues [active]
1423144009245	aspartate-rich region 2; other site
1423144009246	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608
1423144009247	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
1423144009248	TPR repeat; Region: TPR_11; pfam13414
1423144009249	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1423144009250	binding surface
1423144009251	TPR motif; other site
1423144009252	TPR repeat; Region: TPR_11; pfam13414
1423144009253	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1423144009254	binding surface
1423144009255	TPR motif; other site
1423144009256	TPR repeat; Region: TPR_11; pfam13414
1423144009257	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
1423144009258	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1423144009259	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
1423144009260	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
1423144009261	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
1423144009262	DNA binding residues [nucleotide binding]
1423144009263	dimer interface [polypeptide binding]; other site
1423144009264	[2Fe-2S] cluster binding site [ion binding]; other site
1423144009265	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1423144009266	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
1423144009267	active site
1423144009268	metal binding site [ion binding]; metal-binding site
1423144009269	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
1423144009270	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
1423144009271	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
1423144009272	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK14690
1423144009273	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
1423144009274	dimer interface [polypeptide binding]; other site
1423144009275	putative functional site; other site
1423144009276	putative MPT binding site; other site
1423144009277	putative molybdopterin-guanine dinucleotide biosynthesis protein MobB/unknown domain fusion protein; Provisional; Region: PRK14495
1423144009278	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
1423144009279	Walker A motif; other site
1423144009280	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
1423144009281	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
1423144009282	GTP binding site; other site
1423144009283	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
1423144009284	AzlC protein; Region: AzlC; pfam03591
1423144009285	Branched-chain amino acid transport protein (AzlD); Region: AzlD; pfam05437
1423144009286	Bacterial aa3 type cytochrome c oxidase subunit IV; Region: COX4_pro_2; pfam07835
1423144009287	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
1423144009288	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1423144009289	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1423144009290	active site
1423144009291	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
1423144009292	Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009
1423144009293	Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481
1423144009294	hypothetical protein; Validated; Region: PRK00228
1423144009295	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
1423144009296	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_15; cd04673
1423144009297	nudix motif; other site
1423144009298	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1423144009299	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1423144009300	HlyD family secretion protein; Region: HlyD_3; pfam13437
1423144009301	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
1423144009302	MPT binding site; other site
1423144009303	trimer interface [polypeptide binding]; other site
1423144009304	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
1423144009305	Fe-S cluster binding site [ion binding]; other site
1423144009306	active site
1423144009307	aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856
1423144009308	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
1423144009309	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
1423144009310	dihydroorotase; Validated; Region: PRK09059
1423144009311	Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317
1423144009312	active site
1423144009313	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
1423144009314	glutamate--cysteine ligase; Region: PLN02611
1423144009315	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
1423144009316	16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713
1423144009317	RNA methyltransferase, RsmE family; Region: TIGR00046
1423144009318	4-hydroxybenzoate polyprenyltransferase; Reviewed; Region: ubiA; PRK12878
1423144009319	UbiA prenyltransferase family; Region: UbiA; pfam01040
1423144009320	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1423144009321	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1423144009322	ligand binding site [chemical binding]; other site
1423144009323	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
1423144009324	MoaE homodimer interface [polypeptide binding]; other site
1423144009325	MoaD interaction [polypeptide binding]; other site
1423144009326	active site residues [active]
1423144009327	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
1423144009328	MoaE interaction surface [polypeptide binding]; other site
1423144009329	MoeB interaction surface [polypeptide binding]; other site
1423144009330	thiocarboxylated glycine; other site
1423144009331	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
1423144009332	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
1423144009333	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
1423144009334	GIY-YIG motif/motif A; other site
1423144009335	active site
1423144009336	catalytic site [active]
1423144009337	putative DNA binding site [nucleotide binding]; other site
1423144009338	metal binding site [ion binding]; metal-binding site
1423144009339	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
1423144009340	short chain dehydrogenase; Provisional; Region: PRK09134
1423144009341	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1423144009342	NAD(P) binding site [chemical binding]; other site
1423144009343	active site
1423144009344	K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367
1423144009345	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1423144009346	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
1423144009347	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
1423144009348	signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706
1423144009349	tandem repeat interface [polypeptide binding]; other site
1423144009350	oligomer interface [polypeptide binding]; other site
1423144009351	active site residues [active]
1423144009352	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1423144009353	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1423144009354	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
1423144009355	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
1423144009356	Walker A/P-loop; other site
1423144009357	ATP binding site [chemical binding]; other site
1423144009358	Q-loop/lid; other site
1423144009359	ABC transporter signature motif; other site
1423144009360	Walker B; other site
1423144009361	D-loop; other site
1423144009362	H-loop/switch region; other site
1423144009363	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1423144009364	NADH(P)-binding; Region: NAD_binding_10; pfam13460
1423144009365	NAD(P) binding site [chemical binding]; other site
1423144009366	active site
1423144009367	4-hydroxybenzoate 3-monooxygenase; Validated; Region: PRK08243
1423144009368	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1423144009369	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
1423144009370	Cupin domain; Region: Cupin_2; cl17218
1423144009371	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1423144009372	Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793
1423144009373	C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526
1423144009374	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
1423144009375	protein binding site [polypeptide binding]; other site
1423144009376	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
1423144009377	Catalytic dyad [active]
1423144009378	Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942
1423144009379	Peptidase family M23; Region: Peptidase_M23; pfam01551
1423144009380	phosphoglyceromutase; Provisional; Region: PRK05434
1423144009381	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
1423144009382	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
1423144009383	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
1423144009384	Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350
1423144009385	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
1423144009386	DNA binding site [nucleotide binding]
1423144009387	active site
1423144009388	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
1423144009389	putative phosphate binding site [ion binding]; other site
1423144009390	glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650
1423144009391	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1423144009392	Walker A/P-loop; other site
1423144009393	ATP binding site [chemical binding]; other site
1423144009394	Q-loop/lid; other site
1423144009395	ABC transporter signature motif; other site
1423144009396	Walker B; other site
1423144009397	D-loop; other site
1423144009398	H-loop/switch region; other site
1423144009399	TOBE domain; Region: TOBE_2; pfam08402
1423144009400	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1423144009401	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144009402	dimer interface [polypeptide binding]; other site
1423144009403	conserved gate region; other site
1423144009404	putative PBP binding loops; other site
1423144009405	ABC-ATPase subunit interface; other site
1423144009406	ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209
1423144009407	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144009408	dimer interface [polypeptide binding]; other site
1423144009409	putative PBP binding loops; other site
1423144009410	ABC-ATPase subunit interface; other site
1423144009411	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1423144009412	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1423144009413	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1423144009414	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1423144009415	DNA binding site [nucleotide binding]
1423144009416	domain linker motif; other site
1423144009417	Ligand-binding domain of uncharacterized DNA-binding regulatory proteins that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_LacI_like_2; cd06278
1423144009418	putative dimerization interface [polypeptide binding]; other site
1423144009419	putative ligand binding site [chemical binding]; other site
1423144009420	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1423144009421	Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586
1423144009422	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1423144009423	Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253
1423144009424	NAD(P) binding site [chemical binding]; other site
1423144009425	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
1423144009426	Predicted integral membrane protein [Function unknown]; Region: COG5616
1423144009427	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1423144009428	TPR motif; other site
1423144009429	binding surface
1423144009430	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1423144009431	TPR motif; other site
1423144009432	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
1423144009433	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1423144009434	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1423144009435	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
1423144009436	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1423144009437	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
1423144009438	acyl-activating enzyme (AAE) consensus motif; other site
1423144009439	putative AMP binding site [chemical binding]; other site
1423144009440	putative active site [active]
1423144009441	putative CoA binding site [chemical binding]; other site
1423144009442	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1423144009443	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1423144009444	Walker A/P-loop; other site
1423144009445	ATP binding site [chemical binding]; other site
1423144009446	Q-loop/lid; other site
1423144009447	ABC transporter signature motif; other site
1423144009448	Walker B; other site
1423144009449	D-loop; other site
1423144009450	H-loop/switch region; other site
1423144009451	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1423144009452	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1423144009453	Walker A/P-loop; other site
1423144009454	ATP binding site [chemical binding]; other site
1423144009455	Q-loop/lid; other site
1423144009456	ABC transporter signature motif; other site
1423144009457	Walker B; other site
1423144009458	D-loop; other site
1423144009459	H-loop/switch region; other site
1423144009460	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1423144009461	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1423144009462	TM-ABC transporter signature motif; other site
1423144009463	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1423144009464	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1423144009465	TM-ABC transporter signature motif; other site
1423144009466	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
1423144009467	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144009468	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1423144009469	dimerization interface [polypeptide binding]; other site
1423144009470	4-carboxymuconolactone decarboxylase; Region: decarb_PcaC; TIGR02425
1423144009471	Intradiol dioxygenases catalyze the critical ring-cleavage step in the conversion of catecholate derivatives to citric acid cycle intermediates. This family contains catechol 1,2-dioxygenases and protocatechuate 3,4-dioxygenases which are mononuclear...; Region: intradiol_dioxygenase; cl17208
1423144009472	protocatechuate 3,4-dioxygenase, beta subunit; Region: protocat_beta; TIGR02422
1423144009473	active site
1423144009474	Protocatechuate 3,4-dioxygenase beta subunit [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PcaH; COG3485
1423144009475	Protocatechuate 3,4-dioxygenase (3,4-PCD) , alpha subunit. 3,4-PCD catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and...; Region: 3,4-PCD_alpha; cd03463
1423144009476	heterodimer interface [polypeptide binding]; other site
1423144009477	active site
1423144009478	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
1423144009479	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
1423144009480	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
1423144009481	DNA binding residues [nucleotide binding]
1423144009482	dimer interface [polypeptide binding]; other site
1423144009483	copper binding site [ion binding]; other site
1423144009484	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1423144009485	metal-binding site [ion binding]
1423144009486	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1423144009487	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1423144009488	metal-binding site [ion binding]
1423144009489	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1423144009490	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1423144009491	motif II; other site
1423144009492	Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062
1423144009493	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1423144009494	NAD(P) binding site [chemical binding]; other site
1423144009495	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1423144009496	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1423144009497	DNA-binding site [nucleotide binding]; DNA binding site
1423144009498	FCD domain; Region: FCD; pfam07729
1423144009499	SpoVR family protein; Provisional; Region: PRK11767
1423144009500	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
1423144009501	hypothetical protein; Provisional; Region: PRK05325
1423144009502	PrkA family serine protein kinase; Provisional; Region: PRK15455
1423144009503	AAA ATPase domain; Region: AAA_16; pfam13191
1423144009504	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
1423144009505	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1423144009506	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1423144009507	Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754
1423144009508	Putative flagellar system-associated repeat; Region: SWM_repeat; pfam13753
1423144009509	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
1423144009510	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
1423144009511	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1423144009512	ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245
1423144009513	Walker A/P-loop; other site
1423144009514	ATP binding site [chemical binding]; other site
1423144009515	Q-loop/lid; other site
1423144009516	ABC transporter signature motif; other site
1423144009517	Walker B; other site
1423144009518	D-loop; other site
1423144009519	H-loop/switch region; other site
1423144009520	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1423144009521	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1423144009522	HlyD family secretion protein; Region: HlyD_3; pfam13437
1423144009523	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
1423144009524	active site
1423144009525	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1423144009526	putative substrate translocation pore; other site
1423144009527	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1423144009528	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
1423144009529	Helix-Turn-Helix DNA binding domain of putative transcription regulators from the MerR superfamily; Region: HTH_MerR-like_sg6; cd04781
1423144009530	DNA binding residues [nucleotide binding]
1423144009531	putative dimer interface [polypeptide binding]; other site
1423144009532	putative metal binding residues [ion binding]; other site
1423144009533	LysE type translocator; Region: LysE; cl00565
1423144009534	Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631
1423144009535	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
1423144009536	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1423144009537	Formate/nitrite transporter; Region: Form_Nir_trans; pfam01226
1423144009538	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
1423144009539	Mechanosensitive ion channel; Region: MS_channel; pfam00924
1423144009540	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
1423144009541	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
1423144009542	NADP-binding site; other site
1423144009543	homotetramer interface [polypeptide binding]; other site
1423144009544	substrate binding site [chemical binding]; other site
1423144009545	homodimer interface [polypeptide binding]; other site
1423144009546	active site
1423144009547	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1423144009548	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1423144009549	catalytic residue [active]
1423144009550	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1423144009551	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1423144009552	active site
1423144009553	NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370
1423144009554	extended (e) SDRs; Region: SDR_e; cd08946
1423144009555	NAD(P) binding site [chemical binding]; other site
1423144009556	active site
1423144009557	substrate binding site [chemical binding]; other site
1423144009558	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
1423144009559	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_1; cd09996
1423144009560	active site
1423144009561	Zn binding site [ion binding]; other site
1423144009562	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1423144009563	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1423144009564	Walker A/P-loop; other site
1423144009565	ATP binding site [chemical binding]; other site
1423144009566	Q-loop/lid; other site
1423144009567	ABC transporter signature motif; other site
1423144009568	Walker B; other site
1423144009569	D-loop; other site
1423144009570	H-loop/switch region; other site
1423144009571	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1423144009572	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1423144009573	Walker A/P-loop; other site
1423144009574	ATP binding site [chemical binding]; other site
1423144009575	Q-loop/lid; other site
1423144009576	ABC transporter signature motif; other site
1423144009577	Walker B; other site
1423144009578	D-loop; other site
1423144009579	H-loop/switch region; other site
1423144009580	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1423144009581	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1423144009582	TM-ABC transporter signature motif; other site
1423144009583	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1423144009584	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1423144009585	TM-ABC transporter signature motif; other site
1423144009586	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1423144009587	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
1423144009588	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1423144009589	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144009590	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1423144009591	dimerization interface [polypeptide binding]; other site
1423144009592	PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865
1423144009593	substrate binding site [chemical binding]; other site
1423144009594	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629
1423144009595	TPP-binding site [chemical binding]; other site
1423144009596	Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958
1423144009597	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
1423144009598	PYR/PP interface [polypeptide binding]; other site
1423144009599	dimer interface [polypeptide binding]; other site
1423144009600	TPP binding site [chemical binding]; other site
1423144009601	Major royal jelly protein; Region: MRJP; pfam03022
1423144009602	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
1423144009603	Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253
1423144009604	NAD(P) binding site [chemical binding]; other site
1423144009605	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1423144009606	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
1423144009607	active site
1423144009608	phosphorylation site [posttranslational modification]
1423144009609	intermolecular recognition site; other site
1423144009610	dimerization interface [polypeptide binding]; other site
1423144009611	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
1423144009612	putative hydrolase; Provisional; Region: PRK11460
1423144009613	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
1423144009614	TMAO/DMSO reductase; Reviewed; Region: PRK05363
1423144009615	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
1423144009616	Moco binding site; other site
1423144009617	metal coordination site [ion binding]; other site
1423144009618	Glutamate synthase domain 2 [Amino acid transport and metabolism]; Region: GltB; COG0069
1423144009619	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1423144009620	active site
1423144009621	FMN binding site [chemical binding]; other site
1423144009622	substrate binding site [chemical binding]; other site
1423144009623	3Fe-4S cluster binding site [ion binding]; other site
1423144009624	Domain of unknown function DUF302; Region: DUF302; cl01364
1423144009625	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
1423144009626	Clp amino terminal domain; Region: Clp_N; pfam02861
1423144009627	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1423144009628	Walker A motif; other site
1423144009629	ATP binding site [chemical binding]; other site
1423144009630	Walker B motif; other site
1423144009631	arginine finger; other site
1423144009632	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1423144009633	Walker A motif; other site
1423144009634	ATP binding site [chemical binding]; other site
1423144009635	Walker B motif; other site
1423144009636	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
1423144009637	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
1423144009638	active site
1423144009639	dimer interface [polypeptide binding]; other site
1423144009640	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_23; cd04682
1423144009641	nudix motif; other site
1423144009642	DNA polymerase IV; Provisional; Region: PRK02794
1423144009643	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
1423144009644	active site
1423144009645	DNA binding site [nucleotide binding]
1423144009646	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
1423144009647	50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831
1423144009648	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
1423144009649	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1423144009650	Protein of unknown function (DUF2938); Region: DUF2938; pfam11158
1423144009651	cobalamin biosynthesis protein CobW; Region: CobW; TIGR02475
1423144009652	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
1423144009653	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683
1423144009654	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1423144009655	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144009656	dimer interface [polypeptide binding]; other site
1423144009657	conserved gate region; other site
1423144009658	putative PBP binding loops; other site
1423144009659	ABC-ATPase subunit interface; other site
1423144009660	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144009661	dimer interface [polypeptide binding]; other site
1423144009662	conserved gate region; other site
1423144009663	putative PBP binding loops; other site
1423144009664	ABC-ATPase subunit interface; other site
1423144009665	Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541
1423144009666	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1423144009667	acyl-activating enzyme (AAE) consensus motif; other site
1423144009668	active site
1423144009669	AMP binding site [chemical binding]; other site
1423144009670	CoA binding site [chemical binding]; other site
1423144009671	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1423144009672	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1423144009673	Walker A/P-loop; other site
1423144009674	ATP binding site [chemical binding]; other site
1423144009675	Q-loop/lid; other site
1423144009676	ABC transporter signature motif; other site
1423144009677	Walker B; other site
1423144009678	D-loop; other site
1423144009679	H-loop/switch region; other site
1423144009680	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_1; cd06334
1423144009681	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1423144009682	putative ligand binding site [chemical binding]; other site
1423144009683	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1423144009684	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1423144009685	TM-ABC transporter signature motif; other site
1423144009686	Short C-terminal domain; Region: SHOCT; pfam09851
1423144009687	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1423144009688	TM-ABC transporter signature motif; other site
1423144009689	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1423144009690	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1423144009691	Walker A/P-loop; other site
1423144009692	ATP binding site [chemical binding]; other site
1423144009693	Q-loop/lid; other site
1423144009694	ABC transporter signature motif; other site
1423144009695	Walker B; other site
1423144009696	D-loop; other site
1423144009697	H-loop/switch region; other site
1423144009698	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
1423144009699	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1423144009700	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
1423144009701	acyl-activating enzyme (AAE) consensus motif; other site
1423144009702	putative active site [active]
1423144009703	putative AMP binding site [chemical binding]; other site
1423144009704	putative CoA binding site [chemical binding]; other site
1423144009705	PAS fold; Region: PAS_7; pfam12860
1423144009706	PAS fold; Region: PAS_4; pfam08448
1423144009707	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1423144009708	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
1423144009709	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1423144009710	ATP binding site [chemical binding]; other site
1423144009711	Mg2+ binding site [ion binding]; other site
1423144009712	G-X-G motif; other site
1423144009713	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144009714	Response regulator receiver domain; Region: Response_reg; pfam00072
1423144009715	active site
1423144009716	phosphorylation site [posttranslational modification]
1423144009717	intermolecular recognition site; other site
1423144009718	dimerization interface [polypeptide binding]; other site
1423144009719	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1423144009720	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144009721	active site
1423144009722	phosphorylation site [posttranslational modification]
1423144009723	intermolecular recognition site; other site
1423144009724	dimerization interface [polypeptide binding]; other site
1423144009725	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1423144009726	DNA binding site [nucleotide binding]
1423144009727	WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996
1423144009728	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
1423144009729	catalytic core [active]
1423144009730	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1423144009731	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
1423144009732	C-terminal domain interface [polypeptide binding]; other site
1423144009733	GSH binding site (G-site) [chemical binding]; other site
1423144009734	dimer interface [polypeptide binding]; other site
1423144009735	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
1423144009736	dimer interface [polypeptide binding]; other site
1423144009737	substrate binding pocket (H-site) [chemical binding]; other site
1423144009738	N-terminal domain interface [polypeptide binding]; other site
1423144009739	Saccharopine Dehydrogenase NAD-binding and catalytic domains; Region: SDH; cd12188
1423144009740	active site
1423144009741	ligand binding site [chemical binding]; other site
1423144009742	homodimer interface [polypeptide binding]; other site
1423144009743	NAD(P) binding site [chemical binding]; other site
1423144009744	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1423144009745	Protein of unknown function (DUF3775); Region: DUF3775; pfam12616
1423144009746	Sodium:dicarboxylate symporter family; Region: SDF; cl00573
1423144009747	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1423144009748	cyclase homology domain; Region: CHD; cd07302
1423144009749	nucleotidyl binding site; other site
1423144009750	metal binding site [ion binding]; metal-binding site
1423144009751	dimer interface [polypeptide binding]; other site
1423144009752	RmuC family; Region: RmuC; pfam02646
1423144009753	DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095
1423144009754	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1423144009755	ATP binding site [chemical binding]; other site
1423144009756	Mg2+ binding site [ion binding]; other site
1423144009757	G-X-G motif; other site
1423144009758	DNA mismatch repair protein, C-terminal domain; Region: DNA_mis_repair; pfam01119
1423144009759	ATP binding site [chemical binding]; other site
1423144009760	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
1423144009761	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1423144009762	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1423144009763	ABC-ATPase subunit  interface; other site
1423144009764	dimer interface [polypeptide binding]; other site
1423144009765	putative PBP binding regions; other site
1423144009766	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1423144009767	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1423144009768	ABC-ATPase subunit  interface; other site
1423144009769	dimer interface [polypeptide binding]; other site
1423144009770	putative PBP binding regions; other site
1423144009771	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
1423144009772	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1423144009773	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
1423144009774	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1423144009775	intersubunit interface [polypeptide binding]; other site
1423144009776	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
1423144009777	intersubunit interface [polypeptide binding]; other site
1423144009778	active site
1423144009779	catalytic residue [active]
1423144009780	Aldehyde dehydrogenase family 16A1-like; Region: ALDH_F16; cd07111
1423144009781	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1423144009782	NAD(P) binding site [chemical binding]; other site
1423144009783	catalytic residues [active]
1423144009784	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1423144009785	NAD(P) binding site [chemical binding]; other site
1423144009786	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1423144009787	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1423144009788	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1423144009789	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
1423144009790	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
1423144009791	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
1423144009792	Protein of unknown function (DUF3035); Region: DUF3035; pfam11233
1423144009793	Signal peptidase (SPase) II; Region: Peptidase_A8; cl00458
1423144009794	lipoprotein signal peptidase; Provisional; Region: PRK14787
1423144009795	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
1423144009796	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
1423144009797	purine monophosphate binding site [chemical binding]; other site
1423144009798	dimer interface [polypeptide binding]; other site
1423144009799	putative catalytic residues [active]
1423144009800	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
1423144009801	Heparinase II/III-like protein; Region: Hepar_II_III; cl15421
1423144009802	NusB family; Region: NusB; pfam01029
1423144009803	putative RNA binding site [nucleotide binding]; other site
1423144009804	16S rRNA methyltransferase B; Provisional; Region: PRK10901
1423144009805	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1423144009806	S-adenosylmethionine binding site [chemical binding]; other site
1423144009807	Uncharacterized conserved small protein [Function unknown]; Region: COG5508
1423144009808	Protein of unknown function (DUF1674); Region: DUF1674; pfam07896
1423144009809	NIPSNAP; Region: NIPSNAP; pfam07978
1423144009810	dihydrodipicolinate reductase; Provisional; Region: PRK00048
1423144009811	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
1423144009812	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
1423144009813	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
1423144009814	Predicted periplasmic protein [Function unknown]; Region: COG3698
1423144009815	Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992
1423144009816	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05389
1423144009817	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
1423144009818	RNA binding site [nucleotide binding]; other site
1423144009819	active site
1423144009820	Protein of unknown function (DUF1643); Region: DUF1643; pfam07799
1423144009821	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
1423144009822	16S/18S rRNA binding site [nucleotide binding]; other site
1423144009823	S13e-L30e interaction site [polypeptide binding]; other site
1423144009824	25S rRNA binding site [nucleotide binding]; other site
1423144009825	Methyltransferase domain; Region: Methyltransf_31; pfam13847
1423144009826	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1423144009827	S-adenosylmethionine binding site [chemical binding]; other site
1423144009828	Predicted methyltransferase regulatory domain; Region: MethyTransf_Reg; pfam10119
1423144009829	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
1423144009830	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
1423144009831	RNase E interface [polypeptide binding]; other site
1423144009832	trimer interface [polypeptide binding]; other site
1423144009833	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
1423144009834	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
1423144009835	RNase E interface [polypeptide binding]; other site
1423144009836	trimer interface [polypeptide binding]; other site
1423144009837	active site
1423144009838	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
1423144009839	putative nucleic acid binding region [nucleotide binding]; other site
1423144009840	G-X-X-G motif; other site
1423144009841	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
1423144009842	RNA binding site [nucleotide binding]; other site
1423144009843	domain interface; other site
1423144009844	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
1423144009845	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
1423144009846	Peroxiredoxin (PRX) family, 1-cys PRX subfamily; composed of PRXs containing only one conserved cysteine, which serves as the peroxidatic cysteine. They are homodimeric thiol-specific antioxidant (TSA) proteins that confer a protective role in cells by...; Region: PRX_1cys; cd03016
1423144009847	dimer interface [polypeptide binding]; other site
1423144009848	decamer (pentamer of dimers) interface [polypeptide binding]; other site
1423144009849	catalytic triad [active]
1423144009850	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
1423144009851	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1423144009852	NAD binding site [chemical binding]; other site
1423144009853	catalytic residues [active]
1423144009854	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
1423144009855	active site
1423144009856	metal binding site [ion binding]; metal-binding site
1423144009857	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1423144009858	Alpha-1,2-fucosyltransferase; Region: Fut1_Fut2_like; cd11301
1423144009859	GDP-Fucose binding site [chemical binding]; other site
1423144009860	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
1423144009861	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
1423144009862	active site
1423144009863	SnoaL-like domain; Region: SnoaL_2; pfam12680
1423144009864	SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836
1423144009865	active site
1423144009866	catalytic triad [active]
1423144009867	oxyanion hole [active]
1423144009868	Predicted permeases [General function prediction only]; Region: RarD; COG2962
1423144009869	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1423144009870	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1423144009871	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
1423144009872	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
1423144009873	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1423144009874	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1423144009875	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1423144009876	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1423144009877	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1423144009878	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1423144009879	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
1423144009880	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1423144009881	Uncharacterized conserved protein [Function unknown]; Region: COG3791
1423144009882	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
1423144009883	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1423144009884	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1423144009885	non-specific DNA binding site [nucleotide binding]; other site
1423144009886	salt bridge; other site
1423144009887	sequence-specific DNA binding site [nucleotide binding]; other site
1423144009888	Cupin domain; Region: Cupin_2; pfam07883
1423144009889	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
1423144009890	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
1423144009891	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1423144009892	dimer interface [polypeptide binding]; other site
1423144009893	active site
1423144009894	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
1423144009895	anti sigma factor interaction site; other site
1423144009896	regulatory phosphorylation site [posttranslational modification]; other site
1423144009897	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
1423144009898	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
1423144009899	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
1423144009900	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
1423144009901	Hemimethylated DNA-binding protein YccV like; Region: YccV-like; pfam08755
1423144009902	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
1423144009903	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
1423144009904	Uncharacterized protein, similar to the N-terminal domain of Lon protease [General function prediction only]; Region: COG2802
1423144009905	Uncharacterized conserved protein [Function unknown]; Region: COG2835
1423144009906	2-octaprenyl-6-methoxyphenyl hydroxylase; Provisional; Region: PRK07333
1423144009907	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1423144009908	Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154
1423144009909	Amidase; Region: Amidase; cl11426
1423144009910	succinyldiaminopimelate transaminase; Provisional; Region: PRK09147
1423144009911	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1423144009912	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144009913	homodimer interface [polypeptide binding]; other site
1423144009914	catalytic residue [active]
1423144009915	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
1423144009916	DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674
1423144009917	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
1423144009918	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
1423144009919	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
1423144009920	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
1423144009921	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1423144009922	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1423144009923	catalytic residue [active]
1423144009924	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
1423144009925	putative catalytic site [active]
1423144009926	putative phosphate binding site [ion binding]; other site
1423144009927	active site
1423144009928	metal binding site A [ion binding]; metal-binding site
1423144009929	DNA binding site [nucleotide binding]
1423144009930	putative AP binding site [nucleotide binding]; other site
1423144009931	putative metal binding site B [ion binding]; other site
1423144009932	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
1423144009933	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144009934	active site
1423144009935	phosphorylation site [posttranslational modification]
1423144009936	intermolecular recognition site; other site
1423144009937	dimerization interface [polypeptide binding]; other site
1423144009938	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1423144009939	DNA binding site [nucleotide binding]
1423144009940	GTP cyclohydrolase; Provisional; Region: PRK08815
1423144009941	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
1423144009942	dimerization interface [polypeptide binding]; other site
1423144009943	active site
1423144009944	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3786
1423144009945	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635
1423144009946	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1423144009947	catalytic residue [active]
1423144009948	Gram-negative porin; Region: Porin_4; pfam13609
1423144009949	Domain of unknown function (DUF3576); Region: DUF3576; pfam12100
1423144009950	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
1423144009951	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
1423144009952	HIGH motif; other site
1423144009953	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
1423144009954	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
1423144009955	active site
1423144009956	KMSKS motif; other site
1423144009957	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
1423144009958	tRNA binding surface [nucleotide binding]; other site
1423144009959	Lipopolysaccharide-assembly; Region: LptE; pfam04390
1423144009960	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK06585
1423144009961	GST_N family, Saccharomyces cerevisiae GTT1-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT1, and the Schizosaccharomyces pombe GST-III. GSTs are cytosolic dimeric proteins involved...; Region: GST_N_GTT1_like; cd03046
1423144009962	putative C-terminal domain interface [polypeptide binding]; other site
1423144009963	putative GSH binding site (G-site) [chemical binding]; other site
1423144009964	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1423144009965	putative dimer interface [polypeptide binding]; other site
1423144009966	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776
1423144009967	N-terminal domain interface [polypeptide binding]; other site
1423144009968	substrate binding pocket (H-site) [chemical binding]; other site
1423144009969	uncharacterized flavoprotein, PP_4765 family; Region: flavo_PP4765; TIGR03862
1423144009970	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083
1423144009971	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1423144009972	substrate binding site [chemical binding]; other site
1423144009973	oxyanion hole (OAH) forming residues; other site
1423144009974	trimer interface [polypeptide binding]; other site
1423144009975	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653
1423144009976	classical (c) SDRs; Region: SDR_c; cd05233
1423144009977	NAD(P) binding site [chemical binding]; other site
1423144009978	active site
1423144009979	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
1423144009980	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1423144009981	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
1423144009982	active site
1423144009983	3-deoxy-D-manno-octulosonic-acid transferase [Cell envelope biogenesis, outer membrane]; Region: KdtA; COG1519
1423144009984	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
1423144009985	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
1423144009986	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
1423144009987	Thioredoxin; Region: Thioredoxin_4; pfam13462
1423144009988	Protein-disulfide isomerase [Posttranslational modification, protein turnover, chaperones]; Region: DsbG; COG1651
1423144009989	Protein of unknown function (DUF721); Region: DUF721; pfam05258
1423144009990	A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194
1423144009991	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
1423144009992	minor groove reading motif; other site
1423144009993	helix-hairpin-helix signature motif; other site
1423144009994	substrate binding pocket [chemical binding]; other site
1423144009995	active site
1423144009996	Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576
1423144009997	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
1423144009998	DNA binding and oxoG recognition site [nucleotide binding]
1423144009999	Alkane hydroxylase is a bacterial, integral-membrane di-iron enzyme that shares a requirement for iron and oxygen for activity similar to that of the non-heme integral-membrane acyl coenzyme A (CoA) desaturases and acyl lipid desaturases. The alk genes...; Region: Alkane-hydroxylase; cd03512
1423144010000	Fatty acid desaturase; Region: FA_desaturase; pfam00487
1423144010001	Di-iron ligands [ion binding]; other site
1423144010002	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1423144010003	cyclase homology domain; Region: CHD; cd07302
1423144010004	nucleotidyl binding site; other site
1423144010005	metal binding site [ion binding]; metal-binding site
1423144010006	dimer interface [polypeptide binding]; other site
1423144010007	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
1423144010008	DNA methylase; Region: N6_N4_Mtase; pfam01555
1423144010009	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
1423144010010	RNA/DNA hybrid binding site [nucleotide binding]; other site
1423144010011	active site
1423144010012	Domain of unknown function (DUF427); Region: DUF427; pfam04248
1423144010013	Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114
1423144010014	cyclase homology domain; Region: CHD; cd07302
1423144010015	nucleotidyl binding site; other site
1423144010016	metal binding site [ion binding]; metal-binding site
1423144010017	dimer interface [polypeptide binding]; other site
1423144010018	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
1423144010019	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182
1423144010020	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1423144010021	tetramer interface [polypeptide binding]; other site
1423144010022	TPP-binding site [chemical binding]; other site
1423144010023	heterodimer interface [polypeptide binding]; other site
1423144010024	phosphorylation loop region [posttranslational modification]
1423144010025	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1423144010026	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1423144010027	alpha subunit interface [polypeptide binding]; other site
1423144010028	TPP binding site [chemical binding]; other site
1423144010029	heterodimer interface [polypeptide binding]; other site
1423144010030	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1423144010031	BCCT family transporter; Region: BCCT; pfam02028
1423144010032	BCCT family transporter; Region: BCCT; pfam02028
1423144010033	urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410
1423144010034	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1423144010035	Walker A/P-loop; other site
1423144010036	ATP binding site [chemical binding]; other site
1423144010037	Q-loop/lid; other site
1423144010038	ABC transporter signature motif; other site
1423144010039	Walker B; other site
1423144010040	D-loop; other site
1423144010041	H-loop/switch region; other site
1423144010042	urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411
1423144010043	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1423144010044	Walker A/P-loop; other site
1423144010045	ATP binding site [chemical binding]; other site
1423144010046	Q-loop/lid; other site
1423144010047	ABC transporter signature motif; other site
1423144010048	Walker B; other site
1423144010049	D-loop; other site
1423144010050	H-loop/switch region; other site
1423144010051	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1423144010052	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1423144010053	TM-ABC transporter signature motif; other site
1423144010054	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1423144010055	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1423144010056	TM-ABC transporter signature motif; other site
1423144010057	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1423144010058	Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355
1423144010059	putative ligand binding site [chemical binding]; other site
1423144010060	UreD urease accessory protein; Region: UreD; pfam01774
1423144010061	Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390
1423144010062	alpha-gamma subunit interface [polypeptide binding]; other site
1423144010063	beta-gamma subunit interface [polypeptide binding]; other site
1423144010064	Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407
1423144010065	gamma-beta subunit interface [polypeptide binding]; other site
1423144010066	alpha-beta subunit interface [polypeptide binding]; other site
1423144010067	urease subunit alpha; Reviewed; Region: ureC; PRK13207
1423144010068	Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375
1423144010069	subunit interactions [polypeptide binding]; other site
1423144010070	active site
1423144010071	flap region; other site
1423144010072	urease accessory protein UreE; Provisional; Region: PRK14113
1423144010073	UreE urease accessory protein. UreE is a metallochaperone assisting the insertion of a Ni2+ ion in the active site of urease, an important step in the in vivo assembly of urease, an enzyme that hydrolyses urea into ammonia and carbamic acid. The...; Region: UreE; cd00571
1423144010074	dimer interface [polypeptide binding]; other site
1423144010075	catalytic residues [active]
1423144010076	Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830
1423144010077	UreF; Region: UreF; pfam01730
1423144010078	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1423144010079	SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229
1423144010080	active site
1423144010081	catalytic triad [active]
1423144010082	oxyanion hole [active]
1423144010083	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
1423144010084	TonB C terminal; Region: TonB_2; pfam13103
1423144010085	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
1423144010086	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
1423144010087	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
1423144010088	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
1423144010089	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
1423144010090	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
1423144010091	N-terminal plug; other site
1423144010092	ligand-binding site [chemical binding]; other site
1423144010093	Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720
1423144010094	Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171
1423144010095	Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171
1423144010096	Hemin binding protein HutB.  These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149
1423144010097	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1423144010098	putative hemin binding site; other site
1423144010099	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1423144010100	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1423144010101	ABC-ATPase subunit  interface; other site
1423144010102	dimer interface [polypeptide binding]; other site
1423144010103	putative PBP binding regions; other site
1423144010104	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
1423144010105	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1423144010106	Walker A/P-loop; other site
1423144010107	ATP binding site [chemical binding]; other site
1423144010108	Q-loop/lid; other site
1423144010109	ABC transporter signature motif; other site
1423144010110	Walker B; other site
1423144010111	D-loop; other site
1423144010112	H-loop/switch region; other site
1423144010113	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1423144010114	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1423144010115	DNA binding site [nucleotide binding]
1423144010116	domain linker motif; other site
1423144010117	Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575
1423144010118	putative dimerization interface [polypeptide binding]; other site
1423144010119	putative ligand binding site [chemical binding]; other site
1423144010120	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
1423144010121	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
1423144010122	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1423144010123	active site
1423144010124	DctM-like transporters; Region: DctM; pfam06808
1423144010125	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
1423144010126	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
1423144010127	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1423144010128	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
1423144010129	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1423144010130	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1423144010131	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
1423144010132	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1423144010133	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
1423144010134	MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579
1423144010135	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
1423144010136	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1423144010137	FeS/SAM binding site; other site
1423144010138	Chloramphenicol (Cm) phosphotransferase (CPT). Cm-inactivating enzyme; modifies the primary (C-3) hydroxyl of the antibiotic. Related structurally to shikimate kinase II; Region: CPT; cl17391
1423144010139	AAA domain; Region: AAA_33; pfam13671
1423144010140	P-loop motif; other site
1423144010141	ATP binding site [chemical binding]; other site
1423144010142	Chloramphenicol (Cm) binding site [chemical binding]; other site
1423144010143	catalytic residue [active]
1423144010144	Cytochrome C1 family; Region: Cytochrom_C1; pfam02167
1423144010145	cytochrome b; Provisional; Region: CYTB; MTH00191
1423144010146	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
1423144010147	intrachain domain interface; other site
1423144010148	interchain domain interface [polypeptide binding]; other site
1423144010149	heme bH binding site [chemical binding]; other site
1423144010150	Qi binding site; other site
1423144010151	heme bL binding site [chemical binding]; other site
1423144010152	Qo binding site; other site
1423144010153	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
1423144010154	interchain domain interface [polypeptide binding]; other site
1423144010155	intrachain domain interface; other site
1423144010156	Qi binding site; other site
1423144010157	Qo binding site; other site
1423144010158	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
1423144010159	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
1423144010160	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
1423144010161	[2Fe-2S] cluster binding site [ion binding]; other site
1423144010162	putative glutathione S-transferase; Provisional; Region: PRK10357
1423144010163	GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049
1423144010164	putative C-terminal domain interface [polypeptide binding]; other site
1423144010165	putative GSH binding site (G-site) [chemical binding]; other site
1423144010166	putative dimer interface [polypeptide binding]; other site
1423144010167	C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205
1423144010168	dimer interface [polypeptide binding]; other site
1423144010169	N-terminal domain interface [polypeptide binding]; other site
1423144010170	putative substrate binding pocket (H-site) [chemical binding]; other site
1423144010171	riboflavin synthase subunit beta; Provisional; Region: PRK12419
1423144010172	active site
1423144010173	homopentamer interface [polypeptide binding]; other site
1423144010174	ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840
1423144010175	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1423144010176	Walker A/P-loop; other site
1423144010177	ATP binding site [chemical binding]; other site
1423144010178	Q-loop/lid; other site
1423144010179	ABC transporter signature motif; other site
1423144010180	Walker B; other site
1423144010181	D-loop; other site
1423144010182	H-loop/switch region; other site
1423144010183	thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433
1423144010184	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144010185	dimer interface [polypeptide binding]; other site
1423144010186	conserved gate region; other site
1423144010187	putative PBP binding loops; other site
1423144010188	ABC-ATPase subunit interface; other site
1423144010189	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
1423144010190	thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205
1423144010191	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
1423144010192	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
1423144010193	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
1423144010194	Tetramer interface [polypeptide binding]; other site
1423144010195	active site
1423144010196	FMN-binding site [chemical binding]; other site
1423144010197	malonyl-CoA synthase; Validated; Region: PRK07514
1423144010198	Malonyl-CoA synthetase (MCS); Region: MCS; cd05941
1423144010199	acyl-activating enzyme (AAE) consensus motif; other site
1423144010200	active site
1423144010201	AMP binding site [chemical binding]; other site
1423144010202	CoA binding site [chemical binding]; other site
1423144010203	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
1423144010204	EamA-like transporter family; Region: EamA; pfam00892
1423144010205	EamA-like transporter family; Region: EamA; cl17759
1423144010206	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1423144010207	MarR family; Region: MarR; pfam01047
1423144010208	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
1423144010209	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1423144010210	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
1423144010211	homodimer interface [polypeptide binding]; other site
1423144010212	substrate-cofactor binding pocket; other site
1423144010213	catalytic residue [active]
1423144010214	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1423144010215	MarR family; Region: MarR_2; pfam12802
1423144010216	osmolarity response regulator; Provisional; Region: ompR; PRK09468
1423144010217	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144010218	active site
1423144010219	phosphorylation site [posttranslational modification]
1423144010220	intermolecular recognition site; other site
1423144010221	dimerization interface [polypeptide binding]; other site
1423144010222	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1423144010223	DNA binding site [nucleotide binding]
1423144010224	Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123
1423144010225	Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII_2; cd11599
1423144010226	putative active site [active]
1423144010227	Zn binding site [ion binding]; other site
1423144010228	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
1423144010229	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
1423144010230	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
1423144010231	substrate binding pocket [chemical binding]; other site
1423144010232	chain length determination region; other site
1423144010233	substrate-Mg2+ binding site; other site
1423144010234	catalytic residues [active]
1423144010235	aspartate-rich region 1; other site
1423144010236	active site lid residues [active]
1423144010237	aspartate-rich region 2; other site
1423144010238	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
1423144010239	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
1423144010240	TPP-binding site; other site
1423144010241	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
1423144010242	PYR/PP interface [polypeptide binding]; other site
1423144010243	dimer interface [polypeptide binding]; other site
1423144010244	TPP binding site [chemical binding]; other site
1423144010245	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1423144010246	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
1423144010247	putative NAD(P) binding site [chemical binding]; other site
1423144010248	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1423144010249	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1423144010250	S-adenosylmethionine binding site [chemical binding]; other site
1423144010251	carnitinyl-CoA dehydratase; Provisional; Region: PRK03580
1423144010252	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1423144010253	substrate binding site [chemical binding]; other site
1423144010254	oxyanion hole (OAH) forming residues; other site
1423144010255	trimer interface [polypeptide binding]; other site
1423144010256	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
1423144010257	CoA binding domain; Region: CoA_binding_2; pfam13380
1423144010258	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
1423144010259	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
1423144010260	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1423144010261	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1423144010262	active site
1423144010263	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1423144010264	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
1423144010265	conserved cys residue [active]
1423144010266	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1423144010267	Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001
1423144010268	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1423144010269	Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295
1423144010270	active site
1423144010271	Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382
1423144010272	AMP nucleosidase; Provisional; Region: PRK08292
1423144010273	Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423
1423144010274	Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775
1423144010275	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
1423144010276	IHF dimer interface [polypeptide binding]; other site
1423144010277	IHF - DNA interface [nucleotide binding]; other site
1423144010278	EamA-like transporter family; Region: EamA; pfam00892
1423144010279	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
1423144010280	EamA-like transporter family; Region: EamA; pfam00892
1423144010281	methionine sulfoxide reductase B; Provisional; Region: PRK00222
1423144010282	SelR domain; Region: SelR; pfam01641
1423144010283	methionine sulfoxide reductase A; Provisional; Region: PRK14054
1423144010284	N-methylhydantoinase A/acetone carboxylase, beta subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuA; COG0145
1423144010285	Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378
1423144010286	Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968
1423144010287	epoxyqueuosine reductase; Region: TIGR00276
1423144010288	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
1423144010289	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
1423144010290	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1423144010291	NAD(P) binding site [chemical binding]; other site
1423144010292	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
1423144010293	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
1423144010294	substrate-cofactor binding pocket; other site
1423144010295	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144010296	catalytic residue [active]
1423144010297	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1423144010298	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1423144010299	non-specific DNA binding site [nucleotide binding]; other site
1423144010300	salt bridge; other site
1423144010301	sequence-specific DNA binding site [nucleotide binding]; other site
1423144010302	Cupin domain; Region: Cupin_2; cl17218
1423144010303	beta-ketothiolase; Provisional; Region: PRK09051
1423144010304	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
1423144010305	dimer interface [polypeptide binding]; other site
1423144010306	active site
1423144010307	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1423144010308	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144010309	dimer interface [polypeptide binding]; other site
1423144010310	conserved gate region; other site
1423144010311	putative PBP binding loops; other site
1423144010312	ABC-ATPase subunit interface; other site
1423144010313	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
1423144010314	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144010315	dimer interface [polypeptide binding]; other site
1423144010316	conserved gate region; other site
1423144010317	putative PBP binding loops; other site
1423144010318	ABC-ATPase subunit interface; other site
1423144010319	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1423144010320	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
1423144010321	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1423144010322	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1423144010323	Walker A/P-loop; other site
1423144010324	ATP binding site [chemical binding]; other site
1423144010325	Q-loop/lid; other site
1423144010326	ABC transporter signature motif; other site
1423144010327	Walker B; other site
1423144010328	D-loop; other site
1423144010329	H-loop/switch region; other site
1423144010330	TOBE domain; Region: TOBE_2; pfam08402
1423144010331	putative aminotransferase; Validated; Region: PRK07480
1423144010332	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1423144010333	inhibitor-cofactor binding pocket; inhibition site
1423144010334	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144010335	catalytic residue [active]
1423144010336	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1423144010337	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1423144010338	DNA-binding site [nucleotide binding]; DNA binding site
1423144010339	FCD domain; Region: FCD; pfam07729
1423144010340	putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682
1423144010341	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1423144010342	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
1423144010343	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1423144010344	Walker A/P-loop; other site
1423144010345	ATP binding site [chemical binding]; other site
1423144010346	Q-loop/lid; other site
1423144010347	ABC transporter signature motif; other site
1423144010348	Walker B; other site
1423144010349	D-loop; other site
1423144010350	H-loop/switch region; other site
1423144010351	TOBE domain; Region: TOBE_2; pfam08402
1423144010352	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144010353	dimer interface [polypeptide binding]; other site
1423144010354	conserved gate region; other site
1423144010355	putative PBP binding loops; other site
1423144010356	ABC-ATPase subunit interface; other site
1423144010357	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1423144010358	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144010359	dimer interface [polypeptide binding]; other site
1423144010360	conserved gate region; other site
1423144010361	putative PBP binding loops; other site
1423144010362	ABC-ATPase subunit interface; other site
1423144010363	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
1423144010364	UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087
1423144010365	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
1423144010366	NAD binding site [chemical binding]; other site
1423144010367	homodimer interface [polypeptide binding]; other site
1423144010368	active site
1423144010369	substrate binding site [chemical binding]; other site
1423144010370	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
1423144010371	dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209
1423144010372	active site
1423144010373	tetramer interface; other site
1423144010374	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
1423144010375	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
1423144010376	Ligand binding site; other site
1423144010377	oligomer interface; other site
1423144010378	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
1423144010379	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
1423144010380	active site
1423144010381	ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682
1423144010382	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1423144010383	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
1423144010384	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
1423144010385	Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733
1423144010386	nucleotide binding site [chemical binding]; other site
1423144010387	NEF interaction site [polypeptide binding]; other site
1423144010388	SBD interface [polypeptide binding]; other site
1423144010389	chaperone protein DnaJ; Provisional; Region: PRK10767
1423144010390	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
1423144010391	HSP70 interaction site [polypeptide binding]; other site
1423144010392	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
1423144010393	substrate binding site [polypeptide binding]; other site
1423144010394	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
1423144010395	Zn binding sites [ion binding]; other site
1423144010396	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
1423144010397	dimer interface [polypeptide binding]; other site
1423144010398	hypothetical protein; Reviewed; Region: PRK00024
1423144010399	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
1423144010400	MPN+ (JAMM) motif; other site
1423144010401	Zinc-binding site [ion binding]; other site
1423144010402	PBP superfamily domain; Region: PBP_like_2; pfam12849
1423144010403	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
1423144010404	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
1423144010405	ligand binding site [chemical binding]; other site
1423144010406	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
1423144010407	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
1423144010408	SEC-C motif; Region: SEC-C; pfam02810
1423144010409	peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059
1423144010410	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
1423144010411	Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152
1423144010412	heterotetramer interface [polypeptide binding]; other site
1423144010413	active site pocket [active]
1423144010414	cleavage site
1423144010415	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
1423144010416	active site
1423144010417	8-oxo-dGMP binding site [chemical binding]; other site
1423144010418	nudix motif; other site
1423144010419	metal binding site [ion binding]; metal-binding site
1423144010420	translation initiation factor IF-2; Region: IF-2; TIGR00487
1423144010421	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
1423144010422	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
1423144010423	G1 box; other site
1423144010424	putative GEF interaction site [polypeptide binding]; other site
1423144010425	GTP/Mg2+ binding site [chemical binding]; other site
1423144010426	Switch I region; other site
1423144010427	G2 box; other site
1423144010428	G3 box; other site
1423144010429	Switch II region; other site
1423144010430	G4 box; other site
1423144010431	G5 box; other site
1423144010432	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
1423144010433	Translation-initiation factor 2; Region: IF-2; pfam11987
1423144010434	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
1423144010435	hypothetical protein; Provisional; Region: PRK09190
1423144010436	Ylxr homologs; group of conserved hypothetical bacterial proteins of unknown function; structure revealed putative RNA binding cleft; proteins are encoded by an operon that includes other proteins involved in transcription and/or translation; Region: YlxR; cd00279
1423144010437	putative RNA binding cleft [nucleotide binding]; other site
1423144010438	Ribosomal protein L7Ae/L30e/S12e/Gadd45 family; Region: Ribosomal_L7Ae; cl00600
1423144010439	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
1423144010440	NusA N-terminal domain; Region: NusA_N; pfam08529
1423144010441	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
1423144010442	RNA binding site [nucleotide binding]; other site
1423144010443	homodimer interface [polypeptide binding]; other site
1423144010444	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1423144010445	G-X-X-G motif; other site
1423144010446	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
1423144010447	G-X-X-G motif; other site
1423144010448	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
1423144010449	ribosome maturation protein RimP; Reviewed; Region: PRK00092
1423144010450	Sm and related proteins; Region: Sm_like; cl00259
1423144010451	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
1423144010452	putative oligomer interface [polypeptide binding]; other site
1423144010453	putative RNA binding site [nucleotide binding]; other site
1423144010454	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
1423144010455	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1423144010456	proline iminopeptidase, Neisseria-type subfamily; Region: pro_imino_pep_1; TIGR01249
1423144010457	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
1423144010458	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1423144010459	S-adenosylmethionine binding site [chemical binding]; other site
1423144010460	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1423144010461	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1423144010462	MarR family; Region: MarR_2; pfam12802
1423144010463	nitrilase; Region: PLN02798
1423144010464	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
1423144010465	putative active site [active]
1423144010466	catalytic triad [active]
1423144010467	dimer interface [polypeptide binding]; other site
1423144010468	Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418
1423144010469	GSH binding site [chemical binding]; other site
1423144010470	catalytic residues [active]
1423144010471	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
1423144010472	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
1423144010473	active site
1423144010474	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
1423144010475	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
1423144010476	ferrochelatase; Reviewed; Region: hemH; PRK00035
1423144010477	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
1423144010478	C-terminal domain interface [polypeptide binding]; other site
1423144010479	active site
1423144010480	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
1423144010481	active site
1423144010482	N-terminal domain interface [polypeptide binding]; other site
1423144010483	hypothetical protein; Provisional; Region: PRK06148
1423144010484	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1423144010485	active site
1423144010486	ATP binding site [chemical binding]; other site
1423144010487	Peptidase family M23; Region: Peptidase_M23; pfam01551
1423144010488	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
1423144010489	inhibitor-cofactor binding pocket; inhibition site
1423144010490	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144010491	catalytic residue [active]
1423144010492	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1423144010493	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
1423144010494	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1423144010495	Ion transport protein; Region: Ion_trans; pfam00520
1423144010496	SAM-dependent methyltransferases related to tRNA (uracil-5-)-methyltransferase [Translation, ribosomal structure and biogenesis]; Region: TrmA; COG2265
1423144010497	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1423144010498	S-adenosylmethionine binding site [chemical binding]; other site
1423144010499	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1423144010500	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1423144010501	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
1423144010502	Walker A/P-loop; other site
1423144010503	ATP binding site [chemical binding]; other site
1423144010504	Q-loop/lid; other site
1423144010505	ABC transporter signature motif; other site
1423144010506	Walker B; other site
1423144010507	D-loop; other site
1423144010508	H-loop/switch region; other site
1423144010509	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1423144010510	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1423144010511	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1423144010512	Walker A/P-loop; other site
1423144010513	ATP binding site [chemical binding]; other site
1423144010514	Q-loop/lid; other site
1423144010515	ABC transporter signature motif; other site
1423144010516	Walker B; other site
1423144010517	D-loop; other site
1423144010518	H-loop/switch region; other site
1423144010519	tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617
1423144010520	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
1423144010521	active site
1423144010522	NTP binding site [chemical binding]; other site
1423144010523	metal binding triad [ion binding]; metal-binding site
1423144010524	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
1423144010525	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
1423144010526	putative active site [active]
1423144010527	putative CoA binding site [chemical binding]; other site
1423144010528	nudix motif; other site
1423144010529	metal binding site [ion binding]; metal-binding site
1423144010530	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
1423144010531	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
1423144010532	dimerization interface [polypeptide binding]; other site
1423144010533	domain crossover interface; other site
1423144010534	redox-dependent activation switch; other site
1423144010535	Contains a crystal structure of the Nudix hydrolase from Enterococcus faecalis, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_25; cd04684
1423144010536	nudix motif; other site
1423144010537	Response regulator receiver domain; Region: Response_reg; pfam00072
1423144010538	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144010539	active site
1423144010540	phosphorylation site [posttranslational modification]
1423144010541	intermolecular recognition site; other site
1423144010542	dimerization interface [polypeptide binding]; other site
1423144010543	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1423144010544	Hpt domain; Region: Hpt; pfam01627
1423144010545	putative binding surface; other site
1423144010546	active site
1423144010547	threonine dehydratase; Validated; Region: PRK08639
1423144010548	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
1423144010549	tetramer interface [polypeptide binding]; other site
1423144010550	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144010551	catalytic residue [active]
1423144010552	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
1423144010553	putative Ile/Val binding site [chemical binding]; other site
1423144010554	argininosuccinate synthase; Provisional; Region: PRK13820
1423144010555	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
1423144010556	ANP binding site [chemical binding]; other site
1423144010557	Substrate Binding Site II [chemical binding]; other site
1423144010558	Substrate Binding Site I [chemical binding]; other site
1423144010559	Protein of unknown function (DUF1810); Region: DUF1810; pfam08837
1423144010560	SCP-2 sterol transfer family; Region: SCP2; pfam02036
1423144010561	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
1423144010562	D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558
1423144010563	homodimer interface [polypeptide binding]; other site
1423144010564	substrate-cofactor binding pocket; other site
1423144010565	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144010566	catalytic residue [active]
1423144010567	Peptide methionine sulfoxide reductase; Region: PMSR; pfam01625
1423144010568	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1423144010569	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
1423144010570	substrate binding site [chemical binding]; other site
1423144010571	dimer interface [polypeptide binding]; other site
1423144010572	ATP binding site [chemical binding]; other site
1423144010573	bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232
1423144010574	Malic enzyme, N-terminal domain; Region: malic; pfam00390
1423144010575	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
1423144010576	putative NAD(P) binding site [chemical binding]; other site
1423144010577	Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280
1423144010578	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
1423144010579	MutS domain I; Region: MutS_I; pfam01624
1423144010580	MutS domain II; Region: MutS_II; pfam05188
1423144010581	MutS domain III; Region: MutS_III; pfam05192
1423144010582	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
1423144010583	Walker A/P-loop; other site
1423144010584	ATP binding site [chemical binding]; other site
1423144010585	Q-loop/lid; other site
1423144010586	ABC transporter signature motif; other site
1423144010587	Walker B; other site
1423144010588	D-loop; other site
1423144010589	H-loop/switch region; other site
1423144010590	GrpE; Region: GrpE; pfam01025
1423144010591	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
1423144010592	dimer interface [polypeptide binding]; other site
1423144010593	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
1423144010594	heat-inducible transcription repressor; Provisional; Region: hrcA; PRK00082
1423144010595	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
1423144010596	ribonuclease PH; Reviewed; Region: rph; PRK00173
1423144010597	Ribonuclease PH; Region: RNase_PH_bact; cd11362
1423144010598	hexamer interface [polypeptide binding]; other site
1423144010599	active site
1423144010600	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
1423144010601	active site
1423144010602	dimerization interface [polypeptide binding]; other site
1423144010603	coproporphyrinogen III oxidase; Provisional; Region: PRK09057
1423144010604	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1423144010605	FeS/SAM binding site; other site
1423144010606	HemN C-terminal domain; Region: HemN_C; pfam06969
1423144010607	Protein of unknown function (DUF454); Region: DUF454; pfam04304
1423144010608	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
1423144010609	ParB-like nuclease domain; Region: ParBc; pfam02195
1423144010610	KorB domain; Region: KorB; pfam08535
1423144010611	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1423144010612	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1423144010613	P-loop; other site
1423144010614	Magnesium ion binding site [ion binding]; other site
1423144010615	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1423144010616	Magnesium ion binding site [ion binding]; other site
1423144010617	Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357
1423144010618	16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107
1423144010619	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
1423144010620	tRNA (uracil-5-)-methyltransferase Gid; Reviewed; Region: PRK05335
1423144010621	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
1423144010622	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
1423144010623	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
1423144010624	trmE is a tRNA modification GTPase; Region: trmE; cd04164
1423144010625	G1 box; other site
1423144010626	GTP/Mg2+ binding site [chemical binding]; other site
1423144010627	Switch I region; other site
1423144010628	G2 box; other site
1423144010629	Switch II region; other site
1423144010630	G3 box; other site
1423144010631	G4 box; other site
1423144010632	G5 box; other site
1423144010633	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
1423144010634	transcription termination factor Rho; Provisional; Region: rho; PRK09376
1423144010635	Rho termination factor, N-terminal domain; Region: Rho_N; pfam07498
1423144010636	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
1423144010637	RNA binding site [nucleotide binding]; other site
1423144010638	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
1423144010639	multimer interface [polypeptide binding]; other site
1423144010640	Walker A motif; other site
1423144010641	ATP binding site [chemical binding]; other site
1423144010642	Walker B motif; other site
1423144010643	Uncharacterized protein family (UPF0093); Region: UPF0093; pfam03653
1423144010644	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
1423144010645	active site
1423144010646	dimer interface [polypeptide binding]; other site
1423144010647	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
1423144010648	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
1423144010649	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
1423144010650	shikimate binding site; other site
1423144010651	NAD(P) binding site [chemical binding]; other site
1423144010652	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
1423144010653	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
1423144010654	CoA-binding site [chemical binding]; other site
1423144010655	ATP-binding [chemical binding]; other site
1423144010656	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
1423144010657	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
1423144010658	active site
1423144010659	catalytic site [active]
1423144010660	substrate binding site [chemical binding]; other site
1423144010661	Preprotein translocase subunit SecB; Region: SecB; pfam02556
1423144010662	SecA binding site; other site
1423144010663	Preprotein binding site; other site
1423144010664	FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186
1423144010665	Tim44-like domain; Region: Tim44; pfam04280
1423144010666	MltA specific insert domain; Region: MltA; smart00925
1423144010667	3D domain; Region: 3D; pfam06725
1423144010668	Smr domain; Region: Smr; pfam01713
1423144010669	Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990
1423144010670	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
1423144010671	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1423144010672	Walker A motif; other site
1423144010673	ATP binding site [chemical binding]; other site
1423144010674	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
1423144010675	Walker B motif; other site
1423144010676	arginine finger; other site
1423144010677	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
1423144010678	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
1423144010679	active site
1423144010680	HslU subunit interaction site [polypeptide binding]; other site
1423144010681	Domain of unknown function (DUF1127); Region: DUF1127; pfam06568
1423144010682	Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; pfam09585
1423144010683	Conserved hypothetical protein (Lin0512_fam); Region: Lin0512_fam; pfam09585
1423144010684	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
1423144010685	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
1423144010686	catalytic residues [active]
1423144010687	double-strand break repair helicase AddA, alphaproteobacterial type; Region: addA_alphas; TIGR02784
1423144010688	Part of AAA domain; Region: AAA_19; pfam13245
1423144010689	Family description; Region: UvrD_C_2; pfam13538
1423144010690	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
1423144010691	double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786
1423144010692	CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641
1423144010693	NTP_transferase_like_1 is a member of the nucleotidyl transferase family; Region: NTP_transferase_like_1; cd06422
1423144010694	Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208
1423144010695	Substrate binding site; other site
1423144010696	metal-binding site
1423144010697	Predicted phosphotransferase related to Ser/Thr protein kinases [General function prediction only]; Region: COG3178
1423144010698	Phosphotransferase enzyme family; Region: APH; pfam01636
1423144010699	Predicted ATPase or kinase [General function prediction only]; Region: COG0802
1423144010700	PAS fold; Region: PAS_7; pfam12860
1423144010701	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1423144010702	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1423144010703	dimer interface [polypeptide binding]; other site
1423144010704	phosphorylation site [posttranslational modification]
1423144010705	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1423144010706	ATP binding site [chemical binding]; other site
1423144010707	Mg2+ binding site [ion binding]; other site
1423144010708	G-X-G motif; other site
1423144010709	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
1423144010710	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
1423144010711	Cu(I) binding site [ion binding]; other site
1423144010712	Response regulator consisting of a CheY-like receiver domain and a Fis-type HTH domain [Signal transduction mechanisms / Transcription]; Region: COG4567
1423144010713	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144010714	active site
1423144010715	phosphorylation site [posttranslational modification]
1423144010716	intermolecular recognition site; other site
1423144010717	dimerization interface [polypeptide binding]; other site
1423144010718	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
1423144010719	Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896
1423144010720	S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476
1423144010721	S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401
1423144010722	homotetramer interface [polypeptide binding]; other site
1423144010723	ligand binding site [chemical binding]; other site
1423144010724	catalytic site [active]
1423144010725	NAD binding site [chemical binding]; other site
1423144010726	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; cl06814
1423144010727	PRC-barrel domain; Region: PRC; pfam05239
1423144010728	Protein of unknown function (DUF2853); Region: DUF2853; pfam11015
1423144010729	Protein of unknown function (DUF1761); Region: DUF1761; pfam08570
1423144010730	EVE domain; Region: EVE; cl00728
1423144010731	YciI-like protein; Reviewed; Region: PRK12863
1423144010732	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
1423144010733	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
1423144010734	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
1423144010735	UGMP family protein; Validated; Region: PRK09604
1423144010736	Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884
1423144010737	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
1423144010738	active site
1423144010739	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4223
1423144010740	Uncharacterized membrane-bound protein [Function unknown]; Region: COG3898
1423144010741	HemY protein N-terminus; Region: HemY_N; pfam07219
1423144010742	choline dehydrogenase; Validated; Region: PRK02106
1423144010743	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1423144010744	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07008
1423144010745	Fatty acyl-CoA synthetases similar to LC-FACS from Thermus thermophiles; Region: ttLC_FACS_AlkK_like; cd12119
1423144010746	dimer interface [polypeptide binding]; other site
1423144010747	acyl-activating enzyme (AAE) consensus motif; other site
1423144010748	putative active site [active]
1423144010749	AMP binding site [chemical binding]; other site
1423144010750	putative CoA binding site [chemical binding]; other site
1423144010751	Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360
1423144010752	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
1423144010753	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931
1423144010754	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
1423144010755	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1423144010756	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
1423144010757	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1423144010758	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07521
1423144010759	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1423144010760	flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK06008
1423144010761	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1423144010762	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
1423144010763	Flagellar P-ring protein; Region: FlgI; pfam02119
1423144010764	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
1423144010765	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
1423144010766	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
1423144010767	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
1423144010768	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
1423144010769	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
1423144010770	Uncharacterized conserved protein [Function unknown]; Region: COG3334
1423144010771	flagellar motor protein MotA; Validated; Region: PRK09110
1423144010772	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
1423144010773	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1423144010774	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1423144010775	catalytic residue [active]
1423144010776	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
1423144010777	FHIPEP family; Region: FHIPEP; pfam00771
1423144010778	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
1423144010779	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
1423144010780	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
1423144010781	Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063
1423144010782	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
1423144010783	SAF-like; Region: SAF_2; pfam13144
1423144010784	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
1423144010785	flagellar basal body rod protein FlgG; Reviewed; Region: flgG; PRK12691
1423144010786	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1423144010787	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1423144010788	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12690
1423144010789	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
1423144010790	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
1423144010791	Bacterial export proteins, family 3; Region: Bac_export_3; pfam01313
1423144010792	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00790
1423144010793	flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12632
1423144010794	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
1423144010795	flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12627
1423144010796	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
1423144010797	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1423144010798	Walker A motif; other site
1423144010799	ATP binding site [chemical binding]; other site
1423144010800	Walker B motif; other site
1423144010801	flagellar biosynthesis repressor FlbT; Reviewed; Region: flbT; PRK00794
1423144010802	flagellar biosynthesis regulatory protein FlaF; Reviewed; Region: flaF; PRK12794
1423144010803	flagellin; Reviewed; Region: PRK12687
1423144010804	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
1423144010805	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
1423144010806	FlgN protein; Region: FlgN; pfam05130
1423144010807	Rod binding protein; Region: Rod-binding; pfam10135
1423144010808	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
1423144010809	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
1423144010810	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
1423144010811	Phosphotransferase enzyme family; Region: APH; pfam01636
1423144010812	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
1423144010813	active site
1423144010814	substrate binding site [chemical binding]; other site
1423144010815	ATP binding site [chemical binding]; other site
1423144010816	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
1423144010817	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
1423144010818	active site
1423144010819	Core-2/I-Branching enzyme; Region: Branch; pfam02485
1423144010820	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
1423144010821	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
1423144010822	active site
1423144010823	phosphorylation site [posttranslational modification]
1423144010824	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
1423144010825	30S subunit binding site; other site
1423144010826	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
1423144010827	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
1423144010828	Walker A/P-loop; other site
1423144010829	ATP binding site [chemical binding]; other site
1423144010830	Q-loop/lid; other site
1423144010831	ABC transporter signature motif; other site
1423144010832	Walker B; other site
1423144010833	D-loop; other site
1423144010834	H-loop/switch region; other site
1423144010835	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
1423144010836	OstA-like protein; Region: OstA; pfam03968
1423144010837	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
1423144010838	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
1423144010839	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
1423144010840	putative active site [active]
1423144010841	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
1423144010842	Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349
1423144010843	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
1423144010844	catalytic site [active]
1423144010845	putative active site [active]
1423144010846	putative substrate binding site [chemical binding]; other site
1423144010847	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
1423144010848	heme-binding site [chemical binding]; other site
1423144010849	NADH dehydrogenase (ubiquinone) 1 alpha subcomplex, subunit 9, 39 kDa, (NDUFA9) -like, atypical (a) SDRs; Region: NDUFA9_like_SDR_a; cd05271
1423144010850	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
1423144010851	putative NAD(P) binding site [chemical binding]; other site
1423144010852	active site
1423144010853	Bacitracin resistance protein BacA; Region: BacA; pfam02673
1423144010854	dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749
1423144010855	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1423144010856	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
1423144010857	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
1423144010858	active site
1423144010859	dimer interface [polypeptide binding]; other site
1423144010860	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
1423144010861	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
1423144010862	active site
1423144010863	FMN binding site [chemical binding]; other site
1423144010864	substrate binding site [chemical binding]; other site
1423144010865	3Fe-4S cluster binding site [ion binding]; other site
1423144010866	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
1423144010867	domain interface; other site
1423144010868	Transglycosylase; Region: Transgly; cl17702
1423144010869	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
1423144010870	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1423144010871	C-terminal domain interface [polypeptide binding]; other site
1423144010872	GSH binding site (G-site) [chemical binding]; other site
1423144010873	dimer interface [polypeptide binding]; other site
1423144010874	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
1423144010875	N-terminal domain interface [polypeptide binding]; other site
1423144010876	dimer interface [polypeptide binding]; other site
1423144010877	substrate binding pocket (H-site) [chemical binding]; other site
1423144010878	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1423144010879	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
1423144010880	active site
1423144010881	metal binding site [ion binding]; metal-binding site
1423144010882	D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581
1423144010883	Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173
1423144010884	ligand binding site [chemical binding]; other site
1423144010885	NAD binding site [chemical binding]; other site
1423144010886	dimerization interface [polypeptide binding]; other site
1423144010887	catalytic site [active]
1423144010888	C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902
1423144010889	putative L-serine binding site [chemical binding]; other site
1423144010890	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cd01494
1423144010891	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1423144010892	catalytic residue [active]
1423144010893	serC leader
1423144010894	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
1423144010895	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1423144010896	motif II; other site
1423144010897	hypothetical protein; Provisional; Region: PRK10621
1423144010898	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
1423144010899	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1423144010900	dimerization interface [polypeptide binding]; other site
1423144010901	putative DNA binding site [nucleotide binding]; other site
1423144010902	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1423144010903	putative Zn2+ binding site [ion binding]; other site
1423144010904	BofC C-terminal domain; Region: BofC_C; pfam08955
1423144010905	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1423144010906	putative hydrophobic ligand binding site [chemical binding]; other site
1423144010907	YCII-related domain; Region: YCII; cl00999
1423144010908	L-asparaginase II; Region: Asparaginase_II; pfam06089
1423144010909	Invasion associated locus B (IalB) protein; Region: IalB; cl02207
1423144010910	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
1423144010911	Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820
1423144010912	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377
1423144010913	FeS/SAM binding site; other site
1423144010914	Zinc-dependent metalloprotease, serralysin_like subfamily. Serralysins and related proteases are important virulence factors in pathogenic bacteria. They may be secreted into the medium via a mechanism found in gram-negative bacteria, that does not...; Region: ZnMc_serralysin_like; cd04277
1423144010915	active site
1423144010916	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
1423144010917	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
1423144010918	hypothetical protein; Provisional; Region: PRK06815
1423144010919	threonine dehydratase; Provisional; Region: PRK08246
1423144010920	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1423144010921	catalytic residue [active]
1423144010922	Transcriptional regulators [Transcription]; Region: FadR; COG2186
1423144010923	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1423144010924	DNA-binding site [nucleotide binding]; DNA binding site
1423144010925	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
1423144010926	2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830
1423144010927	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350
1423144010928	trimer interface [polypeptide binding]; other site
1423144010929	active site
1423144010930	substrate binding site [chemical binding]; other site
1423144010931	CoA binding site [chemical binding]; other site
1423144010932	urocanate hydratase; Provisional; Region: PRK05414
1423144010933	RNA recognition motif (RRM) superfamily; Region: RRM_SF; cl17169
1423144010934	N-formylglutamate amidohydrolase; Region: FGase; cl01522
1423144010935	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
1423144010936	active sites [active]
1423144010937	tetramer interface [polypeptide binding]; other site
1423144010938	imidazolonepropionase; Validated; Region: PRK09356
1423144010939	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
1423144010940	active site
1423144010941	N-formimino-L-glutamate deiminase; Validated; Region: PRK09229
1423144010942	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1423144010943	active site
1423144010944	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
1423144010945	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1423144010946	DNA-binding site [nucleotide binding]; DNA binding site
1423144010947	UTRA domain; Region: UTRA; pfam07702
1423144010948	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1423144010949	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1423144010950	substrate binding pocket [chemical binding]; other site
1423144010951	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1423144010952	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1423144010953	membrane-bound complex binding site; other site
1423144010954	hinge residues; other site
1423144010955	Hint domain; Region: Hint_2; pfam13403
1423144010956	Hint domain; Region: Hint_2; pfam13403
1423144010957	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
1423144010958	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
1423144010959	metal binding site [ion binding]; metal-binding site
1423144010960	dimer interface [polypeptide binding]; other site
1423144010961	ribonuclease R; Region: RNase_R; TIGR02063
1423144010962	RNB domain; Region: RNB; pfam00773
1423144010963	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
1423144010964	RNA binding site [nucleotide binding]; other site
1423144010965	Predicted transcriptional regulator [Transcription]; Region: COG2378
1423144010966	HTH domain; Region: HTH_11; pfam08279
1423144010967	WYL domain; Region: WYL; pfam13280
1423144010968	Transglycosylase SLT domain; Region: SLT_2; pfam13406
1423144010969	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1423144010970	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1423144010971	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1423144010972	ABC1 family; Region: ABC1; cl17513
1423144010973	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
1423144010974	Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226
1423144010975	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
1423144010976	S-adenosylmethionine binding site [chemical binding]; other site
1423144010977	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
1423144010978	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
1423144010979	DNA binding site [nucleotide binding]
1423144010980	catalytic residue [active]
1423144010981	H2TH interface [polypeptide binding]; other site
1423144010982	putative catalytic residues [active]
1423144010983	turnover-facilitating residue; other site
1423144010984	intercalation triad [nucleotide binding]; other site
1423144010985	8OG recognition residue [nucleotide binding]; other site
1423144010986	putative reading head residues; other site
1423144010987	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
1423144010988	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
1423144010989	enoyl-CoA hydratase; Provisional; Region: PRK05862
1423144010990	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1423144010991	substrate binding site [chemical binding]; other site
1423144010992	oxyanion hole (OAH) forming residues; other site
1423144010993	trimer interface [polypeptide binding]; other site
1423144010994	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
1423144010995	Winged helix-turn-helix transcription repressor, HrcA DNA-binding; Region: HrcA_DNA-bdg; pfam03444
1423144010996	DnaA N-terminal domain; Region: DnaA_N; pfam11638
1423144010997	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
1423144010998	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1423144010999	P-loop; other site
1423144011000	Magnesium ion binding site [ion binding]; other site
1423144011001	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1423144011002	Magnesium ion binding site [ion binding]; other site
1423144011003	plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454
1423144011004	ParB-like nuclease domain; Region: ParB; smart00470
1423144011005	glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218
1423144011006	active site
1423144011007	catalytic residues [active]
1423144011008	Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685
1423144011009	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1423144011010	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1423144011011	active site
1423144011012	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
1423144011013	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1423144011014	active site
1423144011015	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
1423144011016	O-Antigen ligase; Region: Wzy_C; pfam04932
1423144011017	exopolysaccharide transport protein family; Region: eps_transp_fam; TIGR01005
1423144011018	Chain length determinant protein; Region: Wzz; pfam02706
1423144011019	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
1423144011020	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1423144011021	ExoA is involved in the biosynthesis of succinoglycan; Region: Succinoglycan_BP_ExoA; cd02525
1423144011022	Ligand binding site; other site
1423144011023	Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641
1423144011024	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
1423144011025	active site
1423144011026	Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692
1423144011027	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1423144011028	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
1423144011029	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1423144011030	Type I periplasmic binding domain of uncharacterized extracellular ligand-binding proteins; Region: PBP1_STKc_like; cd06326
1423144011031	putative ligand binding site [chemical binding]; other site
1423144011032	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1423144011033	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1423144011034	dimer interface [polypeptide binding]; other site
1423144011035	putative CheW interface [polypeptide binding]; other site
1423144011036	AzlC protein; Region: AzlC; cl00570
1423144011037	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1423144011038	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1423144011039	putative DNA binding site [nucleotide binding]; other site
1423144011040	putative Zn2+ binding site [ion binding]; other site
1423144011041	AsnC family; Region: AsnC_trans_reg; pfam01037
1423144011042	H+ Antiporter protein; Region: 2A0121; TIGR00900
1423144011043	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1423144011044	putative substrate translocation pore; other site
1423144011045	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1423144011046	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144011047	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1423144011048	dimerization interface [polypeptide binding]; other site
1423144011049	choline dehydrogenase; Validated; Region: PRK02106
1423144011050	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1423144011051	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
1423144011052	Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316
1423144011053	L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948
1423144011054	active site pocket [active]
1423144011055	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1423144011056	Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109
1423144011057	NAD(P) binding site [chemical binding]; other site
1423144011058	catalytic residues [active]
1423144011059	catalytic residues [active]
1423144011060	Protein of unknown function (DUF1289); Region: DUF1289; cl01304
1423144011061	DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783
1423144011062	DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043
1423144011063	dimerization interface [polypeptide binding]; other site
1423144011064	DPS ferroxidase diiron center [ion binding]; other site
1423144011065	ion pore; other site
1423144011066	Transcriptional regulators [Transcription]; Region: GntR; COG1802
1423144011067	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1423144011068	DNA-binding site [nucleotide binding]; DNA binding site
1423144011069	FCD domain; Region: FCD; pfam07729
1423144011070	Proline racemase [Amino acid transport and metabolism]; Region: COG3938
1423144011071	hydroxyproline-2-epimerase; Provisional; Region: PRK13971
1423144011072	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1423144011073	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1423144011074	non-specific DNA binding site [nucleotide binding]; other site
1423144011075	salt bridge; other site
1423144011076	sequence-specific DNA binding site [nucleotide binding]; other site
1423144011077	Cupin domain; Region: Cupin_2; pfam07883
1423144011078	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1423144011079	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cd00995
1423144011080	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1423144011081	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144011082	dimer interface [polypeptide binding]; other site
1423144011083	conserved gate region; other site
1423144011084	putative PBP binding loops; other site
1423144011085	ABC-ATPase subunit interface; other site
1423144011086	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1423144011087	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1423144011088	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144011089	dimer interface [polypeptide binding]; other site
1423144011090	conserved gate region; other site
1423144011091	Binding-protein-dependent transport system inner membrane component; Region: BPD_transp_1; pfam00528
1423144011092	ABC-ATPase subunit interface; other site
1423144011093	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1423144011094	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1423144011095	Walker A/P-loop; other site
1423144011096	ATP binding site [chemical binding]; other site
1423144011097	Q-loop/lid; other site
1423144011098	ABC transporter signature motif; other site
1423144011099	Walker B; other site
1423144011100	D-loop; other site
1423144011101	H-loop/switch region; other site
1423144011102	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
1423144011103	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
1423144011104	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1423144011105	Walker A/P-loop; other site
1423144011106	ATP binding site [chemical binding]; other site
1423144011107	Q-loop/lid; other site
1423144011108	ABC transporter signature motif; other site
1423144011109	Walker B; other site
1423144011110	D-loop; other site
1423144011111	H-loop/switch region; other site
1423144011112	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1423144011113	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
1423144011114	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1423144011115	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
1423144011116	active site
1423144011117	Cache domain; Region: Cache_1; pfam02743
1423144011118	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
1423144011119	dimerization interface [polypeptide binding]; other site
1423144011120	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1423144011121	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1423144011122	dimer interface [polypeptide binding]; other site
1423144011123	putative CheW interface [polypeptide binding]; other site
1423144011124	colanic acid exporter; Provisional; Region: PRK10459
1423144011125	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127
1423144011126	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1423144011127	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
1423144011128	active site
1423144011129	catalytic residues [active]
1423144011130	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
1423144011131	Family description; Region: VCBS; pfam13517
1423144011132	Family description; Region: VCBS; pfam13517
1423144011133	Family description; Region: VCBS; pfam13517
1423144011134	Family description; Region: VCBS; pfam13517
1423144011135	ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593
1423144011136	MarR family; Region: MarR_2; pfam12802
1423144011137	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
1423144011138	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
1423144011139	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
1423144011140	D-xylose ABC transporter, substrate-binding protein; Region: xylF; TIGR02634
1423144011141	putative ligand binding site [chemical binding]; other site
1423144011142	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1423144011143	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1423144011144	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1423144011145	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1423144011146	TM-ABC transporter signature motif; other site
1423144011147	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1423144011148	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1423144011149	Walker A/P-loop; other site
1423144011150	ATP binding site [chemical binding]; other site
1423144011151	Q-loop/lid; other site
1423144011152	ABC transporter signature motif; other site
1423144011153	Walker B; other site
1423144011154	D-loop; other site
1423144011155	H-loop/switch region; other site
1423144011156	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
1423144011157	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
1423144011158	DNA binding residues [nucleotide binding]
1423144011159	dimer interface [polypeptide binding]; other site
1423144011160	putative metal binding site [ion binding]; other site
1423144011161	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
1423144011162	Uncharacterized protein family (UPF0156); Region: RHH_2; cl17383
1423144011163	DNA ligase, ATP-dependent, PP_1105 family; Region: DNA_lig_bact; TIGR04120
1423144011164	Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897
1423144011165	active site
1423144011166	DNA binding site [nucleotide binding]
1423144011167	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972
1423144011168	DNA binding site [nucleotide binding]
1423144011169	putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122
1423144011170	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
1423144011171	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
1423144011172	Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569
1423144011173	Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028
1423144011174	active site
1423144011175	DNA binding site [nucleotide binding]
1423144011176	Int/Topo IB signature motif; other site
1423144011177	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1423144011178	Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100
1423144011179	NAD(P) binding site [chemical binding]; other site
1423144011180	catalytic residues [active]
1423144011181	putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916
1423144011182	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1423144011183	FeS/SAM binding site; other site
1423144011184	probable DNA metabolism protein; Region: SAM_7_link_chp; TIGR03915
1423144011185	Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030
1423144011186	Fe-S cluster binding site [ion binding]; other site
1423144011187	active site
1423144011188	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
1423144011189	Protein of unknown function (DUF2886); Region: DUF2886; pfam11102
1423144011190	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
1423144011191	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1423144011192	phosphoprotein phosphatases of the metallophosphatase superfamily, metallophosphatase domain; Region: MPP_PPP_family; cd00144
1423144011193	active site
1423144011194	metal binding site [ion binding]; metal-binding site
1423144011195	Predicted membrane protein [Function unknown]; Region: COG2311
1423144011196	Protein of unknown function (DUF1624); Region: DUF1624; cl01394
1423144011197	Protein of unknown function (DUF418); Region: DUF418; pfam04235
1423144011198	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
1423144011199	Transglycosylase SLT domain; Region: SLT_2; pfam13406
1423144011200	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1423144011201	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1423144011202	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1423144011203	Predicted periplasmic protein [Function unknown]; Region: COG3904
1423144011204	Talin, middle domain; Region: Talin_middle; pfam09141
1423144011205	MgtC family; Region: MgtC; pfam02308
1423144011206	RsbT co-antagonist protein rsbRD N-terminal domain; Region: RsbRD_N; pfam14361
1423144011207	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
1423144011208	Sulphate Transporter and Anti-Sigma factor antagonist domain of the "stressosome" complex proteins RsbS and RsbR, regulators of the bacterial stress activated alternative sigma factor sigma-B by phosphorylation; Region: STAS_RsbR_RsbS_like; cd07041
1423144011209	Anti-sigma regulatory factor (Ser/Thr protein kinase) [Signal transduction mechanisms]; Region: RsbW; COG2172
1423144011210	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1423144011211	ATP binding site [chemical binding]; other site
1423144011212	Mg2+ binding site [ion binding]; other site
1423144011213	G-X-G motif; other site
1423144011214	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
1423144011215	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
1423144011216	Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228
1423144011217	Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581
1423144011218	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG3920
1423144011219	Histidine kinase; Region: HisKA_2; pfam07568
1423144011220	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1423144011221	ATP binding site [chemical binding]; other site
1423144011222	Mg2+ binding site [ion binding]; other site
1423144011223	G-X-G motif; other site
1423144011224	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
1423144011225	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666
1423144011226	metal binding site [ion binding]; metal-binding site
1423144011227	putative dimer interface [polypeptide binding]; other site
1423144011228	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
1423144011229	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
1423144011230	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1423144011231	catalytic residue [active]
1423144011232	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
1423144011233	AsnC family; Region: AsnC_trans_reg; pfam01037
1423144011234	Transglycosylase SLT domain; Region: SLT_2; pfam13406
1423144011235	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
1423144011236	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1423144011237	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1423144011238	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
1423144011239	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1423144011240	NAD(P) binding site [chemical binding]; other site
1423144011241	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1423144011242	active site
1423144011243	bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563
1423144011244	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
1423144011245	NAD(P) binding site [chemical binding]; other site
1423144011246	catalytic residues [active]
1423144011247	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
1423144011248	active site 2 [active]
1423144011249	active site 1 [active]
1423144011250	phosphopantothenoylcysteine decarboxylase, streptococcal; Region: coaC_strep; TIGR02113
1423144011251	Flavoprotein; Region: Flavoprotein; pfam02441
1423144011252	PAP2, haloperoxidase_like subfamily. Haloperoxidases catalyze the oxidation of halides such as bromide or chloride by hydrogen peroxide, which results in subsequent halogenation of organic substrates, or halide-assisted disproportionation of hydrogen...; Region: PAP2_haloperoxidase; cd03398
1423144011253	active site
1423144011254	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
1423144011255	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
1423144011256	transmembrane helices; other site
1423144011257	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
1423144011258	homodimer interaction site [polypeptide binding]; other site
1423144011259	cofactor binding site; other site
1423144011260	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
1423144011261	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_21; cd08520
1423144011262	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1423144011263	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144011264	dimer interface [polypeptide binding]; other site
1423144011265	conserved gate region; other site
1423144011266	putative PBP binding loops; other site
1423144011267	ABC-ATPase subunit interface; other site
1423144011268	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1423144011269	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
1423144011270	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1423144011271	Walker A/P-loop; other site
1423144011272	ATP binding site [chemical binding]; other site
1423144011273	Q-loop/lid; other site
1423144011274	ABC transporter signature motif; other site
1423144011275	Walker B; other site
1423144011276	D-loop; other site
1423144011277	H-loop/switch region; other site
1423144011278	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1423144011279	Walker A/P-loop; other site
1423144011280	ATP binding site [chemical binding]; other site
1423144011281	Q-loop/lid; other site
1423144011282	ABC transporter signature motif; other site
1423144011283	Walker B; other site
1423144011284	D-loop; other site
1423144011285	H-loop/switch region; other site
1423144011286	Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703
1423144011287	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
1423144011288	putative active site pocket [active]
1423144011289	dimerization interface [polypeptide binding]; other site
1423144011290	putative catalytic residue [active]
1423144011291	Peptidase family M23; Region: Peptidase_M23; pfam01551
1423144011292	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1423144011293	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
1423144011294	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
1423144011295	active site
1423144011296	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
1423144011297	active site
1423144011298	Prephenate dehydratase; Region: PDT; pfam00800
1423144011299	GST_N family, Beta etherase LigE subfamily; composed of proteins similar to Sphingomonas paucimobilis beta etherase, LigE, a GST-like protein that catalyzes the cleavage of the beta-aryl ether linkages present in low-moleculer weight lignins using GSH as...; Region: GST_N_etherase_LigE; cd03038
1423144011300	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
1423144011301	putative C-terminal domain interface [polypeptide binding]; other site
1423144011302	putative GSH binding site (G-site) [chemical binding]; other site
1423144011303	putative dimer interface [polypeptide binding]; other site
1423144011304	C-terminal, alpha helical domain of Beta etherase LigE; Region: GST_C_etherase_LigE; cd03202
1423144011305	putative N-terminal domain interface [polypeptide binding]; other site
1423144011306	putative dimer interface [polypeptide binding]; other site
1423144011307	putative substrate binding pocket (H-site) [chemical binding]; other site
1423144011308	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1423144011309	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144011310	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1423144011311	dimerization interface [polypeptide binding]; other site
1423144011312	cell density-dependent motility repressor; Provisional; Region: PRK10082
1423144011313	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144011314	LysR substrate binding domain; Region: LysR_substrate; pfam03466
1423144011315	dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308
1423144011316	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1423144011317	Walker A/P-loop; other site
1423144011318	ATP binding site [chemical binding]; other site
1423144011319	Q-loop/lid; other site
1423144011320	ABC transporter signature motif; other site
1423144011321	Walker B; other site
1423144011322	D-loop; other site
1423144011323	H-loop/switch region; other site
1423144011324	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1423144011325	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
1423144011326	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
1423144011327	Walker A/P-loop; other site
1423144011328	ATP binding site [chemical binding]; other site
1423144011329	Q-loop/lid; other site
1423144011330	ABC transporter signature motif; other site
1423144011331	Walker B; other site
1423144011332	D-loop; other site
1423144011333	H-loop/switch region; other site
1423144011334	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
1423144011335	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
1423144011336	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
1423144011337	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144011338	dimer interface [polypeptide binding]; other site
1423144011339	conserved gate region; other site
1423144011340	putative PBP binding loops; other site
1423144011341	ABC-ATPase subunit interface; other site
1423144011342	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
1423144011343	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144011344	dimer interface [polypeptide binding]; other site
1423144011345	conserved gate region; other site
1423144011346	putative PBP binding loops; other site
1423144011347	ABC-ATPase subunit interface; other site
1423144011348	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
1423144011349	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
1423144011350	Protein of unknown function (DUF995); Region: DUF995; pfam06191
1423144011351	Hint domain; Region: Hint_2; pfam13403
1423144011352	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1423144011353	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1423144011354	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
1423144011355	Ca2+ binding site [ion binding]; other site
1423144011356	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
1423144011357	Ca2+ binding site [ion binding]; other site
1423144011358	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
1423144011359	Ca2+ binding site [ion binding]; other site
1423144011360	Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304
1423144011361	Ca2+ binding site [ion binding]; other site
1423144011362	choice-of-anchor C domain; Region: choice_anch_C; TIGR04362
1423144011363	Cadherin repeat-like domain; Region: CA_like; cl15786
1423144011364	Ca2+ binding site [ion binding]; other site
1423144011365	domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758
1423144011366	domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758
1423144011367	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1423144011368	ABC transporter; Region: ABC_tran; pfam00005
1423144011369	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1423144011370	ABC transporter signature motif; other site
1423144011371	Walker B; other site
1423144011372	D-loop; other site
1423144011373	H-loop/switch region; other site
1423144011374	type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842
1423144011375	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1423144011376	Walker A/P-loop; other site
1423144011377	ATP binding site [chemical binding]; other site
1423144011378	Q-loop/lid; other site
1423144011379	ABC transporter signature motif; other site
1423144011380	Walker B; other site
1423144011381	D-loop; other site
1423144011382	H-loop/switch region; other site
1423144011383	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1423144011384	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
1423144011385	HlyD family secretion protein; Region: HlyD_3; pfam13437
1423144011386	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1423144011387	LysR substrate binding domain; Region: LysR_substrate; pfam03466
1423144011388	dimerization interface [polypeptide binding]; other site
1423144011389	Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942
1423144011390	active site 1 [active]
1423144011391	dimer interface [polypeptide binding]; other site
1423144011392	hexamer interface [polypeptide binding]; other site
1423144011393	active site 2 [active]
1423144011394	Putative lumazine-binding; Region: Lumazine_bd_2; pfam12893
1423144011395	glutathionine S-transferase; Provisional; Region: PRK10542
1423144011396	GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057
1423144011397	C-terminal domain interface [polypeptide binding]; other site
1423144011398	GSH binding site (G-site) [chemical binding]; other site
1423144011399	dimer interface [polypeptide binding]; other site
1423144011400	C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188
1423144011401	N-terminal domain interface [polypeptide binding]; other site
1423144011402	dimer interface [polypeptide binding]; other site
1423144011403	substrate binding pocket (H-site) [chemical binding]; other site
1423144011404	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1423144011405	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144011406	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1423144011407	dimerization interface [polypeptide binding]; other site
1423144011408	Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981
1423144011409	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1423144011410	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
1423144011411	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1423144011412	pseudoazurin; Region: pseudoazurin; TIGR02375
1423144011413	Plastocyanin [Energy production and conversion]; Region: PetE; COG3794
1423144011414	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
1423144011415	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1423144011416	Walker A/P-loop; other site
1423144011417	ATP binding site [chemical binding]; other site
1423144011418	Q-loop/lid; other site
1423144011419	ABC transporter signature motif; other site
1423144011420	Walker B; other site
1423144011421	D-loop; other site
1423144011422	H-loop/switch region; other site
1423144011423	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
1423144011424	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1423144011425	ABC-ATPase subunit  interface; other site
1423144011426	dimer interface [polypeptide binding]; other site
1423144011427	putative PBP binding regions; other site
1423144011428	ferrichrome/ferrioxamine B periplasmic transporter; Provisional; Region: PRK14048
1423144011429	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1423144011430	intersubunit interface [polypeptide binding]; other site
1423144011431	Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182
1423144011432	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
1423144011433	PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703
1423144011434	NnrS protein; Region: NnrS; pfam05940
1423144011435	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
1423144011436	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
1423144011437	metal ion-dependent adhesion site (MIDAS); other site
1423144011438	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
1423144011439	MoxR-like ATPases [General function prediction only]; Region: COG0714
1423144011440	Walker A motif; other site
1423144011441	ATP binding site [chemical binding]; other site
1423144011442	Walker B motif; other site
1423144011443	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
1423144011444	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
1423144011445	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
1423144011446	Putative water exit pathway; other site
1423144011447	Binuclear center (active site) [active]
1423144011448	K-pathway; other site
1423144011449	Putative proton exit pathway; other site
1423144011450	Cytochrome c; Region: Cytochrom_C; pfam00034
1423144011451	hybrid cluster protein-associated redox disulfide domain; Region: prismane_assoc; TIGR03980
1423144011452	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
1423144011453	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
1423144011454	ligand binding site [chemical binding]; other site
1423144011455	flexible hinge region; other site
1423144011456	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
1423144011457	putative switch regulator; other site
1423144011458	non-specific DNA interactions [nucleotide binding]; other site
1423144011459	DNA binding site [nucleotide binding]
1423144011460	sequence specific DNA binding site [nucleotide binding]; other site
1423144011461	putative cAMP binding site [chemical binding]; other site
1423144011462	nitrite reductase, copper-containing; Region: Cu_nitrite_red; TIGR02376
1423144011463	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1423144011464	Multicopper oxidase; Region: Cu-oxidase; pfam00394
1423144011465	Uncharacterized conserved protein [Function unknown]; Region: COG1262
1423144011466	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
1423144011467	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1423144011468	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1423144011469	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1423144011470	Helix-turn-helix domain; Region: HTH_18; pfam12833
1423144011471	Cupin domain; Region: Cupin_2; pfam07883
1423144011472	Predicted flavoprotein involved in K+ transport [Inorganic ion transport and metabolism]; Region: TrkA; COG2072
1423144011473	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738
1423144011474	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258
1423144011475	MOSC domain; Region: MOSC; pfam03473
1423144011476	MarR family; Region: MarR_2; pfam12802
1423144011477	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1423144011478	Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal  ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185
1423144011479	FMN-binding pocket [chemical binding]; other site
1423144011480	flavin binding motif; other site
1423144011481	phosphate binding motif [ion binding]; other site
1423144011482	beta-alpha-beta structure motif; other site
1423144011483	NAD binding pocket [chemical binding]; other site
1423144011484	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1423144011485	catalytic loop [active]
1423144011486	iron binding site [ion binding]; other site
1423144011487	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
1423144011488	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144011489	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1423144011490	dimerization interface [polypeptide binding]; other site
1423144011491	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1423144011492	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1423144011493	[2Fe-2S] cluster binding site [ion binding]; other site
1423144011494	C-terminal catalytic domain of the oxygenase alpha subunit of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C; cd00680
1423144011495	alpha subunit interface [polypeptide binding]; other site
1423144011496	active site
1423144011497	substrate binding site [chemical binding]; other site
1423144011498	Fe binding site [ion binding]; other site
1423144011499	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
1423144011500	Uncharacterized Saccharopolyspora spinosa aldehyde dehydrogenase (AAS00426)-like; Region: ALDH_AAS00426; cd07109
1423144011501	NAD(P) binding site [chemical binding]; other site
1423144011502	catalytic residues [active]
1423144011503	catalytic residues [active]
1423144011504	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1423144011505	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1423144011506	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
1423144011507	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
1423144011508	Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404
1423144011509	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1423144011510	Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900
1423144011511	Protein of unknown function (DUF3726); Region: DUF3726; pfam12525
1423144011512	BCCT family transporter; Region: BCCT; pfam02028
1423144011513	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
1423144011514	Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355
1423144011515	active site
1423144011516	Bacillus subtilis NADP+-dependent alpha-ketoglutaric semialdehyde dehydrogenase ycbD-like; Region: ALDH_KGSADH-YcbD; cd07097
1423144011517	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1423144011518	NAD(P) binding site [chemical binding]; other site
1423144011519	catalytic residues [active]
1423144011520	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1423144011521	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144011522	TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440
1423144011523	putative dimerization interface [polypeptide binding]; other site
1423144011524	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1423144011525	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
1423144011526	conserved cys residue [active]
1423144011527	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1423144011528	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1423144011529	Sarcosine oxidase, gamma subunit family; Region: SoxG; cl01893
1423144011530	sarcosine oxidase, alpha subunit family, heterotetrameric form; Region: soxA; TIGR01372
1423144011531	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_4; pfam13510
1423144011532	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1423144011533	Sarcosine oxidase, delta subunit family; Region: SoxD; pfam04267
1423144011534	sarcosine oxidase, beta subunit family, heterotetrameric form; Region: soxB; TIGR01373
1423144011535	hydroxyglutarate oxidase; Provisional; Region: PRK11728
1423144011536	Cytochrome c2 [Energy production and conversion]; Region: COG3474
1423144011537	coenzyme PQQ synthesis protein PqqA; Provisional; Region: pqqA; PRK00284
1423144011538	pyrroloquinoline quinone biosynthesis protein PqqB; Provisional; Region: PRK05184
1423144011539	pyrroloquinoline quinone biosynthesis protein PqqC; Provisional; Region: PRK05157
1423144011540	Coenzyme PQQ synthesis protein D (PqqD); Region: PqqD; pfam05402
1423144011541	pyrroloquinoline quinone biosynthesis protein PqqE; Provisional; Region: PRK05301
1423144011542	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1423144011543	FeS/SAM binding site; other site
1423144011544	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
1423144011545	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
1423144011546	metal ion-dependent adhesion site (MIDAS); other site
1423144011547	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144011548	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1423144011549	dimer interface [polypeptide binding]; other site
1423144011550	conserved gate region; other site
1423144011551	putative PBP binding loops; other site
1423144011552	ABC-ATPase subunit interface; other site
1423144011553	FMN-binding domain; Region: FMN_bind; cl01081
1423144011554	ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163
1423144011555	4Fe-4S binding domain; Region: Fer4_5; pfam12801
1423144011556	4Fe-4S binding domain; Region: Fer4_5; pfam12801
1423144011557	ApbE family; Region: ApbE; pfam02424
1423144011558	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
1423144011559	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
1423144011560	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
1423144011561	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
1423144011562	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
1423144011563	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
1423144011564	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1423144011565	catalytic loop [active]
1423144011566	iron binding site [ion binding]; other site
1423144011567	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
1423144011568	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1423144011569	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1423144011570	substrate binding pocket [chemical binding]; other site
1423144011571	membrane-bound complex binding site; other site
1423144011572	hinge residues; other site
1423144011573	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1423144011574	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
1423144011575	ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683
1423144011576	Periplasmic binding domain of ATP-binding cassette transporter-like systems that belong to the type I periplasmic binding fold protein superfamily; Region: PBP1_ABC_transporter_LIVBP_like; cd06268
1423144011577	ligand binding site [chemical binding]; other site
1423144011578	PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866
1423144011579	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1423144011580	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1423144011581	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
1423144011582	ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864
1423144011583	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1423144011584	Walker A/P-loop; other site
1423144011585	ATP binding site [chemical binding]; other site
1423144011586	Q-loop/lid; other site
1423144011587	ABC transporter signature motif; other site
1423144011588	Walker B; other site
1423144011589	D-loop; other site
1423144011590	H-loop/switch region; other site
1423144011591	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1423144011592	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
1423144011593	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
1423144011594	cell division ATP-binding protein FtsE; Region: FtsE; TIGR02673
1423144011595	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1423144011596	Walker A/P-loop; other site
1423144011597	ATP binding site [chemical binding]; other site
1423144011598	Q-loop/lid; other site
1423144011599	ABC transporter signature motif; other site
1423144011600	Walker B; other site
1423144011601	D-loop; other site
1423144011602	H-loop/switch region; other site
1423144011603	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cl17432
1423144011604	membrane-bound complex binding site; other site
1423144011605	PQQ-dependent dehydrogenase, methanol/ethanol family; Region: PQQ_enz_alc_DH; TIGR03075
1423144011606	Ethanol dehydrogenase, a bacterial quinoprotein (PQQ-dependent type I alcohol dehydrogenase); Region: PQQ_ADH_I; cd10277
1423144011607	dimer interface [polypeptide binding]; other site
1423144011608	Trp docking motif [polypeptide binding]; other site
1423144011609	active site
1423144011610	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
1423144011611	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
1423144011612	DNA-binding site [nucleotide binding]; DNA binding site
1423144011613	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1423144011614	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144011615	homodimer interface [polypeptide binding]; other site
1423144011616	catalytic residue [active]
1423144011617	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
1423144011618	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
1423144011619	substrate binding site [chemical binding]; other site
1423144011620	oxyanion hole (OAH) forming residues; other site
1423144011621	trimer interface [polypeptide binding]; other site
1423144011622	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
1423144011623	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
1423144011624	active site
1423144011625	Acetyl-CoA dehydrogenase C-terminal like; Region: Acyl-CoA_dh_C; pfam12806
1423144011626	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
1423144011627	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1423144011628	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1423144011629	Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704
1423144011630	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
1423144011631	metal binding site 2 [ion binding]; metal-binding site
1423144011632	putative DNA binding helix; other site
1423144011633	dimer interface [polypeptide binding]; other site
1423144011634	structural Zn2+ binding site [ion binding]; other site
1423144011635	metal binding site 1 [ion binding]; metal-binding site
1423144011636	Protein of unknown function (DUF2796); Region: DUF2796; pfam10986
1423144011637	Protein of unknown function (DUF2796); Region: DUF2796; pfam10986
1423144011638	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
1423144011639	putative bacteriocin export ABC transporter, lactococcin 972 group; Region: L_ocin_972_ABC; TIGR03608
1423144011640	Walker A/P-loop; other site
1423144011641	ATP binding site [chemical binding]; other site
1423144011642	Q-loop/lid; other site
1423144011643	ABC transporter signature motif; other site
1423144011644	Walker B; other site
1423144011645	D-loop; other site
1423144011646	H-loop/switch region; other site
1423144011647	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
1423144011648	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
1423144011649	FtsX-like permease family; Region: FtsX; pfam02687
1423144011650	Protein of unknown function (DUF3299); Region: DUF3299; pfam11736
1423144011651	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
1423144011652	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144011653	active site
1423144011654	phosphorylation site [posttranslational modification]
1423144011655	intermolecular recognition site; other site
1423144011656	dimerization interface [polypeptide binding]; other site
1423144011657	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
1423144011658	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
1423144011659	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
1423144011660	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
1423144011661	putative CheA interaction surface; other site
1423144011662	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
1423144011663	putative binding surface; other site
1423144011664	active site
1423144011665	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
1423144011666	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
1423144011667	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1423144011668	ATP binding site [chemical binding]; other site
1423144011669	Mg2+ binding site [ion binding]; other site
1423144011670	G-X-G motif; other site
1423144011671	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
1423144011672	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1423144011673	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144011674	active site
1423144011675	phosphorylation site [posttranslational modification]
1423144011676	intermolecular recognition site; other site
1423144011677	dimerization interface [polypeptide binding]; other site
1423144011678	STAS domain; Region: STAS_2; pfam13466
1423144011679	Cache domain; Region: Cache_1; pfam02743
1423144011680	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1423144011681	dimerization interface [polypeptide binding]; other site
1423144011682	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
1423144011683	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
1423144011684	dimer interface [polypeptide binding]; other site
1423144011685	putative CheW interface [polypeptide binding]; other site
1423144011686	CheB methylesterase; Region: CheB_methylest; pfam01339
1423144011687	CheD chemotactic sensory transduction; Region: CheD; cl00810
1423144011688	molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677
1423144011689	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
1423144011690	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
1423144011691	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144011692	putative PBP binding loops; other site
1423144011693	dimer interface [polypeptide binding]; other site
1423144011694	ABC-ATPase subunit interface; other site
1423144011695	ABC-type molybdate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: ModC; COG4148
1423144011696	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1423144011697	Walker A/P-loop; other site
1423144011698	ATP binding site [chemical binding]; other site
1423144011699	Q-loop/lid; other site
1423144011700	ABC transporter signature motif; other site
1423144011701	Walker B; other site
1423144011702	D-loop; other site
1423144011703	H-loop/switch region; other site
1423144011704	TOBE domain; Region: TOBE; cl01440
1423144011705	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1423144011706	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1423144011707	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1423144011708	intersubunit interface [polypeptide binding]; other site
1423144011709	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
1423144011710	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
1423144011711	metal binding site 2 [ion binding]; metal-binding site
1423144011712	putative DNA binding helix; other site
1423144011713	metal binding site 1 [ion binding]; metal-binding site
1423144011714	dimer interface [polypeptide binding]; other site
1423144011715	structural Zn2+ binding site [ion binding]; other site
1423144011716	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
1423144011717	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
1423144011718	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
1423144011719	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
1423144011720	ABC-ATPase subunit  interface; other site
1423144011721	dimer interface [polypeptide binding]; other site
1423144011722	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1423144011723	dimer interface [polypeptide binding]; other site
1423144011724	phosphorylation site [posttranslational modification]
1423144011725	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1423144011726	ATP binding site [chemical binding]; other site
1423144011727	Mg2+ binding site [ion binding]; other site
1423144011728	G-X-G motif; other site
1423144011729	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
1423144011730	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144011731	active site
1423144011732	phosphorylation site [posttranslational modification]
1423144011733	intermolecular recognition site; other site
1423144011734	dimerization interface [polypeptide binding]; other site
1423144011735	Response regulator receiver domain; Region: Response_reg; pfam00072
1423144011736	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144011737	active site
1423144011738	phosphorylation site [posttranslational modification]
1423144011739	intermolecular recognition site; other site
1423144011740	dimerization interface [polypeptide binding]; other site
1423144011741	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
1423144011742	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
1423144011743	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
1423144011744	active site residue [active]
1423144011745	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1423144011746	active site residue [active]
1423144011747	60Kd inner membrane protein; Region: 60KD_IMP; pfam02096
1423144011748	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
1423144011749	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
1423144011750	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1423144011751	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1423144011752	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1423144011753	putative active site [active]
1423144011754	Vi polysaccharide biosynthesis protein TviB; Provisional; Region: PRK15182
1423144011755	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1423144011756	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
1423144011757	N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834
1423144011758	Amidinotransferase; Region: Amidinotransf; cl12043
1423144011759	hypothetical protein; Provisional; Region: PRK07524
1423144011760	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
1423144011761	PYR/PP interface [polypeptide binding]; other site
1423144011762	dimer interface [polypeptide binding]; other site
1423144011763	TPP binding site [chemical binding]; other site
1423144011764	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
1423144011765	Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cd00568
1423144011766	TPP-binding site [chemical binding]; other site
1423144011767	Aspartate/tyrosine/aromatic aminotransferase [Amino acid transport and metabolism]; Region: COG0436
1423144011768	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
1423144011769	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144011770	homodimer interface [polypeptide binding]; other site
1423144011771	catalytic residue [active]
1423144011772	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1423144011773	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
1423144011774	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
1423144011775	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1423144011776	Walker A/P-loop; other site
1423144011777	ATP binding site [chemical binding]; other site
1423144011778	Q-loop/lid; other site
1423144011779	ABC transporter signature motif; other site
1423144011780	Walker B; other site
1423144011781	D-loop; other site
1423144011782	H-loop/switch region; other site
1423144011783	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
1423144011784	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1423144011785	substrate binding pocket [chemical binding]; other site
1423144011786	membrane-bound complex binding site; other site
1423144011787	hinge residues; other site
1423144011788	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1423144011789	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144011790	dimer interface [polypeptide binding]; other site
1423144011791	conserved gate region; other site
1423144011792	putative PBP binding loops; other site
1423144011793	ABC-ATPase subunit interface; other site
1423144011794	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
1423144011795	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144011796	dimer interface [polypeptide binding]; other site
1423144011797	conserved gate region; other site
1423144011798	putative PBP binding loops; other site
1423144011799	ABC-ATPase subunit interface; other site
1423144011800	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
1423144011801	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1423144011802	DNA binding residues [nucleotide binding]
1423144011803	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1423144011804	P-loop; other site
1423144011805	Magnesium ion binding site [ion binding]; other site
1423144011806	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1423144011807	Magnesium ion binding site [ion binding]; other site
1423144011808	plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454
1423144011809	ParB-like nuclease domain; Region: ParB; smart00470
1423144011810	replication initiation protein RepC; Provisional; Region: PRK13824
1423144011811	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1423144011812	putative DNA binding site [nucleotide binding]; other site
1423144011813	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
1423144011814	Predicted alpha/beta hydrolase [General function prediction only]; Region: COG4757
1423144011815	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1423144011816	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1423144011817	CcdB protein; Region: CcdB; cl03380
1423144011818	Post-segregation antitoxin CcdA; Region: CcdA; pfam07362
1423144011819	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
1423144011820	XdhC Rossmann domain; Region: XdhC_C; pfam13478
1423144011821	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1423144011822	Predicted transcriptional regulators [Transcription]; Region: COG1733
1423144011823	HxlR-like helix-turn-helix; Region: HxlR; pfam01638
1423144011824	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
1423144011825	Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408
1423144011826	inhibitor site; inhibition site
1423144011827	active site
1423144011828	dimer interface [polypeptide binding]; other site
1423144011829	catalytic residue [active]
1423144011830	L-aspartate dehydrogenase; Provisional; Region: PRK13303
1423144011831	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
1423144011832	Domain of unknown function DUF108; Region: DUF108; pfam01958
1423144011833	pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424
1423144011834	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144011835	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1423144011836	dimerization interface [polypeptide binding]; other site
1423144011837	DctM-like transporters; Region: DctM; pfam06808
1423144011838	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
1423144011839	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
1423144011840	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
1423144011841	Tripartite tricarboxylate transporter TctA family; Region: TctA; pfam01970
1423144011842	Tripartite tricarboxylate transporter family receptor; Region: TctC; cl17792
1423144011843	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
1423144011844	kynureninase; Region: kynureninase; TIGR01814
1423144011845	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
1423144011846	catalytic residue [active]
1423144011847	DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534
1423144011848	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
1423144011849	DNA-binding site [nucleotide binding]; DNA binding site
1423144011850	FCD domain; Region: FCD; pfam07729
1423144011851	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1423144011852	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1423144011853	tetramerization interface [polypeptide binding]; other site
1423144011854	NAD(P) binding site [chemical binding]; other site
1423144011855	catalytic residues [active]
1423144011856	3-hydroxyanthranilic acid dioxygenase; Region: 3-HAO; cl17399
1423144011857	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1423144011858	DNA binding site [nucleotide binding]
1423144011859	Predicted integral membrane protein [Function unknown]; Region: COG5616
1423144011860	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1423144011861	binding surface
1423144011862	TPR motif; other site
1423144011863	TPR repeat; Region: TPR_11; pfam13414
1423144011864	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474
1423144011865	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
1423144011866	active site
1423144011867	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
1423144011868	active site
1423144011869	catalytic residues [active]
1423144011870	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
1423144011871	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
1423144011872	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
1423144011873	putative active site [active]
1423144011874	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
1423144011875	DctM-like transporters; Region: DctM; pfam06808
1423144011876	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
1423144011877	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
1423144011878	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
1423144011879	Uncharacterized conserved protein [Function unknown]; Region: COG5476
1423144011880	Protein of unknown function (DUF1485); Region: DUF1485; pfam07364
1423144011881	MlrC C-terminus; Region: MlrC_C; pfam07171
1423144011882	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Low Specificity D-Threonine Aldolase-like; Region: PLPDE_III_LS_D-TA_like; cd06820
1423144011883	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
1423144011884	dimer interface [polypeptide binding]; other site
1423144011885	active site
1423144011886	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
1423144011887	substrate binding site [chemical binding]; other site
1423144011888	catalytic residue [active]
1423144011889	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
1423144011890	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
1423144011891	substrate binding site [chemical binding]; other site
1423144011892	ATP binding site [chemical binding]; other site
1423144011893	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
1423144011894	homotrimer interaction site [polypeptide binding]; other site
1423144011895	putative active site [active]
1423144011896	Integrase core domain; Region: rve_3; pfam13683
1423144011897	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1423144011898	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144011899	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
1423144011900	dimerization interface [polypeptide binding]; other site
1423144011901	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
1423144011902	active site
1423144011903	intersubunit interface [polypeptide binding]; other site
1423144011904	Zn2+ binding site [ion binding]; other site
1423144011905	salicylate hydroxylase; Provisional; Region: PRK08163
1423144011906	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1423144011907	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1423144011908	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1423144011909	maleylacetoacetate isomerase; Region: maiA; TIGR01262
1423144011910	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
1423144011911	C-terminal domain interface [polypeptide binding]; other site
1423144011912	GSH binding site (G-site) [chemical binding]; other site
1423144011913	putative dimer interface [polypeptide binding]; other site
1423144011914	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
1423144011915	N-terminal domain interface [polypeptide binding]; other site
1423144011916	dimer interface [polypeptide binding]; other site
1423144011917	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
1423144011918	Gentisate 1,2-dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3435
1423144011919	Cupin domain; Region: Cupin_2; pfam07883
1423144011920	Mycothiol maleylpyruvate isomerase N-terminal domain; Region: MDMPI_N; pfam11716
1423144011921	Transcriptional regulators [Transcription]; Region: MarR; COG1846
1423144011922	MarR family; Region: MarR_2; pfam12802
1423144011923	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1423144011924	Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596
1423144011925	active site
1423144011926	intersubunit interface [polypeptide binding]; other site
1423144011927	Zn2+ binding site [ion binding]; other site
1423144011928	homogentisate 1,2-dioxygenase; Region: HgmA; cl17306
1423144011929	Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064
1423144011930	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
1423144011931	NAD(P) binding site [chemical binding]; other site
1423144011932	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
1423144011933	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
1423144011934	hypothetical protein; Provisional; Region: PRK07236
1423144011935	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1423144011936	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
1423144011937	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
1423144011938	Glyoxalase-like domain; Region: Glyoxalase_2; pfam12681
1423144011939	C-terminal domain of type I, class II extradiol dioxygenases; catalytic domain; Region: ED_TypeI_classII_C; cd08343
1423144011940	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1423144011941	active site
1423144011942	metal binding site [ion binding]; metal-binding site
1423144011943	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1423144011944	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1423144011945	putative DNA binding site [nucleotide binding]; other site
1423144011946	putative Zn2+ binding site [ion binding]; other site
1423144011947	Bacterial transcriptional regulator; Region: IclR; pfam01614
1423144011948	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
1423144011949	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
1423144011950	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
1423144011951	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_2; pfam07992
1423144011952	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1423144011953	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1423144011954	SCP-2 sterol transfer family; Region: SCP2; pfam02036
1423144011955	3-hydroxyanthranilic acid dioxygenase; Region: 3-HAO; cl17399
1423144011956	3-hydroxyanthranilic acid dioxygenase; Region: 3-HAO; cl17399
1423144011957	Transcriptional regulator [Transcription]; Region: IclR; COG1414
1423144011958	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
1423144011959	Bacterial transcriptional regulator; Region: IclR; pfam01614
1423144011960	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1423144011961	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
1423144011962	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
1423144011963	putative active site [active]
1423144011964	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
1423144011965	DctM-like transporters; Region: DctM; pfam06808
1423144011966	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
1423144011967	Prokaryotic protein of unknown function (DUF849); Region: DUF849; pfam05853
1423144011968	Hydroxyquinol 1,2-dioxygenase (1,2-HQD) catalyzes the ring cleavage of hydroxyquinol (1,2,4-trihydroxybenzene), a intermediate in the degradation of a large variety of aromatic compounds including some polychloro- and nitroaromatic pollutants, to form...; Region: 1,2-HQD; cd03461
1423144011969	chlorocatechol 1,2-dioxygenase; Region: chlorocat_1_2; TIGR02465
1423144011970	dimer interface [polypeptide binding]; other site
1423144011971	active site
1423144011972	Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581
1423144011973	ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177
1423144011974	TM-ABC transporter signature motif; other site
1423144011975	Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582
1423144011976	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1423144011977	TM-ABC transporter signature motif; other site
1423144011978	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410
1423144011979	ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224
1423144011980	Walker A/P-loop; other site
1423144011981	ATP binding site [chemical binding]; other site
1423144011982	Q-loop/lid; other site
1423144011983	ABC transporter signature motif; other site
1423144011984	Walker B; other site
1423144011985	D-loop; other site
1423144011986	H-loop/switch region; other site
1423144011987	ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411
1423144011988	ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219
1423144011989	Walker A/P-loop; other site
1423144011990	ATP binding site [chemical binding]; other site
1423144011991	Q-loop/lid; other site
1423144011992	ABC transporter signature motif; other site
1423144011993	Walker B; other site
1423144011994	D-loop; other site
1423144011995	H-loop/switch region; other site
1423144011996	Periplasmic binding protein; Region: Peripla_BP_6; pfam13458
1423144011997	Type I periplasmic ligand-binding domain of uncharacterized ABC (ATPase Binding Cassette)-type active transport systems that are predicted to be involved in transport of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_ligand_binding_like_4; cd06337
1423144011998	putative ligand binding site [chemical binding]; other site
1423144011999	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
1423144012000	Maleylacetate reductase is involved in many aromatic compounds degradation pathways of aerobic microbes; Region: MAR; cd08177
1423144012001	active site
1423144012002	dimer interface [polypeptide binding]; other site
1423144012003	metal binding site [ion binding]; metal-binding site
1423144012004	3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183
1423144012005	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1423144012006	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
1423144012007	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1423144012008	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1423144012009	DDE domain; Region: DDE_Tnp_IS240; pfam13610
1423144012010	Transposase; Region: HTH_Tnp_1; pfam01527
1423144012011	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
1423144012012	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1423144012013	Major Facilitator Superfamily; Region: MFS_1; pfam07690
1423144012014	putative substrate translocation pore; other site
1423144012015	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
1423144012016	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
1423144012017	FAD binding pocket [chemical binding]; other site
1423144012018	FAD binding motif [chemical binding]; other site
1423144012019	phosphate binding motif [ion binding]; other site
1423144012020	beta-alpha-beta structure motif; other site
1423144012021	NAD binding pocket [chemical binding]; other site
1423144012022	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
1423144012023	catalytic loop [active]
1423144012024	iron binding site [ion binding]; other site
1423144012025	Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638
1423144012026	Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469
1423144012027	[2Fe-2S] cluster binding site [ion binding]; other site
1423144012028	C-terminal catalytic domain of GbcA (glycine betaine catabolism A) from Pseudomonas aeruginosa PAO1 and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_GbcA-like; cd08884
1423144012029	putative alpha subunit interface [polypeptide binding]; other site
1423144012030	putative active site [active]
1423144012031	putative substrate binding site [chemical binding]; other site
1423144012032	Fe binding site [ion binding]; other site
1423144012033	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1423144012034	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144012035	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1423144012036	putative effector binding pocket; other site
1423144012037	dimerization interface [polypeptide binding]; other site
1423144012038	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
1423144012039	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
1423144012040	putative NAD(P) binding site [chemical binding]; other site
1423144012041	dimer interface [polypeptide binding]; other site
1423144012042	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199
1423144012043	homotrimer interaction site [polypeptide binding]; other site
1423144012044	putative active site [active]
1423144012045	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
1423144012046	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; cl17891
1423144012047	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1423144012048	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1423144012049	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144012050	dimer interface [polypeptide binding]; other site
1423144012051	conserved gate region; other site
1423144012052	putative PBP binding loops; other site
1423144012053	ABC-ATPase subunit interface; other site
1423144012054	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1423144012055	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144012056	dimer interface [polypeptide binding]; other site
1423144012057	conserved gate region; other site
1423144012058	putative PBP binding loops; other site
1423144012059	ABC-ATPase subunit interface; other site
1423144012060	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1423144012061	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
1423144012062	Walker A/P-loop; other site
1423144012063	ATP binding site [chemical binding]; other site
1423144012064	Q-loop/lid; other site
1423144012065	ABC transporter signature motif; other site
1423144012066	Walker B; other site
1423144012067	D-loop; other site
1423144012068	H-loop/switch region; other site
1423144012069	TOBE domain; Region: TOBE; pfam03459
1423144012070	TOBE domain; Region: TOBE_2; pfam08402
1423144012071	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1423144012072	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1423144012073	Walker A/P-loop; other site
1423144012074	ATP binding site [chemical binding]; other site
1423144012075	Q-loop/lid; other site
1423144012076	ABC transporter signature motif; other site
1423144012077	Walker B; other site
1423144012078	D-loop; other site
1423144012079	H-loop/switch region; other site
1423144012080	TOBE domain; Region: TOBE_2; pfam08402
1423144012081	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1423144012082	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144012083	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
1423144012084	putative effector binding pocket; other site
1423144012085	dimerization interface [polypeptide binding]; other site
1423144012086	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
1423144012087	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
1423144012088	FMN binding site [chemical binding]; other site
1423144012089	active site
1423144012090	substrate binding site [chemical binding]; other site
1423144012091	catalytic residue [active]
1423144012092	O-acetylserine/cysteine export protein; Provisional; Region: PRK11453
1423144012093	EamA-like transporter family; Region: EamA; pfam00892
1423144012094	EamA-like transporter family; Region: EamA; pfam00892
1423144012095	short chain dehydrogenase; Provisional; Region: PRK07041
1423144012096	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1423144012097	NAD(P) binding site [chemical binding]; other site
1423144012098	active site
1423144012099	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
1423144012100	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245
1423144012101	dimer interface [polypeptide binding]; other site
1423144012102	putative metal binding site [ion binding]; other site
1423144012103	Cupin domain; Region: Cupin_2; pfam07883
1423144012104	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
1423144012105	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
1423144012106	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
1423144012107	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; cl17274
1423144012108	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1423144012109	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1423144012110	Initiator Replication protein; Region: Rep_3; pfam01051
1423144012111	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
1423144012112	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1423144012113	P-loop; other site
1423144012114	Magnesium ion binding site [ion binding]; other site
1423144012115	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1423144012116	Magnesium ion binding site [ion binding]; other site
1423144012117	ParB-like nuclease domain; Region: ParB; smart00470
1423144012118	PRC-barrel domain; Region: PRC; pfam05239
1423144012119	PRC-barrel domain; Region: PRC; pfam05239
1423144012120	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1423144012121	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1423144012122	substrate binding pocket [chemical binding]; other site
1423144012123	membrane-bound complex binding site; other site
1423144012124	hinge residues; other site
1423144012125	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1423144012126	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1423144012127	dimer interface [polypeptide binding]; other site
1423144012128	phosphorylation site [posttranslational modification]
1423144012129	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1423144012130	ATP binding site [chemical binding]; other site
1423144012131	Mg2+ binding site [ion binding]; other site
1423144012132	G-X-G motif; other site
1423144012133	Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814
1423144012134	putative hydrophobic ligand binding site [chemical binding]; other site
1423144012135	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
1423144012136	dimerization interface [polypeptide binding]; other site
1423144012137	putative DNA binding site [nucleotide binding]; other site
1423144012138	putative Zn2+ binding site [ion binding]; other site
1423144012139	MltA-interacting protein MipA; Region: MipA; cl01504
1423144012140	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
1423144012141	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
1423144012142	HlyD family secretion protein; Region: HlyD_3; pfam13437
1423144012143	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
1423144012144	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
1423144012145	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
1423144012146	Autoinducer binding domain; Region: Autoind_bind; pfam03472
1423144012147	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1423144012148	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1423144012149	DNA binding residues [nucleotide binding]
1423144012150	dimerization interface [polypeptide binding]; other site
1423144012151	Fic family protein [Function unknown]; Region: COG3177
1423144012152	Domain of unknown function (DUF4172); Region: DUF4172; pfam13776
1423144012153	Fic/DOC family; Region: Fic; pfam02661
1423144012154	MarR family; Region: MarR_2; cl17246
1423144012155	Uncharacterized protein conserved in bacteria (DUF2218); Region: DUF2218; pfam09981
1423144012156	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1423144012157	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1423144012158	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1423144012159	Walker A/P-loop; other site
1423144012160	ATP binding site [chemical binding]; other site
1423144012161	Q-loop/lid; other site
1423144012162	ABC transporter signature motif; other site
1423144012163	Walker B; other site
1423144012164	D-loop; other site
1423144012165	H-loop/switch region; other site
1423144012166	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1423144012167	acyl carrier protein; Provisional; Region: PRK07639
1423144012168	acyl-CoA synthetase; Validated; Region: PRK08308
1423144012169	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1423144012170	acyl-activating enzyme (AAE) consensus motif; other site
1423144012171	AMP binding site [chemical binding]; other site
1423144012172	active site
1423144012173	CoA binding site [chemical binding]; other site
1423144012174	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1423144012175	IucA / IucC family; Region: IucA_IucC; pfam04183
1423144012176	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1423144012177	Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264
1423144012178	IucA / IucC family; Region: IucA_IucC; pfam04183
1423144012179	Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276
1423144012180	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
1423144012181	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
1423144012182	Siderophore binding protein FatB.  These proteins have been shown to function as ABC-type initial receptors in the siderophore-mediated iron uptake in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins...; Region: FatB; cd01140
1423144012183	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
1423144012184	putative ligand binding residues [chemical binding]; other site
1423144012185	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1423144012186	ABC-ATPase subunit  interface; other site
1423144012187	dimer interface [polypeptide binding]; other site
1423144012188	putative PBP binding regions; other site
1423144012189	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
1423144012190	ABC-ATPase subunit  interface; other site
1423144012191	dimer interface [polypeptide binding]; other site
1423144012192	putative PBP binding regions; other site
1423144012193	ABC-type enterochelin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CeuD; COG4604
1423144012194	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
1423144012195	Walker A/P-loop; other site
1423144012196	ATP binding site [chemical binding]; other site
1423144012197	Q-loop/lid; other site
1423144012198	ABC transporter signature motif; other site
1423144012199	Walker B; other site
1423144012200	D-loop; other site
1423144012201	H-loop/switch region; other site
1423144012202	putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329
1423144012203	Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665
1423144012204	Domain of unknown function (DUF4345); Region: DUF4345; pfam14248
1423144012205	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
1423144012206	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
1423144012207	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
1423144012208	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1423144012209	conserved cys residue [active]
1423144012210	glycine dehydrogenase; Provisional; Region: PRK05367
1423144012211	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1423144012212	tetramer interface [polypeptide binding]; other site
1423144012213	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144012214	catalytic residue [active]
1423144012215	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
1423144012216	tetramer interface [polypeptide binding]; other site
1423144012217	pyridoxal 5'-phosphate binding site [chemical binding]; other site
1423144012218	catalytic residue [active]
1423144012219	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
1423144012220	lipoyl attachment site [posttranslational modification]; other site
1423144012221	glycine cleavage system aminomethyltransferase T; Provisional; Region: gcvT; PRK13579
1423144012222	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
1423144012223	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
1423144012224	amino acid carrier protein; Region: agcS; TIGR00835
1423144012225	lipoyl synthase; Provisional; Region: PRK05481
1423144012226	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
1423144012227	FeS/SAM binding site; other site
1423144012228	dihydrolipoamide dehydrogenase; Validated; Region: PRK06327
1423144012229	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1423144012230	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1423144012231	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1423144012232	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1423144012233	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1423144012234	non-specific DNA binding site [nucleotide binding]; other site
1423144012235	salt bridge; other site
1423144012236	sequence-specific DNA binding site [nucleotide binding]; other site
1423144012237	Cupin domain; Region: Cupin_2; pfam07883
1423144012238	Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070
1423144012239	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3002
1423144012240	NADH dehydrogenase subunit L; Provisional; Region: PRK08168
1423144012241	NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361
1423144012242	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1423144012243	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144012244	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
1423144012245	dimerization interface [polypeptide binding]; other site
1423144012246	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1423144012247	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1423144012248	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1423144012249	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1423144012250	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
1423144012251	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
1423144012252	Walker A/P-loop; other site
1423144012253	ATP binding site [chemical binding]; other site
1423144012254	Q-loop/lid; other site
1423144012255	ABC transporter signature motif; other site
1423144012256	Walker B; other site
1423144012257	D-loop; other site
1423144012258	H-loop/switch region; other site
1423144012259	TOBE domain; Region: TOBE_2; pfam08402
1423144012260	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
1423144012261	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144012262	dimer interface [polypeptide binding]; other site
1423144012263	conserved gate region; other site
1423144012264	putative PBP binding loops; other site
1423144012265	ABC-ATPase subunit interface; other site
1423144012266	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
1423144012267	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144012268	dimer interface [polypeptide binding]; other site
1423144012269	conserved gate region; other site
1423144012270	putative PBP binding loops; other site
1423144012271	ABC-ATPase subunit interface; other site
1423144012272	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1423144012273	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
1423144012274	Transcriptional regulators [Transcription]; Region: PurR; COG1609
1423144012275	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
1423144012276	DNA binding site [nucleotide binding]
1423144012277	domain linker motif; other site
1423144012278	Ligand-binding domain of DNA transcription repressors specific for raffinose (RafR) and alpha-glucosides (AglR) which are members of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_AglR_RafR_like; cd06271
1423144012279	ligand binding site [chemical binding]; other site
1423144012280	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
1423144012281	AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582
1423144012282	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
1423144012283	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
1423144012284	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
1423144012285	Rhodococcus ruber 6-oxolauric acid dehydrogenase-like; Region: ALDH_CddD_SSP0762; cd07138
1423144012286	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1423144012287	NAD binding site [chemical binding]; other site
1423144012288	catalytic residues [active]
1423144012289	H+ Antiporter protein; Region: 2A0121; TIGR00900
1423144012290	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
1423144012291	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
1423144012292	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
1423144012293	heme-binding site [chemical binding]; other site
1423144012294	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
1423144012295	FAD binding pocket [chemical binding]; other site
1423144012296	FAD binding motif [chemical binding]; other site
1423144012297	phosphate binding motif [ion binding]; other site
1423144012298	beta-alpha-beta structure motif; other site
1423144012299	NAD binding pocket [chemical binding]; other site
1423144012300	Heme binding  pocket [chemical binding]; other site
1423144012301	Transcriptional regulator; Region: Rrf2; cl17282
1423144012302	Rrf2 family protein; Region: rrf2_super; TIGR00738
1423144012303	Predicted transmembrane transcriptional regulator (anti-sigma factor) [Transcription]; Region: COG5662
1423144012304	RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937
1423144012305	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
1423144012306	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
1423144012307	DNA binding residues [nucleotide binding]
1423144012308	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
1423144012309	Secreted repeat of unknown function; Region: Lipoprotein_15; pfam03640
1423144012310	catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061
1423144012311	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
1423144012312	heme binding site [chemical binding]; other site
1423144012313	Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196
1423144012314	heme binding site [chemical binding]; other site
1423144012315	Transcriptional regulator [Transcription]; Region: LysR; COG0583
1423144012316	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
1423144012317	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
1423144012318	dimerization interface [polypeptide binding]; other site
1423144012319	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
1423144012320	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1423144012321	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1423144012322	Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661
1423144012323	ABC1 family; Region: ABC1; pfam03109
1423144012324	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
1423144012325	Protein of unknown function (DUF3800); Region: DUF3800; pfam12686
1423144012326	Protein of unknown function DUF262; Region: DUF262; pfam03235
1423144012327	Uncharacterized conserved protein [Function unknown]; Region: COG1479
1423144012328	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
1423144012329	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1423144012330	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1423144012331	non-specific DNA binding site [nucleotide binding]; other site
1423144012332	salt bridge; other site
1423144012333	sequence-specific DNA binding site [nucleotide binding]; other site
1423144012334	Protein of unknown function (DUF3768); Region: DUF3768; pfam12599
1423144012335	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
1423144012336	ParB-like nuclease domain; Region: ParBc; pfam02195
1423144012337	Rv0623-like transcription factor; Region: PSK_trans_fac; pfam07704
1423144012338	PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812
1423144012339	putative active site [active]
1423144012340	Uncharacterized ACR, COG1430; Region: DUF192; pfam02643
1423144012341	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075
1423144012342	Mg2+ binding site [ion binding]; other site
1423144012343	G-X-G motif; other site
1423144012344	Predicted helicase [General function prediction only]; Region: COG4889
1423144012345	Restriction endonuclease; Region: Mrr_cat_2; pfam13156
1423144012346	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
1423144012347	ATP binding site [chemical binding]; other site
1423144012348	putative Mg++ binding site [ion binding]; other site
1423144012349	helicase superfamily c-terminal domain; Region: HELICc; smart00490
1423144012350	nucleotide binding region [chemical binding]; other site
1423144012351	ATP-binding site [chemical binding]; other site
1423144012352	Predicted transcriptional regulator [Transcription]; Region: COG3636; cl17681
1423144012353	putative addiction module killer protein; Region: upstrm_HI1419; TIGR02683
1423144012354	Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020
1423144012355	3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084
1423144012356	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
1423144012357	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
1423144012358	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
1423144012359	Walker A/P-loop; other site
1423144012360	ATP binding site [chemical binding]; other site
1423144012361	Q-loop/lid; other site
1423144012362	ABC transporter signature motif; other site
1423144012363	Walker B; other site
1423144012364	D-loop; other site
1423144012365	H-loop/switch region; other site
1423144012366	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
1423144012367	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1423144012368	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1423144012369	TM-ABC transporter signature motif; other site
1423144012370	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
1423144012371	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
1423144012372	TM-ABC transporter signature motif; other site
1423144012373	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1423144012374	acetoin reductases; Region: 23BDH; TIGR02415
1423144012375	NAD(P) binding site [chemical binding]; other site
1423144012376	active site
1423144012377	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_8; cd06317
1423144012378	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
1423144012379	putative ligand binding site [chemical binding]; other site
1423144012380	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
1423144012381	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
1423144012382	sorbitol dehydrogenase; Provisional; Region: PRK07067
1423144012383	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1423144012384	NAD(P) binding site [chemical binding]; other site
1423144012385	active site
1423144012386	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
1423144012387	A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066
1423144012388	active site
1423144012389	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
1423144012390	tetramer interface [polypeptide binding]; other site
1423144012391	TPP-binding site [chemical binding]; other site
1423144012392	heterodimer interface [polypeptide binding]; other site
1423144012393	phosphorylation loop region [posttranslational modification]
1423144012394	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
1423144012395	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
1423144012396	alpha subunit interface [polypeptide binding]; other site
1423144012397	TPP binding site [chemical binding]; other site
1423144012398	heterodimer interface [polypeptide binding]; other site
1423144012399	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
1423144012400	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1423144012401	E3 interaction surface; other site
1423144012402	Biotin carboxyl carrier protein [Lipid metabolism]; Region: AccB; COG0511
1423144012403	lipoyl attachment site [posttranslational modification]; other site
1423144012404	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508
1423144012405	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1423144012406	E3 interaction surface; other site
1423144012407	lipoyl attachment site [posttranslational modification]; other site
1423144012408	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
1423144012409	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
1423144012410	tetramerization interface [polypeptide binding]; other site
1423144012411	NAD(P) binding site [chemical binding]; other site
1423144012412	catalytic residues [active]
1423144012413	dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857
1423144012414	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
1423144012415	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
1423144012416	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
1423144012417	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1423144012418	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1423144012419	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
1423144012420	hydrogenase nickel incorporation protein; Provisional; Region: hypA; PRK00564
1423144012421	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
1423144012422	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
1423144012423	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
1423144012424	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1423144012425	P-loop; other site
1423144012426	Magnesium ion binding site [ion binding]; other site
1423144012427	Helix-turn-helix domain; Region: HTH_38; pfam13936
1423144012428	type IV secretion system T-DNA border endonuclease VirD2; Provisional; Region: PRK13863
1423144012429	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
1423144012430	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1423144012431	Walker A motif; other site
1423144012432	ATP binding site [chemical binding]; other site
1423144012433	Walker B motif; other site
1423144012434	Zeta toxin; Region: Zeta_toxin; pfam06414
1423144012435	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4185
1423144012436	Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267
1423144012437	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
1423144012438	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
1423144012439	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
1423144012440	ATP binding site [chemical binding]; other site
1423144012441	Walker A motif; other site
1423144012442	hexamer interface [polypeptide binding]; other site
1423144012443	Walker B motif; other site
1423144012444	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
1423144012445	Type IV secretory pathway, VirB9 components [Intracellular trafficking and secretion]; Region: VirB9; COG3504
1423144012446	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
1423144012447	VirB7 interaction site; other site
1423144012448	VirB8 protein; Region: VirB8; pfam04335
1423144012449	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
1423144012450	conjugal transfer protein TrbJ; Provisional; Region: PRK13874; cl02193
1423144012451	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1423144012452	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1423144012453	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1423144012454	catalytic residue [active]
1423144012455	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
1423144012456	type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929
1423144012457	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
1423144012458	Domain of unknown function DUF87; Region: DUF87; pfam01935
1423144012459	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
1423144012460	Walker B motif; other site
1423144012461	TrbC/VIRB2 family; Region: TrbC; pfam04956
1423144012462	Replication initiator protein A; Region: RPA; pfam10134
1423144012463	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
1423144012464	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1423144012465	P-loop; other site
1423144012466	Magnesium ion binding site [ion binding]; other site
1423144012467	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1423144012468	Magnesium ion binding site [ion binding]; other site
1423144012469	plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454
1423144012470	ParB-like nuclease domain; Region: ParBc; cl02129
1423144012471	Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004
1423144012472	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
1423144012473	UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720
1423144012474	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
1423144012475	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
1423144012476	putative NAD(P) binding site [chemical binding]; other site
1423144012477	active site
1423144012478	putative substrate binding site [chemical binding]; other site
1423144012479	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1423144012480	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
1423144012481	active site
1423144012482	ABC-2 type transporter; Region: ABC2_membrane; cl17235
1423144012483	Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsE; COG3524
1423144012484	ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555
1423144012485	ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220
1423144012486	Walker A/P-loop; other site
1423144012487	ATP binding site [chemical binding]; other site
1423144012488	Q-loop/lid; other site
1423144012489	ABC transporter signature motif; other site
1423144012490	Walker B; other site
1423144012491	D-loop; other site
1423144012492	H-loop/switch region; other site
1423144012493	UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562
1423144012494	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
1423144012495	UDP-galactopyranose mutase; Region: GLF; pfam03275
1423144012496	Predicted glycosyltransferases [General function prediction only]; Region: COG1216
1423144012497	Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_b; cd04185
1423144012498	Probable Catalytic site; other site
1423144012499	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1423144012500	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
1423144012501	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
1423144012502	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
1423144012503	Sulfotransferase family; Region: Sulfotransfer_2; pfam03567
1423144012504	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
1423144012505	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
1423144012506	Walker A/P-loop; other site
1423144012507	ATP binding site [chemical binding]; other site
1423144012508	Q-loop/lid; other site
1423144012509	ABC transporter signature motif; other site
1423144012510	Walker B; other site
1423144012511	D-loop; other site
1423144012512	H-loop/switch region; other site
1423144012513	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1423144012514	HlyD family secretion protein; Region: HlyD_3; pfam13437
1423144012515	GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089
1423144012516	GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260
1423144012517	NADP-binding site; other site
1423144012518	homotetramer interface [polypeptide binding]; other site
1423144012519	substrate binding site [chemical binding]; other site
1423144012520	homodimer interface [polypeptide binding]; other site
1423144012521	active site
1423144012522	GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239
1423144012523	GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725
1423144012524	NADP binding site [chemical binding]; other site
1423144012525	active site
1423144012526	putative substrate binding site [chemical binding]; other site
1423144012527	mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase; Region: GMP_PMI; TIGR01479
1423144012528	GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509
1423144012529	Substrate binding site; other site
1423144012530	Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050
1423144012531	Protein of unknown function (DUF2793); Region: DUF2793; pfam10983
1423144012532	Peptidase_G2, IMC autoproteolytic cleavage domain; Region: Peptidase_G2; pfam11962
1423144012533	Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064
1423144012534	active site
1423144012535	Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548
1423144012536	dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908
1423144012537	dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088
1423144012538	dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246
1423144012539	NAD binding site [chemical binding]; other site
1423144012540	substrate binding site [chemical binding]; other site
1423144012541	homodimer interface [polypeptide binding]; other site
1423144012542	active site
1423144012543	dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254
1423144012544	RmlD substrate binding domain; Region: RmlD_sub_bind; pfam04321
1423144012545	NADP binding site [chemical binding]; other site
1423144012546	active site
1423144012547	putative substrate binding site [chemical binding]; other site
1423144012548	G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538
1423144012549	glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207
1423144012550	substrate binding site; other site
1423144012551	tetramer interface; other site
1423144012552	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
1423144012553	trimer interface [polypeptide binding]; other site
1423144012554	active site
1423144012555	substrate binding site [chemical binding]; other site
1423144012556	CoA binding site [chemical binding]; other site
1423144012557	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
1423144012558	Periplasmic protein involved in polysaccharide export, contains    SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596
1423144012559	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
1423144012560	active site
1423144012561	Bacterial sugar transferase; Region: Bac_transf; pfam02397
1423144012562	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
1423144012563	Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719
1423144012564	NAD(P) binding site [chemical binding]; other site
1423144012565	homodimer interface [polypeptide binding]; other site
1423144012566	substrate binding site [chemical binding]; other site
1423144012567	active site
1423144012568	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
1423144012569	Protein of unknown function (DUF2886); Region: DUF2886; pfam11102
1423144012570	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
1423144012571	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
1423144012572	Walker A/P-loop; other site
1423144012573	ATP binding site [chemical binding]; other site
1423144012574	Q-loop/lid; other site
1423144012575	ABC transporter signature motif; other site
1423144012576	Walker B; other site
1423144012577	D-loop; other site
1423144012578	H-loop/switch region; other site
1423144012579	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
1423144012580	dimer interface [polypeptide binding]; other site
1423144012581	conserved gate region; other site
1423144012582	putative PBP binding loops; other site
1423144012583	ABC-ATPase subunit interface; other site
1423144012584	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
1423144012585	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
1423144012586	substrate binding pocket [chemical binding]; other site
1423144012587	membrane-bound complex binding site; other site
1423144012588	hinge residues; other site
1423144012589	Condensation domain; Region: Condensation; pfam00668
1423144012590	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
1423144012591	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
1423144012592	acyl-activating enzyme (AAE) consensus motif; other site
1423144012593	AMP binding site [chemical binding]; other site
1423144012594	active site
1423144012595	CoA binding site [chemical binding]; other site
1423144012596	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
1423144012597	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
1423144012598	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
1423144012599	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
1423144012600	This family is most closely related to the GT1 family of glycosyltransferases. ExpC in Rhizobium meliloti has been shown to be involved in the biosynthesis of galactoglucan (exopolysaccharide II); Region: GT1_ExpC_like; cd03818
1423144012601	putative ADP-binding pocket [chemical binding]; other site
1423144012602	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
1423144012603	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1423144012604	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1423144012605	DNA binding residues [nucleotide binding]
1423144012606	dimerization interface [polypeptide binding]; other site
1423144012607	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
1423144012608	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1423144012609	DNA binding residues [nucleotide binding]
1423144012610	dimerization interface [polypeptide binding]; other site
1423144012611	RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931
1423144012612	ABC-type protease/lipase transport system, ATPase and permease components [General function prediction only]; Region: ArpD; COG4618
1423144012613	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
1423144012614	Walker A/P-loop; other site
1423144012615	ATP binding site [chemical binding]; other site
1423144012616	Q-loop/lid; other site
1423144012617	ABC transporter signature motif; other site
1423144012618	Walker B; other site
1423144012619	D-loop; other site
1423144012620	H-loop/switch region; other site
1423144012621	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
1423144012622	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
1423144012623	HlyD family secretion protein; Region: HlyD_3; pfam13437
1423144012624	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
1423144012625	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1423144012626	DNA binding residues [nucleotide binding]
1423144012627	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1423144012628	P-loop; other site
1423144012629	Magnesium ion binding site [ion binding]; other site
1423144012630	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1423144012631	Magnesium ion binding site [ion binding]; other site
1423144012632	plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454
1423144012633	ParB-like nuclease domain; Region: ParBc; pfam02195
1423144012634	Replication protein C N-terminal domain; Region: RP-C; pfam03428
1423144012635	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1423144012636	non-specific DNA binding site [nucleotide binding]; other site
1423144012637	salt bridge; other site
1423144012638	sequence-specific DNA binding site [nucleotide binding]; other site
1423144012639	Domain of unknown function (DUF1983); Region: DUF1983; pfam09327
1423144012640	NlpC/P60 family; Region: NLPC_P60; cl17555
1423144012641	Domain of unknown function (DUF1833); Region: DUF1833; pfam08875
1423144012642	tape measure domain; Region: tape_meas_nterm; TIGR02675
1423144012643	Phage-related minor tail protein [Function unknown]; Region: COG5281
1423144012644	Phage head-tail joining protein; Region: Phage_H_T_join; cl11461
1423144012645	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
1423144012646	oligomerization interface [polypeptide binding]; other site
1423144012647	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
1423144012648	Phage capsid family; Region: Phage_capsid; pfam05065
1423144012649	Clp protease; Region: CLP_protease; pfam00574
1423144012650	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
1423144012651	oligomer interface [polypeptide binding]; other site
1423144012652	active site residues [active]
1423144012653	Phage-related protein [Function unknown]; Region: COG4695; cl01923
1423144012654	Phage portal protein; Region: Phage_portal; pfam04860
1423144012655	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
1423144012656	Homeodomain-like domain; Region: HTH_23; cl17451
1423144012657	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1423144012658	AAA domain; Region: AAA_23; pfam13476
1423144012659	Walker A/P-loop; other site
1423144012660	ATP binding site [chemical binding]; other site
1423144012661	CHC2 zinc finger; Region: zf-CHC2; cl17510
1423144012662	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
1423144012663	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
1423144012664	DNA methylase; Region: N6_N4_Mtase; cl17433
1423144012665	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1423144012666	non-specific DNA binding site [nucleotide binding]; other site
1423144012667	salt bridge; other site
1423144012668	sequence-specific DNA binding site [nucleotide binding]; other site
1423144012669	transcriptional regulator TraR; Provisional; Region: PRK13870
1423144012670	Autoinducer binding domain; Region: Autoind_bind; pfam03472
1423144012671	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
1423144012672	DNA binding residues [nucleotide binding]
1423144012673	dimerization interface [polypeptide binding]; other site
1423144012674	Autoinducer synthetase; Region: Autoind_synth; cl17404
1423144012675	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
1423144012676	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1423144012677	non-specific DNA binding site [nucleotide binding]; other site
1423144012678	salt bridge; other site
1423144012679	sequence-specific DNA binding site [nucleotide binding]; other site
1423144012680	conserved hypothetical protein; Region: Lon_rel_chp; TIGR02653
1423144012681	plasmid partitioning protein RepA; Region: partition_RepA; TIGR03453
1423144012682	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
1423144012683	DNA binding residues [nucleotide binding]
1423144012684	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
1423144012685	P-loop; other site
1423144012686	Magnesium ion binding site [ion binding]; other site
1423144012687	plasmid partitioning protein RepB; Region: partition_RepB; TIGR03454
1423144012688	ParB-like nuclease domain; Region: ParB; smart00470
1423144012689	Replication protein C N-terminal domain; Region: RP-C; pfam03428
1423144012690	replication initiation protein RepC; Provisional; Region: PRK13824
1423144012691	Replication protein C C-terminal region; Region: RP-C_C; pfam11800
1423144012692	Fic family protein [Function unknown]; Region: COG3177
1423144012693	Fic/DOC family; Region: Fic; pfam02661
1423144012694	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
1423144012695	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
1423144012696	INT_SG5, DNA breaking-rejoining enzymes, integrase/recombinases subgroup 5, N- and C-terminal domains. The CD contains mainly predicted bacterial integrase/recombinases; Region: INT_SG5; cd01190
1423144012697	Int/Topo IB signature motif; other site
1423144012698	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
1423144012699	active site
1423144012700	DNA binding site [nucleotide binding]
1423144012701	Int/Topo IB signature motif; other site
1423144012702	site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236
1423144012703	Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235
1423144012704	pAE1 and related integrases, DNA breaking-rejoining enzymes, integrase/recombinases, C-terminal domain. This CD includes various bacterial integrases, including the predicted integrase of the deletion-prone region of plasmid pAE1 of Alcaligenes eutrophus...; Region: INT_pAE1; cd01188
1423144012705	Int/Topo IB signature motif; other site
1423144012706	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
1423144012707	Protein of unknown function (DUF3768); Region: DUF3768; pfam12599
1423144012708	ParB-like nuclease domain; Region: ParB; smart00470
1423144012709	putative regulator PrlF; Provisional; Region: PRK09974
1423144012710	Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002
1423144012711	Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663
1423144012712	Methyltransferase domain; Region: Methyltransf_26; pfam13659
1423144012713	P-loop containing NTP hydrolase pore-1; Region: AAA_34; pfam13872
1423144012714	Helicase_C-like; Region: Helicase_C_4; pfam13871
1423144012715	Protein of unknown function (DUF736); Region: DUF736; pfam05284
1423144012716	Protein of unknown function (DUF736); Region: DUF736; pfam05284
1423144012717	P-loop containing region of AAA domain; Region: AAA_29; cl17516
1423144012718	AAA domain; Region: AAA_23; pfam13476
1423144012719	AAA domain; Region: AAA_27; pfam13514
1423144012720	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
1423144012721	active site
1423144012722	metal binding site [ion binding]; metal-binding site
1423144012723	DNA binding site [nucleotide binding]
1423144012724	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
1423144012725	Part of AAA domain; Region: AAA_19; pfam13245
1423144012726	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
1423144012727	AAA ATPase domain; Region: AAA_15; pfam13175
1423144012728	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
1423144012729	Walker A/P-loop; other site
1423144012730	ATP binding site [chemical binding]; other site
1423144012731	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
1423144012732	putative active site [active]
1423144012733	putative metal-binding site [ion binding]; other site
1423144012734	Protein of unknown function (DUF2493); Region: DUF2493; pfam10686
1423144012735	Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393
1423144012736	type IV secretion system T-DNA border endonuclease VirD2; Provisional; Region: PRK13863
1423144012737	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
1423144012738	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
1423144012739	Walker A motif; other site
1423144012740	ATP binding site [chemical binding]; other site
1423144012741	Walker B motif; other site
1423144012742	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
1423144012743	DNA binding residues [nucleotide binding]
1423144012744	Hg(II)-responsive transcriptional regulator; Region: MerR; TIGR02051
1423144012745	dimer interface [polypeptide binding]; other site
1423144012746	putative metal binding site [ion binding]; other site
1423144012747	MerT mercuric transport protein; Region: MerT; cl03578
1423144012748	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cl00207
1423144012749	metal-binding site [ion binding]
1423144012750	Membrane transport protein MerF; Region: Transport_MerF; pfam11431
1423144012751	mercuric reductase; Region: MerA; TIGR02053
1423144012752	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1423144012753	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1423144012754	Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249
1423144012755	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
1423144012756	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
1423144012757	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
1423144012758	TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610
1423144012759	Domain of unknown function (DUF4177); Region: DUF4177; pfam13783
1423144012760	P-type DNA transfer ATPase VirB11; Region: VirB11; TIGR02788
1423144012761	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
1423144012762	Walker A motif; other site
1423144012763	hexamer interface [polypeptide binding]; other site
1423144012764	ATP binding site [chemical binding]; other site
1423144012765	Walker B motif; other site
1423144012766	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
1423144012767	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cl11423
1423144012768	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
1423144012769	VirB7 interaction site; other site
1423144012770	VirB8 protein; Region: VirB8; pfam04335
1423144012771	P-type DNA transfer protein VirB5; Region: VirB5; TIGR02791
1423144012772	Type IV secretion system proteins; Region: T4SS; pfam07996
1423144012773	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1423144012774	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1423144012775	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1423144012776	catalytic residue [active]
1423144012777	type IV secretion/conjugal transfer ATPase, VirB4 family; Region: VirB4_CagE; TIGR00929
1423144012778	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
1423144012779	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
1423144012780	TrbC/VIRB2 family; Region: TrbC; pfam04956
1423144012781	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
1423144012782	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
1423144012783	N-acetyl-D-glucosamine binding site [chemical binding]; other site
1423144012784	catalytic residue [active]
1423144012785	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
1423144012786	non-specific DNA binding site [nucleotide binding]; other site
1423144012787	salt bridge; other site
1423144012788	sequence-specific DNA binding site [nucleotide binding]; other site
1423144012789	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1423144012790	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1423144012791	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1423144012792	Phospholipid methyltransferase; Region: PEMT; pfam04191
1423144012793	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1423144012794	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
1423144012795	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
1423144012796	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
1423144012797	Uncharacterized conserved protein [Function unknown]; Region: COG1742
1423144012798	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
1423144012799	Helix-Turn-Helix DNA binding domain of the CadR- and PbrR-like transcription regulators; Region: HTH_CadR-PbrR-like; cd04785
1423144012800	DNA binding residues [nucleotide binding]
1423144012801	dimer interface [polypeptide binding]; other site
1423144012802	putative metal binding site [ion binding]; other site
1423144012803	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
1423144012804	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
1423144012805	Cu(I) binding site [ion binding]; other site
1423144012806	Disulfide bond formation protein DsbB; Region: DsbB; cl00649
1423144012807	Thioredoxin; Region: Thioredoxin_4; pfam13462
1423144012808	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1423144012809	Protein of unknown function (DUF461); Region: DUF461; pfam04314
1423144012810	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
1423144012811	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
1423144012812	Cu(I) binding site [ion binding]; other site
1423144012813	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
1423144012814	Peptidase family M23; Region: Peptidase_M23; pfam01551
1423144012815	Protein of unknown function, DUF; Region: DUF411; cl01142
1423144012816	Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428
1423144012817	Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252
1423144012818	lipoprotein signal peptidase; Provisional; Region: PRK14787
1423144012819	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
1423144012820	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
1423144012821	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
1423144012822	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
1423144012823	Uncharacterized conserved protein [Function unknown]; Region: COG5569
1423144012824	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
1423144012825	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1423144012826	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1423144012827	Outer membrane efflux protein; Region: OEP; pfam02321
1423144012828	Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531
1423144012829	Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043
1423144012830	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
1423144012831	copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511
1423144012832	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1423144012833	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1423144012834	motif II; other site
1423144012835	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
1423144012836	Domain of unknown function DUF302; Region: DUF302; pfam03625
1423144012837	EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302
1423144012838	EF-hand domain pair; Region: EF_hand_5; pfam13499
1423144012839	Ca2+ binding site [ion binding]; other site
1423144012840	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1423144012841	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1423144012842	Disulfide bond formation protein DsbB; Region: DsbB; pfam02600
1423144012843	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
1423144012844	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1423144012845	Multicopper oxidase; Region: Cu-oxidase; pfam00394
1423144012846	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1423144012847	Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376
1423144012848	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1423144012849	Domain of unknown function (DUF305); Region: DUF305; cl17794
1423144012850	Glutaredoxin and related proteins [Posttranslational modification, protein turnover, chaperones]; Region: GrxC; COG0695
1423144012851	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
1423144012852	Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108
1423144012853	DNA binding residues [nucleotide binding]
1423144012854	dimer interface [polypeptide binding]; other site
1423144012855	copper binding site [ion binding]; other site
1423144012856	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1423144012857	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1423144012858	metal-binding site [ion binding]
1423144012859	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
1423144012860	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1423144012861	metal-binding site [ion binding]
1423144012862	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
1423144012863	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
1423144012864	motif II; other site
1423144012865	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
1423144012866	metal-binding site [ion binding]
1423144012867	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
1423144012868	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
1423144012869	catalytic residues [active]
1423144012870	Cytochrome c; Region: Cytochrom_C; pfam00034
1423144012871	Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132
1423144012872	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
1423144012873	Multicopper oxidase; Region: Cu-oxidase; pfam00394
1423144012874	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
1423144012875	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
1423144012876	Cytochrome C' Region: Cytochrom_C_2; pfam01322
1423144012877	Cytochrome c; Region: Cytochrom_C; pfam00034
1423144012878	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
1423144012879	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
1423144012880	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
1423144012881	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
1423144012882	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
1423144012883	DsbD alpha interface [polypeptide binding]; other site
1423144012884	catalytic residues [active]
1423144012885	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
1423144012886	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
1423144012887	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
1423144012888	binding surface
1423144012889	TPR motif; other site
1423144012890	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
1423144012891	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
1423144012892	periplasmic protein thiol:disulfide oxidoreductases, DsbE subfamily; Region: dsbE; TIGR00385
1423144012893	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
1423144012894	catalytic residues [active]
1423144012895	central insert; other site
1423144012896	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
1423144012897	Predicted membrane protein [Function unknown]; Region: COG3462
1423144012898	Short C-terminal domain; Region: SHOCT; pfam09851
1423144012899	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
1423144012900	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
1423144012901	dimerization interface [polypeptide binding]; other site
1423144012902	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
1423144012903	dimer interface [polypeptide binding]; other site
1423144012904	phosphorylation site [posttranslational modification]
1423144012905	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
1423144012906	ATP binding site [chemical binding]; other site
1423144012907	Mg2+ binding site [ion binding]; other site
1423144012908	G-X-G motif; other site
1423144012909	osmolarity response regulator; Provisional; Region: ompR; PRK09468
1423144012910	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
1423144012911	active site
1423144012912	phosphorylation site [posttranslational modification]
1423144012913	intermolecular recognition site; other site
1423144012914	dimerization interface [polypeptide binding]; other site
1423144012915	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
1423144012916	DNA binding site [nucleotide binding]
1423144012917	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125
1423144012918	active site residue [active]
1423144012919	Uncharacterized conserved protein [Function unknown]; Region: COG0398
1423144012920	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
1423144012921	TniQ; Region: TniQ; pfam06527
1423144012922	Bacterial TniB protein; Region: TniB; pfam05621
1423144012923	AAA domain; Region: AAA_22; pfam13401
1423144012924	Helix-turn-helix domain; Region: HTH_28; pfam13518
1423144012925	Winged helix-turn helix; Region: HTH_29; pfam13551
1423144012926	Homeodomain-like domain; Region: HTH_32; pfam13565
1423144012927	Integrase core domain; Region: rve; pfam00665
1423144012928	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
1423144012929	Tannase and feruloyl esterase; Region: Tannase; pfam07519
1423144012930	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
1423144012931	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
1423144012932	TniQ; Region: TniQ; pfam06527
1423144012933	Bacterial TniB protein; Region: TniB; pfam05621
1423144012934	AAA domain; Region: AAA_22; pfam13401
1423144012935	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
1423144012936	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
1423144012937	PIN domain; Region: PIN_3; pfam13470
1423144012938	Helix-turn-helix domain; Region: HTH_17; cl17695
1423144012939	HTH DNA binding domain; Region: HTH_13; pfam11972
1423144012940	Winged helix-turn helix; Region: HTH_29; pfam13551
1423144012941	Integrase core domain; Region: rve; pfam00665
1423144012942	Mu transposase, C-terminal; Region: Mu-transpos_C; pfam09299
1423144012943	Bacterial TniB protein; Region: TniB; pfam05621
1423144012944	AAA domain; Region: AAA_22; pfam13401
1423144012945	TniQ; Region: TniQ; pfam06527
1423144012946	Chromosome segregation and condensation protein B [DNA replication, recombination and repair]; Region: scpB; COG1386
1423144012947	Protein of unknown function (DUF1403); Region: DUF1403; pfam07183
1423144012948	Cre recombinase, C-terminal catalytic domain. Cre-like recombinases belong to the superfamily of DNA breaking-rejoining enzymes, which share the same fold in their catalytic domain and the overall reaction mechanism. The bacteriophage P1 Cre...; Region: INT_Cre; cd00799
1423144012949	DNA binding site [nucleotide binding]
1423144012950	dimer interface [polypeptide binding]; other site
1423144012951	Int/Topo IB signature motif; other site
1423144012952	active site
1423144012953	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
1423144012954	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
1423144012955	catalytic residues [active]
1423144012956	catalytic nucleophile [active]
1423144012957	Presynaptic Site I dimer interface [polypeptide binding]; other site
1423144012958	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
1423144012959	Synaptic Flat tetramer interface [polypeptide binding]; other site
1423144012960	Synaptic Site I dimer interface [polypeptide binding]; other site
1423144012961	DNA binding site [nucleotide binding]