-- dump date   	20140619_233755
-- class       	Genbank::misc_feature
-- table       	misc_feature_note
-- id	note
298386000001	TraY domain; Region: TraY; pfam05509
298386000002	type IV conjugative transfer system pilin TraA; Region: TraA_TIGR; TIGR02758
298386000003	TraE protein; Region: TraE; cl05060
298386000004	TraK protein; Region: TraK; pfam06586
298386000005	type-F conjugative transfer system secretin TraK; Region: TraK_Ftype; TIGR02756
298386000006	conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729
298386000007	Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743
298386000008	type IV conjugative transfer system lipoprotein TraV; Region: TraV; TIGR02747
298386000009	Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676
298386000010	F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130
298386000011	type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746
298386000012	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983
298386000013	type-F conjugative transfer system protein TraW; Region: TraW; TIGR02743
298386000014	TraU protein; Region: TraU; cl06067
298386000015	type-F conjugative transfer system pilin assembly protein TrbC; Region: TrbC_Ftype; TIGR02742
298386000016	type-F conjugative transfer system mating-pair stabilization protein TraN; Region: TraN_Ftype; TIGR02750
298386000017	type-F conjugative transfer system pilin assembly protein TraF; Region: TraF; TIGR02739
298386000018	F plasmid transfer operon protein; Region: TraF; pfam13728
298386000019	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
298386000020	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
298386000021	catalytic residues [active]
298386000022	TraG-like protein, N-terminal region; Region: TraG_N; pfam07916
298386000023	type IV conjugative transfer system coupling protein TraD; Region: TraD_Ftype; TIGR02759
298386000024	F sex factor protein N terminal; Region: TraD_N; pfam12615
298386000025	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
298386000026	Walker A motif; other site
298386000027	ATP binding site [chemical binding]; other site
298386000028	Walker B motif; other site
298386000029	conjugative transfer relaxase protein TraI; Region: TraI_TIGR; TIGR02760
298386000030	conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686
298386000031	AAA domain; Region: AAA_30; pfam13604
298386000032	Toprim domain; Region: Toprim_3; pfam13362
298386000033	type III secretion system protein; Validated; Region: PRK05910
298386000034	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
298386000035	Protein of unknown function, DUF462; Region: DUF462; cl01190
298386000036	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
298386000037	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
298386000038	P-loop; other site
298386000039	Magnesium ion binding site [ion binding]; other site
298386000040	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
298386000041	Magnesium ion binding site [ion binding]; other site
298386000042	ParB-like nuclease domain; Region: ParB; smart00470
298386000043	Homeodomain-like domain; Region: HTH_23; pfam13384
298386000044	ParB family; Region: ParB; pfam08775
298386000045	Endonuclease I; Region: Endonuclease_1; pfam04231
298386000046	Protein of unknown function (DUF2913); Region: DUF2913; pfam11140
298386000047	CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648
298386000048	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719
298386000049	Cascade antiviral complex protein; Validated; Region: PRK09693
298386000050	CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704
298386000051	CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09756
298386000052	CT1975-like protein; Region: Cas_CT1975; pfam09344
298386000053	CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09670
298386000054	CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09727
298386000055	helicase Cas3; Provisional; Region: PRK09694
298386000056	CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641
298386000057	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
298386000058	LabA_like proteins; Region: LabA_like; cd06167
298386000059	putative metal binding site [ion binding]; other site
298386000060	AAA ATPase domain; Region: AAA_15; pfam13175
298386000061	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298386000062	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
298386000063	Walker A/P-loop; other site
298386000064	ATP binding site [chemical binding]; other site
298386000065	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
298386000066	putative active site [active]
298386000067	putative metal-binding site [ion binding]; other site
298386000068	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
298386000069	Family description; Region: UvrD_C_2; pfam13538
298386000070	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298386000071	S-adenosylmethionine binding site [chemical binding]; other site
298386000072	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
298386000073	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
298386000074	Serine recombinase (SR) family, Partitioning (par)-Resolvase subfamily, catalytic domain; Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining mechanism which involves a transient...; Region: SR_Res_par; cd03767
298386000075	catalytic residues [active]
298386000076	catalytic nucleophile [active]
298386000077	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
298386000078	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
298386000079	Uncharacterized subfamily of N-terminal LabA-like domains; Region: LabA_like_N_1; cd11297
298386000080	putative metal binding site [ion binding]; other site
298386000081	Uncharacterized conserved protein [Function unknown]; Region: COG1432
298386000082	C-terminal domain of LabA_like proteins; Region: LabA_like_C; cl14879
298386000083	DDE domain; Region: DDE_Tnp_IS240; pfam13610
298386000084	DDE domain; Region: DDE_Tnp_IS240; pfam13610
298386000085	Integrase core domain; Region: rve; pfam00665
298386000086	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
298386000087	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
298386000088	Plasmid replication region DNA-binding N-term; Region: KfrA_N; pfam11740
298386000089	FMN-binding protein MioC; Provisional; Region: PRK09004
298386000090	tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291
298386000091	GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396
298386000092	trmE is a tRNA modification GTPase; Region: trmE; cd04164
298386000093	G1 box; other site
298386000094	GTP/Mg2+ binding site [chemical binding]; other site
298386000095	Switch I region; other site
298386000096	G2 box; other site
298386000097	Switch II region; other site
298386000098	G3 box; other site
298386000099	G4 box; other site
298386000100	G5 box; other site
298386000101	Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631
298386000102	membrane protein insertase; Provisional; Region: PRK01318
298386000103	membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592
298386000104	ribonuclease P; Reviewed; Region: rnpA; PRK01732
298386000105	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
298386000106	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298386000107	Walker A/P-loop; other site
298386000108	ATP binding site [chemical binding]; other site
298386000109	Q-loop/lid; other site
298386000110	ABC transporter signature motif; other site
298386000111	Walker B; other site
298386000112	D-loop; other site
298386000113	H-loop/switch region; other site
298386000114	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
298386000115	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386000116	dimer interface [polypeptide binding]; other site
298386000117	conserved gate region; other site
298386000118	putative PBP binding loops; other site
298386000119	ABC-ATPase subunit interface; other site
298386000120	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
298386000121	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
298386000122	substrate binding pocket [chemical binding]; other site
298386000123	membrane-bound complex binding site; other site
298386000124	hinge residues; other site
298386000125	DnaA N-terminal domain; Region: DnaA_N; pfam11638
298386000126	chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362
298386000127	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298386000128	Walker A motif; other site
298386000129	ATP binding site [chemical binding]; other site
298386000130	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
298386000131	Walker B motif; other site
298386000132	arginine finger; other site
298386000133	C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571
298386000134	DnaA box-binding interface [nucleotide binding]; other site
298386000135	DNA polymerase III subunit beta; Validated; Region: PRK05643
298386000136	Beta clamp domain.  The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria.  The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140
298386000137	putative DNA binding surface [nucleotide binding]; other site
298386000138	dimer interface [polypeptide binding]; other site
298386000139	beta-clamp/clamp loader binding surface; other site
298386000140	beta-clamp/translesion DNA polymerase binding surface; other site
298386000141	recombination protein F; Reviewed; Region: recF; PRK00064
298386000142	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298386000143	Walker A/P-loop; other site
298386000144	ATP binding site [chemical binding]; other site
298386000145	Q-loop/lid; other site
298386000146	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298386000147	ABC transporter signature motif; other site
298386000148	Walker B; other site
298386000149	D-loop; other site
298386000150	H-loop/switch region; other site
298386000151	DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939
298386000152	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386000153	Mg2+ binding site [ion binding]; other site
298386000154	G-X-G motif; other site
298386000155	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
298386000156	anchoring element; other site
298386000157	dimer interface [polypeptide binding]; other site
298386000158	ATP binding site [chemical binding]; other site
298386000159	TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366
298386000160	active site
298386000161	putative metal-binding site [ion binding]; other site
298386000162	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
298386000163	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
298386000164	FHIPEP family; Region: FHIPEP; pfam00771
298386000165	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
298386000166	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822
298386000167	Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684
298386000168	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
298386000169	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
298386000170	flagellar motor switch protein FliN; Region: fliN; TIGR02480
298386000171	flagellar motor switch protein FliM; Region: fliM_switch; TIGR01397
298386000172	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
298386000173	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
298386000174	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
298386000175	ligand binding site [chemical binding]; other site
298386000176	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
298386000177	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386000178	active site
298386000179	phosphorylation site [posttranslational modification]
298386000180	intermolecular recognition site; other site
298386000181	dimerization interface [polypeptide binding]; other site
298386000182	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298386000183	Walker A motif; other site
298386000184	ATP binding site [chemical binding]; other site
298386000185	Walker B motif; other site
298386000186	arginine finger; other site
298386000187	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
298386000188	Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049
298386000189	flagellar MS-ring protein; Reviewed; Region: fliF; PRK07193
298386000190	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
298386000191	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
298386000192	flagellar motor switch protein G; Reviewed; Region: fliG; PRK07194
298386000193	MgtE intracellular N domain; Region: MgtE_N; smart00924
298386000194	FliG C-terminal domain; Region: FliG_C; pfam01706
298386000195	flagellar assembly protein H; Provisional; Region: fliH; PRK13386
298386000196	Flagellar assembly protein FliH; Region: FliH; pfam02108
298386000197	flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496
298386000198	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
298386000199	Walker A motif/ATP binding site; other site
298386000200	Walker B motif; other site
298386000201	FlgN protein; Region: FlgN; pfam05130
298386000202	flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824
298386000203	SAF-like; Region: SAF_2; pfam13144
298386000204	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
298386000205	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
298386000206	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
298386000207	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK12685
298386000208	flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK06802
298386000209	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
298386000210	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
298386000211	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
298386000212	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
298386000213	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
298386000214	flagellar hook protein FlgE; Validated; Region: flgE; PRK06803
298386000215	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
298386000216	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
298386000217	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
298386000218	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
298386000219	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
298386000220	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
298386000221	flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490
298386000222	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
298386000223	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
298386000224	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
298386000225	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
298386000226	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
298386000227	Rod binding protein; Region: Rod-binding; cl01626
298386000228	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07191
298386000229	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
298386000230	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK07192
298386000231	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
298386000232	flagellin; Reviewed; Region: PRK08869
298386000233	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
298386000234	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
298386000235	Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345
298386000236	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
298386000237	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
298386000238	Flagellar protein FliS; Region: FliS; cl00654
298386000239	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
298386000240	Flagellar basal body-associated protein FliL; Region: FliL; pfam03748
298386000241	RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479
298386000242	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298386000243	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
298386000244	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
298386000245	DNA binding residues [nucleotide binding]
298386000246	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
298386000247	flagellar motor stator protein MotA; Region: MotA1; TIGR03818
298386000248	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
298386000249	hypothetical protein; Validated; Region: PRK06778
298386000250	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
298386000251	ligand binding site [chemical binding]; other site
298386000252	Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227
298386000253	Mg binding site [ion binding]; other site
298386000254	nucleotide binding site [chemical binding]; other site
298386000255	putative protofilament interface [polypeptide binding]; other site
298386000256	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
298386000257	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
298386000258	putative dimer interface [polypeptide binding]; other site
298386000259	valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440
298386000260	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
298386000261	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298386000262	homodimer interface [polypeptide binding]; other site
298386000263	catalytic residue [active]
298386000264	glycyl-tRNA synthetase subunit beta; Validated; Region: glyS; PRK01233
298386000265	Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733
298386000266	dimer interface [polypeptide binding]; other site
298386000267	motif 1; other site
298386000268	active site
298386000269	motif 2; other site
298386000270	motif 3; other site
298386000271	putative outer membrane lipoprotein; Provisional; Region: PRK10510
298386000272	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
298386000273	ligand binding site [chemical binding]; other site
298386000274	Predicted membrane protein [Function unknown]; Region: COG2119
298386000275	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
298386000276	Uncharacterized protein family UPF0016; Region: UPF0016; pfam01169
298386000277	seryl-tRNA synthetase; Region: PLN02678
298386000278	SirA (also known as UvrY,  and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA.  A...; Region: SirA; cd03423
298386000279	CPxP  motif; other site
298386000280	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386000281	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386000282	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
298386000283	substrate binding pocket [chemical binding]; other site
298386000284	dimerization interface [polypeptide binding]; other site
298386000285	Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288
298386000286	putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823
298386000287	NADP binding site [chemical binding]; other site
298386000288	dimer interface [polypeptide binding]; other site
298386000289	3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947
298386000290	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
298386000291	dimer interface [polypeptide binding]; other site
298386000292	active site
298386000293	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730
298386000294	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298386000295	substrate binding site [chemical binding]; other site
298386000296	oxyanion hole (OAH) forming residues; other site
298386000297	trimer interface [polypeptide binding]; other site
298386000298	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
298386000299	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
298386000300	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
298386000301	hypothetical protein; Provisional; Region: PRK11568
298386000302	Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205
298386000303	Domain of unknown function (DUF1949); Region: DUF1949; pfam09186
298386000304	Cation transport protein; Region: TrkH; cl17365
298386000305	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
298386000306	protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104
298386000307	DDE superfamily endonuclease; Region: DDE_3; pfam13358
298386000308	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
298386000309	Homeodomain-like domain; Region: HTH_23; pfam13384
298386000310	Winged helix-turn helix; Region: HTH_29; pfam13551
298386000311	Winged helix-turn helix; Region: HTH_33; pfam13592
298386000312	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
298386000313	Transposase; Region: DEDD_Tnp_IS110; pfam01548
298386000314	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
298386000315	DDE superfamily endonuclease; Region: DDE_3; pfam13358
298386000316	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
298386000317	Homeodomain-like domain; Region: HTH_23; pfam13384
298386000318	Winged helix-turn helix; Region: HTH_29; pfam13551
298386000319	Winged helix-turn helix; Region: HTH_33; pfam13592
298386000320	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
298386000321	Transposase; Region: DEDD_Tnp_IS110; pfam01548
298386000322	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
298386000323	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386000324	DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716
298386000325	The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430
298386000326	putative dimerization interface [polypeptide binding]; other site
298386000327	ketol-acid reductoisomerase; Validated; Region: PRK05225
298386000328	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991
298386000329	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
298386000330	Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450
298386000331	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960
298386000332	multidrug efflux protein; Reviewed; Region: PRK09579
298386000333	HlyD family secretion protein; Region: HlyD_3; pfam13437
298386000334	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
298386000335	HlyD family secretion protein; Region: HlyD_3; pfam13437
298386000336	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298386000337	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298386000338	ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919
298386000339	Part of AAA domain; Region: AAA_19; pfam13245
298386000340	Family description; Region: UvrD_C_2; pfam13538
298386000341	Cytochrome c5 [Energy production and conversion]; Region: CycB; COG3245
298386000342	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
298386000343	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
298386000344	Walker A/P-loop; other site
298386000345	ATP binding site [chemical binding]; other site
298386000346	Q-loop/lid; other site
298386000347	ABC transporter signature motif; other site
298386000348	Walker B; other site
298386000349	D-loop; other site
298386000350	H-loop/switch region; other site
298386000351	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
298386000352	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
298386000353	Walker A/P-loop; other site
298386000354	ATP binding site [chemical binding]; other site
298386000355	Q-loop/lid; other site
298386000356	ABC transporter signature motif; other site
298386000357	Walker B; other site
298386000358	D-loop; other site
298386000359	H-loop/switch region; other site
298386000360	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
298386000361	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_2; cd08498
298386000362	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
298386000363	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386000364	dimer interface [polypeptide binding]; other site
298386000365	conserved gate region; other site
298386000366	putative PBP binding loops; other site
298386000367	ABC-ATPase subunit interface; other site
298386000368	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
298386000369	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
298386000370	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386000371	dimer interface [polypeptide binding]; other site
298386000372	conserved gate region; other site
298386000373	putative PBP binding loops; other site
298386000374	ABC-ATPase subunit interface; other site
298386000375	camphor resistance protein CrcB; Provisional; Region: PRK14200
298386000376	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386000377	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
298386000378	Ligand Binding Site [chemical binding]; other site
298386000379	thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284
298386000380	ThiC-associated domain; Region: ThiC-associated; pfam13667
298386000381	Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422
298386000382	thiamine-phosphate pyrophosphorylase; Reviewed; Region: thiE; PRK12290
298386000383	Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564
298386000384	thiamine phosphate binding site [chemical binding]; other site
298386000385	active site
298386000386	pyrophosphate binding site [ion binding]; other site
298386000387	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
298386000388	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
298386000389	ATP binding site [chemical binding]; other site
298386000390	substrate interface [chemical binding]; other site
298386000391	Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728
298386000392	ThiS interaction site; other site
298386000393	putative active site [active]
298386000394	tetramer interface [polypeptide binding]; other site
298386000395	thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240
298386000396	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
298386000397	FeS/SAM binding site; other site
298386000398	Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968
298386000399	Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321
298386000400	Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006
298386000401	X-Prolyl Aminopeptidase 2. E.C. 3.4.11.9. Also known as X-Pro aminopeptidase, proline aminopeptidase, aminopeptidase P, and aminoacylproline aminopeptidase. Catalyses release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP; cd01085
298386000402	active site
298386000403	DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216
298386000404	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386000405	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
298386000406	substrate binding pocket [chemical binding]; other site
298386000407	dimerization interface [polypeptide binding]; other site
298386000408	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
298386000409	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298386000410	putative substrate translocation pore; other site
298386000411	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
298386000412	EamA-like transporter family; Region: EamA; pfam00892
298386000413	DNA recombination protein RmuC; Provisional; Region: PRK10361
298386000414	RmuC family; Region: RmuC; pfam02646
298386000415	ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209
298386000416	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298386000417	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165
298386000418	SCP-2 sterol transfer family; Region: SCP2; pfam02036
298386000419	putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750
298386000420	2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982
298386000421	mttA/Hcf106 family; Region: MttA_Hcf106; cl00788
298386000422	sec-independent translocase; Provisional; Region: PRK01770
298386000423	Sec-independent protein translocase protein (TatC); Region: TatC; cl00521
298386000424	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
298386000425	active site
298386000426	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS_aspartate_rich; cd04823
298386000427	dimer interface [polypeptide binding]; other site
298386000428	allosteric magnesium binding site [ion binding]; other site
298386000429	active site
298386000430	aspartate-rich active site metal binding site; other site
298386000431	Schiff base residues; other site
298386000432	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
298386000433	EamA-like transporter family; Region: EamA; cl17759
298386000434	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
298386000435	Ligand Binding Site [chemical binding]; other site
298386000436	nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055
298386000437	Ferritin-like domain; Region: Ferritin; pfam00210
298386000438	ferroxidase diiron center [ion binding]; other site
298386000439	Universal stress protein B (UspB); Region: UspB; pfam10625
298386000440	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
298386000441	Mechanosensitive ion channel; Region: MS_channel; pfam00924
298386000442	HI0933-like protein; Region: HI0933_like; pfam03486
298386000443	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
298386000444	Domain of unknown function (DUF3332); Region: DUF3332; pfam11810
298386000445	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298386000446	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298386000447	aldehyde dehydrogenase family protein; Provisional; Region: PTZ00381
298386000448	Coniferyl aldehyde dehydrogenase-like; Region: ALDH_CALDH_CalB; cd07133
298386000449	NAD(P) binding site [chemical binding]; other site
298386000450	catalytic residues [active]
298386000451	DTW domain; Region: DTW; cl01221
298386000452	Predicted membrane protein [Function unknown]; Region: COG3650
298386000453	EVE domain; Region: EVE; cl00728
298386000454	putative hydrolase; Provisional; Region: PRK10976
298386000455	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
298386000456	active site
298386000457	motif I; other site
298386000458	motif II; other site
298386000459	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
298386000460	lysophospholipase L2; Provisional; Region: PRK10749
298386000461	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
298386000462	methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657
298386000463	homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520
298386000464	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
298386000465	EAL domain; Region: EAL; pfam00563
298386000466	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
298386000467	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
298386000468	active site
298386000469	nucleophile elbow; other site
298386000470	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386000471	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386000472	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
298386000473	dimerization interface [polypeptide binding]; other site
298386000474	AbgT putative transporter family; Region: ABG_transport; pfam03806
298386000475	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
298386000476	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
298386000477	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298386000478	NAD(P) binding site [chemical binding]; other site
298386000479	active site
298386000480	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
298386000481	Acyltransferase family; Region: Acyl_transf_3; pfam01757
298386000482	Protein of unknown function (DUF2500); Region: DUF2500; pfam10694
298386000483	YhhN-like protein; Region: YhhN; pfam07947
298386000484	Domain of unknown function (DUF2007); Region: DUF2007; pfam09413
298386000485	Protein of unknown function (DUF2492); Region: DUF2492; pfam10678
298386000486	putative antibiotic transporter; Provisional; Region: PRK10739
298386000487	Predicted membrane protein [Function unknown]; Region: COG3776
298386000488	N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742
298386000489	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298386000490	S-adenosylmethionine binding site [chemical binding]; other site
298386000491	signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416
298386000492	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
298386000493	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
298386000494	P loop; other site
298386000495	GTP binding site [chemical binding]; other site
298386000496	Cell division protein [Cell division and chromosome partitioning]; Region: FtsX; COG2177
298386000497	cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026
298386000498	RNA polymerase factor sigma-32; Reviewed; Region: PRK06596
298386000499	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
298386000500	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298386000501	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
298386000502	DNA binding residues [nucleotide binding]
298386000503	GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444
298386000504	active site residue [active]
298386000505	Protein of unknown function (DUF3582); Region: DUF3582; pfam12122
298386000506	rhomboid family protease GlpG; Region: rhombo_GlpG; TIGR04239
298386000507	Rhomboid family; Region: Rhomboid; pfam01694
298386000508	sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273
298386000509	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298386000510	putative substrate translocation pore; other site
298386000511	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298386000512	DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906
298386000513	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
298386000514	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
298386000515	glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266
298386000516	flagellar basal body-associated protein FliL-like protein; Validated; Region: PRK05697
298386000517	Chorismate lyase; Region: Chor_lyase; cl01230
298386000518	4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848
298386000519	UbiA prenyltransferase family; Region: UbiA; pfam01040
298386000520	glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703
298386000521	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993
298386000522	putative acyl-acceptor binding pocket; other site
298386000523	LexA repressor; Validated; Region: PRK00215
298386000524	LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726
298386000525	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
298386000526	Catalytic site [active]
298386000527	O-Methyltransferase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3315
298386000528	Leucine carboxyl methyltransferase; Region: LCM; pfam04072
298386000529	Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622
298386000530	Cytochrome C oxidase subunit II, transmembrane domain; Region: COX2_TM; pfam02790
298386000531	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
298386000532	Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010
298386000533	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
298386000534	Cytochrome C oxidase subunit I.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_I; cd01663
298386000535	Subunit I/III interface [polypeptide binding]; other site
298386000536	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
298386000537	D-pathway; other site
298386000538	Subunit I/VIIc interface [polypeptide binding]; other site
298386000539	Subunit I/IV interface [polypeptide binding]; other site
298386000540	Subunit I/II interface [polypeptide binding]; other site
298386000541	Low-spin heme (heme a) binding site [chemical binding]; other site
298386000542	Subunit I/VIIa interface [polypeptide binding]; other site
298386000543	Subunit I/VIa interface [polypeptide binding]; other site
298386000544	Dimer interface; other site
298386000545	Putative water exit pathway; other site
298386000546	Binuclear center (heme a3/CuB) [ion binding]; other site
298386000547	K-pathway; other site
298386000548	Subunit I/Vb interface [polypeptide binding]; other site
298386000549	Putative proton exit pathway; other site
298386000550	Subunit I/VIb interface; other site
298386000551	Subunit I/VIc interface [polypeptide binding]; other site
298386000552	Electron transfer pathway; other site
298386000553	Subunit I/VIIIb interface [polypeptide binding]; other site
298386000554	Subunit I/VIIb interface [polypeptide binding]; other site
298386000555	cytochrome C oxidase assembly protein; Provisional; Region: PRK05089
298386000556	Cytochrome c oxidase subunit III.  Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of...; Region: Cyt_c_Oxidase_III; cd01665
298386000557	Subunit III/VIIa interface [polypeptide binding]; other site
298386000558	Phospholipid binding site [chemical binding]; other site
298386000559	Subunit I/III interface [polypeptide binding]; other site
298386000560	Subunit III/VIa interface; other site
298386000561	Subunit III/Vb interface [polypeptide binding]; other site
298386000562	SURF1 superfamily. Surf1/Shy1 has been implicated in the posttranslational steps of the biogenesis of the mitochondrially-encoded Cox1 subunit of cytochrome c oxidase (complex IV). Cytochrome c oxidase (complex IV), the terminal electron-transferring...; Region: SURF1; cd06662
298386000563	Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cl00338
298386000564	Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628
298386000565	Uncharacterized protein required for cytochrome oxidase assembly [Posttranslational modification, protein turnover, chaperones]; Region: CtaA; COG1612
298386000566	protoheme IX farnesyltransferase; Provisional; Region: PRK04375
298386000567	UbiA prenyltransferase family; Region: UbiA; pfam01040
298386000568	DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136
298386000569	DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367
298386000570	3D domain; Region: 3D; cl01439
298386000571	Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190
298386000572	Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316
298386000573	Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694
298386000574	Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040
298386000575	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
298386000576	active site
298386000577	pimelyl-[acyl-carrier protein] methyl ester esterase; Region: bioH; TIGR01738
298386000578	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
298386000579	Transcriptional accessory protein [Transcription]; Region: Tex; COG2183
298386000580	Tex-like protein N-terminal domain; Region: Tex_N; pfam09371
298386000581	Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732
298386000582	S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685
298386000583	RNA binding site [nucleotide binding]; other site
298386000584	transcription elongation factor GreB; Reviewed; Region: greB; PRK01885
298386000585	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
298386000586	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
298386000587	osmolarity response regulator; Provisional; Region: ompR; PRK09468
298386000588	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386000589	active site
298386000590	phosphorylation site [posttranslational modification]
298386000591	intermolecular recognition site; other site
298386000592	dimerization interface [polypeptide binding]; other site
298386000593	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298386000594	DNA binding site [nucleotide binding]
298386000595	osmolarity sensor protein; Provisional; Region: envZ; PRK09467
298386000596	HAMP domain; Region: HAMP; pfam00672
298386000597	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298386000598	dimer interface [polypeptide binding]; other site
298386000599	phosphorylation site [posttranslational modification]
298386000600	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386000601	ATP binding site [chemical binding]; other site
298386000602	Mg2+ binding site [ion binding]; other site
298386000603	G-X-G motif; other site
298386000604	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
298386000605	ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917
298386000606	RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488
298386000607	ssDNA binding site; other site
298386000608	generic binding surface II; other site
298386000609	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
298386000610	ATP binding site [chemical binding]; other site
298386000611	putative Mg++ binding site [ion binding]; other site
298386000612	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
298386000613	nucleotide binding region [chemical binding]; other site
298386000614	ATP-binding site [chemical binding]; other site
298386000615	tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081
298386000616	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
298386000617	SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105
298386000618	bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092
298386000619	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
298386000620	Zn2+ binding site [ion binding]; other site
298386000621	Mg2+ binding site [ion binding]; other site
298386000622	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
298386000623	synthetase active site [active]
298386000624	NTP binding site [chemical binding]; other site
298386000625	metal binding site [ion binding]; metal-binding site
298386000626	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
298386000627	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
298386000628	DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690
298386000629	Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194
298386000630	Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071
298386000631	catalytic site [active]
298386000632	G-X2-G-X-G-K; other site
298386000633	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298386000634	non-specific DNA binding site [nucleotide binding]; other site
298386000635	salt bridge; other site
298386000636	sequence-specific DNA binding site [nucleotide binding]; other site
298386000637	HipA N-terminal domain; Region: Couple_hipA; pfam13657
298386000638	HipA-like N-terminal domain; Region: HipA_N; pfam07805
298386000639	HipA-like C-terminal domain; Region: HipA_C; pfam07804
298386000640	SEC-C motif; Region: SEC-C; pfam02810
298386000641	Domain of unknown function (DUF3578); Region: DUF3578; pfam12102
298386000642	Domain of unknown function (DUF2357); Region: DUF2357; pfam09823
298386000643	Protein of unknown function (DUF524); Region: DUF524; pfam04411
298386000644	hypothetical protein; Provisional; Region: PRK11820
298386000645	YicC-like family, N-terminal region; Region: YicC_N; pfam03755
298386000646	Domain of unknown function (DUF1732); Region: DUF1732; pfam08340
298386000647	ribonuclease PH; Reviewed; Region: rph; PRK00173
298386000648	Ribonuclease PH; Region: RNase_PH_bact; cd11362
298386000649	hexamer interface [polypeptide binding]; other site
298386000650	active site
298386000651	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
298386000652	active site
298386000653	division inhibitor protein; Provisional; Region: slmA; PRK09480
298386000654	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298386000655	bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579
298386000656	Flavoprotein; Region: Flavoprotein; pfam02441
298386000657	DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127
298386000658	hypothetical protein; Reviewed; Region: PRK00024
298386000659	Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071
298386000660	MPN+ (JAMM) motif; other site
298386000661	Zinc-binding site [ion binding]; other site
298386000662	50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359
298386000663	50S ribosomal protein L33; Validated; Region: rpmG; PRK00595
298386000664	formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103
298386000665	N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966
298386000666	DNA binding site [nucleotide binding]
298386000667	catalytic residue [active]
298386000668	H2TH interface [polypeptide binding]; other site
298386000669	putative catalytic residues [active]
298386000670	turnover-facilitating residue; other site
298386000671	intercalation triad [nucleotide binding]; other site
298386000672	8OG recognition residue [nucleotide binding]; other site
298386000673	putative reading head residues; other site
298386000674	Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831
298386000675	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
298386000676	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
298386000677	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
298386000678	putative NAD(P) binding site [chemical binding]; other site
298386000679	active site
298386000680	putative substrate binding site [chemical binding]; other site
298386000681	phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168
298386000682	Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163
298386000683	active site
298386000684	(T/H)XGH motif; other site
298386000685	ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859
298386000686	Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789
298386000687	putative active site [active]
298386000688	3-deoxy-D-manno-octulosonic-acid kinase; Reviewed; Region: PRK01723
298386000689	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
298386000690	active site
298386000691	ATP binding site [chemical binding]; other site
298386000692	3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749
298386000693	3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413
298386000694	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
298386000695	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
298386000696	UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511
298386000697	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
298386000698	putative metal binding site; other site
298386000699	Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230
298386000700	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
298386000701	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
298386000702	putative ADP-binding pocket [chemical binding]; other site
298386000703	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
298386000704	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
298386000705	Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532
298386000706	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
298386000707	O-Antigen ligase; Region: Wzy_C; pfam04932
298386000708	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
298386000709	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
298386000710	putative acyl-acceptor binding pocket; other site
298386000711	ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248
298386000712	ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150
298386000713	NADP binding site [chemical binding]; other site
298386000714	homopentamer interface [polypeptide binding]; other site
298386000715	substrate binding site [chemical binding]; other site
298386000716	active site
298386000717	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298386000718	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298386000719	Bacterial transcriptional repressor; Region: TetR; pfam13972
298386000720	Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936
298386000721	NodB motif; other site
298386000722	putative active site [active]
298386000723	putative catalytic site [active]
298386000724	Zn binding site [ion binding]; other site
298386000725	AmiB activator; Provisional; Region: PRK11637
298386000726	Peptidase family M23; Region: Peptidase_M23; pfam01551
298386000727	phosphoglyceromutase; Provisional; Region: PRK05434
298386000728	Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696
298386000729	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
298386000730	active site residue [active]
298386000731	Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557
298386000732	SecA binding site; other site
298386000733	Preprotein binding site; other site
298386000734	NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094
298386000735	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
298386000736	NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479
298386000737	serine acetyltransferase; Provisional; Region: cysE; PRK11132
298386000738	Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426
298386000739	Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354
298386000740	trimer interface [polypeptide binding]; other site
298386000741	active site
298386000742	substrate binding site [chemical binding]; other site
298386000743	CoA binding site [chemical binding]; other site
298386000744	Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219
298386000745	two-component sensor protein; Provisional; Region: cpxA; PRK09470
298386000746	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298386000747	dimerization interface [polypeptide binding]; other site
298386000748	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298386000749	dimer interface [polypeptide binding]; other site
298386000750	phosphorylation site [posttranslational modification]
298386000751	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386000752	ATP binding site [chemical binding]; other site
298386000753	Mg2+ binding site [ion binding]; other site
298386000754	G-X-G motif; other site
298386000755	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386000756	active site
298386000757	dimerization interface [polypeptide binding]; other site
298386000758	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298386000759	DNA binding site [nucleotide binding]
298386000760	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386000761	active site
298386000762	phosphorylation site [posttranslational modification]
298386000763	intermolecular recognition site; other site
298386000764	CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916
298386000765	dimer interface [polypeptide binding]; other site
298386000766	Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763
298386000767	6-phosphofructokinase; Region: PFKA_ATP; TIGR02482
298386000768	active site
298386000769	ADP/pyrophosphate binding site [chemical binding]; other site
298386000770	dimerization interface [polypeptide binding]; other site
298386000771	allosteric effector site; other site
298386000772	fructose-1,6-bisphosphate binding site; other site
298386000773	Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311
298386000774	substrate binding site [chemical binding]; other site
298386000775	dimer interface [polypeptide binding]; other site
298386000776	catalytic triad [active]
298386000777	5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580
298386000778	putative substrate binding pocket [chemical binding]; other site
298386000779	trimer interface [polypeptide binding]; other site
298386000780	Protein of unknown function (DUF3135); Region: DUF3135; pfam11333
298386000781	ferredoxin-NADP reductase; Provisional; Region: PRK10926
298386000782	Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195
298386000783	FAD binding pocket [chemical binding]; other site
298386000784	FAD binding motif [chemical binding]; other site
298386000785	phosphate binding motif [ion binding]; other site
298386000786	beta-alpha-beta structure motif; other site
298386000787	NAD binding pocket [chemical binding]; other site
298386000788	Predicted transcriptional regulator [Transcription]; Region: COG2345
298386000789	Transcriptional regulator PadR-like family; Region: PadR; cl17335
298386000790	Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516
298386000791	Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320
298386000792	putative active site [active]
298386000793	TcdA/TcdB catalytic glycosyltransferase domain; Region: TcdA_TcdB; pfam12919
298386000794	Glycosyltransferase sugar-binding region containing DXD motif; Region: Gly_transf_sug; pfam04488
298386000795	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386000796	HlyD family secretion protein; Region: HlyD_3; pfam13437
298386000797	ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274
298386000798	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419
298386000799	putative active site [active]
298386000800	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
298386000801	ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246
298386000802	Walker A/P-loop; other site
298386000803	ATP binding site [chemical binding]; other site
298386000804	Q-loop/lid; other site
298386000805	ABC transporter signature motif; other site
298386000806	Walker B; other site
298386000807	D-loop; other site
298386000808	H-loop/switch region; other site
298386000809	glycerol kinase; Provisional; Region: glpK; PRK00047
298386000810	Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786
298386000811	N- and C-terminal domain interface [polypeptide binding]; other site
298386000812	active site
298386000813	MgATP binding site [chemical binding]; other site
298386000814	catalytic site [active]
298386000815	metal binding site [ion binding]; metal-binding site
298386000816	glycerol binding site [chemical binding]; other site
298386000817	homotetramer interface [polypeptide binding]; other site
298386000818	homodimer interface [polypeptide binding]; other site
298386000819	FBP binding site [chemical binding]; other site
298386000820	protein IIAGlc interface [polypeptide binding]; other site
298386000821	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
298386000822	amphipathic channel; other site
298386000823	Asn-Pro-Ala signature motifs; other site
298386000824	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3074
298386000825	ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372
298386000826	1,4-dihydroxy-2-naphthoate octaprenyltransferase; Validated; Region: PRK06080
298386000827	UbiA prenyltransferase family; Region: UbiA; pfam01040
298386000828	ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201
298386000829	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298386000830	Walker A motif; other site
298386000831	ATP binding site [chemical binding]; other site
298386000832	AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724
298386000833	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
298386000834	Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913
298386000835	active site
298386000836	HslU subunit interaction site [polypeptide binding]; other site
298386000837	Cell division protein [Cell division and chromosome partitioning]; Region: FtsN; COG3087
298386000838	Sporulation related domain; Region: SPOR; cl10051
298386000839	Sporulation related domain; Region: SPOR; pfam05036
298386000840	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
298386000841	DNA binding site [nucleotide binding]
298386000842	DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041
298386000843	domain linker motif; other site
298386000844	Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284
298386000845	dimerization interface [polypeptide binding]; other site
298386000846	ligand binding site [chemical binding]; other site
298386000847	primosome assembly protein PriA; Validated; Region: PRK05580
298386000848	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
298386000849	ATP binding site [chemical binding]; other site
298386000850	putative Mg++ binding site [ion binding]; other site
298386000851	helicase superfamily c-terminal domain; Region: HELICc; smart00490
298386000852	ATP-binding site [chemical binding]; other site
298386000853	50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019
298386000854	Malic enzyme [Energy production and conversion]; Region: SfcA; COG0281
298386000855	Malic enzyme, N-terminal domain; Region: malic; pfam00390
298386000856	NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311
298386000857	putative NAD(P) binding site [chemical binding]; other site
298386000858	Met Repressor, MetJ.  MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490
298386000859	dimerization interface [polypeptide binding]; other site
298386000860	DNA binding site [nucleotide binding]
298386000861	corepressor binding sites; other site
298386000862	cystathionine gamma-synthase; Provisional; Region: PRK08861
298386000863	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
298386000864	homodimer interface [polypeptide binding]; other site
298386000865	substrate-cofactor binding pocket; other site
298386000866	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298386000867	catalytic residue [active]
298386000868	bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466
298386000869	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
298386000870	nucleotide binding site [chemical binding]; other site
298386000871	substrate binding site [chemical binding]; other site
298386000872	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
298386000873	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
298386000874	Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537
298386000875	FAD binding site [chemical binding]; other site
298386000876	Predicted transcriptional regulators [Transcription]; Region: COG1695
298386000877	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
298386000878	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
298386000879	phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009
298386000880	Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352
298386000881	N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436
298386000882	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
298386000883	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
298386000884	nucleotide binding site [chemical binding]; other site
298386000885	substrate binding site [chemical binding]; other site
298386000886	argininosuccinate synthase; Provisional; Region: PRK13820
298386000887	Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate .  In...; Region: Argininosuccinate_Synthase; cd01999
298386000888	ANP binding site [chemical binding]; other site
298386000889	Substrate Binding Site II [chemical binding]; other site
298386000890	Substrate Binding Site I [chemical binding]; other site
298386000891	bifunctional argininosuccinate lyase/N-acetylglutamate synthase; Provisional; Region: PRK12308
298386000892	Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359
298386000893	active sites [active]
298386000894	tetramer interface [polypeptide binding]; other site
298386000895	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298386000896	Coenzyme A binding pocket [chemical binding]; other site
298386000897	Protein of unknown function (DUF3624); Region: DUF3624; pfam12292
298386000898	dihydrolipoamide dehydrogenase; Validated; Region: PRK06292
298386000899	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
298386000900	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
298386000901	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
298386000902	Peroxiredoxin (PRX) family, PRX5-like subfamily; members are similar to the human protein, PRX5, a homodimeric TRX peroxidase, widely expressed in tissues and found cellularly in mitochondria, peroxisomes and the cytosol. The cellular location of PRX5...; Region: PRX5_like; cd03013
298386000903	catalytic triad [active]
298386000904	dimer interface [polypeptide binding]; other site
298386000905	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
298386000906	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
298386000907	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386000908	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
298386000909	dimerization interface [polypeptide binding]; other site
298386000910	penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636
298386000911	Transglycosylase; Region: Transgly; pfam00912
298386000912	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
298386000913	Competence protein A; Region: Competence_A; pfam11104
298386000914	Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166
298386000915	Fimbrial assembly protein (PilN); Region: PilN; pfam05137
298386000916	Pilus assembly protein, PilO; Region: PilO; pfam04350
298386000917	Tfp pilus assembly protein PilP [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilP; COG3168
298386000918	Pilus assembly protein, PilP; Region: PilP; pfam04351
298386000919	type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515
298386000920	Secretin and TonB N terminus short domain; Region: STN; smart00965
298386000921	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
298386000922	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
298386000923	shikimate kinase; Reviewed; Region: aroK; PRK00131
298386000924	Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464
298386000925	ADP binding site [chemical binding]; other site
298386000926	magnesium binding site [ion binding]; other site
298386000927	putative shikimate binding site; other site
298386000928	Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195
298386000929	active site
298386000930	dimer interface [polypeptide binding]; other site
298386000931	metal binding site [ion binding]; metal-binding site
298386000932	AAA ATPase domain; Region: AAA_16; pfam13191
298386000933	AAA domain; Region: AAA_22; pfam13401
298386000934	cell division protein DamX; Validated; Region: PRK10905
298386000935	D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344
298386000936	Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429
298386000937	ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163
298386000938	substrate binding site [chemical binding]; other site
298386000939	hexamer interface [polypeptide binding]; other site
298386000940	metal binding site [ion binding]; metal-binding site
298386000941	phosphoglycolate phosphatase; Provisional; Region: PRK13222
298386000942	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
298386000943	motif II; other site
298386000944	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
298386000945	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
298386000946	active site
298386000947	HIGH motif; other site
298386000948	dimer interface [polypeptide binding]; other site
298386000949	KMSKS motif; other site
298386000950	YhcR_OBF_like: A subfamily of OB-fold domains similar to the OB folds of Bacillus subtilis YhcR. YhcR is a sugar-nonspecific nuclease, which is active in the presence of Ca2+ and Mn2+. It cleaves RNA endonucleolytically, producing 3'-monophosphate...; Region: YhcR_OBF_like; cd04486
298386000951	generic binding surface I; other site
298386000952	generic binding surface II; other site
298386000953	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
298386000954	putative catalytic site [active]
298386000955	putative metal binding site [ion binding]; other site
298386000956	putative phosphate binding site [ion binding]; other site
298386000957	para-aminobenzoate synthase component II; Provisional; Region: PRK08857
298386000958	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
298386000959	glutamine binding [chemical binding]; other site
298386000960	catalytic triad [active]
298386000961	bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093
298386000962	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
298386000963	inhibitor-cofactor binding pocket; inhibition site
298386000964	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298386000965	catalytic residue [active]
298386000966	Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138
298386000967	Arginine N-succinyltransferase beta subunit; Region: AstA; pfam04958
298386000968	succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457
298386000969	N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095
298386000970	NAD(P) binding site [chemical binding]; other site
298386000971	catalytic residues [active]
298386000972	Domain of unknown function (DUF1338); Region: DUF1338; pfam07063
298386000973	DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753
298386000974	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
298386000975	ligand binding site [chemical binding]; other site
298386000976	flexible hinge region; other site
298386000977	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
298386000978	putative switch regulator; other site
298386000979	non-specific DNA interactions [nucleotide binding]; other site
298386000980	DNA binding site [nucleotide binding]
298386000981	sequence specific DNA binding site [nucleotide binding]; other site
298386000982	putative cAMP binding site [chemical binding]; other site
298386000983	OsmC-like protein; Region: OsmC; cl00767
298386000984	phosphoribulokinase; Provisional; Region: PRK15453
298386000985	active site
298386000986	hypothetical protein; Provisional; Region: PRK04966
298386000987	putative hydrolase; Provisional; Region: PRK10985
298386000988	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
298386000989	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298386000990	DNA-binding site [nucleotide binding]; DNA binding site
298386000991	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
298386000992	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298386000993	homodimer interface [polypeptide binding]; other site
298386000994	catalytic residue [active]
298386000995	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
298386000996	Protein of unknown function (DUF2390); Region: DUF2390; pfam09523
298386000997	putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636
298386000998	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
298386000999	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
298386001000	ABC transporter; Region: ABC_tran_2; pfam12848
298386001001	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
298386001002	glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930
298386001003	glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659
298386001004	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
298386001005	TrkA-N domain; Region: TrkA_N; pfam02254
298386001006	Probable metal-binding protein (DUF2387); Region: DUF2387; pfam09526
298386001007	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10737
298386001008	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
298386001009	SlyX; Region: SlyX; pfam04102
298386001010	FOG: WD40 repeat [General function prediction only]; Region: COG2319
298386001011	WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567
298386001012	structural tetrad; other site
298386001013	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
298386001014	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
298386001015	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
298386001016	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
298386001017	YheO-like PAS domain; Region: PAS_6; pfam08348
298386001018	HTH domain; Region: HTH_22; pfam13309
298386001019	sulfur transfer complex subunit TusD; Validated; Region: PRK00207
298386001020	sulfur relay protein TusC/DsrF; Region: sulf_tusC_dsrF; TIGR03010
298386001021	sulfur relay protein TusB/DsrH; Region: sulf_tusB_dsrH; TIGR03011
298386001022	S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368
298386001023	S17 interaction site [polypeptide binding]; other site
298386001024	S8 interaction site; other site
298386001025	16S rRNA interaction site [nucleotide binding]; other site
298386001026	streptomycin interaction site [chemical binding]; other site
298386001027	23S rRNA interaction site [nucleotide binding]; other site
298386001028	aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site
298386001029	30S ribosomal protein S7; Validated; Region: PRK05302
298386001030	elongation factor G; Reviewed; Region: PRK00007
298386001031	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
298386001032	G1 box; other site
298386001033	putative GEF interaction site [polypeptide binding]; other site
298386001034	GTP/Mg2+ binding site [chemical binding]; other site
298386001035	Switch I region; other site
298386001036	G2 box; other site
298386001037	G3 box; other site
298386001038	Switch II region; other site
298386001039	G4 box; other site
298386001040	G5 box; other site
298386001041	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
298386001042	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
298386001043	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
298386001044	elongation factor Tu; Reviewed; Region: PRK00049
298386001045	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
298386001046	G1 box; other site
298386001047	GEF interaction site [polypeptide binding]; other site
298386001048	GTP/Mg2+ binding site [chemical binding]; other site
298386001049	Switch I region; other site
298386001050	G2 box; other site
298386001051	G3 box; other site
298386001052	Switch II region; other site
298386001053	G4 box; other site
298386001054	G5 box; other site
298386001055	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
298386001056	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
298386001057	Antibiotic Binding Site [chemical binding]; other site
298386001058	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093
298386001059	Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193
298386001060	Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907
298386001061	heme binding site [chemical binding]; other site
298386001062	ferroxidase pore; other site
298386001063	ferroxidase diiron center [ion binding]; other site
298386001064	30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596
298386001065	50S ribosomal protein L3; Validated; Region: rplC; PRK00001
298386001066	50S ribosomal protein L4; Provisional; Region: rplD; PRK05319
298386001067	50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738
298386001068	50S ribosomal protein L2; Validated; Region: rplB; PRK09374
298386001069	Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181
298386001070	Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947
298386001071	30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357
298386001072	Ribosomal protein L22/L17e.  L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit.  It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336
298386001073	putative translocon binding site; other site
298386001074	protein-rRNA interface [nucleotide binding]; other site
298386001075	30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310
298386001076	K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3  is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel.  The KH...; Region: 30S_S3_KH; cd02412
298386001077	G-X-X-G motif; other site
298386001078	Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189
298386001079	Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433
298386001080	23S rRNA interface [nucleotide binding]; other site
298386001081	5S rRNA interface [nucleotide binding]; other site
298386001082	putative antibiotic binding site [chemical binding]; other site
298386001083	L25 interface [polypeptide binding]; other site
298386001084	L27 interface [polypeptide binding]; other site
298386001085	Ribosomal L29 protein/HIP.  L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals.  L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427
298386001086	putative translocon interaction site; other site
298386001087	23S rRNA interface [nucleotide binding]; other site
298386001088	signal recognition particle (SRP54) interaction site; other site
298386001089	L23 interface [polypeptide binding]; other site
298386001090	trigger factor interaction site; other site
298386001091	30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610
298386001092	50S ribosomal protein L14; Validated; Region: rplN; PRK05483
298386001093	50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004
298386001094	KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089
298386001095	RNA binding site [nucleotide binding]; other site
298386001096	50S ribosomal protein L5; Validated; Region: rplE; PRK00010
298386001097	Ribosomal protein L5; Region: Ribosomal_L5; pfam00281
298386001098	ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673
298386001099	30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881
298386001100	30S ribosomal protein S8; Validated; Region: rpsH; PRK00136
298386001101	50S ribosomal protein L6; Validated; Region: rplF; PRK05498
298386001102	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
298386001103	Ribosomal protein L6; Region: Ribosomal_L6; pfam00347
298386001104	Ribosomal L18/L5e:  L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432
298386001105	5S rRNA interface [nucleotide binding]; other site
298386001106	L5 interface [polypeptide binding]; other site
298386001107	30S ribosomal protein S5; Validated; Region: rpsE; PRK00550
298386001108	Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333
298386001109	Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719
298386001110	Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658
298386001111	23S rRNA binding site [nucleotide binding]; other site
298386001112	50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592
298386001113	preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204
298386001114	SecY translocase; Region: SecY; pfam00344
298386001115	50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465
298386001116	30S ribosomal protein S13; Validated; Region: rpsM; PRK05179
298386001117	30S ribosomal protein S13; Region: bact_S13; TIGR03631
298386001118	30S ribosomal protein S11; Validated; Region: PRK05309
298386001119	30S ribosomal protein S4; Validated; Region: rpsD; PRK05327
298386001120	Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163
298386001121	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
298386001122	RNA binding surface [nucleotide binding]; other site
298386001123	DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182
298386001124	N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928
298386001125	alphaNTD homodimer interface [polypeptide binding]; other site
298386001126	alphaNTD - beta interaction site [polypeptide binding]; other site
298386001127	alphaNTD - beta' interaction site [polypeptide binding]; other site
298386001128	Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118
298386001129	50S ribosomal protein L17; Validated; Region: rplQ; PRK05591
298386001130	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
298386001131	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
298386001132	AAA domain; Region: AAA_31; pfam13614
298386001133	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
298386001134	putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027
298386001135	SLBB domain; Region: SLBB; pfam10531
298386001136	SLBB domain; Region: SLBB; pfam10531
298386001137	SLBB domain; Region: SLBB; pfam10531
298386001138	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
298386001139	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
298386001140	polysaccharide export protein EpsE; Region: EpsE; TIGR03028
298386001141	SLBB domain; Region: SLBB; pfam10531
298386001142	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
298386001143	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
298386001144	ligand binding site [chemical binding]; other site
298386001145	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
298386001146	anti sigma factor interaction site; other site
298386001147	regulatory phosphorylation site [posttranslational modification]; other site
298386001148	Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215
298386001149	CESA_like_1 is a member of the cellulose synthase (CESA) superfamily; Region: CESA_like_1; cd06439
298386001150	DXD motif; other site
298386001151	Bacterial sugar transferase; Region: Bac_transf; pfam02397
298386001152	sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088
298386001153	This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801
298386001154	polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007
298386001155	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: GT1_like_1; cd04950
298386001156	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
298386001157	putative homodimer interface [polypeptide binding]; other site
298386001158	O-Antigen ligase; Region: Wzy_C; cl04850
298386001159	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
298386001160	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
298386001161	DDE superfamily endonuclease; Region: DDE_3; pfam13358
298386001162	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
298386001163	Homeodomain-like domain; Region: HTH_23; pfam13384
298386001164	Winged helix-turn helix; Region: HTH_29; pfam13551
298386001165	Winged helix-turn helix; Region: HTH_33; pfam13592
298386001166	DDE superfamily endonuclease; Region: DDE_3; pfam13358
298386001167	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
298386001168	homoserine O-succinyltransferase; Provisional; Region: PRK05368
298386001169	Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131
298386001170	proposed active site lysine [active]
298386001171	conserved cys residue [active]
298386001172	TIGR03899 family protein; Region: TIGR03899
298386001173	Protein of unknown function (DUF3299); Region: DUF3299; pfam11736
298386001174	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
298386001175	FtsX-like permease family; Region: FtsX; pfam02687
298386001176	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
298386001177	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
298386001178	Walker A/P-loop; other site
298386001179	ATP binding site [chemical binding]; other site
298386001180	Q-loop/lid; other site
298386001181	ABC transporter signature motif; other site
298386001182	Walker B; other site
298386001183	D-loop; other site
298386001184	H-loop/switch region; other site
298386001185	Protein of unknown function (DUF2796); Region: DUF2796; pfam10986
298386001186	Protein of unknown function (DUF2796); Region: DUF2796; pfam10986
298386001187	Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695
298386001188	Protein of unknown function (DUF1107); Region: DUF1107; pfam06526
298386001189	methionine sulfoxide reductase A; Provisional; Region: PRK00058
298386001190	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
298386001191	Surface antigen; Region: Bac_surface_Ag; pfam01103
298386001192	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911
298386001193	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
298386001194	Family of unknown function (DUF490); Region: DUF490; pfam04357
298386001195	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
298386001196	dimerization interface [polypeptide binding]; other site
298386001197	putative active site pocket [active]
298386001198	putative catalytic residue [active]
298386001199	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
298386001200	active site residue [active]
298386001201	Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412
298386001202	dimer interface [polypeptide binding]; other site
298386001203	substrate binding site [chemical binding]; other site
298386001204	metal binding sites [ion binding]; metal-binding site
298386001205	Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate  into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354
298386001206	AMP binding site [chemical binding]; other site
298386001207	metal binding site [ion binding]; metal-binding site
298386001208	active site
298386001209	UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081
298386001210	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
298386001211	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
298386001212	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
298386001213	aromatic acid decarboxylase; Validated; Region: PRK05920
298386001214	Flavoprotein; Region: Flavoprotein; pfam02441
298386001215	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
298386001216	Ligand Binding Site [chemical binding]; other site
298386001217	TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666
298386001218	TRAP-type uncharacterized transport system, fused permease components [General function prediction only]; Region: COG4666
298386001219	Domain of unknown function (DUF3394); Region: DUF3394; pfam11874
298386001220	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
298386001221	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
298386001222	arginine repressor; Provisional; Region: PRK05066
298386001223	Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316
298386001224	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
298386001225	malate dehydrogenase; Provisional; Region: PRK05086
298386001226	Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337
298386001227	NAD binding site [chemical binding]; other site
298386001228	dimerization interface [polypeptide binding]; other site
298386001229	Substrate binding site [chemical binding]; other site
298386001230	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
298386001231	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
298386001232	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
298386001233	substrate binding pocket [chemical binding]; other site
298386001234	chain length determination region; other site
298386001235	substrate-Mg2+ binding site; other site
298386001236	catalytic residues [active]
298386001237	aspartate-rich region 1; other site
298386001238	active site lid residues [active]
298386001239	aspartate-rich region 2; other site
298386001240	50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278
298386001241	50S ribosomal protein L21; Validated; Region: rplU; PRK05573
298386001242	50S ribosomal protein L27; Validated; Region: rpmA; PRK05435
298386001243	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
298386001244	EamA-like transporter family; Region: EamA; pfam00892
298386001245	GTPase CgtA; Reviewed; Region: obgE; PRK12298
298386001246	GTP1/OBG; Region: GTP1_OBG; pfam01018
298386001247	Obg GTPase; Region: Obg; cd01898
298386001248	G1 box; other site
298386001249	GTP/Mg2+ binding site [chemical binding]; other site
298386001250	Switch I region; other site
298386001251	G2 box; other site
298386001252	G3 box; other site
298386001253	Switch II region; other site
298386001254	G4 box; other site
298386001255	G5 box; other site
298386001256	Uncharacterized conserved protein [Function unknown]; Region: COG2966
298386001257	Protein of unknown function (DUF1212); Region: DUF1212; pfam06738
298386001258	Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262
298386001259	Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209
298386001260	folate binding site [chemical binding]; other site
298386001261	NADP+ binding site [chemical binding]; other site
298386001262	diadenosine tetraphosphatase; Reviewed; Region: apaH; PRK00166
298386001263	Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422
298386001264	active site
298386001265	metal binding site [ion binding]; metal-binding site
298386001266	CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461
298386001267	16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274
298386001268	Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030
298386001269	4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232
298386001270	4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743
298386001271	peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770
298386001272	SurA N-terminal domain; Region: SurA_N; pfam09312
298386001273	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
298386001274	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
298386001275	LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761
298386001276	OstA-like protein; Region: OstA; pfam03968
298386001277	Organic solvent tolerance protein; Region: OstA_C; pfam04453
298386001278	Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430
298386001279	N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316
298386001280	putative metal binding site [ion binding]; other site
298386001281	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
298386001282	HSP70 interaction site [polypeptide binding]; other site
298386001283	glycerate dehydrogenase; Provisional; Region: PRK06932
298386001284	Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162
298386001285	putative ligand binding site [chemical binding]; other site
298386001286	putative NAD binding site [chemical binding]; other site
298386001287	catalytic site [active]
298386001288	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
298386001289	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
298386001290	active site
298386001291	ATP-dependent helicase HepA; Validated; Region: PRK04914
298386001292	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
298386001293	ATP binding site [chemical binding]; other site
298386001294	putative Mg++ binding site [ion binding]; other site
298386001295	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
298386001296	nucleotide binding region [chemical binding]; other site
298386001297	ATP-binding site [chemical binding]; other site
298386001298	NYN ribonuclease and ATPase of PhoH family domains [General    function prediction only]; Region: COG1875
298386001299	PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883
298386001300	putative active site [active]
298386001301	PhoH-like protein; Region: PhoH; pfam02562
298386001302	ABC-type thiamine transport system, ATPase component [Coenzyme metabolism]; Region: ThiQ; COG3840
298386001303	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298386001304	Walker A/P-loop; other site
298386001305	ATP binding site [chemical binding]; other site
298386001306	Q-loop/lid; other site
298386001307	ABC transporter signature motif; other site
298386001308	Walker B; other site
298386001309	D-loop; other site
298386001310	H-loop/switch region; other site
298386001311	thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433
298386001312	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386001313	dimer interface [polypeptide binding]; other site
298386001314	conserved gate region; other site
298386001315	putative PBP binding loops; other site
298386001316	ABC-ATPase subunit interface; other site
298386001317	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386001318	dimer interface [polypeptide binding]; other site
298386001319	conserved gate region; other site
298386001320	putative PBP binding loops; other site
298386001321	ABC-ATPase subunit interface; other site
298386001322	ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143
298386001323	thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205
298386001324	Protein of unknown function, DUF547; Region: DUF547; pfam04784
298386001325	isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641
298386001326	Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577
298386001327	substrate binding site [chemical binding]; other site
298386001328	3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402
298386001329	3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583
298386001330	substrate binding site [chemical binding]; other site
298386001331	ligand binding site [chemical binding]; other site
298386001332	3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772
298386001333	tartrate dehydrogenase; Region: TTC; TIGR02089
298386001334	2-isopropylmalate synthase; Validated; Region: PRK00915
298386001335	2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940
298386001336	active site
298386001337	catalytic residues [active]
298386001338	metal binding site [ion binding]; metal-binding site
298386001339	LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502
298386001340	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298386001341	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298386001342	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
298386001343	HlyD family secretion protein; Region: HlyD_3; pfam13437
298386001344	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
298386001345	Protein export membrane protein; Region: SecD_SecF; cl14618
298386001346	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
298386001347	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386001348	The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466
298386001349	putative substrate binding pocket [chemical binding]; other site
298386001350	putative dimerization interface [polypeptide binding]; other site
298386001351	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
298386001352	Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907
298386001353	acyl-activating enzyme (AAE) consensus motif; other site
298386001354	putative AMP binding site [chemical binding]; other site
298386001355	putative active site [active]
298386001356	putative CoA binding site [chemical binding]; other site
298386001357	acetolactate synthase 3 catalytic subunit; Validated; Region: PRK08979
298386001358	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
298386001359	PYR/PP interface [polypeptide binding]; other site
298386001360	dimer interface [polypeptide binding]; other site
298386001361	TPP binding site [chemical binding]; other site
298386001362	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
298386001363	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
298386001364	TPP-binding site [chemical binding]; other site
298386001365	dimer interface [polypeptide binding]; other site
298386001366	acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895
298386001367	N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878
298386001368	putative valine binding site [chemical binding]; other site
298386001369	dimer interface [polypeptide binding]; other site
298386001370	Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369
298386001371	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298386001372	DNA-binding site [nucleotide binding]; DNA binding site
298386001373	DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534
298386001374	FCD domain; Region: FCD; pfam07729
298386001375	pyruvate kinase; Provisional; Region: PRK09206
298386001376	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288
298386001377	domain interfaces; other site
298386001378	active site
298386001379	RNA polymerase sigma factor RpoD; Validated; Region: PRK05658
298386001380	Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979
298386001381	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
298386001382	Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546
298386001383	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298386001384	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
298386001385	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
298386001386	DNA binding residues [nucleotide binding]
298386001387	DNA primase; Validated; Region: dnaG; PRK05667
298386001388	CHC2 zinc finger; Region: zf-CHC2; pfam01807
298386001389	DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275
298386001390	TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364
298386001391	active site
298386001392	metal binding site [ion binding]; metal-binding site
298386001393	interdomain interaction site; other site
298386001394	DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410
298386001395	DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278
298386001396	Yqey-like protein; Region: YqeY; pfam09424
298386001397	30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270
298386001398	UGMP family protein; Validated; Region: PRK09604
298386001399	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
298386001400	putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220
298386001401	Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534
298386001402	homooctamer interface [polypeptide binding]; other site
298386001403	active site
298386001404	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
298386001405	catalytic center binding site [active]
298386001406	ATP binding site [chemical binding]; other site
298386001407	Bacitracin resistance protein BacA; Region: BacA; pfam02673
298386001408	multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885
298386001409	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
298386001410	active site
298386001411	NTP binding site [chemical binding]; other site
298386001412	metal binding triad [ion binding]; metal-binding site
298386001413	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
298386001414	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
298386001415	Zn2+ binding site [ion binding]; other site
298386001416	Mg2+ binding site [ion binding]; other site
298386001417	putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015
298386001418	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298386001419	Walker A motif; other site
298386001420	ATP binding site [chemical binding]; other site
298386001421	Walker B motif; other site
298386001422	arginine finger; other site
298386001423	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
298386001424	SH3 domain-containing protein; Provisional; Region: PRK10884
298386001425	Bacterial SH3 domain homologues; Region: SH3b; smart00287
298386001426	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
298386001427	Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306
298386001428	Phosphate transport regulator (distant homolog of PhoU) [Inorganic ion transport and metabolism]; Region: COG1392
298386001429	Uncharacterized conserved protein [Function unknown]; Region: COG3025
298386001430	Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756
298386001431	putative active site [active]
298386001432	putative metal binding residues [ion binding]; other site
298386001433	signature motif; other site
298386001434	putative triphosphate binding site [ion binding]; other site
298386001435	The CHAD domain is an alpha-helical domain functionally associated with some members of the adenylate cyclase family; Region: CHAD; smart00880
298386001436	Ion transport protein; Region: Ion_trans; pfam00520
298386001437	Ion channel; Region: Ion_trans_2; pfam07885
298386001438	HAMP domain; Region: HAMP; pfam00672
298386001439	dimerization interface [polypeptide binding]; other site
298386001440	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
298386001441	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
298386001442	dimer interface [polypeptide binding]; other site
298386001443	putative CheW interface [polypeptide binding]; other site
298386001444	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
298386001445	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
298386001446	metal binding triad; other site
298386001447	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
298386001448	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
298386001449	metal binding triad; other site
298386001450	bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316
298386001451	RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172
298386001452	putative ribose interaction site [chemical binding]; other site
298386001453	putative ADP binding site [chemical binding]; other site
298386001454	rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199
298386001455	active site
298386001456	nucleotide binding site [chemical binding]; other site
298386001457	HIGH motif; other site
298386001458	KMSKS motif; other site
298386001459	outer membrane channel protein; Reviewed; Region: tolC; PRK09465
298386001460	ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729
298386001461	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
298386001462	dimer interface [polypeptide binding]; other site
298386001463	ADP-ribose binding site [chemical binding]; other site
298386001464	active site
298386001465	nudix motif; other site
298386001466	metal binding site [ion binding]; metal-binding site
298386001467	putative dehydrogenase; Provisional; Region: PRK11039
298386001468	Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402
298386001469	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
298386001470	active site
298386001471	metal binding site [ion binding]; metal-binding site
298386001472	hexamer interface [polypeptide binding]; other site
298386001473	esterase YqiA; Provisional; Region: PRK11071
298386001474	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
298386001475	DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559
298386001476	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386001477	ATP binding site [chemical binding]; other site
298386001478	Mg2+ binding site [ion binding]; other site
298386001479	G-X-G motif; other site
298386001480	TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822
298386001481	anchoring element; other site
298386001482	dimer interface [polypeptide binding]; other site
298386001483	ATP binding site [chemical binding]; other site
298386001484	Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718
298386001485	active site
298386001486	metal binding site [ion binding]; metal-binding site
298386001487	DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986
298386001488	DNA topoisomerase IV subunit A; Validated; Region: PRK05561
298386001489	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
298386001490	CAP-like domain; other site
298386001491	active site
298386001492	primary dimer interface [polypeptide binding]; other site
298386001493	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
298386001494	xylose isomerase; Provisional; Region: PRK05474
298386001495	xylose isomerase; Region: xylose_isom_A; TIGR02630
298386001496	putative symporter YagG; Provisional; Region: PRK09669
298386001497	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298386001498	putative substrate translocation pore; other site
298386001499	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
298386001500	active site
298386001501	catalytic residues [active]
298386001502	Transcriptional regulators [Transcription]; Region: PurR; COG1609
298386001503	Periplasmic binding protein-like domain; Region: Peripla_BP_3; pfam13377
298386001504	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
298386001505	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298386001506	beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098
298386001507	Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933
298386001508	Fibronectin type III-like domain; Region: Fn3-like; pfam14310
298386001509	D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355
298386001510	Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538
298386001511	putative ligand binding site [chemical binding]; other site
298386001512	xylose transporter ATP-binding subunit; Provisional; Region: PRK13549
298386001513	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
298386001514	Walker A/P-loop; other site
298386001515	ATP binding site [chemical binding]; other site
298386001516	Q-loop/lid; other site
298386001517	ABC transporter signature motif; other site
298386001518	Walker B; other site
298386001519	D-loop; other site
298386001520	H-loop/switch region; other site
298386001521	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
298386001522	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
298386001523	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
298386001524	TM-ABC transporter signature motif; other site
298386001525	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
298386001526	Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543
298386001527	putative dimerization interface [polypeptide binding]; other site
298386001528	Transcriptional regulators [Transcription]; Region: PurR; COG1609
298386001529	putative ligand binding site [chemical binding]; other site
298386001530	xylulokinase; Provisional; Region: PRK15027
298386001531	Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808
298386001532	N- and C-terminal domain interface [polypeptide binding]; other site
298386001533	active site
298386001534	MgATP binding site [chemical binding]; other site
298386001535	catalytic site [active]
298386001536	metal binding site [ion binding]; metal-binding site
298386001537	xylulose binding site [chemical binding]; other site
298386001538	homodimer interface [polypeptide binding]; other site
298386001539	1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018
298386001540	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
298386001541	putative acyl-acceptor binding pocket; other site
298386001542	Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885
298386001543	isopentenyl-diphosphate delta-isomerase, type 1; Region: IPP_isom_1; TIGR02150
298386001544	active site
298386001545	metal binding site [ion binding]; metal-binding site
298386001546	nudix motif; other site
298386001547	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
298386001548	homotrimer interaction site [polypeptide binding]; other site
298386001549	putative active site [active]
298386001550	arginine repressor; Provisional; Region: PRK05066
298386001551	Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863
298386001552	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
298386001553	aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893
298386001554	Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948
298386001555	Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748
298386001556	Aspartate carbamoyltransferase, catalytic chain [Nucleotide transport and metabolism]; Region: PyrB; COG0540
298386001557	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
298386001558	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
298386001559	ornithine carbamoyltransferase; Validated; Region: PRK02102
298386001560	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
298386001561	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
298386001562	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
298386001563	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
298386001564	putative substrate binding site [chemical binding]; other site
298386001565	nucleotide binding site [chemical binding]; other site
298386001566	nucleotide binding site [chemical binding]; other site
298386001567	homodimer interface [polypeptide binding]; other site
298386001568	arginine deiminase; Provisional; Region: PRK01388
298386001569	Predicted membrane protein [Function unknown]; Region: COG1288
298386001570	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
298386001571	RNase E inhibitor protein; Provisional; Region: PRK11191
298386001572	Protein of unknown function (DUF1260); Region: DUF1260; pfam06877
298386001573	Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250
298386001574	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
298386001575	Transcriptional regulators [Transcription]; Region: MarR; COG1846
298386001576	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
298386001577	putative DNA binding site [nucleotide binding]; other site
298386001578	putative Zn2+ binding site [ion binding]; other site
298386001579	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298386001580	Coenzyme A binding pocket [chemical binding]; other site
298386001581	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
298386001582	Predicted membrane protein [Function unknown]; Region: COG3205
298386001583	Predicted membrane protein (DUF2061); Region: DUF2061; pfam09834
298386001584	valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729
298386001585	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
298386001586	HIGH motif; other site
298386001587	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
298386001588	catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817
298386001589	active site
298386001590	KMSKS motif; other site
298386001591	Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962
298386001592	tRNA binding surface [nucleotide binding]; other site
298386001593	anticodon binding site; other site
298386001594	Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458
298386001595	multifunctional aminopeptidase A; Provisional; Region: PRK00913
298386001596	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
298386001597	interface (dimer of trimers) [polypeptide binding]; other site
298386001598	Substrate-binding/catalytic site; other site
298386001599	Zn-binding sites [ion binding]; other site
298386001600	Predicted permeases [General function prediction only]; Region: COG0795; cl12074
298386001601	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
298386001602	lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071
298386001603	Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739
298386001604	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
298386001605	RDD family; Region: RDD; pfam06271
298386001606	Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726
298386001607	Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692
298386001608	chitin-binding domain of Chi A1-like proteins; Region: ChiA1_BD; cd12214
298386001609	Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046
298386001610	aromatic chitin/cellulose binding site residues [chemical binding]; other site
298386001611	PTS_IIB: subunit IIB of enzyme II (EII) is the central energy-coupling domain of the phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In the multienzyme PTS complex, EII is a carbohydrate-specific permease consisting of two cytoplasmic...; Region: PTS_IIB; cl10014
298386001612	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
298386001613	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
298386001614	Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486
298386001615	Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296
298386001616	NAD binding site [chemical binding]; other site
298386001617	sugar binding site [chemical binding]; other site
298386001618	divalent metal binding site [ion binding]; other site
298386001619	tetramer (dimer of dimers) interface [polypeptide binding]; other site
298386001620	dimer interface [polypeptide binding]; other site
298386001621	Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803
298386001622	putative active site [active]
298386001623	YdjC motif; other site
298386001624	Mg binding site [ion binding]; other site
298386001625	putative homodimer interface [polypeptide binding]; other site
298386001626	Transcriptional regulators [Transcription]; Region: PurR; COG1609
298386001627	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
298386001628	DNA binding site [nucleotide binding]
298386001629	domain linker motif; other site
298386001630	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298386001631	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298386001632	Transcriptional regulators [Transcription]; Region: PurR; COG1609
298386001633	Protein of unknown function (DUF533); Region: DUF533; pfam04391
298386001634	tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178
298386001635	putative metal binding site [ion binding]; other site
298386001636	Integrase core domain; Region: rve; pfam00665
298386001637	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
298386001638	Transposase; Region: DEDD_Tnp_IS110; pfam01548
298386001639	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
298386001640	DDE superfamily endonuclease; Region: DDE_3; pfam13358
298386001641	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
298386001642	Homeodomain-like domain; Region: HTH_23; pfam13384
298386001643	Winged helix-turn helix; Region: HTH_29; pfam13551
298386001644	Winged helix-turn helix; Region: HTH_33; pfam13592
298386001645	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386001646	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
298386001647	Transposase; Region: HTH_Tnp_1; cl17663
298386001648	Transposase; Region: HTH_Tnp_1; cl17663
298386001649	Phosphomannomutase [Carbohydrate transport and metabolism]; Region: {ManB}; COG1109
298386001650	This PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily and is found in both archaea and bacteria. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible...; Region: PGM_like2; cd05800
298386001651	active site
298386001652	substrate binding site [chemical binding]; other site
298386001653	metal binding site [ion binding]; metal-binding site
298386001654	Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459
298386001655	N-terminal domain of chitobiose phosphorylase (ChBP) and similar proteins; Region: GH94N_ChBP_like; cd11755
298386001656	catalytic domain interface [polypeptide binding]; other site
298386001657	putative homodimer interface [polypeptide binding]; other site
298386001658	Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592
298386001659	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
298386001660	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin.  Chitin is degraded by a two step process: i)...; Region: GH20_chitobiase-like; cd06563
298386001661	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
298386001662	active site
298386001663	Predicted N-acetylglucosamine kinase [Carbohydrate transport and metabolism]; Region: COG2971
298386001664	N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850
298386001665	Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959
298386001666	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
298386001667	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
298386001668	Walker A/P-loop; other site
298386001669	ATP binding site [chemical binding]; other site
298386001670	Q-loop/lid; other site
298386001671	ABC transporter signature motif; other site
298386001672	Walker B; other site
298386001673	D-loop; other site
298386001674	H-loop/switch region; other site
298386001675	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
298386001676	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
298386001677	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
298386001678	Walker A/P-loop; other site
298386001679	ATP binding site [chemical binding]; other site
298386001680	Q-loop/lid; other site
298386001681	ABC transporter signature motif; other site
298386001682	Walker B; other site
298386001683	D-loop; other site
298386001684	H-loop/switch region; other site
298386001685	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
298386001686	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
298386001687	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386001688	dimer interface [polypeptide binding]; other site
298386001689	conserved gate region; other site
298386001690	putative PBP binding loops; other site
298386001691	ABC-ATPase subunit interface; other site
298386001692	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
298386001693	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386001694	dimer interface [polypeptide binding]; other site
298386001695	conserved gate region; other site
298386001696	putative PBP binding loops; other site
298386001697	ABC-ATPase subunit interface; other site
298386001698	The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509
298386001699	substrate binding site [chemical binding]; other site
298386001700	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
298386001701	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298386001702	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298386001703	dimerization interface [polypeptide binding]; other site
298386001704	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298386001705	dimer interface [polypeptide binding]; other site
298386001706	phosphorylation site [posttranslational modification]
298386001707	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386001708	ATP binding site [chemical binding]; other site
298386001709	Mg2+ binding site [ion binding]; other site
298386001710	G-X-G motif; other site
298386001711	Response regulator receiver domain; Region: Response_reg; pfam00072
298386001712	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386001713	active site
298386001714	phosphorylation site [posttranslational modification]
298386001715	intermolecular recognition site; other site
298386001716	dimerization interface [polypeptide binding]; other site
298386001717	PAS domain; Region: PAS; smart00091
298386001718	PAS domain; Region: PAS_9; pfam13426
298386001719	16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489
298386001720	Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468
298386001721	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298386001722	S-adenosylmethionine binding site [chemical binding]; other site
298386001723	Domain of unknown function DUF20; Region: UPF0118; pfam01594
298386001724	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
298386001725	glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062
298386001726	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
298386001727	inhibitor-cofactor binding pocket; inhibition site
298386001728	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298386001729	catalytic residue [active]
298386001730	Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038
298386001731	ClC chloride channel EriC.  This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031
298386001732	Cl- selectivity filter; other site
298386001733	Cl- binding residues [ion binding]; other site
298386001734	pore gating glutamate residue; other site
298386001735	dimer interface [polypeptide binding]; other site
298386001736	H+/Cl- coupling transport residue; other site
298386001737	iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623
298386001738	Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525
298386001739	putative peptidase; Provisional; Region: PRK11649
298386001740	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
298386001741	Peptidase family M23; Region: Peptidase_M23; pfam01551
298386001742	tyrosyl-tRNA synthetase; Validated; Region: PRK05912
298386001743	catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805
298386001744	active site
298386001745	HIGH motif; other site
298386001746	dimer interface [polypeptide binding]; other site
298386001747	KMSKS motif; other site
298386001748	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
298386001749	RNA binding surface [nucleotide binding]; other site
298386001750	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
298386001751	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
298386001752	hypothetical protein; Provisional; Region: PRK10578
298386001753	UPF0126 domain; Region: UPF0126; pfam03458
298386001754	UPF0126 domain; Region: UPF0126; pfam03458
298386001755	vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379
298386001756	Cobalamin binding protein BtuF.  These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species.  They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144
298386001757	cobalamin binding residues [chemical binding]; other site
298386001758	putative BtuC binding residues; other site
298386001759	dimer interface [polypeptide binding]; other site
298386001760	adenosylcobinamide-phosphate synthase; Provisional; Region: PRK08878
298386001761	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584
298386001762	5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704
298386001763	glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318
298386001764	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
298386001765	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
298386001766	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
298386001767	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
298386001768	active site
298386001769	dimer interface [polypeptide binding]; other site
298386001770	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
298386001771	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
298386001772	active site
298386001773	FMN binding site [chemical binding]; other site
298386001774	substrate binding site [chemical binding]; other site
298386001775	3Fe-4S cluster binding site [ion binding]; other site
298386001776	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
298386001777	domain interface; other site
298386001778	glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810
298386001779	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
298386001780	glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750
298386001781	Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713
298386001782	active site
298386001783	dimer interface [polypeptide binding]; other site
298386001784	Glutamate synthase central domain; Region: Glu_syn_central; pfam04898
298386001785	Glutamate synthase (GltS) FMN-binding domain.  GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808
298386001786	active site
298386001787	FMN binding site [chemical binding]; other site
298386001788	substrate binding site [chemical binding]; other site
298386001789	3Fe-4S cluster binding site [ion binding]; other site
298386001790	gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982
298386001791	domain interface; other site
298386001792	radical SAM protein, TIGR01212 family; Region: TIGR01212
298386001793	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
298386001794	FeS/SAM binding site; other site
298386001795	PAS fold; Region: PAS_4; pfam08448
298386001796	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
298386001797	putative active site [active]
298386001798	heme pocket [chemical binding]; other site
298386001799	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298386001800	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298386001801	metal binding site [ion binding]; metal-binding site
298386001802	active site
298386001803	I-site; other site
298386001804	aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091
298386001805	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
298386001806	putative active site [active]
298386001807	heme pocket [chemical binding]; other site
298386001808	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298386001809	dimer interface [polypeptide binding]; other site
298386001810	phosphorylation site [posttranslational modification]
298386001811	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386001812	ATP binding site [chemical binding]; other site
298386001813	Mg2+ binding site [ion binding]; other site
298386001814	G-X-G motif; other site
298386001815	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386001816	active site
298386001817	phosphorylation site [posttranslational modification]
298386001818	intermolecular recognition site; other site
298386001819	dimerization interface [polypeptide binding]; other site
298386001820	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
298386001821	putative binding surface; other site
298386001822	active site
298386001823	two-component response regulator; Provisional; Region: PRK11173
298386001824	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386001825	active site
298386001826	phosphorylation site [posttranslational modification]
298386001827	intermolecular recognition site; other site
298386001828	dimerization interface [polypeptide binding]; other site
298386001829	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298386001830	DNA binding site [nucleotide binding]
298386001831	Protein of unknown function (DUF3293); Region: DUF3293; pfam11697
298386001832	ribonuclease activity regulator protein RraA; Reviewed; Region: PRK12487
298386001833	Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579
298386001834	Isocitrate dehydrogenase kinase/phosphatase (AceK); Region: AceK; pfam06315
298386001835	bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436
298386001836	AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257
298386001837	putative catalytic residues [active]
298386001838	putative nucleotide binding site [chemical binding]; other site
298386001839	putative aspartate binding site [chemical binding]; other site
298386001840	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921
298386001841	dimer interface [polypeptide binding]; other site
298386001842	putative threonine allosteric regulatory site; other site
298386001843	ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922
298386001844	putative threonine allosteric regulatory site; other site
298386001845	Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447
298386001846	Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742
298386001847	homoserine kinase; Provisional; Region: PRK01212
298386001848	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
298386001849	threonine synthase; Validated; Region: PRK09225
298386001850	Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498
298386001851	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
298386001852	catalytic residue [active]
298386001853	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
298386001854	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
298386001855	autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127
298386001856	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
298386001857	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
298386001858	DNA interaction; other site
298386001859	Metal-binding active site; metal-binding site
298386001860	AP (apurinic/apyrimidinic) site pocket; other site
298386001861	Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027
298386001862	ligand binding site [chemical binding]; other site
298386001863	active site
298386001864	UGI interface [polypeptide binding]; other site
298386001865	catalytic site [active]
298386001866	Hemerythrin-like domain; Region: Hr-like; cd12108
298386001867	Fe binding site [ion binding]; other site
298386001868	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
298386001869	Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235
298386001870	hypothetical protein; Validated; Region: PRK02101
298386001871	helicase 45; Provisional; Region: PTZ00424
298386001872	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
298386001873	ATP binding site [chemical binding]; other site
298386001874	Mg++ binding site [ion binding]; other site
298386001875	motif III; other site
298386001876	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
298386001877	nucleotide binding region [chemical binding]; other site
298386001878	ATP-binding site [chemical binding]; other site
298386001879	Predicted O-methyltransferase [General function prediction only]; Region: COG4123
298386001880	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298386001881	S-adenosylmethionine binding site [chemical binding]; other site
298386001882	Branched-chain amino acid transport protein; Region: Branch_AA_trans; pfam05525
298386001883	flavodoxin FldB; Provisional; Region: PRK12359
298386001884	site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283
298386001885	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
298386001886	active site
298386001887	Int/Topo IB signature motif; other site
298386001888	protein disulfide isomerase II DsbC; Provisional; Region: PRK10877
298386001889	DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020
298386001890	dimerization domain [polypeptide binding]; other site
298386001891	dimer interface [polypeptide binding]; other site
298386001892	catalytic residues [active]
298386001893	ssDNA exonuclease RecJ; Provisional; Region: PRK11070
298386001894	DHH family; Region: DHH; pfam01368
298386001895	DHHA1 domain; Region: DHHA1; pfam02272
298386001896	peptide chain release factor 2; Validated; Region: prfB; PRK00578
298386001897	This domain is found in peptide chain release factors; Region: PCRF; smart00937
298386001898	RF-1 domain; Region: RF-1; pfam00472
298386001899	lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484
298386001900	LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322
298386001901	dimer interface [polypeptide binding]; other site
298386001902	putative anticodon binding site; other site
298386001903	Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775
298386001904	motif 1; other site
298386001905	active site
298386001906	motif 2; other site
298386001907	motif 3; other site
298386001908	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
298386001909	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
298386001910	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
298386001911	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298386001912	Walker A motif; other site
298386001913	ATP binding site [chemical binding]; other site
298386001914	Walker B motif; other site
298386001915	arginine finger; other site
298386001916	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
298386001917	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
298386001918	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
298386001919	active site
298386001920	catalytic tetrad [active]
298386001921	MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex.   MutH...; Region: MutH_Sau3AI; cd00583
298386001922	putative DNA-binding cleft [nucleotide binding]; other site
298386001923	putative DNA clevage site; other site
298386001924	molecular lever; other site
298386001925	Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671
298386001926	putative active site [active]
298386001927	Ap4A binding site [chemical binding]; other site
298386001928	nudix motif; other site
298386001929	putative metal binding site [ion binding]; other site
298386001930	fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061
298386001931	GAF domain; Region: GAF; pfam01590
298386001932	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
298386001933	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
298386001934	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
298386001935	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
298386001936	prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052
298386001937	thymidylate synthase; Reviewed; Region: thyA; PRK01827
298386001938	Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351
298386001939	dimerization interface [polypeptide binding]; other site
298386001940	active site
298386001941	Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283
298386001942	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
298386001943	Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690
298386001944	pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09560
298386001945	transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062
298386001946	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386001947	The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429
298386001948	putative dimerization interface [polypeptide binding]; other site
298386001949	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
298386001950	dimerization interface [polypeptide binding]; other site
298386001951	putative DNA binding site [nucleotide binding]; other site
298386001952	putative Zn2+ binding site [ion binding]; other site
298386001953	30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239
298386001954	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
298386001955	MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123
298386001956	Uncharacterized membrane protein, putative virulence factor [General function prediction only]; Region: MviN; COG0728
298386001957	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
298386001958	bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627
298386001959	FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064
298386001960	active site
298386001961	Riboflavin kinase; Region: Flavokinase; smart00904
298386001962	isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743
298386001963	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
298386001964	active site
298386001965	HIGH motif; other site
298386001966	nucleotide binding site [chemical binding]; other site
298386001967	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
298386001968	catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818
298386001969	active site
298386001970	KMSKS motif; other site
298386001971	Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960
298386001972	tRNA binding surface [nucleotide binding]; other site
298386001973	anticodon binding site; other site
298386001974	Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827
298386001975	lipoprotein signal peptidase; Provisional; Region: PRK14787
298386001976	lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376
298386001977	FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095
298386001978	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
298386001979	4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045
298386001980	4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761
298386001981	dihydrodipicolinate reductase; Provisional; Region: PRK00048
298386001982	Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113
298386001983	Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173
298386001984	carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564
298386001985	Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097
298386001986	Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744
298386001987	catalytic site [active]
298386001988	subunit interface [polypeptide binding]; other site
298386001989	carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294
298386001990	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
298386001991	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
298386001992	Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787
298386001993	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
298386001994	ATP-grasp domain; Region: ATP-grasp_4; cl17255
298386001995	Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424
298386001996	IMP binding site; other site
298386001997	dimer interface [polypeptide binding]; other site
298386001998	interdomain contacts; other site
298386001999	partial ornithine binding site; other site
298386002000	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
298386002001	Divalent cation transporter; Region: MgtE; cl00786
298386002002	D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113
298386002003	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
298386002004	trimer interface [polypeptide binding]; other site
298386002005	eyelet of channel; other site
298386002006	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
298386002007	transcription elongation factor GreA; Reviewed; Region: greA; PRK00226
298386002008	Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449
298386002009	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
298386002010	CRS1 / YhbY (CRM) domain; Region: CRS1_YhbY; cl00663
298386002011	23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293
298386002012	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298386002013	S-adenosylmethionine binding site [chemical binding]; other site
298386002014	ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733
298386002015	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298386002016	Walker A motif; other site
298386002017	ATP binding site [chemical binding]; other site
298386002018	Walker B motif; other site
298386002019	arginine finger; other site
298386002020	Peptidase family M41; Region: Peptidase_M41; pfam01434
298386002021	DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739
298386002022	dihydropteroate synthase; Region: DHPS; TIGR01496
298386002023	substrate binding pocket [chemical binding]; other site
298386002024	dimer interface [polypeptide binding]; other site
298386002025	inhibitor binding site; inhibition site
298386002026	phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887
298386002027	GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802
298386002028	active site
298386002029	substrate binding site [chemical binding]; other site
298386002030	metal binding site [ion binding]; metal-binding site
298386002031	preprotein translocase subunit SecG; Reviewed; Region: secG; PRK06870
298386002032	ribosome maturation protein RimP; Reviewed; Region: PRK00092
298386002033	Sm and related proteins; Region: Sm_like; cl00259
298386002034	Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734
298386002035	putative oligomer interface [polypeptide binding]; other site
298386002036	putative RNA binding site [nucleotide binding]; other site
298386002037	transcription elongation factor NusA; Validated; Region: nusA; PRK09202
298386002038	NusA N-terminal domain; Region: NusA_N; pfam08529
298386002039	S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455
298386002040	RNA binding site [nucleotide binding]; other site
298386002041	homodimer interface [polypeptide binding]; other site
298386002042	NusA-like KH domain; Region: KH_5; pfam13184
298386002043	NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134
298386002044	G-X-X-G motif; other site
298386002045	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
298386002046	transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954
298386002047	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
298386002048	Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364
298386002049	translation initiation factor IF-2; Region: IF-2; TIGR00487
298386002050	Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760
298386002051	Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887
298386002052	G1 box; other site
298386002053	putative GEF interaction site [polypeptide binding]; other site
298386002054	GTP/Mg2+ binding site [chemical binding]; other site
298386002055	Switch I region; other site
298386002056	G2 box; other site
298386002057	G3 box; other site
298386002058	Switch II region; other site
298386002059	G4 box; other site
298386002060	G5 box; other site
298386002061	This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702
298386002062	Translation-initiation factor 2; Region: IF-2; pfam11987
298386002063	mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692
298386002064	ribosome-binding factor A; Validated; Region: rbfA; PRK00521
298386002065	tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033
298386002066	Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573
298386002067	RNA binding site [nucleotide binding]; other site
298386002068	active site
298386002069	Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157
298386002070	Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353
298386002071	16S/18S rRNA binding site [nucleotide binding]; other site
298386002072	S13e-L30e interaction site [polypeptide binding]; other site
298386002073	25S rRNA binding site [nucleotide binding]; other site
298386002074	polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824
298386002075	Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363
298386002076	RNase E interface [polypeptide binding]; other site
298386002077	trimer interface [polypeptide binding]; other site
298386002078	Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726
298386002079	Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364
298386002080	RNase E interface [polypeptide binding]; other site
298386002081	trimer interface [polypeptide binding]; other site
298386002082	active site
298386002083	Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393
298386002084	putative nucleic acid binding region [nucleotide binding]; other site
298386002085	G-X-X-G motif; other site
298386002086	S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase  is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472
298386002087	RNA binding site [nucleotide binding]; other site
298386002088	domain interface; other site
298386002089	lipoprotein NlpI; Provisional; Region: PRK11189
298386002090	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298386002091	binding surface
298386002092	TPR motif; other site
298386002093	putative protease; Provisional; Region: PRK15447
298386002094	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
298386002095	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
298386002096	Peptidase family U32; Region: Peptidase_U32; pfam01136
298386002097	PAS fold; Region: PAS_4; pfam08448
298386002098	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
298386002099	putative active site [active]
298386002100	heme pocket [chemical binding]; other site
298386002101	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298386002102	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298386002103	metal binding site [ion binding]; metal-binding site
298386002104	active site
298386002105	I-site; other site
298386002106	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
298386002107	Putative lipid carrier protein [Lipid metabolism]; Region: COG3154
298386002108	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298386002109	Coenzyme A binding pocket [chemical binding]; other site
298386002110	DNA polymerase III psi subunit; Region: DNA_III_psi; pfam03603
298386002111	ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491
298386002112	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298386002113	Coenzyme A binding pocket [chemical binding]; other site
298386002114	Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169
298386002115	G1 box; other site
298386002116	putative GEF interaction site [polypeptide binding]; other site
298386002117	GTP/Mg2+ binding site [chemical binding]; other site
298386002118	Switch I region; other site
298386002119	G2 box; other site
298386002120	G3 box; other site
298386002121	Switch II region; other site
298386002122	G4 box; other site
298386002123	G5 box; other site
298386002124	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
298386002125	Translation_Factor_II_like: Elongation factor Tu (EF-Tu) domain II-like proteins. Elongation factor Tu consists of three structural domains, this family represents the second domain. Domain II adopts a beta barrel structure and is involved in binding to...; Region: Translation_Factor_II_like; cl02787
298386002126	Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523
298386002127	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
298386002128	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
298386002129	active site
298386002130	catalytic site [active]
298386002131	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
298386002132	active site
298386002133	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
298386002134	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
298386002135	Nucleoside recognition; Region: Gate; pfam07670
298386002136	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
298386002137	2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959
298386002138	intersubunit interface [polypeptide binding]; other site
298386002139	active site
298386002140	catalytic residue [active]
298386002141	thymidine phosphorylase; Reviewed; Region: deoA; PRK05820
298386002142	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
298386002143	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
298386002144	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941
298386002145	phosphopentomutase; Provisional; Region: PRK05362
298386002146	Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676
298386002147	purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819
298386002148	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
298386002149	Bacterial virulence factor haemolysin; Region: SMP_2; cl11479
298386002150	phosphoserine phosphatase; Provisional; Region: serB; PRK11133
298386002151	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
298386002152	motif II; other site
298386002153	PilZ domain; Region: PilZ; pfam07238
298386002154	PilZ domain; Region: PilZ; pfam07238
298386002155	DNA repair protein RadA; Provisional; Region: PRK11823
298386002156	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
298386002157	Walker A motif; other site
298386002158	ATP binding site [chemical binding]; other site
298386002159	Walker B motif; other site
298386002160	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
298386002161	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
298386002162	Peptidase family M23; Region: Peptidase_M23; pfam01551
298386002163	PilZ domain; Region: PilZ; pfam07238
298386002164	putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819
298386002165	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298386002166	Walker A/P-loop; other site
298386002167	ATP binding site [chemical binding]; other site
298386002168	Q-loop/lid; other site
298386002169	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
298386002170	ABC transporter signature motif; other site
298386002171	Walker B; other site
298386002172	ABC transporter; Region: ABC_tran_2; pfam12848
298386002173	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
298386002174	lytic murein transglycosylase; Provisional; Region: PRK11619
298386002175	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
298386002176	N-acetyl-D-glucosamine binding site [chemical binding]; other site
298386002177	catalytic residue [active]
298386002178	Trp operon repressor; Provisional; Region: PRK01381
298386002179	inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074
298386002180	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
298386002181	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298386002182	non-specific DNA binding site [nucleotide binding]; other site
298386002183	salt bridge; other site
298386002184	sequence-specific DNA binding site [nucleotide binding]; other site
298386002185	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
298386002186	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386002187	active site
298386002188	phosphorylation site [posttranslational modification]
298386002189	intermolecular recognition site; other site
298386002190	dimerization interface [polypeptide binding]; other site
298386002191	LytTr DNA-binding domain; Region: LytTR; smart00850
298386002192	Histidine kinase; Region: His_kinase; pfam06580
298386002193	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386002194	ATP binding site [chemical binding]; other site
298386002195	Mg2+ binding site [ion binding]; other site
298386002196	G-X-G motif; other site
298386002197	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
298386002198	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
298386002199	FtsX-like permease family; Region: FtsX; pfam02687
298386002200	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
298386002201	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
298386002202	Walker A/P-loop; other site
298386002203	ATP binding site [chemical binding]; other site
298386002204	Q-loop/lid; other site
298386002205	ABC transporter signature motif; other site
298386002206	Walker B; other site
298386002207	D-loop; other site
298386002208	H-loop/switch region; other site
298386002209	Domain of unknown function (DUF4382); Region: DUF4382; pfam14321
298386002210	ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575
298386002211	Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739
298386002212	Peptidase family M23; Region: Peptidase_M23; pfam01551
298386002213	Integral membrane protein CcmA involved in cell shape determination [Cell envelope biogenesis, outer membrane]; Region: CcmA; COG1664
298386002214	Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519
298386002215	Cupin superfamily (DUF985); Region: Cupin_5; pfam06172
298386002216	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
298386002217	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298386002218	active site
298386002219	ATP binding site [chemical binding]; other site
298386002220	substrate binding site [chemical binding]; other site
298386002221	activation loop (A-loop); other site
298386002222	type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354
298386002223	Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060
298386002224	phosphopeptide binding site; other site
298386002225	type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352
298386002226	type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353
298386002227	Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936
298386002228	Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850
298386002229	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
298386002230	ligand binding site [chemical binding]; other site
298386002231	type VI secretion protein IcmF; Region: VI_IcmF; TIGR03348
298386002232	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
298386002233	G1 box; other site
298386002234	GTP/Mg2+ binding site [chemical binding]; other site
298386002235	G2 box; other site
298386002236	Switch I region; other site
298386002237	G3 box; other site
298386002238	Switch II region; other site
298386002239	G4 box; other site
298386002240	Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761
298386002241	Protein of unknown function (DUF1215); Region: DUF1215; pfam06744
298386002242	type VI secretion-associated protein, BMA_A0400 family; Region: VI_minor_4; TIGR03373
298386002243	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
298386002244	Protein phosphatase 2C; Region: PP2C; pfam00481
298386002245	active site
298386002246	type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363
298386002247	ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812
298386002248	Protein of unknown function (DUF770); Region: DUF770; pfam05591
298386002249	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
298386002250	Protein of unknown function (DUF877); Region: DUF877; pfam05943
298386002251	Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3517; cl05484
298386002252	Protein of unknown function (DUF877); Region: DUF877; pfam05943
298386002253	Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455
298386002254	ImpE protein; Region: ImpE; pfam07024
298386002255	type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357
298386002256	Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and    vesicular transport]; Region: COG3519
298386002257	type VI secretion protein, VC_A0110 family; Region: VI_chp_6; TIGR03359
298386002258	type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347
298386002259	type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345
298386002260	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298386002261	Walker A motif; other site
298386002262	ATP binding site [chemical binding]; other site
298386002263	Walker B motif; other site
298386002264	arginine finger; other site
298386002265	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298386002266	Walker A motif; other site
298386002267	ATP binding site [chemical binding]; other site
298386002268	Walker B motif; other site
298386002269	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
298386002270	Protein of unknown function (DUF796); Region: DUF796; pfam05638
298386002271	type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361
298386002272	Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954
298386002273	Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717
298386002274	Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733
298386002275	PAAR motif; Region: PAAR_motif; pfam05488
298386002276	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
298386002277	RHS Repeat; Region: RHS_repeat; cl11982
298386002278	RHS Repeat; Region: RHS_repeat; cl11982
298386002279	RHS protein; Region: RHS; pfam03527
298386002280	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
298386002281	Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209
298386002282	RHS protein; Region: RHS; pfam03527
298386002283	RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696
298386002284	Response regulator receiver domain; Region: Response_reg; pfam00072
298386002285	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386002286	active site
298386002287	phosphorylation site [posttranslational modification]
298386002288	intermolecular recognition site; other site
298386002289	dimerization interface [polypeptide binding]; other site
298386002290	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
298386002291	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298386002292	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298386002293	dimer interface [polypeptide binding]; other site
298386002294	phosphorylation site [posttranslational modification]
298386002295	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386002296	ATP binding site [chemical binding]; other site
298386002297	Mg2+ binding site [ion binding]; other site
298386002298	G-X-G motif; other site
298386002299	Response regulator receiver domain; Region: Response_reg; pfam00072
298386002300	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386002301	active site
298386002302	phosphorylation site [posttranslational modification]
298386002303	intermolecular recognition site; other site
298386002304	dimerization interface [polypeptide binding]; other site
298386002305	Methyltransferase domain; Region: Methyltransf_23; pfam13489
298386002306	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298386002307	S-adenosylmethionine binding site [chemical binding]; other site
298386002308	HNH endonuclease; Region: HNH_4; pfam13395
298386002309	Part of AAA domain; Region: AAA_19; pfam13245
298386002310	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386002311	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
298386002312	AAA domain; Region: AAA_12; pfam13087
298386002313	Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294
298386002314	SmpB-tmRNA interface; other site
298386002315	Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813
298386002316	putative coenzyme Q binding site [chemical binding]; other site
298386002317	hypothetical protein; Validated; Region: PRK01777
298386002318	SmpA / OmlA family; Region: SmpA_OmlA; pfam04355
298386002319	recombination and repair protein; Provisional; Region: PRK10869
298386002320	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
298386002321	Walker A/P-loop; other site
298386002322	ATP binding site [chemical binding]; other site
298386002323	Q-loop/lid; other site
298386002324	ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241
298386002325	Q-loop/lid; other site
298386002326	ABC transporter signature motif; other site
298386002327	Walker B; other site
298386002328	D-loop; other site
298386002329	H-loop/switch region; other site
298386002330	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378
298386002331	inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231
298386002332	GrpE; Region: GrpE; pfam01025
298386002333	GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446
298386002334	dimer interface [polypeptide binding]; other site
298386002335	hsp70 (ATPase domain) interactions [polypeptide binding]; other site
298386002336	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
298386002337	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
298386002338	nucleotide binding site [chemical binding]; other site
298386002339	chaperone protein DnaJ; Provisional; Region: PRK10767
298386002340	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
298386002341	HSP70 interaction site [polypeptide binding]; other site
298386002342	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262
298386002343	substrate binding site [polypeptide binding]; other site
298386002344	Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719
298386002345	Zn binding sites [ion binding]; other site
298386002346	C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747
298386002347	dimer interface [polypeptide binding]; other site
298386002348	Tfp pilus assembly protein PilE [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilE; COG4968
298386002349	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
298386002350	Tfp pilus assembly protein FimT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimT; COG4970
298386002351	Tfp pilus assembly protein PilW [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilW; COG4966
298386002352	Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156
298386002353	DDE superfamily endonuclease; Region: DDE_3; pfam13358
298386002354	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
298386002355	Homeodomain-like domain; Region: HTH_23; pfam13384
298386002356	Winged helix-turn helix; Region: HTH_29; pfam13551
298386002357	Winged helix-turn helix; Region: HTH_33; pfam13592
298386002358	Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390
298386002359	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
298386002360	DNA binding residues [nucleotide binding]
298386002361	Putative sugar-binding domain; Region: Sugar-bind; pfam04198
298386002362	penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429
298386002363	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
298386002364	putative protease; Provisional; Region: PRK15452
298386002365	Peptidase family U32; Region: Peptidase_U32; pfam01136
298386002366	Putative exonuclease, RdgC; Region: RdgC; pfam04381
298386002367	exonuclease subunit SbcD; Provisional; Region: PRK10966
298386002368	Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840
298386002369	active site
298386002370	metal binding site [ion binding]; metal-binding site
298386002371	DNA binding site [nucleotide binding]
298386002372	Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320
298386002373	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298386002374	AAA domain; Region: AAA_23; pfam13476
298386002375	Walker A/P-loop; other site
298386002376	ATP binding site [chemical binding]; other site
298386002377	Q-loop/lid; other site
298386002378	ABC transporter signature motif; other site
298386002379	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298386002380	ABC transporter signature motif; other site
298386002381	Walker B; other site
298386002382	D-loop; other site
298386002383	H-loop/switch region; other site
298386002384	phosphate regulon transcriptional regulatory protein PhoB; Region: PhoB; TIGR02154
298386002385	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386002386	active site
298386002387	phosphorylation site [posttranslational modification]
298386002388	intermolecular recognition site; other site
298386002389	dimerization interface [polypeptide binding]; other site
298386002390	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298386002391	DNA binding site [nucleotide binding]
298386002392	phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006
298386002393	Domain of unknown function (DUF3329); Region: DUF3329; pfam11808
298386002394	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
298386002395	putative active site [active]
298386002396	heme pocket [chemical binding]; other site
298386002397	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298386002398	dimer interface [polypeptide binding]; other site
298386002399	phosphorylation site [posttranslational modification]
298386002400	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386002401	ATP binding site [chemical binding]; other site
298386002402	Mg2+ binding site [ion binding]; other site
298386002403	G-X-G motif; other site
298386002404	PBP superfamily domain; Region: PBP_like_2; cl17296
298386002405	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
298386002406	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
298386002407	Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089
298386002408	polyphosphate kinase 1; Region: poly_P_kin; TIGR03705
298386002409	Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503
298386002410	Catalytic C-terminal domain, first repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C1_like; cd09164
298386002411	domain interface [polypeptide binding]; other site
298386002412	active site
298386002413	catalytic site [active]
298386002414	Catalytic C-terminal domain, second repeat, of Escherichia coli polyphosphate kinase 1 and similar proteins; Region: PLDc_EcPPK1_C2_like; cd09167
298386002415	domain interface [polypeptide binding]; other site
298386002416	active site
298386002417	catalytic site [active]
298386002418	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
298386002419	ACT domain; Region: ACT_6; pfam13740
298386002420	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869
298386002421	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4590
298386002422	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386002423	conserved gate region; other site
298386002424	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386002425	putative PBP binding loops; other site
298386002426	dimer interface [polypeptide binding]; other site
298386002427	ABC-ATPase subunit interface; other site
298386002428	ABC-type phosphate transport system, auxiliary component [Inorganic ion transport and metabolism]; Region: COG4985
298386002429	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
298386002430	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386002431	dimer interface [polypeptide binding]; other site
298386002432	conserved gate region; other site
298386002433	putative PBP binding loops; other site
298386002434	ABC-ATPase subunit interface; other site
298386002435	phosphate transporter ATP-binding protein; Provisional; Region: PRK14236
298386002436	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
298386002437	Walker A/P-loop; other site
298386002438	ATP binding site [chemical binding]; other site
298386002439	Q-loop/lid; other site
298386002440	ABC transporter signature motif; other site
298386002441	Walker B; other site
298386002442	D-loop; other site
298386002443	H-loop/switch region; other site
298386002444	transcriptional regulator PhoU; Provisional; Region: PRK11115
298386002445	PhoU domain; Region: PhoU; pfam01895
298386002446	PhoU domain; Region: PhoU; pfam01895
298386002447	polyphosphate kinase 2, PA0141 family; Region: PPK2_P_aer; TIGR03707
298386002448	TAP-like protein; Region: Abhydrolase_4; pfam08386
298386002449	Uncharacterized protein involved in copper resistance [Inorganic ion transport and metabolism]; Region: CutC; COG3142
298386002450	peroxidase; Provisional; Region: PRK15000
298386002451	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
298386002452	dimer interface [polypeptide binding]; other site
298386002453	decamer (pentamer of dimers) interface [polypeptide binding]; other site
298386002454	catalytic triad [active]
298386002455	peroxidatic and resolving cysteines [active]
298386002456	DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151
298386002457	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386002458	The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411
298386002459	dimerization interface [polypeptide binding]; other site
298386002460	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
298386002461	malate synthase A; Region: malate_syn_A; TIGR01344
298386002462	active site
298386002463	isocitrate lyase; Provisional; Region: PRK15063
298386002464	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
298386002465	tetramer interface [polypeptide binding]; other site
298386002466	active site
298386002467	Mg2+/Mn2+ binding site [ion binding]; other site
298386002468	Protein of unknown function, DUF479; Region: DUF479; cl01203
298386002469	FOG: CBS domain [General function prediction only]; Region: COG0517
298386002470	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
298386002471	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190
298386002472	cleavage site
298386002473	active site
298386002474	substrate binding sites [chemical binding]; other site
298386002475	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147
298386002476	S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113
298386002477	queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112
298386002478	Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343
298386002479	preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585
298386002480	SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721
298386002481	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812
298386002482	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
298386002483	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
298386002484	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022
298386002485	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
298386002486	Protein export membrane protein; Region: SecD_SecF; pfam02355
298386002487	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
298386002488	IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639
298386002489	active site
298386002490	dimerization interface [polypeptide binding]; other site
298386002491	tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114
298386002492	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
298386002493	Transcriptional regulator; Region: Rrf2; cl17282
298386002494	Rrf2 family protein; Region: rrf2_super; TIGR00738
298386002495	cysteine desulfurase; Provisional; Region: PRK14012
298386002496	cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402
298386002497	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
298386002498	catalytic residue [active]
298386002499	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
298386002500	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664
298386002501	trimerization site [polypeptide binding]; other site
298386002502	active site
298386002503	iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502
298386002504	co-chaperone HscB; Provisional; Region: hscB; PRK05014
298386002505	DnaJ domain; Region: DnaJ; pfam00226
298386002506	HSP70 interaction site [polypeptide binding]; other site
298386002507	HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743
298386002508	chaperone protein HscA; Provisional; Region: hscA; PRK05183
298386002509	Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236
298386002510	nucleotide binding site [chemical binding]; other site
298386002511	putative NEF/HSP70 interaction site [polypeptide binding]; other site
298386002512	SBD interface [polypeptide binding]; other site
298386002513	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
298386002514	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
298386002515	catalytic loop [active]
298386002516	iron binding site [ion binding]; other site
298386002517	FeS assembly protein IscX; Region: iscX_yfhJ; TIGR03412
298386002518	aminopeptidase B; Provisional; Region: PRK05015
298386002519	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
298386002520	interface (dimer of trimers) [polypeptide binding]; other site
298386002521	Substrate-binding/catalytic site; other site
298386002522	Zn-binding sites [ion binding]; other site
298386002523	aminopeptidase B; Provisional; Region: PRK05015
298386002524	Peptidase; Region: DUF3663; pfam12404
298386002525	Cytosol aminopeptidase family, N-terminal and catalytic domains.  Family M17 contains zinc- and manganese-dependent exopeptidases ( EC  3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433
298386002526	interface (dimer of trimers) [polypeptide binding]; other site
298386002527	Substrate-binding/catalytic site; other site
298386002528	Zn-binding sites [ion binding]; other site
298386002529	Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413
298386002530	active site
298386002531	multimer interface [polypeptide binding]; other site
298386002532	ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194
298386002533	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
298386002534	FeS/SAM binding site; other site
298386002535	Tfp pilus assembly protein PilF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilF; COG3063
298386002536	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298386002537	binding surface
298386002538	TPR motif; other site
298386002539	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298386002540	binding surface
298386002541	TPR motif; other site
298386002542	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298386002543	cytoskeletal protein RodZ; Provisional; Region: PRK10856
298386002544	non-specific DNA binding site [nucleotide binding]; other site
298386002545	salt bridge; other site
298386002546	sequence-specific DNA binding site [nucleotide binding]; other site
298386002547	Domain of unknown function (DUF4115); Region: DUF4115; pfam13464
298386002548	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366
298386002549	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
298386002550	4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694
298386002551	histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037
298386002552	Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773
298386002553	dimer interface [polypeptide binding]; other site
298386002554	motif 1; other site
298386002555	active site
298386002556	motif 2; other site
298386002557	motif 3; other site
298386002558	HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859
298386002559	anticodon binding site; other site
298386002560	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976
298386002561	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
298386002562	binding surface
298386002563	TPR motif; other site
298386002564	outer membrane biogenesis protein BamB; Provisional; Region: PRK11138
298386002565	Beta-barrel assembly machinery (Bam) complex component B and related proteins; Region: BamB_YfgL; cd10276
298386002566	Trp docking motif [polypeptide binding]; other site
298386002567	GTP-binding protein Der; Reviewed; Region: PRK00093
298386002568	EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894
298386002569	G1 box; other site
298386002570	GTP/Mg2+ binding site [chemical binding]; other site
298386002571	Switch I region; other site
298386002572	G2 box; other site
298386002573	Switch II region; other site
298386002574	G3 box; other site
298386002575	G4 box; other site
298386002576	G5 box; other site
298386002577	EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895
298386002578	G1 box; other site
298386002579	GTP/Mg2+ binding site [chemical binding]; other site
298386002580	Switch I region; other site
298386002581	G2 box; other site
298386002582	G3 box; other site
298386002583	Switch II region; other site
298386002584	G4 box; other site
298386002585	G5 box; other site
298386002586	Predicted metal-dependent hydrolases related to alanyl-tRNA synthetase HxxxH domain [General function prediction only]; Region: COG2872
298386002587	Transcriptional regulators [Transcription]; Region: PurR; COG1609
298386002588	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298386002589	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
298386002590	dimer interface [polypeptide binding]; other site
298386002591	putative CheW interface [polypeptide binding]; other site
298386002592	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
298386002593	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386002594	active site
298386002595	phosphorylation site [posttranslational modification]
298386002596	intermolecular recognition site; other site
298386002597	dimerization interface [polypeptide binding]; other site
298386002598	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
298386002599	anti sigma factor interaction site; other site
298386002600	regulatory phosphorylation site [posttranslational modification]; other site
298386002601	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
298386002602	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
298386002603	putative binding surface; other site
298386002604	active site
298386002605	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
298386002606	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386002607	ATP binding site [chemical binding]; other site
298386002608	Mg2+ binding site [ion binding]; other site
298386002609	G-X-G motif; other site
298386002610	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256
298386002611	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298386002612	dimerization interface [polypeptide binding]; other site
298386002613	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
298386002614	dimer interface [polypeptide binding]; other site
298386002615	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
298386002616	putative CheW interface [polypeptide binding]; other site
298386002617	CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705
298386002618	Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352
298386002619	CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739
298386002620	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
298386002621	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386002622	active site
298386002623	phosphorylation site [posttranslational modification]
298386002624	intermolecular recognition site; other site
298386002625	dimerization interface [polypeptide binding]; other site
298386002626	CheB methylesterase; Region: CheB_methylest; pfam01339
298386002627	exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286
298386002628	ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489
298386002629	generic binding surface II; other site
298386002630	generic binding surface I; other site
298386002631	inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567
298386002632	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
298386002633	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein.  IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601
298386002634	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
298386002635	active site
298386002636	GMP synthase; Reviewed; Region: guaA; PRK00074
298386002637	Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742
298386002638	AMP/PPi binding site [chemical binding]; other site
298386002639	candidate oxyanion hole; other site
298386002640	catalytic triad [active]
298386002641	potential glutamine specificity residues [chemical binding]; other site
298386002642	The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997
298386002643	ATP Binding subdomain [chemical binding]; other site
298386002644	Ligand Binding sites [chemical binding]; other site
298386002645	Dimerization subdomain; other site
298386002646	p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819
298386002647	AbgT putative transporter family; Region: ABG_transport; pfam03806
298386002648	S-formylglutathione hydrolase; Region: PLN02442
298386002649	S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821
298386002650	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
298386002651	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
298386002652	substrate binding site [chemical binding]; other site
298386002653	catalytic Zn binding site [ion binding]; other site
298386002654	NAD binding site [chemical binding]; other site
298386002655	structural Zn binding site [ion binding]; other site
298386002656	dimer interface [polypeptide binding]; other site
298386002657	Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285
298386002658	nucleoside/Zn binding site; other site
298386002659	dimer interface [polypeptide binding]; other site
298386002660	catalytic motif [active]
298386002661	membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859
298386002662	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
298386002663	substrate binding pocket [chemical binding]; other site
298386002664	membrane-bound complex binding site; other site
298386002665	hinge residues; other site
298386002666	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
298386002667	N-acetyl-D-glucosamine binding site [chemical binding]; other site
298386002668	catalytic residue [active]
298386002669	phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297
298386002670	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203
298386002671	dimerization interface [polypeptide binding]; other site
298386002672	ATP binding site [chemical binding]; other site
298386002673	PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204
298386002674	dimerization interface [polypeptide binding]; other site
298386002675	ATP binding site [chemical binding]; other site
298386002676	Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740
298386002677	putative active site [active]
298386002678	catalytic triad [active]
298386002679	Transposase IS200 like; Region: Y1_Tnp; pfam01797
298386002680	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
298386002681	Transposase; Region: DEDD_Tnp_IS110; pfam01548
298386002682	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
298386002683	Nitrogen regulatory protein P-II; Region: P-II; smart00938
298386002684	Uncharacterized conserved protein [Function unknown]; Region: COG1284
298386002685	serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011
298386002686	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
298386002687	dimer interface [polypeptide binding]; other site
298386002688	active site
298386002689	glycine-pyridoxal phosphate binding site [chemical binding]; other site
298386002690	folate binding site [chemical binding]; other site
298386002691	transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464
298386002692	ATP cone domain; Region: ATP-cone; pfam03477
298386002693	bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786
298386002694	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
298386002695	catalytic motif [active]
298386002696	Zn binding site [ion binding]; other site
298386002697	RibD C-terminal domain; Region: RibD_C; cl17279
298386002698	riboflavin synthase subunit alpha; Provisional; Region: PRK09289
298386002699	Lumazine binding domain; Region: Lum_binding; pfam00677
298386002700	Lumazine binding domain; Region: Lum_binding; pfam00677
298386002701	bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II-like protein; Provisional; Region: PRK14019
298386002702	3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926
298386002703	GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925
298386002704	dimerization interface [polypeptide binding]; other site
298386002705	active site
298386002706	lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209
298386002707	homopentamer interface [polypeptide binding]; other site
298386002708	active site
298386002709	transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202
298386002710	putative RNA binding site [nucleotide binding]; other site
298386002711	thiamine monophosphate kinase; Provisional; Region: PRK05731
298386002712	ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194
298386002713	ATP binding site [chemical binding]; other site
298386002714	dimerization interface [polypeptide binding]; other site
298386002715	Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971
298386002716	tetramer interfaces [polypeptide binding]; other site
298386002717	binuclear metal-binding site [ion binding]; other site
298386002718	1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444
298386002719	Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007
298386002720	TPP-binding site; other site
298386002721	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
298386002722	PYR/PP interface [polypeptide binding]; other site
298386002723	dimer interface [polypeptide binding]; other site
298386002724	TPP binding site [chemical binding]; other site
298386002725	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
298386002726	Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142
298386002727	Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685
298386002728	substrate binding pocket [chemical binding]; other site
298386002729	chain length determination region; other site
298386002730	substrate-Mg2+ binding site; other site
298386002731	catalytic residues [active]
298386002732	aspartate-rich region 1; other site
298386002733	active site lid residues [active]
298386002734	aspartate-rich region 2; other site
298386002735	exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977
298386002736	flagellar motor protein PomA; Reviewed; Region: PRK08990
298386002737	Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291
298386002738	flagellar motor protein MotB; Reviewed; Region: motB; PRK08944
298386002739	Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677
298386002740	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
298386002741	ligand binding site [chemical binding]; other site
298386002742	tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269
298386002743	THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716
298386002744	ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712
298386002745	Ligand Binding Site [chemical binding]; other site
298386002746	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
298386002747	active site residue [active]
298386002748	oxidative-stress-resistance chaperone; Provisional; Region: PRK11574
298386002749	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
298386002750	conserved cys residue [active]
298386002751	2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522
298386002752	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
298386002753	Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546
298386002754	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502
298386002755	Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502
298386002756	muropeptide transporter; Reviewed; Region: ampG; PRK11902
298386002757	AmpG-like permease; Region: 2A0125; TIGR00901
298386002758	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
298386002759	active site
298386002760	Uncharacterized lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG3056
298386002761	Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923
298386002762	SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001
298386002763	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298386002764	S-adenosylmethionine binding site [chemical binding]; other site
298386002765	BolA-like protein; Region: BolA; cl00386
298386002766	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
298386002767	Na(+)-translocating NADH-quinone reductase subunit A; Provisional; Region: PRK05352
298386002768	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
298386002769	E3 interaction surface; other site
298386002770	lipoyl attachment site [posttranslational modification]; other site
298386002771	NQRA C-terminal domain; Region: NQRA_SLBB; pfam11973
298386002772	Na(+)-translocating NADH-quinone reductase subunit B; Provisional; Region: PRK05349
298386002773	Na(+)-translocating NADH-quinone reductase subunit C; Provisional; Region: PRK05346
298386002774	NADH:ubiquinone oxidoreductase, Na(+)-translocating, C subunit; Region: nqrC; TIGR01938
298386002775	Na(+)-translocating NADH-quinone reductase subunit D; Validated; Region: PRK09292
298386002776	Na(+)-translocating NADH-quinone reductase subunit E; Provisional; Region: PRK02830
298386002777	Na(+)-translocating NADH-quinone reductase subunit F; Provisional; Region: PRK05464
298386002778	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
298386002779	catalytic loop [active]
298386002780	iron binding site [ion binding]; other site
298386002781	Na+-translocating NADH:quinone oxidoreductase (Na+-NQR) FAD/NADH binding domain. (Na+-NQR) provides a means of storing redox reaction energy via the transmembrane translocation of Na2+ ions. The C-terminal domain resembles ferredoxin:NADP+ oxidoreductase; Region: NADH_quinone_reductase; cd06188
298386002782	FAD binding pocket [chemical binding]; other site
298386002783	FAD binding motif [chemical binding]; other site
298386002784	phosphate binding motif [ion binding]; other site
298386002785	beta-alpha-beta structure motif; other site
298386002786	NAD binding pocket [chemical binding]; other site
298386002787	Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477
298386002788	ApbE family; Region: ApbE; pfam02424
298386002789	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991
298386002790	response regulator PleD; Reviewed; Region: pleD; PRK09581
298386002791	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386002792	active site
298386002793	phosphorylation site [posttranslational modification]
298386002794	intermolecular recognition site; other site
298386002795	dimerization interface [polypeptide binding]; other site
298386002796	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386002797	active site
298386002798	phosphorylation site [posttranslational modification]
298386002799	intermolecular recognition site; other site
298386002800	dimerization interface [polypeptide binding]; other site
298386002801	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298386002802	metal binding site [ion binding]; metal-binding site
298386002803	active site
298386002804	I-site; other site
298386002805	DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586
298386002806	active site
298386002807	DNA polymerase IV; Validated; Region: PRK02406
298386002808	DNA binding site [nucleotide binding]
298386002809	Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893
298386002810	M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890
298386002811	metal binding site [ion binding]; metal-binding site
298386002812	dimer interface [polypeptide binding]; other site
298386002813	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
298386002814	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
298386002815	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
298386002816	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
298386002817	active site
298386002818	fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077
298386002819	Transcriptional regulator Crl; Region: Crl; pfam07417
298386002820	gamma-glutamyl kinase; Provisional; Region: PRK05429
298386002821	AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242
298386002822	nucleotide binding site [chemical binding]; other site
298386002823	homotetrameric interface [polypeptide binding]; other site
298386002824	putative phosphate binding site [ion binding]; other site
298386002825	putative allosteric binding site; other site
298386002826	PUA domain; Region: PUA; pfam01472
298386002827	Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079
298386002828	gamma-glutamyl phosphate reductase; Region: proA; TIGR00407
298386002829	putative catalytic cysteine [active]
298386002830	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
298386002831	D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557
298386002832	succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009
298386002833	M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891
298386002834	metal binding site [ion binding]; metal-binding site
298386002835	dimer interface [polypeptide binding]; other site
298386002836	Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035
298386002837	ArsC family; Region: ArsC; pfam03960
298386002838	putative catalytic residues [active]
298386002839	Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; cl11547
298386002840	Domain of unknown function (DUF4156); Region: DUF4156; pfam13698
298386002841	transcriptional regulator NarP; Provisional; Region: PRK10403
298386002842	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386002843	active site
298386002844	phosphorylation site [posttranslational modification]
298386002845	intermolecular recognition site; other site
298386002846	dimerization interface [polypeptide binding]; other site
298386002847	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298386002848	DNA binding residues [nucleotide binding]
298386002849	dimerization interface [polypeptide binding]; other site
298386002850	nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935
298386002851	Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675
298386002852	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298386002853	dimerization interface [polypeptide binding]; other site
298386002854	Histidine kinase; Region: HisKA_3; pfam07730
298386002855	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386002856	ATP binding site [chemical binding]; other site
298386002857	Mg2+ binding site [ion binding]; other site
298386002858	G-X-G motif; other site
298386002859	4Fe-4S dicluster domain; Region: Fer4_10; pfam13237
298386002860	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
298386002861	NapD protein; Region: NapD; pfam03927
298386002862	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
298386002863	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
298386002864	[4Fe-4S] binding site [ion binding]; other site
298386002865	molybdopterin cofactor binding site; other site
298386002866	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
298386002867	molybdopterin cofactor binding site; other site
298386002868	Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892
298386002869	Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005
298386002870	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
298386002871	Protein of unknown function (DUF1499); Region: DUF1499; pfam07386
298386002872	Protein of unknown function (DUF2956); Region: DUF2956; pfam11169
298386002873	Protein of unknown function (DUF2919); Region: DUF2919; pfam11143
298386002874	Dyp-type peroxidase family; Region: Dyp_perox; pfam04261
298386002875	PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210
298386002876	HPr interaction site; other site
298386002877	glycerol kinase (GK) interaction site [polypeptide binding]; other site
298386002878	active site
298386002879	phosphorylation site [posttranslational modification]
298386002880	phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177
298386002881	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
298386002882	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
298386002883	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
298386002884	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
298386002885	dimerization domain swap beta strand [polypeptide binding]; other site
298386002886	regulatory protein interface [polypeptide binding]; other site
298386002887	active site
298386002888	regulatory phosphorylation site [posttranslational modification]; other site
298386002889	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
298386002890	CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561
298386002891	dimer interface [polypeptide binding]; other site
298386002892	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298386002893	catalytic residue [active]
298386002894	putative sulfate transport protein CysZ; Validated; Region: PRK04949
298386002895	Cell division protein [Cell division and chromosome partitioning]; Region: ZipA; COG3115
298386002896	ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038
298386002897	FtsZ protein binding site [polypeptide binding]; other site
298386002898	NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956
298386002899	NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114
298386002900	nucleotide binding pocket [chemical binding]; other site
298386002901	K-X-D-G motif; other site
298386002902	catalytic site [active]
298386002903	NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120
298386002904	NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119
298386002905	Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027
298386002906	Dimer interface [polypeptide binding]; other site
298386002907	BRCT sequence motif; other site
298386002908	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
298386002909	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
298386002910	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
298386002911	Transposase IS200 like; Region: Y1_Tnp; pfam01797
298386002912	Protein of unknown function (DUF2799); Region: DUF2799; pfam10973
298386002913	glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406
298386002914	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
298386002915	active site
298386002916	HIGH motif; other site
298386002917	catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808
298386002918	active site
298386002919	KMSKS motif; other site
298386002920	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
298386002921	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
298386002922	eyelet of channel; other site
298386002923	trimer interface [polypeptide binding]; other site
298386002924	integrase; Provisional; Region: PRK09692
298386002925	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
298386002926	active site
298386002927	DNA binding site [nucleotide binding]
298386002928	Int/Topo IB signature motif; other site
298386002929	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
298386002930	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
298386002931	active site
298386002932	metal binding site [ion binding]; metal-binding site
298386002933	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838
298386002934	Transposase IS200 like; Region: Y1_Tnp; pfam01797
298386002935	Type I restriction-modification system methyltransferase subunit [Defense mechanisms]; Region: HsdM; COG0286
298386002936	HsdM N-terminal domain; Region: HsdM_N; pfam12161
298386002937	Methyltransferase domain; Region: Methyltransf_26; pfam13659
298386002938	Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732
298386002939	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
298386002940	Uncharacterized conserved protein [Function unknown]; Region: COG1479
298386002941	Protein of unknown function DUF262; Region: DUF262; pfam03235
298386002942	Protein of unknown function DUF262; Region: DUF262; pfam03235
298386002943	Uncharacterized conserved protein [Function unknown]; Region: COG1479
298386002944	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
298386002945	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610
298386002946	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313
298386002947	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
298386002948	ATP binding site [chemical binding]; other site
298386002949	putative Mg++ binding site [ion binding]; other site
298386002950	Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961
298386002951	Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768
298386002952	catalytic residues [active]
298386002953	catalytic nucleophile [active]
298386002954	Presynaptic Site I dimer interface [polypeptide binding]; other site
298386002955	Synaptic Antiparallel dimer interface [polypeptide binding]; other site
298386002956	Synaptic Flat tetramer interface [polypeptide binding]; other site
298386002957	Synaptic Site I dimer interface [polypeptide binding]; other site
298386002958	DNA binding site [nucleotide binding]
298386002959	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
298386002960	G1 box; other site
298386002961	GTP/Mg2+ binding site [chemical binding]; other site
298386002962	G2 box; other site
298386002963	G3 box; other site
298386002964	Switch II region; other site
298386002965	G4 box; other site
298386002966	Uncharacterized protein/domain associated with GTPases [Function unknown]; Region: COG3597
298386002967	Predicted integral membrane protein [Function unknown]; Region: COG5616
298386002968	LPP20 lipoprotein; Region: LPP20; cl15824
298386002969	FlgN protein; Region: FlgN; pfam05130
298386002970	Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316
298386002971	flagellar basal body P-ring biosynthesis protein FlgA; Reviewed; Region: flgA; PRK07018
298386002972	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
298386002973	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
298386002974	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
298386002975	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
298386002976	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386002977	active site
298386002978	phosphorylation site [posttranslational modification]
298386002979	intermolecular recognition site; other site
298386002980	dimerization interface [polypeptide binding]; other site
298386002981	Methyltransferase, chemotaxis proteins; Region: MeTrc; smart00138
298386002982	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298386002983	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182
298386002984	flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680
298386002985	flagellar basal body rod protein FlgC; Provisional; Region: flgC; PRK12631
298386002986	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
298386002987	flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655
298386002988	Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963
298386002989	FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861
298386002990	flagellar hook protein FlgE; Validated; Region: flgE; PRK05682
298386002991	Flagellar basal body protein FlaE; Region: FlaE; pfam07559
298386002992	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
298386002993	flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640
298386002994	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
298386002995	flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693
298386002996	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
298386002997	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
298386002998	flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249
298386002999	flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303
298386003000	flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622
298386003001	flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684
298386003002	Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951
298386003003	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; pfam01832
298386003004	flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08871
298386003005	Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460
298386003006	Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429
298386003007	flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08870
298386003008	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
298386003009	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
298386003010	flagellin; Reviewed; Region: PRK08869
298386003011	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
298386003012	Flagellin hook IN motif; Region: Flagellin_IN; pfam07196
298386003013	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
298386003014	flagellin; Reviewed; Region: PRK08869
298386003015	Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669
298386003016	Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700
298386003017	flagellar protein FlaG; Provisional; Region: PRK08868
298386003018	Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345
298386003019	Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465
298386003020	Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195
298386003021	flagellar protein FliS; Validated; Region: fliS; PRK05685
298386003022	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
298386003023	Flagellar regulatory protein FleQ; Region: FleQ; pfam06490
298386003024	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298386003025	Walker A motif; other site
298386003026	ATP binding site [chemical binding]; other site
298386003027	Walker B motif; other site
298386003028	arginine finger; other site
298386003029	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
298386003030	phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966
298386003031	PAS domain; Region: PAS_8; pfam13188
298386003032	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298386003033	dimer interface [polypeptide binding]; other site
298386003034	phosphorylation site [posttranslational modification]
298386003035	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386003036	ATP binding site [chemical binding]; other site
298386003037	Mg2+ binding site [ion binding]; other site
298386003038	G-X-G motif; other site
298386003039	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
298386003040	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386003041	active site
298386003042	phosphorylation site [posttranslational modification]
298386003043	intermolecular recognition site; other site
298386003044	dimerization interface [polypeptide binding]; other site
298386003045	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298386003046	Walker A motif; other site
298386003047	ATP binding site [chemical binding]; other site
298386003048	Walker B motif; other site
298386003049	arginine finger; other site
298386003050	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
298386003051	flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253
298386003052	flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007
298386003053	Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907
298386003054	Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345
298386003055	flagellar motor switch protein G; Validated; Region: fliG; PRK05686
298386003056	MgtE intracellular N domain; Region: MgtE_N; smart00924
298386003057	FliG C-terminal domain; Region: FliG_C; pfam01706
298386003058	flagellar assembly protein H; Validated; Region: fliH; PRK05687
298386003059	Flagellar assembly protein FliH; Region: FliH; pfam02108
298386003060	flagellum-specific ATP synthase; Validated; Region: fliI; PRK08972
298386003061	Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136
298386003062	Walker A motif/ATP binding site; other site
298386003063	Walker B motif; other site
298386003064	flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689
298386003065	Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882
298386003066	Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120
298386003067	flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK05696
298386003068	flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666
298386003069	Surface presentation of antigens (SPOA); Region: SpoA; pfam01052
298386003070	flagellar motor switch protein; Validated; Region: fliN; PRK05698
298386003071	flagellar motor switch protein; Validated; Region: fliN; PRK08983
298386003072	flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699
298386003073	flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700
298386003074	flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701
298386003075	flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702
298386003076	Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257
298386003077	flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012
298386003078	FHIPEP family; Region: FHIPEP; pfam00771
298386003079	flagellar biosynthetic protein FlhF; Region: FlhF; TIGR03499
298386003080	SRP54-type protein, GTPase domain; Region: SRP54; smart00962
298386003081	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
298386003082	CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656
298386003083	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
298386003084	FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038
298386003085	flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986
298386003086	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298386003087	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
298386003088	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
298386003089	DNA binding residues [nucleotide binding]
298386003090	chemotaxis regulatory protein CheY; Provisional; Region: PRK10610
298386003091	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386003092	active site
298386003093	phosphorylation site [posttranslational modification]
298386003094	intermolecular recognition site; other site
298386003095	dimerization interface [polypeptide binding]; other site
298386003096	Chemotaxis phosphatase, CheZ; Region: CheZ; pfam04344
298386003097	Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643
298386003098	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
298386003099	putative binding surface; other site
298386003100	active site
298386003101	Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895
298386003102	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386003103	ATP binding site [chemical binding]; other site
298386003104	Mg2+ binding site [ion binding]; other site
298386003105	G-X-G motif; other site
298386003106	CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731
298386003107	chemotaxis-specific methylesterase; Provisional; Region: PRK00742
298386003108	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386003109	active site
298386003110	phosphorylation site [posttranslational modification]
298386003111	intermolecular recognition site; other site
298386003112	CheB methylesterase; Region: CheB_methylest; pfam01339
298386003113	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
298386003114	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
298386003115	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
298386003116	Magnesium ion binding site [ion binding]; other site
298386003117	CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588
298386003118	CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732
298386003119	putative CheA interaction surface; other site
298386003120	Protein of unknown function (DUF2802); Region: DUF2802; pfam10975
298386003121	cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538
298386003122	Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231
298386003123	Walker A/P-loop; other site
298386003124	ATP binding site [chemical binding]; other site
298386003125	Q-loop/lid; other site
298386003126	ABC transporter signature motif; other site
298386003127	Walker B; other site
298386003128	D-loop; other site
298386003129	H-loop/switch region; other site
298386003130	heme exporter protein CcmB; Region: ccmB; TIGR01190
298386003131	heme exporter protein CcmC; Region: ccmC; TIGR01191
298386003132	cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165
298386003133	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: CcmF; COG1138
298386003134	thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412
298386003135	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
298386003136	catalytic residues [active]
298386003137	central insert; other site
298386003138	Cytochrome C biogenesis protein; Region: CcmH; pfam03918
298386003139	Cytochrome c biogenesis factor [Posttranslational modification, protein turnover, chaperones]; Region: COG4235
298386003140	cytochrome c-type biogenesis protein CcmI; Region: cytochro_ccmI; TIGR03142
298386003141	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298386003142	binding surface
298386003143	TPR motif; other site
298386003144	VacJ like lipoprotein; Region: VacJ; cl01073
298386003145	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; pfam03349
298386003146	Long-chain fatty acid transport protein [Lipid metabolism]; Region: FadL; COG2067
298386003147	Protein of unknown function (DUF3379); Region: DUF3379; pfam11859
298386003148	RNA polymerase sigma factor; Provisional; Region: PRK12517
298386003149	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298386003150	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
298386003151	DNA binding residues [nucleotide binding]
298386003152	3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963
298386003153	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
298386003154	dimer interface [polypeptide binding]; other site
298386003155	active site
298386003156	multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154
298386003157	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298386003158	substrate binding site [chemical binding]; other site
298386003159	oxyanion hole (OAH) forming residues; other site
298386003160	trimer interface [polypeptide binding]; other site
298386003161	3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737
298386003162	3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725
298386003163	Secreted/periplasmic Zn-dependent peptidases, insulinase-like [Posttranslational modification, protein turnover, chaperones]; Region: Ptr; COG1025
298386003164	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
298386003165	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
298386003166	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
298386003167	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
298386003168	catalytic core [active]
298386003169	hypothetical protein; Provisional; Region: PRK04946
298386003170	Smr domain; Region: Smr; pfam01713
298386003171	HemK family putative methylases; Region: hemK_fam; TIGR00536
298386003172	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298386003173	S-adenosylmethionine binding site [chemical binding]; other site
298386003174	ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995
298386003175	Ligand Binding Site [chemical binding]; other site
298386003176	Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031
298386003177	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342
298386003178	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
298386003179	catalytic residue [active]
298386003180	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
298386003181	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
298386003182	putative DNA binding site [nucleotide binding]; other site
298386003183	putative Zn2+ binding site [ion binding]; other site
298386003184	AsnC family; Region: AsnC_trans_reg; pfam01037
298386003185	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
298386003186	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789
298386003187	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298386003188	Walker A/P-loop; other site
298386003189	ATP binding site [chemical binding]; other site
298386003190	Q-loop/lid; other site
298386003191	ABC transporter signature motif; other site
298386003192	Walker B; other site
298386003193	D-loop; other site
298386003194	H-loop/switch region; other site
298386003195	putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790
298386003196	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
298386003197	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298386003198	Walker A/P-loop; other site
298386003199	ATP binding site [chemical binding]; other site
298386003200	Q-loop/lid; other site
298386003201	ABC transporter signature motif; other site
298386003202	Walker B; other site
298386003203	D-loop; other site
298386003204	H-loop/switch region; other site
298386003205	acyl-CoA thioesterase II; Provisional; Region: PRK10526
298386003206	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445
298386003207	active site
298386003208	Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444
298386003209	catalytic triad [active]
298386003210	dimer interface [polypeptide binding]; other site
298386003211	Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825
298386003212	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
298386003213	DNA binding site [nucleotide binding]
298386003214	active site
298386003215	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
298386003216	Integrase core domain; Region: rve; pfam00665
298386003217	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
298386003218	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
298386003219	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
298386003220	Copper resistance protein B precursor (CopB); Region: CopB; pfam05275
298386003221	copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480
298386003222	Multicopper oxidase; Region: Cu-oxidase_3; pfam07732
298386003223	Multicopper oxidase; Region: Cu-oxidase; pfam00394
298386003224	Multicopper oxidase; Region: Cu-oxidase_2; pfam07731
298386003225	Protein of unknown function (DUF3316); Region: DUF3316; pfam11777
298386003226	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
298386003227	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386003228	active site
298386003229	phosphorylation site [posttranslational modification]
298386003230	intermolecular recognition site; other site
298386003231	dimerization interface [polypeptide binding]; other site
298386003232	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298386003233	DNA binding site [nucleotide binding]
298386003234	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
298386003235	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298386003236	dimerization interface [polypeptide binding]; other site
298386003237	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298386003238	dimer interface [polypeptide binding]; other site
298386003239	phosphorylation site [posttranslational modification]
298386003240	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386003241	ATP binding site [chemical binding]; other site
298386003242	Mg2+ binding site [ion binding]; other site
298386003243	G-X-G motif; other site
298386003244	CHASE3 domain; Region: CHASE3; pfam05227
298386003245	CHASE3 domain; Region: CHASE3; pfam05227
298386003246	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
298386003247	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298386003248	dimerization interface [polypeptide binding]; other site
298386003249	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
298386003250	dimer interface [polypeptide binding]; other site
298386003251	putative CheW interface [polypeptide binding]; other site
298386003252	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
298386003253	EamA-like transporter family; Region: EamA; pfam00892
298386003254	EamA-like transporter family; Region: EamA; pfam00892
298386003255	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
298386003256	Na binding site [ion binding]; other site
298386003257	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
298386003258	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298386003259	Amidinotransferase; Region: Amidinotransf; cl12043
298386003260	Bacterial protein of unknown function (DUF885); Region: DUF885; pfam05960
298386003261	Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682
298386003262	Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682
298386003263	Protein of unknown function (DUF3316); Region: DUF3316; pfam11777
298386003264	heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386
298386003265	HAMP domain; Region: HAMP; pfam00672
298386003266	dimerization interface [polypeptide binding]; other site
298386003267	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298386003268	dimer interface [polypeptide binding]; other site
298386003269	phosphorylation site [posttranslational modification]
298386003270	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386003271	ATP binding site [chemical binding]; other site
298386003272	Mg2+ binding site [ion binding]; other site
298386003273	G-X-G motif; other site
298386003274	heavy metal response regulator; Region: cztR_silR_copR; TIGR01387
298386003275	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386003276	active site
298386003277	phosphorylation site [posttranslational modification]
298386003278	intermolecular recognition site; other site
298386003279	dimerization interface [polypeptide binding]; other site
298386003280	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298386003281	DNA binding site [nucleotide binding]
298386003282	Copper resistance protein B precursor (CopB); Region: CopB; cl01476
298386003283	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
298386003284	Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696
298386003285	copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783
298386003286	Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; cl06734
298386003287	HlyD family secretion protein; Region: HlyD_3; pfam13437
298386003288	Copper binding periplasmic protein CusF; Region: CusF_Ec; pfam11604
298386003289	Outer membrane efflux protein; Region: OEP; pfam02321
298386003290	Outer membrane efflux protein; Region: OEP; pfam02321
298386003291	Co/Zn/Cd efflux system component [Inorganic ion transport and metabolism]; Region: CzcD; COG1230
298386003292	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
298386003293	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
298386003294	MarR family; Region: MarR; pfam01047
298386003295	hypothetical protein; Provisional; Region: PRK11038
298386003296	Primosomal replication protein priB and priC; Region: priB_priC; pfam07445
298386003297	ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747
298386003298	DEAD_2; Region: DEAD_2; pfam06733
298386003299	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
298386003300	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
298386003301	Gram-negative porin; Region: Porin_4; pfam13609
298386003302	hypothetical protein; Provisional; Region: PRK03641
298386003303	Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; pfam09829
298386003304	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
298386003305	hypothetical protein; Provisional; Region: PRK10527
298386003306	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
298386003307	active site
298386003308	DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994
298386003309	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298386003310	Walker A motif; other site
298386003311	ATP binding site [chemical binding]; other site
298386003312	Walker B motif; other site
298386003313	DNA polymerase III subunit delta'; Validated; Region: PRK08485
298386003314	arginine finger; other site
298386003315	DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169
298386003316	DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168
298386003317	DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170
298386003318	hypothetical protein; Validated; Region: PRK00153
298386003319	recombination protein RecR; Reviewed; Region: recR; PRK00076
298386003320	RecR protein; Region: RecR; pfam02132
298386003321	TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR.  RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025
298386003322	putative active site [active]
298386003323	putative metal-binding site [ion binding]; other site
298386003324	tetramer interface [polypeptide binding]; other site
298386003325	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
298386003326	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
298386003327	trimer interface [polypeptide binding]; other site
298386003328	eyelet of channel; other site
298386003329	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298386003330	DNA binding site [nucleotide binding]
298386003331	heat shock protein 90; Provisional; Region: PRK05218
298386003332	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386003333	ATP binding site [chemical binding]; other site
298386003334	Mg2+ binding site [ion binding]; other site
298386003335	G-X-G motif; other site
298386003336	adenylate kinase; Reviewed; Region: adk; PRK00279
298386003337	Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428
298386003338	AMP-binding site [chemical binding]; other site
298386003339	ATP-AMP (Ap5A)-binding site [chemical binding]; other site
298386003340	ferrochelatase; Reviewed; Region: hemH; PRK00035
298386003341	Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411
298386003342	active site
298386003343	C-terminal domain interface [polypeptide binding]; other site
298386003344	Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419
298386003345	active site
298386003346	N-terminal domain interface [polypeptide binding]; other site
298386003347	inosine/guanosine kinase; Provisional; Region: PRK15074
298386003348	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
298386003349	substrate binding site [chemical binding]; other site
298386003350	ATP binding site [chemical binding]; other site
298386003351	asparagine synthetase B; Provisional; Region: asnB; PRK09431
298386003352	Glutamine amidotransferases class-II (GATase) asparagine synthase_B type.  Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a  glutaminase domain and a...; Region: AsnB; cd00712
298386003353	active site
298386003354	dimer interface [polypeptide binding]; other site
298386003355	The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B  catalyzes the...; Region: Asn_Synthase_B_C; cd01991
298386003356	Ligand Binding Site [chemical binding]; other site
298386003357	Molecular Tunnel; other site
298386003358	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
298386003359	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
298386003360	Kef-type K+ transport systems, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: Kch; COG1226
298386003361	TrkA-N domain; Region: TrkA_N; pfam02254
298386003362	MarR family; Region: MarR_2; cl17246
298386003363	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
298386003364	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
298386003365	nucleotide binding site [chemical binding]; other site
298386003366	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
298386003367	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
298386003368	active site
298386003369	dimer interface [polypeptide binding]; other site
298386003370	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
298386003371	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
298386003372	active site
298386003373	trimer interface [polypeptide binding]; other site
298386003374	allosteric site; other site
298386003375	active site lid [active]
298386003376	hexamer (dimer of trimers) interface [polypeptide binding]; other site
298386003377	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
298386003378	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
298386003379	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
298386003380	active site turn [active]
298386003381	phosphorylation site [posttranslational modification]
298386003382	Putative carbohydrate binding domain; Region: CHB_HEX; smart01081
298386003383	N-acetyl-beta-hexosaminidase [Carbohydrate transport and metabolism]; Region: Chb; COG3525
298386003384	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
298386003385	The chitobiase of Serratia marcescens is a beta-N-1,4-acetylhexosaminidase with a glycosyl hydrolase family 20 (GH20) domain that hydrolyzes the beta-1,4-glycosidic linkages in oligomers derived from chitin. Chitin is degraded by a two step process: i) a...; Region: GH20_Sm-chitobiase-like; cd06569
298386003386	active site
298386003387	C-terminal Early set domain associated with the catalytic domain of chitobiase (also called N-acetylglucosaminidase); Region: E_set_Chitobiase_C; cd02847
298386003388	glutaminyl-tRNA synthetase; Provisional; Region: PRK05347
298386003389	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
298386003390	active site
298386003391	HIGH motif; other site
298386003392	nucleotide binding site [chemical binding]; other site
298386003393	catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807
298386003394	KMSKS motif; other site
298386003395	tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950
298386003396	ferric uptake regulator; Provisional; Region: fur; PRK09462
298386003397	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
298386003398	metal binding site 2 [ion binding]; metal-binding site
298386003399	putative DNA binding helix; other site
298386003400	metal binding site 1 [ion binding]; metal-binding site
298386003401	dimer interface [polypeptide binding]; other site
298386003402	structural Zn2+ binding site [ion binding]; other site
298386003403	flavodoxin FldA; Validated; Region: PRK09267
298386003404	Protein of unknown function (DUF2788); Region: DUF2788; pfam10981
298386003405	PGAP1-like protein; Region: PGAP1; pfam07819
298386003406	acyl-CoA esterase; Provisional; Region: PRK10673
298386003407	replication initiation regulator SeqA; Provisional; Region: PRK11187
298386003408	phosphoglucomutase; Validated; Region: PRK07564
298386003409	This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801
298386003410	active site
298386003411	substrate binding site [chemical binding]; other site
298386003412	metal binding site [ion binding]; metal-binding site
298386003413	Domain of unknown function (DUF1853); Region: DUF1853; pfam08907
298386003414	Uncharacterized conserved protein [Function unknown]; Region: COG0327
298386003415	NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371
298386003416	Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114
298386003417	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
298386003418	dimer interface [polypeptide binding]; other site
298386003419	active site
298386003420	citrylCoA binding site [chemical binding]; other site
298386003421	NADH binding [chemical binding]; other site
298386003422	cationic pore residues; other site
298386003423	oxalacetate/citrate binding site [chemical binding]; other site
298386003424	coenzyme A binding site [chemical binding]; other site
298386003425	catalytic triad [active]
298386003426	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499
298386003427	Iron-sulfur protein interface; other site
298386003428	proximal quinone binding site [chemical binding]; other site
298386003429	SdhD (CybS) interface [polypeptide binding]; other site
298386003430	proximal heme binding site [chemical binding]; other site
298386003431	Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494
298386003432	cardiolipin binding site; other site
298386003433	SdhC subunit interface [polypeptide binding]; other site
298386003434	proximal heme binding site [chemical binding]; other site
298386003435	Iron-sulfur protein interface; other site
298386003436	proximal quinone binding site [chemical binding]; other site
298386003437	succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958
298386003438	L-aspartate oxidase; Provisional; Region: PRK06175
298386003439	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
298386003440	succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950
298386003441	2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085
298386003442	2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404
298386003443	Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016
298386003444	TPP-binding site [chemical binding]; other site
298386003445	Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779
298386003446	dimer interface [polypeptide binding]; other site
298386003447	PYR/PP interface [polypeptide binding]; other site
298386003448	TPP binding site [chemical binding]; other site
298386003449	dihydrolipoamide succinyltransferase; Validated; Region: PRK05704
298386003450	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
298386003451	E3 interaction surface; other site
298386003452	lipoyl attachment site [posttranslational modification]; other site
298386003453	e3 binding domain; Region: E3_binding; pfam02817
298386003454	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
298386003455	succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696
298386003456	ATP-grasp domain; Region: ATP-grasp_2; pfam08442
298386003457	CoA-ligase; Region: Ligase_CoA; pfam00549
298386003458	succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678
298386003459	CoA binding domain; Region: CoA_binding; pfam02629
298386003460	CoA-ligase; Region: Ligase_CoA; pfam00549
298386003461	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
298386003462	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
298386003463	ABC-ATPase subunit  interface; other site
298386003464	dimer interface [polypeptide binding]; other site
298386003465	putative PBP binding regions; other site
298386003466	high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544
298386003467	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
298386003468	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
298386003469	Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+.  They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019
298386003470	metal binding site [ion binding]; metal-binding site
298386003471	putative peptidase; Provisional; Region: PRK11649
298386003472	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
298386003473	Peptidase family M23; Region: Peptidase_M23; pfam01551
298386003474	FeoA domain; Region: FeoA; pfam04023
298386003475	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
298386003476	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
298386003477	G1 box; other site
298386003478	GTP/Mg2+ binding site [chemical binding]; other site
298386003479	Switch I region; other site
298386003480	G2 box; other site
298386003481	G3 box; other site
298386003482	Switch II region; other site
298386003483	G4 box; other site
298386003484	G5 box; other site
298386003485	Nucleoside recognition; Region: Gate; pfam07670
298386003486	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
298386003487	Nucleoside recognition; Region: Gate; pfam07670
298386003488	FeoC like transcriptional regulator; Region: FeoC; pfam09012
298386003489	HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228
298386003490	Bacterial protein of unknown function (DUF924); Region: DUF924; pfam06041
298386003491	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298386003492	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298386003493	metal binding site [ion binding]; metal-binding site
298386003494	active site
298386003495	I-site; other site
298386003496	Arginyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: ArgS; COG0018
298386003497	Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016
298386003498	catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671
298386003499	active site
298386003500	HIGH motif; other site
298386003501	KMSK motif region; other site
298386003502	Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956
298386003503	tRNA binding surface [nucleotide binding]; other site
298386003504	anticodon binding site; other site
298386003505	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268
298386003506	putative metal binding site [ion binding]; other site
298386003507	formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027
298386003508	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
298386003509	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
298386003510	putative active site [active]
298386003511	putative substrate binding site [chemical binding]; other site
298386003512	putative cosubstrate binding site; other site
298386003513	catalytic site [active]
298386003514	Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519
298386003515	active site flap/lid [active]
298386003516	nucleophilic elbow; other site
298386003517	catalytic triad [active]
298386003518	Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499
298386003519	Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199
298386003520	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
298386003521	ATP binding site [chemical binding]; other site
298386003522	Helicase C-terminal domain; Region: Helicase_C_2; pfam13307
298386003523	tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725
298386003524	Glycoprotease family; Region: Peptidase_M22; pfam00814
298386003525	Outer membrane lipoprotein Slp family; Region: Slp; pfam03843
298386003526	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
298386003527	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
298386003528	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
298386003529	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974
298386003530	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298386003531	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
298386003532	acyl-activating enzyme (AAE) consensus motif; other site
298386003533	putative AMP binding site [chemical binding]; other site
298386003534	putative active site [active]
298386003535	putative CoA binding site [chemical binding]; other site
298386003536	ribonuclease D; Provisional; Region: PRK10829
298386003537	DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142
298386003538	catalytic site [active]
298386003539	putative active site [active]
298386003540	putative substrate binding site [chemical binding]; other site
298386003541	HRDC domain; Region: HRDC; pfam00570
298386003542	cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296
298386003543	cell division inhibitor MinD; Provisional; Region: PRK10818
298386003544	Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036
298386003545	Switch I; other site
298386003546	Switch II; other site
298386003547	septum formation inhibitor; Reviewed; Region: minC; PRK04804
298386003548	Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209
298386003549	Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775
298386003550	YcgL domain; Region: YcgL; pfam05166
298386003551	Transglycosylase SLT domain; Region: SLT_2; pfam13406
298386003552	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
298386003553	N-acetyl-D-glucosamine binding site [chemical binding]; other site
298386003554	global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947
298386003555	Domain in histone-like proteins of HNS family; Region: HNS; smart00528
298386003556	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
298386003557	thymidine kinase; Provisional; Region: PRK04296
298386003558	bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759
298386003559	Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139
298386003560	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534
298386003561	metal binding site [ion binding]; metal-binding site
298386003562	The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731
298386003563	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
298386003564	substrate binding site [chemical binding]; other site
298386003565	glutamase interaction surface [polypeptide binding]; other site
298386003566	HisA.  Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732
298386003567	Histidine biosynthesis protein; Region: His_biosynth; pfam00977
298386003568	catalytic residues [active]
298386003569	imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170
298386003570	Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748
298386003571	putative active site [active]
298386003572	oxyanion strand; other site
298386003573	catalytic triad [active]
298386003574	imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446
298386003575	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
298386003576	active site
298386003577	motif I; other site
298386003578	motif II; other site
298386003579	Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914
298386003580	putative active site pocket [active]
298386003581	4-fold oligomerization interface [polypeptide binding]; other site
298386003582	metal binding residues [ion binding]; metal-binding site
298386003583	3-fold/trimer interface [polypeptide binding]; other site
298386003584	histidinol-phosphate aminotransferase; Provisional; Region: PRK04635
298386003585	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
298386003586	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298386003587	homodimer interface [polypeptide binding]; other site
298386003588	catalytic residue [active]
298386003589	Histidinol dehydrogenase [Amino acid transport and metabolism]; Region: HisD; COG0141
298386003590	Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572
298386003591	NAD binding site [chemical binding]; other site
298386003592	dimerization interface [polypeptide binding]; other site
298386003593	product binding site; other site
298386003594	substrate binding site [chemical binding]; other site
298386003595	zinc binding site [ion binding]; other site
298386003596	catalytic residues [active]
298386003597	ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489
298386003598	ATP phosphoribosyltransferase; Region: hisG; TIGR00070
298386003599	ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455
298386003600	hypothetical protein; Provisional; Region: PRK02250
298386003601	SEC-C motif; Region: SEC-C; pfam02810
298386003602	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
298386003603	EAL domain; Region: EAL; pfam00563
298386003604	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
298386003605	Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398
298386003606	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
298386003607	putative active site [active]
298386003608	putative metal binding site [ion binding]; other site
298386003609	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
298386003610	active site
298386003611	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
298386003612	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
298386003613	active site
298386003614	HIGH motif; other site
298386003615	catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672
298386003616	KMSKS motif; other site
298386003617	Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963
298386003618	tRNA binding surface [nucleotide binding]; other site
298386003619	anticodon binding site; other site
298386003620	glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143
298386003621	Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600
298386003622	active site
298386003623	catalytic site [active]
298386003624	metal binding site [ion binding]; metal-binding site
298386003625	Ion transport protein; Region: Ion_trans; pfam00520
298386003626	Ion channel; Region: Ion_trans_2; pfam07885
298386003627	zinc-ribbon domain; Region: zf-ribbon_3; pfam13248
298386003628	hypothetical protein; Provisional; Region: PRK11111
298386003629	bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805
298386003630	Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122
298386003631	putative catalytic cysteine [active]
298386003632	C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178
298386003633	putative active site [active]
298386003634	metal binding site [ion binding]; metal-binding site
298386003635	short chain dehydrogenase; Provisional; Region: PRK08862
298386003636	classical (c) SDRs; Region: SDR_c; cd05233
298386003637	NAD(P) binding site [chemical binding]; other site
298386003638	active site
298386003639	Ribosomal S4P (gammaproteobacterial); Region: Ribosomal_S4Pg; pfam11993
298386003640	alpha-L-glutamate ligase-related protein; Region: rimK_rel_E_lig; TIGR02291
298386003641	Inactive transglutaminase fused to 7 transmembrane helices; Region: Transglut_i_TM; pfam14400
298386003642	7 transmembrane helices usually fused to an inactive transglutaminase; Region: 7TM_transglut; pfam14402
298386003643	Uncharacterized protein conserved in archaea [Posttranslational modification, protein turnover, chaperones]; Region: COG4067
298386003644	Methyltransferase domain; Region: Methyltransf_23; pfam13489
298386003645	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298386003646	S-adenosylmethionine binding site [chemical binding]; other site
298386003647	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298386003648	S-adenosylmethionine binding site [chemical binding]; other site
298386003649	Protein of unknown function DUF72; Region: DUF72; cl00777
298386003650	aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476
298386003651	EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317
298386003652	dimer interface [polypeptide binding]; other site
298386003653	anticodon binding site; other site
298386003654	Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777
298386003655	homodimer interface [polypeptide binding]; other site
298386003656	motif 1; other site
298386003657	active site
298386003658	motif 2; other site
298386003659	GAD domain; Region: GAD; pfam02938
298386003660	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
298386003661	active site
298386003662	motif 3; other site
298386003663	hypothetical protein; Validated; Region: PRK00110
298386003664	Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529
298386003665	active site
298386003666	putative DNA-binding cleft [nucleotide binding]; other site
298386003667	dimer interface [polypeptide binding]; other site
298386003668	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
298386003669	dimer interface [polypeptide binding]; other site
298386003670	Methyl-accepting chemotaxis protein (MCP) signalling domain; Region: MCPsignal; pfam00015
298386003671	putative CheW interface [polypeptide binding]; other site
298386003672	Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116
298386003673	RuvA N terminal domain; Region: RuvA_N; pfam01330
298386003674	RuvA, C-terminal domain; Region: RuvA_C; pfam07499
298386003675	Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080
298386003676	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298386003677	Walker A motif; other site
298386003678	ATP binding site [chemical binding]; other site
298386003679	Walker B motif; other site
298386003680	arginine finger; other site
298386003681	Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491
298386003682	excinuclease ABC subunit B; Provisional; Region: PRK05298
298386003683	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
298386003684	ATP binding site [chemical binding]; other site
298386003685	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
298386003686	nucleotide binding region [chemical binding]; other site
298386003687	ATP-binding site [chemical binding]; other site
298386003688	Ultra-violet resistance protein B; Region: UvrB; pfam12344
298386003689	UvrB/uvrC motif; Region: UVR; pfam02151
298386003690	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
298386003691	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386003692	active site
298386003693	phosphorylation site [posttranslational modification]
298386003694	intermolecular recognition site; other site
298386003695	dimerization interface [polypeptide binding]; other site
298386003696	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298386003697	Walker A motif; other site
298386003698	ATP binding site [chemical binding]; other site
298386003699	Walker B motif; other site
298386003700	arginine finger; other site
298386003701	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
298386003702	Hpt domain; Region: Hpt; pfam01627
298386003703	putative binding surface; other site
298386003704	active site
298386003705	conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826
298386003706	family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187
298386003707	phosphate binding site [ion binding]; other site
298386003708	putative substrate binding pocket [chemical binding]; other site
298386003709	dimer interface [polypeptide binding]; other site
298386003710	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
298386003711	molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164
298386003712	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
298386003713	FeS/SAM binding site; other site
298386003714	Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463
298386003715	MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420
298386003716	trimer interface [polypeptide binding]; other site
298386003717	dimer interface [polypeptide binding]; other site
298386003718	putative active site [active]
298386003719	Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754
298386003720	MoaE interaction surface [polypeptide binding]; other site
298386003721	MoeB interaction surface [polypeptide binding]; other site
298386003722	thiocarboxylated glycine; other site
298386003723	MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756
298386003724	MoaE homodimer interface [polypeptide binding]; other site
298386003725	MoaD interaction [polypeptide binding]; other site
298386003726	active site residues [active]
298386003727	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
298386003728	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
298386003729	trimer interface [polypeptide binding]; other site
298386003730	eyelet of channel; other site
298386003731	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
298386003732	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
298386003733	DNA binding residues [nucleotide binding]
298386003734	putative dimer interface [polypeptide binding]; other site
298386003735	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
298386003736	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
298386003737	peptide binding site [polypeptide binding]; other site
298386003738	oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471
298386003739	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386003740	dimer interface [polypeptide binding]; other site
298386003741	conserved gate region; other site
298386003742	putative PBP binding loops; other site
298386003743	ABC-ATPase subunit interface; other site
298386003744	oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406
298386003745	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
298386003746	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386003747	dimer interface [polypeptide binding]; other site
298386003748	conserved gate region; other site
298386003749	putative PBP binding loops; other site
298386003750	ABC-ATPase subunit interface; other site
298386003751	oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473
298386003752	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
298386003753	Walker A/P-loop; other site
298386003754	ATP binding site [chemical binding]; other site
298386003755	Q-loop/lid; other site
298386003756	ABC transporter signature motif; other site
298386003757	Walker B; other site
298386003758	D-loop; other site
298386003759	H-loop/switch region; other site
298386003760	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
298386003761	oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079
298386003762	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
298386003763	Walker A/P-loop; other site
298386003764	ATP binding site [chemical binding]; other site
298386003765	Q-loop/lid; other site
298386003766	ABC transporter signature motif; other site
298386003767	Walker B; other site
298386003768	D-loop; other site
298386003769	H-loop/switch region; other site
298386003770	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
298386003771	Cache domain; Region: Cache_1; pfam02743
298386003772	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298386003773	dimerization interface [polypeptide binding]; other site
298386003774	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
298386003775	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
298386003776	dimer interface [polypeptide binding]; other site
298386003777	putative CheW interface [polypeptide binding]; other site
298386003778	Cache domain; Region: Cache_1; pfam02743
298386003779	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298386003780	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298386003781	metal binding site [ion binding]; metal-binding site
298386003782	active site
298386003783	I-site; other site
298386003784	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
298386003785	Cupin superfamily protein; Region: Cupin_4; pfam08007
298386003786	Cupin-like domain; Region: Cupin_8; pfam13621
298386003787	Domain of unknown function DUF11; Region: DUF11; pfam01345
298386003788	Domain of unknown function DUF11; Region: DUF11; pfam01345
298386003789	Domain of unknown function DUF11; Region: DUF11; pfam01345
298386003790	Domain of unknown function DUF11; Region: DUF11; pfam01345
298386003791	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
298386003792	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
298386003793	ligand binding site [chemical binding]; other site
298386003794	NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965
298386003795	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
298386003796	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
298386003797	anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452
298386003798	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
298386003799	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
298386003800	Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730
298386003801	iron binding site [ion binding]; other site
298386003802	adenylosuccinate lyase; Provisional; Region: PRK09285
298386003803	PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598
298386003804	tetramer interface [polypeptide binding]; other site
298386003805	active site
298386003806	putative lysogenization regulator; Reviewed; Region: PRK00218
298386003807	tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054
298386003808	tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998
298386003809	23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394
298386003810	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
298386003811	active site
298386003812	isocitrate dehydrogenase; Validated; Region: PRK07362
298386003813	isocitrate dehydrogenase; Reviewed; Region: PRK07006
298386003814	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
298386003815	DNA-binding site [nucleotide binding]; DNA binding site
298386003816	RNA-binding motif; other site
298386003817	ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033
298386003818	ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034
298386003819	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298386003820	Walker A motif; other site
298386003821	ATP binding site [chemical binding]; other site
298386003822	Walker B motif; other site
298386003823	arginine finger; other site
298386003824	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298386003825	Walker A motif; other site
298386003826	ATP binding site [chemical binding]; other site
298386003827	Walker B motif; other site
298386003828	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
298386003829	S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451
298386003830	rRNA binding site [nucleotide binding]; other site
298386003831	predicted 30S ribosome binding site; other site
298386003832	arginyl-tRNA-protein transferase; Provisional; Region: PRK01305
298386003833	Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376
298386003834	Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377
298386003835	leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301
298386003836	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160
298386003837	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298386003838	Walker A/P-loop; other site
298386003839	ATP binding site [chemical binding]; other site
298386003840	Q-loop/lid; other site
298386003841	ABC transporter signature motif; other site
298386003842	Walker B; other site
298386003843	D-loop; other site
298386003844	H-loop/switch region; other site
298386003845	cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174
298386003846	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
298386003847	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298386003848	Walker A/P-loop; other site
298386003849	ATP binding site [chemical binding]; other site
298386003850	Q-loop/lid; other site
298386003851	ABC transporter signature motif; other site
298386003852	Walker B; other site
298386003853	D-loop; other site
298386003854	H-loop/switch region; other site
298386003855	thioredoxin reductase; Provisional; Region: PRK10262
298386003856	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
298386003857	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
298386003858	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
298386003859	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
298386003860	hexamer interface [polypeptide binding]; other site
298386003861	ligand binding site [chemical binding]; other site
298386003862	putative active site [active]
298386003863	NAD(P) binding site [chemical binding]; other site
298386003864	leucine-responsive transcriptional regulator; Provisional; Region: PRK11169
298386003865	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
298386003866	putative DNA binding site [nucleotide binding]; other site
298386003867	putative Zn2+ binding site [ion binding]; other site
298386003868	AsnC family; Region: AsnC_trans_reg; pfam01037
298386003869	Domain of unknown function (DUF4117); Region: DUF4117; pfam13491
298386003870	FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580
298386003871	Ftsk gamma domain; Region: Ftsk_gamma; pfam09397
298386003872	lipoprotein chaperone; Reviewed; Region: lolA; PRK00031
298386003873	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
298386003874	recombination factor protein RarA; Reviewed; Region: PRK13342
298386003875	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298386003876	Walker A motif; other site
298386003877	ATP binding site [chemical binding]; other site
298386003878	Walker B motif; other site
298386003879	arginine finger; other site
298386003880	MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002
298386003881	seryl-tRNA synthetase; Provisional; Region: PRK05431
298386003882	Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403
298386003883	Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770
298386003884	dimer interface [polypeptide binding]; other site
298386003885	active site
298386003886	motif 1; other site
298386003887	motif 2; other site
298386003888	motif 3; other site
298386003889	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
298386003890	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
298386003891	methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133
298386003892	catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814
298386003893	active site
298386003894	HIGH motif; other site
298386003895	KMSKS motif; other site
298386003896	Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957
298386003897	tRNA binding surface [nucleotide binding]; other site
298386003898	anticodon binding site; other site
298386003899	tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins.  This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties.  MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800
298386003900	dimer interface [polypeptide binding]; other site
298386003901	putative tRNA-binding site [nucleotide binding]; other site
298386003902	antiporter inner membrane protein; Provisional; Region: PRK11670
298386003903	MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037
298386003904	Walker A motif; other site
298386003905	Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572
298386003906	Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023
298386003907	ATP-binding site [chemical binding]; other site
298386003908	Sugar specificity; other site
298386003909	Pyrimidine base specificity; other site
298386003910	AsmA family; Region: AsmA; pfam05170
298386003911	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
298386003912	putative assembly protein; Provisional; Region: PRK10833
298386003913	Virulence factor BrkB; Region: Virul_fac_BrkB; cl07918
298386003914	FOG: CBS domain [General function prediction only]; Region: COG0517
298386003915	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in  the acetoin utilization proteins in bacteria. Acetoin is a product of fermentative metabolism in many prokaryotic and eukaryotic microorganisms.  They produce...; Region: CBS_pair_ACT_assoc; cd04584
298386003916	Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307
298386003917	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489
298386003918	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
298386003919	Phosphate-starvation-inducible E; Region: PsiE; cl01264
298386003920	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP; Region: CobA_CobO_BtuR; cl17276
298386003921	ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109
298386003922	ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561
298386003923	homodimer interface [polypeptide binding]; other site
298386003924	Walker A motif; other site
298386003925	ATP binding site [chemical binding]; other site
298386003926	hydroxycobalamin binding site [chemical binding]; other site
298386003927	Walker B motif; other site
298386003928	cobalamin synthase; Reviewed; Region: cobS; PRK00235
298386003929	Phosphoribosyltransferase; Region: DBI_PRT; pfam02277
298386003930	Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439
298386003931	putative dimer interface [polypeptide binding]; other site
298386003932	active site pocket [active]
298386003933	putative cataytic base [active]
298386003934	Protein of unknown function (DUF3313); Region: DUF3313; pfam11769
298386003935	Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394
298386003936	Low molecular weight phosphatase family; Region: LMWPc; cd00115
298386003937	active site
298386003938	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
298386003939	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
298386003940	Sulfate transporter family; Region: Sulfate_transp; pfam00916
298386003941	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
298386003942	Ribonucleases G and E [Translation, ribosomal structure and biogenesis]; Region: CafA; COG1530
298386003943	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
298386003944	homodimer interface [polypeptide binding]; other site
298386003945	oligonucleotide binding site [chemical binding]; other site
298386003946	23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025
298386003947	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
298386003948	RNA binding surface [nucleotide binding]; other site
298386003949	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
298386003950	active site
298386003951	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
298386003952	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
298386003953	motif II; other site
298386003954	Maf-like protein; Region: Maf; pfam02545
298386003955	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
298386003956	active site
298386003957	dimer interface [polypeptide binding]; other site
298386003958	hypothetical protein; Provisional; Region: PRK11193
298386003959	50S ribosomal protein L32; Validated; Region: rpmF; PRK01110
298386003960	putative phosphate acyltransferase; Provisional; Region: PRK05331
298386003961	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352
298386003962	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
298386003963	dimer interface [polypeptide binding]; other site
298386003964	active site
298386003965	CoA binding pocket [chemical binding]; other site
298386003966	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
298386003967	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
298386003968	3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557
298386003969	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
298386003970	NAD(P) binding site [chemical binding]; other site
298386003971	homotetramer interface [polypeptide binding]; other site
298386003972	homodimer interface [polypeptide binding]; other site
298386003973	active site
298386003974	acyl carrier protein; Provisional; Region: acpP; PRK00982
298386003975	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK08722
298386003976	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
298386003977	dimer interface [polypeptide binding]; other site
298386003978	active site
298386003979	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
298386003980	ADCL_like: 4-Amino-4-deoxychorismate lyase:  is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate.  Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559
298386003981	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298386003982	catalytic residue [active]
298386003983	YceG-like family; Region: YceG; pfam02618
298386003984	proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010
298386003985	dimerization interface [polypeptide binding]; other site
298386003986	thymidylate kinase; Validated; Region: tmk; PRK00698
298386003987	Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672
298386003988	TMP-binding site; other site
298386003989	ATP-binding site [chemical binding]; other site
298386003990	DNA polymerase III, delta' subunit; Region: holB; TIGR00678
298386003991	DNA polymerase III subunit delta'; Validated; Region: PRK08485
298386003992	DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115
298386003993	Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099
298386003994	TatD like proteins;  E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310
298386003995	active site
298386003996	PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089
298386003997	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
298386003998	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
298386003999	active site turn [active]
298386004000	phosphorylation site [posttranslational modification]
298386004001	Predicted membrane protein [Function unknown]; Region: COG2431
298386004002	Predicted signal transduction protein [Signal transduction mechanisms]; Region: COG1639
298386004003	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
298386004004	TfoX N-terminal domain; Region: TfoX_N; pfam04993
298386004005	TfoX C-terminal domain; Region: TfoX_C; pfam04994
298386004006	DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086
298386004007	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386004008	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
298386004009	dimerization interface [polypeptide binding]; other site
298386004010	substrate binding pocket [chemical binding]; other site
298386004011	sulfation-dependent quorum factor, Ax21 family; Region: Y_sulf_Ax21; TIGR04273
298386004012	D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183
298386004013	Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052
298386004014	putative ligand binding site [chemical binding]; other site
298386004015	putative NAD binding site [chemical binding]; other site
298386004016	catalytic site [active]
298386004017	Response regulator receiver domain; Region: Response_reg; pfam00072
298386004018	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386004019	active site
298386004020	phosphorylation site [posttranslational modification]
298386004021	intermolecular recognition site; other site
298386004022	dimerization interface [polypeptide binding]; other site
298386004023	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
298386004024	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386004025	active site
298386004026	phosphorylation site [posttranslational modification]
298386004027	intermolecular recognition site; other site
298386004028	dimerization interface [polypeptide binding]; other site
298386004029	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
298386004030	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
298386004031	ligand binding site [chemical binding]; other site
298386004032	flexible hinge region; other site
298386004033	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298386004034	dimer interface [polypeptide binding]; other site
298386004035	phosphorylation site [posttranslational modification]
298386004036	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298386004037	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386004038	ATP binding site [chemical binding]; other site
298386004039	Mg2+ binding site [ion binding]; other site
298386004040	G-X-G motif; other site
298386004041	Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097
298386004042	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339
298386004043	FOG: CBS domain [General function prediction only]; Region: COG0517
298386004044	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_16; cd04629
298386004045	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
298386004046	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
298386004047	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
298386004048	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
298386004049	transmembrane helices; other site
298386004050	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
298386004051	ligand binding site [chemical binding]; other site
298386004052	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298386004053	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386004054	ATP binding site [chemical binding]; other site
298386004055	Mg2+ binding site [ion binding]; other site
298386004056	G-X-G motif; other site
298386004057	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
298386004058	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386004059	active site
298386004060	phosphorylation site [posttranslational modification]
298386004061	intermolecular recognition site; other site
298386004062	dimerization interface [polypeptide binding]; other site
298386004063	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386004064	zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033
298386004065	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
298386004066	metal-binding site [ion binding]
298386004067	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
298386004068	uridine phosphorylase; Provisional; Region: PRK11178
298386004069	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
298386004070	Domain of unknown function (DUF1887); Region: DUF1887; pfam09002
298386004071	trehalose repressor; Provisional; Region: treR; PRK09492
298386004072	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
298386004073	DNA binding site [nucleotide binding]
298386004074	domain linker motif; other site
298386004075	Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542
298386004076	dimerization interface [polypeptide binding]; other site
298386004077	ligand binding site [chemical binding]; other site
298386004078	PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007
298386004079	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
298386004080	active site turn [active]
298386004081	phosphorylation site [posttranslational modification]
298386004082	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
298386004083	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
298386004084	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
298386004085	Ca binding site [ion binding]; other site
298386004086	active site
298386004087	catalytic site [active]
298386004088	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
298386004089	TIGR01666 family membrane protein; Region: YCCS
298386004090	FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805
298386004091	Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515
298386004092	DNA helicase IV; Provisional; Region: helD; PRK11054
298386004093	DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462
298386004094	Part of AAA domain; Region: AAA_19; pfam13245
298386004095	Family description; Region: UvrD_C_2; pfam13538
298386004096	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
298386004097	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR5; cd08271
298386004098	putative NAD(P) binding site [chemical binding]; other site
298386004099	substrate binding site [chemical binding]; other site
298386004100	Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422
298386004101	active site
298386004102	dimer interfaces [polypeptide binding]; other site
298386004103	catalytic residues [active]
298386004104	TMAO reductase system periplasmic protein TorT; Region: TMAO_TorT; TIGR02955
298386004105	TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306
298386004106	putative ligand binding site [chemical binding]; other site
298386004107	TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956
298386004108	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
298386004109	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298386004110	dimer interface [polypeptide binding]; other site
298386004111	phosphorylation site [posttranslational modification]
298386004112	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386004113	ATP binding site [chemical binding]; other site
298386004114	Mg2+ binding site [ion binding]; other site
298386004115	G-X-G motif; other site
298386004116	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386004117	active site
298386004118	phosphorylation site [posttranslational modification]
298386004119	intermolecular recognition site; other site
298386004120	dimerization interface [polypeptide binding]; other site
298386004121	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
298386004122	putative binding surface; other site
298386004123	active site
298386004124	Peptidase family C69; Region: Peptidase_C69; cl17793
298386004125	elongation factor G; Reviewed; Region: PRK00007
298386004126	Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886
298386004127	G1 box; other site
298386004128	putative GEF interaction site [polypeptide binding]; other site
298386004129	GTP/Mg2+ binding site [chemical binding]; other site
298386004130	Switch I region; other site
298386004131	G2 box; other site
298386004132	G3 box; other site
298386004133	Switch II region; other site
298386004134	G4 box; other site
298386004135	G5 box; other site
298386004136	EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088
298386004137	EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434
298386004138	EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G.  Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713
298386004139	Serine/threonine protein kinase involved in cell cycle control [Signal transduction mechanisms / Cell division and chromosome partitioning]; Region: RIO1; COG1718
298386004140	RIO kinase family; RIO1, RIO3 and similar proteins, catalytic domain. The RIO kinase catalytic domain family is part of a larger superfamily, that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein...; Region: RIO1_like; cd05145
298386004141	ATP binding site [chemical binding]; other site
298386004142	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
298386004143	RNA binding surface [nucleotide binding]; other site
298386004144	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_M15_4; pfam13539
298386004145	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
298386004146	non-specific DNA binding site [nucleotide binding]; other site
298386004147	salt bridge; other site
298386004148	sequence-specific DNA binding site [nucleotide binding]; other site
298386004149	Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660
298386004150	Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248
298386004151	active site
298386004152	catalytic tetrad [active]
298386004153	Rhodanese Homology Domain; Region: RHOD; smart00450
298386004154	active site residue [active]
298386004155	Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897
298386004156	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
298386004157	active site residue [active]
298386004158	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
298386004159	active site residue [active]
298386004160	hypothetical protein; Validated; Region: PRK01415
298386004161	Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518
298386004162	active site residue [active]
298386004163	putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142
298386004164	Uncharacterized protein conserved in bacteria, putative lipoprotein [Function unknown]; Region: LprI; COG4461
298386004165	Protein of unknown function (DUF1311); Region: DUF1311; pfam07007
298386004166	Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864
298386004167	META domain; Region: META; pfam03724
298386004168	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
298386004169	Walker A motif; other site
298386004170	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_22; cd04681
298386004171	nudix motif; other site
298386004172	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
298386004173	putative catalytic site [active]
298386004174	putative metal binding site [ion binding]; other site
298386004175	putative phosphate binding site [ion binding]; other site
298386004176	Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108
298386004177	dimer interface [polypeptide binding]; other site
298386004178	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
298386004179	active site
298386004180	citrylCoA binding site [chemical binding]; other site
298386004181	oxalacetate/citrate binding site [chemical binding]; other site
298386004182	coenzyme A binding site [chemical binding]; other site
298386004183	catalytic triad [active]
298386004184	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_2; pfam13532
298386004185	Domain of unknown function (DUF3541); Region: DUF3541; pfam12060
298386004186	AmmeMemoRadiSam system protein A; Region: AmmeMemoSam_A; TIGR04335
298386004187	AMMECR1; Region: AMMECR1; pfam01871
298386004188	Memo (mediator of ErbB2-driven cell motility) is co-precipitated with the C terminus of ErbB2, a protein involved in cell motility; Region: MEMO_like; cd07361
298386004189	putative ligand binding pocket/active site [active]
298386004190	putative metal binding site [ion binding]; other site
298386004191	AmmeMemoRadiSam system radical SAM enzyme; Region: AmmeMemoSam_rS; TIGR04337
298386004192	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
298386004193	FeS/SAM binding site; other site
298386004194	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
298386004195	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298386004196	dimerization interface [polypeptide binding]; other site
298386004197	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
298386004198	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
298386004199	dimer interface [polypeptide binding]; other site
298386004200	putative CheW interface [polypeptide binding]; other site
298386004201	6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536
298386004202	MOSC domain; Region: MOSC; pfam03473
298386004203	3-alpha domain; Region: 3-alpha; pfam03475
298386004204	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298386004205	binding surface
298386004206	TPR motif; other site
298386004207	cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125
298386004208	cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659
298386004209	cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149
298386004210	cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148
298386004211	Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301
298386004212	cytochrome c nitrate reductase biogenesis protein NrfE; Region: cyt_nit_nrfE; TIGR03145
298386004213	TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010
298386004214	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
298386004215	catalytic residues [active]
298386004216	central insert; other site
298386004217	Cytochrome C biogenesis protein; Region: CcmH; cl01179
298386004218	Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015
298386004219	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
298386004220	cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197
298386004221	active site
298386004222	Surface antigen [Cell envelope biogenesis, outer membrane]; Region: LipA; COG4520
298386004223	Glycosyl hydrolase family 20, domain 2; Region: Glyco_hydro_20b; pfam02838
298386004224	Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728
298386004225	A functionally uncharacterized subgroup of  the Glycosyl hydrolase family 20 (GH20) catalytic domain found in proteins similar to the chitobiase of Serratia marcescens, a beta-N-1,4-acetylhexosaminidase that hydrolyzes the beta-1,4-glycosidic linkages in...; Region: GH20_chitobiase-like_1; cd06570
298386004226	active site
298386004227	Beta-N-acetylhexosaminidases of glycosyl hydrolase family 20 (GH20) catalyze the removal of beta-1,4-linked N-acetyl-D-hexosamine residues from the non-reducing ends of N-acetyl-beta-D-hexosaminides including N-acetylglucosides and N-acetylgalactosides; Region: GH20_hexosaminidase; cl02948
298386004228	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
298386004229	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
298386004230	Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616
298386004231	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Bacterial Cryptic D-Serine Dehydratase; Region: PLPDE_III_cryptic_DSD; cd06818
298386004232	dimer interface [polypeptide binding]; other site
298386004233	active site
298386004234	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
298386004235	substrate binding site [chemical binding]; other site
298386004236	catalytic residue [active]
298386004237	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
298386004238	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
298386004239	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
298386004240	putative active site [active]
298386004241	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
298386004242	D-aminoacylases (N-acyl-D-Amino acid amidohydrolases) catalyze the hydrolysis of N-acyl-D-amino acids to produce the corresponding D-amino acids, which are used as intermediates in the synthesis of pesticides, bioactive peptides, and antibiotics; Region: D-aminoacylase; cd01297
298386004243	active site
298386004244	putative substrate binding pocket [chemical binding]; other site
298386004245	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298386004246	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
298386004247	homotrimer interaction site [polypeptide binding]; other site
298386004248	putative active site [active]
298386004249	Solute carrier 5 family, sodium/glucose transporters and related proteins; solute-binding domain; Region: SLC5sbd; cd10322
298386004250	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
298386004251	Na binding site [ion binding]; other site
298386004252	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
298386004253	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
298386004254	substrate binding site [chemical binding]; other site
298386004255	ATP binding site [chemical binding]; other site
298386004256	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
298386004257	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
298386004258	active site
298386004259	intersubunit interface [polypeptide binding]; other site
298386004260	catalytic residue [active]
298386004261	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
298386004262	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
298386004263	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
298386004264	Uncharacterized protein conserved in bacteria (DUF2330); Region: DUF2330; cl01827
298386004265	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
298386004266	Protein of unknown function (DUF3012); Region: DUF3012; pfam11216
298386004267	LamB/YcsF family of  lactam utilization protein; Region: LamB_YcsF_like; cd10787
298386004268	putative active site [active]
298386004269	Allophanate hydrolase subunit 1; Region: AHS1; pfam02682
298386004270	Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; COG2049
298386004271	Allophanate hydrolase subunit 2; Region: AHS2; smart00797
298386004272	GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661
298386004273	putative active site pocket [active]
298386004274	dimerization interface [polypeptide binding]; other site
298386004275	putative catalytic residue [active]
298386004276	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
298386004277	long-chain-fatty-acid--CoA ligase; Validated; Region: PRK07656
298386004278	Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936
298386004279	acyl-activating enzyme (AAE) consensus motif; other site
298386004280	putative AMP binding site [chemical binding]; other site
298386004281	putative active site [active]
298386004282	putative CoA binding site [chemical binding]; other site
298386004283	Protein of unknown function (DUF2947); Region: DUF2947; pfam11163
298386004284	Pirin; Region: Pirin; pfam02678
298386004285	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
298386004286	Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315
298386004287	cytoplasmic alpha-amylase; Reviewed; Region: PRK09441
298386004288	active site
298386004289	Ca binding site [ion binding]; other site
298386004290	catalytic site [active]
298386004291	Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447
298386004292	nudix motif; other site
298386004293	PAP2_like_2 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_2; cd03392
298386004294	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
298386004295	active site
298386004296	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
298386004297	FAD binding domain; Region: FAD_binding_4; pfam01565
298386004298	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
298386004299	Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333
298386004300	amphipathic channel; other site
298386004301	Asn-Pro-Ala signature motifs; other site
298386004302	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386004303	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386004304	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
298386004305	Cation efflux family; Region: Cation_efflux; cl00316
298386004306	Uncharacterized conserved protein [Function unknown]; Region: COG1432
298386004307	LabA_like proteins; Region: LabA; cd10911
298386004308	putative metal binding site [ion binding]; other site
298386004309	Protein of unknown function (DUF2884); Region: DUF2884; pfam11101
298386004310	The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541
298386004311	dimerization interface [polypeptide binding]; other site
298386004312	substrate binding site [chemical binding]; other site
298386004313	active site
298386004314	calcium binding site [ion binding]; other site
298386004315	hypothetical protein; Provisional; Region: PRK01254
298386004316	Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497
298386004317	Domain of unknown function (DUF3362); Region: DUF3362; pfam11842
298386004318	Domain of unknown function (DUF3596); Region: DUF3596; pfam12167
298386004319	Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582
298386004320	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
298386004321	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
298386004322	active site
298386004323	DNA binding site [nucleotide binding]
298386004324	Int/Topo IB signature motif; other site
298386004325	Putative excisionase (DUF1233); Region: DUF1233; pfam06806
298386004326	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
298386004327	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298386004328	non-specific DNA binding site [nucleotide binding]; other site
298386004329	salt bridge; other site
298386004330	sequence-specific DNA binding site [nucleotide binding]; other site
298386004331	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298386004332	non-specific DNA binding site [nucleotide binding]; other site
298386004333	salt bridge; other site
298386004334	sequence-specific DNA binding site [nucleotide binding]; other site
298386004335	Replicative DNA helicase [DNA replication, recombination, and repair]; Region: DnaB; COG0305
298386004336	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
298386004337	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
298386004338	Walker A motif; other site
298386004339	ATP binding site [chemical binding]; other site
298386004340	Walker B motif; other site
298386004341	Phage protein; Region: DUF3653; pfam12375
298386004342	Domain of unknown function (DUF4062); Region: DUF4062; pfam13271
298386004343	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase; Region: PHP_HisPPase; cd07432
298386004344	DNA polymerase alpha chain like domain; Region: POLIIIAc; smart00481
298386004345	active site
298386004346	AAA domain; Region: AAA_21; pfam13304
298386004347	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298386004348	ABC transporter signature motif; other site
298386004349	Walker B; other site
298386004350	D-loop; other site
298386004351	H-loop/switch region; other site
298386004352	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
298386004353	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
298386004354	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386004355	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
298386004356	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
298386004357	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
298386004358	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
298386004359	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298386004360	non-specific DNA binding site [nucleotide binding]; other site
298386004361	salt bridge; other site
298386004362	sequence-specific DNA binding site [nucleotide binding]; other site
298386004363	Predicted Zn peptidase [Amino acid transport and metabolism]; Region: COG2856
298386004364	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386004365	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
298386004366	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
298386004367	active site
298386004368	metal binding site [ion binding]; metal-binding site
298386004369	Protein of unknown function (DUF1643); Region: DUF1643; pfam07799
298386004370	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386004371	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
298386004372	active site
298386004373	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
298386004374	Putative transposase; Region: Y2_Tnp; pfam04986
298386004375	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
298386004376	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
298386004377	active site
298386004378	DNA binding site [nucleotide binding]
298386004379	Int/Topo IB signature motif; other site
298386004380	stationary phase growth adaptation protein; Provisional; Region: PRK09717
298386004381	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
298386004382	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
298386004383	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
298386004384	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
298386004385	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386004386	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
298386004387	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
298386004388	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
298386004389	active site
298386004390	tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238
298386004391	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
298386004392	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
298386004393	catalytic residue [active]
298386004394	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
298386004395	Carbohydrate-selective porin, OprB family; Region: OprB; pfam04966
298386004396	Bacterial Ig-like domain (group 2); Region: Big_2; cl02708
298386004397	Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969
298386004398	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
298386004399	Active Sites [active]
298386004400	Domain of unknown function (DUF3440); Region: DUF3440; pfam11922
298386004401	ParB-like nuclease domain; Region: ParBc; pfam02195
298386004402	Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475
298386004403	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_2; cd07253
298386004404	dimer interface [polypeptide binding]; other site
298386004405	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298386004406	metal binding site [ion binding]; metal-binding site
298386004407	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
298386004408	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
298386004409	active site
298386004410	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
298386004411	Phage-related protein [Function unknown]; Region: COG4695; cl01923
298386004412	Phage portal protein; Region: Phage_portal; pfam04860
298386004413	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
298386004414	oligomer interface [polypeptide binding]; other site
298386004415	active site residues [active]
298386004416	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
298386004417	Phage capsid family; Region: Phage_capsid; pfam05065
298386004418	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
298386004419	oligomerization interface [polypeptide binding]; other site
298386004420	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
298386004421	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
298386004422	Homeodomain-like domain; Region: HTH_23; pfam13384
298386004423	Winged helix-turn helix; Region: HTH_29; pfam13551
298386004424	Winged helix-turn helix; Region: HTH_33; pfam13592
298386004425	DDE superfamily endonuclease; Region: DDE_3; pfam13358
298386004426	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
298386004427	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
298386004428	putative deacylase active site [active]
298386004429	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
298386004430	Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360
298386004431	C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654
298386004432	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
298386004433	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386004434	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386004435	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
298386004436	dimerization interface [polypeptide binding]; other site
298386004437	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298386004438	Major Facilitator Superfamily; Region: MFS_1; pfam07690
298386004439	putative substrate translocation pore; other site
298386004440	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298386004441	dimerization interface [polypeptide binding]; other site
298386004442	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
298386004443	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
298386004444	dimer interface [polypeptide binding]; other site
298386004445	putative CheW interface [polypeptide binding]; other site
298386004446	glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379
298386004447	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
298386004448	Cysteine-rich domain; Region: CCG; pfam02754
298386004449	Cysteine-rich domain; Region: CCG; pfam02754
298386004450	anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329
298386004451	glycerol-3-phosphate dehydrogenase, anaerobic, B subunit; Region: glycerol3P_GlpB; TIGR03378
298386004452	sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101
298386004453	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
298386004454	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298386004455	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298386004456	metal binding site [ion binding]; metal-binding site
298386004457	active site
298386004458	I-site; other site
298386004459	Homeodomain-like domain; Region: HTH_23; pfam13384
298386004460	Winged helix-turn helix; Region: HTH_29; pfam13551
298386004461	Winged helix-turn helix; Region: HTH_33; pfam13592
298386004462	DDE superfamily endonuclease; Region: DDE_3; pfam13358
298386004463	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
298386004464	Domain of unknown function (DUF4250); Region: DUF4250; pfam14056
298386004465	DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421
298386004466	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386004467	The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441
298386004468	putative dimerization interface [polypeptide binding]; other site
298386004469	5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222
298386004470	CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312
298386004471	THF binding site; other site
298386004472	CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311
298386004473	substrate binding site [chemical binding]; other site
298386004474	THF binding site; other site
298386004475	zinc-binding site [ion binding]; other site
298386004476	META domain; Region: META; pfam03724
298386004477	Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668
298386004478	Mechanosensitive ion channel; Region: MS_channel; pfam00924
298386004479	integrase; Provisional; Region: int; PHA02601
298386004480	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
298386004481	Lipase (class 3).  Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface.  A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519
298386004482	active site flap/lid [active]
298386004483	nucleophilic elbow; other site
298386004484	catalytic triad [active]
298386004485	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386004486	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386004487	phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14253
298386004488	ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260
298386004489	Walker A/P-loop; other site
298386004490	ATP binding site [chemical binding]; other site
298386004491	Q-loop/lid; other site
298386004492	ABC transporter signature motif; other site
298386004493	Walker B; other site
298386004494	D-loop; other site
298386004495	H-loop/switch region; other site
298386004496	phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974
298386004497	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386004498	dimer interface [polypeptide binding]; other site
298386004499	conserved gate region; other site
298386004500	putative PBP binding loops; other site
298386004501	ABC-ATPase subunit interface; other site
298386004502	ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573
298386004503	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386004504	dimer interface [polypeptide binding]; other site
298386004505	conserved gate region; other site
298386004506	putative PBP binding loops; other site
298386004507	ABC-ATPase subunit interface; other site
298386004508	PBP superfamily domain; Region: PBP_like_2; cl17296
298386004509	Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531
298386004510	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
298386004511	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298386004512	dimerization interface [polypeptide binding]; other site
298386004513	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
298386004514	dimer interface [polypeptide binding]; other site
298386004515	putative CheW interface [polypeptide binding]; other site
298386004516	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386004517	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386004518	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
298386004519	putative effector binding pocket; other site
298386004520	dimerization interface [polypeptide binding]; other site
298386004521	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
298386004522	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
298386004523	Nucleoside recognition; Region: Gate; pfam07670
298386004524	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
298386004525	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
298386004526	Uncharacterized conserved protein [Function unknown]; Region: COG1359
298386004527	transcriptional regulator; Provisional; Region: PRK10632
298386004528	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386004529	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
298386004530	dimerization interface [polypeptide binding]; other site
298386004531	TRAP-type mannitol/chloroaromatic compound transport system, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT1; COG4663
298386004532	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
298386004533	Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; cl01181
298386004534	TRAP-type mannitol/chloroaromatic compound transport system, large permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FcbT3; COG4664
298386004535	DctM-like transporters; Region: DctM; pfam06808
298386004536	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
298386004537	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298386004538	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
298386004539	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
298386004540	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
298386004541	FAD binding domain; Region: FAD_binding_4; pfam01565
298386004542	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
298386004543	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
298386004544	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
298386004545	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
298386004546	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
298386004547	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
298386004548	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
298386004549	Cysteine-rich domain; Region: CCG; pfam02754
298386004550	Cysteine-rich domain; Region: CCG; pfam02754
298386004551	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
298386004552	L-lactate permease; Region: Lactate_perm; cl00701
298386004553	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386004554	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386004555	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
298386004556	putative effector binding pocket; other site
298386004557	dimerization interface [polypeptide binding]; other site
298386004558	Fels-1 Prophage Protein-like; Region: Fels1; pfam05666
298386004559	Protein of unknown function (DUF805); Region: DUF805; pfam05656
298386004560	Ribosome recycling factor; Region: RRF_GI; pfam12614
298386004561	CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385
298386004562	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
298386004563	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
298386004564	Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524
298386004565	active site residue [active]
298386004566	Predicted transporter component [General function prediction only]; Region: COG2391
298386004567	Domain of unknown function (DUF4341); Region: DUF4341; pfam14241
298386004568	Predicted transporter component [General function prediction only]; Region: COG2391
298386004569	Sulphur transport; Region: Sulf_transp; pfam04143
298386004570	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
298386004571	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
298386004572	active site
298386004573	SAM binding site [chemical binding]; other site
298386004574	homodimer interface [polypeptide binding]; other site
298386004575	nitrite transporter NirC; Provisional; Region: PRK11562
298386004576	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
298386004577	nitrite reductase subunit NirD; Provisional; Region: PRK14989
298386004578	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
298386004579	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
298386004580	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
298386004581	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
298386004582	nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397
298386004583	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
298386004584	Phosphorylase superfamily; Region: PNP_UDP_1; cl00303
298386004585	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
298386004586	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
298386004587	ligand binding site [chemical binding]; other site
298386004588	flexible hinge region; other site
298386004589	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
298386004590	aromatic amino acid transport protein; Region: araaP; TIGR00837
298386004591	ATP adenylyltransferase (5',5'''-P-1,P-4-tetraphosphate phosphorylase II) [Nucleotide transport and metabolism]; Region: APA2; COG4360
298386004592	ATP adenylyltransferase; Region: ATP_transf; pfam09830
298386004593	PcfJ-like protein; Region: PcfJ; pfam14284
298386004594	Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791
298386004595	NlpC/P60 family; Region: NLPC_P60; pfam00877
298386004596	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386004597	Maltose-binding periplasmic proteins/domains [Carbohydrate transport and metabolism]; Region: MalE; COG2182
298386004598	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
298386004599	HAMP domain; Region: HAMP; pfam00672
298386004600	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298386004601	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298386004602	metal binding site [ion binding]; metal-binding site
298386004603	active site
298386004604	I-site; other site
298386004605	SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307
298386004606	SWIM/SEC-C metal-binding motif protein, PBPRA1643 family; Region: SWIM_PBPRA1643; TIGR04102
298386004607	glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722
298386004608	Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479
298386004609	Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781
298386004610	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
298386004611	6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400
298386004612	putative active site [active]
298386004613	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
298386004614	6-phosphogluconate dehydrogenase; Validated; Region: PRK09287
298386004615	6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393
298386004616	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
298386004617	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
298386004618	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298386004619	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
298386004620	active site
298386004621	metal binding site [ion binding]; metal-binding site
298386004622	Protein of unknown function (DUF3108); Region: DUF3108; pfam11306
298386004623	formyltetrahydrofolate deformylase; Reviewed; Region: PRK13011
298386004624	N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875
298386004625	Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648
298386004626	putative active site [active]
298386004627	putative substrate binding site [chemical binding]; other site
298386004628	putative cosubstrate binding site; other site
298386004629	catalytic site [active]
298386004630	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
298386004631	Serine hydrolase (FSH1); Region: FSH1; pfam03959
298386004632	Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861
298386004633	GST_N family, 2 repeats of the N-terminal domain of soluble GSTs (2 GST_N) subfamily; composed of uncharacterized proteins. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a...; Region: GST_N_2GST_N; cd03041
298386004634	putative C-terminal domain interface [polypeptide binding]; other site
298386004635	putative GSH binding site (G-site) [chemical binding]; other site
298386004636	putative dimer interface [polypeptide binding]; other site
298386004637	GST_N family, 2 repeats of the N-terminal domain of soluble GSTs (2 GST_N) subfamily; composed of uncharacterized proteins. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a...; Region: GST_N_2GST_N; cd03041
298386004638	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
298386004639	putative C-terminal domain interface [polypeptide binding]; other site
298386004640	putative GSH binding site (G-site) [chemical binding]; other site
298386004641	putative dimer interface [polypeptide binding]; other site
298386004642	Peptidase inhibitor I9; Region: Inhibitor_I9; pfam05922
298386004643	Peptidase S8 family domain in Subtilisin proteins; Region: Peptidases_S8_Subtilisin_subset; cd07477
298386004644	active site
298386004645	catalytic residues [active]
298386004646	PA_VapT_like: Protease-associated domain containing proteins like VapT from Vibrio metschnikovii strain RH530. This group contains various PA domain-containing proteins similar to V. metschnikovii VapT, including the serine alkaline protease SapSh from...; Region: PA_VapT_like; cd04817
298386004647	PA/subtilisin-like domain interface [polypeptide binding]; other site
298386004648	Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459
298386004649	catalytic residues [active]
298386004650	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
298386004651	Ubiquitin-like proteins; Region: UBQ; cl00155
298386004652	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863
298386004653	Protein of unknown function (DUF4238); Region: DUF4238; pfam14022
298386004654	2-Nitropropane dioxygenase (NPD)-like domain, associated with the (acyl-carrier-protein) S-malonyltransferase  FabD. NPD is part of the nitroalkaneoxidizing enzyme family, that catalyzes oxidative denitrification of nitroalkanes to their corresponding...; Region: NPD_FabD; cd04742
298386004655	FMN binding site [chemical binding]; other site
298386004656	Dioxygenases related to 2-nitropropane dioxygenase [General function prediction only]; Region: COG2070
298386004657	substrate binding site [chemical binding]; other site
298386004658	putative catalytic residue [active]
298386004659	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
298386004660	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
298386004661	active site
298386004662	Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938
298386004663	active site
298386004664	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
298386004665	active site 2 [active]
298386004666	dimer interface [polypeptide binding]; other site
298386004667	active site 1 [active]
298386004668	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
298386004669	active site 1 [active]
298386004670	dimer interface [polypeptide binding]; other site
298386004671	active site 2 [active]
298386004672	PfaB family protein; Region: pfaB_fam; TIGR02816
298386004673	polyketide-type polyunsaturated fatty acid synthase PfaA; Region: omega_3_PfaA; TIGR02813
298386004674	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
298386004675	active site
298386004676	(acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331
298386004677	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
298386004678	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
298386004679	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
298386004680	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
298386004681	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
298386004682	ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953
298386004683	putative NADP binding site [chemical binding]; other site
298386004684	active site
298386004685	Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826
298386004686	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
298386004687	active site
298386004688	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258
298386004689	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
298386004690	dimer interface [polypeptide binding]; other site
298386004691	active site
298386004692	CoA binding pocket [chemical binding]; other site
298386004693	haloalkane dehalogenase; Provisional; Region: PRK03592
298386004694	peptide synthase; Provisional; Region: PRK09274
298386004695	Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_1; cd05910
298386004696	acyl-activating enzyme (AAE) consensus motif; other site
298386004697	putative AMP binding site [chemical binding]; other site
298386004698	putative active site [active]
298386004699	putative CoA binding site [chemical binding]; other site
298386004700	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298386004701	3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073
298386004702	NAD(P) binding site [chemical binding]; other site
298386004703	active site
298386004704	Vibrio chemotaxis protein N terminus; Region: MCP_N; pfam05581
298386004705	Cache domain; Region: Cache_1; pfam02743
298386004706	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
298386004707	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298386004708	dimerization interface [polypeptide binding]; other site
298386004709	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
298386004710	dimer interface [polypeptide binding]; other site
298386004711	putative CheW interface [polypeptide binding]; other site
298386004712	trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102
298386004713	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
298386004714	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
298386004715	molybdopterin cofactor binding site [chemical binding]; other site
298386004716	substrate binding site [chemical binding]; other site
298386004717	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
298386004718	molybdopterin cofactor binding site; other site
298386004719	periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161
298386004720	trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162
298386004721	non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414
298386004722	ATP binding site [chemical binding]; other site
298386004723	active site
298386004724	substrate binding site [chemical binding]; other site
298386004725	Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210
298386004726	Part of AAA domain; Region: AAA_19; pfam13245
298386004727	Family description; Region: UvrD_C_2; pfam13538
298386004728	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386004729	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386004730	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
298386004731	dimerization interface [polypeptide binding]; other site
298386004732	Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574
298386004733	YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300
298386004734	active site
298386004735	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298386004736	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
298386004737	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
298386004738	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
298386004739	substrate binding pocket [chemical binding]; other site
298386004740	membrane-bound complex binding site; other site
298386004741	hinge residues; other site
298386004742	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
298386004743	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386004744	dimer interface [polypeptide binding]; other site
298386004745	conserved gate region; other site
298386004746	putative PBP binding loops; other site
298386004747	ABC-ATPase subunit interface; other site
298386004748	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
298386004749	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
298386004750	Walker A/P-loop; other site
298386004751	ATP binding site [chemical binding]; other site
298386004752	Q-loop/lid; other site
298386004753	ABC transporter signature motif; other site
298386004754	Walker B; other site
298386004755	D-loop; other site
298386004756	H-loop/switch region; other site
298386004757	Protein of unknown function (DUF445); Region: DUF445; pfam04286
298386004758	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
298386004759	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
298386004760	class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300
298386004761	S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818
298386004762	substrate binding site [chemical binding]; other site
298386004763	catalytic Zn binding site [ion binding]; other site
298386004764	NAD binding site [chemical binding]; other site
298386004765	structural Zn binding site [ion binding]; other site
298386004766	dimer interface [polypeptide binding]; other site
298386004767	putative transporter; Provisional; Region: PRK11021
298386004768	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
298386004769	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
298386004770	putative DNA binding site [nucleotide binding]; other site
298386004771	putative Zn2+ binding site [ion binding]; other site
298386004772	AsnC family; Region: AsnC_trans_reg; pfam01037
298386004773	molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290
298386004774	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037
298386004775	nucleotide binding site [chemical binding]; other site
298386004776	Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071
298386004777	Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins.  IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470
298386004778	putative dimer interface [polypeptide binding]; other site
298386004779	Protein of unknown function (DUF3080); Region: DUF3080; pfam11279
298386004780	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386004781	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386004782	chaperone protein TorD; Validated; Region: torD; PRK04976
298386004783	trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102
298386004784	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
298386004785	molybdopterin cofactor binding site [chemical binding]; other site
298386004786	substrate binding site [chemical binding]; other site
298386004787	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
298386004788	molybdopterin cofactor binding site; other site
298386004789	trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032
298386004790	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
298386004791	DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766
298386004792	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386004793	active site
298386004794	phosphorylation site [posttranslational modification]
298386004795	intermolecular recognition site; other site
298386004796	dimerization interface [polypeptide binding]; other site
298386004797	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298386004798	DNA binding site [nucleotide binding]
298386004799	putative pyridoxal-dependent aspartate 1-decarboxylase; Region: NOD_PanD_pyr; TIGR03799
298386004800	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
298386004801	catalytic residue [active]
298386004802	Protein of unknown function (DUF2860); Region: DUF2860; pfam11059
298386004803	putative transcription regulator; Region: PHA01082
298386004804	Phage protein; Region: DUF3653; pfam12375
298386004805	RelB antitoxin; Region: RelB; cl01171
298386004806	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
298386004807	uncharacterized bacterial and archaeal solute carrier 6 subfamily; solute-binding domain; Region: SLC6sbd_u1; cd10334
298386004808	Na2 binding site [ion binding]; other site
298386004809	putative substrate binding site 1 [chemical binding]; other site
298386004810	Na binding site 1 [ion binding]; other site
298386004811	putative substrate binding site 2 [chemical binding]; other site
298386004812	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
298386004813	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
298386004814	nucleophile elbow; other site
298386004815	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
298386004816	DHH family; Region: DHH; pfam01368
298386004817	DHHA2 domain; Region: DHHA2; pfam02833
298386004818	GGGtGRT protein; Region: GGGtGRT; pfam14057
298386004819	NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822
298386004820	Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cl00528
298386004821	alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561
298386004822	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
298386004823	dimerization interface [polypeptide binding]; other site
298386004824	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522
298386004825	active site
298386004826	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cl00522
298386004827	multidrug resistance protein D; Provisional; Region: emrD; PRK11652
298386004828	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298386004829	putative substrate translocation pore; other site
298386004830	dsDNA-mimic protein; Reviewed; Region: PRK05094
298386004831	CSS motif domain associated with EAL; Region: CSS-motif; pfam12792
298386004832	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
298386004833	hypothetical protein; Provisional; Region: PRK02135
298386004834	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298386004835	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
298386004836	Transposase IS200 like; Region: Y1_Tnp; pfam01797
298386004837	dipeptide/tripeptide permease B; Provisional; Region: PRK10207
298386004838	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298386004839	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
298386004840	metal binding triad [ion binding]; metal-binding site
298386004841	DNA polymerase II; Reviewed; Region: PRK05762
298386004842	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784
298386004843	active site
298386004844	catalytic site [active]
298386004845	substrate binding site [chemical binding]; other site
298386004846	DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537
298386004847	active site
298386004848	metal-binding site
298386004849	Predicted Fe-S protein [General function prediction only]; Region: COG3313
298386004850	Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495
298386004851	5S rRNA interface [nucleotide binding]; other site
298386004852	CTC domain interface [polypeptide binding]; other site
298386004853	L16 interface [polypeptide binding]; other site
298386004854	TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786
298386004855	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
298386004856	N-terminal plug; other site
298386004857	ligand-binding site [chemical binding]; other site
298386004858	isoaspartyl dipeptidase; Provisional; Region: PRK10657
298386004859	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298386004860	active site
298386004861	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
298386004862	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
298386004863	Homeodomain-like domain; Region: HTH_23; pfam13384
298386004864	Winged helix-turn helix; Region: HTH_29; pfam13551
298386004865	Winged helix-turn helix; Region: HTH_33; pfam13592
298386004866	DDE superfamily endonuclease; Region: DDE_3; pfam13358
298386004867	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
298386004868	DEAD-like helicases superfamily; Region: DEXDc; smart00487
298386004869	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
298386004870	ATP binding site [chemical binding]; other site
298386004871	putative Mg++ binding site [ion binding]; other site
298386004872	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
298386004873	Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513
298386004874	nucleotide binding region [chemical binding]; other site
298386004875	ATP-binding site [chemical binding]; other site
298386004876	Double zinc ribbon; Region: DZR; pfam12773
298386004877	Arsenite efflux pump ACR3 and related permeases [Inorganic ion transport and metabolism]; Region: ACR3; COG0798
298386004878	arsenical-resistance protein; Region: acr3; TIGR00832
298386004879	Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953
298386004880	arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291
298386004881	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
298386004882	P loop; other site
298386004883	Nucleotide binding site [chemical binding]; other site
298386004884	DTAP/Switch II; other site
298386004885	Switch I; other site
298386004886	ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035
298386004887	DTAP/Switch II; other site
298386004888	Switch I; other site
298386004889	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298386004890	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
298386004891	Coenzyme A binding pocket [chemical binding]; other site
298386004892	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
298386004893	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
298386004894	RNA binding surface [nucleotide binding]; other site
298386004895	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
298386004896	active site
298386004897	uracil binding [chemical binding]; other site
298386004898	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
298386004899	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298386004900	putative substrate translocation pore; other site
298386004901	Protein of unknown function (DUF2913); Region: DUF2913; pfam11140
298386004902	bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102
298386004903	Protein of unknown function (DUF2913); Region: DUF2913; pfam11140
298386004904	BCCT family transporter; Region: BCCT; pfam02028
298386004905	Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702
298386004906	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298386004907	NAD(P) binding site [chemical binding]; other site
298386004908	active site
298386004909	Protein of unknown function (DUF2867); Region: DUF2867; pfam11066
298386004910	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
298386004911	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_8; cd13134
298386004912	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
298386004913	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
298386004914	Walker A/P-loop; other site
298386004915	ATP binding site [chemical binding]; other site
298386004916	Q-loop/lid; other site
298386004917	ABC transporter signature motif; other site
298386004918	Walker B; other site
298386004919	D-loop; other site
298386004920	H-loop/switch region; other site
298386004921	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
298386004922	FtsX-like permease family; Region: FtsX; pfam02687
298386004923	Hydroxyneurosporene synthase (CrtC); Region: CrtC; pfam07143
298386004924	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
298386004925	M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665
298386004926	putative metal binding site [ion binding]; other site
298386004927	dimer interface [polypeptide binding]; other site
298386004928	Fusaric acid resistance protein family; Region: FUSC; pfam04632
298386004929	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
298386004930	Protein of unknown function (DUF1656); Region: DUF1656; pfam07869
298386004931	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
298386004932	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
298386004933	HlyD family secretion protein; Region: HlyD_3; pfam13437
298386004934	Ion channel; Region: Ion_trans_2; pfam07885
298386004935	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
298386004936	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
298386004937	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
298386004938	ABC-ATPase subunit  interface; other site
298386004939	dimer interface [polypeptide binding]; other site
298386004940	putative PBP binding regions; other site
298386004941	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
298386004942	ABC-ATPase subunit  interface; other site
298386004943	dimer interface [polypeptide binding]; other site
298386004944	putative PBP binding regions; other site
298386004945	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
298386004946	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
298386004947	intersubunit interface [polypeptide binding]; other site
298386004948	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
298386004949	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
298386004950	Walker A/P-loop; other site
298386004951	ATP binding site [chemical binding]; other site
298386004952	Q-loop/lid; other site
298386004953	ABC transporter signature motif; other site
298386004954	Walker B; other site
298386004955	D-loop; other site
298386004956	H-loop/switch region; other site
298386004957	ferrichrome receptor precursor protein; Provisional; Region: PRK14050
298386004958	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
298386004959	N-terminal plug; other site
298386004960	ligand-binding site [chemical binding]; other site
298386004961	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
298386004962	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
298386004963	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
298386004964	Walker A/P-loop; other site
298386004965	ATP binding site [chemical binding]; other site
298386004966	Q-loop/lid; other site
298386004967	ABC transporter signature motif; other site
298386004968	Walker B; other site
298386004969	D-loop; other site
298386004970	H-loop/switch region; other site
298386004971	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386004972	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386004973	Protein of unknown function, DUF258; Region: DUF258; pfam03193
298386004974	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
298386004975	G1 box; other site
298386004976	GTP/Mg2+ binding site [chemical binding]; other site
298386004977	G2 box; other site
298386004978	Switch I region; other site
298386004979	G3 box; other site
298386004980	Switch II region; other site
298386004981	Ribosome anti-association factor IF6 binds the large ribosomal subunit and prevents the two subunits from associating during translation initiation. IF6 comprises a family of translation factors that includes both eukaryotic (eIF6) and archeal (aIF6)...; Region: IF6; cl00241
298386004982	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882
298386004983	G1 box; other site
298386004984	GTP/Mg2+ binding site [chemical binding]; other site
298386004985	G2 box; other site
298386004986	Switch I region; other site
298386004987	G3 box; other site
298386004988	Switch II region; other site
298386004989	G4 box; other site
298386004990	DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303
298386004991	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
298386004992	DNA binding site [nucleotide binding]
298386004993	domain linker motif; other site
298386004994	Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274
298386004995	dimerization interface [polypeptide binding]; other site
298386004996	ligand binding site [chemical binding]; other site
298386004997	bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109
298386004998	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
298386004999	active site
298386005000	phosphorylation site [posttranslational modification]
298386005001	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
298386005002	dimerization domain swap beta strand [polypeptide binding]; other site
298386005003	regulatory protein interface [polypeptide binding]; other site
298386005004	active site
298386005005	regulatory phosphorylation site [posttranslational modification]; other site
298386005006	Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105
298386005007	1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164
298386005008	putative substrate binding site [chemical binding]; other site
298386005009	putative ATP binding site [chemical binding]; other site
298386005010	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
298386005011	active site
298386005012	P-loop; other site
298386005013	phosphorylation site [posttranslational modification]
298386005014	PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712
298386005015	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
298386005016	active site
298386005017	P-loop; other site
298386005018	phosphorylation site [posttranslational modification]
298386005019	PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427
298386005020	Uncharacterized protein family (UPF0081); Region: UPF0081; cl17278
298386005021	arginine-ornithine antiporter; Region: arg_ornith_anti; TIGR03810
298386005022	Spore germination protein; Region: Spore_permease; cl17796
298386005023	Cell division inhibitor SulA; Region: SulA; cl01880
298386005024	Topoisomer_IB_N: N-terminal DNA binding fragment found in eukaryotic DNA topoisomerase (topo) IB proteins similar to the monomeric yeast and human topo I and heterodimeric topo I from Leishmania donvanni. Topo I enzymes are divided into:  topo type IA; Region: Topoisomer_IB_N; cl02774
298386005025	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386005026	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386005027	Protein of unknown function (DUF3732); Region: DUF3732; pfam12532
298386005028	Nuclease-related domain; Region: NERD; pfam08378
298386005029	AAA domain; Region: AAA_11; pfam13086
298386005030	Part of AAA domain; Region: AAA_19; pfam13245
298386005031	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
298386005032	AAA domain; Region: AAA_30; pfam13604
298386005033	AAA domain; Region: AAA_12; pfam13087
298386005034	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
298386005035	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
298386005036	Transposase [DNA replication, recombination, and repair]; Region: COG5433
298386005037	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
298386005038	Transposase [DNA replication, recombination, and repair]; Region: COG5433
298386005039	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
298386005040	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
298386005041	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386005042	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
298386005043	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
298386005044	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
298386005045	Nuclease-related domain; Region: NERD; pfam08378
298386005046	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
298386005047	substrate binding site [chemical binding]; other site
298386005048	Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515
298386005049	activation loop (A-loop); other site
298386005050	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
298386005051	active site
298386005052	ATP binding site [chemical binding]; other site
298386005053	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
298386005054	AAA domain; Region: AAA_30; pfam13604
298386005055	AAA domain; Region: AAA_12; pfam13087
298386005056	Domain of unknown function (DUF4016); Region: DUF4016; pfam13208
298386005057	tellurite resistance protein terB; Region: terB; cd07176
298386005058	putative metal binding site [ion binding]; other site
298386005059	P-loop Domain of unknown function (DUF2791); Region: DUF2791; pfam10923
298386005060	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
298386005061	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
298386005062	ATP binding site [chemical binding]; other site
298386005063	putative Mg++ binding site [ion binding]; other site
298386005064	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
298386005065	nucleotide binding region [chemical binding]; other site
298386005066	ATP-binding site [chemical binding]; other site
298386005067	Cys-rich peptide radical SAM maturase CcpM; Region: rSAM_ocin_clost; TIGR04068
298386005068	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
298386005069	FeS/SAM binding site; other site
298386005070	Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190
298386005071	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
298386005072	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
298386005073	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
298386005074	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
298386005075	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386005076	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
298386005077	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
298386005078	FeS/SAM binding site; other site
298386005079	haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282
298386005080	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
298386005081	active site
298386005082	motif I; other site
298386005083	motif II; other site
298386005084	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
298386005085	Ribosomal L22e protein family; Region: Ribosomal_L22e; cl03348
298386005086	Catalytic domain of uncharacterized hypothetical proteins similar to eukaryotic phosphatidylinositol-specific phospholipase C, X domain containing proteins; Region: PI-PLCXDc_like_1; cd08620
298386005087	putative active site [active]
298386005088	catalytic site [active]
298386005089	Integrase core domain; Region: rve; pfam00665
298386005090	AAA domain; Region: AAA_22; pfam13401
298386005091	Bacterial TniB protein; Region: TniB; pfam05621
298386005092	DNA polymerase II large subunit; Provisional; Region: PRK14714
298386005093	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
298386005094	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
298386005095	putative active site [active]
298386005096	putative NTP binding site [chemical binding]; other site
298386005097	putative nucleic acid binding site [nucleotide binding]; other site
298386005098	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
298386005099	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
298386005100	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
298386005101	Transposase [DNA replication, recombination, and repair]; Region: COG5433
298386005102	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386005103	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
298386005104	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
298386005105	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
298386005106	Transposase IS200 like; Region: Y1_Tnp; pfam01797
298386005107	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: Unknown ABO13168; Region: LPLAT_ABO13168-like; cd07988
298386005108	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
298386005109	putative acyl-acceptor binding pocket; other site
298386005110	The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cl00320
298386005111	putative tRNA-binding site [nucleotide binding]; other site
298386005112	Putative transposase; Region: Y2_Tnp; pfam04986
298386005113	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386005114	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
298386005115	active site
298386005116	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
298386005117	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
298386005118	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386005119	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
298386005120	SWIM/SEC-C metal-binding motif protein, PBPRA1643 family; Region: SWIM_PBPRA1643; TIGR04102
298386005121	SEC-C motif; Region: SEC-C; pfam02810
298386005122	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298386005123	NmrA-like family; Region: NmrA; pfam05368
298386005124	NAD(P) binding site [chemical binding]; other site
298386005125	active site
298386005126	Na+/H+ antiporter family; Region: Na_H_antiporter; pfam03553
298386005127	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
298386005128	catalytic residue [active]
298386005129	Copper resistance protein D; Region: CopD; cl00563
298386005130	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
298386005131	Transposase; Region: DEDD_Tnp_IS110; pfam01548
298386005132	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
298386005133	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
298386005134	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298386005135	Coenzyme A binding pocket [chemical binding]; other site
298386005136	Phosphotransferase enzyme family; Region: APH; pfam01636
298386005137	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
298386005138	substrate binding site [chemical binding]; other site
298386005139	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
298386005140	GST_N family, Omega-like subfamily; composed of uncharacterized proteins with similarity to class Omega GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_Omega_like; cd03060
298386005141	putative GSH binding site (G-site) [chemical binding]; other site
298386005142	active site cysteine [active]
298386005143	putative C-terminal domain interface [polypeptide binding]; other site
298386005144	putative dimer interface [polypeptide binding]; other site
298386005145	C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196
298386005146	putative N-terminal domain interface [polypeptide binding]; other site
298386005147	putative dimer interface [polypeptide binding]; other site
298386005148	putative substrate binding pocket (H-site) [chemical binding]; other site
298386005149	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
298386005150	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298386005151	Walker A/P-loop; other site
298386005152	ATP binding site [chemical binding]; other site
298386005153	Q-loop/lid; other site
298386005154	ABC transporter signature motif; other site
298386005155	Walker B; other site
298386005156	D-loop; other site
298386005157	H-loop/switch region; other site
298386005158	ABC transporter; Region: ABC_tran_2; pfam12848
298386005159	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
298386005160	Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409
298386005161	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
298386005162	active site
298386005163	metal binding site [ion binding]; metal-binding site
298386005164	Predicted membrane protein [Function unknown]; Region: COG1288
298386005165	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
298386005166	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
298386005167	ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228
298386005168	Walker A/P-loop; other site
298386005169	ATP binding site [chemical binding]; other site
298386005170	Q-loop/lid; other site
298386005171	ABC transporter signature motif; other site
298386005172	Walker B; other site
298386005173	D-loop; other site
298386005174	H-loop/switch region; other site
298386005175	ABC-type transport system involved in cytochrome bd biosynthesis, ATPase and permease components [Energy production and conversion / Posttranslational modification, protein turnover, chaperones]; Region: CydD; COG4988
298386005176	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
298386005177	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298386005178	Walker A/P-loop; other site
298386005179	ATP binding site [chemical binding]; other site
298386005180	Q-loop/lid; other site
298386005181	ABC transporter signature motif; other site
298386005182	Walker B; other site
298386005183	D-loop; other site
298386005184	H-loop/switch region; other site
298386005185	Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021
298386005186	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
298386005187	acyl-activating enzyme (AAE) consensus motif; other site
298386005188	active site
298386005189	AMP binding site [chemical binding]; other site
298386005190	substrate binding site [chemical binding]; other site
298386005191	salicylate synthase; Region: salicyl_syn; TIGR03494
298386005192	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
298386005193	Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208
298386005194	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298386005195	active site
298386005196	Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693
298386005197	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
298386005198	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298386005199	CoA binding site [chemical binding]; other site
298386005200	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
298386005201	Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319
298386005202	polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833
298386005203	Beta-ketoacyl synthase; Region: PKS_KS; smart00825
298386005204	active site
298386005205	malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128
298386005206	Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827
298386005207	ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274
298386005208	This enzymatic domain is part of bacterial polyketide synthases; Region: PKS_KR; smart00822
298386005209	NADP binding site [chemical binding]; other site
298386005210	active site
298386005211	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
298386005212	Condensation domain; Region: Condensation; pfam00668
298386005213	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
298386005214	Nonribosomal peptide synthase; Region: NRPS; pfam08415
298386005215	Methyltransferase domain; Region: Methyltransf_23; pfam13489
298386005216	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298386005217	S-adenosylmethionine binding site [chemical binding]; other site
298386005218	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
298386005219	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
298386005220	Condensation domain; Region: Condensation; pfam00668
298386005221	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
298386005222	Nonribosomal peptide synthase; Region: NRPS; pfam08415
298386005223	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298386005224	acyl-activating enzyme (AAE) consensus motif; other site
298386005225	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
298386005226	Condensation domain; Region: Condensation; pfam00668
298386005227	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
298386005228	Nonribosomal peptide synthase; Region: NRPS; pfam08415
298386005229	The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114
298386005230	acyl-activating enzyme (AAE) consensus motif; other site
298386005231	AMP binding site [chemical binding]; other site
298386005232	Methyltransferase domain; Region: Methyltransf_23; pfam13489
298386005233	Methyltransferase domain; Region: Methyltransf_12; pfam08242
298386005234	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298386005235	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
298386005236	Condensation domain; Region: Condensation; pfam00668
298386005237	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
298386005238	Nonribosomal peptide synthase; Region: NRPS; pfam08415
298386005239	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
298386005240	siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718
298386005241	muropeptide transporter; Validated; Region: ampG; cl17669
298386005242	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
298386005243	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
298386005244	N-terminal plug; other site
298386005245	ligand-binding site [chemical binding]; other site
298386005246	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
298386005247	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298386005248	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
298386005249	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298386005250	Transposase IS200 like; Region: Y1_Tnp; pfam01797
298386005251	Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504
298386005252	SnoaL-like domain; Region: SnoaL_3; pfam13474
298386005253	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298386005254	dipeptide/tripeptide permease B; Provisional; Region: PRK10207
298386005255	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
298386005256	Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756
298386005257	thiopurine S-methyltransferase; Reviewed; Region: PRK13255
298386005258	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298386005259	S-adenosylmethionine binding site [chemical binding]; other site
298386005260	phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288
298386005261	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298386005262	ATP-grasp domain; Region: ATP-grasp; pfam02222
298386005263	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
298386005264	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
298386005265	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
298386005266	EamA-like transporter family; Region: EamA; pfam00892
298386005267	cytidine deaminase; Provisional; Region: PRK09027
298386005268	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
298386005269	active site
298386005270	catalytic motif [active]
298386005271	Zn binding site [ion binding]; other site
298386005272	Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283
298386005273	active site
298386005274	catalytic motif [active]
298386005275	Zn binding site [ion binding]; other site
298386005276	LrgB-like family; Region: LrgB; cl00596
298386005277	hypothetical protein; Provisional; Region: PRK01821
298386005278	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
298386005279	DNA binding site [nucleotide binding]
298386005280	exonuclease I; Provisional; Region: sbcB; PRK11779
298386005281	N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138
298386005282	active site
298386005283	catalytic site [active]
298386005284	substrate binding site [chemical binding]; other site
298386005285	Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411
298386005286	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
298386005287	active site
298386005288	DNA binding site [nucleotide binding]
298386005289	Int/Topo IB signature motif; other site
298386005290	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
298386005291	Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016
298386005292	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
298386005293	Putative transposase; Region: Y2_Tnp; pfam04986
298386005294	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
298386005295	active site
298386005296	DNA binding site [nucleotide binding]
298386005297	Int/Topo IB signature motif; other site
298386005298	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386005299	Homeodomain-like domain; Region: HTH_23; pfam13384
298386005300	Winged helix-turn helix; Region: HTH_29; pfam13551
298386005301	Winged helix-turn helix; Region: HTH_33; pfam13592
298386005302	DDE superfamily endonuclease; Region: DDE_3; pfam13358
298386005303	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
298386005304	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
298386005305	Winged helix-turn helix; Region: HTH_29; pfam13551
298386005306	Homeodomain-like domain; Region: HTH_32; pfam13565
298386005307	Integrase core domain; Region: rve; pfam00665
298386005308	Integrase core domain; Region: rve_3; pfam13683
298386005309	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
298386005310	Transposase; Region: HTH_Tnp_1; cl17663
298386005311	Transposase; Region: HTH_Tnp_1; cl17663
298386005312	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386005313	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
298386005314	putative Mg++ binding site [ion binding]; other site
298386005315	Competence protein CoiA-like family; Region: CoiA; cl11541
298386005316	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386005317	Homeodomain-like domain; Region: HTH_23; pfam13384
298386005318	Winged helix-turn helix; Region: HTH_29; pfam13551
298386005319	Winged helix-turn helix; Region: HTH_33; pfam13592
298386005320	DDE superfamily endonuclease; Region: DDE_3; pfam13358
298386005321	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
298386005322	cellulose synthase operon protein YhjU; Region: cellulose_yhjU; TIGR03368
298386005323	cellulose biosynthesis protein BcsE; Region: cellulose_bcsE; TIGR03369
298386005324	cellulose synthase operon protein YhjQ; Region: cellulose_yhjQ; TIGR03371
298386005325	cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498
298386005326	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
298386005327	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
298386005328	DXD motif; other site
298386005329	PilZ domain; Region: PilZ; pfam07238
298386005330	cellulose synthase regulator protein; Provisional; Region: PRK11114
298386005331	endo-1,4-D-glucanase; Provisional; Region: PRK11097
298386005332	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298386005333	binding surface
298386005334	TPR motif; other site
298386005335	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298386005336	binding surface
298386005337	TPR motif; other site
298386005338	TPR repeat; Region: TPR_11; pfam13414
298386005339	heme biosynthesis-associated TPR protein; Region: TPR_hemY_coli; TIGR00540
298386005340	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298386005341	binding surface
298386005342	TPR motif; other site
298386005343	Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420
298386005344	glyceraldehyde-3-phosphate dehydrogenase; Reviewed; Region: PRK08289
298386005345	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
298386005346	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
298386005347	anhydro-N-acetylmuramic acid kinase; Reviewed; Region: anmK; PRK09585
298386005348	maltodextrin glucosidase; Provisional; Region: PRK10785
298386005349	N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857
298386005350	homodimer interface [polypeptide binding]; other site
298386005351	Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338
298386005352	active site
298386005353	homodimer interface [polypeptide binding]; other site
298386005354	catalytic site [active]
298386005355	Domain of unknown function (DUF4174); Region: DUF4174; pfam13778
298386005356	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386005357	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386005358	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
298386005359	putative effector binding pocket; other site
298386005360	dimerization interface [polypeptide binding]; other site
298386005361	pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825
298386005362	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
298386005363	substrate-cofactor binding pocket; other site
298386005364	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298386005365	catalytic residue [active]
298386005366	L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396
298386005367	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
298386005368	NAD(P) binding site [chemical binding]; other site
298386005369	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
298386005370	This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799
298386005371	putative ADP-binding pocket [chemical binding]; other site
298386005372	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
298386005373	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761
298386005374	active site
298386005375	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
298386005376	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
298386005377	ABC transporter ATP-binding protein; Provisional; Region: PRK15064
298386005378	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
298386005379	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298386005380	Walker A/P-loop; other site
298386005381	ATP binding site [chemical binding]; other site
298386005382	ABC transporter signature motif; other site
298386005383	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
298386005384	Walker B; other site
298386005385	ABC transporter; Region: ABC_tran_2; pfam12848
298386005386	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
298386005387	Uncharacterized BCR, YaiI/YqxD family COG1671; Region: DUF188; pfam02639
298386005388	Putative ParB-like nuclease; Region: ParBc_2; pfam08857
298386005389	Protein of unknown function (DUF3334); Region: DUF3334; pfam11813
298386005390	Glutathione S-transferase, N-terminal domain; Region: GST_N_3; pfam13417
298386005391	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386005392	Response regulator receiver domain; Region: Response_reg; pfam00072
298386005393	active site
298386005394	phosphorylation site [posttranslational modification]
298386005395	intermolecular recognition site; other site
298386005396	dimerization interface [polypeptide binding]; other site
298386005397	Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776
298386005398	PAS domain; Region: PAS; smart00091
298386005399	PAS domain; Region: PAS_9; pfam13426
298386005400	putative active site [active]
298386005401	heme pocket [chemical binding]; other site
298386005402	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298386005403	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298386005404	metal binding site [ion binding]; metal-binding site
298386005405	active site
298386005406	I-site; other site
298386005407	Protein of unknown function (DUF3802); Region: DUF3802; pfam12290
298386005408	Uncharacterized conserved protein [Function unknown]; Region: COG3148
298386005409	fructokinase; Reviewed; Region: PRK09557
298386005410	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
298386005411	nucleotide binding site [chemical binding]; other site
298386005412	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
298386005413	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
298386005414	ATP binding site [chemical binding]; other site
298386005415	Mg++ binding site [ion binding]; other site
298386005416	motif III; other site
298386005417	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
298386005418	nucleotide binding region [chemical binding]; other site
298386005419	ATP-binding site [chemical binding]; other site
298386005420	PEP synthetase regulatory protein; Provisional; Region: PRK05339
298386005421	phosphoenolpyruvate synthase; Validated; Region: PRK06464
298386005422	Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326
298386005423	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
298386005424	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
298386005425	tellurium resistance terB-like protein, subgroup 2; Region: terB_like_2; cd07313
298386005426	putative metal binding site [ion binding]; other site
298386005427	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
298386005428	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298386005429	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386005430	ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131
298386005431	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
298386005432	ATP binding site [chemical binding]; other site
298386005433	putative Mg++ binding site [ion binding]; other site
298386005434	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
298386005435	nucleotide binding region [chemical binding]; other site
298386005436	ATP-binding site [chemical binding]; other site
298386005437	Helicase associated domain (HA2); Region: HA2; pfam04408
298386005438	Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717
298386005439	Domain of unknown function (DUF3418); Region: DUF3418; pfam11898
298386005440	Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826
298386005441	Peptidase family U32; Region: Peptidase_U32; pfam01136
298386005442	Collagenase; Region: DUF3656; pfam12392
298386005443	Peptidase family U32; Region: Peptidase_U32; cl03113
298386005444	Uncharacterized copper-binding protein [Inorganic ion transport and metabolism]; Region: COG4454
298386005445	PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089
298386005446	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
298386005447	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
298386005448	active site turn [active]
298386005449	phosphorylation site [posttranslational modification]
298386005450	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
298386005451	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cl17220
298386005452	nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514
298386005453	Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401
298386005454	active site
298386005455	aminopeptidase N; Provisional; Region: pepN; PRK14015
298386005456	Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600
298386005457	active site
298386005458	Zn binding site [ion binding]; other site
298386005459	Protein of unknown function (DUF2835); Region: DUF2835; pfam11197
298386005460	Bacterial NAD-glutamate dehydrogenase; Region: Bac_GDH; pfam05088
298386005461	Glutamate/Leucine/Phenylalanine/Valine dehydrogenase; Region: ELFV_dehydrog; smart00839
298386005462	dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286
298386005463	Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738
298386005464	quinone interaction residues [chemical binding]; other site
298386005465	active site
298386005466	catalytic residues [active]
298386005467	FMN binding site [chemical binding]; other site
298386005468	substrate binding site [chemical binding]; other site
298386005469	Protein of unknown function (DUF1379); Region: DUF1379; pfam07126
298386005470	23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783
298386005471	THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715
298386005472	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
298386005473	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298386005474	S-adenosylmethionine binding site [chemical binding]; other site
298386005475	Glutaredoxin-like domain (DUF836); Region: DUF836; pfam05768
298386005476	ABC transporter ATPase component; Reviewed; Region: PRK11147
298386005477	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
298386005478	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298386005479	Walker A/P-loop; other site
298386005480	ATP binding site [chemical binding]; other site
298386005481	Q-loop/lid; other site
298386005482	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
298386005483	ABC transporter signature motif; other site
298386005484	Walker B; other site
298386005485	D-loop; other site
298386005486	ABC transporter; Region: ABC_tran_2; pfam12848
298386005487	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
298386005488	Protein of unknown function (DUF3466); Region: DUF3466; pfam11949
298386005489	FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287
298386005490	active site 1 [active]
298386005491	dimer interface [polypeptide binding]; other site
298386005492	active site 2 [active]
298386005493	Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067
298386005494	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
298386005495	Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097
298386005496	Protein of unknown function (DUF3634); Region: DUF3634; pfam12321
298386005497	Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378
298386005498	trimer interface [polypeptide binding]; other site
298386005499	putative Zn binding site [ion binding]; other site
298386005500	Flagellar protein YcgR; Region: YcgR_2; pfam12945
298386005501	PilZ domain; Region: PilZ; pfam07238
298386005502	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
298386005503	DNA binding site [nucleotide binding]
298386005504	Antibiotic biosynthesis monooxygenase; Region: ABM; pfam03992
298386005505	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386005506	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
298386005507	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
298386005508	MerR HTH family regulatory protein; Region: MerR_1; pfam13411
298386005509	DNA binding residues [nucleotide binding]
298386005510	Methyltransferase domain; Region: Methyltransf_23; pfam13489
298386005511	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298386005512	S-adenosylmethionine binding site [chemical binding]; other site
298386005513	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
298386005514	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298386005515	Coenzyme A binding pocket [chemical binding]; other site
298386005516	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386005517	GTPase RsgA; Reviewed; Region: PRK01889
298386005518	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
298386005519	GTPase/Zn-binding domain interface [polypeptide binding]; other site
298386005520	GTP/Mg2+ binding site [chemical binding]; other site
298386005521	G4 box; other site
298386005522	G5 box; other site
298386005523	G1 box; other site
298386005524	Switch I region; other site
298386005525	G2 box; other site
298386005526	G3 box; other site
298386005527	Switch II region; other site
298386005528	putative transcription regulator; Region: PHA01082
298386005529	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
298386005530	lysozyme_like domain.  This contains several members including Soluble Lytic Transglycosylases (SLT), Goose Egg-White Lysozymes (GEWL), Hen Egg-White Lysozymes (HEWL), chitinases, bacteriophage lambda lysozymes, endolysins, autolysins, and chitosanases; Region: lysozyme_like; cl00222
298386005531	catalytic residue [active]
298386005532	Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112
298386005533	AAA domain; Region: AAA_12; pfam13087
298386005534	Part of AAA domain; Region: AAA_19; pfam13245
298386005535	Uncharacterized conserved protein [Function unknown]; Region: COG1479
298386005536	Protein of unknown function DUF262; Region: DUF262; pfam03235
298386005537	Protein of unknown function (DUF1524); Region: DUF1524; pfam07510
298386005538	Uncharacterized conserved protein [Function unknown]; Region: COG1479
298386005539	Protein of unknown function DUF262; Region: DUF262; pfam03235
298386005540	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298386005541	AAA domain; Region: AAA_21; pfam13304
298386005542	Walker A/P-loop; other site
298386005543	ATP binding site [chemical binding]; other site
298386005544	AAA domain; Region: AAA_21; pfam13304
298386005545	EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737
298386005546	Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420
298386005547	HsdM N-terminal domain; Region: HsdM_N; pfam12161
298386005548	N-6 DNA Methylase; Region: N6_Mtase; pfam02384
298386005549	Methyltransferase domain; Region: Methyltransf_26; pfam13659
298386005550	Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096
298386005551	Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958
298386005552	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
298386005553	ATP binding site [chemical binding]; other site
298386005554	putative Mg++ binding site [ion binding]; other site
298386005555	DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061
298386005556	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
298386005557	ATP binding site [chemical binding]; other site
298386005558	putative Mg++ binding site [ion binding]; other site
298386005559	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
298386005560	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298386005561	non-specific DNA binding site [nucleotide binding]; other site
298386005562	salt bridge; other site
298386005563	sequence-specific DNA binding site [nucleotide binding]; other site
298386005564	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
298386005565	active site
298386005566	catalytic residues [active]
298386005567	Int/Topo IB signature motif; other site
298386005568	DNA binding site [nucleotide binding]
298386005569	DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182
298386005570	active site
298386005571	catalytic residues [active]
298386005572	DNA binding site [nucleotide binding]
298386005573	Int/Topo IB signature motif; other site
298386005574	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386005575	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4688
298386005576	helicase, putative, RecD/TraA family; Region: recD_rel; TIGR01448
298386005577	AAA domain; Region: AAA_30; pfam13604
298386005578	Family description; Region: UvrD_C_2; pfam13538
298386005579	T5orf172 domain; Region: T5orf172; pfam10544
298386005580	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386005581	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
298386005582	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
298386005583	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
298386005584	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
298386005585	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
298386005586	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386005587	Restriction endonuclease; Region: Mrr_cat; pfam04471
298386005588	AAA ATPase domain; Region: AAA_16; pfam13191
298386005589	PAS domain; Region: PAS_9; pfam13426
298386005590	Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086
298386005591	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298386005592	dimer interface [polypeptide binding]; other site
298386005593	phosphorylation site [posttranslational modification]
298386005594	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386005595	ATP binding site [chemical binding]; other site
298386005596	Mg2+ binding site [ion binding]; other site
298386005597	G-X-G motif; other site
298386005598	Response regulator receiver domain; Region: Response_reg; pfam00072
298386005599	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386005600	active site
298386005601	phosphorylation site [posttranslational modification]
298386005602	intermolecular recognition site; other site
298386005603	dimerization interface [polypeptide binding]; other site
298386005604	Uncharacterized conserved protein [Function unknown]; Region: COG3287
298386005605	FIST N domain; Region: FIST; pfam08495
298386005606	FIST C domain; Region: FIST_C; pfam10442
298386005607	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298386005608	oxidoreductase; Validated; Region: PRK05717
298386005609	NAD(P) binding site [chemical binding]; other site
298386005610	active site
298386005611	Cytochrome cbb3 oxidase subunit I.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction...; Region: cbb3_Oxidase_I; cd01661
298386005612	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
298386005613	Low-spin heme binding site [chemical binding]; other site
298386005614	Putative water exit pathway; other site
298386005615	Binuclear center (active site) [active]
298386005616	Putative proton exit pathway; other site
298386005617	Cbb3-type cytochrome oxidase, cytochrome c subunit [Energy production and conversion]; Region: CcoO; COG2993
298386005618	cbb3-type cytochrome c oxidase subunit II; Provisional; Region: PRK14487
298386005619	Cytochrome cbb oxidase CcoQ.  Cytochrome cbb3 oxidase, the terminal oxidase in the respiratory chains of proteobacteria, is a multi-chain transmembrane protein located in the cell membrane. Like other cytochrome oxidases, it catalyzes the reduction of O2...; Region: cbb3_Oxidase_CcoQ; cd01324
298386005620	cytochrome c oxidase, cbb3-type, subunit III; Region: ccoP; TIGR00782
298386005621	cytochrome c-550; Provisional; Region: psbV; cl17239
298386005622	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
298386005623	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
298386005624	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3198
298386005625	FixH; Region: FixH; pfam05751
298386005626	Putative metal-binding domain of cation transport ATPase; Region: ATPase-cat_bd; pfam12156
298386005627	Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217
298386005628	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
298386005629	metal-binding site [ion binding]
298386005630	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
298386005631	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
298386005632	Family description; Region: DsbD_2; pfam13386
298386005633	fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161
298386005634	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
298386005635	ligand binding site [chemical binding]; other site
298386005636	flexible hinge region; other site
298386005637	helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092
298386005638	putative switch regulator; other site
298386005639	non-specific DNA interactions [nucleotide binding]; other site
298386005640	DNA binding site [nucleotide binding]
298386005641	sequence specific DNA binding site [nucleotide binding]; other site
298386005642	putative cAMP binding site [chemical binding]; other site
298386005643	universal stress protein UspE; Provisional; Region: PRK11175
298386005644	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
298386005645	Ligand Binding Site [chemical binding]; other site
298386005646	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
298386005647	Ligand Binding Site [chemical binding]; other site
298386005648	tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696
298386005649	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_II; cd01993
298386005650	Ligand Binding Site [chemical binding]; other site
298386005651	D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793
298386005652	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
298386005653	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
298386005654	Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317
298386005655	Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460
298386005656	active site
298386005657	Zn binding site [ion binding]; other site
298386005658	RES domain; Region: RES; smart00953
298386005659	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
298386005660	Cation efflux family; Region: Cation_efflux; pfam01545
298386005661	peptidase T; Region: peptidase-T; TIGR01882
298386005662	M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892
298386005663	metal binding site [ion binding]; metal-binding site
298386005664	dimer interface [polypeptide binding]; other site
298386005665	Protein of unknown function (DUF2987); Region: DUF2987; pfam11205
298386005666	Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; Region: Glucosaminidase; cl17361
298386005667	Predicted integral membrane protein (DUF2189); Region: DUF2189; cl02291
298386005668	putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452
298386005669	ATP-binding cassette domain of the polyamine transporter; Region: ABC_PotA_N; cd03300
298386005670	Walker A/P-loop; other site
298386005671	ATP binding site [chemical binding]; other site
298386005672	Q-loop/lid; other site
298386005673	ABC transporter signature motif; other site
298386005674	Walker B; other site
298386005675	D-loop; other site
298386005676	H-loop/switch region; other site
298386005677	TOBE domain; Region: TOBE_2; pfam08402
298386005678	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
298386005679	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386005680	dimer interface [polypeptide binding]; other site
298386005681	conserved gate region; other site
298386005682	putative PBP binding loops; other site
298386005683	ABC-ATPase subunit interface; other site
298386005684	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
298386005685	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386005686	dimer interface [polypeptide binding]; other site
298386005687	conserved gate region; other site
298386005688	putative PBP binding loops; other site
298386005689	ABC-ATPase subunit interface; other site
298386005690	spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501
298386005691	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
298386005692	spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501
298386005693	Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343
298386005694	Transposase IS200 like; Region: Y1_Tnp; pfam01797
298386005695	NAD-dependent deacetylase; Provisional; Region: PRK00481
298386005696	SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412
298386005697	NAD+ binding site [chemical binding]; other site
298386005698	substrate binding site [chemical binding]; other site
298386005699	Zn binding site [ion binding]; other site
298386005700	Cytochrome b subunit of formate dehydrogenase [Energy production and conversion]; Region: FdnI; COG2864
298386005701	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
298386005702	Fe-S-cluster-containing hydrogenase components 1 [Energy production and conversion]; Region: HybA; COG0437
298386005703	4Fe-4S binding domain; Region: Fer4; cl02805
298386005704	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752
298386005705	[4Fe-4S] binding site [ion binding]; other site
298386005706	molybdopterin cofactor binding site; other site
298386005707	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
298386005708	Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792
298386005709	molybdopterin cofactor binding site; other site
298386005710	formate dehydrogenase region TAT target; Region: formate_TAT; TIGR02811
298386005711	Nitrate reductase delta subunit; Region: Nitrate_red_del; pfam02613
298386005712	Ferredoxin [Energy production and conversion]; Region: COG1146
298386005713	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
298386005714	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
298386005715	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
298386005716	Protein of unknown function (DUF3306); Region: DUF3306; pfam11748
298386005717	Protein of unknown function (DUF3305); Region: DUF3305; pfam11749
298386005718	FdhD/NarQ family; Region: FdhD-NarQ; pfam02634
298386005719	Helix-turn-helix domain; Region: HTH_17; pfam12728
298386005720	PBP superfamily domain; Region: PBP_like; pfam12727
298386005721	short chain dehydrogenase; Provisional; Region: PRK07201
298386005722	Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263
298386005723	putative NAD(P) binding site [chemical binding]; other site
298386005724	active site
298386005725	putative substrate binding site [chemical binding]; other site
298386005726	classical (c) SDRs; Region: SDR_c; cd05233
298386005727	NAD(P) binding site [chemical binding]; other site
298386005728	active site
298386005729	Protein of unknown function (DUF2505); Region: DUF2505; pfam10698
298386005730	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298386005731	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298386005732	Bacterial transcriptional repressor; Region: TetR; pfam13972
298386005733	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
298386005734	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
298386005735	D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768
298386005736	Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693
298386005737	RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782
298386005738	RNA/DNA hybrid binding site [nucleotide binding]; other site
298386005739	active site
298386005740	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
298386005741	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
298386005742	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863
298386005743	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863
298386005744	Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; pfam09650
298386005745	Lecithin retinol acyltransferase; Region: LRAT; pfam04970
298386005746	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
298386005747	N-acetyl-D-glucosamine binding site [chemical binding]; other site
298386005748	catalytic residue [active]
298386005749	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
298386005750	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386005751	Major Facilitator Superfamily; Region: MFS_1; pfam07690
298386005752	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298386005753	putative substrate translocation pore; other site
298386005754	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
298386005755	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298386005756	dimer interface [polypeptide binding]; other site
298386005757	phosphorylation site [posttranslational modification]
298386005758	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386005759	ATP binding site [chemical binding]; other site
298386005760	Mg2+ binding site [ion binding]; other site
298386005761	G-X-G motif; other site
298386005762	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
298386005763	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386005764	active site
298386005765	phosphorylation site [posttranslational modification]
298386005766	intermolecular recognition site; other site
298386005767	dimerization interface [polypeptide binding]; other site
298386005768	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298386005769	Walker A motif; other site
298386005770	ATP binding site [chemical binding]; other site
298386005771	Walker B motif; other site
298386005772	arginine finger; other site
298386005773	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
298386005774	ABC-type tungstate transport system, permease component [Coenzyme metabolism]; Region: TupB; COG2998
298386005775	PBP superfamily domain; Region: PBP_like_2; pfam12849
298386005776	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386005777	dimer interface [polypeptide binding]; other site
298386005778	conserved gate region; other site
298386005779	putative PBP binding loops; other site
298386005780	ABC-ATPase subunit interface; other site
298386005781	ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122
298386005782	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298386005783	Walker A/P-loop; other site
298386005784	ATP binding site [chemical binding]; other site
298386005785	Q-loop/lid; other site
298386005786	ABC transporter signature motif; other site
298386005787	Walker B; other site
298386005788	D-loop; other site
298386005789	H-loop/switch region; other site
298386005790	molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317
298386005791	MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503
298386005792	GTP binding site; other site
298386005793	putative bifunctional molybdopterin-guanine dinucleotide biosynthesis protein MobB/MoeA; Provisional; Region: PRK14491
298386005794	Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116
298386005795	Walker A motif; other site
298386005796	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
298386005797	dimer interface [polypeptide binding]; other site
298386005798	putative functional site; other site
298386005799	putative MPT binding site; other site
298386005800	Protein of unknown function (DUF3581); Region: DUF3581; pfam12119
298386005801	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386005802	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386005803	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
298386005804	dimerization interface [polypeptide binding]; other site
298386005805	Protein of unknown function (DUF1611); Region: DUF1611; pfam07755
298386005806	L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129
298386005807	L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319
298386005808	active site
298386005809	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
298386005810	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386005811	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
298386005812	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
298386005813	PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610
298386005814	active site
298386005815	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
298386005816	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200
298386005817	Predicted metal-binding protein [General function prediction only]; Region: COG3019
298386005818	Protein of unknown function (DUF2786); Region: DUF2786; pfam10979
298386005819	inosine/guanosine kinase; Provisional; Region: PRK15074
298386005820	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
298386005821	substrate binding site [chemical binding]; other site
298386005822	ATP binding site [chemical binding]; other site
298386005823	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
298386005824	DNA-binding site [nucleotide binding]; DNA binding site
298386005825	RNA-binding motif; other site
298386005826	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
298386005827	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
298386005828	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386005829	active site
298386005830	phosphorylation site [posttranslational modification]
298386005831	intermolecular recognition site; other site
298386005832	dimerization interface [polypeptide binding]; other site
298386005833	Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418
298386005834	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
298386005835	Zn2+ binding site [ion binding]; other site
298386005836	Mg2+ binding site [ion binding]; other site
298386005837	elongation factor P; Provisional; Region: PRK04542
298386005838	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
298386005839	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
298386005840	RNA binding site [nucleotide binding]; other site
298386005841	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
298386005842	RNA binding site [nucleotide binding]; other site
298386005843	HD domain; Region: HD_3; pfam13023
298386005844	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298386005845	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
298386005846	Surface antigen; Region: Bac_surface_Ag; pfam01103
298386005847	carboxy-terminal protease; Provisional; Region: PRK11186
298386005848	PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988
298386005849	protein binding site [polypeptide binding]; other site
298386005850	C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560
298386005851	Catalytic dyad [active]
298386005852	C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818
298386005853	ProP expression regulator; Provisional; Region: PRK04950
298386005854	ProQ/FINO family; Region: ProQ; pfam04352
298386005855	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
298386005856	GAF domain; Region: GAF_2; pfam13185
298386005857	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
298386005858	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
298386005859	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298386005860	Walker A/P-loop; other site
298386005861	ATP binding site [chemical binding]; other site
298386005862	Q-loop/lid; other site
298386005863	ABC transporter signature motif; other site
298386005864	Walker B; other site
298386005865	D-loop; other site
298386005866	H-loop/switch region; other site
298386005867	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
298386005868	Paraquat-inducible protein A; Region: PqiA; pfam04403
298386005869	Paraquat-inducible protein A; Region: PqiA; pfam04403
298386005870	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
298386005871	mce related protein; Region: MCE; pfam02470
298386005872	mce related protein; Region: MCE; pfam02470
298386005873	mce related protein; Region: MCE; pfam02470
298386005874	mce related protein; Region: MCE; pfam02470
298386005875	Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008
298386005876	mce related protein; Region: MCE; pfam02470
298386005877	mce related protein; Region: MCE; pfam02470
298386005878	rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933
298386005879	NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446
298386005880	pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636
298386005881	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
298386005882	guanine deaminase; Provisional; Region: PRK09228
298386005883	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
298386005884	active site
298386005885	xanthine permease; Region: pbuX; TIGR03173
298386005886	putative hypoxanthine oxidase; Provisional; Region: PRK09800
298386005887	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
298386005888	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315
298386005889	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
298386005890	probable selenate reductase, FAD-binding subunit; Region: Se_sel_red_FAD; TIGR03312
298386005891	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
298386005892	BCCT family transporter; Region: BCCT; pfam02028
298386005893	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
298386005894	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
298386005895	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298386005896	cobalt transport protein ATP-binding subunit; Region: cbiO; TIGR01166
298386005897	Walker A/P-loop; other site
298386005898	ATP binding site [chemical binding]; other site
298386005899	Q-loop/lid; other site
298386005900	ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221
298386005901	ABC transporter signature motif; other site
298386005902	Walker B; other site
298386005903	D-loop; other site
298386005904	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386005905	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298386005906	Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221
298386005907	NAD(P) binding site [chemical binding]; other site
298386005908	active site
298386005909	Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319
298386005910	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092
298386005911	Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080
298386005912	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
298386005913	Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529
298386005914	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
298386005915	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
298386005916	putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314
298386005917	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
298386005918	active site
298386005919	putative substrate binding pocket [chemical binding]; other site
298386005920	putative selenate reductase subunit YgfK; Provisional; Region: PRK09853
298386005921	TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186
298386005922	phosphate binding site [ion binding]; other site
298386005923	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
298386005924	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
298386005925	Protein of unknown function (DUF3297); Region: DUF3297; pfam11730
298386005926	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
298386005927	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
298386005928	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
298386005929	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cl09940
298386005930	RNA binding surface [nucleotide binding]; other site
298386005931	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
298386005932	active site
298386005933	uracil binding [chemical binding]; other site
298386005934	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298386005935	Coenzyme A binding pocket [chemical binding]; other site
298386005936	DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863
298386005937	DNA methylase; Region: N6_N4_Mtase; pfam01555
298386005938	topology modulation protein; Reviewed; Region: PRK08118
298386005939	AAA domain; Region: AAA_17; pfam13207
298386005940	The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cl00320
298386005941	putative tRNA-binding site [nucleotide binding]; other site
298386005942	RDD family; Region: RDD; pfam06271
298386005943	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386005944	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386005945	azoreductase; Reviewed; Region: PRK00170
298386005946	MltA-interacting protein MipA; Region: MipA; cl01504
298386005947	hypothetical protein; Provisional; Region: PRK05423
298386005948	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
298386005949	DNA-binding site [nucleotide binding]; DNA binding site
298386005950	RNA-binding motif; other site
298386005951	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
298386005952	DNA-binding site [nucleotide binding]; DNA binding site
298386005953	RNA-binding motif; other site
298386005954	D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372
298386005955	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
298386005956	ATP-grasp domain; Region: ATP-grasp_4; cl17255
298386005957	LysE type translocator; Region: LysE; cl00565
298386005958	Protein of unknown function (DUF1706); Region: DUF1706; pfam08020
298386005959	Uncharacterized homolog of gamma-carboxymuconolactone decarboxylase subunit [Function unknown]; Region: COG0599
298386005960	Cache domain; Region: Cache_1; pfam02743
298386005961	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
298386005962	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298386005963	dimerization interface [polypeptide binding]; other site
298386005964	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298386005965	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298386005966	metal binding site [ion binding]; metal-binding site
298386005967	active site
298386005968	I-site; other site
298386005969	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
298386005970	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298386005971	Coenzyme A binding pocket [chemical binding]; other site
298386005972	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386005973	Flavodoxin-like fold; Region: Flavodoxin_2; pfam02525
298386005974	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
298386005975	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
298386005976	DNA binding residues [nucleotide binding]
298386005977	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
298386005978	Transposase IS200 like; Region: Y1_Tnp; pfam01797
298386005979	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
298386005980	Flagellin N-methylase; Region: FliB; cl00497
298386005981	SnoaL-like domain; Region: SnoaL_2; pfam12680
298386005982	Domain of unknown function (DUF4116); Region: DUF4116; pfam13475
298386005983	Domain of unknown function (DUF4116); Region: DUF4116; pfam13475
298386005984	Domain of unknown function (DUF4116); Region: DUF4116; pfam13475
298386005985	Domain of unknown function (DUF4116); Region: DUF4116; pfam13475
298386005986	Domain of unknown function (DUF4116); Region: DUF4116; pfam13475
298386005987	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
298386005988	active site
298386005989	phosphorylation site [posttranslational modification]
298386005990	intermolecular recognition site; other site
298386005991	dimerization interface [polypeptide binding]; other site
298386005992	Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975
298386005993	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
298386005994	XdhC Rossmann domain; Region: XdhC_C; pfam13478
298386005995	selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309
298386005996	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
298386005997	probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172
298386005998	GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182
298386005999	Ligand binding site; other site
298386006000	metal-binding site
298386006001	pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176
298386006002	Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034
298386006003	dimer interface [polypeptide binding]; other site
298386006004	PYR/PP interface [polypeptide binding]; other site
298386006005	TPP binding site [chemical binding]; other site
298386006006	substrate binding site [chemical binding]; other site
298386006007	Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014
298386006008	Domain of unknown function; Region: EKR; pfam10371
298386006009	4Fe-4S binding domain; Region: Fer4_6; pfam12837
298386006010	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
298386006011	Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377
298386006012	TPP-binding site [chemical binding]; other site
298386006013	dimer interface [polypeptide binding]; other site
298386006014	putative glutamate synthase (NADPH) small subunit; Provisional; Region: PRK12771
298386006015	Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912
298386006016	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
298386006017	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
298386006018	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
298386006019	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
298386006020	putative substrate binding site [chemical binding]; other site
298386006021	nucleotide binding site [chemical binding]; other site
298386006022	nucleotide binding site [chemical binding]; other site
298386006023	homodimer interface [polypeptide binding]; other site
298386006024	phenylhydantoinase; Validated; Region: PRK08323
298386006025	D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314
298386006026	tetramer interface [polypeptide binding]; other site
298386006027	active site
298386006028	peptidase; Reviewed; Region: PRK13004
298386006029	M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649
298386006030	putative metal binding site [ion binding]; other site
298386006031	putative dimer interface [polypeptide binding]; other site
298386006032	Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171
298386006033	Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640
298386006034	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
298386006035	catalytic residue [active]
298386006036	aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200
298386006037	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
298386006038	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
298386006039	Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829
298386006040	GAF domain; Region: GAF; cl17456
298386006041	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298386006042	Walker A motif; other site
298386006043	ATP binding site [chemical binding]; other site
298386006044	Walker B motif; other site
298386006045	arginine finger; other site
298386006046	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
298386006047	malate dehydrogenase; Provisional; Region: PRK13529
298386006048	Malic enzyme, N-terminal domain; Region: malic; pfam00390
298386006049	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
298386006050	NAD(P) binding site [chemical binding]; other site
298386006051	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
298386006052	putative active site [active]
298386006053	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
298386006054	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
298386006055	transmembrane helices; other site
298386006056	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
298386006057	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
298386006058	3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK12879
298386006059	Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830
298386006060	dimer interface [polypeptide binding]; other site
298386006061	active site
298386006062	CoA binding pocket [chemical binding]; other site
298386006063	integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718
298386006064	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298386006065	dimerization interface [polypeptide binding]; other site
298386006066	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
298386006067	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
298386006068	dimer interface [polypeptide binding]; other site
298386006069	putative CheW interface [polypeptide binding]; other site
298386006070	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2989
298386006071	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
298386006072	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
298386006073	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
298386006074	Putative hemolysin [General function prediction only]; Region: Hlx; COG3042
298386006075	Domain of unknown function (DUF333); Region: DUF333; pfam03891
298386006076	hypothetical protein; Provisional; Region: PRK10977
298386006077	glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041
298386006078	anaerobic ribonucleotide reductase-activating protein; Provisional; Region: nrdG; cl15804
298386006079	4Fe-4S binding domain; Region: Fer4; cl02805
298386006080	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
298386006081	FeS/SAM binding site; other site
298386006082	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386006083	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386006084	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
298386006085	substrate binding pocket [chemical binding]; other site
298386006086	dimerization interface [polypeptide binding]; other site
298386006087	GTP cyclohydrolase I; Provisional; Region: folE; PRK09347
298386006088	active site
298386006089	molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680
298386006090	MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887
298386006091	dimer interface [polypeptide binding]; other site
298386006092	putative functional site; other site
298386006093	putative MPT binding site; other site
298386006094	molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690
298386006095	ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757
298386006096	ATP binding site [chemical binding]; other site
298386006097	substrate interface [chemical binding]; other site
298386006098	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
298386006099	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
298386006100	Nucleoside recognition; Region: Gate; pfam07670
298386006101	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
298386006102	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
298386006103	PGAP1-like protein; Region: PGAP1; pfam07819
298386006104	oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104
298386006105	The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504
298386006106	peptide binding site [polypeptide binding]; other site
298386006107	Predicted RNA-bindining protein (contains S1 and HTH domains) [General function prediction only]; Region: COG2996
298386006108	S1 domain; Region: S1_2; pfam13509
298386006109	S1 domain; Region: S1_2; pfam13509
298386006110	Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316
298386006111	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
298386006112	Protein of unknown function (DUF2860); Region: DUF2860; pfam11059
298386006113	Cache domain; Region: Cache_1; pfam02743
298386006114	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
298386006115	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298386006116	dimerization interface [polypeptide binding]; other site
298386006117	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
298386006118	dimer interface [polypeptide binding]; other site
298386006119	putative CheW interface [polypeptide binding]; other site
298386006120	hypothetical protein; Validated; Region: PRK00029
298386006121	Uncharacterized conserved protein [Function unknown]; Region: COG0397
298386006122	Predicted O-acyltransferase [General function prediction only]; Region: COG3274
298386006123	Acyltransferase family; Region: Acyl_transf_3; pfam01757
298386006124	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
298386006125	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756
298386006126	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
298386006127	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666
298386006128	Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740
298386006129	DNA-J related protein; Region: DNAJ_related; pfam12339
298386006130	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
298386006131	HSP70 interaction site [polypeptide binding]; other site
298386006132	Pirin-related protein [General function prediction only]; Region: COG1741
298386006133	Pirin; Region: Pirin; pfam02678
298386006134	Pirin C-terminal cupin domain; Region: Pirin_C; pfam05726
298386006135	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
298386006136	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
298386006137	putative acyl-acceptor binding pocket; other site
298386006138	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
298386006139	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
298386006140	Nitrate reductase cytochrome c-type subunit (NapB); Region: NapB; pfam03892
298386006141	nitrate reductase catalytic subunit; Provisional; Region: PRK13532
298386006142	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
298386006143	[4Fe-4S] binding site [ion binding]; other site
298386006144	molybdopterin cofactor binding site; other site
298386006145	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
298386006146	molybdopterin cofactor binding site; other site
298386006147	Uncharacterized protein conserved in bacteria (DUF2131); Region: DUF2131; pfam09904
298386006148	Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160
298386006149	Peptidase family M50; Region: Peptidase_M50; pfam02163
298386006150	active site
298386006151	putative substrate binding region [chemical binding]; other site
298386006152	hypothetical protein; Provisional; Region: PRK11295
298386006153	active site
298386006154	Domain of unknown function (DUF2760); Region: DUF2760; pfam10816
298386006155	Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443
298386006156	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
298386006157	nucleotide binding site [chemical binding]; other site
298386006158	putative NEF/HSP70 interaction site [polypeptide binding]; other site
298386006159	SBD interface [polypeptide binding]; other site
298386006160	Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170
298386006161	nucleotide binding site [chemical binding]; other site
298386006162	putative NEF/HSP70 interaction site [polypeptide binding]; other site
298386006163	SBD interface [polypeptide binding]; other site
298386006164	DNA-K related protein; Region: DUF3731; pfam12531
298386006165	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
298386006166	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
298386006167	Walker A/P-loop; other site
298386006168	ATP binding site [chemical binding]; other site
298386006169	Q-loop/lid; other site
298386006170	ABC transporter signature motif; other site
298386006171	Walker B; other site
298386006172	D-loop; other site
298386006173	H-loop/switch region; other site
298386006174	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298386006175	DNA-binding site [nucleotide binding]; DNA binding site
298386006176	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
298386006177	Transposase; Region: HTH_Tnp_1; cl17663
298386006178	Transposase; Region: HTH_Tnp_1; cl17663
298386006179	Transposase IS200 like; Region: Y1_Tnp; pfam01797
298386006180	Transposase IS200 like; Region: Y1_Tnp; pfam01797
298386006181	Homeodomain-like domain; Region: HTH_32; pfam13565
298386006182	Integrase core domain; Region: rve; pfam00665
298386006183	Integrase core domain; Region: rve_3; pfam13683
298386006184	Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far.  This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases).  Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062
298386006185	B2 nucleotide binding pocket [chemical binding]; other site
298386006186	CAS motifs; other site
298386006187	active site
298386006188	B1 nucleotide binding pocket [chemical binding]; other site
298386006189	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
298386006190	amino acid carrier protein; Region: agcS; TIGR00835
298386006191	LysE type translocator; Region: LysE; cl00565
298386006192	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
298386006193	active site
298386006194	P-loop; other site
298386006195	phosphorylation site [posttranslational modification]
298386006196	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386006197	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
298386006198	active site
298386006199	phosphorylation site [posttranslational modification]
298386006200	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
298386006201	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
298386006202	active site
298386006203	P-loop; other site
298386006204	phosphorylation site [posttranslational modification]
298386006205	Cytochrome C' Region: Cytochrom_C_2; pfam01322
298386006206	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
298386006207	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
298386006208	MarR family; Region: MarR; pfam01047
298386006209	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
298386006210	active site
298386006211	catalytic residues [active]
298386006212	metal binding site [ion binding]; metal-binding site
298386006213	nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651
298386006214	active site
298386006215	tetramer interface [polypeptide binding]; other site
298386006216	WYL domain; Region: WYL; pfam13280
298386006217	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
298386006218	beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009
298386006219	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
298386006220	active site
298386006221	motif I; other site
298386006222	motif II; other site
298386006223	Yip1 domain; Region: Yip1; pfam04893
298386006224	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
298386006225	arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124
298386006226	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298386006227	Walker A/P-loop; other site
298386006228	ATP binding site [chemical binding]; other site
298386006229	Q-loop/lid; other site
298386006230	ABC transporter signature motif; other site
298386006231	Walker B; other site
298386006232	D-loop; other site
298386006233	H-loop/switch region; other site
298386006234	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
298386006235	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
298386006236	substrate binding pocket [chemical binding]; other site
298386006237	membrane-bound complex binding site; other site
298386006238	hinge residues; other site
298386006239	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
298386006240	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386006241	dimer interface [polypeptide binding]; other site
298386006242	conserved gate region; other site
298386006243	putative PBP binding loops; other site
298386006244	ABC-ATPase subunit interface; other site
298386006245	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
298386006246	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386006247	dimer interface [polypeptide binding]; other site
298386006248	conserved gate region; other site
298386006249	putative PBP binding loops; other site
298386006250	ABC-ATPase subunit interface; other site
298386006251	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
298386006252	dimerization interface [polypeptide binding]; other site
298386006253	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
298386006254	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
298386006255	dimer interface [polypeptide binding]; other site
298386006256	putative CheW interface [polypeptide binding]; other site
298386006257	DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727
298386006258	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
298386006259	DNA binding site [nucleotide binding]
298386006260	domain linker motif; other site
298386006261	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
298386006262	dimerization interface (closed form) [polypeptide binding]; other site
298386006263	ligand binding site [chemical binding]; other site
298386006264	galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019
298386006265	active site
298386006266	catalytic residues [active]
298386006267	galactokinase; Provisional; Region: PRK05101
298386006268	Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509
298386006269	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
298386006270	galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720
298386006271	Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608
298386006272	dimer interface [polypeptide binding]; other site
298386006273	active site
298386006274	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
298386006275	UDP-glucose 4-epimerase; Region: PLN02240
298386006276	NAD binding site [chemical binding]; other site
298386006277	homodimer interface [polypeptide binding]; other site
298386006278	active site
298386006279	substrate binding site [chemical binding]; other site
298386006280	DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339
298386006281	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
298386006282	DNA binding site [nucleotide binding]
298386006283	domain linker motif; other site
298386006284	Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544
298386006285	putative dimerization interface [polypeptide binding]; other site
298386006286	putative ligand binding site [chemical binding]; other site
298386006287	cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340
298386006288	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
298386006289	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
298386006290	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
298386006291	Beta galactosidase small chain; Region: Bgal_small_N; smart01038
298386006292	cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202
298386006293	inner membrane transporter YjeM; Provisional; Region: PRK15238
298386006294	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
298386006295	putative active site [active]
298386006296	heme pocket [chemical binding]; other site
298386006297	PAS domain; Region: PAS_9; pfam13426
298386006298	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
298386006299	putative active site [active]
298386006300	heme pocket [chemical binding]; other site
298386006301	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298386006302	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298386006303	metal binding site [ion binding]; metal-binding site
298386006304	active site
298386006305	I-site; other site
298386006306	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
298386006307	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
298386006308	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
298386006309	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
298386006310	P-loop; other site
298386006311	Magnesium ion binding site [ion binding]; other site
298386006312	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
298386006313	Magnesium ion binding site [ion binding]; other site
298386006314	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
298386006315	Transposase; Region: HTH_Tnp_1; cl17663
298386006316	Transposase; Region: HTH_Tnp_1; cl17663
298386006317	Winged helix-turn helix; Region: HTH_29; pfam13551
298386006318	Homeodomain-like domain; Region: HTH_32; pfam13565
298386006319	Integrase core domain; Region: rve; pfam00665
298386006320	Integrase core domain; Region: rve_3; pfam13683
298386006321	Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugZ; COG0748
298386006322	heme utilization protein HutZ; Region: heme_HutZ; TIGR04110
298386006323	putative heme utilization carrier protein HutX; Region: HutX; TIGR04108
298386006324	coproporphyrinogen III oxidase; Provisional; Region: PRK09058
298386006325	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
298386006326	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
298386006327	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
298386006328	Biopolymer transport protein ExbD/TolR; Region: ExbD; cl00537
298386006329	Periplasmic binding protein; Region: Peripla_BP_2; pfam01497
298386006330	Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+.  Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262
298386006331	intersubunit interface [polypeptide binding]; other site
298386006332	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
298386006333	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
298386006334	ABC-ATPase subunit  interface; other site
298386006335	dimer interface [polypeptide binding]; other site
298386006336	putative PBP binding regions; other site
298386006337	hemin importer ATP-binding subunit; Provisional; Region: hmuV; PRK13548
298386006338	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
298386006339	Walker A/P-loop; other site
298386006340	ATP binding site [chemical binding]; other site
298386006341	Q-loop/lid; other site
298386006342	ABC transporter signature motif; other site
298386006343	Walker B; other site
298386006344	D-loop; other site
298386006345	H-loop/switch region; other site
298386006346	DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703
298386006347	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
298386006348	DNA binding site [nucleotide binding]
298386006349	domain linker motif; other site
298386006350	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
298386006351	dimerization interface [polypeptide binding]; other site
298386006352	ligand binding site [chemical binding]; other site
298386006353	TfoX N-terminal domain; Region: TfoX_N; pfam04993
298386006354	TfoX C-terminal domain; Region: TfoX_C; pfam04994
298386006355	Uncharacterized conserved protein [Function unknown]; Region: COG2128
298386006356	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
298386006357	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
298386006358	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
298386006359	mercuric reductase; Validated; Region: PRK06370
298386006360	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
298386006361	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
298386006362	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
298386006363	hypothetical protein; Provisional; Region: PRK11622
298386006364	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134
298386006365	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135
298386006366	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386006367	dimer interface [polypeptide binding]; other site
298386006368	conserved gate region; other site
298386006369	putative PBP binding loops; other site
298386006370	ABC-ATPase subunit interface; other site
298386006371	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386006372	dimer interface [polypeptide binding]; other site
298386006373	conserved gate region; other site
298386006374	putative PBP binding loops; other site
298386006375	ABC-ATPase subunit interface; other site
298386006376	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136
298386006377	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298386006378	Walker A/P-loop; other site
298386006379	ATP binding site [chemical binding]; other site
298386006380	Q-loop/lid; other site
298386006381	ABC transporter signature motif; other site
298386006382	Walker B; other site
298386006383	D-loop; other site
298386006384	H-loop/switch region; other site
298386006385	Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558
298386006386	Arginate lyase and other MDR family members; Region: AL_MDR; cd08252
298386006387	zinc-binding alcohol dehydrogenase family protein; Region: adh_fam_1; TIGR02817
298386006388	putative NAD(P) binding site [chemical binding]; other site
298386006389	dimer interface [polypeptide binding]; other site
298386006390	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386006391	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386006392	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
298386006393	putative effector binding pocket; other site
298386006394	dimerization interface [polypeptide binding]; other site
298386006395	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
298386006396	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386006397	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
298386006398	dimerization interface [polypeptide binding]; other site
298386006399	putative transporter; Provisional; Region: PRK11043
298386006400	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298386006401	putative substrate translocation pore; other site
298386006402	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
298386006403	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
298386006404	substrate binding pocket [chemical binding]; other site
298386006405	membrane-bound complex binding site; other site
298386006406	hinge residues; other site
298386006407	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386006408	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298386006409	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298386006410	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
298386006411	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
298386006412	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
298386006413	HlyD family secretion protein; Region: HlyD_3; pfam13437
298386006414	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
298386006415	Transposase IS200 like; Region: Y1_Tnp; pfam01797
298386006416	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
298386006417	DnaJ domain or J-domain.  DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257
298386006418	HSP70 interaction site [polypeptide binding]; other site
298386006419	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736
298386006420	active site
298386006421	phosphorylation site [posttranslational modification]
298386006422	intermolecular recognition site; other site
298386006423	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
298386006424	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298386006425	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298386006426	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
298386006427	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
298386006428	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
298386006429	Predicted phosphatases [General function prediction only]; Region: Gph; COG0546
298386006430	High potential iron-sulfur protein; Region: HIPIP; pfam01355
298386006431	putative chaperone; Provisional; Region: PRK11678
298386006432	Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231
298386006433	nucleotide binding site [chemical binding]; other site
298386006434	putative NEF/HSP70 interaction site [polypeptide binding]; other site
298386006435	SBD interface [polypeptide binding]; other site
298386006436	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
298386006437	catalytic residues [active]
298386006438	hinge region; other site
298386006439	alpha helical domain; other site
298386006440	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
298386006441	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
298386006442	trimer interface [polypeptide binding]; other site
298386006443	eyelet of channel; other site
298386006444	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
298386006445	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
298386006446	eyelet of channel; other site
298386006447	trimer interface [polypeptide binding]; other site
298386006448	Ribonucleotide reductase, all-alpha domain; Region: Ribonuc_red_lgN; pfam00317
298386006449	ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; Region: NrdJ_Z; TIGR02504
298386006450	Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888
298386006451	active site
298386006452	dimer interface [polypeptide binding]; other site
298386006453	effector binding site; other site
298386006454	Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939
298386006455	TSCPD domain; Region: TSCPD; pfam12637
298386006456	putative transporter; Validated; Region: PRK03818
298386006457	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
298386006458	TrkA-C domain; Region: TrkA_C; pfam02080
298386006459	TrkA-C domain; Region: TrkA_C; pfam02080
298386006460	AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625
298386006461	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
298386006462	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298386006463	dimerization interface [polypeptide binding]; other site
298386006464	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
298386006465	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
298386006466	dimer interface [polypeptide binding]; other site
298386006467	putative CheW interface [polypeptide binding]; other site
298386006468	Transcriptional regulators [Transcription]; Region: PurR; COG1609
298386006469	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
298386006470	DNA binding site [nucleotide binding]
298386006471	Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270
298386006472	ligand binding site [chemical binding]; other site
298386006473	dimerization interface (closed form) [polypeptide binding]; other site
298386006474	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
298386006475	Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168
298386006476	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
298386006477	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298386006478	homodimer interface [polypeptide binding]; other site
298386006479	catalytic residue [active]
298386006480	DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023
298386006481	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
298386006482	catalytic residues [active]
298386006483	vitamin B12-transporter ATPase; Provisional; Region: PRK03695
298386006484	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
298386006485	Walker A/P-loop; other site
298386006486	ATP binding site [chemical binding]; other site
298386006487	Q-loop/lid; other site
298386006488	ABC transporter signature motif; other site
298386006489	Walker B; other site
298386006490	D-loop; other site
298386006491	H-loop/switch region; other site
298386006492	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
298386006493	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
298386006494	dimer interface [polypeptide binding]; other site
298386006495	ABC-ATPase subunit  interface; other site
298386006496	putative PBP binding regions; other site
298386006497	Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855
298386006498	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
298386006499	putative active site [active]
298386006500	Zn binding site [ion binding]; other site
298386006501	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
298386006502	IHF dimer interface [polypeptide binding]; other site
298386006503	IHF - DNA interface [nucleotide binding]; other site
298386006504	phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629
298386006505	tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain.  PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796
298386006506	putative tRNA-binding site [nucleotide binding]; other site
298386006507	B3/4 domain; Region: B3_4; pfam03483
298386006508	tRNA synthetase B5 domain; Region: B5; smart00874
298386006509	Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA,  PheRS is an...; Region: PheRS_beta_core; cd00769
298386006510	dimer interface [polypeptide binding]; other site
298386006511	motif 1; other site
298386006512	motif 3; other site
298386006513	motif 2; other site
298386006514	Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147
298386006515	phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488
298386006516	Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912
298386006517	Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496
298386006518	dimer interface [polypeptide binding]; other site
298386006519	motif 1; other site
298386006520	active site
298386006521	motif 2; other site
298386006522	motif 3; other site
298386006523	Ribosomal protein L20; Region: Ribosomal_L20; cd07026
298386006524	23S rRNA binding site [nucleotide binding]; other site
298386006525	L21 binding site [polypeptide binding]; other site
298386006526	L13 binding site [polypeptide binding]; other site
298386006527	translation initiation factor IF-3; Reviewed; Region: infC; PRK00028
298386006528	Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198
298386006529	Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707
298386006530	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
298386006531	motif 3; other site
298386006532	ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860
298386006533	anticodon binding site; other site
298386006534	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
298386006535	motif 2; other site
298386006536	TGS _ThrRS_N:  ThrRS (threonyl-tRNA Synthetase)  is a class II tRNA synthetase that couples threonine to its cognate tRNA.  In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667
298386006537	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973
298386006538	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
298386006539	motif 1; other site
298386006540	Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309
298386006541	Leucine rich repeat; Region: LRR_8; pfam13855
298386006542	Substrate binding site [chemical binding]; other site
298386006543	Leucine rich repeat; Region: LRR_8; pfam13855
298386006544	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
298386006545	active site
298386006546	ATP binding site [chemical binding]; other site
298386006547	substrate binding site [chemical binding]; other site
298386006548	activation loop (A-loop); other site
298386006549	ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552
298386006550	histidine utilization repressor, proteobacterial; Region: his_ut_repres; TIGR02018
298386006551	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298386006552	DNA-binding site [nucleotide binding]; DNA binding site
298386006553	UTRA domain; Region: UTRA; pfam07702
298386006554	imidazolonepropionase; Validated; Region: PRK09356
298386006555	Imidazolonepropionase/imidazolone-5-propionate hydrolase (Imidazolone-5PH) catalyzes the third step in the histidine degradation pathway, the hydrolysis of (S)-3-(5-oxo-4,5-dihydro-3H-imidazol-4-yl)propanoate to N-formimidoyl-L-glutamate. In bacteria; Region: Imidazolone-5PH; cd01296
298386006556	active site
298386006557	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
298386006558	putative active site [active]
298386006559	putative metal binding site [ion binding]; other site
298386006560	urocanate hydratase; Provisional; Region: PRK05414
298386006561	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
298386006562	active sites [active]
298386006563	tetramer interface [polypeptide binding]; other site
298386006564	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
298386006565	Phosphotransferase enzyme family; Region: APH; pfam01636
298386006566	active site
298386006567	ATP binding site [chemical binding]; other site
298386006568	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270
298386006569	substrate binding site [chemical binding]; other site
298386006570	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
298386006571	motif II; other site
298386006572	riboflavin synthase subunit alpha; Provisional; Region: PRK13020
298386006573	Lumazine binding domain; Region: Lum_binding; pfam00677
298386006574	Lumazine binding domain; Region: Lum_binding; pfam00677
298386006575	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298386006576	dimerization interface [polypeptide binding]; other site
298386006577	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298386006578	dimer interface [polypeptide binding]; other site
298386006579	phosphorylation site [posttranslational modification]
298386006580	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386006581	ATP binding site [chemical binding]; other site
298386006582	Mg2+ binding site [ion binding]; other site
298386006583	G-X-G motif; other site
298386006584	osmolarity response regulator; Provisional; Region: ompR; PRK09468
298386006585	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386006586	active site
298386006587	phosphorylation site [posttranslational modification]
298386006588	intermolecular recognition site; other site
298386006589	dimerization interface [polypeptide binding]; other site
298386006590	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298386006591	DNA binding site [nucleotide binding]
298386006592	multidrug efflux protein; Reviewed; Region: PRK01766
298386006593	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
298386006594	cation binding site [ion binding]; other site
298386006595	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
298386006596	Glycoside hydrolase family 19 chitinase domain. Chitinases are enzymes that catalyze the hydrolysis of the beta-1,4-N-acetyl-D-glucosamine linkages in chitin polymers. Family 19 chitinases are found primarily in plants (classes I, III, and IV), but some...; Region: chitinase_glyco_hydro_19; cd00325
298386006597	putative sugar binding site [chemical binding]; other site
298386006598	catalytic residues [active]
298386006599	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
298386006600	aromatic chitin/cellulose binding site residues [chemical binding]; other site
298386006601	Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150
298386006602	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
298386006603	Sporulation related domain; Region: SPOR; pfam05036
298386006604	Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689
298386006605	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
298386006606	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
298386006607	substrate binding pocket [chemical binding]; other site
298386006608	membrane-bound complex binding site; other site
298386006609	hinge residues; other site
298386006610	ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597
298386006611	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386006612	conserved gate region; other site
298386006613	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386006614	putative PBP binding loops; other site
298386006615	dimer interface [polypeptide binding]; other site
298386006616	ABC-ATPase subunit interface; other site
298386006617	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
298386006618	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386006619	dimer interface [polypeptide binding]; other site
298386006620	conserved gate region; other site
298386006621	putative PBP binding loops; other site
298386006622	ABC-ATPase subunit interface; other site
298386006623	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
298386006624	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
298386006625	Walker A/P-loop; other site
298386006626	ATP binding site [chemical binding]; other site
298386006627	Q-loop/lid; other site
298386006628	ABC transporter signature motif; other site
298386006629	Walker B; other site
298386006630	D-loop; other site
298386006631	H-loop/switch region; other site
298386006632	Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670
298386006633	YccA-like proteins; Region: YccA_like; cd10433
298386006634	Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920
298386006635	sulfur relay protein, TusE/DsrC/DsvC family; Region: dsrC_tusE_dsvC; TIGR03342
298386006636	acylphosphatase; Provisional; Region: PRK14426
298386006637	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
298386006638	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
298386006639	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
298386006640	dimer interface [polypeptide binding]; other site
298386006641	putative CheW interface [polypeptide binding]; other site
298386006642	23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128
298386006643	Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359
298386006644	Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572
298386006645	putative RNA binding site [nucleotide binding]; other site
298386006646	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298386006647	S-adenosylmethionine binding site [chemical binding]; other site
298386006648	hypothetical protein; Provisional; Region: PRK10621
298386006649	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
298386006650	hypothetical protein; Provisional; Region: PRK03641
298386006651	Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; pfam09829
298386006652	Predicted signal transduction protein containing EAL and modified HD-GYP domains [Signal transduction mechanisms]; Region: COG3434
298386006653	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290
298386006654	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
298386006655	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
298386006656	aromatic chitin/cellulose binding site residues [chemical binding]; other site
298386006657	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
298386006658	active site
298386006659	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
298386006660	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
298386006661	Chitinase C; Region: ChiC; pfam06483
298386006662	Cellulose-binding domain, chitinase and related proteins; Region: CBD_like; cd12204
298386006663	aromatic chitin/cellulose binding site residues [chemical binding]; other site
298386006664	ligand binding site [chemical binding]; other site
298386006665	L,D-transpeptidase catalytic domain; Region: YkuD_2; pfam13645
298386006666	Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686
298386006667	Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305
298386006668	hexamer interface [polypeptide binding]; other site
298386006669	ligand binding site [chemical binding]; other site
298386006670	putative active site [active]
298386006671	NAD(P) binding site [chemical binding]; other site
298386006672	Phosphocholine cytidylyltransferases catalyze the synthesis of CDP-choline; Region: PC_cytidylyltransferase; cd02523
298386006673	active site
298386006674	metal-binding site
298386006675	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066
298386006676	Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075
298386006677	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
298386006678	catalytic residue [active]
298386006679	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
298386006680	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
298386006681	motif II; other site
298386006682	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298386006683	putative substrate translocation pore; other site
298386006684	Major Facilitator Superfamily; Region: MFS_1; pfam07690
298386006685	glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK08955
298386006686	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
298386006687	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
298386006688	Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053
298386006689	Low molecular weight phosphatase family; Region: LMWPc; cl00105
298386006690	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
298386006691	dimerization interface [polypeptide binding]; other site
298386006692	putative DNA binding site [nucleotide binding]; other site
298386006693	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
298386006694	putative Zn2+ binding site [ion binding]; other site
298386006695	PGAP1-like protein; Region: PGAP1; pfam07819
298386006696	choline dehydrogenase; Validated; Region: PRK02106
298386006697	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
298386006698	short chain dehydrogenase; Provisional; Region: PRK07201
298386006699	Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263
298386006700	putative NAD(P) binding site [chemical binding]; other site
298386006701	active site
298386006702	putative substrate binding site [chemical binding]; other site
298386006703	classical (c) SDRs; Region: SDR_c; cd05233
298386006704	NAD(P) binding site [chemical binding]; other site
298386006705	active site
298386006706	Acyl CoA binding protein; Region: ACBP; pfam00887
298386006707	acyl-CoA binding pocket [chemical binding]; other site
298386006708	CoA binding site [chemical binding]; other site
298386006709	Wax ester synthase-like Acyl-CoA acyltransferase domain; Region: WES_acyltransf; pfam03007
298386006710	acyltransferase, WS/DGAT/MGAT; Region: acyl_WS_DGAT; TIGR02946
298386006711	Poly(hydroxyalcanoate) granule associated protein (phasin); Region: Phasin; cl07863
298386006712	Acetyl-CoA hydrolase [Energy production and conversion]; Region: ACH1; COG0427
298386006713	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
298386006714	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386006715	Response regulator receiver domain; Region: Response_reg; pfam00072
298386006716	active site
298386006717	phosphorylation site [posttranslational modification]
298386006718	intermolecular recognition site; other site
298386006719	dimerization interface [polypeptide binding]; other site
298386006720	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298386006721	TPR motif; other site
298386006722	Tetratricopeptide repeat; Region: TPR_16; pfam13432
298386006723	binding surface
298386006724	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386006725	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386006726	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
298386006727	putative effector binding pocket; other site
298386006728	dimerization interface [polypeptide binding]; other site
298386006729	L-lactate permease; Region: Lactate_perm; cl00701
298386006730	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
298386006731	D-lactate dehydrogenase; Provisional; Region: PRK11183
298386006732	FAD binding domain; Region: FAD_binding_4; pfam01565
298386006733	D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330
298386006734	carboxynorspermidine decarboxylase; Region: nspC; TIGR01047
298386006735	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Carboxynorspermidine Decarboxylase; Region: PLPDE_III_CANSDC; cd06829
298386006736	dimer interface [polypeptide binding]; other site
298386006737	active site
298386006738	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
298386006739	catalytic residues [active]
298386006740	substrate binding site [chemical binding]; other site
298386006741	Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748
298386006742	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
298386006743	NAD(P) binding pocket [chemical binding]; other site
298386006744	diaminobutyrate--2-oxoglutarate aminotransferase; Provisional; Region: PRK06938
298386006745	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
298386006746	inhibitor-cofactor binding pocket; inhibition site
298386006747	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298386006748	catalytic residue [active]
298386006749	DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450
298386006750	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298386006751	catalytic residue [active]
298386006752	Phosphotransferase system, EIIC; Region: PTS_EIIC_2; pfam13303
298386006753	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; cl17425
298386006754	CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453
298386006755	excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558
298386006756	Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434
298386006757	GIY-YIG motif/motif A; other site
298386006758	active site
298386006759	catalytic site [active]
298386006760	putative DNA binding site [nucleotide binding]; other site
298386006761	metal binding site [ion binding]; metal-binding site
298386006762	UvrB/uvrC motif; Region: UVR; pfam02151
298386006763	UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459
298386006764	Helix-hairpin-helix motif; Region: HHH; pfam00633
298386006765	response regulator; Provisional; Region: PRK09483
298386006766	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386006767	active site
298386006768	phosphorylation site [posttranslational modification]
298386006769	intermolecular recognition site; other site
298386006770	dimerization interface [polypeptide binding]; other site
298386006771	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298386006772	DNA binding residues [nucleotide binding]
298386006773	dimerization interface [polypeptide binding]; other site
298386006774	hypothetical protein; Provisional; Region: PRK13661
298386006775	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
298386006776	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
298386006777	Walker A/P-loop; other site
298386006778	ATP binding site [chemical binding]; other site
298386006779	Q-loop/lid; other site
298386006780	ABC transporter signature motif; other site
298386006781	Walker B; other site
298386006782	D-loop; other site
298386006783	H-loop/switch region; other site
298386006784	ATP-binding cassette cobalt transporter; Region: DUF3744; pfam12558
298386006785	First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225
298386006786	Walker A/P-loop; other site
298386006787	ATP binding site [chemical binding]; other site
298386006788	Q-loop/lid; other site
298386006789	ABC transporter signature motif; other site
298386006790	Walker B; other site
298386006791	D-loop; other site
298386006792	H-loop/switch region; other site
298386006793	ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619
298386006794	Transcriptional regulators [Transcription]; Region: FadR; COG2186
298386006795	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298386006796	DNA-binding site [nucleotide binding]; DNA binding site
298386006797	FCD domain; Region: FCD; pfam07729
298386006798	xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963
298386006799	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
298386006800	catalytic loop [active]
298386006801	iron binding site [ion binding]; other site
298386006802	[2Fe-2S] binding domain; Region: Fer2_2; pfam01799
298386006803	CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450
298386006804	xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965
298386006805	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008
298386006806	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
298386006807	XdhC and CoxI family; Region: XdhC_CoxI; pfam02625
298386006808	xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964
298386006809	XdhC Rossmann domain; Region: XdhC_C; pfam13478
298386006810	guanine deaminase; Provisional; Region: PRK09228
298386006811	Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303
298386006812	active site
298386006813	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
298386006814	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
298386006815	replication protein; Provisional; Region: PRK13742
298386006816	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
298386006817	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_17; cd08503
298386006818	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601
298386006819	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386006820	dimer interface [polypeptide binding]; other site
298386006821	conserved gate region; other site
298386006822	putative PBP binding loops; other site
298386006823	ABC-ATPase subunit interface; other site
298386006824	ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173
298386006825	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386006826	dimer interface [polypeptide binding]; other site
298386006827	conserved gate region; other site
298386006828	putative PBP binding loops; other site
298386006829	ABC-ATPase subunit interface; other site
298386006830	ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123
298386006831	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
298386006832	Walker A/P-loop; other site
298386006833	ATP binding site [chemical binding]; other site
298386006834	Q-loop/lid; other site
298386006835	ABC transporter signature motif; other site
298386006836	Walker B; other site
298386006837	D-loop; other site
298386006838	H-loop/switch region; other site
298386006839	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
298386006840	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
298386006841	Walker A/P-loop; other site
298386006842	ATP binding site [chemical binding]; other site
298386006843	Q-loop/lid; other site
298386006844	ABC transporter signature motif; other site
298386006845	Walker B; other site
298386006846	D-loop; other site
298386006847	H-loop/switch region; other site
298386006848	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
298386006849	The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346
298386006850	trimer interface; other site
298386006851	sugar binding site [chemical binding]; other site
298386006852	Maltose operon periplasmic protein precursor (MalM); Region: MalM; cl11647
298386006853	Predicted membrane protein [Function unknown]; Region: COG3748
298386006854	Protein of unknown function (DUF989); Region: DUF989; pfam06181
298386006855	Cytochrome c; Region: Cytochrom_C; pfam00034
298386006856	Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194
298386006857	ureidoglycolate hydrolase; Provisional; Region: PRK03606
298386006858	allantoicase; Provisional; Region: PRK13257
298386006859	Allantoicase repeat; Region: Allantoicase; pfam03561
298386006860	Allantoicase repeat; Region: Allantoicase; pfam03561
298386006861	OHCU decarboxylase; Region: UHCUDC; TIGR03164
298386006862	putative urate catabolism protein; Region: uraD_N-term-dom; TIGR03212
298386006863	Catalytic domain of bacterial PuuE allantoinases, Schizosaccharomyces pombe chitin deacetylase 1 (SpCDA1), and similar proteins; Region: CE4_PuuE_SpCDA1; cd10977
298386006864	active site
298386006865	catalytic site [active]
298386006866	tetramer interface [polypeptide binding]; other site
298386006867	HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822
298386006868	active site
298386006869	homotetramer interface [polypeptide binding]; other site
298386006870	Xanthine/uracil/vitamin C permease [Nucleotide transport and    metabolism]; Region: COG2252
298386006871	Sulfate transporter family; Region: Sulfate_transp; pfam00916
298386006872	xanthine permease; Region: pbuX; TIGR03173
298386006873	hydroxydechloroatrazine ethylaminohydrolase; Reviewed; Region: PRK08203
298386006874	TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298
298386006875	active site
298386006876	putative substrate binding pocket [chemical binding]; other site
298386006877	pyrimidine utilization regulatory protein R; Region: RutR; TIGR03613
298386006878	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298386006879	YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362
298386006880	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
298386006881	active site
298386006882	nucleophile elbow; other site
298386006883	Transposase IS200 like; Region: Y1_Tnp; pfam01797
298386006884	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
298386006885	Putative glycerate kinase [Carbohydrate transport and metabolism]; Region: GckA; COG2379
298386006886	Domain of unknown function (DUF4147); Region: DUF4147; pfam13660
298386006887	MOFRL family; Region: MOFRL; pfam05161
298386006888	tartronate semialdehyde reductase; Provisional; Region: PRK15059
298386006889	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
298386006890	hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234
298386006891	glyoxylate carboligase; Provisional; Region: PRK11269
298386006892	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
298386006893	PYR/PP interface [polypeptide binding]; other site
298386006894	dimer interface [polypeptide binding]; other site
298386006895	TPP binding site [chemical binding]; other site
298386006896	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
298386006897	Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006
298386006898	TPP-binding site [chemical binding]; other site
298386006899	malate synthase A; Region: malate_syn_A; TIGR01344
298386006900	Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727
298386006901	active site
298386006902	Uncharacterized protein, possibly involved in utilization of glycolate and propanediol [General function prediction only]; Region: GlcG; COG3193
298386006903	DctM-like transporters; Region: DctM; pfam06808
298386006904	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
298386006905	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
298386006906	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
298386006907	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
298386006908	Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731
298386006909	uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495
298386006910	Na binding site [ion binding]; other site
298386006911	N-acetylmannosamine kinase; Provisional; Region: PRK05082
298386006912	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
298386006913	nucleotide binding site [chemical binding]; other site
298386006914	N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729
298386006915	N-acetylmannosamine-6-phosphate 2-epimerase; Provisional; Region: PRK01130
298386006916	putative active site cavity [active]
298386006917	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
298386006918	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
298386006919	Protein of unknown function (DUF592); Region: DUF592; pfam04574
298386006920	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
298386006921	putative active site [active]
298386006922	Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329
298386006923	Class I aldolases; Region: Aldolase_Class_I; cl17187
298386006924	catalytic residue [active]
298386006925	Peptidase M66; Region: Peptidase_M66; pfam10462
298386006926	triphosphoribosyl-dephospho-CoA synthase CitG; Region: citrate_citG; TIGR03125
298386006927	holo-ACP synthase CitX; Region: citrate_citX; TIGR03124
298386006928	Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051
298386006929	Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336
298386006930	HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231
298386006931	Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053
298386006932	Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169
298386006933	putative active site [active]
298386006934	(T/H)XGH motif; other site
298386006935	2-hydroxycarboxylate transporter family; Region: 2HCT; pfam03390
298386006936	oxaloacetate decarboxylase; Provisional; Region: PRK14040
298386006937	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
298386006938	active site
298386006939	catalytic residues [active]
298386006940	metal binding site [ion binding]; metal-binding site
298386006941	homodimer binding site [polypeptide binding]; other site
298386006942	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
298386006943	carboxyltransferase (CT) interaction site; other site
298386006944	biotinylation site [posttranslational modification]; other site
298386006945	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
298386006946	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
298386006947	PAS domain; Region: PAS; smart00091
298386006948	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386006949	ATP binding site [chemical binding]; other site
298386006950	Mg2+ binding site [ion binding]; other site
298386006951	G-X-G motif; other site
298386006952	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
298386006953	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386006954	active site
298386006955	phosphorylation site [posttranslational modification]
298386006956	intermolecular recognition site; other site
298386006957	dimerization interface [polypeptide binding]; other site
298386006958	Transcriptional regulator; Region: CitT; pfam12431
298386006959	Protein of unknown function (DUF3775); Region: DUF3775; pfam12616
298386006960	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
298386006961	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
298386006962	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
298386006963	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
298386006964	dimer interface [polypeptide binding]; other site
298386006965	putative CheW interface [polypeptide binding]; other site
298386006966	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
298386006967	EamA-like transporter family; Region: EamA; pfam00892
298386006968	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
298386006969	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298386006970	DNA-binding site [nucleotide binding]; DNA binding site
298386006971	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
298386006972	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298386006973	homodimer interface [polypeptide binding]; other site
298386006974	catalytic residue [active]
298386006975	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298386006976	TPR motif; other site
298386006977	TPR repeat; Region: TPR_11; pfam13414
298386006978	binding surface
298386006979	Transposase IS200 like; Region: Y1_Tnp; pfam01797
298386006980	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
298386006981	ABC-2 type transporter; Region: ABC2_membrane; pfam01061
298386006982	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
298386006983	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
298386006984	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
298386006985	Walker A/P-loop; other site
298386006986	ATP binding site [chemical binding]; other site
298386006987	Q-loop/lid; other site
298386006988	ABC transporter signature motif; other site
298386006989	Walker B; other site
298386006990	D-loop; other site
298386006991	H-loop/switch region; other site
298386006992	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
298386006993	HlyD family secretion protein; Region: HlyD_3; pfam13437
298386006994	Uncharacterized FAD-dependent dehydrogenases [General function prediction only]; Region: COG2509
298386006995	Flagellin N-methylase; Region: FliB; cl00497
298386006996	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
298386006997	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
298386006998	HlyD family secretion protein; Region: HlyD_3; pfam13437
298386006999	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386007000	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386007001	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
298386007002	putative effector binding pocket; other site
298386007003	dimerization interface [polypeptide binding]; other site
298386007004	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298386007005	putative substrate translocation pore; other site
298386007006	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
298386007007	heat shock protein HtpX; Provisional; Region: PRK05457
298386007008	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
298386007009	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
298386007010	Sulfate transporter family; Region: Sulfate_transp; pfam00916
298386007011	Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659
298386007012	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
298386007013	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
298386007014	Ligand Binding Site [chemical binding]; other site
298386007015	AAA domain; Region: AAA_26; pfam13500
298386007016	dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090
298386007017	biotin biosynthesis protein BioC; Region: BioC; TIGR02072
298386007018	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173
298386007019	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298386007020	S-adenosylmethionine binding site [chemical binding]; other site
298386007021	KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454
298386007022	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
298386007023	substrate-cofactor binding pocket; other site
298386007024	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298386007025	catalytic residue [active]
298386007026	biotin synthase; Provisional; Region: PRK15108
298386007027	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
298386007028	FeS/SAM binding site; other site
298386007029	Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876
298386007030	adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986
298386007031	Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610
298386007032	inhibitor-cofactor binding pocket; inhibition site
298386007033	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298386007034	catalytic residue [active]
298386007035	ATP-dependent protease La (LON) domain; Region: LON; pfam02190
298386007036	Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940
298386007037	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
298386007038	nucleotide binding site [chemical binding]; other site
298386007039	Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602
298386007040	putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322
298386007041	asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932
298386007042	EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318
298386007043	putative dimer interface [polypeptide binding]; other site
298386007044	putative anticodon binding site; other site
298386007045	Asx tRNA synthetase (AspRS/AsnRS) class II core domain.  Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776
298386007046	homodimer interface [polypeptide binding]; other site
298386007047	motif 1; other site
298386007048	motif 2; other site
298386007049	active site
298386007050	motif 3; other site
298386007051	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
298386007052	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
298386007053	4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170
298386007054	substrate binding site [chemical binding]; other site
298386007055	multimerization interface [polypeptide binding]; other site
298386007056	ATP binding site [chemical binding]; other site
298386007057	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807
298386007058	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
298386007059	Protein of unknown function (DUF1456); Region: DUF1456; pfam07308
298386007060	enoyl-CoA hydratase; Provisional; Region: PRK06688
298386007061	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298386007062	substrate binding site [chemical binding]; other site
298386007063	oxyanion hole (OAH) forming residues; other site
298386007064	trimer interface [polypeptide binding]; other site
298386007065	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298386007066	Major Facilitator Superfamily; Region: MFS_1; pfam07690
298386007067	putative substrate translocation pore; other site
298386007068	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
298386007069	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
298386007070	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298386007071	homodimer interface [polypeptide binding]; other site
298386007072	catalytic residue [active]
298386007073	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cl17326
298386007074	Protein of unknown function (DUF2982); Region: DUF2982; pfam11201
298386007075	regulatory protein UhpC; Provisional; Region: PRK11663
298386007076	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298386007077	putative substrate translocation pore; other site
298386007078	sensory histidine kinase UhpB; Provisional; Region: PRK11644
298386007079	MASE1; Region: MASE1; pfam05231
298386007080	Histidine kinase; Region: HisKA_3; pfam07730
298386007081	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386007082	ATP binding site [chemical binding]; other site
298386007083	Mg2+ binding site [ion binding]; other site
298386007084	G-X-G motif; other site
298386007085	DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360
298386007086	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386007087	active site
298386007088	phosphorylation site [posttranslational modification]
298386007089	intermolecular recognition site; other site
298386007090	dimerization interface [polypeptide binding]; other site
298386007091	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298386007092	DNA binding residues [nucleotide binding]
298386007093	dimerization interface [polypeptide binding]; other site
298386007094	sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556
298386007095	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298386007096	putative substrate translocation pore; other site
298386007097	Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491
298386007098	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108
298386007099	Peptidase M15; Region: Peptidase_M15_3; cl01194
298386007100	murein L,D-transpeptidase; Provisional; Region: PRK10594
298386007101	Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471
298386007102	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
298386007103	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
298386007104	Transcriptional regulators [Transcription]; Region: MarR; COG1846
298386007105	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
298386007106	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386007107	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386007108	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
298386007109	dimerization interface [polypeptide binding]; other site
298386007110	hypothetical protein; Provisional; Region: PRK10621
298386007111	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
298386007112	cell density-dependent motility repressor; Provisional; Region: PRK10082
298386007113	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386007114	LysR substrate binding domain; Region: LysR_substrate; pfam03466
298386007115	Asp/Glu/Hydantoin racemase; Region: Asp_Glu_race; cl00518
298386007116	aspartate racemase; Region: asp_race; TIGR00035
298386007117	L-lactate permease; Region: Lactate_perm; cl00701
298386007118	L-lactate permease [Energy production and conversion]; Region: LldP; COG1620
298386007119	Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247
298386007120	Cysteine-rich domain; Region: CCG; pfam02754
298386007121	Cysteine-rich domain; Region: CCG; pfam02754
298386007122	Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139
298386007123	Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589
298386007124	Domain of unknown function (DUF3390); Region: DUF3390; pfam11870
298386007125	Uncharacterized conserved protein [Function unknown]; Region: COG1556
298386007126	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386007127	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386007128	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
298386007129	putative effector binding pocket; other site
298386007130	dimerization interface [polypeptide binding]; other site
298386007131	Truncated hemoglobins (trHbs) are a family of oxygen-binding heme proteins found in cyanobacteria, eubacteria, unicellular eukaryotes, and plants. The truncated hemoglobins have a characteristic two-over-two alpha helical folding pattern that is distinct...; Region: Trunc_globin; cd00454
298386007132	apolar tunnel; other site
298386007133	heme binding site [chemical binding]; other site
298386007134	dimerization interface [polypeptide binding]; other site
298386007135	trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102
298386007136	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
298386007137	molybdopterin cofactor binding site [chemical binding]; other site
298386007138	substrate binding site [chemical binding]; other site
298386007139	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
298386007140	molybdopterin cofactor binding site; other site
298386007141	periplasmic nitrate (or nitrite) reductase c-type cytochrome, NapC/NirT family; Region: napC_nirT; TIGR02161
298386007142	trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162
298386007143	Dihaem cytochrome c; Region: DHC; pfam09626
298386007144	putative peptidase; Provisional; Region: PRK11649
298386007145	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
298386007146	Peptidase family M23; Region: Peptidase_M23; pfam01551
298386007147	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
298386007148	ankyrin repeats;  ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204
298386007149	Ankyrin repeats (3 copies); Region: Ank_2; pfam12796
298386007150	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
298386007151	Transposase; Region: DEDD_Tnp_IS110; pfam01548
298386007152	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
298386007153	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
298386007154	Transposase; Region: HTH_Tnp_1; cl17663
298386007155	Transposase; Region: HTH_Tnp_1; cl17663
298386007156	Winged helix-turn helix; Region: HTH_29; pfam13551
298386007157	Homeodomain-like domain; Region: HTH_32; pfam13565
298386007158	Integrase core domain; Region: rve; pfam00665
298386007159	Integrase core domain; Region: rve_3; pfam13683
298386007160	Homeodomain-like domain; Region: HTH_23; pfam13384
298386007161	Winged helix-turn helix; Region: HTH_29; pfam13551
298386007162	Winged helix-turn helix; Region: HTH_33; pfam13592
298386007163	DDE superfamily endonuclease; Region: DDE_3; pfam13358
298386007164	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
298386007165	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
298386007166	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
298386007167	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
298386007168	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386007169	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
298386007170	cell division protein MukB; Provisional; Region: mukB; PRK04863
298386007171	P-loop containing region of AAA domain; Region: AAA_29; cl17516
298386007172	Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558
298386007173	condesin subunit E; Provisional; Region: PRK05256
298386007174	condesin subunit F; Provisional; Region: PRK05260
298386007175	2-polyprenyl-3-methyl-5-hydroxy-6-metoxy-1, 4-benzoquinol methylase [Coenzyme metabolism]; Region: UbiG; COG2227
298386007176	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298386007177	S-adenosylmethionine binding site [chemical binding]; other site
298386007178	Uncharacterized conserved protein [Function unknown]; Region: COG1434
298386007179	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
298386007180	putative active site [active]
298386007181	Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823
298386007182	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
298386007183	3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450
298386007184	CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517
298386007185	Ligand binding site; other site
298386007186	oligomer interface; other site
298386007187	Uncharacterized conserved protein [Function unknown]; Region: COG2835
298386007188	tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652
298386007189	Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663
298386007190	lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176
298386007191	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
298386007192	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
298386007193	Walker A/P-loop; other site
298386007194	ATP binding site [chemical binding]; other site
298386007195	Q-loop/lid; other site
298386007196	ABC transporter signature motif; other site
298386007197	Walker B; other site
298386007198	D-loop; other site
298386007199	H-loop/switch region; other site
298386007200	ComEC family competence protein; Provisional; Region: PRK11539
298386007201	Domain of unknown function (DUF4131); Region: DUF4131; pfam13567
298386007202	Competence protein; Region: Competence; pfam03772
298386007203	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
298386007204	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3216
298386007205	outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146
298386007206	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
298386007207	FtsX-like permease family; Region: FtsX; pfam02687
298386007208	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
298386007209	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
298386007210	Walker A/P-loop; other site
298386007211	ATP binding site [chemical binding]; other site
298386007212	Q-loop/lid; other site
298386007213	ABC transporter signature motif; other site
298386007214	Walker B; other site
298386007215	D-loop; other site
298386007216	H-loop/switch region; other site
298386007217	outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814
298386007218	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
298386007219	FtsX-like permease family; Region: FtsX; pfam02687
298386007220	transcription-repair coupling factor; Provisional; Region: PRK10689
298386007221	CarD-like/TRCF domain; Region: CarD_TRCF; smart01058
298386007222	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
298386007223	ATP binding site [chemical binding]; other site
298386007224	putative Mg++ binding site [ion binding]; other site
298386007225	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
298386007226	nucleotide binding region [chemical binding]; other site
298386007227	ATP-binding site [chemical binding]; other site
298386007228	This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982
298386007229	Protein of unknown function (DUF2803); Region: DUF2803; pfam10972
298386007230	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
298386007231	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
298386007232	FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545
298386007233	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
298386007234	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
298386007235	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
298386007236	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
298386007237	hypothetical protein; Provisional; Region: PRK04940
298386007238	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
298386007239	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
298386007240	thiamine kinase; Region: ycfN_thiK; TIGR02721
298386007241	active site
298386007242	substrate binding site [chemical binding]; other site
298386007243	ATP binding site [chemical binding]; other site
298386007244	uncharacterized proteobacterial lipoprotein; Region: lp_; TIGR02722
298386007245	Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633
298386007246	Putative periplasmic lipoprotein; Region: DUF1425; cd09030
298386007247	putative dimer interface [polypeptide binding]; other site
298386007248	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014
298386007249	Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276
298386007250	nucleotide binding site/active site [active]
298386007251	HIT family signature motif; other site
298386007252	catalytic residue [active]
298386007253	CHASE3 domain; Region: CHASE3; cl05000
298386007254	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
298386007255	HAMP domain; Region: HAMP; pfam00672
298386007256	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
298386007257	dimer interface [polypeptide binding]; other site
298386007258	putative CheW interface [polypeptide binding]; other site
298386007259	Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294
298386007260	active site
298386007261	substrate binding pocket [chemical binding]; other site
298386007262	dimer interface [polypeptide binding]; other site
298386007263	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
298386007264	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
298386007265	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
298386007266	HlyD family secretion protein; Region: HlyD_3; pfam13437
298386007267	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
298386007268	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
298386007269	HlyD family secretion protein; Region: HlyD_3; pfam13437
298386007270	putative fumarate hydratase; Provisional; Region: PRK15392
298386007271	Fumarate hydratase (Fumerase); Region: Fumerase; pfam05681
298386007272	Fumarase C-terminus; Region: Fumerase_C; pfam05683
298386007273	aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465
298386007274	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
298386007275	chorismate binding enzyme; Region: Chorismate_bind; cl10555
298386007276	Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426
298386007277	putative active site [active]
298386007278	putative CoA binding site [chemical binding]; other site
298386007279	nudix motif; other site
298386007280	metal binding site [ion binding]; metal-binding site
298386007281	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
298386007282	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
298386007283	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
298386007284	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
298386007285	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
298386007286	ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747
298386007287	GPR1/FUN34/yaaH family; Region: Grp1_Fun34_YaaH; cl00685
298386007288	This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146
298386007289	dimer interface [polypeptide binding]; other site
298386007290	FMN binding site [chemical binding]; other site
298386007291	NADPH bind site [chemical binding]; other site
298386007292	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
298386007293	Iron-containing alcohol dehydrogenases-like; Region: Fe-ADH2; cd08183
298386007294	putative active site [active]
298386007295	metal binding site [ion binding]; metal-binding site
298386007296	Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066
298386007297	GSH binding site [chemical binding]; other site
298386007298	catalytic residues [active]
298386007299	putative transporter; Provisional; Region: PRK04972
298386007300	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
298386007301	TrkA-C domain; Region: TrkA_C; pfam02080
298386007302	TrkA-C domain; Region: TrkA_C; pfam02080
298386007303	Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826
298386007304	DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816
298386007305	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386007306	active site
298386007307	phosphorylation site [posttranslational modification]
298386007308	intermolecular recognition site; other site
298386007309	dimerization interface [polypeptide binding]; other site
298386007310	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298386007311	DNA binding site [nucleotide binding]
298386007312	sensor protein PhoQ; Provisional; Region: PRK10815
298386007313	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386007314	ATP binding site [chemical binding]; other site
298386007315	Mg2+ binding site [ion binding]; other site
298386007316	G-X-G motif; other site
298386007317	trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656
298386007318	NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242
298386007319	Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241
298386007320	Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055
298386007321	acyl-CoA dehydrogenase; Reviewed; Region: PRK13026
298386007322	Acyl-CoA dehydrogenase; Region: ACAD; cl09933
298386007323	active site
298386007324	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
298386007325	hypothetical protein; Provisional; Region: PRK07338
298386007326	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
298386007327	metal binding site [ion binding]; metal-binding site
298386007328	dimer interface [polypeptide binding]; other site
298386007329	Transposase IS200 like; Region: Y1_Tnp; pfam01797
298386007330	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
298386007331	atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266
298386007332	putative NAD(P) binding site [chemical binding]; other site
298386007333	DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302
298386007334	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
298386007335	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
298386007336	putative active site [active]
298386007337	Pyruvate kinase (PK):  Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342
298386007338	pyruvate kinase; Provisional; Region: PRK05826
298386007339	domain interfaces; other site
298386007340	active site
298386007341	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
298386007342	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
298386007343	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
298386007344	6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870
298386007345	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
298386007346	DNA binding site [nucleotide binding]
298386007347	active site
298386007348	DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820
298386007349	N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877
298386007350	putative aromatic amino acid binding site; other site
298386007351	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298386007352	Walker A motif; other site
298386007353	ATP binding site [chemical binding]; other site
298386007354	Walker B motif; other site
298386007355	arginine finger; other site
298386007356	hypothetical protein; Provisional; Region: PRK05415
298386007357	Domain of unknown function (DUF697); Region: DUF697; cl12064
298386007358	YcjX-like family, DUF463; Region: DUF463; pfam04317
298386007359	PspC domain; Region: PspC; cl00864
298386007360	phage shock protein C; Region: phageshock_pspC; TIGR02978
298386007361	phage shock protein B; Provisional; Region: pspB; PRK09458
298386007362	phage shock protein A; Region: phageshock_pspA; TIGR02977
298386007363	psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974
298386007364	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298386007365	Walker A motif; other site
298386007366	ATP binding site [chemical binding]; other site
298386007367	Walker B motif; other site
298386007368	arginine finger; other site
298386007369	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
298386007370	ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747
298386007371	The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493
298386007372	peptide binding site [polypeptide binding]; other site
298386007373	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapB; COG4168
298386007374	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386007375	dimer interface [polypeptide binding]; other site
298386007376	conserved gate region; other site
298386007377	putative PBP binding loops; other site
298386007378	ABC-ATPase subunit interface; other site
298386007379	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SapC; COG4171
298386007380	N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911
298386007381	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386007382	dimer interface [polypeptide binding]; other site
298386007383	conserved gate region; other site
298386007384	ABC-ATPase subunit interface; other site
298386007385	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapD; COG4170
298386007386	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
298386007387	Walker A/P-loop; other site
298386007388	ATP binding site [chemical binding]; other site
298386007389	Q-loop/lid; other site
298386007390	ABC transporter signature motif; other site
298386007391	Walker B; other site
298386007392	D-loop; other site
298386007393	H-loop/switch region; other site
298386007394	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
298386007395	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SapF; COG4167
298386007396	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
298386007397	Walker A/P-loop; other site
298386007398	ATP binding site [chemical binding]; other site
298386007399	Q-loop/lid; other site
298386007400	ABC transporter signature motif; other site
298386007401	Walker B; other site
298386007402	D-loop; other site
298386007403	H-loop/switch region; other site
298386007404	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097
298386007405	Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725
298386007406	active site
298386007407	dimer interface [polypeptide binding]; other site
298386007408	tetratricopeptide repeat protein; Provisional; Region: PRK11788
298386007409	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
298386007410	TPR motif; other site
298386007411	binding surface
298386007412	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298386007413	binding surface
298386007414	TPR motif; other site
298386007415	Predicted membrane protein [Function unknown]; Region: COG3771
298386007416	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
298386007417	IHF dimer interface [polypeptide binding]; other site
298386007418	IHF - DNA interface [nucleotide binding]; other site
298386007419	30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299
298386007420	S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687
298386007421	RNA binding site [nucleotide binding]; other site
298386007422	S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465
298386007423	RNA binding site [nucleotide binding]; other site
298386007424	S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688
298386007425	RNA binding site [nucleotide binding]; other site
298386007426	S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689
298386007427	RNA binding site [nucleotide binding]; other site
298386007428	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
298386007429	RNA binding site [nucleotide binding]; other site
298386007430	S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691
298386007431	RNA binding site [nucleotide binding]; other site
298386007432	cytidylate kinase; Provisional; Region: cmk; PRK00023
298386007433	Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020
298386007434	CMP-binding site; other site
298386007435	The sites determining sugar specificity; other site
298386007436	3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427
298386007437	EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556
298386007438	hinge; other site
298386007439	active site
298386007440	Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT).  PSAT is active as...; Region: PSAT_like; cd00611
298386007441	homodimer interface [polypeptide binding]; other site
298386007442	substrate-cofactor binding pocket; other site
298386007443	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298386007444	catalytic residue [active]
298386007445	DNA gyrase subunit A; Validated; Region: PRK05560
298386007446	DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187
298386007447	CAP-like domain; other site
298386007448	active site
298386007449	primary dimer interface [polypeptide binding]; other site
298386007450	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
298386007451	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
298386007452	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
298386007453	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
298386007454	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
298386007455	DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989
298386007456	bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134
298386007457	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298386007458	S-adenosylmethionine binding site [chemical binding]; other site
298386007459	phosphoglycolate phosphatase; Provisional; Region: PRK13222
298386007460	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
298386007461	motif II; other site
298386007462	ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103
298386007463	ATP cone domain; Region: ATP-cone; pfam03477
298386007464	Class I ribonucleotide reductase; Region: RNR_I; cd01679
298386007465	active site
298386007466	dimer interface [polypeptide binding]; other site
298386007467	catalytic residues [active]
298386007468	effector binding site; other site
298386007469	R2 peptide binding site; other site
298386007470	Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049
298386007471	dimer interface [polypeptide binding]; other site
298386007472	putative radical transfer pathway; other site
298386007473	diiron center [ion binding]; other site
298386007474	tyrosyl radical; other site
298386007475	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
298386007476	Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633
298386007477	catalytic loop [active]
298386007478	iron binding site [ion binding]; other site
298386007479	Type III secretion system lipoprotein chaperone (YscW); Region: YscW; cl15825
298386007480	META domain; Region: META; pfam03724
298386007481	hypothetical protein; Provisional; Region: PRK03673
298386007482	Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885
298386007483	putative MPT binding site; other site
298386007484	Competence-damaged protein; Region: CinA; pfam02464
298386007485	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
298386007486	aromatic amino acid transport protein; Region: araaP; TIGR00837
298386007487	Domain of unknown function (DUF3943); Region: DUF3943; pfam13084
298386007488	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298386007489	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298386007490	metal binding site [ion binding]; metal-binding site
298386007491	active site
298386007492	I-site; other site
298386007493	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
298386007494	Sulfite exporter TauE/SafE; Region: TauE; pfam01925
298386007495	Methyltransferase domain; Region: Methyltransf_32; pfam13679
298386007496	transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681
298386007497	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386007498	The C-terminal substrate domain of LysR-type transcriptional regulators CysB-like contains type 2 periplasmic binding fold; Region: PBP2_CysB_like; cd08413
298386007499	substrate binding site [chemical binding]; other site
298386007500	dimerization interface [polypeptide binding]; other site
298386007501	MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910
298386007502	active site
298386007503	dinuclear metal binding site [ion binding]; other site
298386007504	dimerization interface [polypeptide binding]; other site
298386007505	transcriptional regulator CysB-like protein; Reviewed; Region: PRK12682
298386007506	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386007507	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
298386007508	dimerization interface [polypeptide binding]; other site
298386007509	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
298386007510	M20 Peptidase Aminoacylase 1 family; Region: M20_Acy1; cd03886
298386007511	metal binding site [ion binding]; metal-binding site
298386007512	dimer interface [polypeptide binding]; other site
298386007513	Protein of unknown function (DUF3100); Region: DUF3100; pfam11299
298386007514	DNA topoisomerase I subunit omega; Validated; Region: PRK07561
298386007515	TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I.   Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363
298386007516	active site
298386007517	interdomain interaction site; other site
298386007518	putative metal-binding site [ion binding]; other site
298386007519	nucleotide binding site [chemical binding]; other site
298386007520	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
298386007521	domain I; other site
298386007522	DNA binding groove [nucleotide binding]
298386007523	phosphate binding site [ion binding]; other site
298386007524	domain II; other site
298386007525	domain III; other site
298386007526	nucleotide binding site [chemical binding]; other site
298386007527	catalytic site [active]
298386007528	domain IV; other site
298386007529	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
298386007530	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
298386007531	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
298386007532	Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272
298386007533	hypothetical protein; Provisional; Region: PRK11037
298386007534	Protein of unknown function (DUF805); Region: DUF805; pfam05656
298386007535	Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496
298386007536	putative inner membrane peptidase; Provisional; Region: PRK11778
298386007537	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
298386007538	tandem repeat interface [polypeptide binding]; other site
298386007539	oligomer interface [polypeptide binding]; other site
298386007540	active site residues [active]
298386007541	putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945
298386007542	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298386007543	NAD(P) binding site [chemical binding]; other site
298386007544	active site
298386007545	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
298386007546	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
298386007547	RNA binding surface [nucleotide binding]; other site
298386007548	Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556
298386007549	probable active site [active]
298386007550	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
298386007551	Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613
298386007552	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
298386007553	active site
298386007554	Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438
298386007555	3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673
298386007556	3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225
298386007557	anthranilate synthase component I; Provisional; Region: PRK13564
298386007558	Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715
298386007559	chorismate binding enzyme; Region: Chorismate_bind; pfam00425
298386007560	Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743
298386007561	Glutamine amidotransferase class-I; Region: GATase; pfam00117
298386007562	glutamine binding [chemical binding]; other site
298386007563	catalytic triad [active]
298386007564	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
298386007565	anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188
298386007566	Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591
298386007567	bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427
298386007568	Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331
298386007569	active site
298386007570	ribulose/triose binding site [chemical binding]; other site
298386007571	phosphate binding site [ion binding]; other site
298386007572	substrate (anthranilate) binding pocket [chemical binding]; other site
298386007573	product (indole) binding pocket [chemical binding]; other site
298386007574	Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405
298386007575	active site
298386007576	tryptophan synthase, beta subunit; Region: trpB; TIGR00263
298386007577	Tryptophan synthase-beta:  Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446
298386007578	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298386007579	catalytic residue [active]
298386007580	tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200
298386007581	Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724
298386007582	substrate binding site [chemical binding]; other site
298386007583	active site
298386007584	catalytic residues [active]
298386007585	heterodimer interface [polypeptide binding]; other site
298386007586	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
298386007587	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
298386007588	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386007589	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386007590	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
298386007591	dimerization interface [polypeptide binding]; other site
298386007592	Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960
298386007593	Domains similar to fish antifreeze type III protein; Region: SAF; cl00555
298386007594	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
298386007595	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
298386007596	BON domain; Region: BON; pfam04972
298386007597	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
298386007598	AAA domain; Region: AAA_31; pfam13614
298386007599	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
298386007600	Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962
298386007601	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
298386007602	ATP binding site [chemical binding]; other site
298386007603	Walker A motif; other site
298386007604	hexamer interface [polypeptide binding]; other site
298386007605	Walker B motif; other site
298386007606	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
298386007607	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
298386007608	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
298386007609	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
298386007610	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429
298386007611	binding surface
298386007612	TPR motif; other site
298386007613	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298386007614	binding surface
298386007615	TPR motif; other site
298386007616	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
298386007617	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
298386007618	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
298386007619	flagellar motor protein MotS; Reviewed; Region: PRK06742
298386007620	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
298386007621	ligand binding site [chemical binding]; other site
298386007622	intracellular septation protein A; Reviewed; Region: PRK00259
298386007623	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
298386007624	YciI-like protein; Reviewed; Region: PRK11370
298386007625	S-adenosylmethionine-dependent methyltransferase; Region: Methyltrans_SAM; pfam10672
298386007626	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298386007627	S-adenosylmethionine binding site [chemical binding]; other site
298386007628	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
298386007629	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
298386007630	active site
298386007631	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
298386007632	Na2 binding site [ion binding]; other site
298386007633	putative substrate binding site 1 [chemical binding]; other site
298386007634	Na binding site 1 [ion binding]; other site
298386007635	putative substrate binding site 2 [chemical binding]; other site
298386007636	cardiolipin synthetase; Reviewed; Region: cls; PRK01642
298386007637	Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396
298386007638	Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152
298386007639	putative active site [active]
298386007640	catalytic site [active]
298386007641	Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158
298386007642	putative active site [active]
298386007643	catalytic site [active]
298386007644	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
298386007645	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298386007646	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298386007647	metal binding site [ion binding]; metal-binding site
298386007648	active site
298386007649	I-site; other site
298386007650	BCCT family transporter; Region: BCCT; pfam02028
298386007651	exonuclease, DNA polymerase III, epsilon subunit family; Region: dnaq; TIGR00573
298386007652	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
298386007653	active site
298386007654	catalytic site [active]
298386007655	substrate binding site [chemical binding]; other site
298386007656	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
298386007657	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
298386007658	ligand binding site [chemical binding]; other site
298386007659	flexible hinge region; other site
298386007660	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc2; cd04800
298386007661	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
298386007662	metal binding triad; other site
298386007663	putative alcohol dehydrogenase; Provisional; Region: PRK09860
298386007664	Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176
298386007665	dimer interface [polypeptide binding]; other site
298386007666	active site
298386007667	metal binding site [ion binding]; metal-binding site
298386007668	Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143
298386007669	active site
298386007670	Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220
298386007671	Catalytic domain of Protein Kinases; Region: PKc; cd00180
298386007672	active site
298386007673	ATP binding site [chemical binding]; other site
298386007674	substrate binding site [chemical binding]; other site
298386007675	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
298386007676	activation loop (A-loop); other site
298386007677	activation loop (A-loop); other site
298386007678	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298386007679	putative substrate translocation pore; other site
298386007680	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298386007681	Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529
298386007682	nitrite reductase subunit NirD; Provisional; Region: PRK14989
298386007683	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
298386007684	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
298386007685	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
298386007686	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
298386007687	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
298386007688	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
298386007689	Diphthamide biosynthesis methyltransferase [Translation, ribosomal structure and biogenesis]; Region: DPH5; COG1798
298386007690	active site
298386007691	SAM binding site [chemical binding]; other site
298386007692	homodimer interface [polypeptide binding]; other site
298386007693	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
298386007694	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
298386007695	[4Fe-4S] binding site [ion binding]; other site
298386007696	molybdopterin cofactor binding site; other site
298386007697	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
298386007698	molybdopterin cofactor binding site; other site
298386007699	BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324
298386007700	Esterases and lipases (includes fungal lipases, cholinesterases, etc.)  These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312
298386007701	Protein of unknown function (DUF2424); Region: DUF2424; pfam10340
298386007702	alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859
298386007703	trans-2-enoyl-CoA reductase; Provisional; Region: PRK13656
298386007704	NAD(P)H binding domain of trans-2-enoyl-CoA reductase; Region: Eno-Rase_NADH_b; pfam12242
298386007705	Trans-2-enoyl-CoA reductase catalytic region; Region: Enoyl_reductase; pfam12241
298386007706	Enoyl reductase FAD binding domain; Region: Eno-Rase_FAD_bd; pfam07055
298386007707	putative mechanosensitive channel protein; Provisional; Region: PRK10929
298386007708	Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794
298386007709	Mechanosensitive ion channel; Region: MS_channel; pfam00924
298386007710	tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617
298386007711	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
298386007712	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
298386007713	catalytic residue [active]
298386007714	Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316
298386007715	aromatic amino acid transport protein; Region: araaP; TIGR00837
298386007716	pyridoxamine kinase; Validated; Region: PRK05756
298386007717	Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate  (PLP), by catalyzing the phosphorylation of the precursor vitamin B6  in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173
298386007718	pyridoxal binding site [chemical binding]; other site
298386007719	dimer interface [polypeptide binding]; other site
298386007720	ATP binding site [chemical binding]; other site
298386007721	Protein of unknown function (DUF1144); Region: DUF1144; pfam06610
298386007722	deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926
298386007723	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
298386007724	Zn2+ binding site [ion binding]; other site
298386007725	Mg2+ binding site [ion binding]; other site
298386007726	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
298386007727	Predicted ATPase [General function prediction only]; Region: COG4637
298386007728	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298386007729	Walker A/P-loop; other site
298386007730	ATP binding site [chemical binding]; other site
298386007731	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298386007732	Walker B; other site
298386007733	D-loop; other site
298386007734	H-loop/switch region; other site
298386007735	chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168
298386007736	Predicted transcriptional regulator [Transcription]; Region: COG2378
298386007737	WYL domain; Region: WYL; pfam13280
298386007738	Uncharacterized protein family (UPF0149); Region: UPF0149; cl01173
298386007739	Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318
298386007740	bile acid transporter; Region: bass; TIGR00841
298386007741	Sodium Bile acid symporter family; Region: SBF; cl17470
298386007742	quinolinate synthetase; Provisional; Region: PRK09375
298386007743	tol-pal system protein YbgF; Provisional; Region: PRK10803
298386007744	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298386007745	binding surface
298386007746	TPR motif; other site
298386007747	peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802
298386007748	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
298386007749	ligand binding site [chemical binding]; other site
298386007750	translocation protein TolB; Provisional; Region: tolB; PRK04792
298386007751	TolB amino-terminal domain; Region: TolB_N; pfam04052
298386007752	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
298386007753	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
298386007754	WD40-like Beta Propeller Repeat; Region: PD40; pfam07676
298386007755	TolA protein; Region: tolA_full; TIGR02794
298386007756	TolA protein; Region: tolA_full; TIGR02794
298386007757	TolA C-terminal; Region: TolA; pfam06519
298386007758	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
298386007759	TolR protein; Region: tolR; TIGR02801
298386007760	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568
298386007761	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
298386007762	active site
298386007763	Cyd operon protein YbgE (Cyd_oper_YbgE); Region: Cyd_oper_YbgE; pfam09600
298386007764	Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039
298386007765	cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219
298386007766	Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322
298386007767	cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097
298386007768	Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562
298386007769	Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146
298386007770	active site pocket [active]
298386007771	oxyanion hole [active]
298386007772	catalytic triad [active]
298386007773	active site nucleophile [active]
298386007774	electron transport complex protein RsxA; Provisional; Region: PRK05151
298386007775	ferredoxin; Provisional; Region: PRK08764
298386007776	Putative Fe-S cluster; Region: FeS; pfam04060
298386007777	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
298386007778	Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656
298386007779	Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404
298386007780	SLBB domain; Region: SLBB; pfam10531
298386007781	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
298386007782	electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816
298386007783	electron transport complex protein RnfG; Validated; Region: PRK01908
298386007784	electron transport complex RsxE subunit; Provisional; Region: PRK12405
298386007785	endonuclease III; Provisional; Region: PRK10702
298386007786	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
298386007787	minor groove reading motif; other site
298386007788	helix-hairpin-helix signature motif; other site
298386007789	substrate binding pocket [chemical binding]; other site
298386007790	active site
298386007791	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
298386007792	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
298386007793	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298386007794	dimer interface [polypeptide binding]; other site
298386007795	active site
298386007796	glutathione binding site [chemical binding]; other site
298386007797	Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605
298386007798	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
298386007799	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
298386007800	Protein of unknown function (DUF2753); Region: DUF2753; pfam10952
298386007801	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
298386007802	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
298386007803	ligand binding site [chemical binding]; other site
298386007804	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
298386007805	DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134
298386007806	dimer interface [polypeptide binding]; other site
298386007807	catalytic site [active]
298386007808	putative active site [active]
298386007809	putative substrate binding site [chemical binding]; other site
298386007810	Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479
298386007811	Bacterial virulence factor lipase N-terminal; Region: Lipase_bact_N; pfam12262
298386007812	extracellular lipase, Pla-1/cef family; Region: lipase_Pla1_cef; TIGR03502
298386007813	peroxidase; Provisional; Region: PRK15000
298386007814	Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015
298386007815	dimer interface [polypeptide binding]; other site
298386007816	decamer (pentamer of dimers) interface [polypeptide binding]; other site
298386007817	catalytic triad [active]
298386007818	peroxidatic and resolving cysteines [active]
298386007819	Predicted permease [General function prediction only]; Region: COG2056
298386007820	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
298386007821	Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028
298386007822	putative GSH binding site [chemical binding]; other site
298386007823	catalytic residues [active]
298386007824	superoxide dismutase; Provisional; Region: PRK10543
298386007825	Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081
298386007826	Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777
298386007827	aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598
298386007828	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
298386007829	Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931
298386007830	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
298386007831	Nucleoside recognition; Region: Gate; pfam07670
298386007832	hypothetical protein; Provisional; Region: PRK10519
298386007833	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
298386007834	Peptidase family M20/M25/M40; Region: Peptidase_M20; pfam01546
298386007835	metal binding site [ion binding]; metal-binding site
298386007836	dimer interface [polypeptide binding]; other site
298386007837	Nitrous oxide-stimulated promoter; Region: YgbA_NO; cl08119
298386007838	Nucleoid-associated protein [General function prediction only]; Region: COG3081
298386007839	nucleoid-associated protein NdpA; Validated; Region: PRK00378
298386007840	Protein of unknown function (DUF1414); Region: DUF1414; cl01175
298386007841	Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083
298386007842	Domain of unknown function (DUF3413); Region: DUF3413; pfam11893
298386007843	Sulfatase; Region: Sulfatase; cl17466
298386007844	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298386007845	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298386007846	metal binding site [ion binding]; metal-binding site
298386007847	active site
298386007848	I-site; other site
298386007849	TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362
298386007850	DNA topoisomerase III; Provisional; Region: PRK07726
298386007851	active site
298386007852	putative interdomain interaction site [polypeptide binding]; other site
298386007853	putative metal-binding site [ion binding]; other site
298386007854	putative nucleotide binding site [chemical binding]; other site
298386007855	DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186
298386007856	domain I; other site
298386007857	DNA binding groove [nucleotide binding]
298386007858	phosphate binding site [ion binding]; other site
298386007859	domain II; other site
298386007860	domain III; other site
298386007861	nucleotide binding site [chemical binding]; other site
298386007862	catalytic site [active]
298386007863	domain IV; other site
298386007864	tRNA 2-selenouridine synthase; Provisional; Region: PRK11784
298386007865	Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520
298386007866	active site residue [active]
298386007867	selenophosphate synthetase; Provisional; Region: PRK00943
298386007868	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
298386007869	dimerization interface [polypeptide binding]; other site
298386007870	putative ATP binding site [chemical binding]; other site
298386007871	Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135
298386007872	putative FMN binding site [chemical binding]; other site
298386007873	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
298386007874	2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli  is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930
298386007875	active site
298386007876	FMN binding site [chemical binding]; other site
298386007877	2,4-decadienoyl-CoA binding site; other site
298386007878	catalytic residue [active]
298386007879	4Fe-4S cluster binding site [ion binding]; other site
298386007880	protease 4; Provisional; Region: PRK10949
298386007881	Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018
298386007882	tandem repeat interface [polypeptide binding]; other site
298386007883	oligomer interface [polypeptide binding]; other site
298386007884	active site residues [active]
298386007885	Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023
298386007886	tandem repeat interface [polypeptide binding]; other site
298386007887	oligomer interface [polypeptide binding]; other site
298386007888	active site residues [active]
298386007889	Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963
298386007890	homodimer interface [polypeptide binding]; other site
298386007891	active site
298386007892	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
298386007893	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
298386007894	C-terminal domain interface [polypeptide binding]; other site
298386007895	GSH binding site (G-site) [chemical binding]; other site
298386007896	dimer interface [polypeptide binding]; other site
298386007897	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
298386007898	N-terminal domain interface [polypeptide binding]; other site
298386007899	dimer interface [polypeptide binding]; other site
298386007900	substrate binding pocket (H-site) [chemical binding]; other site
298386007901	Protein of unknown function (DUF1315); Region: DUF1315; pfam07023
298386007902	Protein of unknown function (DUF2989); Region: DUF2989; pfam11207
298386007903	methionine sulfoxide reductase B; Provisional; Region: PRK00222
298386007904	SelR domain; Region: SelR; pfam01641
298386007905	glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425
298386007906	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
298386007907	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
298386007908	D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020
298386007909	active site
298386007910	phosphate binding residues; other site
298386007911	catalytic residues [active]
298386007912	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298386007913	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_16; cd07263
298386007914	PrkA family serine protein kinase; Provisional; Region: PRK15455
298386007915	AAA ATPase domain; Region: AAA_16; pfam13191
298386007916	PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798
298386007917	hypothetical protein; Provisional; Region: PRK05325
298386007918	SpoVR family protein; Provisional; Region: PRK11767
298386007919	Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719
298386007920	fatty acid metabolism transcriptional regulator FadR; Region: fadR_gamma; TIGR02812
298386007921	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298386007922	DNA-binding site [nucleotide binding]; DNA binding site
298386007923	FadR C-terminal domain; Region: FadR_C; pfam07840
298386007924	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
298386007925	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625
298386007926	transmembrane helices; other site
298386007927	disulfide bond formation protein B; Provisional; Region: PRK01749
298386007928	Uncharacterized protein family (UPF0149); Region: UPF0149; pfam03695
298386007929	Predicted metal-binding protein related to the C-terminal domain of SecA [General function prediction only]; Region: COG3318
298386007930	SEC-C motif; Region: SEC-C; pfam02810
298386007931	CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250
298386007932	NADH(P)-binding; Region: NAD_binding_10; pfam13460
298386007933	NAD binding site [chemical binding]; other site
298386007934	active site
298386007935	tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550
298386007936	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
298386007937	FMN binding site [chemical binding]; other site
298386007938	active site
298386007939	catalytic residues [active]
298386007940	substrate binding site [chemical binding]; other site
298386007941	hypothetical protein; Provisional; Region: PRK05170
298386007942	TIGR02647 family protein; Region: DNA
298386007943	Tim44-like domain; Region: Tim44; pfam04280
298386007944	Predicted membrane protein [Function unknown]; Region: XynA; COG2314
298386007945	TM2 domain; Region: TM2; cl00984
298386007946	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298386007947	WHG domain; Region: WHG; pfam13305
298386007948	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298386007949	putative substrate translocation pore; other site
298386007950	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
298386007951	putative acyl-acceptor binding pocket; other site
298386007952	O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029
298386007953	O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912
298386007954	acyl-activating enzyme (AAE) consensus motif; other site
298386007955	putative AMP binding site [chemical binding]; other site
298386007956	putative active site [active]
298386007957	putative CoA binding site [chemical binding]; other site
298386007958	O-succinylbenzoate synthase; Provisional; Region: PRK05105
298386007959	o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320
298386007960	active site
298386007961	Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303
298386007962	2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126
298386007963	2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449
298386007964	Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037
298386007965	dimer interface [polypeptide binding]; other site
298386007966	tetramer interface [polypeptide binding]; other site
298386007967	PYR/PP interface [polypeptide binding]; other site
298386007968	TPP binding site [chemical binding]; other site
298386007969	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
298386007970	Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009
298386007971	TPP-binding site; other site
298386007972	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
298386007973	chorismate binding enzyme; Region: Chorismate_bind; cl10555
298386007974	aminotransferase AlaT; Validated; Region: PRK09265
298386007975	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
298386007976	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298386007977	homodimer interface [polypeptide binding]; other site
298386007978	catalytic residue [active]
298386007979	5'-nucleotidase; Provisional; Region: PRK03826
298386007980	deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK05318
298386007981	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
298386007982	Zn2+ binding site [ion binding]; other site
298386007983	Mg2+ binding site [ion binding]; other site
298386007984	Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286
298386007985	DTW domain; Region: DTW; cl01221
298386007986	rhomboid family GlyGly-CTERM serine protease; Region: rhom_GG_sort; TIGR03902
298386007987	Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615
298386007988	competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426
298386007989	periplasmic folding chaperone; Provisional; Region: PRK10788
298386007990	SurA N-terminal domain; Region: SurA_N_3; cl07813
298386007991	PPIC-type PPIASE domain; Region: Rotamase; pfam00639
298386007992	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
298386007993	IHF dimer interface [polypeptide binding]; other site
298386007994	IHF - DNA interface [nucleotide binding]; other site
298386007995	DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787
298386007996	Found in ATP-dependent protease La (LON); Region: LON; smart00464
298386007997	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298386007998	Walker A motif; other site
298386007999	ATP binding site [chemical binding]; other site
298386008000	Walker B motif; other site
298386008001	arginine finger; other site
298386008002	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
298386008003	ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342
298386008004	ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689
298386008005	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298386008006	Walker A motif; other site
298386008007	ATP binding site [chemical binding]; other site
298386008008	Walker B motif; other site
298386008009	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086
298386008010	Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740
298386008011	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017
298386008012	oligomer interface [polypeptide binding]; other site
298386008013	active site residues [active]
298386008014	trigger factor; Provisional; Region: tig; PRK01490
298386008015	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
298386008016	Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698
298386008017	bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792
298386008018	Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763
298386008019	NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080
298386008020	homodimer interface [polypeptide binding]; other site
298386008021	NADP binding site [chemical binding]; other site
298386008022	substrate binding site [chemical binding]; other site
298386008023	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
298386008024	active site
298386008025	tetramer interface; other site
298386008026	transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014
298386008027	N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892
298386008028	amino acid/peptide transporter (Peptide:H+ symporter), bacterial; Region: yjdL_sub1_fam; TIGR00924
298386008029	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298386008030	putative substrate translocation pore; other site
298386008031	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
298386008032	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386008033	active site
298386008034	phosphorylation site [posttranslational modification]
298386008035	intermolecular recognition site; other site
298386008036	dimerization interface [polypeptide binding]; other site
298386008037	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386008038	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386008039	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
298386008040	putative effector binding pocket; other site
298386008041	dimerization interface [polypeptide binding]; other site
298386008042	Protein of unknown function (DUF1282); Region: DUF1282; pfam06930
298386008043	amidophosphoribosyltransferase; Provisional; Region: PRK09246
298386008044	Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of  glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715
298386008045	active site
298386008046	tetramer interface [polypeptide binding]; other site
298386008047	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
298386008048	active site
298386008049	Colicin V production protein; Region: Colicin_V; cl00567
298386008050	Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286
298386008051	cell division protein DedD; Provisional; Region: PRK11633
298386008052	Sporulation related domain; Region: SPOR; pfam05036
298386008053	bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846
298386008054	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
298386008055	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
298386008056	acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654
298386008057	malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682
298386008058	tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021
298386008059	Eukaryotic and bacterial pseudouridine synthases similar to E.  coli TruA; Region: PseudoU_synth_EcTruA; cd02570
298386008060	dimerization interface 3.5A [polypeptide binding]; other site
298386008061	active site
298386008062	FimV N-terminal domain; Region: FimV_core; TIGR03505
298386008063	FimV C-terminal domain; Region: FimV_Cterm; TIGR03504
298386008064	aspartate-semialdehyde dehydrogenase; Provisional; Region: PRK14874
298386008065	Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859
298386008066	erythronate-4-phosphate dehydrogenase; Validated; Region: PRK00257
298386008067	D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158
298386008068	ligand binding site [chemical binding]; other site
298386008069	NAD binding site [chemical binding]; other site
298386008070	catalytic site [active]
298386008071	homodimer interface [polypeptide binding]; other site
298386008072	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
298386008073	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
298386008074	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
298386008075	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
298386008076	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967
298386008077	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
298386008078	dimer interface [polypeptide binding]; other site
298386008079	active site
298386008080	bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747
298386008081	Uncharacterized conserved protein [Function unknown]; Region: COG4121
298386008082	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
298386008083	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
298386008084	Beta-Casp domain; Region: Beta-Casp; smart01027
298386008085	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
298386008086	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386008087	undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380
298386008088	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
298386008089	Mg++ binding site [ion binding]; other site
298386008090	putative catalytic motif [active]
298386008091	substrate binding site [chemical binding]; other site
298386008092	Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571
298386008093	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
298386008094	Mg++ binding site [ion binding]; other site
298386008095	SNF2 family N-terminal domain; Region: SNF2_N; pfam00176
298386008096	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
298386008097	ATP binding site [chemical binding]; other site
298386008098	putative Mg++ binding site [ion binding]; other site
298386008099	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
298386008100	nucleotide binding region [chemical binding]; other site
298386008101	ATP-binding site [chemical binding]; other site
298386008102	Uncharacterized conserved protein [Function unknown]; Region: COG4715
298386008103	exonuclease subunit SbcC; Provisional; Region: PRK10246
298386008104	Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; pfam08780
298386008105	Antidote-toxin recognition MazE; Region: Antitoxin-MazE; cl00877
298386008106	PemK-like protein; Region: PemK; cl00995
298386008107	undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphatetransferase; Region: ECA_wecA; TIGR02380
298386008108	This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853
298386008109	Mg++ binding site [ion binding]; other site
298386008110	putative catalytic motif [active]
298386008111	substrate binding site [chemical binding]; other site
298386008112	Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541
298386008113	active site
298386008114	tetramer interface; other site
298386008115	UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057
298386008116	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
298386008117	UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984
298386008118	UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984
298386008119	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
298386008120	UDP glucuronic acid epimerase, extended (e) SDRs; Region: UDP_GE_SDE_e; cd05253
298386008121	putative NAD(P) binding site [chemical binding]; other site
298386008122	active site
298386008123	putative substrate binding site [chemical binding]; other site
298386008124	Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922
298386008125	The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533
298386008126	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
298386008127	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
298386008128	putative ADP-binding pocket [chemical binding]; other site
298386008129	O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425
298386008130	This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811
298386008131	Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438
298386008132	putative ADP-binding pocket [chemical binding]; other site
298386008133	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
298386008134	active site
298386008135	catalytic site [active]
298386008136	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
298386008137	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
298386008138	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
298386008139	Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128
298386008140	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
298386008141	active site
298386008142	HIGH motif; other site
298386008143	nucleotide binding site [chemical binding]; other site
298386008144	tyrosine kinase; Provisional; Region: PRK11519
298386008145	Chain length determinant protein; Region: Wzz; pfam02706
298386008146	G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807
298386008147	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
298386008148	Low molecular weight phosphatase family; Region: LMWPc; cd00115
298386008149	Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451
298386008150	active site
298386008151	polysaccharide export protein Wza; Provisional; Region: PRK15078
298386008152	Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563
298386008153	SLBB domain; Region: SLBB; pfam10531
298386008154	SLBB domain; Region: SLBB; pfam10531
298386008155	Protein of unknown function (DUF2886); Region: DUF2886; pfam11102
298386008156	Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251
298386008157	Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082
298386008158	YfcL protein; Region: YfcL; pfam08891
298386008159	Protein of unknown function, DUF462; Region: DUF462; cl01190
298386008160	Protein of unknown function, DUF462; Region: DUF462; cl01190
298386008161	Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148
298386008162	Predicted nucleoside-diphosphate sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG1086
298386008163	Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160
298386008164	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
298386008165	NAD(P) binding site [chemical binding]; other site
298386008166	homodimer interface [polypeptide binding]; other site
298386008167	substrate binding site [chemical binding]; other site
298386008168	active site
298386008169	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
298386008170	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298386008171	NAD(P) binding site [chemical binding]; other site
298386008172	active site
298386008173	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
298386008174	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
298386008175	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
298386008176	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
298386008177	active site
298386008178	HIGH motif; other site
298386008179	nucleotide binding site [chemical binding]; other site
298386008180	Transposase IS200 like; Region: Y1_Tnp; pfam01797
298386008181	The PB1 domain is a modular domain mediating specific protein-protein interactions which play a role in many critical cell processes, such as osteoclastogenesis, angiogenesis, early cardiovascular development, and cell polarity. A canonical PB1-PB1...; Region: PB1; cl02720
298386008182	PB1 interaction surface [polypeptide binding]; other site
298386008183	PB1 interaction site [polypeptide binding]; other site
298386008184	PB1 interaction site [polypeptide binding]; other site
298386008185	PB1 interaction surface [polypeptide binding]; other site
298386008186	PB1 interaction surface [polypeptide binding]; other site
298386008187	pseudaminic acid synthase; Region: PseI; TIGR03586
298386008188	NeuB family; Region: NeuB; pfam03102
298386008189	C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615
298386008190	NeuB binding interface [polypeptide binding]; other site
298386008191	putative substrate binding site [chemical binding]; other site
298386008192	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
298386008193	pseudaminic acid biosynthesis-associated protein PseG; Region: PseG; TIGR03590
298386008194	Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013
298386008195	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
298386008196	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
298386008197	CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513
298386008198	ligand binding site; other site
298386008199	tetramer interface; other site
298386008200	Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399
298386008201	3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616
298386008202	inhibitor-cofactor binding pocket; inhibition site
298386008203	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298386008204	catalytic residue [active]
298386008205	UDP-N-acetylglucosamine 4,6-dehydratase; Region: PseB; TIGR03589
298386008206	UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237
298386008207	NAD(P) binding site [chemical binding]; other site
298386008208	homodimer interface [polypeptide binding]; other site
298386008209	substrate binding site [chemical binding]; other site
298386008210	active site
298386008211	Putative glycosyl/glycerophosphate transferases involved in teichoic acid biosynthesis TagF/TagB/EpsJ/RodC [Cell envelope biogenesis, outer membrane]; Region: TagB; COG1887
298386008212	CDP-Glycerol:Poly(glycerophosphate) glycerophosphotransferase; Region: Glyphos_transf; pfam04464
298386008213	UPF0126 domain; Region: UPF0126; pfam03458
298386008214	Predicted membrane protein [Function unknown]; Region: COG2860
298386008215	UPF0126 domain; Region: UPF0126; pfam03458
298386008216	Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082
298386008217	Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304
298386008218	Tetramer interface [polypeptide binding]; other site
298386008219	active site
298386008220	FMN-binding site [chemical binding]; other site
298386008221	PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765
298386008222	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
298386008223	active site
298386008224	phosphorylation site [posttranslational modification]
298386008225	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
298386008226	active site
298386008227	P-loop; other site
298386008228	phosphorylation site [posttranslational modification]
298386008229	Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299
298386008230	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
298386008231	mannose-6-phosphate isomerase; Provisional; Region: PRK15131
298386008232	Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429
298386008233	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
298386008234	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298386008235	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
298386008236	dimerization domain swap beta strand [polypeptide binding]; other site
298386008237	regulatory protein interface [polypeptide binding]; other site
298386008238	active site
298386008239	regulatory phosphorylation site [posttranslational modification]; other site
298386008240	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
298386008241	active site
298386008242	phosphorylation site [posttranslational modification]
298386008243	PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569
298386008244	active site
298386008245	P-loop; other site
298386008246	phosphorylation site [posttranslational modification]
298386008247	16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187
298386008248	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
298386008249	RNA binding surface [nucleotide binding]; other site
298386008250	Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554
298386008251	probable active site [active]
298386008252	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
298386008253	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
298386008254	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
298386008255	HlyD family secretion protein; Region: HlyD_3; pfam13437
298386008256	Response regulator receiver domain; Region: Response_reg; pfam00072
298386008257	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386008258	active site
298386008259	phosphorylation site [posttranslational modification]
298386008260	intermolecular recognition site; other site
298386008261	dimerization interface [polypeptide binding]; other site
298386008262	Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435
298386008263	Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409
298386008264	C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190
298386008265	putative dimer interface [polypeptide binding]; other site
298386008266	N-terminal domain interface [polypeptide binding]; other site
298386008267	putative substrate binding pocket (H-site) [chemical binding]; other site
298386008268	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
298386008269	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815
298386008270	dimer interface [polypeptide binding]; other site
298386008271	active site
298386008272	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
298386008273	substrate binding site [chemical binding]; other site
298386008274	catalytic residue [active]
298386008275	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386008276	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386008277	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
298386008278	dimerization interface [polypeptide binding]; other site
298386008279	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
298386008280	putative catalytic site [active]
298386008281	putative metal binding site [ion binding]; other site
298386008282	putative phosphate binding site [ion binding]; other site
298386008283	BCCT family transporter; Region: BCCT; pfam02028
298386008284	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
298386008285	Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086
298386008286	putative catalytic site [active]
298386008287	putative phosphate binding site [ion binding]; other site
298386008288	active site
298386008289	metal binding site A [ion binding]; metal-binding site
298386008290	DNA binding site [nucleotide binding]
298386008291	putative AP binding site [nucleotide binding]; other site
298386008292	putative metal binding site B [ion binding]; other site
298386008293	glutaredoxin 2; Provisional; Region: PRK10387
298386008294	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
298386008295	C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199
298386008296	N-terminal domain interface [polypeptide binding]; other site
298386008297	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
298386008298	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386008299	dimer interface [polypeptide binding]; other site
298386008300	conserved gate region; other site
298386008301	putative PBP binding loops; other site
298386008302	ABC-ATPase subunit interface; other site
298386008303	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
298386008304	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386008305	dimer interface [polypeptide binding]; other site
298386008306	conserved gate region; other site
298386008307	putative PBP binding loops; other site
298386008308	ABC-ATPase subunit interface; other site
298386008309	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
298386008310	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
298386008311	substrate binding pocket [chemical binding]; other site
298386008312	membrane-bound complex binding site; other site
298386008313	hinge residues; other site
298386008314	ABC-type histidine transport system, ATPase component [Amino acid transport and metabolism]; Region: HisP; COG4598
298386008315	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298386008316	Walker A/P-loop; other site
298386008317	ATP binding site [chemical binding]; other site
298386008318	Q-loop/lid; other site
298386008319	ABC transporter signature motif; other site
298386008320	Walker B; other site
298386008321	D-loop; other site
298386008322	H-loop/switch region; other site
298386008323	The substrate binding domain of a cellulose-binding protein from Thermotoga maritima contains the type 2 periplasmic binding fold; Region: PBP2_TmCBP_oligosaccharides_like; cd08509
298386008324	substrate binding site [chemical binding]; other site
298386008325	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
298386008326	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
298386008327	dimerization interface [polypeptide binding]; other site
298386008328	putative DNA binding site [nucleotide binding]; other site
298386008329	putative Zn2+ binding site [ion binding]; other site
298386008330	Predicted membrane protein [Function unknown]; Region: COG1288
298386008331	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
298386008332	hypothetical protein; Provisional; Region: PRK07205
298386008333	M20 Peptidase Xaa-His dipeptidase (PepV) degrades hydrophobic dipeptides; Region: M20_PepV; cd03888
298386008334	active site
298386008335	metal binding site [ion binding]; metal-binding site
298386008336	uncharacterized domain; Region: TIGR00702
298386008337	YcaO-like family; Region: YcaO; pfam02624
298386008338	Protein of unknown function (DUF3360); Region: DUF3360; pfam11840
298386008339	formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255
298386008340	Pyruvate formate lyase 1; Region: PFL1; cd01678
298386008341	coenzyme A binding site [chemical binding]; other site
298386008342	active site
298386008343	catalytic residues [active]
298386008344	glycine loop; other site
298386008345	pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145
298386008346	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
298386008347	FeS/SAM binding site; other site
298386008348	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
298386008349	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181
298386008350	Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331
298386008351	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
298386008352	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386008353	Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772
298386008354	Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979
298386008355	Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187
298386008356	dimer interface [polypeptide binding]; other site
298386008357	active site
298386008358	metal binding site [ion binding]; metal-binding site
298386008359	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
298386008360	Type 1 glutamine amidotransferase (GATase1)-like domain found in proteins similar to Escherichia coli Hsp31 protein; Region: GATase1_Hsp31_like; cd03141
298386008361	potential catalytic triad [active]
298386008362	conserved cys residue [active]
298386008363	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386008364	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386008365	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
298386008366	putative effector binding pocket; other site
298386008367	dimerization interface [polypeptide binding]; other site
298386008368	Response regulator of citrate/malate metabolism [Transcription / Signal transduction mechanisms]; Region: CitB; COG4565
298386008369	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386008370	active site
298386008371	phosphorylation site [posttranslational modification]
298386008372	intermolecular recognition site; other site
298386008373	dimerization interface [polypeptide binding]; other site
298386008374	Transcriptional regulator; Region: CitT; pfam12431
298386008375	Signal transduction histidine kinase regulating citrate/malate metabolism [Signal transduction mechanisms]; Region: CitA; COG3290
298386008376	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386008377	ATP binding site [chemical binding]; other site
298386008378	Mg2+ binding site [ion binding]; other site
298386008379	G-X-G motif; other site
298386008380	formate--tetrahydrofolate ligase; Provisional; Region: PRK13506
298386008381	Formyltetrahydrofolate synthetase (FTHFS) catalyzes the ATP-dependent activation of formate ion via its addition to the N10 position of tetrahydrofolate. FTHFS is a highly expressed key enzyme in both the Wood-Ljungdahl pathway of autotrophic CO2...; Region: FTHFS; cd00477
298386008382	Potassium binding sites [ion binding]; other site
298386008383	Cesium cation binding sites [ion binding]; other site
298386008384	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
298386008385	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386008386	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
298386008387	putative dimerization interface [polypeptide binding]; other site
298386008388	formate transporter FocA; Region: formate_focA; TIGR04060
298386008389	FOG: CBS domain [General function prediction only]; Region: COG0517
298386008390	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354
298386008391	Predicted membrane protein [Function unknown]; Region: COG3235
298386008392	Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891
298386008393	hypothetical protein; Validated; Region: PRK05445
298386008394	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
298386008395	Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192
298386008396	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298386008397	dimerization interface [polypeptide binding]; other site
298386008398	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298386008399	dimer interface [polypeptide binding]; other site
298386008400	phosphorylation site [posttranslational modification]
298386008401	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386008402	ATP binding site [chemical binding]; other site
298386008403	Mg2+ binding site [ion binding]; other site
298386008404	G-X-G motif; other site
298386008405	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
298386008406	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386008407	active site
298386008408	phosphorylation site [posttranslational modification]
298386008409	intermolecular recognition site; other site
298386008410	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
298386008411	Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420
298386008412	Protein of unknown function; Region: YhfT; pfam10797
298386008413	Protein of unknown function DUF2620; Region: DUF2620; pfam10941
298386008414	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
298386008415	active site
298386008416	substrate binding pocket [chemical binding]; other site
298386008417	homodimer interaction site [polypeptide binding]; other site
298386008418	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298386008419	DNA-binding site [nucleotide binding]; DNA binding site
298386008420	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
298386008421	active site
298386008422	P-loop; other site
298386008423	phosphorylation site [posttranslational modification]
298386008424	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
298386008425	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
298386008426	methionine cluster; other site
298386008427	PTS system, Lactose/Cellobiose specific IIA subunit; Region: PTS_IIA; pfam02255
298386008428	active site
298386008429	phosphorylation site [posttranslational modification]
298386008430	metal binding site [ion binding]; metal-binding site
298386008431	Chloramphenicol phosphotransferase-like protein; Region: CPT; pfam07931
298386008432	AAA domain; Region: AAA_18; pfam13238
298386008433	P-loop motif; other site
298386008434	ATP binding site [chemical binding]; other site
298386008435	Chloramphenicol (Cm) binding site [chemical binding]; other site
298386008436	catalytic residue [active]
298386008437	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
298386008438	aromatic chitin/cellulose binding site residues [chemical binding]; other site
298386008439	Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415
298386008440	putative mutase; Provisional; Region: PRK12383
298386008441	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811
298386008442	dimer interface [polypeptide binding]; other site
298386008443	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
298386008444	active site
298386008445	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
298386008446	substrate binding site [chemical binding]; other site
298386008447	catalytic residue [active]
298386008448	Protein of unknown function; Region: YhfT; pfam10797
298386008449	Protein of unknown function DUF2620; Region: DUF2620; pfam10941
298386008450	Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530
298386008451	active site
298386008452	substrate binding pocket [chemical binding]; other site
298386008453	homodimer interaction site [polypeptide binding]; other site
298386008454	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298386008455	DNA-binding site [nucleotide binding]; DNA binding site
298386008456	Uncharacterized protein conserved in bacteria (DUF2057); Region: DUF2057; pfam09829
298386008457	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
298386008458	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
298386008459	trimer interface [polypeptide binding]; other site
298386008460	eyelet of channel; other site
298386008461	23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088
298386008462	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298386008463	S-adenosylmethionine binding site [chemical binding]; other site
298386008464	Protein of unknown function, DUF399; Region: DUF399; pfam04187
298386008465	Type I periplasmic ligand-binding domain of uncharacterized ABC-type transport systems that are predicted to be involved in the uptake of amino acids, peptides, or inorganic ions; Region: PBP1_ABC_uncharacterized_transporter; cd06325
298386008466	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
298386008467	zinc binding site [ion binding]; other site
298386008468	putative ligand binding site [chemical binding]; other site
298386008469	Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cd06574
298386008470	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
298386008471	TM-ABC transporter signature motif; other site
298386008472	ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: PhnK; COG1101
298386008473	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298386008474	Walker A/P-loop; other site
298386008475	ATP binding site [chemical binding]; other site
298386008476	Q-loop/lid; other site
298386008477	ABC transporter signature motif; other site
298386008478	Walker B; other site
298386008479	D-loop; other site
298386008480	H-loop/switch region; other site
298386008481	hypothetical protein; Provisional; Region: PRK01816
298386008482	acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180
298386008483	propionate/acetate kinase; Provisional; Region: PRK12379
298386008484	phosphate acetyltransferase; Reviewed; Region: PRK05632
298386008485	DRTGG domain; Region: DRTGG; pfam07085
298386008486	phosphate acetyltransferase; Region: pta; TIGR00651
298386008487	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386008488	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386008489	formate transporter FocA; Region: formate_focA; TIGR04060
298386008490	Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841
298386008491	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
298386008492	active site
298386008493	metal binding site [ion binding]; metal-binding site
298386008494	homotetramer interface [polypeptide binding]; other site
298386008495	FOG: CBS domain [General function prediction only]; Region: COG0517
298386008496	The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_17; cd04630
298386008497	Nitrogen regulatory protein P-II; Region: P-II; smart00938
298386008498	Protein of unknown function (DUF1538); Region: DUF1538; pfam07556
298386008499	Protein of unknown function (DUF1538); Region: DUF1538; pfam07556
298386008500	atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242
298386008501	Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090
298386008502	putative NAD(P) binding site [chemical binding]; other site
298386008503	putative active site [active]
298386008504	Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127
298386008505	FtsX-like permease family; Region: FtsX; pfam02687
298386008506	FtsX-like permease family; Region: FtsX; pfam02687
298386008507	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
298386008508	lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211
298386008509	Walker A/P-loop; other site
298386008510	ATP binding site [chemical binding]; other site
298386008511	Q-loop/lid; other site
298386008512	ABC transporter signature motif; other site
298386008513	Walker B; other site
298386008514	D-loop; other site
298386008515	H-loop/switch region; other site
298386008516	Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822
298386008517	active site
298386008518	catalytic triad [active]
298386008519	oxyanion hole [active]
298386008520	switch loop; other site
298386008521	short chain dehydrogenase; Provisional; Region: PRK05993
298386008522	17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374
298386008523	NADP binding site [chemical binding]; other site
298386008524	active site
298386008525	steroid binding site; other site
298386008526	Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118
298386008527	ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956
298386008528	META domain; Region: META; pfam03724
298386008529	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
298386008530	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
298386008531	ligand binding site [chemical binding]; other site
298386008532	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
298386008533	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
298386008534	DNA binding site [nucleotide binding]
298386008535	Cu(I)-responsive transcriptional regulator; Region: CueR; TIGR02044
298386008536	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
298386008537	DNA binding residues [nucleotide binding]
298386008538	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
298386008539	metal-binding site [ion binding]
298386008540	Heavy-metal-associated domain; Region: HMA; pfam00403
298386008541	copper exporting ATPase; Provisional; Region: copA; PRK10671
298386008542	Heavy-metal-associated domain; Region: HMA; pfam00403
298386008543	Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371
298386008544	metal-binding site [ion binding]
298386008545	E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122
298386008546	Soluble P-type ATPase [General function prediction only]; Region: COG4087
298386008547	TraB family; Region: TraB; pfam01963
298386008548	Protein of unknown function (DUF3149); Region: DUF3149; pfam11346
298386008549	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840
298386008550	Smr domain; Region: Smr; pfam01713
298386008551	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
298386008552	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386008553	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386008554	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
298386008555	substrate binding pocket [chemical binding]; other site
298386008556	dimerization interface [polypeptide binding]; other site
298386008557	This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002
298386008558	putative deacylase active site [active]
298386008559	bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558
298386008560	Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405
298386008561	active site
298386008562	metal binding site [ion binding]; metal-binding site
298386008563	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
298386008564	Na+/H+ antiporter [Energy production and conversion]; Region: NhaC; COG1757
298386008565	Cache domain; Region: Cache_1; pfam02743
298386008566	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
298386008567	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298386008568	dimerization interface [polypeptide binding]; other site
298386008569	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
298386008570	dimer interface [polypeptide binding]; other site
298386008571	putative CheW interface [polypeptide binding]; other site
298386008572	Cache domain; Region: Cache_1; pfam02743
298386008573	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298386008574	dimerization interface [polypeptide binding]; other site
298386008575	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
298386008576	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
298386008577	dimer interface [polypeptide binding]; other site
298386008578	putative CheW interface [polypeptide binding]; other site
298386008579	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
298386008580	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
298386008581	2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198
298386008582	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
298386008583	hypothetical protein; Provisional; Region: PRK10941
298386008584	Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369
298386008585	Invasion gene expression up-regulator, SirB; Region: SirB; pfam04247
298386008586	N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328
298386008587	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298386008588	peptide chain release factor 1; Validated; Region: prfA; PRK00591
298386008589	This domain is found in peptide chain release factors; Region: PCRF; smart00937
298386008590	RF-1 domain; Region: RF-1; pfam00472
298386008591	glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045
298386008592	NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213
298386008593	tRNA; other site
298386008594	putative tRNA binding site [nucleotide binding]; other site
298386008595	putative NADP binding site [chemical binding]; other site
298386008596	Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745
298386008597	outer membrane lipoprotein LolB; Provisional; Region: lolB; PRK00022
298386008598	Outer membrane lipoprotein LolB; Region: LolB; pfam03550
298386008599	4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343
298386008600	GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288
298386008601	GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544
298386008602	ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259
298386008603	N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793
298386008604	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
298386008605	active site
298386008606	Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462
298386008607	putative active site [active]
298386008608	catalytic residue [active]
298386008609	GTP-binding protein YchF; Reviewed; Region: PRK09601
298386008610	YchF GTPase; Region: YchF; cd01900
298386008611	G1 box; other site
298386008612	GTP/Mg2+ binding site [chemical binding]; other site
298386008613	Switch I region; other site
298386008614	G2 box; other site
298386008615	Switch II region; other site
298386008616	G3 box; other site
298386008617	G4 box; other site
298386008618	G5 box; other site
298386008619	TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867
298386008620	2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Provisional; Region: PRK08849
298386008621	ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314
298386008622	monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056
298386008623	Transglycosylase; Region: Transgly; cl17702
298386008624	(dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325
298386008625	Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919
298386008626	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
298386008627	FeS/SAM binding site; other site
298386008628	TRAM domain; Region: TRAM; pfam01938
298386008629	Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702
298386008630	PhoH-like protein; Region: PhoH; pfam02562
298386008631	metal-binding heat shock protein; Provisional; Region: PRK00016
298386008632	Putative Mg2+ and Co2+ transporter CorC [Inorganic ion transport and metabolism]; Region: CorC; COG4535
298386008633	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
298386008634	Transporter associated domain; Region: CorC_HlyC; smart01091
298386008635	apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302
298386008636	Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571
298386008637	putative active site [active]
298386008638	catalytic triad [active]
298386008639	putative dimer interface [polypeptide binding]; other site
298386008640	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524
298386008641	putative amphipathic alpha helix; other site
298386008642	hypothetical protein; Provisional; Region: PRK11032
298386008643	leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390
298386008644	catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812
298386008645	HIGH motif; other site
298386008646	Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603
298386008647	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
298386008648	active site
298386008649	KMSKS motif; other site
298386008650	Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958
298386008651	tRNA binding surface [nucleotide binding]; other site
298386008652	Lipopolysaccharide-assembly; Region: LptE; cl01125
298386008653	DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574
298386008654	DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144
298386008655	iojap-like ribosome-associated protein; Region: iojap_ybeB; TIGR00090
298386008656	rRNA large subunit methyltransferase; Provisional; Region: PRK00103
298386008657	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
298386008658	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
298386008659	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
298386008660	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
298386008661	Lipoproteins [Cell envelope biogenesis, outer membrane]; Region: RlpA; COG0797
298386008662	Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330
298386008663	Sporulation related domain; Region: SPOR; pfam05036
298386008664	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
298386008665	D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793
298386008666	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
298386008667	hypothetical protein; Provisional; Region: PRK04998
298386008668	lipoate-protein ligase B; Provisional; Region: PRK14342
298386008669	lipoyl synthase; Provisional; Region: PRK05481
298386008670	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
298386008671	FeS/SAM binding site; other site
298386008672	lipoprotein; Provisional; Region: PRK11679
298386008673	NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804
298386008674	Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950
298386008675	dihydrodipicolinate synthase; Region: dapA; TIGR00674
298386008676	dimer interface [polypeptide binding]; other site
298386008677	active site
298386008678	catalytic residue [active]
298386008679	glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589
298386008680	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893
298386008681	ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_2; cd04869
298386008682	Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450
298386008683	Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017
298386008684	catalytic triad [active]
298386008685	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628
298386008686	Domain of unknown function DUF20; Region: UPF0118; pfam01594
298386008687	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
298386008688	Peptidase family M48; Region: Peptidase_M48; cl12018
298386008689	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298386008690	TPR motif; other site
298386008691	binding surface
298386008692	Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034
298386008693	ArsC family; Region: ArsC; pfam03960
298386008694	catalytic residues [active]
298386008695	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
298386008696	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
298386008697	Predicted membrane protein (DUF2069); Region: DUF2069; pfam09842
298386008698	Uncharacterized protein conserved in bacteria (DUF2066); Region: DUF2066; pfam09839
298386008699	Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233
298386008700	Transposase IS200 like; Region: Y1_Tnp; pfam01797
298386008701	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
298386008702	active site
298386008703	phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385
298386008704	PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196
298386008705	dimerization interface [polypeptide binding]; other site
298386008706	putative ATP binding site [chemical binding]; other site
298386008707	phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647
298386008708	Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645
298386008709	active site
298386008710	substrate binding site [chemical binding]; other site
298386008711	cosubstrate binding site; other site
298386008712	catalytic site [active]
298386008713	Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121
298386008714	Glutamine amidotransferases class-II (Gn-AT)_YafJ-type.  YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea.  YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908
298386008715	putative active site [active]
298386008716	putative dimer interface [polypeptide binding]; other site
298386008717	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
298386008718	dimer interface [polypeptide binding]; other site
298386008719	active site
298386008720	putative transporter; Provisional; Region: PRK11660
298386008721	Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792
298386008722	Sulfate transporter family; Region: Sulfate_transp; pfam00916
298386008723	Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042
298386008724	acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463
298386008725	Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771
298386008726	Acyl-CoA dehydrogenase; Region: ACAD; cd00567
298386008727	active site
298386008728	Domain of unknown function (DUF1974); Region: DUF1974; pfam09317
298386008729	TIGR03503 family protein; Region: TIGR03503
298386008730	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
298386008731	DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131
298386008732	active site
298386008733	catalytic site [active]
298386008734	substrate binding site [chemical binding]; other site
298386008735	RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278
298386008736	RNA/DNA hybrid binding site [nucleotide binding]; other site
298386008737	active site
298386008738	Methyltransferase domain; Region: Methyltransf_11; pfam08241
298386008739	hydroxyacylglutathione hydrolase; Region: GSH_gloB; TIGR03413
298386008740	membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783
298386008741	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
298386008742	N-acetyl-D-glucosamine binding site [chemical binding]; other site
298386008743	catalytic residue [active]
298386008744	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
298386008745	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
298386008746	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
298386008747	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
298386008748	Protein of unknown function (DUF1282); Region: DUF1282; pfam06930
298386008749	hypothetical protein; Provisional; Region: PRK05421
298386008750	putative catalytic site [active]
298386008751	putative metal binding site [ion binding]; other site
298386008752	putative phosphate binding site [ion binding]; other site
298386008753	Domain of unknown function (DUF1904); Region: DUF1904; pfam08921
298386008754	ABC-type oligopeptide transport system, ATPase component [Amino acid transport and metabolism]; Region: AppF; COG4608
298386008755	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
298386008756	Walker A/P-loop; other site
298386008757	ATP binding site [chemical binding]; other site
298386008758	Q-loop/lid; other site
298386008759	ABC transporter signature motif; other site
298386008760	Walker B; other site
298386008761	D-loop; other site
298386008762	H-loop/switch region; other site
298386008763	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
298386008764	ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444
298386008765	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
298386008766	Walker A/P-loop; other site
298386008767	ATP binding site [chemical binding]; other site
298386008768	Q-loop/lid; other site
298386008769	ABC transporter signature motif; other site
298386008770	Walker B; other site
298386008771	D-loop; other site
298386008772	H-loop/switch region; other site
298386008773	oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727
298386008774	The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497
298386008775	Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496
298386008776	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239
298386008777	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386008778	dimer interface [polypeptide binding]; other site
298386008779	conserved gate region; other site
298386008780	putative PBP binding loops; other site
298386008781	ABC-ATPase subunit interface; other site
298386008782	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174
298386008783	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386008784	dimer interface [polypeptide binding]; other site
298386008785	conserved gate region; other site
298386008786	putative PBP binding loops; other site
298386008787	ABC-ATPase subunit interface; other site
298386008788	D,D-heptose 1,7-bisphosphate phosphatase; Validated; Region: PRK08942
298386008789	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
298386008790	active site
298386008791	motif I; other site
298386008792	motif II; other site
298386008793	HAD-hyrolase-like; Region: Hydrolase_like; pfam13242
298386008794	DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153
298386008795	ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258
298386008796	Walker A/P-loop; other site
298386008797	ATP binding site [chemical binding]; other site
298386008798	Q-loop/lid; other site
298386008799	ABC transporter signature motif; other site
298386008800	Walker B; other site
298386008801	D-loop; other site
298386008802	H-loop/switch region; other site
298386008803	This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930
298386008804	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386008805	dimer interface [polypeptide binding]; other site
298386008806	conserved gate region; other site
298386008807	ABC-ATPase subunit interface; other site
298386008808	DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063
298386008809	NLPA lipoprotein; Region: Lipoprotein_9; cl17547
298386008810	Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281
298386008811	homodimer interaction site [polypeptide binding]; other site
298386008812	cofactor binding site; other site
298386008813	prolyl-tRNA synthetase; Provisional; Region: PRK09194
298386008814	Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779
298386008815	dimer interface [polypeptide binding]; other site
298386008816	motif 1; other site
298386008817	active site
298386008818	motif 2; other site
298386008819	INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334
298386008820	putative deacylase active site [active]
298386008821	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
298386008822	active site
298386008823	motif 3; other site
298386008824	ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861
298386008825	anticodon binding site; other site
298386008826	Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209
298386008827	active site
298386008828	nucleophile elbow; other site
298386008829	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298386008830	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298386008831	metal binding site [ion binding]; metal-binding site
298386008832	active site
298386008833	I-site; other site
298386008834	hypothetical protein; Provisional; Region: PRK04964
298386008835	Domain of unknown function (DUF4250); Region: DUF4250; pfam14056
298386008836	solute carrier 6 subfamily, Fusobacterium nucleatum Tyt1-like; solute-binding domain; Region: SLC6sbd_Tyt1-Like; cd10336
298386008837	Na2 binding site [ion binding]; other site
298386008838	putative substrate binding site 1 [chemical binding]; other site
298386008839	Na binding site 1 [ion binding]; other site
298386008840	putative substrate binding site 2 [chemical binding]; other site
298386008841	Cytochrome c; Region: Cytochrom_C; cl11414
298386008842	tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660
298386008843	N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992
298386008844	Ligand Binding Site [chemical binding]; other site
298386008845	TilS substrate binding domain; Region: TilS; pfam09179
298386008846	TilS substrate C-terminal domain; Region: TilS_C; pfam11734
298386008847	acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724
298386008848	acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198
298386008849	DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673
298386008850	Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433
298386008851	putative active site [active]
298386008852	putative PHP Thumb interface [polypeptide binding]; other site
298386008853	DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485
298386008854	generic binding surface I; other site
298386008855	generic binding surface II; other site
298386008856	bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182
298386008857	RNA/DNA hybrid binding site [nucleotide binding]; other site
298386008858	active site
298386008859	lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025
298386008860	ipid-A-disaccharide synthase; Provisional; Region: PRK14089
298386008861	UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289
298386008862	UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351
298386008863	active site
298386008864	FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288
298386008865	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892
298386008866	UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613
298386008867	UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352
298386008868	trimer interface [polypeptide binding]; other site
298386008869	active site
298386008870	UDP-GlcNAc binding site [chemical binding]; other site
298386008871	lipid binding site [chemical binding]; lipid-binding site
298386008872	periplasmic chaperone; Provisional; Region: PRK10780
298386008873	Outer membrane protein (OmpH-like); Region: OmpH; smart00935
298386008874	outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067
298386008875	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
298386008876	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
298386008877	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
298386008878	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
298386008879	Surface antigen; Region: Bac_surface_Ag; pfam01103
298386008880	zinc metallopeptidase RseP; Provisional; Region: PRK10779
298386008881	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
298386008882	active site
298386008883	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
298386008884	protein binding site [polypeptide binding]; other site
298386008885	PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989
298386008886	protein binding site [polypeptide binding]; other site
298386008887	RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163
298386008888	putative substrate binding region [chemical binding]; other site
298386008889	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447
298386008890	1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670
298386008891	1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436
298386008892	DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288
298386008893	CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624
298386008894	CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575
298386008895	Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020
298386008896	Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475
298386008897	catalytic residue [active]
298386008898	putative FPP diphosphate  binding site; other site
298386008899	putative FPP binding hydrophobic cleft; other site
298386008900	dimer interface [polypeptide binding]; other site
298386008901	putative IPP diphosphate binding site; other site
298386008902	ribosome recycling factor; Reviewed; Region: frr; PRK00083
298386008903	Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation.  Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520
298386008904	hinge region; other site
298386008905	UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254
298386008906	putative nucleotide binding site [chemical binding]; other site
298386008907	uridine monophosphate binding site [chemical binding]; other site
298386008908	homohexameric interface [polypeptide binding]; other site
298386008909	elongation factor Ts; Provisional; Region: tsf; PRK09377
298386008910	UBA/TS-N domain; Region: UBA; pfam00627
298386008911	Elongation factor TS; Region: EF_TS; pfam00889
298386008912	Elongation factor TS; Region: EF_TS; pfam00889
298386008913	Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425
298386008914	rRNA interaction site [nucleotide binding]; other site
298386008915	S8 interaction site; other site
298386008916	putative laminin-1 binding site; other site
298386008917	Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086
298386008918	active site
298386008919	PII uridylyl-transferase; Provisional; Region: PRK05007
298386008920	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
298386008921	metal binding triad; other site
298386008922	GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335
298386008923	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
298386008924	Zn2+ binding site [ion binding]; other site
298386008925	Mg2+ binding site [ion binding]; other site
298386008926	ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900
298386008927	C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899
298386008928	hypothetical protein; Provisional; Region: PRK13677
298386008929	flavodoxin; Provisional; Region: PRK08105
298386008930	Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564
298386008931	tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563
298386008932	probable active site [active]
298386008933	tRNA pseudouridine synthase C; Region: DUF446; pfam04287
298386008934	Protein of unknown function (DUF3549); Region: DUF3549; pfam12069
298386008935	Protein of unknown function (DUF3301); Region: DUF3301; pfam11743
298386008936	Protein of unknown function (DUF2789); Region: DUF2789; pfam10982
298386008937	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
298386008938	Zn-ribbon-containing, possibly nucleic-acid-binding protein (DUF2310); Region: DUF2310; pfam10071
298386008939	SecY interacting protein Syd; Provisional; Region: PRK04968
298386008940	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904
298386008941	7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792
298386008942	Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780
298386008943	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298386008944	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298386008945	binding surface
298386008946	TPR motif; other site
298386008947	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298386008948	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298386008949	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298386008950	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298386008951	metal binding site [ion binding]; metal-binding site
298386008952	active site
298386008953	I-site; other site
298386008954	Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611
298386008955	Domain of unknown function (DUF3412); Region: DUF3412; pfam11892
298386008956	flap endonuclease-like protein; Provisional; Region: PRK09482
298386008957	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
298386008958	active site
298386008959	metal binding site 1 [ion binding]; metal-binding site
298386008960	putative 5' ssDNA interaction site; other site
298386008961	metal binding site 3; metal-binding site
298386008962	metal binding site 2 [ion binding]; metal-binding site
298386008963	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
298386008964	putative DNA binding site [nucleotide binding]; other site
298386008965	putative metal binding site [ion binding]; other site
298386008966	putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760
298386008967	FtsJ-like methyltransferase; Region: FtsJ; cl17430
298386008968	Protein of unknown function (DUF423); Region: DUF423; pfam04241
298386008969	Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695
298386008970	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
298386008971	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386008972	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
298386008973	dimerization interface [polypeptide binding]; other site
298386008974	substrate binding pocket [chemical binding]; other site
298386008975	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
298386008976	Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453
298386008977	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
298386008978	catalytic residue [active]
298386008979	Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166
298386008980	sulfur acceptor protein CsdL; Provisional; Region: PRK15116
298386008981	Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755
298386008982	putative ATP binding site [chemical binding]; other site
298386008983	putative substrate interface [chemical binding]; other site
298386008984	murein transglycosylase A; Provisional; Region: mltA; PRK11162
298386008985	MltA specific insert domain; Region: MltA; smart00925
298386008986	3D domain; Region: 3D; pfam06725
298386008987	Protein of unknown function (DUF2850); Region: DUF2850; pfam11012
298386008988	N-acetylglutamate synthase; Validated; Region: PRK05279
298386008989	AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237
298386008990	putative feedback inhibition sensing region; other site
298386008991	putative nucleotide binding site [chemical binding]; other site
298386008992	putative substrate binding site [chemical binding]; other site
298386008993	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298386008994	Coenzyme A binding pocket [chemical binding]; other site
298386008995	exonuclease V subunit alpha; Provisional; Region: recD; PRK10875
298386008996	AAA domain; Region: AAA_30; pfam13604
298386008997	Family description; Region: UvrD_C_2; pfam13538
298386008998	exonuclease V subunit beta; Provisional; Region: recB; PRK10876
298386008999	Part of AAA domain; Region: AAA_19; pfam13245
298386009000	NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226
298386009001	NAD(P) binding pocket [chemical binding]; other site
298386009002	Family description; Region: UvrD_C_2; pfam13538
298386009003	PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705
298386009004	exonuclease V subunit gamma; Provisional; Region: recC; PRK11069
298386009005	exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450
298386009006	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
298386009007	C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325
298386009008	gating phenylalanine in ion channel; other site
298386009009	putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837
298386009010	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386009011	C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420
298386009012	putative dimerization interface [polypeptide binding]; other site
298386009013	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
298386009014	YebG protein; Region: YebG; pfam07130
298386009015	2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase; Region: DapD_gpp; TIGR03536
298386009016	Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal...; Region: LbH_THP_succinylT_putative; cd04649
298386009017	putative trimer interface [polypeptide binding]; other site
298386009018	putative CoA binding site [chemical binding]; other site
298386009019	Protein of unknown function (DUF2799); Region: DUF2799; pfam10973
298386009020	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298386009021	drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710
298386009022	putative substrate translocation pore; other site
298386009023	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
298386009024	Transposase; Region: HTH_Tnp_1; cl17663
298386009025	Transposase; Region: HTH_Tnp_1; cl17663
298386009026	Homeodomain-like domain; Region: HTH_32; pfam13565
298386009027	Integrase core domain; Region: rve; pfam00665
298386009028	Integrase core domain; Region: rve_3; pfam13683
298386009029	Homeodomain-like domain; Region: HTH_23; pfam13384
298386009030	Winged helix-turn helix; Region: HTH_29; pfam13551
298386009031	Winged helix-turn helix; Region: HTH_33; pfam13592
298386009032	DDE superfamily endonuclease; Region: DDE_3; pfam13358
298386009033	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
298386009034	ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346
298386009035	Clp amino terminal domain; Region: Clp_N; pfam02861
298386009036	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298386009037	Walker A motif; other site
298386009038	ATP binding site [chemical binding]; other site
298386009039	Walker B motif; other site
298386009040	arginine finger; other site
298386009041	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298386009042	Walker A motif; other site
298386009043	ATP binding site [chemical binding]; other site
298386009044	Walker B motif; other site
298386009045	C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431
298386009046	Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650
298386009047	Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496
298386009048	23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180
298386009049	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
298386009050	RNA binding surface [nucleotide binding]; other site
298386009051	Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869
298386009052	active site
298386009053	outer membrane biogenesis protein BamD; Provisional; Region: PRK10866
298386009054	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
298386009055	30S subunit binding site; other site
298386009056	bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622
298386009057	chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797
298386009058	Prephenate dehydratase; Region: PDT; pfam00800
298386009059	C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905
298386009060	putative L-Phe binding site [chemical binding]; other site
298386009061	bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199
298386009062	chorismate mutase domain of T-protein; Region: CM_T; TIGR01799
298386009063	prephenate dehydrogenase; Validated; Region: PRK08507
298386009064	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755
298386009065	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
298386009066	Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275
298386009067	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
298386009068	Histidine kinase; Region: His_kinase; pfam06580
298386009069	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386009070	ATP binding site [chemical binding]; other site
298386009071	Mg2+ binding site [ion binding]; other site
298386009072	G-X-G motif; other site
298386009073	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
298386009074	YheO-like PAS domain; Region: PAS_6; pfam08348
298386009075	HTH domain; Region: HTH_22; pfam13309
298386009076	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
298386009077	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
298386009078	homotrimer interaction site [polypeptide binding]; other site
298386009079	putative active site [active]
298386009080	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298386009081	putative substrate translocation pore; other site
298386009082	phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881
298386009083	DDE domain; Region: DDE_Tnp_IS240; pfam13610
298386009084	Alanine dehydrogenase/PNT, N-terminal domain; Region: AlaDh_PNT_N; pfam05222
298386009085	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
298386009086	NAD binding site [chemical binding]; other site
298386009087	putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697
298386009088	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386009089	active site
298386009090	phosphorylation site [posttranslational modification]
298386009091	intermolecular recognition site; other site
298386009092	dimerization interface [polypeptide binding]; other site
298386009093	LytTr DNA-binding domain; Region: LytTR; smart00850
298386009094	Protein of unknown function (DUF2799); Region: DUF2799; pfam10973
298386009095	Carbon starvation protein CstA; Region: CstA; pfam02554
298386009096	Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966
298386009097	C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722
298386009098	50S ribosomal protein L19; Provisional; Region: rplS; PRK05338
298386009099	tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026
298386009100	16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122
298386009101	RimM N-terminal domain; Region: RimM; pfam01782
298386009102	PRC-barrel domain; Region: PRC; pfam05239
298386009103	30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040
298386009104	signal recognition particle protein; Provisional; Region: PRK10867
298386009105	SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963
298386009106	The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115
298386009107	P loop; other site
298386009108	GTP binding site [chemical binding]; other site
298386009109	Signal peptide binding domain; Region: SRP_SPB; pfam02978
298386009110	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137
298386009111	hypothetical protein; Provisional; Region: PRK11573
298386009112	Domain of unknown function DUF21; Region: DUF21; pfam01595
298386009113	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
298386009114	Transporter associated domain; Region: CorC_HlyC; smart01091
298386009115	S-ribosylhomocysteinase; Provisional; Region: PRK02260
298386009116	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
298386009117	N-acetyl-D-glucosamine binding site [chemical binding]; other site
298386009118	catalytic residue [active]
298386009119	glutamate--cysteine ligase; Provisional; Region: PRK02107
298386009120	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
298386009121	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
298386009122	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
298386009123	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
298386009124	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
298386009125	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
298386009126	Predicted membrane protein [Function unknown]; Region: COG1238
298386009127	Na+-transporting methylmalonyl-CoA/oxaloacetate decarboxylase, beta subunit [Energy production and conversion]; Region: OadB; COG1883
298386009128	oxaloacetate decarboxylase; Provisional; Region: PRK14040
298386009129	Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937
298386009130	active site
298386009131	catalytic residues [active]
298386009132	metal binding site [ion binding]; metal-binding site
298386009133	homodimer binding site [polypeptide binding]; other site
298386009134	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
298386009135	carboxyltransferase (CT) interaction site; other site
298386009136	biotinylation site [posttranslational modification]; other site
298386009137	oxaloacetate decarboxylase subunit gamma; Provisional; Region: PRK03814
298386009138	carbon storage regulator; Provisional; Region: PRK01712
298386009139	aspartate kinase; Validated; Region: PRK08841
298386009140	AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261
298386009141	putative nucleotide binding site [chemical binding]; other site
298386009142	putative catalytic residues [active]
298386009143	putative Mg ion binding site [ion binding]; other site
298386009144	putative aspartate binding site [chemical binding]; other site
298386009145	alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252
298386009146	Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673
298386009147	motif 1; other site
298386009148	active site
298386009149	motif 2; other site
298386009150	motif 3; other site
298386009151	Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863
298386009152	DHHA1 domain; Region: DHHA1; pfam02272
298386009153	recombinase A; Provisional; Region: recA; PRK09354
298386009154	RecA is a  bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response.  RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983
298386009155	hexamer interface [polypeptide binding]; other site
298386009156	Walker A motif; other site
298386009157	ATP binding site [chemical binding]; other site
298386009158	Walker B motif; other site
298386009159	Competence-damaged protein; Region: CinA; cl00666
298386009160	DNA mismatch repair protein MutS; Provisional; Region: PRK05399
298386009161	MutS domain I; Region: MutS_I; pfam01624
298386009162	MutS domain II; Region: MutS_II; pfam05188
298386009163	MutS domain III; Region: MutS_III; pfam05192
298386009164	ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284
298386009165	Walker A/P-loop; other site
298386009166	ATP binding site [chemical binding]; other site
298386009167	Q-loop/lid; other site
298386009168	ABC transporter signature motif; other site
298386009169	Walker B; other site
298386009170	D-loop; other site
298386009171	H-loop/switch region; other site
298386009172	RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394
298386009173	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
298386009174	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298386009175	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
298386009176	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
298386009177	DNA binding residues [nucleotide binding]
298386009178	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
298386009179	Peptidase family M23; Region: Peptidase_M23; pfam01551
298386009180	protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312
298386009181	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298386009182	S-adenosylmethionine binding site [chemical binding]; other site
298386009183	5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346
298386009184	tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984
298386009185	Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575
298386009186	Permutation of conserved domain; other site
298386009187	active site
298386009188	Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130
298386009189	MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554
298386009190	homotrimer interaction site [polypeptide binding]; other site
298386009191	zinc binding site [ion binding]; other site
298386009192	CDP-binding sites; other site
298386009193	CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516
298386009194	substrate binding site; other site
298386009195	dimer interface; other site
298386009196	Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919
298386009197	cell division protein FtsB; Reviewed; Region: ftsB; PRK00888
298386009198	enolase; Provisional; Region: eno; PRK00077
298386009199	Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313
298386009200	dimer interface [polypeptide binding]; other site
298386009201	metal binding site [ion binding]; metal-binding site
298386009202	substrate binding pocket [chemical binding]; other site
298386009203	CTP synthetase; Validated; Region: pyrG; PRK05380
298386009204	CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113
298386009205	Catalytic site [active]
298386009206	active site
298386009207	UTP binding site [chemical binding]; other site
298386009208	Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746
298386009209	active site
298386009210	putative oxyanion hole; other site
298386009211	catalytic triad [active]
298386009212	nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562
298386009213	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528
298386009214	homodimer interface [polypeptide binding]; other site
298386009215	metal binding site [ion binding]; metal-binding site
298386009216	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529
298386009217	homodimer interface [polypeptide binding]; other site
298386009218	active site
298386009219	putative chemical substrate binding site [chemical binding]; other site
298386009220	metal binding site [ion binding]; metal-binding site
298386009221	(p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872
298386009222	HD domain; Region: HD_4; pfam13328
298386009223	Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399
298386009224	synthetase active site [active]
298386009225	NTP binding site [chemical binding]; other site
298386009226	metal binding site [ion binding]; metal-binding site
298386009227	TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668
298386009228	ACT  domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876
298386009229	23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168
298386009230	TRAM domain; Region: TRAM; pfam01938
298386009231	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298386009232	S-adenosylmethionine binding site [chemical binding]; other site
298386009233	hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107
298386009234	Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984
298386009235	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298386009236	dimerization interface [polypeptide binding]; other site
298386009237	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298386009238	dimer interface [polypeptide binding]; other site
298386009239	phosphorylation site [posttranslational modification]
298386009240	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386009241	ATP binding site [chemical binding]; other site
298386009242	Mg2+ binding site [ion binding]; other site
298386009243	G-X-G motif; other site
298386009244	Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999
298386009245	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386009246	active site
298386009247	phosphorylation site [posttranslational modification]
298386009248	intermolecular recognition site; other site
298386009249	dimerization interface [polypeptide binding]; other site
298386009250	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
298386009251	putative binding surface; other site
298386009252	active site
298386009253	4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070
298386009254	Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003
298386009255	active site
298386009256	hydrophilic channel; other site
298386009257	dimerization interface [polypeptide binding]; other site
298386009258	catalytic residues [active]
298386009259	active site lid [active]
298386009260	DNA repair protein RecO; Reviewed; Region: recO; PRK00085
298386009261	Recombination protein O N terminal; Region: RecO_N; pfam11967
298386009262	Recombination protein O C terminal; Region: RecO_C; pfam02565
298386009263	GTPase Era; Reviewed; Region: era; PRK00089
298386009264	E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163
298386009265	G1 box; other site
298386009266	GTP/Mg2+ binding site [chemical binding]; other site
298386009267	Switch I region; other site
298386009268	G2 box; other site
298386009269	Switch II region; other site
298386009270	G3 box; other site
298386009271	G4 box; other site
298386009272	G5 box; other site
298386009273	KH domain; Region: KH_2; pfam07650
298386009274	ribonuclease III; Reviewed; Region: rnc; PRK00102
298386009275	RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593
298386009276	dimerization interface [polypeptide binding]; other site
298386009277	active site
298386009278	metal binding site [ion binding]; metal-binding site
298386009279	Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048
298386009280	dsRNA binding site [nucleotide binding]; other site
298386009281	signal peptidase I; Provisional; Region: PRK10861
298386009282	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
298386009283	Catalytic site [active]
298386009284	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
298386009285	GTP-binding protein LepA; Provisional; Region: PRK05433
298386009286	LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890
298386009287	G1 box; other site
298386009288	putative GEF interaction site [polypeptide binding]; other site
298386009289	GTP/Mg2+ binding site [chemical binding]; other site
298386009290	Switch I region; other site
298386009291	G2 box; other site
298386009292	G3 box; other site
298386009293	Switch II region; other site
298386009294	G4 box; other site
298386009295	G5 box; other site
298386009296	lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699
298386009297	lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane.   LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709
298386009298	GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421
298386009299	Positive regulator of sigma(E), RseC/MucC; Region: RseC_MucC; pfam04246
298386009300	anti-sigma E factor; Provisional; Region: rseB; PRK09455
298386009301	MucB/RseB family; Region: MucB_RseB; pfam03888
298386009302	Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872
298386009303	Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873
298386009304	RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939
298386009305	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298386009306	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
298386009307	DNA binding residues [nucleotide binding]
298386009308	L-aspartate oxidase; Provisional; Region: PRK09077
298386009309	L-aspartate oxidase; Provisional; Region: PRK06175
298386009310	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
298386009311	Uncharacterized conserved protein [Function unknown]; Region: COG2938
298386009312	putative global regulator; Reviewed; Region: PRK09559
298386009313	folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317
298386009314	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
298386009315	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
298386009316	putative deacylase active site [active]
298386009317	Uncharacterized conserved protein [Function unknown]; Region: COG4104
298386009318	A nuclease family of the HNH/ENDO VII superfamily with conserved AHH; Region: AHH; pfam14412
298386009319	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386009320	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386009321	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386009322	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator similar to DntR, which is involved in the catabolism of dinitrotoluene; contains the type 2 periplasmic binding fold; Region: PBP2_DntR_like_2; cd08464
298386009323	putative substrate binding pocket [chemical binding]; other site
298386009324	putative dimerization interface [polypeptide binding]; other site
298386009325	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2991
298386009326	This uncharacterized conserved protein belongs to a family of iron-molybdenum cluster-binding proteins that includes NifX, NifB, and NifY, all of which are involved in the synthesis of an iron-molybdenum cofactor (FeMo-co) that binds the active site of...; Region: MTH1175; cd00851
298386009327	Predicted DNA-binding proteins [General function prediction only]; Region: COG1342
298386009328	DNA binding residues [nucleotide binding]
298386009329	Protein of unknown function (DUF1107); Region: DUF1107; pfam06526
298386009330	glycine cleavage system protein H; Provisional; Region: PRK13380
298386009331	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
298386009332	lipoyl attachment site [posttranslational modification]; other site
298386009333	2-octaprenyl-6-methoxyphenol hydroxylase; Validated; Region: PRK08850
298386009334	Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988
298386009335	2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732
298386009336	2-polyprenyl-6-methoxyphenol 4-hydroxylase; Region: UbiH; TIGR01984
298386009337	hypothetical protein; Reviewed; Region: PRK01736
298386009338	Cell division protein ZapA; Region: ZapA; cl01146
298386009339	5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360
298386009340	5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812
298386009341	RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398
298386009342	tetramer (dimer of dimers) interface [polypeptide binding]; other site
298386009343	active site
298386009344	dimer interface [polypeptide binding]; other site
298386009345	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
298386009346	NAD binding site [chemical binding]; other site
298386009347	Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240
298386009348	C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901
298386009349	L-serine binding site [chemical binding]; other site
298386009350	ACT domain interface; other site
298386009351	Uncharacterized conserved protein [Function unknown]; Region: COG2968
298386009352	oxidative stress defense protein; Provisional; Region: PRK11087
298386009353	chromosome replication initiation inhibitor protein; Validated; Region: PRK03635
298386009354	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386009355	The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428
298386009356	putative dimerization interface [polypeptide binding]; other site
298386009357	Lysine efflux permease [General function prediction only]; Region: COG1279
298386009358	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
298386009359	putative deacylase active site [active]
298386009360	mechanosensitive channel MscS; Provisional; Region: PRK10334
298386009361	Conserved TM helix; Region: TM_helix; pfam05552
298386009362	Mechanosensitive ion channel; Region: MS_channel; pfam00924
298386009363	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
298386009364	Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946
298386009365	active site
298386009366	intersubunit interface [polypeptide binding]; other site
298386009367	zinc binding site [ion binding]; other site
298386009368	Na+ binding site [ion binding]; other site
298386009369	Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318
298386009370	Phosphoglycerate kinase; Region: PGK; pfam00162
298386009371	substrate binding site [chemical binding]; other site
298386009372	hinge regions; other site
298386009373	ADP binding site [chemical binding]; other site
298386009374	catalytic site [active]
298386009375	erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535
298386009376	Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846
298386009377	Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800
298386009378	transketolase; Reviewed; Region: PRK12753
298386009379	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
298386009380	TPP-binding site [chemical binding]; other site
298386009381	dimer interface [polypeptide binding]; other site
298386009382	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
298386009383	PYR/PP interface [polypeptide binding]; other site
298386009384	dimer interface [polypeptide binding]; other site
298386009385	TPP binding site [chemical binding]; other site
298386009386	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
298386009387	S-adenosylmethionine synthetase; Validated; Region: PRK05250
298386009388	S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438
298386009389	S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772
298386009390	S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773
298386009391	hypothetical protein; Provisional; Region: PRK04860
298386009392	Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091
298386009393	Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356
298386009394	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385
298386009395	RNA methyltransferase, RsmE family; Region: TIGR00046
298386009396	glutathione synthetase; Provisional; Region: PRK05246
298386009397	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
298386009398	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
298386009399	hypothetical protein; Validated; Region: PRK00228
298386009400	Holliday junction resolvase-like protein; Reviewed; Region: PRK00109
298386009401	Tfp pilus assembly protein, ATPase PilU [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilU; COG5008
298386009402	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
298386009403	Walker A motif; other site
298386009404	ATP binding site [chemical binding]; other site
298386009405	Walker B motif; other site
298386009406	Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805
298386009407	Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131
298386009408	Walker A motif; other site
298386009409	ATP binding site [chemical binding]; other site
298386009410	Walker B motif; other site
298386009411	Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824
298386009412	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
298386009413	catalytic residue [active]
298386009414	pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880
298386009415	NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232
298386009416	YGGT family; Region: YGGT; pfam02325
298386009417	hypothetical protein; Validated; Region: PRK05090
298386009418	Domain of unknown function (DUF4426); Region: DUF4426; pfam14467
298386009419	NTPase/HAM1.  This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515
298386009420	active site
298386009421	dimerization interface [polypeptide binding]; other site
298386009422	HemN family oxidoreductase; Provisional; Region: PRK05660
298386009423	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
298386009424	FeS/SAM binding site; other site
298386009425	HemN C-terminal domain; Region: HemN_C; pfam06969
298386009426	Protein of unknown function (DUF2884); Region: DUF2884; pfam11101
298386009427	Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066
298386009428	glutaminase; Provisional; Region: PRK00971
298386009429	tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121
298386009430	endonuclease III; Region: ENDO3c; smart00478
298386009431	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
298386009432	minor groove reading motif; other site
298386009433	helix-hairpin-helix signature motif; other site
298386009434	substrate binding pocket [chemical binding]; other site
298386009435	active site
298386009436	iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525
298386009437	DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread  A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431
298386009438	DNA binding and oxoG recognition site [nucleotide binding]
298386009439	oxidative damage protection protein; Provisional; Region: PRK05408
298386009440	Domain of unknown function (DUF3393); Region: DUF3393; pfam11873
298386009441	murein transglycosylase C; Provisional; Region: mltC; PRK11671
298386009442	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
298386009443	N-acetyl-D-glucosamine binding site [chemical binding]; other site
298386009444	catalytic residue [active]
298386009445	Domain of unknown function (DUF3391); Region: DUF3391; pfam11871
298386009446	c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206
298386009447	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
298386009448	Zn2+ binding site [ion binding]; other site
298386009449	Mg2+ binding site [ion binding]; other site
298386009450	penicillin-binding protein 1B; Region: PBP_1b; TIGR02071
298386009451	Transglycosylase; Region: Transgly; pfam00912
298386009452	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
298386009453	ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664
298386009454	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
298386009455	ATP binding site [chemical binding]; other site
298386009456	putative Mg++ binding site [ion binding]; other site
298386009457	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
298386009458	nucleotide binding region [chemical binding]; other site
298386009459	ATP-binding site [chemical binding]; other site
298386009460	Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847
298386009461	ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482
298386009462	2'-5' RNA ligase [Translation, ribosomal structure and biogenesis]; Region: LigT; COG1514
298386009463	LigT like Phosphoesterase; Region: LigT_PEase; pfam02834
298386009464	putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347
298386009465	Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755
298386009466	glutamyl-queuosine tRNA(Asp) synthetase; Region: queuosine_YadB; TIGR03838
298386009467	active site
298386009468	HIGH motif; other site
298386009469	nucleotide binding site [chemical binding]; other site
298386009470	active site
298386009471	KMSKS motif; other site
298386009472	poly(A) polymerase; Region: pcnB; TIGR01942
298386009473	Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398
298386009474	active site
298386009475	NTP binding site [chemical binding]; other site
298386009476	metal binding triad [ion binding]; metal-binding site
298386009477	Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627
298386009478	Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626
298386009479	7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483
298386009480	catalytic center binding site [active]
298386009481	ATP binding site [chemical binding]; other site
298386009482	Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557
298386009483	oligomerization interface [polypeptide binding]; other site
298386009484	active site
298386009485	metal binding site [ion binding]; metal-binding site
298386009486	pantoate--beta-alanine ligase; Region: panC; TIGR00018
298386009487	Pantoate-beta-alanine ligase; Region: PanC; cd00560
298386009488	active site
298386009489	ATP-binding site [chemical binding]; other site
298386009490	pantoate-binding site; other site
298386009491	HXXH motif; other site
298386009492	inner membrane transport permease; Provisional; Region: PRK15066
298386009493	ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842
298386009494	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
298386009495	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
298386009496	Walker A/P-loop; other site
298386009497	ATP binding site [chemical binding]; other site
298386009498	Q-loop/lid; other site
298386009499	ABC transporter signature motif; other site
298386009500	Walker B; other site
298386009501	D-loop; other site
298386009502	H-loop/switch region; other site
298386009503	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883
298386009504	active site clefts [active]
298386009505	zinc binding site [ion binding]; other site
298386009506	dimer interface [polypeptide binding]; other site
298386009507	Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223
298386009508	active site
298386009509	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298386009510	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298386009511	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
298386009512	ATP-binding cassette domain of the carbohydrate and solute transporters-like; Region: ABC_Carb_Solutes_like; cd03259
298386009513	Walker A/P-loop; other site
298386009514	ATP binding site [chemical binding]; other site
298386009515	Q-loop/lid; other site
298386009516	ABC transporter signature motif; other site
298386009517	Walker B; other site
298386009518	D-loop; other site
298386009519	H-loop/switch region; other site
298386009520	TOBE domain; Region: TOBE_2; pfam08402
298386009521	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
298386009522	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386009523	dimer interface [polypeptide binding]; other site
298386009524	conserved gate region; other site
298386009525	putative PBP binding loops; other site
298386009526	ABC-ATPase subunit interface; other site
298386009527	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
298386009528	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
298386009529	probable ammonium transporter, marine subtype; Region: marine_trans_1; TIGR03644
298386009530	Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347
298386009531	Nitrogen regulatory protein P-II; Region: P-II; smart00938
298386009532	Uncharacterized protein family (UPF0231); Region: UPF0231; pfam06062
298386009533	Sugar diacid utilization regulator [Transcription / Signal transduction mechanisms]; Region: CdaR; COG3835
298386009534	Putative sugar diacid recognition; Region: Diacid_rec; pfam05651
298386009535	PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556
298386009536	H+/gluconate symporter and related permeases [Carbohydrate transport and metabolism / Amino acid transport and metabolism]; Region: GntT; COG2610
298386009537	fructuronate transporter; Provisional; Region: PRK10034; cl15264
298386009538	Na+-H+ antiporter family; Region: Na_H_antiport_2; pfam13726
298386009539	Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929
298386009540	bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238
298386009541	Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576
298386009542	substrate binding site [chemical binding]; other site
298386009543	Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581
298386009544	substrate binding site [chemical binding]; other site
298386009545	ligand binding site [chemical binding]; other site
298386009546	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
298386009547	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
298386009548	nucleophile elbow; other site
298386009549	Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729
298386009550	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
298386009551	Cache domain; Region: Cache_1; pfam02743
298386009552	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298386009553	dimerization interface [polypeptide binding]; other site
298386009554	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
298386009555	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
298386009556	dimer interface [polypeptide binding]; other site
298386009557	putative CheW interface [polypeptide binding]; other site
298386009558	dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467
298386009559	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
298386009560	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
298386009561	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
298386009562	pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854
298386009563	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
298386009564	E3 interaction surface; other site
298386009565	lipoyl attachment site [posttranslational modification]; other site
298386009566	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
298386009567	E3 interaction surface; other site
298386009568	lipoyl attachment site [posttranslational modification]; other site
298386009569	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
298386009570	E3 interaction surface; other site
298386009571	lipoyl attachment site [posttranslational modification]; other site
298386009572	e3 binding domain; Region: E3_binding; pfam02817
298386009573	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
298386009574	pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405
298386009575	Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017
298386009576	dimer interface [polypeptide binding]; other site
298386009577	TPP-binding site [chemical binding]; other site
298386009578	Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410
298386009579	transcriptional regulator PdhR; Reviewed; Region: pdhR; PRK09464
298386009580	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298386009581	DNA-binding site [nucleotide binding]; DNA binding site
298386009582	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
298386009583	N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023
298386009584	Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583
298386009585	amidase catalytic site [active]
298386009586	substrate binding site [chemical binding]; other site
298386009587	Zn binding residues [ion binding]; other site
298386009588	quinolinate phosphoribosyltransferase; Validated; Region: PRK09016
298386009589	Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572
298386009590	dimerization interface [polypeptide binding]; other site
298386009591	active site
298386009592	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
298386009593	Pilin (bacterial filament); Region: Pilin; pfam00114
298386009594	type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538
298386009595	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
298386009596	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
298386009597	Walker A motif; other site
298386009598	ATP binding site [chemical binding]; other site
298386009599	Walker B motif; other site
298386009600	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
298386009601	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
298386009602	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
298386009603	Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989
298386009604	Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750
298386009605	Type IV leader peptidase family; Region: Peptidase_A24; pfam01478
298386009606	Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237
298386009607	Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022
298386009608	CoA-binding site [chemical binding]; other site
298386009609	ATP-binding [chemical binding]; other site
298386009610	hypothetical protein; Provisional; Region: PRK05287
298386009611	DNA gyrase inhibitor; Reviewed; Region: PRK00418
298386009612	The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425
298386009613	active site
298386009614	8-oxo-dGMP binding site [chemical binding]; other site
298386009615	nudix motif; other site
298386009616	metal binding site [ion binding]; metal-binding site
298386009617	preprotein translocase subunit SecA; Reviewed; Region: PRK12904
298386009618	DEAD/DEAH box helicase; Region: DEAD; pfam00270
298386009619	SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958
298386009620	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cl17351
298386009621	nucleotide binding region [chemical binding]; other site
298386009622	SEC-C motif; Region: SEC-C; pfam02810
298386009623	Protein of unknown function (DUF721); Region: DUF721; cl02324
298386009624	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186
298386009625	UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331
298386009626	cell division protein FtsZ; Validated; Region: PRK09330
298386009627	FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes.  FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201
298386009628	nucleotide binding site [chemical binding]; other site
298386009629	SulA interaction site; other site
298386009630	cell division protein FtsA; Reviewed; Region: ftsA; PRK09472
298386009631	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
298386009632	nucleotide binding site [chemical binding]; other site
298386009633	Cell division protein FtsA; Region: FtsA; pfam14450
298386009634	Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589
298386009635	POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478
298386009636	Cell division protein FtsQ; Region: FtsQ; pfam03799
298386009637	UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421
298386009638	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
298386009639	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
298386009640	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
298386009641	undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726
298386009642	MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785
298386009643	active site
298386009644	homodimer interface [polypeptide binding]; other site
298386009645	Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511
298386009646	UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK04663
298386009647	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
298386009648	phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108
298386009649	Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852
298386009650	Mg++ binding site [ion binding]; other site
298386009651	putative catalytic motif [active]
298386009652	putative substrate binding site [chemical binding]; other site
298386009653	UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773
298386009654	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
298386009655	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
298386009656	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
298386009657	UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139
298386009658	Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225
298386009659	Mur ligase middle domain; Region: Mur_ligase_M; pfam08245
298386009660	Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875
298386009661	peptidoglycan synthase FtsI; Provisional; Region: PRK15105
298386009662	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
298386009663	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
298386009664	Cell division protein FtsL; Region: FtsL; pfam04999
298386009665	MraW methylase family; Region: Methyltransf_5; pfam01795
298386009666	16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050
298386009667	SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994
298386009668	Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648
298386009669	putative SAM binding site [chemical binding]; other site
298386009670	putative homodimer interface [polypeptide binding]; other site
298386009671	Putative lipoprotein [General function prediction only]; Region: LppC; COG3107
298386009672	Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339
298386009673	putative ligand binding site [chemical binding]; other site
298386009674	hypothetical protein; Reviewed; Region: PRK12497
298386009675	Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006
298386009676	dimer interface [polypeptide binding]; other site
298386009677	active site
298386009678	BON domain; Region: BON; pfam04972
298386009679	BON domain; Region: BON; pfam04972
298386009680	ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798
298386009681	stringent starvation protein A; Provisional; Region: sspA; PRK09481
298386009682	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
298386009683	C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186
298386009684	dimer interface [polypeptide binding]; other site
298386009685	N-terminal domain interface [polypeptide binding]; other site
298386009686	Cytochrome c1 [Energy production and conversion]; Region: CYT1; COG2857
298386009687	Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290
298386009688	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cd00284
298386009689	Qi binding site; other site
298386009690	intrachain domain interface; other site
298386009691	interchain domain interface [polypeptide binding]; other site
298386009692	heme bH binding site [chemical binding]; other site
298386009693	heme bL binding site [chemical binding]; other site
298386009694	Qo binding site; other site
298386009695	Cytochrome b(C-terminus)/b6/petD:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cd00290
298386009696	interchain domain interface [polypeptide binding]; other site
298386009697	intrachain domain interface; other site
298386009698	Qi binding site; other site
298386009699	Qo binding site; other site
298386009700	Ubiquitinol-cytochrome C reductase Fe-S subunit TAT signal; Region: UCR_Fe-S_N; pfam10399
298386009701	ubiquinol-cytochrome c reductase, iron-sulfur subunit; Region: Rieske_proteo; TIGR01416
298386009702	Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including...; Region: Rieske_cytochrome_bc1; cd03470
298386009703	[2Fe-2S] cluster binding site [ion binding]; other site
298386009704	30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132
298386009705	Ribosomal protein L13.  Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392
298386009706	23S rRNA interface [nucleotide binding]; other site
298386009707	L3 interface [polypeptide binding]; other site
298386009708	Predicted ATPase [General function prediction only]; Region: COG1485
298386009709	hypothetical protein; Provisional; Region: PRK11677
298386009710	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105
298386009711	serine endoprotease; Provisional; Region: PRK10942
298386009712	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
298386009713	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
298386009714	protein binding site [polypeptide binding]; other site
298386009715	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
298386009716	periplasmic serine pepetdase DegS; Region: protease_degS; TIGR02038
298386009717	Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365
298386009718	PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987
298386009719	protein binding site [polypeptide binding]; other site
298386009720	UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072
298386009721	UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555
298386009722	hinge; other site
298386009723	active site
298386009724	Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007
298386009725	Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043
298386009726	anti sigma factor interaction site; other site
298386009727	regulatory phosphorylation site [posttranslational modification]; other site
298386009728	Toluene tolerance, Ttg2; Region: Tol_Tol_Ttg2; cl01074
298386009729	ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463
298386009730	mce related protein; Region: MCE; pfam02470
298386009731	ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767
298386009732	conserved hypothetical integral membrane protein; Region: TIGR00056
298386009733	putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831
298386009734	ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261
298386009735	Walker A/P-loop; other site
298386009736	ATP binding site [chemical binding]; other site
298386009737	Q-loop/lid; other site
298386009738	ABC transporter signature motif; other site
298386009739	Walker B; other site
298386009740	D-loop; other site
298386009741	H-loop/switch region; other site
298386009742	putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734
298386009743	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
298386009744	Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699
298386009745	D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892
298386009746	KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014
298386009747	putative active site [active]
298386009748	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein.  These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604
298386009749	3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484
298386009750	HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662
298386009751	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3117
298386009752	Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835
298386009753	OstA-like protein; Region: OstA; cl00844
298386009754	lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002
298386009755	ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137
298386009756	ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218
298386009757	Walker A/P-loop; other site
298386009758	ATP binding site [chemical binding]; other site
298386009759	Q-loop/lid; other site
298386009760	ABC transporter signature motif; other site
298386009761	Walker B; other site
298386009762	D-loop; other site
298386009763	H-loop/switch region; other site
298386009764	RNA polymerase factor sigma-54; Reviewed; Region: PRK05932
298386009765	Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309
298386009766	Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963
298386009767	Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552
298386009768	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
298386009769	30S subunit binding site; other site
298386009770	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
298386009771	active site
298386009772	phosphorylation site [posttranslational modification]
298386009773	glmZ(sRNA)-inactivating NTPase; Provisional; Region: PRK05416
298386009774	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
298386009775	dimerization domain swap beta strand [polypeptide binding]; other site
298386009776	regulatory protein interface [polypeptide binding]; other site
298386009777	active site
298386009778	regulatory phosphorylation site [posttranslational modification]; other site
298386009779	Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239
298386009780	MgtE intracellular N domain; Region: MgtE_N; smart00924
298386009781	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE.  MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606
298386009782	Divalent cation transporter; Region: MgtE; pfam01769
298386009783	peptidase PmbA; Provisional; Region: PRK11040
298386009784	hypothetical protein; Provisional; Region: PRK05255
298386009785	protease TldD; Provisional; Region: tldD; PRK10735
298386009786	nitrilase; Region: PLN02798
298386009787	Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572
298386009788	putative active site [active]
298386009789	catalytic triad [active]
298386009790	dimer interface [polypeptide binding]; other site
298386009791	TIGR02099 family protein; Region: TIGR02099
298386009792	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
298386009793	ribonuclease G; Provisional; Region: PRK11712
298386009794	S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453
298386009795	homodimer interface [polypeptide binding]; other site
298386009796	oligonucleotide binding site [chemical binding]; other site
298386009797	Maf-like protein; Region: Maf; pfam02545
298386009798	Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555
298386009799	active site
298386009800	dimer interface [polypeptide binding]; other site
298386009801	rod shape-determining protein MreD; Provisional; Region: PRK11060
298386009802	rod shape-determining protein MreC; Provisional; Region: PRK13922
298386009803	rod shape-determining protein MreC; Region: MreC; pfam04085
298386009804	rod shape-determining protein MreB; Provisional; Region: PRK13927
298386009805	MreB and similar proteins; Region: MreB_like; cd10225
298386009806	nucleotide binding site [chemical binding]; other site
298386009807	Mg binding site [ion binding]; other site
298386009808	putative protofilament interaction site [polypeptide binding]; other site
298386009809	RodZ interaction site [polypeptide binding]; other site
298386009810	Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459
298386009811	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
298386009812	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
298386009813	Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157
298386009814	Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804
298386009815	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
298386009816	Walker A motif; other site
298386009817	ATP binding site [chemical binding]; other site
298386009818	Walker B motif; other site
298386009819	TPR repeat; Region: TPR_11; pfam13414
298386009820	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298386009821	binding surface
298386009822	TPR motif; other site
298386009823	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298386009824	TPR motif; other site
298386009825	binding surface
298386009826	TPR repeat; Region: TPR_11; pfam13414
298386009827	Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267
298386009828	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298386009829	Walker A motif; other site
298386009830	ATP binding site [chemical binding]; other site
298386009831	Walker B motif; other site
298386009832	arginine finger; other site
298386009833	Secretin and TonB N terminus short domain; Region: STN; smart00965
298386009834	Secretin N-terminal domain; Region: Secretin_N_2; pfam07655
298386009835	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
298386009836	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
298386009837	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3883
298386009838	regulatory protein CsrD; Provisional; Region: PRK11059
298386009839	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298386009840	metal binding site [ion binding]; metal-binding site
298386009841	active site
298386009842	I-site; other site
298386009843	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
298386009844	Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629
298386009845	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
298386009846	dimer interface [polypeptide binding]; other site
298386009847	ssDNA binding site [nucleotide binding]; other site
298386009848	tetramer (dimer of dimers) interface [polypeptide binding]; other site
298386009849	Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930
298386009850	excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349
298386009851	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
298386009852	ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270
298386009853	ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271
298386009854	Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307
298386009855	O-Antigen ligase; Region: Wzy_C; pfam04932
298386009856	Domain of unknown function (DUF3366); Region: DUF3366; pfam11846
298386009857	Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451
298386009858	homodimer interface [polypeptide binding]; other site
298386009859	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298386009860	catalytic residue [active]
298386009861	aspartate kinase III; Validated; Region: PRK09084
298386009862	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
298386009863	nucleotide binding site [chemical binding]; other site
298386009864	substrate binding site [chemical binding]; other site
298386009865	ACT domains located C-terminal to the catalytic domain of  the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC-like_1; cd04912
298386009866	dimer interface [polypeptide binding]; other site
298386009867	allosteric regulatory binding pocket; other site
298386009868	ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917
298386009869	dimer interface [polypeptide binding]; other site
298386009870	B12-dependent methionine synthase; Provisional; Region: metH; PRK09490
298386009871	Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646
298386009872	MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH).  Cobalamin-dependent...; Region: MeTr; cd00740
298386009873	substrate binding pocket [chemical binding]; other site
298386009874	B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069
298386009875	B12 binding site [chemical binding]; other site
298386009876	cobalt ligand [ion binding]; other site
298386009877	Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965
298386009878	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
298386009879	Winged helix-turn helix; Region: HTH_33; pfam13592
298386009880	DDE superfamily endonuclease; Region: DDE_3; pfam13358
298386009881	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
298386009882	Homeodomain-like domain; Region: HTH_23; pfam13384
298386009883	Winged helix-turn helix; Region: HTH_29; pfam13551
298386009884	Winged helix-turn helix; Region: HTH_33; pfam13592
298386009885	DDE superfamily endonuclease; Region: DDE_3; pfam13358
298386009886	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
298386009887	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
298386009888	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
298386009889	active site
298386009890	Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027
298386009891	AAA domain; Region: AAA_18; pfam13238
298386009892	ligand-binding site [chemical binding]; other site
298386009893	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
298386009894	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
298386009895	TrkA-C domain; Region: TrkA_C; pfam02080
298386009896	TrkA-C domain; Region: TrkA_C; pfam02080
298386009897	Anion permease ArsB/NhaD.  These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life.  A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221
298386009898	sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124
298386009899	CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166
298386009900	CysD dimerization site [polypeptide binding]; other site
298386009901	G1 box; other site
298386009902	putative GEF interaction site [polypeptide binding]; other site
298386009903	GTP/Mg2+ binding site [chemical binding]; other site
298386009904	Switch I region; other site
298386009905	G2 box; other site
298386009906	G3 box; other site
298386009907	Switch II region; other site
298386009908	G4 box; other site
298386009909	G5 box; other site
298386009910	CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695
298386009911	TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095
298386009912	sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039
298386009913	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
298386009914	Active Sites [active]
298386009915	siroheme synthase; Provisional; Region: cysG; PRK10637
298386009916	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
298386009917	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
298386009918	Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642
298386009919	active site
298386009920	SAM binding site [chemical binding]; other site
298386009921	homodimer interface [polypeptide binding]; other site
298386009922	bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420
298386009923	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
298386009924	active site
298386009925	metal binding site [ion binding]; metal-binding site
298386009926	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
298386009927	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
298386009928	cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664
298386009929	ligand binding site [chemical binding]; other site
298386009930	flexible hinge region; other site
298386009931	Autoinducer synthetase; Region: Autoind_synth; cl17404
298386009932	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298386009933	Coenzyme A binding pocket [chemical binding]; other site
298386009934	Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225
298386009935	peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570
298386009936	Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346
298386009937	FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254
298386009938	Protein of unknown function VcgC/VcgE (DUF2780); Region: DUF2780; pfam11075
298386009939	3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175
298386009940	This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713
298386009941	Active Sites [active]
298386009942	sulfite reductase subunit beta; Provisional; Region: PRK13504
298386009943	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
298386009944	Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460
298386009945	sulfite reductase [NADPH] flavoprotein, alpha-component; Region: cysJ; TIGR01931
298386009946	Flavodoxin; Region: Flavodoxin_1; pfam00258
298386009947	Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199
298386009948	FAD binding pocket [chemical binding]; other site
298386009949	FAD binding motif [chemical binding]; other site
298386009950	catalytic residues [active]
298386009951	NAD binding pocket [chemical binding]; other site
298386009952	phosphate binding motif [ion binding]; other site
298386009953	beta-alpha-beta structure motif; other site
298386009954	outer membrane protein; Region: OMP_w_GlyGly; TIGR04219
298386009955	tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815
298386009956	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
298386009957	FMN binding site [chemical binding]; other site
298386009958	active site
298386009959	catalytic residues [active]
298386009960	substrate binding site [chemical binding]; other site
298386009961	Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153
298386009962	metal binding site 2 [ion binding]; metal-binding site
298386009963	putative DNA binding helix; other site
298386009964	metal binding site 1 [ion binding]; metal-binding site
298386009965	dimer interface [polypeptide binding]; other site
298386009966	structural Zn2+ binding site [ion binding]; other site
298386009967	Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406
298386009968	Chemotaxis phosphatase CheX; Region: CheX; pfam13690
298386009969	glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179
298386009970	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015
298386009971	active site
298386009972	dimer interface [polypeptide binding]; other site
298386009973	Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016
298386009974	dimer interface [polypeptide binding]; other site
298386009975	active site
298386009976	Surface antigen; Region: Bac_surface_Ag; pfam01103
298386009977	alanine racemase; Reviewed; Region: alr; PRK00053
298386009978	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827
298386009979	active site
298386009980	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
298386009981	substrate binding site [chemical binding]; other site
298386009982	catalytic residues [active]
298386009983	dimer interface [polypeptide binding]; other site
298386009984	replicative DNA helicase; Provisional; Region: PRK08840
298386009985	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
298386009986	DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the  chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984
298386009987	Walker A motif; other site
298386009988	ATP binding site [chemical binding]; other site
298386009989	Walker B motif; other site
298386009990	DNA binding loops [nucleotide binding]
298386009991	Protein of unknown function, DUF481; Region: DUF481; pfam04338
298386009992	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464
298386009993	Transposase; Region: DDE_Tnp_ISL3; pfam01610
298386009994	50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137
298386009995	Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281
298386009996	Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948
298386009997	30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391
298386009998	SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496
298386009999	dimer interface [polypeptide binding]; other site
298386010000	ssDNA binding site [nucleotide binding]; other site
298386010001	tetramer (dimer of dimers) interface [polypeptide binding]; other site
298386010002	30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453
298386010003	23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181
298386010004	RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032
298386010005	SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588
298386010006	exoribonuclease R; Provisional; Region: PRK11642
298386010007	Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461
298386010008	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
298386010009	RNB domain; Region: RNB; pfam00773
298386010010	S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471
298386010011	RNA binding site [nucleotide binding]; other site
298386010012	transcriptional repressor NsrR; Provisional; Region: PRK11014
298386010013	Rrf2 family protein; Region: rrf2_super; TIGR00738
298386010014	bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289
298386010015	Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040
298386010016	heme-binding site [chemical binding]; other site
298386010017	FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184
298386010018	FAD binding pocket [chemical binding]; other site
298386010019	FAD binding motif [chemical binding]; other site
298386010020	phosphate binding motif [ion binding]; other site
298386010021	beta-alpha-beta structure motif; other site
298386010022	NAD binding pocket [chemical binding]; other site
298386010023	Heme binding  pocket [chemical binding]; other site
298386010024	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
298386010025	Sel1 repeat; Region: Sel1; cl02723
298386010026	Sel1-like repeats; Region: SEL1; smart00671
298386010027	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
298386010028	Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108
298386010029	GDP-binding site [chemical binding]; other site
298386010030	ACT binding site; other site
298386010031	IMP binding site; other site
298386010032	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242
298386010033	FtsH protease regulator HflC; Provisional; Region: PRK11029
298386010034	Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405
298386010035	FtsH protease regulator HflK; Provisional; Region: PRK10930
298386010036	Bacterial membrane protein N terminal; Region: HflK_N; pfam12221
298386010037	Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404
298386010038	GTPase HflX; Provisional; Region: PRK11058
298386010039	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
298386010040	HflX GTPase family; Region: HflX; cd01878
298386010041	G1 box; other site
298386010042	GTP/Mg2+ binding site [chemical binding]; other site
298386010043	Switch I region; other site
298386010044	G2 box; other site
298386010045	G3 box; other site
298386010046	Switch II region; other site
298386010047	G4 box; other site
298386010048	G5 box; other site
298386010049	bacterial Hfq-like; Region: Hfq; cd01716
298386010050	hexamer interface [polypeptide binding]; other site
298386010051	Sm1 motif; other site
298386010052	RNA binding site [nucleotide binding]; other site
298386010053	Sm2 motif; other site
298386010054	tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091
298386010055	tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324
298386010056	DNA mismatch repair protein MutL; Region: mutl; TIGR00585
298386010057	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386010058	ATP binding site [chemical binding]; other site
298386010059	Mg2+ binding site [ion binding]; other site
298386010060	G-X-G motif; other site
298386010061	MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL.  EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family.  This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482
298386010062	ATP binding site [chemical binding]; other site
298386010063	MutL C terminal dimerisation domain; Region: MutL_C; pfam08676
298386010064	N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431
298386010065	AMIN domain; Region: AMIN; pfam11741
298386010066	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
298386010067	active site
298386010068	metal binding site [ion binding]; metal-binding site
298386010069	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
298386010070	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
298386010071	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
298386010072	FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388
298386010073	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
298386010074	Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520
298386010075	putative carbohydrate kinase; Provisional; Region: PRK10565
298386010076	Uncharacterized conserved protein [Function unknown]; Region: COG0062
298386010077	B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171
298386010078	putative substrate binding site [chemical binding]; other site
298386010079	putative ATP binding site [chemical binding]; other site
298386010080	epoxyqueuosine reductase; Region: TIGR00276
298386010081	Domain of unknown function (DUF1730); Region: DUF1730; pfam08331
298386010082	DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135
298386010083	catalytic site [active]
298386010084	putative active site [active]
298386010085	putative substrate binding site [chemical binding]; other site
298386010086	dimer interface [polypeptide binding]; other site
298386010087	GTPase RsgA; Reviewed; Region: PRK12288
298386010088	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
298386010089	RNA binding site [nucleotide binding]; other site
298386010090	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
298386010091	GTPase/Zn-binding domain interface [polypeptide binding]; other site
298386010092	GTP/Mg2+ binding site [chemical binding]; other site
298386010093	G4 box; other site
298386010094	G5 box; other site
298386010095	G1 box; other site
298386010096	Switch I region; other site
298386010097	G2 box; other site
298386010098	G3 box; other site
298386010099	Switch II region; other site
298386010100	phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044
298386010101	Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471
298386010102	Permease SLC13 (solute carrier 13).  The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115
298386010103	transmembrane helices; other site
298386010104	Cache domain; Region: Cache_1; pfam02743
298386010105	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298386010106	dimerization interface [polypeptide binding]; other site
298386010107	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
298386010108	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
298386010109	dimer interface [polypeptide binding]; other site
298386010110	putative CheW interface [polypeptide binding]; other site
298386010111	Carbonic anhydrase [Inorganic ion transport and metabolism]; Region: Cah; COG3338
298386010112	Carbonic anhydrase alpha, prokaryotic-like subfamily. Carbonic anhydrases (CAs) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism: a nucleophilic attack of a zinc-bound hydroxide ion on carbon...; Region: alpha_CA_prokaryotic_like; cd03124
298386010113	active site
298386010114	zinc binding site [ion binding]; other site
298386010115	poxB regulator PoxA; Provisional; Region: PRK09350
298386010116	Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA.   PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268
298386010117	motif 1; other site
298386010118	dimer interface [polypeptide binding]; other site
298386010119	active site
298386010120	motif 2; other site
298386010121	motif 3; other site
298386010122	fumarate reductase flavoprotein subunit; Validated; Region: PRK09231
298386010123	L-aspartate oxidase; Provisional; Region: PRK06175
298386010124	Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910
298386010125	fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385
298386010126	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
298386010127	catalytic loop [active]
298386010128	iron binding site [ion binding]; other site
298386010129	Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C;  QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546
298386010130	D-subunit interface [polypeptide binding]; other site
298386010131	Iron-sulfur protein interface; other site
298386010132	proximal quinone binding site [chemical binding]; other site
298386010133	distal quinone binding site [chemical binding]; other site
298386010134	Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547
298386010135	Iron-sulfur protein interface; other site
298386010136	proximal quinone binding site [chemical binding]; other site
298386010137	C-subunit interface; other site
298386010138	distal quinone binding site; other site
298386010139	elongation factor P; Validated; Region: PRK00529
298386010140	Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207
298386010141	S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470
298386010142	RNA binding site [nucleotide binding]; other site
298386010143	S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794
298386010144	RNA binding site [nucleotide binding]; other site
298386010145	Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509
298386010146	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
298386010147	FeS/SAM binding site; other site
298386010148	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298386010149	dimerization interface [polypeptide binding]; other site
298386010150	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
298386010151	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
298386010152	dimer interface [polypeptide binding]; other site
298386010153	putative CheW interface [polypeptide binding]; other site
298386010154	alanine racemase; Reviewed; Region: PRK13340
298386010155	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme, Alanine Racemase 2; Region: PLPDE_III_AR2; cd06826
298386010156	active site
298386010157	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
298386010158	dimer interface [polypeptide binding]; other site
298386010159	substrate binding site [chemical binding]; other site
298386010160	catalytic residues [active]
298386010161	ribosomal protein S6 modification protein; Provisional; Region: PRK10446
298386010162	RimK-like ATP-grasp domain; Region: RimK; pfam08443
298386010163	chaperonin GroEL; Reviewed; Region: groEL; PRK12849
298386010164	GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344
298386010165	ring oligomerisation interface [polypeptide binding]; other site
298386010166	ATP/Mg binding site [chemical binding]; other site
298386010167	stacking interactions; other site
298386010168	hinge regions; other site
298386010169	Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320
298386010170	oligomerisation interface [polypeptide binding]; other site
298386010171	mobile loop; other site
298386010172	roof hairpin; other site
298386010173	Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_2; cd13149
298386010174	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
298386010175	phage T7 F exclusion suppressor FxsA; Reviewed; Region: fxsA; PRK11463
298386010176	aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273
298386010177	Aspartase; Region: Aspartase; cd01357
298386010178	active sites [active]
298386010179	tetramer interface [polypeptide binding]; other site
298386010180	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
298386010181	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
298386010182	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386010183	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386010184	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
298386010185	putative effector binding pocket; other site
298386010186	dimerization interface [polypeptide binding]; other site
298386010187	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298386010188	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386010189	active site
298386010190	phosphorylation site [posttranslational modification]
298386010191	intermolecular recognition site; other site
298386010192	dimerization interface [polypeptide binding]; other site
298386010193	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298386010194	DNA binding residues [nucleotide binding]
298386010195	dimerization interface [polypeptide binding]; other site
298386010196	Multiple antibiotic transporter [Intracellular trafficking and secretion]; Region: MarC; COG2095
298386010197	Domain of unknown function (DUF4212); Region: DUF4212; pfam13937
298386010198	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
298386010199	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480
298386010200	Na binding site [ion binding]; other site
298386010201	Na+/proline symporter [Amino acid transport and metabolism / General function prediction only]; Region: PutP; COG0591
298386010202	Na binding site [ion binding]; other site
298386010203	PAS domain; Region: PAS; smart00091
298386010204	PAS fold; Region: PAS_7; pfam12860
298386010205	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298386010206	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298386010207	dimer interface [polypeptide binding]; other site
298386010208	phosphorylation site [posttranslational modification]
298386010209	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386010210	ATP binding site [chemical binding]; other site
298386010211	Mg2+ binding site [ion binding]; other site
298386010212	G-X-G motif; other site
298386010213	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
298386010214	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386010215	active site
298386010216	phosphorylation site [posttranslational modification]
298386010217	intermolecular recognition site; other site
298386010218	dimerization interface [polypeptide binding]; other site
298386010219	putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128
298386010220	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
298386010221	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
298386010222	ligand binding site [chemical binding]; other site
298386010223	flexible hinge region; other site
298386010224	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the bacterial CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain.  Members of CAP_ED, include CAP...; Region: CBS_pair_CAP-ED_DUF294_assoc_bac; cd04589
298386010225	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
298386010226	metal binding triad; other site
298386010227	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
298386010228	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
298386010229	active site
298386010230	catalytic site [active]
298386010231	substrate binding site [chemical binding]; other site
298386010232	acetyl-CoA synthetase; Provisional; Region: PRK00174
298386010233	Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966
298386010234	active site
298386010235	CoA binding site [chemical binding]; other site
298386010236	acyl-activating enzyme (AAE) consensus motif; other site
298386010237	AMP binding site [chemical binding]; other site
298386010238	acetate binding site [chemical binding]; other site
298386010239	Dehydroquinase (DHQase), type II. Dehydroquinase (or 3-dehydroquinate dehydratase) catalyzes the reversible dehydration of 3-dehydroquinate to form 3-dehydroshikimate. This reaction is part of two metabolic pathways: the biosynthetic shikimate pathway...; Region: DHQase_II; cd00466
298386010240	Dehydroquinase class II; Region: DHquinase_II; pfam01220
298386010241	active site
298386010242	trimer interface [polypeptide binding]; other site
298386010243	dimer interface [polypeptide binding]; other site
298386010244	acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302
298386010245	The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850
298386010246	carboxyltransferase (CT) interaction site; other site
298386010247	biotinylation site [posttranslational modification]; other site
298386010248	acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591
298386010249	Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289
298386010250	Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786
298386010251	Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878
298386010252	Protein of unknown function (DUF997); Region: DUF997; pfam06196
298386010253	Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327
298386010254	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
298386010255	Na binding site [ion binding]; other site
298386010256	Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325
298386010257	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298386010258	S-adenosylmethionine binding site [chemical binding]; other site
298386010259	tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415
298386010260	Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801
298386010261	FMN binding site [chemical binding]; other site
298386010262	active site
298386010263	catalytic residues [active]
298386010264	substrate binding site [chemical binding]; other site
298386010265	Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901
298386010266	global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430
298386010267	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
298386010268	Transposase; Region: DEDD_Tnp_IS110; pfam01548
298386010269	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
298386010270	Protein of unknown function (DUF1255); Region: DUF1255; pfam06865
298386010271	rare lipoprotein A; Provisional; Region: PRK10672
298386010272	zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514
298386010273	Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770
298386010274	DNA binding residues [nucleotide binding]
298386010275	dimer interface [polypeptide binding]; other site
298386010276	metal binding site [ion binding]; metal-binding site
298386010277	bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881
298386010278	Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal  ATIC formylase domain that formylates...; Region: IMPCH; cd01421
298386010279	purine monophosphate binding site [chemical binding]; other site
298386010280	dimer interface [polypeptide binding]; other site
298386010281	putative catalytic residues [active]
298386010282	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798
298386010283	AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362
298386010284	phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885
298386010285	Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844
298386010286	Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071
298386010287	Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843
298386010288	Protein of unknown function (DUF1481); Region: DUF1481; pfam07356
298386010289	Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591
298386010290	IHF dimer interface [polypeptide binding]; other site
298386010291	IHF - DNA interface [nucleotide binding]; other site
298386010292	Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253
298386010293	Domain of unknown function DUF21; Region: DUF21; pfam01595
298386010294	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590
298386010295	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
298386010296	Protein of unknown function (DUF416); Region: DUF416; cl01166
298386010297	Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300
298386010298	Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111
298386010299	NAD binding site [chemical binding]; other site
298386010300	ligand binding site [chemical binding]; other site
298386010301	catalytic site [active]
298386010302	Uncharacterized subfamily of Uracil-DNA glycosylases; Region: UDG_like_1; cd10033
298386010303	putative uracil binding site [chemical binding]; other site
298386010304	putative active site [active]
298386010305	methylcobalamin:coenzyme M methyltransferase; Validated; Region: PRK06252
298386010306	Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717
298386010307	substrate binding site [chemical binding]; other site
298386010308	active site
298386010309	NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241
298386010310	NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296
298386010311	NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297
298386010312	NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429
298386010313	putative NADH binding site [chemical binding]; other site
298386010314	putative active site [active]
298386010315	nudix motif; other site
298386010316	putative metal binding site [ion binding]; other site
298386010317	Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ; Region: Rsd_AlgQ; pfam04353
298386010318	RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997
298386010319	DNA-directed RNA polymerase, beta' subunit, predominant form; Region: rpoC_TIGR; TIGR02386
298386010320	RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663
298386010321	RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983
298386010322	RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000
298386010323	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
298386010324	Rpb1 - Rpb6 interaction site [polypeptide binding]; other site
298386010325	Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429
298386010326	Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655
298386010327	DNA binding site [nucleotide binding]
298386010328	Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site
298386010329	DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405
298386010330	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585
298386010331	RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561
298386010332	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
298386010333	RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562
298386010334	RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653
298386010335	RPB3 interaction site [polypeptide binding]; other site
298386010336	RPB1 interaction site [polypeptide binding]; other site
298386010337	RPB11 interaction site [polypeptide binding]; other site
298386010338	RPB10 interaction site [polypeptide binding]; other site
298386010339	Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387
298386010340	core dimer interface [polypeptide binding]; other site
298386010341	peripheral dimer interface [polypeptide binding]; other site
298386010342	L10 interface [polypeptide binding]; other site
298386010343	L11 interface [polypeptide binding]; other site
298386010344	putative EF-Tu interaction site [polypeptide binding]; other site
298386010345	putative EF-G interaction site [polypeptide binding]; other site
298386010346	Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797
298386010347	23S rRNA interface [nucleotide binding]; other site
298386010348	Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site
298386010349	Ribosomal protein L1.  The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA.  In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403
298386010350	mRNA/rRNA interface [nucleotide binding]; other site
298386010351	50S ribosomal protein L11; Validated; Region: rplK; PRK00140
298386010352	Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349
298386010353	23S rRNA interface [nucleotide binding]; other site
298386010354	L7/L12 interface [polypeptide binding]; other site
298386010355	putative thiostrepton binding site; other site
298386010356	L25 interface [polypeptide binding]; other site
298386010357	transcription antitermination protein NusG; Validated; Region: nusG; PRK05609
298386010358	Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891
298386010359	putative homodimer interface [polypeptide binding]; other site
298386010360	NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091
298386010361	heterodimer interface [polypeptide binding]; other site
298386010362	homodimer interface [polypeptide binding]; other site
298386010363	preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740
298386010364	elongation factor Tu; Reviewed; Region: PRK00049
298386010365	Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884
298386010366	G1 box; other site
298386010367	GEF interaction site [polypeptide binding]; other site
298386010368	GTP/Mg2+ binding site [chemical binding]; other site
298386010369	Switch I region; other site
298386010370	G2 box; other site
298386010371	G3 box; other site
298386010372	Switch II region; other site
298386010373	G4 box; other site
298386010374	G5 box; other site
298386010375	EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697
298386010376	Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707
298386010377	Antibiotic Binding Site [chemical binding]; other site
298386010378	Type III pantothenate kinase; Region: Pan_kinase; pfam03309
298386010379	bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886
298386010380	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
298386010381	putative DNA binding site [nucleotide binding]; other site
298386010382	putative Zn2+ binding site [ion binding]; other site
298386010383	Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099
298386010384	Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237
298386010385	UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046
298386010386	FAD binding domain; Region: FAD_binding_4; pfam01565
298386010387	UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873
298386010388	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
298386010389	Coenzyme A binding pocket [chemical binding]; other site
298386010390	phosphatidylserine synthase; Provisional; Region: pssA; PRK09428
298386010391	Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134
298386010392	domain interface [polypeptide binding]; other site
298386010393	putative active site [active]
298386010394	catalytic site [active]
298386010395	Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136
298386010396	domain interface [polypeptide binding]; other site
298386010397	putative active site [active]
298386010398	catalytic site [active]
298386010399	Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011
298386010400	Isochorismatase family; Region: Isochorismatase; pfam00857
298386010401	catalytic triad [active]
298386010402	metal binding site [ion binding]; metal-binding site
298386010403	conserved cis-peptide bond; other site
298386010404	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386010405	RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724
298386010406	RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399
298386010407	glutamate racemase; Provisional; Region: PRK00865
298386010408	This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily  includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which  binds to Adenosine group.  This subfamily; Region: Alpha_ANH_like_IV; cd01994
298386010409	Predicted ATPases of PP-loop superfamily [General function prediction only]; Region: COG2102
298386010410	Ligand Binding Site [chemical binding]; other site
298386010411	Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206
298386010412	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
298386010413	N-terminal plug; other site
298386010414	ligand-binding site [chemical binding]; other site
298386010415	tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031
298386010416	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298386010417	S-adenosylmethionine binding site [chemical binding]; other site
298386010418	hypothetical protein; Provisional; Region: PRK11056
298386010419	DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202
298386010420	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298386010421	soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249
298386010422	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
298386010423	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
298386010424	CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638
298386010425	Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483
298386010426	active site
298386010427	adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762
298386010428	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
298386010429	dimer interface [polypeptide binding]; other site
298386010430	ADP-ribose binding site [chemical binding]; other site
298386010431	active site
298386010432	nudix motif; other site
298386010433	metal binding site [ion binding]; metal-binding site
298386010434	Type II secretion system (T2SS), protein N; Region: T2SN; pfam01203
298386010435	Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612
298386010436	type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709
298386010437	Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134
298386010438	GspL periplasmic domain; Region: GspL_C; pfam12693
298386010439	Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934
298386010440	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
298386010441	type II secretion system protein J; Region: gspJ; TIGR01711
298386010442	Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612
298386010443	type II secretion system protein I; Region: gspI; TIGR01707
298386010444	Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501
298386010445	type II secretion system protein H; Region: typeII_sec_gspH; TIGR01708
298386010446	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
298386010447	type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710
298386010448	Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334
298386010449	type II secretion system protein F; Region: GspF; TIGR02120
298386010450	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
298386010451	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
298386010452	type II secretion system protein E; Region: type_II_gspE; TIGR02533
298386010453	PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129
298386010454	Walker A motif; other site
298386010455	ATP binding site [chemical binding]; other site
298386010456	Walker B motif; other site
298386010457	type II secretion system protein D; Region: type_II_gspD; TIGR02517
298386010458	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
298386010459	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
298386010460	Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958
298386010461	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
298386010462	type II secretion system protein C; Region: typeII_sec_gspC; TIGR01713
298386010463	Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356
298386010464	PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117
298386010465	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
298386010466	RNA binding surface [nucleotide binding]; other site
298386010467	Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114
298386010468	Heat shock protein 33 (Hsp33):  Cytosolic protein that acts as a molecular chaperone under oxidative conditions.  In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498
298386010469	dimerization interface [polypeptide binding]; other site
298386010470	domain crossover interface; other site
298386010471	redox-dependent activation switch; other site
298386010472	Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293
298386010473	Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484
298386010474	active site
298386010475	substrate-binding site [chemical binding]; other site
298386010476	metal-binding site [ion binding]
298386010477	ATP binding site [chemical binding]; other site
298386010478	AsmA family; Region: AsmA; pfam05170
298386010479	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
298386010480	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298386010481	Coenzyme A binding pocket [chemical binding]; other site
298386010482	Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500
298386010483	D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563
298386010484	putative active site [active]
298386010485	dimerization interface [polypeptide binding]; other site
298386010486	putative tRNAtyr binding site [nucleotide binding]; other site
298386010487	hypothetical protein; Reviewed; Region: PRK01637
298386010488	Predicted ATPase [General function prediction only]; Region: COG3911
298386010489	AAA domain; Region: AAA_28; pfam13521
298386010490	Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217
298386010491	Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891
298386010492	G1 box; other site
298386010493	putative GEF interaction site [polypeptide binding]; other site
298386010494	GTP/Mg2+ binding site [chemical binding]; other site
298386010495	Switch I region; other site
298386010496	G2 box; other site
298386010497	G3 box; other site
298386010498	Switch II region; other site
298386010499	G4 box; other site
298386010500	G5 box; other site
298386010501	BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu.  BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691
298386010502	BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants.  BipA is a highly...; Region: BipA_TypA_C; cd03710
298386010503	glutamine synthetase; Provisional; Region: glnA; PRK09469
298386010504	Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951
298386010505	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
298386010506	Domain of unknown function (DUF4124); Region: DUF4124; pfam13511
298386010507	nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073
298386010508	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
298386010509	putative active site [active]
298386010510	heme pocket [chemical binding]; other site
298386010511	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298386010512	dimer interface [polypeptide binding]; other site
298386010513	phosphorylation site [posttranslational modification]
298386010514	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386010515	ATP binding site [chemical binding]; other site
298386010516	Mg2+ binding site [ion binding]; other site
298386010517	G-X-G motif; other site
298386010518	nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923
298386010519	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386010520	active site
298386010521	phosphorylation site [posttranslational modification]
298386010522	intermolecular recognition site; other site
298386010523	dimerization interface [polypeptide binding]; other site
298386010524	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298386010525	Walker A motif; other site
298386010526	ATP binding site [chemical binding]; other site
298386010527	Walker B motif; other site
298386010528	arginine finger; other site
298386010529	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
298386010530	adenosine deaminase; Provisional; Region: PRK09358
298386010531	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
298386010532	active site
298386010533	coproporphyrinogen III oxidase; Provisional; Region: PRK09249
298386010534	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
298386010535	FeS/SAM binding site; other site
298386010536	HemN C-terminal domain; Region: HemN_C; pfam06969
298386010537	Protein of unknown function (DUF2489); Region: DUF2489; pfam10675
298386010538	Der GTPase activator; Provisional; Region: PRK05244
298386010539	Cytochrome c553 [Energy production and conversion]; Region: COG2863
298386010540	Cytochrome c; Region: Cytochrom_C; cl11414
298386010541	YihA (EngB) GTPase family; Region: YihA_EngB; cd01876
298386010542	G1 box; other site
298386010543	GTP/Mg2+ binding site [chemical binding]; other site
298386010544	Switch I region; other site
298386010545	G2 box; other site
298386010546	G3 box; other site
298386010547	Switch II region; other site
298386010548	G4 box; other site
298386010549	G5 box; other site
298386010550	DNA polymerase I; Provisional; Region: PRK05755
298386010551	PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859
298386010552	active site
298386010553	metal binding site 1 [ion binding]; metal-binding site
298386010554	putative 5' ssDNA interaction site; other site
298386010555	metal binding site 3; metal-binding site
298386010556	metal binding site 2 [ion binding]; metal-binding site
298386010557	H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898
298386010558	putative DNA binding site [nucleotide binding]; other site
298386010559	putative metal binding site [ion binding]; other site
298386010560	DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139
298386010561	active site
298386010562	catalytic site [active]
298386010563	substrate binding site [chemical binding]; other site
298386010564	Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637
298386010565	active site
298386010566	DNA binding site [nucleotide binding]
298386010567	catalytic site [active]
298386010568	isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780
298386010569	Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133
298386010570	conserved cys residue [active]
298386010571	putative acetyltransferase; Provisional; Region: PRK03624
298386010572	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298386010573	Coenzyme A binding pocket [chemical binding]; other site
298386010574	hypothetical protein; Provisional; Region: PRK11212
298386010575	Protein of unknown function (DUF3630); Region: DUF3630; pfam12305
298386010576	ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057
298386010577	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
298386010578	ATP binding site [chemical binding]; other site
298386010579	putative Mg++ binding site [ion binding]; other site
298386010580	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
298386010581	nucleotide binding region [chemical binding]; other site
298386010582	ATP-binding site [chemical binding]; other site
298386010583	This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956
298386010584	HRDC domain; Region: HRDC; pfam00570
298386010585	Predicted permeases [General function prediction only]; Region: RarD; COG2962
298386010586	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
298386010587	AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207
298386010588	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298386010589	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298386010590	LysE type translocator; Region: LysE; cl00565
298386010591	Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405
298386010592	Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019
298386010593	DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773
298386010594	Part of AAA domain; Region: AAA_19; pfam13245
298386010595	Family description; Region: UvrD_C_2; pfam13538
298386010596	Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048
298386010597	Predicted integral membrane protein (DUF2282); Region: DUF2282; pfam10048
298386010598	hypothetical protein; Provisional; Region: PRK05409
298386010599	Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836
298386010600	Predicted membrane protein [Function unknown]; Region: COG2259
298386010601	flavin mononucleotide phosphatase; Provisional; Region: PRK10748
298386010602	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
298386010603	motif II; other site
298386010604	Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973
298386010605	XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798
298386010606	active site
298386010607	Int/Topo IB signature motif; other site
298386010608	Protein of unknown function, DUF484; Region: DUF484; cl17449
298386010609	diaminopimelate epimerase; Provisional; Region: dapF; PRK00450
298386010610	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
298386010611	Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678
298386010612	diaminopimelate decarboxylase; Region: lysA; TIGR01048
298386010613	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828
298386010614	active site
298386010615	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
298386010616	substrate binding site [chemical binding]; other site
298386010617	catalytic residues [active]
298386010618	dimer interface [polypeptide binding]; other site
298386010619	Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503
298386010620	putative iron binding site [ion binding]; other site
298386010621	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386010622	adenylate cyclase; Provisional; Region: cyaA; PRK09450
298386010623	Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633
298386010624	Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295
298386010625	porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072
298386010626	Porphobilinogen deaminase, dipyromethane cofactor binding domain; Region: Porphobil_deam; pfam01379
298386010627	Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708
298386010628	Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578
298386010629	uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928
298386010630	active site
298386010631	putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920
298386010632	HemX; Region: HemX; pfam04375
298386010633	Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemY; COG3071
298386010634	HemY protein N-terminus; Region: HemY_N; pfam07219
298386010635	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298386010636	TPR motif; other site
298386010637	binding surface
298386010638	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298386010639	TPR motif; other site
298386010640	binding surface
298386010641	Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517
298386010642	Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011
298386010643	FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202
298386010644	PAS domain S-box; Region: sensory_box; TIGR00229
298386010645	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
298386010646	putative active site [active]
298386010647	heme pocket [chemical binding]; other site
298386010648	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298386010649	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298386010650	metal binding site [ion binding]; metal-binding site
298386010651	active site
298386010652	I-site; other site
298386010653	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
298386010654	DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179
298386010655	AsnC-type helix-turn-helix domain; Region: HTH_AsnC-type; pfam13404
298386010656	AsnC family; Region: AsnC_trans_reg; pfam01037
298386010657	FMN reductase; Validated; Region: fre; PRK08051
298386010658	NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189
298386010659	FAD binding pocket [chemical binding]; other site
298386010660	FAD binding motif [chemical binding]; other site
298386010661	phosphate binding motif [ion binding]; other site
298386010662	beta-alpha-beta structure motif; other site
298386010663	NAD binding pocket [chemical binding]; other site
298386010664	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
298386010665	catalytic loop [active]
298386010666	iron binding site [ion binding]; other site
298386010667	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
298386010668	3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311
298386010669	transcription termination factor Rho; Provisional; Region: rho; PRK09376
298386010670	Rho termination factor, N-terminal domain; Region: Rho_N; smart00959
298386010671	Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459
298386010672	RNA binding site [nucleotide binding]; other site
298386010673	Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128
298386010674	multimer interface [polypeptide binding]; other site
298386010675	Walker A motif; other site
298386010676	ATP binding site [chemical binding]; other site
298386010677	Walker B motif; other site
298386010678	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
298386010679	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
298386010680	catalytic residues [active]
298386010681	ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837
298386010682	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
298386010683	ATP binding site [chemical binding]; other site
298386010684	Mg++ binding site [ion binding]; other site
298386010685	motif III; other site
298386010686	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
298386010687	nucleotide binding region [chemical binding]; other site
298386010688	ATP-binding site [chemical binding]; other site
298386010689	guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031
298386010690	Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541
298386010691	oligopeptidase A; Provisional; Region: PRK10911
298386010692	Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456
298386010693	active site
298386010694	Zn binding site [ion binding]; other site
298386010695	glutathione reductase; Validated; Region: PRK06116
298386010696	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
298386010697	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
298386010698	Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852
298386010699	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
298386010700	Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119
298386010701	catalytic loop [active]
298386010702	Nucleoside recognition; Region: Gate; pfam07670
298386010703	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
298386010704	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
298386010705	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386010706	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
298386010707	Transposase; Region: DEDD_Tnp_IS110; pfam01548
298386010708	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
298386010709	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386010710	Homeodomain-like domain; Region: HTH_23; pfam13384
298386010711	Winged helix-turn helix; Region: HTH_29; pfam13551
298386010712	Winged helix-turn helix; Region: HTH_33; pfam13592
298386010713	DDE superfamily endonuclease; Region: DDE_3; pfam13358
298386010714	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
298386010715	Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663
298386010716	Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645
298386010717	trimer interface [polypeptide binding]; other site
298386010718	putative metal binding site [ion binding]; other site
298386010719	Protein of unknown function (DUF1488); Region: DUF1488; pfam07369
298386010720	shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258
298386010721	Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501
298386010722	NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065
298386010723	shikimate binding site; other site
298386010724	NAD(P) binding site [chemical binding]; other site
298386010725	coproporphyrinogen III oxidase; Provisional; Region: PRK05330
298386010726	Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218
298386010727	Telomere recombination; Region: Sua5_yciO_yrdC; cl00305
298386010728	AIR carboxylase; Region: AIRC; pfam00731
298386010729	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
298386010730	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
298386010731	Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396
298386010732	hypothetical protein; Validated; Region: PRK03430
298386010733	hypothetical protein; Provisional; Region: PRK10736
298386010734	DNA protecting protein DprA; Region: dprA; TIGR00732
298386010735	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
298386010736	Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487
298386010737	active site
298386010738	catalytic residues [active]
298386010739	metal binding site [ion binding]; metal-binding site
298386010740	methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005
298386010741	Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646
298386010742	putative active site [active]
298386010743	substrate binding site [chemical binding]; other site
298386010744	putative cosubstrate binding site; other site
298386010745	catalytic site [active]
298386010746	C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704
298386010747	substrate binding site [chemical binding]; other site
298386010748	16S rRNA methyltransferase B; Provisional; Region: PRK10901
298386010749	RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cl00223
298386010750	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298386010751	S-adenosylmethionine binding site [chemical binding]; other site
298386010752	potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496
298386010753	TrkA-N domain; Region: TrkA_N; pfam02254
298386010754	TrkA-C domain; Region: TrkA_C; pfam02080
298386010755	TrkA-N domain; Region: TrkA_N; pfam02254
298386010756	TrkA-C domain; Region: TrkA_C; pfam02080
298386010757	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
298386010758	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
298386010759	hemolysin; Provisional; Region: PRK15087
298386010760	Sporulation control protein [General function prediction only]; Region: Spo0M; COG4326
298386010761	SpoOM protein; Region: Spo0M; pfam07070
298386010762	Transcriptional regulators [Transcription]; Region: FadR; COG2186
298386010763	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298386010764	DNA-binding site [nucleotide binding]; DNA binding site
298386010765	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
298386010766	Protein of unknown function (DUF1040); Region: DUF1040; pfam06288
298386010767	cytochrome c oxidase accessory protein FixG; Region: ccoG_rdxA_fixG; TIGR02745
298386010768	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
298386010769	Ubp3 associated protein Bre5; Region: Bre5; pfam11614
298386010770	serine/threonine protein kinase; Provisional; Region: PRK11768
298386010771	Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334
298386010772	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
298386010773	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
298386010774	catalytic residues [active]
298386010775	hinge region; other site
298386010776	alpha helical domain; other site
298386010777	Uncharacterized conserved protein [Function unknown]; Region: COG1683
298386010778	Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606
298386010779	Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541
298386010780	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298386010781	Walker A motif; other site
298386010782	ATP binding site [chemical binding]; other site
298386010783	Walker B motif; other site
298386010784	arginine finger; other site
298386010785	Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335
298386010786	acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978
298386010787	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
298386010788	PYR/PP interface [polypeptide binding]; other site
298386010789	dimer interface [polypeptide binding]; other site
298386010790	TPP binding site [chemical binding]; other site
298386010791	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
298386010792	Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015
298386010793	TPP-binding site [chemical binding]; other site
298386010794	dimer interface [polypeptide binding]; other site
298386010795	Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115
298386010796	BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids  leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557
298386010797	homodimer interface [polypeptide binding]; other site
298386010798	substrate-cofactor binding pocket; other site
298386010799	catalytic residue [active]
298386010800	dihydroxy-acid dehydratase; Provisional; Region: PRK12448
298386010801	threonine dehydratase; Reviewed; Region: PRK09224
298386010802	Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562
298386010803	tetramer interface [polypeptide binding]; other site
298386010804	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298386010805	catalytic residue [active]
298386010806	First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906
298386010807	putative Ile/Val binding site [chemical binding]; other site
298386010808	Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907
298386010809	putative Ile/Val binding site [chemical binding]; other site
298386010810	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
298386010811	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298386010812	non-specific DNA binding site [nucleotide binding]; other site
298386010813	salt bridge; other site
298386010814	sequence-specific DNA binding site [nucleotide binding]; other site
298386010815	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298386010816	sequence-specific DNA binding site [nucleotide binding]; other site
298386010817	salt bridge; other site
298386010818	glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331
298386010819	Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans).  The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714
298386010820	glutaminase active site [active]
298386010821	SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008
298386010822	dimer interface [polypeptide binding]; other site
298386010823	active site
298386010824	SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009
298386010825	dimer interface [polypeptide binding]; other site
298386010826	active site
298386010827	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
298386010828	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
298386010829	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
298386010830	bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451
298386010831	N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540
298386010832	Substrate binding site; other site
298386010833	Mg++ binding site; other site
298386010834	N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353
298386010835	active site
298386010836	substrate binding site [chemical binding]; other site
298386010837	CoA binding site [chemical binding]; other site
298386010838	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
298386010839	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
298386010840	gamma subunit interface [polypeptide binding]; other site
298386010841	epsilon subunit interface [polypeptide binding]; other site
298386010842	LBP interface [polypeptide binding]; other site
298386010843	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
298386010844	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
298386010845	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
298386010846	alpha subunit interaction interface [polypeptide binding]; other site
298386010847	Walker A motif; other site
298386010848	ATP binding site [chemical binding]; other site
298386010849	Walker B motif; other site
298386010850	inhibitor binding site; inhibition site
298386010851	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
298386010852	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
298386010853	core domain interface [polypeptide binding]; other site
298386010854	delta subunit interface [polypeptide binding]; other site
298386010855	epsilon subunit interface [polypeptide binding]; other site
298386010856	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
298386010857	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
298386010858	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
298386010859	beta subunit interaction interface [polypeptide binding]; other site
298386010860	Walker A motif; other site
298386010861	ATP binding site [chemical binding]; other site
298386010862	Walker B motif; other site
298386010863	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
298386010864	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
298386010865	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
298386010866	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
298386010867	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
298386010868	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
298386010869	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
298386010870	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
298386010871	F0F1 ATP synthase subunit I; Validated; Region: PRK05760
298386010872	ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180
298386010873	ParB-like nuclease domain; Region: ParBc; pfam02195
298386010874	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
298386010875	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
298386010876	P-loop; other site
298386010877	Magnesium ion binding site [ion binding]; other site
298386010878	rRNA small subunit methyltransferase G; Region: GidB; pfam02527
298386010879	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298386010880	S-adenosylmethionine binding site [chemical binding]; other site
298386010881	tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192
298386010882	NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206
298386010883	GidA associated domain 3; Region: GIDA_assoc_3; pfam13932
298386010884	Protein of unknown function (DUF3346); Region: DUF3346; pfam11826
298386010885	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
298386010886	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
298386010887	active site
298386010888	nucleophile elbow; other site
298386010889	Surface antigen; Region: Bac_surface_Ag; pfam01103
298386010890	tetrathionate reductase subunit A; Provisional; Region: PRK14991
298386010891	Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a  large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928
298386010892	molybdopterin cofactor binding site; other site
298386010893	The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758
298386010894	putative molybdopterin cofactor binding site [chemical binding]; other site
298386010895	This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780
298386010896	putative molybdopterin cofactor binding site; other site
298386010897	tetrathionate reductase subunit C; Provisional; Region: PRK14992
298386010898	Transposase IS200 like; Region: Y1_Tnp; pfam01797
298386010899	4Fe-4S dicluster domain; Region: Fer4_11; pfam13247
298386010900	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
298386010901	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298386010902	dimer interface [polypeptide binding]; other site
298386010903	phosphorylation site [posttranslational modification]
298386010904	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386010905	ATP binding site [chemical binding]; other site
298386010906	Mg2+ binding site [ion binding]; other site
298386010907	G-X-G motif; other site
298386010908	Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566
298386010909	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386010910	active site
298386010911	phosphorylation site [posttranslational modification]
298386010912	intermolecular recognition site; other site
298386010913	dimerization interface [polypeptide binding]; other site
298386010914	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298386010915	DNA binding residues [nucleotide binding]
298386010916	dimerization interface [polypeptide binding]; other site
298386010917	maltose O-acetyltransferase; Provisional; Region: PRK10092
298386010918	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
298386010919	active site
298386010920	substrate binding site [chemical binding]; other site
298386010921	trimer interface [polypeptide binding]; other site
298386010922	CoA binding site [chemical binding]; other site
298386010923	Helix-turn-helix domain; Region: HTH_18; pfam12833
298386010924	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298386010925	DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133
298386010926	active site
298386010927	catalytic site [active]
298386010928	substrate binding site [chemical binding]; other site
298386010929	EamA-like transporter family; Region: EamA; pfam00892
298386010930	Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950
298386010931	EamA-like transporter family; Region: EamA; pfam00892
298386010932	DDE domain; Region: DDE_Tnp_IS240; pfam13610
298386010933	Integrase core domain; Region: rve; pfam00665
298386010934	Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236
298386010935	Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318
298386010936	Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931
298386010937	acyl-activating enzyme (AAE) consensus motif; other site
298386010938	active site
298386010939	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
298386010940	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
298386010941	putative acyl-acceptor binding pocket; other site
298386010942	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
298386010943	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386010944	Integrase core domain; Region: rve; pfam00665
298386010945	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
298386010946	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
298386010947	N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653
298386010948	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298386010949	active site
298386010950	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298386010951	alpha-galactosidase; Provisional; Region: PRK15076
298386010952	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
298386010953	NAD binding site [chemical binding]; other site
298386010954	sugar binding site [chemical binding]; other site
298386010955	divalent metal binding site [ion binding]; other site
298386010956	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
298386010957	dimer interface [polypeptide binding]; other site
298386010958	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
298386010959	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
298386010960	TM-ABC transporter signature motif; other site
298386010961	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
298386010962	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298386010963	Walker A/P-loop; other site
298386010964	ATP binding site [chemical binding]; other site
298386010965	Q-loop/lid; other site
298386010966	ABC transporter signature motif; other site
298386010967	Walker B; other site
298386010968	D-loop; other site
298386010969	H-loop/switch region; other site
298386010970	Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_4; cd06312
298386010971	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
298386010972	putative ligand binding site [chemical binding]; other site
298386010973	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386010974	DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766
298386010975	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386010976	active site
298386010977	phosphorylation site [posttranslational modification]
298386010978	intermolecular recognition site; other site
298386010979	dimerization interface [polypeptide binding]; other site
298386010980	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298386010981	DNA binding site [nucleotide binding]
298386010982	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
298386010983	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
298386010984	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
298386010985	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298386010986	dimerization interface [polypeptide binding]; other site
298386010987	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298386010988	dimerization interface [polypeptide binding]; other site
298386010989	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298386010990	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298386010991	dimer interface [polypeptide binding]; other site
298386010992	phosphorylation site [posttranslational modification]
298386010993	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386010994	ATP binding site [chemical binding]; other site
298386010995	Mg2+ binding site [ion binding]; other site
298386010996	G-X-G motif; other site
298386010997	Response regulator receiver domain; Region: Response_reg; pfam00072
298386010998	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386010999	active site
298386011000	phosphorylation site [posttranslational modification]
298386011001	intermolecular recognition site; other site
298386011002	dimerization interface [polypeptide binding]; other site
298386011003	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
298386011004	putative binding surface; other site
298386011005	active site
298386011006	Predicted transcriptional regulators [Transcription]; Region: COG1695
298386011007	Transcriptional regulator PadR-like family; Region: PadR; pfam03551
298386011008	Virulence activator alpha C-term; Region: Vir_act_alpha_C; pfam10400
298386011009	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
298386011010	Cache is an extracellular domain that is predicted to have a role in small-molecule recognition in a wide range of proteins; Region: Cache_2; smart01049
298386011011	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
298386011012	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298386011013	dimerization interface [polypeptide binding]; other site
298386011014	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
298386011015	dimer interface [polypeptide binding]; other site
298386011016	putative CheW interface [polypeptide binding]; other site
298386011017	Predicted ornithine cyclodeaminase, mu-crystallin homolog [Amino acid transport and metabolism]; Region: COG2423
298386011018	ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400
298386011019	transaminase; Validated; Region: PRK07324
298386011020	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
298386011021	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298386011022	homodimer interface [polypeptide binding]; other site
298386011023	catalytic residue [active]
298386011024	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964
298386011025	YheO-like PAS domain; Region: PAS_6; pfam08348
298386011026	HTH domain; Region: HTH_22; pfam13309
298386011027	beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525
298386011028	Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837
298386011029	Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703
298386011030	Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836
298386011031	Beta galactosidase small chain; Region: Bgal_small_N; pfam02929
298386011032	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
298386011033	DNA-binding site [nucleotide binding]; DNA binding site
298386011034	RNA-binding motif; other site
298386011035	Radical SAM superfamily; Region: Radical_SAM; pfam04055
298386011036	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
298386011037	FeS/SAM binding site; other site
298386011038	Uncharacterized conserved protein [Function unknown]; Region: COG3791
298386011039	Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754
298386011040	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298386011041	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298386011042	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
298386011043	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
298386011044	Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706
298386011045	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298386011046	Coenzyme A binding pocket [chemical binding]; other site
298386011047	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386011048	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386011049	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
298386011050	dimerization interface [polypeptide binding]; other site
298386011051	aspartate ammonia-lyase; Provisional; Region: PRK13353
298386011052	Lyase class I_like superfamily: contains the lyase class I family, histidine ammonia-lyase and phenylalanine ammonia-lyase, which catalyze similar beta-elimination reactions; Region: Lyase_I_like; cl00013
298386011053	tetramer interface [polypeptide binding]; other site
298386011054	Uncharacterized protein involved in propionate catabolism [General function prediction only]; Region: PrpD; COG2079
298386011055	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
298386011056	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
298386011057	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
298386011058	hypothetical protein; Provisional; Region: PRK11653
298386011059	Predicted membrane protein [Function unknown]; Region: COG3766
298386011060	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
298386011061	Domain of Unknown Function (DUF350); Region: DUF350; pfam03994
298386011062	Protein of unknown function (DUF2491); Region: DUF2491; pfam10679
298386011063	Ion channel; Region: Ion_trans_2; pfam07885
298386011064	TrkA-N domain; Region: TrkA_N; pfam02254
298386011065	PspA/IM30 family; Region: PspA_IM30; pfam04012
298386011066	Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551
298386011067	transketolase; Reviewed; Region: PRK12753
298386011068	Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012
298386011069	TPP-binding site [chemical binding]; other site
298386011070	dimer interface [polypeptide binding]; other site
298386011071	Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033
298386011072	PYR/PP interface [polypeptide binding]; other site
298386011073	dimer interface [polypeptide binding]; other site
298386011074	TPP binding site [chemical binding]; other site
298386011075	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
298386011076	transaldolase-like protein; Provisional; Region: PTZ00411
298386011077	Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957
298386011078	active site
298386011079	dimer interface [polypeptide binding]; other site
298386011080	catalytic residue [active]
298386011081	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298386011082	HAMP domain; Region: HAMP; pfam00672
298386011083	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298386011084	dimer interface [polypeptide binding]; other site
298386011085	phosphorylation site [posttranslational modification]
298386011086	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386011087	ATP binding site [chemical binding]; other site
298386011088	Mg2+ binding site [ion binding]; other site
298386011089	G-X-G motif; other site
298386011090	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
298386011091	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386011092	active site
298386011093	phosphorylation site [posttranslational modification]
298386011094	intermolecular recognition site; other site
298386011095	dimerization interface [polypeptide binding]; other site
298386011096	Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088
298386011097	putative binding surface; other site
298386011098	active site
298386011099	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
298386011100	purine nucleoside phosphorylase; Provisional; Region: PRK13374
298386011101	Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820
298386011102	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298386011103	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
298386011104	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
298386011105	FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790
298386011106	Sel1 repeat; Region: Sel1; pfam08238
298386011107	6-phosphogluconate phosphatase; Provisional; Region: PRK10563
298386011108	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
298386011109	active site
298386011110	motif I; other site
298386011111	motif II; other site
298386011112	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
298386011113	Xenobiotic acyltransferase (XAT): The XAT class of hexapeptide acyltransferases is composed of a large number of microbial enzymes that catalyze the CoA-dependent acetylation of a variety of hydroxyl-bearing acceptors such as chloramphenicol and...; Region: LbH_XAT; cd03349
298386011114	trimer interface [polypeptide binding]; other site
298386011115	active site
298386011116	substrate binding site [chemical binding]; other site
298386011117	CoA binding site [chemical binding]; other site
298386011118	penicillin-binding protein 2; Region: pbp2_mrdA; TIGR03423
298386011119	Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717
298386011120	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905
298386011121	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
298386011122	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298386011123	NAD(P) binding site [chemical binding]; other site
298386011124	active site
298386011125	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386011126	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386011127	LysR substrate binding domain; Region: LysR_substrate; pfam03466
298386011128	dimerization interface [polypeptide binding]; other site
298386011129	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
298386011130	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
298386011131	acetate kinase; Reviewed; Region: PRK12440
298386011132	propionate/acetate kinase; Provisional; Region: PRK12379
298386011133	Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509
298386011134	esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840
298386011135	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
298386011136	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
298386011137	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
298386011138	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298386011139	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
298386011140	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298386011141	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
298386011142	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769
298386011143	molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509
298386011144	molybdopterin cofactor binding site [chemical binding]; other site
298386011145	substrate binding site [chemical binding]; other site
298386011146	The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR),  trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793
298386011147	molybdopterin cofactor binding site; other site
298386011148	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
298386011149	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298386011150	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
298386011151	C4-dicarboxylate transporters of the Tellurite-resistance/Dicarboxylate Transporter (TDT) family; Region: TDT_C4-dicarb_trans; cd09325
298386011152	gating phenylalanine in ion channel; other site
298386011153	DDE superfamily endonuclease; Region: DDE_3; pfam13358
298386011154	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
298386011155	Homeodomain-like domain; Region: HTH_23; pfam13384
298386011156	Winged helix-turn helix; Region: HTH_29; pfam13551
298386011157	Winged helix-turn helix; Region: HTH_33; pfam13592
298386011158	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
298386011159	Ligand Binding Site [chemical binding]; other site
298386011160	Predicted transcriptional regulator [Transcription]; Region: COG2932
298386011161	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
298386011162	Catalytic site [active]
298386011163	Mor transcription activator family; Region: Mor; cl02360
298386011164	Domain of unknown function (DUF4285); Region: DUF4285; pfam14113
298386011165	Predicted P-loop ATPase [General function prediction only]; Region: COG4928
298386011166	KAP family P-loop domain; Region: KAP_NTPase; pfam07693
298386011167	Transposase IS200 like; Region: Y1_Tnp; pfam01797
298386011168	Nitrate and nitrite sensing; Region: NIT; pfam08376
298386011169	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
298386011170	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
298386011171	dimer interface [polypeptide binding]; other site
298386011172	putative CheW interface [polypeptide binding]; other site
298386011173	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386011174	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
298386011175	dimerization interface [polypeptide binding]; other site
298386011176	Acyl-coenzyme A:6-aminopenicillanic acid acyl-transferase; Region: AAT; pfam03417
298386011177	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
298386011178	3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116
298386011179	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
298386011180	dimer interface [polypeptide binding]; other site
298386011181	active site
298386011182	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
298386011183	3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831
298386011184	NAD(P) binding site [chemical binding]; other site
298386011185	homotetramer interface [polypeptide binding]; other site
298386011186	homodimer interface [polypeptide binding]; other site
298386011187	active site
298386011188	Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289
298386011189	putative active site 1 [active]
298386011190	3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185
298386011191	Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834
298386011192	dimer interface [polypeptide binding]; other site
298386011193	active site
298386011194	Protein of unknown function (DUF3261); Region: DUF3261; pfam11659
298386011195	Predicted exporter [General function prediction only]; Region: COG4258
298386011196	Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548
298386011197	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
298386011198	active site
298386011199	Phenylalanine ammonia-lyase (PAL) and histidine ammonia-lyase (HAL); Region: PAL-HAL; cd00332
298386011200	active sites [active]
298386011201	tetramer interface [polypeptide binding]; other site
298386011202	Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463
298386011203	DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179
298386011204	Ligand binding site; other site
298386011205	Putative Catalytic site; other site
298386011206	DXD motif; other site
298386011207	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
298386011208	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
298386011209	putative acyl-acceptor binding pocket; other site
298386011210	The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509
298386011211	active site 2 [active]
298386011212	active site 1 [active]
298386011213	Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365
298386011214	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298386011215	acyl-activating enzyme (AAE) consensus motif; other site
298386011216	AMP binding site [chemical binding]; other site
298386011217	active site
298386011218	CoA binding site [chemical binding]; other site
298386011219	Predicted membrane protein [Function unknown]; Region: COG4648
298386011220	acyl carrier protein; Provisional; Region: PRK05350
298386011221	Phosphopantetheine attachment site; Region: PP-binding; cl09936
298386011222	1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204
298386011223	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
298386011224	putative acyl-acceptor binding pocket; other site
298386011225	Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723
298386011226	O-methyltransferase; Region: Methyltransf_2; pfam00891
298386011227	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
298386011228	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
298386011229	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
298386011230	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
298386011231	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
298386011232	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
298386011233	Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905
298386011234	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
298386011235	EamA-like transporter family; Region: EamA; pfam00892
298386011236	EamA-like transporter family; Region: EamA; pfam00892
298386011237	F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356
298386011238	F0F1 ATP synthase subunit A; Validated; Region: PRK05815
298386011239	F0F1 ATP synthase subunit C; Validated; Region: PRK06876
298386011240	F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711
298386011241	F0F1 ATP synthase subunit B; Validated; Region: PRK05759
298386011242	F0F1 ATP synthase subunit delta; Validated; Region: PRK05758
298386011243	ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213
298386011244	F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281
298386011245	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
298386011246	F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132
298386011247	beta subunit interaction interface [polypeptide binding]; other site
298386011248	Walker A motif; other site
298386011249	ATP binding site [chemical binding]; other site
298386011250	Walker B motif; other site
298386011251	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
298386011252	mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151
298386011253	core domain interface [polypeptide binding]; other site
298386011254	delta subunit interface [polypeptide binding]; other site
298386011255	epsilon subunit interface [polypeptide binding]; other site
298386011256	F0F1 ATP synthase subunit beta; Validated; Region: PRK09280
298386011257	ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874
298386011258	F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133
298386011259	alpha subunit interaction interface [polypeptide binding]; other site
298386011260	Walker A motif; other site
298386011261	ATP binding site [chemical binding]; other site
298386011262	Walker B motif; other site
298386011263	inhibitor binding site; inhibition site
298386011264	ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306
298386011265	F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571
298386011266	mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152
298386011267	gamma subunit interface [polypeptide binding]; other site
298386011268	epsilon subunit interface [polypeptide binding]; other site
298386011269	LBP interface [polypeptide binding]; other site
298386011270	Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629
298386011271	Sulfatase; Region: Sulfatase; cl17466
298386011272	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
298386011273	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
298386011274	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
298386011275	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
298386011276	tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458
298386011277	putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815
298386011278	SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389
298386011279	AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010
298386011280	putative active site [active]
298386011281	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
298386011282	active site
298386011283	phosphorylation site [posttranslational modification]
298386011284	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715
298386011285	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
298386011286	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
298386011287	active pocket/dimerization site; other site
298386011288	active site
298386011289	phosphorylation site [posttranslational modification]
298386011290	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
298386011291	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
298386011292	active site
298386011293	dimer interface [polypeptide binding]; other site
298386011294	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
298386011295	2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK12481
298386011296	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
298386011297	NADP binding site [chemical binding]; other site
298386011298	homodimer interface [polypeptide binding]; other site
298386011299	active site
298386011300	Predicted unsaturated glucuronyl hydrolase involved in regulation of bacterial surface properties, and related proteins [General function prediction only]; Region: COG4225
298386011301	Domain of unknown function (DUF1083); Region: DUF1083; pfam06452
298386011302	putative ligand binding site [chemical binding]; other site
298386011303	Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688
298386011304	Lyase, N terminal; Region: Lyase_N; pfam09092
298386011305	Glycosaminoglycan (GAG) polysaccharide lyase family. This family consists of a group of secreted bacterial lyase enzymes capable of acting on glycosaminoglycans, such as hyaluronan and chondroitin, in the extracellular matrix of host tissues; Region: GAG_Lyase; cd01083
298386011306	substrate binding site [chemical binding]; other site
298386011307	catalytic residues [active]
298386011308	anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942
298386011309	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
298386011310	FeS/SAM binding site; other site
298386011311	radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085
298386011312	Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119
298386011313	Sulfatase; Region: Sulfatase; pfam00884
298386011314	Uncharacterized protein conserved in bacteria (DUF2264); Region: DUF2264; cl01752
298386011315	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
298386011316	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
298386011317	intersubunit interface [polypeptide binding]; other site
298386011318	active site
298386011319	zinc binding site [ion binding]; other site
298386011320	Na+ binding site [ion binding]; other site
298386011321	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
298386011322	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
298386011323	substrate binding site [chemical binding]; other site
298386011324	ATP binding site [chemical binding]; other site
298386011325	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
298386011326	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
298386011327	active site
298386011328	intersubunit interface [polypeptide binding]; other site
298386011329	catalytic residue [active]
298386011330	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
298386011331	DJ-1 family protein; Region: not_thiJ; TIGR01383
298386011332	conserved cys residue [active]
298386011333	Flagellin N-methylase; Region: FliB; pfam03692
298386011334	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
298386011335	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
298386011336	Coenzyme A binding pocket [chemical binding]; other site
298386011337	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
298386011338	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
298386011339	Transposase IS200 like; Region: Y1_Tnp; pfam01797
298386011340	Protein of unknown function (DUF1006); Region: DUF1006; pfam06224
298386011341	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214
298386011342	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298386011343	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298386011344	NAD(P) binding site [chemical binding]; other site
298386011345	active site
298386011346	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386011347	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386011348	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
298386011349	putative effector binding pocket; other site
298386011350	dimerization interface [polypeptide binding]; other site
298386011351	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
298386011352	Ligand Binding Site [chemical binding]; other site
298386011353	EamA-like transporter family; Region: EamA; pfam00892
298386011354	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298386011355	Coenzyme A binding pocket [chemical binding]; other site
298386011356	Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687
298386011357	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
298386011358	Uncharacterized proteins of the AP superfamily [General function prediction only]; Region: COG1524
298386011359	Sulfatase; Region: Sulfatase; cl17466
298386011360	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386011361	dimer interface [polypeptide binding]; other site
298386011362	conserved gate region; other site
298386011363	putative PBP binding loops; other site
298386011364	ABC-ATPase subunit interface; other site
298386011365	ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177
298386011366	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386011367	dimer interface [polypeptide binding]; other site
298386011368	conserved gate region; other site
298386011369	putative PBP binding loops; other site
298386011370	ABC-ATPase subunit interface; other site
298386011371	ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842
298386011372	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298386011373	Walker A/P-loop; other site
298386011374	ATP binding site [chemical binding]; other site
298386011375	Q-loop/lid; other site
298386011376	ABC transporter signature motif; other site
298386011377	Walker B; other site
298386011378	D-loop; other site
298386011379	H-loop/switch region; other site
298386011380	di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039
298386011381	YtkA-like; Region: YtkA; pfam13115
298386011382	Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412
298386011383	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
298386011384	hypothetical protein; Provisional; Region: PRK00967
298386011385	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386011386	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
298386011387	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
298386011388	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
298386011389	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
298386011390	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
298386011391	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386011392	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386011393	AAA domain; Region: AAA_28; pfam13521
298386011394	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
298386011395	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386011396	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
298386011397	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
298386011398	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
298386011399	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
298386011400	Tryptophan-rich protein (DUF2389); Region: DUF2389; pfam09493
298386011401	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298386011402	DNA-binding site [nucleotide binding]; DNA binding site
298386011403	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
298386011404	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
298386011405	ATP binding site [chemical binding]; other site
298386011406	Mg++ binding site [ion binding]; other site
298386011407	motif III; other site
298386011408	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
298386011409	nucleotide binding region [chemical binding]; other site
298386011410	ATP-binding site [chemical binding]; other site
298386011411	Predicted ferric reductase [Inorganic ion transport and metabolism]; Region: COG4097
298386011412	Ferric reductase like transmembrane component; Region: Ferric_reduct; pfam01794
298386011413	NAD(P) binding domain of  ferredoxin reductase-like proteins catalyze electron transfer between an NAD(P)-binding sub-domain of the alpha/beta class and a discrete (usually N-terminal) domain, which varies in orientation with respect to the NAD(P)...; Region: FNR_like_3; cd06198
298386011414	FAD binding pocket [chemical binding]; other site
298386011415	FAD binding motif [chemical binding]; other site
298386011416	phosphate binding motif [ion binding]; other site
298386011417	beta-alpha-beta structure motif; other site
298386011418	NAD binding pocket [chemical binding]; other site
298386011419	NmrA (a transcriptional regulator) and HSCARG (an NADPH sensor) like proteins, atypical (a) SDRs; Region: NmrA_like_SDR_a; cd05251
298386011420	NADP binding site [chemical binding]; other site
298386011421	active site
298386011422	regulatory binding site [polypeptide binding]; other site
298386011423	Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024
298386011424	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298386011425	substrate binding site [chemical binding]; other site
298386011426	oxyanion hole (OAH) forming residues; other site
298386011427	trimer interface [polypeptide binding]; other site
298386011428	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298386011429	dimerization interface [polypeptide binding]; other site
298386011430	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
298386011431	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
298386011432	dimer interface [polypeptide binding]; other site
298386011433	putative CheW interface [polypeptide binding]; other site
298386011434	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298386011435	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298386011436	TPR motif; other site
298386011437	binding surface
298386011438	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298386011439	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298386011440	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298386011441	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298386011442	metal binding site [ion binding]; metal-binding site
298386011443	active site
298386011444	I-site; other site
298386011445	hypothetical protein; Validated; Region: PRK09071
298386011446	Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885
298386011447	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298386011448	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386011449	ATP binding site [chemical binding]; other site
298386011450	Mg2+ binding site [ion binding]; other site
298386011451	G-X-G motif; other site
298386011452	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
298386011453	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386011454	active site
298386011455	phosphorylation site [posttranslational modification]
298386011456	intermolecular recognition site; other site
298386011457	dimerization interface [polypeptide binding]; other site
298386011458	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Ada; COG2169
298386011459	Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805
298386011460	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298386011461	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298386011462	AlkA N-terminal domain; Region: AlkA_N; pfam06029
298386011463	3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase [DNA replication, recombination, and repair]; Region: AlkA; COG0122
298386011464	endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056
298386011465	minor groove reading motif; other site
298386011466	helix-hairpin-helix signature motif; other site
298386011467	substrate binding pocket [chemical binding]; other site
298386011468	active site
298386011469	methylated-DNA--protein-cysteine methyltransferase; Provisional; Region: PRK00901
298386011470	The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445
298386011471	DNA binding site [nucleotide binding]
298386011472	active site
298386011473	ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776
298386011474	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
298386011475	ATP binding site [chemical binding]; other site
298386011476	Mg++ binding site [ion binding]; other site
298386011477	motif III; other site
298386011478	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
298386011479	nucleotide binding region [chemical binding]; other site
298386011480	ATP-binding site [chemical binding]; other site
298386011481	RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501
298386011482	putative RNA binding site [nucleotide binding]; other site
298386011483	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298386011484	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298386011485	DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388
298386011486	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298386011487	Walker A motif; other site
298386011488	ATP binding site [chemical binding]; other site
298386011489	Walker B motif; other site
298386011490	dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377
298386011491	dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364
298386011492	active site
298386011493	active pocket/dimerization site; other site
298386011494	phosphorylation site [posttranslational modification]
298386011495	Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367
298386011496	dimerization domain swap beta strand [polypeptide binding]; other site
298386011497	regulatory protein interface [polypeptide binding]; other site
298386011498	active site
298386011499	regulatory phosphorylation site [posttranslational modification]; other site
298386011500	Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080
298386011501	PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524
298386011502	PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391
298386011503	PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896
298386011504	dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005
298386011505	dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468
298386011506	Dak1 domain; Region: Dak1; pfam02733
298386011507	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
298386011508	PAS domain; Region: PAS_9; pfam13426
298386011509	putative active site [active]
298386011510	heme pocket [chemical binding]; other site
298386011511	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
298386011512	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
298386011513	dimer interface [polypeptide binding]; other site
298386011514	putative CheW interface [polypeptide binding]; other site
298386011515	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
298386011516	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR6; cd08272
298386011517	putative NAD(P) binding site [chemical binding]; other site
298386011518	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386011519	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386011520	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
298386011521	putative effector binding pocket; other site
298386011522	dimerization interface [polypeptide binding]; other site
298386011523	Helix-turn-helix domain; Region: HTH_18; pfam12833
298386011524	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298386011525	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386011526	Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409
298386011527	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
298386011528	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
298386011529	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
298386011530	catalytic residue [active]
298386011531	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
298386011532	substrate binding pocket [chemical binding]; other site
298386011533	Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062
298386011534	membrane-bound complex binding site; other site
298386011535	hinge residues; other site
298386011536	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298386011537	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298386011538	metal binding site [ion binding]; metal-binding site
298386011539	active site
298386011540	I-site; other site
298386011541	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
298386011542	alpha-glucosidase; Provisional; Region: PRK10137
298386011543	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386011544	alpha-glucosidase; Provisional; Region: PRK10137
298386011545	Transcriptional regulators [Transcription]; Region: GntR; COG1802
298386011546	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298386011547	DNA-binding site [nucleotide binding]; DNA binding site
298386011548	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
298386011549	Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714
298386011550	Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377
298386011551	tetramer interface [polypeptide binding]; other site
298386011552	active site
298386011553	Mg2+/Mn2+ binding site [ion binding]; other site
298386011554	Citrate synthase [Energy production and conversion]; Region: GltA; COG0372
298386011555	Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS) catalyzes...; Region: Ec2MCS_like; cd06108
298386011556	dimer interface [polypeptide binding]; other site
298386011557	active site
298386011558	citrylCoA binding site [chemical binding]; other site
298386011559	oxalacetate/citrate binding site [chemical binding]; other site
298386011560	coenzyme A binding site [chemical binding]; other site
298386011561	catalytic triad [active]
298386011562	2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425
298386011563	2-methylcitrate dehydratase; Region: prpD; TIGR02330
298386011564	propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524
298386011565	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298386011566	acyl-activating enzyme (AAE) consensus motif; other site
298386011567	AMP binding site [chemical binding]; other site
298386011568	active site
298386011569	CoA binding site [chemical binding]; other site
298386011570	SnoaL-like polyketide cyclase; Region: SnoaL; pfam07366
298386011571	L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681
298386011572	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
298386011573	homotrimer interaction site [polypeptide binding]; other site
298386011574	putative active site [active]
298386011575	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
298386011576	threonine/serine transporter TdcC; Provisional; Region: PRK13629; cl17672
298386011577	Fatty acyltransferase-like subfamily of the SGNH hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: fatty_acyltransferase_like; cd01846
298386011578	active site
298386011579	catalytic triad [active]
298386011580	oxyanion hole [active]
298386011581	Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820
298386011582	putative sugar binding sites [chemical binding]; other site
298386011583	Q-X-W motif; other site
298386011584	putative metal dependent hydrolase; Provisional; Region: PRK11598
298386011585	Na+/H+ antiporter subunit; Region: PhaG_MnhG_YufB; pfam03334
298386011586	Domain of unknown function (DUF1705); Region: DUF1705; pfam08019
298386011587	Sulfatase; Region: Sulfatase; pfam00884
298386011588	Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818
298386011589	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298386011590	metal binding site [ion binding]; metal-binding site
298386011591	active site
298386011592	I-site; other site
298386011593	PAS domain; Region: PAS_9; pfam13426
298386011594	Class III nucleotidyl cyclases; Region: Nucleotidyl_cyc_III; cl11967
298386011595	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
298386011596	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cl00159
298386011597	RNA polymerase sigma factor SigZ; Provisional; Region: PRK09637
298386011598	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298386011599	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
298386011600	DNA binding residues [nucleotide binding]
298386011601	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
298386011602	Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of  glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570
298386011603	C-terminal domain interface [polypeptide binding]; other site
298386011604	GSH binding site (G-site) [chemical binding]; other site
298386011605	dimer interface [polypeptide binding]; other site
298386011606	C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cd00299
298386011607	N-terminal domain interface [polypeptide binding]; other site
298386011608	dimer interface [polypeptide binding]; other site
298386011609	substrate binding pocket (H-site) [chemical binding]; other site
298386011610	ChaP, an enzyme involved in the biosynthesis of the antitumor agent chartreusin (cha); and similar proteins; Region: ChaP_like; cd08351
298386011611	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298386011612	metal binding site [ion binding]; metal-binding site
298386011613	Protein of unknown function, DUF393; Region: DUF393; pfam04134
298386011614	ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132
298386011615	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
298386011616	ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251
298386011617	Walker A/P-loop; other site
298386011618	ATP binding site [chemical binding]; other site
298386011619	Q-loop/lid; other site
298386011620	ABC transporter signature motif; other site
298386011621	Walker B; other site
298386011622	D-loop; other site
298386011623	H-loop/switch region; other site
298386011624	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298386011625	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
298386011626	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298386011627	DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371
298386011628	alpha-galactosidase; Provisional; Region: PRK15076
298386011629	Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297
298386011630	NAD binding site [chemical binding]; other site
298386011631	sugar binding site [chemical binding]; other site
298386011632	divalent metal binding site [ion binding]; other site
298386011633	putative tetramer (dimer of dimers) interface [polypeptide binding]; other site
298386011634	dimer interface [polypeptide binding]; other site
298386011635	melibiose:sodium symporter; Provisional; Region: PRK10429
298386011636	sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792
298386011637	Glycogen debranching enzyme [Carbohydrate transport and metabolism]; Region: GDB1; COG3408
298386011638	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298386011639	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298386011640	dimer interface [polypeptide binding]; other site
298386011641	phosphorylation site [posttranslational modification]
298386011642	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386011643	ATP binding site [chemical binding]; other site
298386011644	Mg2+ binding site [ion binding]; other site
298386011645	G-X-G motif; other site
298386011646	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
298386011647	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386011648	active site
298386011649	phosphorylation site [posttranslational modification]
298386011650	intermolecular recognition site; other site
298386011651	dimerization interface [polypeptide binding]; other site
298386011652	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298386011653	DNA binding site [nucleotide binding]
298386011654	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
298386011655	PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998
298386011656	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
298386011657	active site turn [active]
298386011658	phosphorylation site [posttranslational modification]
298386011659	Response regulator receiver domain; Region: Response_reg; pfam00072
298386011660	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386011661	active site
298386011662	phosphorylation site [posttranslational modification]
298386011663	intermolecular recognition site; other site
298386011664	dimerization interface [polypeptide binding]; other site
298386011665	Response regulator receiver domain; Region: Response_reg; pfam00072
298386011666	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386011667	active site
298386011668	phosphorylation site [posttranslational modification]
298386011669	intermolecular recognition site; other site
298386011670	dimerization interface [polypeptide binding]; other site
298386011671	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298386011672	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298386011673	metal binding site [ion binding]; metal-binding site
298386011674	active site
298386011675	I-site; other site
298386011676	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
298386011677	AsmA family; Region: AsmA; pfam05170
298386011678	AsmA-like C-terminal region; Region: AsmA_2; pfam13502
298386011679	N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441
298386011680	N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007
298386011681	putative active site [active]
298386011682	transcriptional repressor UlaR; Provisional; Region: PRK13509
298386011683	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
298386011684	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
298386011685	putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210
298386011686	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019
298386011687	AP (apurinic/apyrimidinic) site pocket; other site
298386011688	DNA interaction; other site
298386011689	Metal-binding active site; metal-binding site
298386011690	pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530
298386011691	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915
298386011692	motif II; other site
298386011693	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
298386011694	putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709
298386011695	Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220
298386011696	transcriptional repressor UlaR; Provisional; Region: PRK13509
298386011697	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
298386011698	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
298386011699	PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548
298386011700	Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037
298386011701	PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563
298386011702	active site
298386011703	P-loop; other site
298386011704	phosphorylation site [posttranslational modification]
298386011705	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
298386011706	active site
298386011707	phosphorylation site [posttranslational modification]
298386011708	L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193
298386011709	Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214
298386011710	intersubunit interface [polypeptide binding]; other site
298386011711	active site
298386011712	Zn2+ binding site [ion binding]; other site
298386011713	3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726
298386011714	active site
298386011715	dimer interface [polypeptide binding]; other site
298386011716	magnesium binding site [ion binding]; other site
298386011717	Glutamate decarboxylase and related PLP-dependent proteins [Amino acid transport and metabolism]; Region: GadB; COG0076
298386011718	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
298386011719	catalytic residue [active]
298386011720	Imidazolonepropionase and related amidohydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: HutI; COG1228
298386011721	Metallo-dependent hydrolases, subgroup A is part of the superfamily of metallo-dependent hydrolases, a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the...; Region: Met_dep_hydrolase_A; cd01299
298386011722	active site
298386011723	Predicted membrane protein [Function unknown]; Region: COG1288
298386011724	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
298386011725	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
298386011726	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815
298386011727	dimer interface [polypeptide binding]; other site
298386011728	active site
298386011729	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
298386011730	substrate binding site [chemical binding]; other site
298386011731	catalytic residue [active]
298386011732	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386011733	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386011734	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
298386011735	dimerization interface [polypeptide binding]; other site
298386011736	DOMON-like domain of an uncharacterized protein family; Region: DOMON_like_cytochrome; cd09625
298386011737	putative ligand binding site [chemical binding]; other site
298386011738	Catalase [Inorganic ion transport and metabolism]; Region: KatE; COG0753
298386011739	Clade 3 of the heme-binding enzyme catalase; Region: catalase_clade_3; cd08156
298386011740	tetramer interface [polypeptide binding]; other site
298386011741	heme binding pocket [chemical binding]; other site
298386011742	NADPH binding site [chemical binding]; other site
298386011743	Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861
298386011744	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
298386011745	Transposase; Region: DEDD_Tnp_IS110; pfam01548
298386011746	Winged helix-turn helix; Region: HTH_29; pfam13551
298386011747	Homeodomain-like domain; Region: HTH_32; pfam13565
298386011748	Integrase core domain; Region: rve; pfam00665
298386011749	Integrase core domain; Region: rve_3; pfam13683
298386011750	Transposase IS200 like; Region: Y1_Tnp; pfam01797
298386011751	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
298386011752	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298386011753	non-specific DNA binding site [nucleotide binding]; other site
298386011754	salt bridge; other site
298386011755	sequence-specific DNA binding site [nucleotide binding]; other site
298386011756	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
298386011757	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
298386011758	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
298386011759	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
298386011760	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386011761	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
298386011762	Protein of unknown function (DUF497); Region: DUF497; pfam04365
298386011763	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
298386011764	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
298386011765	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
298386011766	putative active site [active]
298386011767	putative NTP binding site [chemical binding]; other site
298386011768	putative nucleic acid binding site [nucleotide binding]; other site
298386011769	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
298386011770	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386011771	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
298386011772	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
298386011773	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
298386011774	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386011775	MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476
298386011776	Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217
298386011777	MOSC domain; Region: MOSC; pfam03473
298386011778	Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018
298386011779	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
298386011780	FAD binding pocket [chemical binding]; other site
298386011781	FAD binding motif [chemical binding]; other site
298386011782	phosphate binding motif [ion binding]; other site
298386011783	beta-alpha-beta structure motif; other site
298386011784	NAD binding pocket [chemical binding]; other site
298386011785	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
298386011786	catalytic loop [active]
298386011787	iron binding site [ion binding]; other site
298386011788	Glycosyl hydrolases family 8; Region: Glyco_hydro_8; cl01351
298386011789	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
298386011790	cellulose synthase catalytic subunit (UDP-forming); Region: CelA; TIGR03030
298386011791	CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421
298386011792	DXD motif; other site
298386011793	PilZ domain; Region: PilZ; pfam07238
298386011794	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
298386011795	putative catalytic site [active]
298386011796	putative metal binding site [ion binding]; other site
298386011797	putative phosphate binding site [ion binding]; other site
298386011798	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
298386011799	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
298386011800	NAD(P) binding site [chemical binding]; other site
298386011801	catalytic residues [active]
298386011802	Transcriptional activator of acetoin/glycerol metabolism [Secondary metabolites biosynthesis, transport, and catabolism / Transcription]; Region: AcoR; COG3284
298386011803	GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956
298386011804	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298386011805	Walker A motif; other site
298386011806	ATP binding site [chemical binding]; other site
298386011807	Walker B motif; other site
298386011808	arginine finger; other site
298386011809	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
298386011810	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
298386011811	N-acetylglucosamine-binding protein A; Reviewed; Region: PRK13211
298386011812	Chitin binding domain; Region: Chitin_bind_3; pfam03067
298386011813	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
298386011814	Small Multidrug Resistance protein; Region: Multi_Drug_Res; cl00910
298386011815	SlyX; Region: SlyX; cl01090
298386011816	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386011817	Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230
298386011818	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
298386011819	L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720
298386011820	Serine dehydratase beta chain; Region: SDH_beta; pfam03315
298386011821	Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313
298386011822	Alpha-glucosidases, family 31 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: COG1501
298386011823	CtsZ (cyclic tetrasaccharide-synthesizing enzyme Z) is a bacterial 6-alpha-glucosyltransferase, first identified in Arthrobacter globiformis, that produces cyclic tetrasaccharides together with a closely related enzyme CtsY.  CtsZ and CtsY both have a...; Region: GH31_transferase_CtsZ; cd06598
298386011824	putative active site [active]
298386011825	putative catalytic site [active]
298386011826	carbohydrate-binding modules from Bacteroides thetaiotaomicron SusE, SusF and similar proteins; Region: CBM_SusE-F_like; cl17376
298386011827	starch binding site [chemical binding]; other site
298386011828	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
298386011829	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298386011830	DNA-binding site [nucleotide binding]; DNA binding site
298386011831	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
298386011832	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298386011833	homodimer interface [polypeptide binding]; other site
298386011834	catalytic residue [active]
298386011835	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
298386011836	Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704
298386011837	anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412
298386011838	Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168
298386011839	potassium uptake protein, TrkH family; Region: 2a38; TIGR00933
298386011840	K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569
298386011841	TrkA-N domain; Region: TrkA_N; pfam02254
298386011842	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
298386011843	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386011844	active site
298386011845	phosphorylation site [posttranslational modification]
298386011846	intermolecular recognition site; other site
298386011847	dimerization interface [polypeptide binding]; other site
298386011848	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298386011849	DNA binding site [nucleotide binding]
298386011850	Domain of unknown function (DUF4118); Region: DUF4118; pfam13493
298386011851	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298386011852	dimer interface [polypeptide binding]; other site
298386011853	phosphorylation site [posttranslational modification]
298386011854	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386011855	ATP binding site [chemical binding]; other site
298386011856	Mg2+ binding site [ion binding]; other site
298386011857	G-X-G motif; other site
298386011858	DMSO reductase anchor subunit [General function prediction only]; Region: DmsC; COG3302
298386011859	anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166
298386011860	This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_DmsA-EC; cd02770
298386011861	putative [Fe4-S4] binding site [ion binding]; other site
298386011862	putative molybdopterin cofactor binding site [chemical binding]; other site
298386011863	The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a  predicted...; Region: MopB_CT_DmsA-EC; cd02794
298386011864	putative molybdopterin cofactor binding site; other site
298386011865	Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958
298386011866	ferredoxin-type protein; Provisional; Region: PRK10194
298386011867	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
298386011868	RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409
298386011869	Protein of unknown function (DUF3478); Region: DUF3478; pfam11964
298386011870	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
298386011871	Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1),  6-pyrovoyl...; Region: TFold; cl00263
298386011872	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
298386011873	EamA-like transporter family; Region: EamA; pfam00892
298386011874	Predicted dithiol-disulfide isomerase involved in polyketide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: FrnE; COG2761
298386011875	DsbA family, FrnE subfamily; FrnE is a DsbA-like protein containing a CXXC motif. It is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the aromatic antibiotics frenolicin and nanaomycins; Region: DsbA_FrnE; cd03024
298386011876	catalytic residues [active]
298386011877	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
298386011878	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298386011879	Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305
298386011880	Transglutaminase-like superfamily; Region: Transglut_core; pfam01841
298386011881	ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553
298386011882	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298386011883	Coenzyme A binding pocket [chemical binding]; other site
298386011884	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
298386011885	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386011886	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
298386011887	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386011888	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
298386011889	acetoacetyl-CoA reductase; Provisional; Region: PRK12824
298386011890	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298386011891	NAD(P) binding site [chemical binding]; other site
298386011892	active site
298386011893	phasin family protein; Region: phasin_3; TIGR02809
298386011894	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
298386011895	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
298386011896	Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837
298386011897	dimer interface [polypeptide binding]; other site
298386011898	6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363
298386011899	GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399
298386011900	active site
298386011901	trimer interface [polypeptide binding]; other site
298386011902	allosteric site; other site
298386011903	active site lid [active]
298386011904	hexamer (dimer of trimers) interface [polypeptide binding]; other site
298386011905	Transcriptional regulator [Transcription]; Region: MtlR; COG3722
298386011906	mannitol repressor protein; Provisional; Region: mtlR; PRK11001
298386011907	mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318
298386011908	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
298386011909	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
298386011910	PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083
298386011911	PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851
298386011912	PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567
298386011913	active site
298386011914	P-loop; other site
298386011915	phosphorylation site [posttranslational modification]
298386011916	PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211
298386011917	active site
298386011918	phosphorylation site [posttranslational modification]
298386011919	AAA domain; Region: AAA_32; pfam13654
298386011920	ATP-dependent protease Lon; Provisional; Region: PRK13765
298386011921	Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362
298386011922	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
298386011923	dimerization interface [polypeptide binding]; other site
298386011924	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
298386011925	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
298386011926	dimer interface [polypeptide binding]; other site
298386011927	putative CheW interface [polypeptide binding]; other site
298386011928	aromatic amino acid exporter; Provisional; Region: PRK11689
298386011929	CHASE3 domain; Region: CHASE3; pfam05227
298386011930	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
298386011931	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
298386011932	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
298386011933	dimer interface [polypeptide binding]; other site
298386011934	putative CheW interface [polypeptide binding]; other site
298386011935	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
298386011936	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
298386011937	Walker A/P-loop; other site
298386011938	ATP binding site [chemical binding]; other site
298386011939	Q-loop/lid; other site
298386011940	ABC transporter signature motif; other site
298386011941	Walker B; other site
298386011942	D-loop; other site
298386011943	H-loop/switch region; other site
298386011944	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
298386011945	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
298386011946	FtsX-like permease family; Region: FtsX; pfam02687
298386011947	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
298386011948	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
298386011949	FtsX-like permease family; Region: FtsX; pfam02687
298386011950	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
298386011951	SigmaW regulon antibacterial; Region: YdfA_immunity; cl12057
298386011952	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
298386011953	HlyD family secretion protein; Region: HlyD_3; pfam13437
298386011954	ferric transporter ATP-binding subunit; Provisional; Region: fbpC; PRK11432
298386011955	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298386011956	Walker A/P-loop; other site
298386011957	ATP binding site [chemical binding]; other site
298386011958	Q-loop/lid; other site
298386011959	ABC transporter signature motif; other site
298386011960	Walker B; other site
298386011961	D-loop; other site
298386011962	H-loop/switch region; other site
298386011963	TOBE domain; Region: TOBE_2; pfam08402
298386011964	ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178
298386011965	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386011966	dimer interface [polypeptide binding]; other site
298386011967	conserved gate region; other site
298386011968	putative PBP binding loops; other site
298386011969	ABC-ATPase subunit interface; other site
298386011970	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386011971	dimer interface [polypeptide binding]; other site
298386011972	conserved gate region; other site
298386011973	putative PBP binding loops; other site
298386011974	ABC-ATPase subunit interface; other site
298386011975	ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840
298386011976	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
298386011977	regulatory protein UhpC; Provisional; Region: PRK11663
298386011978	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298386011979	putative substrate translocation pore; other site
298386011980	Signal transduction histidine kinase, glucose-6-phosphate specific [Signal transduction mechanisms]; Region: UhpB; COG3851
298386011981	MASE1; Region: MASE1; pfam05231
298386011982	Histidine kinase; Region: HisKA_3; pfam07730
298386011983	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386011984	ATP binding site [chemical binding]; other site
298386011985	Mg2+ binding site [ion binding]; other site
298386011986	G-X-G motif; other site
298386011987	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298386011988	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386011989	active site
298386011990	phosphorylation site [posttranslational modification]
298386011991	intermolecular recognition site; other site
298386011992	dimerization interface [polypeptide binding]; other site
298386011993	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298386011994	DNA binding residues [nucleotide binding]
298386011995	dimerization interface [polypeptide binding]; other site
298386011996	Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004
298386011997	Cache domain; Region: Cache_1; pfam02743
298386011998	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298386011999	dimerization interface [polypeptide binding]; other site
298386012000	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
298386012001	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
298386012002	dimer interface [polypeptide binding]; other site
298386012003	putative CheW interface [polypeptide binding]; other site
298386012004	tryptophanase/L-cysteine desulfhydrase, PLP-dependent; Provisional; Region: tnaA; PRK13238
298386012005	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
298386012006	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
298386012007	catalytic residue [active]
298386012008	S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927
298386012009	RNA binding site [nucleotide binding]; other site
298386012010	GTPase RsgA; Reviewed; Region: PRK01889
298386012011	Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854
298386012012	GTPase/Zn-binding domain interface [polypeptide binding]; other site
298386012013	GTP/Mg2+ binding site [chemical binding]; other site
298386012014	G4 box; other site
298386012015	G5 box; other site
298386012016	G1 box; other site
298386012017	Switch I region; other site
298386012018	G2 box; other site
298386012019	G3 box; other site
298386012020	Switch II region; other site
298386012021	cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866
298386012022	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
298386012023	Cytochrome c; Region: Cytochrom_C; pfam00034
298386012024	Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843
298386012025	cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891
298386012026	Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_2; cd02865
298386012027	Subunit I/III interface [polypeptide binding]; other site
298386012028	Heme-copper oxidase subunit III subfamily. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane; Region: Heme_Cu_Oxidase_III_1; cd02864
298386012029	Subunit I/III interface [polypeptide binding]; other site
298386012030	Predicted small integral membrane protein [Function unknown]; Region: COG5605
298386012031	Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077
298386012032	Zn2+ binding site [ion binding]; other site
298386012033	Mg2+ binding site [ion binding]; other site
298386012034	DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335
298386012035	E3 ubiquitin-protein ligase SlrP; Provisional; Region: PRK15370
298386012036	malate dehydrogenase; Provisional; Region: PRK13529
298386012037	Malic enzyme, N-terminal domain; Region: malic; pfam00390
298386012038	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
298386012039	NAD(P) binding site [chemical binding]; other site
298386012040	tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282
298386012041	catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806
298386012042	active site
298386012043	HIGH motif; other site
298386012044	dimer interface [polypeptide binding]; other site
298386012045	KMSKS motif; other site
298386012046	Uncharacterized protein conserved in bacteria (DUF2076); Region: DUF2076; pfam09849
298386012047	hypothetical protein; Provisional; Region: PRK03757
298386012048	Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038
298386012049	Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560
298386012050	haloacid dehalogenase-like hydrolase; Region: HAD; cl17202
298386012051	fumarate hydratase; Reviewed; Region: fumC; PRK00485
298386012052	Class II fumarases; Region: Fumarase_classII; cd01362
298386012053	active site
298386012054	tetramer interface [polypeptide binding]; other site
298386012055	Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473
298386012056	M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like3; cd05668
298386012057	metal binding site [ion binding]; metal-binding site
298386012058	putative dimer interface [polypeptide binding]; other site
298386012059	Alpha amylase catalytic domain found in bacterial Alpha-amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac1_AmyA; cd11315
298386012060	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
298386012061	active site
298386012062	Ca binding site [ion binding]; other site
298386012063	catalytic site [active]
298386012064	glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00844
298386012065	ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508
298386012066	ligand binding site; other site
298386012067	oligomer interface; other site
298386012068	Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651
298386012069	dimer interface [polypeptide binding]; other site
298386012070	N-terminal domain interface [polypeptide binding]; other site
298386012071	sulfate 1 binding site; other site
298386012072	glycogen synthase; Provisional; Region: glgA; PRK00654
298386012073	This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791
298386012074	ADP-binding pocket [chemical binding]; other site
298386012075	homodimer interface [polypeptide binding]; other site
298386012076	Cache domain; Region: Cache_1; pfam02743
298386012077	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
298386012078	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298386012079	dimerization interface [polypeptide binding]; other site
298386012080	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
298386012081	dimer interface [polypeptide binding]; other site
298386012082	putative CheW interface [polypeptide binding]; other site
298386012083	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386012084	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386012085	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
298386012086	dimerization interface [polypeptide binding]; other site
298386012087	alpha,alpha-phosphotrehalase; Region: trehalose_treC; TIGR02403
298386012088	Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333
298386012089	Ca binding site [ion binding]; other site
298386012090	active site
298386012091	catalytic site [active]
298386012092	Tyrosine phosphatase family; Region: Y_phosphatase2; pfam03162
298386012093	glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100
298386012094	N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856
298386012095	Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326
298386012096	active site
298386012097	catalytic site [active]
298386012098	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
298386012099	Maltose operon periplasmic protein precursor (MalM); Region: MalM; pfam07148
298386012100	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
298386012101	Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_3; cd11349
298386012102	active site
298386012103	catalytic site [active]
298386012104	maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474
298386012105	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
298386012106	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
298386012107	Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202
298386012108	Phage derived protein Gp49-like (DUF891); Region: Gp49; pfam05973
298386012109	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298386012110	non-specific DNA binding site [nucleotide binding]; other site
298386012111	salt bridge; other site
298386012112	sequence-specific DNA binding site [nucleotide binding]; other site
298386012113	maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000
298386012114	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
298386012115	Walker A/P-loop; other site
298386012116	ATP binding site [chemical binding]; other site
298386012117	Q-loop/lid; other site
298386012118	ABC transporter signature motif; other site
298386012119	Walker B; other site
298386012120	D-loop; other site
298386012121	H-loop/switch region; other site
298386012122	TOBE domain; Region: TOBE_2; pfam08402
298386012123	maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474
298386012124	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
298386012125	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386012126	dimer interface [polypeptide binding]; other site
298386012127	conserved gate region; other site
298386012128	putative PBP binding loops; other site
298386012129	ABC-ATPase subunit interface; other site
298386012130	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
298386012131	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386012132	dimer interface [polypeptide binding]; other site
298386012133	conserved gate region; other site
298386012134	putative PBP binding loops; other site
298386012135	ABC-ATPase subunit interface; other site
298386012136	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298386012137	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298386012138	metal binding site [ion binding]; metal-binding site
298386012139	active site
298386012140	I-site; other site
298386012141	Protein of unknown function (DUF1415); Region: DUF1415; pfam07209
298386012142	exoribonuclease II; Provisional; Region: PRK05054
298386012143	Ribonuclease B OB domain; Region: OB_RNB; pfam08206
298386012144	RNB domain; Region: RNB; pfam00773
298386012145	S1 RNA binding domain; Region: S1; pfam00575
298386012146	DEAD-like helicases superfamily; Region: DEXDc; smart00487
298386012147	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
298386012148	ATP binding site [chemical binding]; other site
298386012149	Mg++ binding site [ion binding]; other site
298386012150	motif III; other site
298386012151	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
298386012152	nucleotide binding region [chemical binding]; other site
298386012153	ATP-binding site [chemical binding]; other site
298386012154	RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499
298386012155	putative RNA binding site [nucleotide binding]; other site
298386012156	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
298386012157	metal binding triad [ion binding]; metal-binding site
298386012158	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386012159	RelA- and SpoT-like ppGpp Synthetases and Hydrolases, catalytic domain; Region: Rel-Spo_like; cl11966
298386012160	metal binding triad [ion binding]; metal-binding site
298386012161	HopJ type III effector protein; Region: HopJ; pfam08888
298386012162	Protein of unknown function (DUF2750); Region: DUF2750; pfam11042
298386012163	Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; pfam13557
298386012164	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423
298386012165	putative active site [active]
298386012166	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
298386012167	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298386012168	Walker A motif; other site
298386012169	ATP binding site [chemical binding]; other site
298386012170	Walker B motif; other site
298386012171	arginine finger; other site
298386012172	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
298386012173	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
298386012174	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
298386012175	substrate binding pocket [chemical binding]; other site
298386012176	membrane-bound complex binding site; other site
298386012177	hinge residues; other site
298386012178	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
298386012179	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
298386012180	N-acetyl-D-glucosamine binding site [chemical binding]; other site
298386012181	catalytic residue [active]
298386012182	anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263
298386012183	ATP cone domain; Region: ATP-cone; pfam03477
298386012184	Class III ribonucleotide reductase; Region: RNR_III; cd01675
298386012185	effector binding site; other site
298386012186	active site
298386012187	Zn binding site [ion binding]; other site
298386012188	glycine loop; other site
298386012189	4Fe-4S single cluster domain; Region: Fer4_12; pfam13353
298386012190	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
298386012191	FeS/SAM binding site; other site
298386012192	Protein of unknown function (DUF2960); Region: DUF2960; pfam11173
298386012193	Ceramidase; Region: Ceramidase; pfam05875
298386012194	superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280
298386012195	heme-binding site [chemical binding]; other site
298386012196	Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814
298386012197	serine transporter; Region: stp; TIGR00814
298386012198	RibD C-terminal domain; Region: RibD_C; cl17279
298386012199	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298386012200	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298386012201	Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909
298386012202	DsbA family, FrnE-like subfamily; composed of uncharacterized proteins containing a CXXC motif with similarity to DsbA and FrnE. FrnE is presumed to be a thiol oxidoreductase involved in polyketide biosynthesis, specifically in the production of the...; Region: DsbA_FrnE_like; cd03025
298386012203	DSBA-like thioredoxin domain; Region: DSBA; pfam01323
298386012204	catalytic residues [active]
298386012205	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386012206	Protein of unknown function (DUF465); Region: DUF465; pfam04325
298386012207	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_19; cd07262
298386012208	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298386012209	cystathionine beta-lyase; Provisional; Region: PRK09028
298386012210	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
298386012211	homodimer interface [polypeptide binding]; other site
298386012212	substrate-cofactor binding pocket; other site
298386012213	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298386012214	catalytic residue [active]
298386012215	poly-beta-1,6 N-acetyl-D-glucosamine synthase; Region: PgaC_IcaA; TIGR03937
298386012216	CESA_like is  the cellulose synthase superfamily; Region: CESA_like; cd06423
298386012217	DXD motif; other site
298386012218	poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB; Region: deacetyl_PgaB; TIGR03938
298386012219	N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964
298386012220	putative active site [active]
298386012221	putative metal binding site [ion binding]; other site
298386012222	poly-beta-1,6 N-acetyl-D-glucosamine export porin PgaA; Region: PGA_TPR_OMP; TIGR03939
298386012223	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386012224	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386012225	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
298386012226	putative effector binding pocket; other site
298386012227	dimerization interface [polypeptide binding]; other site
298386012228	D-xylose transporter XylE; Provisional; Region: xylE; PRK10077
298386012229	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298386012230	putative substrate translocation pore; other site
298386012231	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298386012232	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
298386012233	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
298386012234	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
298386012235	PYR/PP interface [polypeptide binding]; other site
298386012236	dimer interface [polypeptide binding]; other site
298386012237	TPP binding site [chemical binding]; other site
298386012238	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
298386012239	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
298386012240	TPP-binding site; other site
298386012241	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
298386012242	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
298386012243	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
298386012244	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
298386012245	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
298386012246	substrate binding site [chemical binding]; other site
298386012247	ATP binding site [chemical binding]; other site
298386012248	KduI/IolB family; Region: KduI; pfam04962
298386012249	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
298386012250	intersubunit interface [polypeptide binding]; other site
298386012251	active site
298386012252	zinc binding site [ion binding]; other site
298386012253	Na+ binding site [ion binding]; other site
298386012254	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
298386012255	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
298386012256	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
298386012257	putative active site [active]
298386012258	Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261
298386012259	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
298386012260	Metal-binding active site; metal-binding site
298386012261	Uncharacterized enzyme involved in inositol metabolism [Carbohydrate transport and metabolism]; Region: IolB; COG3718
298386012262	Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673
298386012263	Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408
298386012264	Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894
298386012265	Transcriptional regulators [Transcription]; Region: RpiR; COG1737
298386012266	Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418
298386012267	RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013
298386012268	putative active site [active]
298386012269	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
298386012270	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
298386012271	TM-ABC transporter signature motif; other site
298386012272	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
298386012273	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
298386012274	Walker A/P-loop; other site
298386012275	ATP binding site [chemical binding]; other site
298386012276	Q-loop/lid; other site
298386012277	ABC transporter signature motif; other site
298386012278	Walker B; other site
298386012279	D-loop; other site
298386012280	H-loop/switch region; other site
298386012281	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
298386012282	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879
298386012283	Periplasmic binding proteins specific to rhizopines; Region: PBP1_rhizopine_binding_like; cd06301
298386012284	putative ligand binding site [chemical binding]; other site
298386012285	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
298386012286	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
298386012287	substrate binding site [chemical binding]; other site
298386012288	ATP binding site [chemical binding]; other site
298386012289	Uncharacterized protein conserved in bacteria (DUF2090); Region: DUF2090; pfam09863
298386012290	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3892
298386012291	Acetolactate synthase [Amino acid transport and metabolism]; Region: COG3962
298386012292	Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035
298386012293	PYR/PP interface [polypeptide binding]; other site
298386012294	dimer interface [polypeptide binding]; other site
298386012295	TPP binding site [chemical binding]; other site
298386012296	Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205
298386012297	Thiamine pyrophosphate (TPP) family, IolD subfamily, TPP-binding module; composed of proteins similar to Rhizobium leguminosarum bv. viciae IolD. IolD plays an important role in myo-inositol catabolism; Region: TPP_IolD; cd02003
298386012298	TPP-binding site; other site
298386012299	Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082
298386012300	AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060
298386012301	DNA interaction; other site
298386012302	Metal-binding active site; metal-binding site
298386012303	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
298386012304	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
298386012305	tetrameric interface [polypeptide binding]; other site
298386012306	NAD binding site [chemical binding]; other site
298386012307	catalytic residues [active]
298386012308	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
298386012309	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
298386012310	maltose O-acetyltransferase; Provisional; Region: PRK10092
298386012311	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
298386012312	active site
298386012313	substrate binding site [chemical binding]; other site
298386012314	trimer interface [polypeptide binding]; other site
298386012315	CoA binding site [chemical binding]; other site
298386012316	Methyltransferase domain; Region: Methyltransf_23; pfam13489
298386012317	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298386012318	S-adenosylmethionine binding site [chemical binding]; other site
298386012319	Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315
298386012320	PAS domain S-box; Region: sensory_box; TIGR00229
298386012321	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
298386012322	putative active site [active]
298386012323	heme pocket [chemical binding]; other site
298386012324	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298386012325	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298386012326	metal binding site [ion binding]; metal-binding site
298386012327	active site
298386012328	I-site; other site
298386012329	Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158
298386012330	active site residue [active]
298386012331	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298386012332	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
298386012333	efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998
298386012334	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
298386012335	HlyD family secretion protein; Region: HlyD_3; pfam13437
298386012336	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298386012337	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298386012338	AefR-like transcriptional repressor, C-terminal region; Region: TetR_C_7; pfam14246
298386012339	SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346
298386012340	DJ-1 family protein; Region: not_thiJ; TIGR01383
298386012341	Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135
298386012342	conserved cys residue [active]
298386012343	hypothetical protein; Provisional; Region: PRK02237
298386012344	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386012345	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
298386012346	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
298386012347	preprotein translocase subunit SecD; Reviewed; Region: secD; PRK12933
298386012348	SecD export protein N-terminal TM region; Region: SecD-TM1; cl08136
298386012349	protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916
298386012350	preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13021
298386012351	SecD/SecF GG Motif; Region: Sec_GG; pfam07549
298386012352	Protein export membrane protein; Region: SecD_SecF; pfam02355
298386012353	Protein of unknown function (DUF406); Region: DUF406; pfam04175
298386012354	TRAP transporter, 4TM/12TM fusion protein; Region: TRAP_fused; TIGR02123
298386012355	DctM-like transporters; Region: DctM; pfam06808
298386012356	TRAP-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: Imp; COG2358
298386012357	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
298386012358	Protein of unknown function (DUF3316); Region: DUF3316; pfam11777
298386012359	DEAD-like helicases superfamily; Region: DEXDc; smart00487
298386012360	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046
298386012361	ATP binding site [chemical binding]; other site
298386012362	putative Mg++ binding site [ion binding]; other site
298386012363	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
298386012364	nucleotide binding region [chemical binding]; other site
298386012365	ATP-binding site [chemical binding]; other site
298386012366	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
298386012367	PAS domain; Region: PAS_9; pfam13426
298386012368	putative active site [active]
298386012369	heme pocket [chemical binding]; other site
298386012370	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
298386012371	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
298386012372	dimer interface [polypeptide binding]; other site
298386012373	putative CheW interface [polypeptide binding]; other site
298386012374	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
298386012375	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298386012376	dimerization interface [polypeptide binding]; other site
298386012377	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
298386012378	dimer interface [polypeptide binding]; other site
298386012379	putative CheW interface [polypeptide binding]; other site
298386012380	Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022
298386012381	Bacterial long-chain fatty acid CoA synthetase (LC-FACS), including Marinobacter hydrocarbonoclasticus isoprenoid Coenzyme A synthetase; Region: LC_FACS_bac; cd05932
298386012382	acyl-activating enzyme (AAE) consensus motif; other site
298386012383	putative AMP binding site [chemical binding]; other site
298386012384	putative active site [active]
298386012385	putative CoA binding site [chemical binding]; other site
298386012386	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034
298386012387	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298386012388	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298386012389	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
298386012390	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
298386012391	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
298386012392	HlyD family secretion protein; Region: HlyD_3; pfam13437
298386012393	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
298386012394	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
298386012395	YhgE/Pip N-terminal domain; Region: pip_yhgE_Nterm; TIGR03061
298386012396	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
298386012397	ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698
298386012398	ABC-2 type transporter; Region: ABC2_membrane; cl17235
298386012399	Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139
298386012400	Uncharacterized protein conserved in bacteria [Function unknown]; Region: CreA; COG3045
298386012401	CreA protein; Region: CreA; pfam05981
298386012402	Domain of unknown function (DUF4163); Region: DUF4163; pfam13739
298386012403	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
298386012404	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298386012405	EamA-like transporter family; Region: EamA; pfam00892
298386012406	META domain; Region: META; pfam03724
298386012407	Protein of unknown function (DUF1289); Region: DUF1289; pfam06945
298386012408	Cysteine-rich CWC; Region: Cys_rich_CWC; pfam14375
298386012409	5-histidylcysteine sulfoxide synthase; Region: ovoA_Nterm; TIGR04344
298386012410	Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781
298386012411	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298386012412	S-adenosylmethionine binding site [chemical binding]; other site
298386012413	hydroxyglutarate oxidase; Provisional; Region: PRK11728
298386012414	Predicted dehydrogenase [General function prediction only]; Region: COG0579
298386012415	putative acetyltransferase YhhY; Provisional; Region: PRK10140
298386012416	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298386012417	Coenzyme A binding pocket [chemical binding]; other site
298386012418	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
298386012419	Pyrabactin resistance 1 (PYR1), PYR1-like (PYL), regulatory component of abscisic acid receptors (RCARs), and related proteins; Region: PYR_PYL_RCAR_like; cd07821
298386012420	putative hydrophobic ligand binding site [chemical binding]; other site
298386012421	protein interface [polypeptide binding]; other site
298386012422	gate; other site
298386012423	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386012424	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386012425	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
298386012426	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298386012427	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054
298386012428	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298386012429	dimer interface [polypeptide binding]; other site
298386012430	phosphorylation site [posttranslational modification]
298386012431	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386012432	ATP binding site [chemical binding]; other site
298386012433	Mg2+ binding site [ion binding]; other site
298386012434	G-X-G motif; other site
298386012435	Response regulator receiver domain; Region: Response_reg; pfam00072
298386012436	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386012437	active site
298386012438	phosphorylation site [posttranslational modification]
298386012439	intermolecular recognition site; other site
298386012440	dimerization interface [polypeptide binding]; other site
298386012441	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
298386012442	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386012443	active site
298386012444	phosphorylation site [posttranslational modification]
298386012445	intermolecular recognition site; other site
298386012446	dimerization interface [polypeptide binding]; other site
298386012447	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386012448	Glyco_18 domain; Region: Glyco_18; smart00636
298386012449	The GH18 (glycosyl hydrolase, family 18) type II chitinases hydrolyze chitin, an abundant polymer of beta-1,4-linked N-acetylglucosamine (GlcNAc) which is a major component of the cell wall of fungi and the exoskeleton of arthropods.  Chitinases have...; Region: GH18_chitinase-like; cl10447
298386012450	active site
298386012451	Uncharacterized protein contain chitin-binding domain type 3 [General function prediction only]; Region: COG3979
298386012452	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
298386012453	aromatic chitin/cellulose binding site residues [chemical binding]; other site
298386012454	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
298386012455	aromatic chitin/cellulose binding site residues [chemical binding]; other site
298386012456	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
298386012457	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
298386012458	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
298386012459	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
298386012460	ABC-ATPase subunit  interface; other site
298386012461	dimer interface [polypeptide binding]; other site
298386012462	putative PBP binding regions; other site
298386012463	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
298386012464	Metal binding protein PsaA.  These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species.  They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137
298386012465	metal binding site [ion binding]; metal-binding site
298386012466	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG2215
298386012467	Protein of unknown function (DUF1007); Region: DUF1007; pfam06226
298386012468	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
298386012469	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482
298386012470	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
298386012471	TrkA-N domain; Region: TrkA_N; pfam02254
298386012472	phage Epsilon15
298386012473	integrase; Provisional; Region: PRK09692
298386012474	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
298386012475	active site
298386012476	Int/Topo IB signature motif; other site
298386012477	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
298386012478	Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396
298386012479	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298386012480	non-specific DNA binding site [nucleotide binding]; other site
298386012481	salt bridge; other site
298386012482	sequence-specific DNA binding site [nucleotide binding]; other site
298386012483	RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487
298386012484	putative active site [active]
298386012485	putative NTP binding site [chemical binding]; other site
298386012486	putative nucleic acid binding site [nucleotide binding]; other site
298386012487	Helix-turn-helix domain; Region: HTH_17; cl17695
298386012488	RecT family; Region: RecT; pfam03837
298386012489	exonuclease VIII; Reviewed; Region: PRK09709
298386012490	exonuclease VIII; Reviewed; Region: PRK09709
298386012491	Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA; cl00391
298386012492	Terminase small subunit; Region: Terminase_2; pfam03592
298386012493	Bacteriophage head to tail connecting protein; Region: Head-tail_con; pfam12236
298386012494	hypothetical protein; Region: PHA00670
298386012495	putative protease; Region: PHA00666
298386012496	major capsid protein; Region: PHA00665
298386012497	hypothetical protein; Region: PHA00664
298386012498	hypothetical protein; Region: PHA00662
298386012499	hypothetical protein; Region: PHA00661
298386012500	hypothetical protein; Region: PHA00661
298386012501	hypothetical protein; Region: PHA00661
298386012502	hypothetical protein; Region: PHA01733
298386012503	crystallin beta/gamma motif-containing protein; Region: PHA00657
298386012504	hypothetical protein; Provisional; Region: PHA02515
298386012505	A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39_likeD; cd02421
298386012506	type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375
298386012507	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
298386012508	ATP-binding cassette domain of bacteriocin exporters, subfamily C; Region: ABCC_bacteriocin_exporters; cd03245
298386012509	Walker A/P-loop; other site
298386012510	ATP binding site [chemical binding]; other site
298386012511	Q-loop/lid; other site
298386012512	ABC transporter signature motif; other site
298386012513	Walker B; other site
298386012514	D-loop; other site
298386012515	H-loop/switch region; other site
298386012516	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298386012517	dimerization interface [polypeptide binding]; other site
298386012518	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298386012519	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298386012520	metal binding site [ion binding]; metal-binding site
298386012521	active site
298386012522	I-site; other site
298386012523	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
298386012524	Predicted transglutaminase-like cysteine proteinase [General    function prediction only]; Region: COG3672
298386012525	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
298386012526	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
298386012527	ligand binding site [chemical binding]; other site
298386012528	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
298386012529	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
298386012530	HlyD family secretion protein; Region: HlyD_3; pfam13437
298386012531	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
298386012532	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
298386012533	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
298386012534	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
298386012535	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
298386012536	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
298386012537	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
298386012538	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
298386012539	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
298386012540	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
298386012541	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
298386012542	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
298386012543	T1SS-143 repeat domain; Region: T1SS_rpt_143; TIGR03660
298386012544	type I secretion C-terminal target domain (VC_A0849 subclass); Region: T1SS_VCA0849; TIGR03661
298386012545	succinylarginine dihydrolase; Provisional; Region: PRK13281
298386012546	MarC family integral membrane protein; Region: MarC; pfam01914
298386012547	Homeodomain-like domain; Region: HTH_23; pfam13384
298386012548	Winged helix-turn helix; Region: HTH_29; pfam13551
298386012549	Winged helix-turn helix; Region: HTH_33; pfam13592
298386012550	DDE superfamily endonuclease; Region: DDE_3; pfam13358
298386012551	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
298386012552	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352
298386012553	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298386012554	putative metal binding site [ion binding]; other site
298386012555	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
298386012556	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
298386012557	FMN binding site [chemical binding]; other site
298386012558	active site
298386012559	substrate binding site [chemical binding]; other site
298386012560	catalytic residue [active]
298386012561	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386012562	transcriptional activator TtdR; Provisional; Region: PRK09801
298386012563	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
298386012564	putative effector binding pocket; other site
298386012565	dimerization interface [polypeptide binding]; other site
298386012566	Uncharacterized protein conserved in bacteria (DUF2058); Region: DUF2058; pfam09831
298386012567	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298386012568	binding surface
298386012569	TPR motif; other site
298386012570	TPR repeat; Region: TPR_11; pfam13414
298386012571	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298386012572	binding surface
298386012573	TPR motif; other site
298386012574	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298386012575	Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064
298386012576	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
298386012577	Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965
298386012578	Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482
298386012579	Type II/IV secretion system protein; Region: T2SE; pfam00437
298386012580	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
298386012581	ATP binding site [chemical binding]; other site
298386012582	Walker A motif; other site
298386012583	hexamer interface [polypeptide binding]; other site
298386012584	Walker B motif; other site
298386012585	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
298386012586	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386012587	active site
298386012588	phosphorylation site [posttranslational modification]
298386012589	intermolecular recognition site; other site
298386012590	dimerization interface [polypeptide binding]; other site
298386012591	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
298386012592	AAA domain; Region: AAA_31; pfam13614
298386012593	This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111
298386012594	TadE-like protein; Region: TadE; pfam07811
298386012595	Bacterial cellulose synthase subunit; Region: BcsB; cl15851
298386012596	Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961
298386012597	Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400
298386012598	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
298386012599	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386012600	Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964
298386012601	Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629
298386012602	BON domain; Region: BON; pfam04972
298386012603	Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745
298386012604	SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614
298386012605	Cdc6-related protein, AAA superfamily ATPase [DNA replication, recombination, and repair / Posttranslational modification, protein turnover, chaperones]; Region: CDC6; COG1474
298386012606	AAA domain; Region: AAA_17; pfam13207
298386012607	phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150
298386012608	This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799
298386012609	active site
298386012610	substrate binding site [chemical binding]; other site
298386012611	metal binding site [ion binding]; metal-binding site
298386012612	penicillin-binding protein 1B; Region: PBP_1b; TIGR02071
298386012613	Transglycosylase; Region: Transgly; pfam00912
298386012614	Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760
298386012615	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_27; cd04686
298386012616	nudix motif; other site
298386012617	Uncharacterized conserved protein [Function unknown]; Region: COG4104
298386012618	Domain of unknown function (DUF4123); Region: DUF4123; pfam13503
298386012619	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386012620	YceI-like domain; Region: YceI; pfam04264
298386012621	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
298386012622	Transposase; Region: DEDD_Tnp_IS110; pfam01548
298386012623	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
298386012624	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
298386012625	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; cl11421
298386012626	Protein of unknown function (DUF3820); Region: DUF3820; pfam12843
298386012627	hypothetical protein; Provisional; Region: yieM; PRK10997
298386012628	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057
298386012629	metal ion-dependent adhesion site (MIDAS); other site
298386012630	AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728
298386012631	Walker B motif; other site
298386012632	arginine finger; other site
298386012633	MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937
298386012634	Protein of unknown function (DUF3010); Region: DUF3010; pfam11215
298386012635	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298386012636	metal binding site [ion binding]; metal-binding site
298386012637	active site
298386012638	I-site; other site
298386012639	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
298386012640	Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451
298386012641	Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020
298386012642	succinic semialdehyde dehydrogenase; Region: PLN02278
298386012643	Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103
298386012644	tetramerization interface [polypeptide binding]; other site
298386012645	NAD(P) binding site [chemical binding]; other site
298386012646	catalytic residues [active]
298386012647	MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886
298386012648	MPT binding site; other site
298386012649	trimer interface [polypeptide binding]; other site
298386012650	The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cl01109
298386012651	putative amphipathic alpha helix; other site
298386012652	outer membrane protein A; Reviewed; Region: PRK10808
298386012653	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254
298386012654	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
298386012655	ligand binding site [chemical binding]; other site
298386012656	NapC/NirT cytochrome c family, N-terminal region; Region: Cytochrom_NNT; pfam03264
298386012657	cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554
298386012658	quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476
298386012659	4Fe-4S dicluster domain; Region: Fer4_9; pfam13187
298386012660	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
298386012661	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
298386012662	4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484
298386012663	quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477
298386012664	4Fe-4S binding domain; Region: Fer4_5; pfam12801
298386012665	MauM/NapG family ferredoxin-type protein; Region: mauM_napG; TIGR00397
298386012666	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
298386012667	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
298386012668	Anaerobic dehydrogenases, typically selenocysteine-containing [Energy production and conversion]; Region: BisC; COG0243
298386012669	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754
298386012670	[4Fe-4S] binding site [ion binding]; other site
298386012671	molybdopterin cofactor binding site; other site
298386012672	Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791
298386012673	molybdopterin cofactor binding site; other site
298386012674	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
298386012675	Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442
298386012676	Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331
298386012677	TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955
298386012678	catalytic residues [active]
298386012679	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
298386012680	HAMP domain; Region: HAMP; pfam00672
298386012681	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
298386012682	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
298386012683	dimer interface [polypeptide binding]; other site
298386012684	putative CheW interface [polypeptide binding]; other site
298386012685	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
298386012686	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386012687	DDE domain; Region: DDE_Tnp_IS240; pfam13610
298386012688	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386012689	active site
298386012690	phosphorylation site [posttranslational modification]
298386012691	intermolecular recognition site; other site
298386012692	dimerization interface [polypeptide binding]; other site
298386012693	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298386012694	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298386012695	TPR motif; other site
298386012696	binding surface
298386012697	Tetratricopeptide repeat; Region: TPR_16; pfam13432
298386012698	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
298386012699	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386012700	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3415
298386012701	Winged helix-turn helix; Region: HTH_33; pfam13592
298386012702	Peptidase family M48; Region: Peptidase_M48; pfam01435
298386012703	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
298386012704	CoenzymeA binding site [chemical binding]; other site
298386012705	subunit interaction site [polypeptide binding]; other site
298386012706	PHB binding site; other site
298386012707	Protein of unknown function (DUF3389); Region: DUF3389; pfam11869
298386012708	Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120
298386012709	active site
298386012710	Phosphotransferase enzyme family; Region: APH; pfam01636
298386012711	ATP binding site [chemical binding]; other site
298386012712	Fructosamine kinase; Region: Fructosamin_kin; cl17579
298386012713	Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682
298386012714	Protein of unknown function (DUF2797); Region: DUF2797; pfam10977
298386012715	Cytochrome C' Region: Cytochrom_C_2; pfam01322
298386012716	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
298386012717	Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934
298386012718	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386012719	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355
298386012720	DNA binding site [nucleotide binding]
298386012721	Protein of unknown function (DUF3069); Region: DUF3069; pfam11269
298386012722	Response regulator receiver domain; Region: Response_reg; pfam00072
298386012723	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386012724	active site
298386012725	phosphorylation site [posttranslational modification]
298386012726	intermolecular recognition site; other site
298386012727	dimerization interface [polypeptide binding]; other site
298386012728	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298386012729	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298386012730	metal binding site [ion binding]; metal-binding site
298386012731	active site
298386012732	I-site; other site
298386012733	hypothetical protein; Provisional; Region: PRK11239
298386012734	Protein of unknown function, DUF480; Region: DUF480; pfam04337
298386012735	The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456
298386012736	GIY-YIG motif/motif A; other site
298386012737	putative active site [active]
298386012738	putative metal binding site [ion binding]; other site
298386012739	YaeQ protein; Region: YaeQ; pfam07152
298386012740	Uncharacterized conserved protein [Function unknown]; Region: COG1434
298386012741	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
298386012742	putative active site [active]
298386012743	GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972
298386012744	GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048
298386012745	C-terminal domain interface [polypeptide binding]; other site
298386012746	GSH binding site (G-site) [chemical binding]; other site
298386012747	dimer interface [polypeptide binding]; other site
298386012748	C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291
298386012749	N-terminal domain interface [polypeptide binding]; other site
298386012750	putative dimer interface [polypeptide binding]; other site
298386012751	active site
298386012752	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
298386012753	GST_N family, Saccharomyces cerevisiae GTT2-like subfamily; composed of predominantly uncharacterized proteins with similarity to the S. cerevisiae GST protein, GTT2. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing...; Region: GST_N_GTT2_like; cd03051
298386012754	putative C-terminal domain interface [polypeptide binding]; other site
298386012755	putative GSH binding site (G-site) [chemical binding]; other site
298386012756	putative dimer interface [polypeptide binding]; other site
298386012757	C-terminal, alpha helical domain of GTT2-like Glutathione S-transferases; Region: GST_C_GTT2_like; cd03182
298386012758	putative N-terminal domain interface [polypeptide binding]; other site
298386012759	putative dimer interface [polypeptide binding]; other site
298386012760	putative substrate binding pocket (H-site) [chemical binding]; other site
298386012761	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298386012762	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298386012763	Putative transcription activator [Transcription]; Region: TenA; COG0819
298386012764	NMT1/THI5 like; Region: NMT1; pfam09084
298386012765	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
298386012766	substrate binding pocket [chemical binding]; other site
298386012767	membrane-bound complex binding site; other site
298386012768	hinge residues; other site
298386012769	ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600
298386012770	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386012771	dimer interface [polypeptide binding]; other site
298386012772	conserved gate region; other site
298386012773	putative PBP binding loops; other site
298386012774	ABC-ATPase subunit interface; other site
298386012775	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298386012776	ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116
298386012777	Walker A/P-loop; other site
298386012778	ATP binding site [chemical binding]; other site
298386012779	Q-loop/lid; other site
298386012780	ABC transporter signature motif; other site
298386012781	Walker B; other site
298386012782	D-loop; other site
298386012783	H-loop/switch region; other site
298386012784	4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169
298386012785	dimer interface [polypeptide binding]; other site
298386012786	substrate binding site [chemical binding]; other site
298386012787	ATP binding site [chemical binding]; other site
298386012788	PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; smart00782
298386012789	Uncharacterized Zn-ribbon-containing protein involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnA; COG2824
298386012790	PhnA protein; Region: PhnA; pfam03831
298386012791	Protein of unknown function (DUF3081); Region: DUF3081; pfam11280
298386012792	aromatic amino acid aminotransferase; Provisional; Region: PRK09257
298386012793	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
298386012794	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298386012795	homodimer interface [polypeptide binding]; other site
298386012796	catalytic residue [active]
298386012797	Protein of unknown function (DUF3450); Region: DUF3450; pfam11932
298386012798	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618
298386012799	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618
298386012800	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
298386012801	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
298386012802	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
298386012803	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
298386012804	Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783
298386012805	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
298386012806	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386012807	active site
298386012808	phosphorylation site [posttranslational modification]
298386012809	intermolecular recognition site; other site
298386012810	dimerization interface [polypeptide binding]; other site
298386012811	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298386012812	DNA binding site [nucleotide binding]
298386012813	two-component sensor protein; Provisional; Region: cpxA; PRK09470
298386012814	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298386012815	dimerization interface [polypeptide binding]; other site
298386012816	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298386012817	dimer interface [polypeptide binding]; other site
298386012818	phosphorylation site [posttranslational modification]
298386012819	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386012820	ATP binding site [chemical binding]; other site
298386012821	Mg2+ binding site [ion binding]; other site
298386012822	G-X-G motif; other site
298386012823	Oligoendopeptidase F [Amino acid transport and metabolism]; Region: COG1164
298386012824	Peptidase M3-like family, a zincin metallopeptidase, includes M3 and M32 families; Region: M3_like; cd06258
298386012825	active site
298386012826	Zn binding site [ion binding]; other site
298386012827	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
298386012828	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
298386012829	Glycosyl hydrolases related to GH101 family; Region: GHL; pfam11308
298386012830	Protein of unknown function (DUF2861); Region: DUF2861; pfam11060
298386012831	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
298386012832	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386012833	active site
298386012834	phosphorylation site [posttranslational modification]
298386012835	intermolecular recognition site; other site
298386012836	dimerization interface [polypeptide binding]; other site
298386012837	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298386012838	DNA binding site [nucleotide binding]
298386012839	Domain of unknown function (DUF3404); Region: DUF3404; pfam11884
298386012840	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298386012841	His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512
298386012842	dimer interface [polypeptide binding]; other site
298386012843	phosphorylation site [posttranslational modification]
298386012844	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386012845	ATP binding site [chemical binding]; other site
298386012846	Mg2+ binding site [ion binding]; other site
298386012847	G-X-G motif; other site
298386012848	M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393
298386012849	active site
298386012850	Zn binding site [ion binding]; other site
298386012851	Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063
298386012852	Interdomain contacts; other site
298386012853	Cytokine receptor motif; other site
298386012854	ATP-grasp domain; Region: ATP-grasp_4; cl17255
298386012855	ATP-grasp domain; Region: ATP-grasp_4; cl17255
298386012856	Acetylornithine deacetylase/Succinyl-diaminopimelate desuccinylase and related deacylases [Amino acid transport and metabolism]; Region: ArgE; COG0624
298386012857	M20 Peptidase Glutamate carboxypeptidase, a periplasmic enzyme; Region: M20_CPDG2; cd03885
298386012858	metal binding site [ion binding]; metal-binding site
298386012859	dimer interface [polypeptide binding]; other site
298386012860	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386012861	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386012862	LysR substrate binding domain; Region: LysR_substrate; pfam03466
298386012863	dimerization interface [polypeptide binding]; other site
298386012864	ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839
298386012865	The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301
298386012866	Walker A/P-loop; other site
298386012867	ATP binding site [chemical binding]; other site
298386012868	Q-loop/lid; other site
298386012869	ABC transporter signature motif; other site
298386012870	Walker B; other site
298386012871	D-loop; other site
298386012872	H-loop/switch region; other site
298386012873	ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395
298386012874	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386012875	dimer interface [polypeptide binding]; other site
298386012876	conserved gate region; other site
298386012877	putative PBP binding loops; other site
298386012878	ABC-ATPase subunit interface; other site
298386012879	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386012880	dimer interface [polypeptide binding]; other site
298386012881	conserved gate region; other site
298386012882	putative PBP binding loops; other site
298386012883	ABC-ATPase subunit interface; other site
298386012884	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
298386012885	Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416
298386012886	Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302
298386012887	Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407
298386012888	ligand binding site [chemical binding]; other site
298386012889	ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129
298386012890	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
298386012891	Walker A/P-loop; other site
298386012892	ATP binding site [chemical binding]; other site
298386012893	Q-loop/lid; other site
298386012894	ABC transporter signature motif; other site
298386012895	Walker B; other site
298386012896	D-loop; other site
298386012897	H-loop/switch region; other site
298386012898	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
298386012899	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
298386012900	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
298386012901	TM-ABC transporter signature motif; other site
298386012902	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
298386012903	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
298386012904	TM-ABC transporter signature motif; other site
298386012905	Ribulose kinase [Energy production and conversion]; Region: AraB; COG1069
298386012906	Yersinia Pseudotuberculosis carbohydrate kinase-like subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_YpCarbK_like; cd07782
298386012907	N- and C-terminal domain interface [polypeptide binding]; other site
298386012908	active site
298386012909	MgATP binding site [chemical binding]; other site
298386012910	catalytic site [active]
298386012911	metal binding site [ion binding]; metal-binding site
298386012912	carbohydrate binding site [chemical binding]; other site
298386012913	putative homodimer interface [polypeptide binding]; other site
298386012914	This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079
298386012915	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298386012916	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298386012917	metal binding site [ion binding]; metal-binding site
298386012918	active site
298386012919	I-site; other site
298386012920	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
298386012921	DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216
298386012922	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386012923	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
298386012924	substrate binding pocket [chemical binding]; other site
298386012925	dimerization interface [polypeptide binding]; other site
298386012926	Helix-turn-helix domain; Region: HTH_18; pfam12833
298386012927	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
298386012928	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
298386012929	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386012930	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
298386012931	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
298386012932	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
298386012933	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
298386012934	Nuclear transport factor 2 (NTF2-like) superfamily. This family includes members of the NTF2 family, Delta-5-3-ketosteroid isomerases, Scytalone Dehydratases, and the beta subunit of Ring hydroxylating dioxygenases. This family is a classic example of...; Region: NTF2_like; cl09109
298386012935	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
298386012936	FAD binding domain; Region: FAD_binding_4; pfam01565
298386012937	FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277
298386012938	FAD binding domain; Region: FAD_binding_4; pfam01565
298386012939	Berberine and berberine like; Region: BBE; pfam08031
298386012940	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
298386012941	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
298386012942	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
298386012943	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
298386012944	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
298386012945	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386012946	SlyX; Region: SlyX; cl01090
298386012947	Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247
298386012948	Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_31; cd04690
298386012949	nudix motif; other site
298386012950	putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419
298386012951	TMAO/DMSO reductase; Reviewed; Region: PRK05363
298386012952	Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199
298386012953	Moco binding site; other site
298386012954	metal coordination site [ion binding]; other site
298386012955	Fatty acid desaturase; Region: FA_desaturase; pfam00487
298386012956	The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505
298386012957	Di-iron ligands [ion binding]; other site
298386012958	L,D-transpeptidase; Provisional; Region: PRK10190
298386012959	Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118
298386012960	L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734
298386012961	Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238; cl11539
298386012962	SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968
298386012963	Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999
298386012964	Cu(I) binding site [ion binding]; other site
298386012965	Domain of unknown function (DUF368); Region: DUF368; pfam04018
298386012966	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298386012967	HAMP domain; Region: HAMP; pfam00672
298386012968	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298386012969	dimer interface [polypeptide binding]; other site
298386012970	phosphorylation site [posttranslational modification]
298386012971	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386012972	ATP binding site [chemical binding]; other site
298386012973	Mg2+ binding site [ion binding]; other site
298386012974	G-X-G motif; other site
298386012975	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
298386012976	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386012977	active site
298386012978	phosphorylation site [posttranslational modification]
298386012979	intermolecular recognition site; other site
298386012980	dimerization interface [polypeptide binding]; other site
298386012981	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298386012982	DNA binding site [nucleotide binding]
298386012983	undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714
298386012984	Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187
298386012985	Ligand binding site; other site
298386012986	Putative Catalytic site; other site
298386012987	DXD motif; other site
298386012988	4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807
298386012989	Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364
298386012990	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298386012991	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
298386012992	active site
298386012993	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386012994	proteobacterial dedicated sortase system histidine kinase; Region: marine_sort_HK; TIGR03785
298386012995	DOMON-like type 9 carbohydrate binding module at the N-terminus of bacterial sensor histidine kinases; Region: CBM9_like_HisKa; cd09622
298386012996	putative ligand binding site [chemical binding]; other site
298386012997	HAMP domain; Region: HAMP; pfam00672
298386012998	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298386012999	dimer interface [polypeptide binding]; other site
298386013000	phosphorylation site [posttranslational modification]
298386013001	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386013002	ATP binding site [chemical binding]; other site
298386013003	Mg2+ binding site [ion binding]; other site
298386013004	G-X-G motif; other site
298386013005	proteobacterial dedicated sortase system response regulator; Region: marine_sort_RR; TIGR03787
298386013006	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386013007	active site
298386013008	phosphorylation site [posttranslational modification]
298386013009	intermolecular recognition site; other site
298386013010	dimerization interface [polypeptide binding]; other site
298386013011	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298386013012	DNA binding site [nucleotide binding]
298386013013	proteobacterial sortase system OmpA family protein; Region: pdsO; TIGR03789
298386013014	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
298386013015	ligand binding site [chemical binding]; other site
298386013016	FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784
298386013017	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386013018	active site
298386013019	phosphorylation site [posttranslational modification]
298386013020	intermolecular recognition site; other site
298386013021	dimerization interface [polypeptide binding]; other site
298386013022	Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835
298386013023	putative NADPH-dependent glutamate synthase small subunit; Provisional; Region: PRK12814
298386013024	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
298386013025	catalytic loop [active]
298386013026	iron binding site [ion binding]; other site
298386013027	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
298386013028	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
298386013029	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
298386013030	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
298386013031	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753
298386013032	formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591
298386013033	[4Fe-4S] binding site [ion binding]; other site
298386013034	molybdopterin cofactor binding site; other site
298386013035	Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790
298386013036	molybdopterin cofactor binding site; other site
298386013037	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
298386013038	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298386013039	active site
298386013040	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386013041	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386013042	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
298386013043	putative effector binding pocket; other site
298386013044	dimerization interface [polypeptide binding]; other site
298386013045	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
298386013046	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298386013047	putative substrate translocation pore; other site
298386013048	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298386013049	DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519
298386013050	Isochorismatase family; Region: Isochorismatase; pfam00857
298386013051	YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012
298386013052	catalytic triad [active]
298386013053	dimer interface [polypeptide binding]; other site
298386013054	conserved cis-peptide bond; other site
298386013055	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386013056	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386013057	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
298386013058	dimerization interface [polypeptide binding]; other site
298386013059	NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210
298386013060	NAD/NADP octopine/nopaline dehydrogenase, alpha-helical domain; Region: Octopine_DH; pfam02317
298386013061	Predicted membrane protein [Function unknown]; Region: COG1288
298386013062	C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606
298386013063	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
298386013064	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
298386013065	Protein Kinases, catalytic domain; Region: PKc_like; cl09925
298386013066	ABC-type phosphate/phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG3638
298386013067	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298386013068	Walker A/P-loop; other site
298386013069	ATP binding site [chemical binding]; other site
298386013070	ABC transporter signature motif; other site
298386013071	Walker B; other site
298386013072	D-loop; other site
298386013073	H-loop/switch region; other site
298386013074	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
298386013075	Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890
298386013076	putative active site [active]
298386013077	putative metal binding residues [ion binding]; other site
298386013078	signature motif; other site
298386013079	putative triphosphate binding site [ion binding]; other site
298386013080	dimer interface [polypeptide binding]; other site
298386013081	M20 Peptidase T like enzymes specifically cleave tripeptides; Region: M20_peptT_like; cd05683
298386013082	peptidase T-like protein; Region: PepT-like; TIGR01883
298386013083	metal binding site [ion binding]; metal-binding site
298386013084	putative dimer interface [polypeptide binding]; other site
298386013085	Protein of unknown function (DUF3392); Region: DUF3392; pfam11872
298386013086	hypothetical protein; Provisional; Region: PRK09256
298386013087	Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186
298386013088	Peptidase M14 Aspartoacylase (ASPA) subfamily; Region: M14_ASPA; cd06909
298386013089	Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952
298386013090	active site
298386013091	Zn binding site [ion binding]; other site
298386013092	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298386013093	This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_10; cd07251
298386013094	EamA-like transporter family; Region: EamA; pfam00892
298386013095	Dopa 4,5-dioxygenase family; Region: DOPA_dioxygen; pfam08883
298386013096	Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244
298386013097	Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440
298386013098	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
298386013099	Nitroreductase-like family 1. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_1; cd02137
298386013100	dimer interface [polypeptide binding]; other site
298386013101	FMN binding site [chemical binding]; other site
298386013102	Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer,  utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cl00514
298386013103	dimer interface [polypeptide binding]; other site
298386013104	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
298386013105	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
298386013106	The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507
298386013107	D-alanyl-D-alanine carboxypeptidase [Cell envelope biogenesis, outer membrane]; Region: DacC; COG1686
298386013108	Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872
298386013109	Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943
298386013110	Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055
298386013111	NHAD transporter family protein; Provisional; Region: PLN00137; cl17324
298386013112	Lipid A 3-O-deacylase (PagL); Region: PagL; pfam09411
298386013113	Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008
298386013114	Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I).  TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502
298386013115	tetramer interface [polypeptide binding]; other site
298386013116	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298386013117	catalytic residue [active]
298386013118	RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808
298386013119	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
298386013120	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
298386013121	putative active site [active]
298386013122	putative nucleic acid binding site [nucleotide binding]; other site
298386013123	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
298386013124	non-haem dioxygenase in morphine synthesis N-terminal; Region: DIOX_N; pfam14226
298386013125	Isopenicillin N synthase and related dioxygenases [General function prediction only]; Region: PcbC; COG3491
298386013126	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy; pfam03171
298386013127	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298386013128	Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281
298386013129	active site
298386013130	multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575
298386013131	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
298386013132	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
298386013133	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
298386013134	putative active site [active]
298386013135	putative NTP binding site [chemical binding]; other site
298386013136	putative nucleic acid binding site [nucleotide binding]; other site
298386013137	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
298386013138	NodN (nodulation factor N) contains a single hot dog fold similar to those of the peroxisomal Hydratase-Dehydrogenase-Epimerase (HDE) protein, and the fatty acid synthase beta subunit.  Rhizobium and related species form nodules on the roots of their...; Region: NodN; cd03450
298386013139	putative active site [active]
298386013140	putative catalytic site [active]
298386013141	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
298386013142	Beta-lactamase; Region: Beta-lactamase; pfam00144
298386013143	Domain of unknown function; Region: DUF331; pfam03889
298386013144	Metal-dependent hydrolases of the beta-lactamase superfamily II [General function prediction only]; Region: COG1237
298386013145	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386013146	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
298386013147	Predicted ATPase of the ABC class; Region: ABC_ATPase; pfam09818
298386013148	protein-export membrane protein SecD; Region: secD; TIGR01129
298386013149	Predicted acetyltransferase [General function prediction only]; Region: COG2388
298386013150	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386013151	thioredoxin 2; Provisional; Region: PRK10996
298386013152	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
298386013153	catalytic residues [active]
298386013154	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
298386013155	Cation efflux family; Region: Cation_efflux; cl00316
298386013156	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
298386013157	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
298386013158	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
298386013159	beta-hexosaminidase; Provisional; Region: PRK05337
298386013160	Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472
298386013161	Protein of unknown function (DUF1097); Region: DUF1097; pfam06496
298386013162	DDE superfamily endonuclease; Region: DDE_3; pfam13358
298386013163	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
298386013164	Homeodomain-like domain; Region: HTH_23; pfam13384
298386013165	Winged helix-turn helix; Region: HTH_29; pfam13551
298386013166	Winged helix-turn helix; Region: HTH_33; pfam13592
298386013167	DDE superfamily endonuclease; Region: DDE_3; pfam13358
298386013168	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
298386013169	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386013170	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386013171	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
298386013172	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
298386013173	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
298386013174	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
298386013175	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
298386013176	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386013177	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
298386013178	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386013179	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
298386013180	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
298386013181	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
298386013182	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386013183	Domain of unknown function (DUF1870); Region: DUF1870; pfam08965
298386013184	Homeodomain-like domain; Region: HTH_23; pfam13384
298386013185	Winged helix-turn helix; Region: HTH_29; pfam13551
298386013186	Winged helix-turn helix; Region: HTH_33; pfam13592
298386013187	DDE superfamily endonuclease; Region: DDE_3; pfam13358
298386013188	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
298386013189	sensor protein PhoQ; Provisional; Region: PRK10815
298386013190	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386013191	ATP binding site [chemical binding]; other site
298386013192	Mg2+ binding site [ion binding]; other site
298386013193	G-X-G motif; other site
298386013194	Response regulator receiver domain; Region: Response_reg; pfam00072
298386013195	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386013196	active site
298386013197	phosphorylation site [posttranslational modification]
298386013198	intermolecular recognition site; other site
298386013199	dimerization interface [polypeptide binding]; other site
298386013200	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298386013201	DNA binding site [nucleotide binding]
298386013202	Predicted membrane protein [Function unknown]; Region: COG3212
298386013203	Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413
298386013204	Regulator of nitric oxide reductase transcription [Transcription]; Region: NosR; COG3901
298386013205	4Fe-4S binding domain; Region: Fer4_5; pfam12801
298386013206	Polyferredoxin [Energy production and conversion]; Region: NapH; COG0348
298386013207	4Fe-4S binding domain; Region: Fer4_5; pfam12801
298386013208	nitrous-oxide reductase; Validated; Region: PRK02888
298386013209	Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116
298386013210	nitrous oxide reductase family maturation protein NosD; Region: NosD_copper_fam; TIGR04247
298386013211	ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131
298386013212	ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230
298386013213	Walker A/P-loop; other site
298386013214	ATP binding site [chemical binding]; other site
298386013215	Q-loop/lid; other site
298386013216	ABC transporter signature motif; other site
298386013217	Walker B; other site
298386013218	D-loop; other site
298386013219	H-loop/switch region; other site
298386013220	ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679
298386013221	NosL; Region: NosL; pfam05573
298386013222	Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760
298386013223	PPIC-type PPIASE domain; Region: Rotamase_2; cl08278
298386013224	leucine transcriptional activator; Reviewed; Region: leuO; PRK09508
298386013225	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386013226	The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466
298386013227	putative substrate binding pocket [chemical binding]; other site
298386013228	putative dimerization interface [polypeptide binding]; other site
298386013229	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
298386013230	Transcriptional regulatory protein, C terminal; Region: Trans_reg_C; smart00862
298386013231	DNA binding site [nucleotide binding]
298386013232	Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741
298386013233	GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518
298386013234	catalytic triad [active]
298386013235	Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454
298386013236	Iron-containing alcohol dehydrogenases-like, involved in the linear alkylbenzenesulfonate (LAS) degradation pathway; Region: Fe-ADH7; cd08192
298386013237	putative active site [active]
298386013238	metal binding site [ion binding]; metal-binding site
298386013239	NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012
298386013240	Uncharacterized aldehyde dehydrogenase of Synechococcus sp. PCC 7335 (EDX86601); Region: ALDH_EDX86601; cd07102
298386013241	NAD(P) binding site [chemical binding]; other site
298386013242	catalytic residues [active]
298386013243	Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174
298386013244	Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120
298386013245	Cytochrome c; Region: Cytochrom_C; pfam00034
298386013246	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
298386013247	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
298386013248	Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083
298386013249	putative catalytic site [active]
298386013250	putative metal binding site [ion binding]; other site
298386013251	putative phosphate binding site [ion binding]; other site
298386013252	Protein of unkown function (DUF1881); Region: DUF1881; pfam08964
298386013253	Beta/Gamma crystallin; Region: Crystall; cl02528
298386013254	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
298386013255	active site
298386013256	catalytic site [active]
298386013257	DDE superfamily endonuclease; Region: DDE_3; pfam13358
298386013258	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
298386013259	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386013260	Homeodomain-like domain; Region: HTH_23; pfam13384
298386013261	Winged helix-turn helix; Region: HTH_29; pfam13551
298386013262	Homeodomain-like domain; Region: HTH_32; pfam13565
298386013263	Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648
298386013264	Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241
298386013265	Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414
298386013266	S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304
298386013267	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
298386013268	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
298386013269	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
298386013270	active site
298386013271	Int/Topo IB signature motif; other site
298386013272	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
298386013273	Putative transposase; Region: Y2_Tnp; pfam04986
298386013274	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
298386013275	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
298386013276	HlyD family secretion protein; Region: HlyD_3; pfam13437
298386013277	The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915
298386013278	Protein export membrane protein; Region: SecD_SecF; cl14618
298386013279	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190
298386013280	active site
298386013281	substrate binding sites [chemical binding]; other site
298386013282	Bacterial protein of unknown function (DUF925); Region: DUF925; pfam06042
298386013283	Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982
298386013284	Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508
298386013285	Protein of unknown function (DUF1778); Region: DUF1778; pfam08681
298386013286	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386013287	3-mercaptopyruvate sulfurtransferase; Region: PLN02723
298386013288	Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448
298386013289	active site residue [active]
298386013290	Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449
298386013291	active site residue [active]
298386013292	PBP superfamily domain; Region: PBP_like_2; cl17296
298386013293	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298386013294	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298386013295	metal binding site [ion binding]; metal-binding site
298386013296	active site
298386013297	I-site; other site
298386013298	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386013299	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386013300	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189
298386013301	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
298386013302	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
298386013303	substrate binding pocket [chemical binding]; other site
298386013304	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
298386013305	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
298386013306	membrane-bound complex binding site; other site
298386013307	hinge residues; other site
298386013308	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
298386013309	Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_1; cd07020
298386013310	dimer interface [polypeptide binding]; other site
298386013311	active site residues [active]
298386013312	Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030
298386013313	Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763
298386013314	NfeD-like C-terminal, partner-binding; Region: NfeD; pfam01957
298386013315	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
298386013316	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
298386013317	23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727
298386013318	Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971
298386013319	Protein of unknown function (DUF3833); Region: DUF3833; pfam12915
298386013320	Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593
298386013321	Protein of unknown function (DUF2813); Region: DUF2813; pfam11398
298386013322	TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family.  The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026
298386013323	putative active site [active]
298386013324	putative metal-binding site [ion binding]; other site
298386013325	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298386013326	Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233
298386013327	dimer interface [polypeptide binding]; other site
298386013328	active site
298386013329	metal binding site [ion binding]; metal-binding site
298386013330	glutathione binding site [chemical binding]; other site
298386013331	5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737
298386013332	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
298386013333	active site
298386013334	metal binding site [ion binding]; metal-binding site
298386013335	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
298386013336	3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353
298386013337	3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108
298386013338	Transcriptional activator HlyU; Region: HlyU; pfam10115
298386013339	NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424
298386013340	Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304
298386013341	ligand binding site [chemical binding]; other site
298386013342	homodimer interface [polypeptide binding]; other site
298386013343	NAD(P) binding site [chemical binding]; other site
298386013344	trimer interface B [polypeptide binding]; other site
298386013345	trimer interface A [polypeptide binding]; other site
298386013346	Domain of unknown function (DUF3814); Region: DUF3814; pfam12769
298386013347	pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444
298386013348	NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233
298386013349	Domain of unknown function (DUF3404); Region: DUF3404; pfam11884
298386013350	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298386013351	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298386013352	dimer interface [polypeptide binding]; other site
298386013353	phosphorylation site [posttranslational modification]
298386013354	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386013355	ATP binding site [chemical binding]; other site
298386013356	Mg2+ binding site [ion binding]; other site
298386013357	G-X-G motif; other site
298386013358	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
298386013359	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386013360	active site
298386013361	phosphorylation site [posttranslational modification]
298386013362	intermolecular recognition site; other site
298386013363	dimerization interface [polypeptide binding]; other site
298386013364	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298386013365	DNA binding site [nucleotide binding]
298386013366	Protein of unknown function (DUF2861); Region: DUF2861; pfam11060
298386013367	NnrS protein; Region: NnrS; pfam05940
298386013368	Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317
298386013369	HD domain; Region: HD_4; pfam13328
298386013370	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
298386013371	NAD synthase [Coenzyme metabolism]; Region: NadE; COG0171
298386013372	NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553
298386013373	homodimer interface [polypeptide binding]; other site
298386013374	NAD binding pocket [chemical binding]; other site
298386013375	ATP binding pocket [chemical binding]; other site
298386013376	Mg binding site [ion binding]; other site
298386013377	active-site loop [active]
298386013378	nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071
298386013379	Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165
298386013380	active site
298386013381	(T/H)XGH motif; other site
298386013382	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
298386013383	Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185
298386013384	putative acyl-acceptor binding pocket; other site
298386013385	Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185
298386013386	Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885
298386013387	ligand binding site [chemical binding]; other site
298386013388	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386013389	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845
298386013390	Domain of unknown function (DUF4344); Region: DUF4344; pfam14247
298386013391	putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074
298386013392	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386013393	The C-terminal substrate binding domain of LysR-type transcriptional regulator, HupR, which regulates expression of the heme uptake receptor HupA; contains the type 2 periplasmic binding fold; Region: PBP2_HupR; cd08431
298386013394	putative dimerization interface [polypeptide binding]; other site
298386013395	Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042
298386013396	CoA binding domain; Region: CoA_binding_2; pfam13380
298386013397	Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607
298386013398	ATP-grasp domain; Region: ATP-grasp_5; pfam13549
298386013399	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
298386013400	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
298386013401	DDE superfamily endonuclease; Region: DDE_3; pfam13358
298386013402	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
298386013403	Homeodomain-like domain; Region: HTH_23; pfam13384
298386013404	Winged helix-turn helix; Region: HTH_29; pfam13551
298386013405	Winged helix-turn helix; Region: HTH_33; pfam13592
298386013406	Sporulation related domain; Region: SPOR; pfam05036
298386013407	maltose O-acetyltransferase; Provisional; Region: PRK10092
298386013408	Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357
298386013409	active site
298386013410	substrate binding site [chemical binding]; other site
298386013411	trimer interface [polypeptide binding]; other site
298386013412	CoA binding site [chemical binding]; other site
298386013413	D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966
298386013414	D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820
298386013415	ATP-grasp domain; Region: ATP-grasp_4; cl17255
298386013416	Fic/DOC family; Region: Fic; cl00960
298386013417	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
298386013418	active site
298386013419	DNA binding site [nucleotide binding]
298386013420	Int/Topo IB signature motif; other site
298386013421	Protein of unknown function (DUF3319); Region: DUF3319; pfam11782
298386013422	Protein of unknown function (DUF3319); Region: DUF3319; pfam11782
298386013423	Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682
298386013424	Haloacid dehalogenase-like hydrolase; Region: HAD_2; pfam13419
298386013425	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
298386013426	motif II; other site
298386013427	translation initiation factor Sui1; Validated; Region: PRK06824
298386013428	Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567
298386013429	putative rRNA binding site [nucleotide binding]; other site
298386013430	Phage protein; Region: DUF3653; pfam12375
298386013431	virion protein; Provisional; Region: V; PHA02564
298386013432	Homeodomain-like domain; Region: HTH_23; pfam13384
298386013433	Winged helix-turn helix; Region: HTH_29; pfam13551
298386013434	Winged helix-turn helix; Region: HTH_33; pfam13592
298386013435	DDE superfamily endonuclease; Region: DDE_3; pfam13358
298386013436	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
298386013437	AAA-like domain; Region: AAA_10; pfam12846
298386013438	HerA helicase [Replication, recombination, and repair]; Region: COG0433
298386013439	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298386013440	sequence-specific DNA binding site [nucleotide binding]; other site
298386013441	salt bridge; other site
298386013442	Homeodomain-like domain; Region: HTH_23; cl17451
298386013443	Winged helix-turn helix; Region: HTH_29; pfam13551
298386013444	Antitoxin Phd_YefM, type II toxin-antitoxin system; Region: PhdYeFM_antitox; pfam02604
298386013445	Plasmid encoded toxin Txe; Region: Plasmid_Txe; cl17389
298386013446	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
298386013447	Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599
298386013448	Cupin domain; Region: Cupin_2; pfam07883
298386013449	RNA polymerase sigma factor RpoS; Region: rpoS_proteo; TIGR02394
298386013450	Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140
298386013451	Sigma-70 region 2; Region: Sigma70_r2; pfam04542
298386013452	Sigma-70 region 3; Region: Sigma70_r3; pfam04539
298386013453	Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171
298386013454	DNA binding residues [nucleotide binding]
298386013455	Protein of unknown function (DUF1439); Region: DUF1439; pfam07273
298386013456	Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059
298386013457	chromate transporter, chromate ion transporter (CHR) family; Region: 2A51; TIGR00937
298386013458	Chromate transporter; Region: Chromate_transp; pfam02417
298386013459	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386013460	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386013461	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
298386013462	putative effector binding pocket; other site
298386013463	dimerization interface [polypeptide binding]; other site
298386013464	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386013465	Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914
298386013466	Dicarboxylate transport; Region: DctA-YdbH; pfam11739
298386013467	YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617
298386013468	Protein of unknown function (DUF1318); Region: DUF1318; pfam07027
298386013469	Conserved hypothetical protein 698; Region: Cons_hypoth698; cl01075
298386013470	DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609
298386013471	umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700
298386013472	active site
298386013473	DNA binding site [nucleotide binding]
298386013474	Domain of unknown function (DUF4113); Region: DUF4113; pfam13438
298386013475	SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974
298386013476	Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529
298386013477	Catalytic site [active]
298386013478	Sporulation related domain; Region: SPOR; pfam05036
298386013479	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
298386013480	Protein of unknown function (DUF1566); Region: DUF1566; pfam07603
298386013481	Peptidase M36 family also known as fungalysin family; Region: M36; cd09596
298386013482	Zn binding site [ion binding]; other site
298386013483	Proprotein convertase P-domain; Region: P_proprotein; pfam01483
298386013484	TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785
298386013485	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
298386013486	N-terminal plug; other site
298386013487	ligand-binding site [chemical binding]; other site
298386013488	Protease II [Amino acid transport and metabolism]; Region: PtrB; COG1770
298386013489	Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326
298386013490	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131
298386013491	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
298386013492	cation binding site [ion binding]; other site
298386013493	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
298386013494	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386013495	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
298386013496	dimerization interface [polypeptide binding]; other site
298386013497	helicase 45; Provisional; Region: PTZ00424
298386013498	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
298386013499	ATP binding site [chemical binding]; other site
298386013500	Mg++ binding site [ion binding]; other site
298386013501	motif III; other site
298386013502	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
298386013503	nucleotide binding region [chemical binding]; other site
298386013504	ATP-binding site [chemical binding]; other site
298386013505	UDP-galactose-4-epimerase; Provisional; Region: PRK10675
298386013506	UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247
298386013507	NAD binding site [chemical binding]; other site
298386013508	homodimer interface [polypeptide binding]; other site
298386013509	active site
298386013510	substrate binding site [chemical binding]; other site
298386013511	Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596
298386013512	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298386013513	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298386013514	metal binding site [ion binding]; metal-binding site
298386013515	active site
298386013516	I-site; other site
298386013517	nudix-type nucleoside diphosphatase, YffH/AdpP family; Region: TIGR00052
298386013518	ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424
298386013519	dimer interface [polypeptide binding]; other site
298386013520	ADP-ribose binding site [chemical binding]; other site
298386013521	active site
298386013522	nudix motif; other site
298386013523	metal binding site [ion binding]; metal-binding site
298386013524	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
298386013525	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
298386013526	Coenzyme A binding pocket [chemical binding]; other site
298386013527	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386013528	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298386013529	TPR motif; other site
298386013530	TPR repeat; Region: TPR_11; pfam13414
298386013531	binding surface
298386013532	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
298386013533	Uncharacterized conserved protein [Function unknown]; Region: COG1434
298386013534	putative active site [active]
298386013535	cobyric acid synthase; Provisional; Region: PRK00784
298386013536	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
298386013537	Type 1 glutamine amidotransferase (GATase1) domain found in Cobyric Acid Synthase (CobQ); Region: GATase1_CobQ; cd01750
298386013538	catalytic triad [active]
298386013539	Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067
298386013540	catalytic core [active]
298386013541	Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544
298386013542	homotrimer interface [polypeptide binding]; other site
298386013543	Walker A motif; other site
298386013544	GTP binding site [chemical binding]; other site
298386013545	Walker B motif; other site
298386013546	CAAX protease self-immunity; Region: Abi; pfam02517
298386013547	Bacterial OB fold (BOF) protein; Region: BOF; cl01196
298386013548	Helix-hairpin-helix motif; Region: HHH_3; pfam12836
298386013549	Protein of unknown function (DUF962); Region: DUF962; cl01879
298386013550	3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427
298386013551	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
298386013552	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
298386013553	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Deinococcus radiodurans DR2231 protein and its bacterial homologs; Region: NTP-PPase_DR2231_like; cd11530
298386013554	metal binding site [ion binding]; metal-binding site
298386013555	HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484
298386013556	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
298386013557	active site
298386013558	motif I; other site
298386013559	motif II; other site
298386013560	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
298386013561	catalytic site [active]
298386013562	active site
298386013563	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
298386013564	NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025
298386013565	ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192
298386013566	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
298386013567	ATP binding site [chemical binding]; other site
298386013568	Mg++ binding site [ion binding]; other site
298386013569	motif III; other site
298386013570	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
298386013571	nucleotide binding region [chemical binding]; other site
298386013572	ATP-binding site [chemical binding]; other site
298386013573	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
298386013574	Guanosine kinase-like sugar kinases.  Found in bacteria and archaea, the guanosine kinase-like group is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: Guanosine_kinase_like; cd01947
298386013575	substrate binding site [chemical binding]; other site
298386013576	ATP binding site [chemical binding]; other site
298386013577	ABC transporter, phosphonate, periplasmic substrate-binding protein; Region: Phosphonate-bd; pfam12974
298386013578	TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122
298386013579	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298386013580	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298386013581	dimer interface [polypeptide binding]; other site
298386013582	phosphorylation site [posttranslational modification]
298386013583	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386013584	ATP binding site [chemical binding]; other site
298386013585	Mg2+ binding site [ion binding]; other site
298386013586	G-X-G motif; other site
298386013587	Response regulator receiver domain; Region: Response_reg; pfam00072
298386013588	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386013589	active site
298386013590	phosphorylation site [posttranslational modification]
298386013591	intermolecular recognition site; other site
298386013592	dimerization interface [polypeptide binding]; other site
298386013593	"elongating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type I and II and polyketide synthases.They are characterized by the utlization of acyl carrier protein (ACP)...; Region: elong_cond_enzymes; cd00828
298386013594	3-oxoacyl-(acyl-carrier-protein) synthase [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: FabB; COG0304
298386013595	active site
298386013596	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
298386013597	AraC transcriptional regulators having a Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_2; cd03138
298386013598	conserved cys residue [active]
298386013599	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298386013600	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298386013601	Family 41 Carbohydrate-Binding Module from pullulanase-like enzymes; Region: CBM41_pullulanase; cd10315
298386013602	carbohydrate binding site [chemical binding]; other site
298386013603	alpha-1,6-glucosidases, pullulanase-type; Region: pullul_strch; TIGR02103
298386013604	Early set domain associated with the catalytic domain of pullulanase (also called dextrinase and alpha-dextrin endo-1,6-alpha glucosidase); Region: E_set_Pullulanase; cd02860
298386013605	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
298386013606	Alpha amylase catalytic domain found in Pullulanase (also called dextrinase; alpha-dextrin endo-1,6-alpha glucosidase), limit dextrinase, and related proteins; Region: AmyAc_Pullulanase_LD-like; cd11341
298386013607	Ca binding site [ion binding]; other site
298386013608	active site
298386013609	catalytic site [active]
298386013610	Domain of unknown function (DUF3372); Region: DUF3372; pfam11852
298386013611	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386013612	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386013613	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
298386013614	dimerization interface [polypeptide binding]; other site
298386013615	Deoxycytidylate deaminase domain. Deoxycytidylate deaminase catalyzes the deamination of dCMP to dUMP, providing the nucleotide substrate for thymidylate synthase. The enzyme binds Zn++, which is required for catalytic activity. The activity of the...; Region: deoxycytidylate_deaminase; cd01286
298386013616	catalytic motif [active]
298386013617	Zn binding site [ion binding]; other site
298386013618	Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585
298386013619	Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330
298386013620	Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403
298386013621	N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247
298386013622	Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903
298386013623	YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259
298386013624	Uncharacterized conserved protein [Function unknown]; Region: COG1434
298386013625	putative active site [active]
298386013626	16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839
298386013627	S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site;  Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165
298386013628	RNA binding surface [nucleotide binding]; other site
298386013629	Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553
298386013630	active site
298386013631	uracil binding [chemical binding]; other site
298386013632	BCCT family transporter; Region: BCCT; pfam02028
298386013633	Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111
298386013634	PLD-like domain; Region: PLDc_2; pfam13091
298386013635	putative active site [active]
298386013636	catalytic site [active]
298386013637	Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113
298386013638	PLD-like domain; Region: PLDc_2; pfam13091
298386013639	putative active site [active]
298386013640	catalytic site [active]
298386013641	Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435
298386013642	Uncharacterized conserved protein [Function unknown]; Region: COG3391
298386013643	40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276
298386013644	hypothetical protein; Provisional; Region: PRK07208
298386013645	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450
298386013646	UDP-galactopyranose mutase; Region: GLF; pfam03275
298386013647	Iron permease FTR1 family; Region: FTR1; cl00475
298386013648	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
298386013649	DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220
298386013650	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
298386013651	Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349
298386013652	helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420
298386013653	DeoR C terminal sensor domain; Region: DeoRC; pfam00455
298386013654	Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; pfam08013
298386013655	PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001
298386013656	active site
298386013657	phosphorylation site [posttranslational modification]
298386013658	PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609
298386013659	Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716
298386013660	PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006
298386013661	active pocket/dimerization site; other site
298386013662	active site
298386013663	phosphorylation site [posttranslational modification]
298386013664	N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854
298386013665	N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820
298386013666	active site
298386013667	dimer interface [polypeptide binding]; other site
298386013668	Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947
298386013669	fructose-bisphosphate aldolase; Provisional; Region: PRK09197
298386013670	intersubunit interface [polypeptide binding]; other site
298386013671	active site
298386013672	zinc binding site [ion binding]; other site
298386013673	Na+ binding site [ion binding]; other site
298386013674	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386013675	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386013676	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
298386013677	putative effector binding pocket; other site
298386013678	dimerization interface [polypeptide binding]; other site
298386013679	short chain dehydrogenase; Provisional; Region: PRK07041
298386013680	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298386013681	NAD(P) binding site [chemical binding]; other site
298386013682	active site
298386013683	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
298386013684	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298386013685	putative substrate translocation pore; other site
298386013686	Protein of unknown function (DUF2913); Region: DUF2913; pfam11140
298386013687	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298386013688	substrate binding site [chemical binding]; other site
298386013689	oxyanion hole (OAH) forming residues; other site
298386013690	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298386013691	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cl15762
298386013692	Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583
298386013693	Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670
298386013694	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
298386013695	dimerization interface [polypeptide binding]; other site
298386013696	Cytochrome c; Region: Cytochrom_C; pfam00034
298386013697	Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115
298386013698	Heme-copper oxidase subunit I.  Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane.  The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275
298386013699	D-pathway; other site
298386013700	Low-spin heme binding site [chemical binding]; other site
298386013701	K-pathway; other site
298386013702	Binuclear center (active site) [active]
298386013703	Putative proton exit pathway; other site
298386013704	Putative water exit pathway; other site
298386013705	Nitric oxide reductase activation protein [Inorganic ion transport and metabolism]; Region: NorD; COG4548
298386013706	norD type: Denitrifying bacteria contain both membrane bound and periplasmic nitrate reductases. Denitrification plays a major role  in completing the nitrogen cycle by converting nitrate or nitrite to nitrogen gas. The pathway for microbial...; Region: vWA_norD_type; cd01454
298386013707	MoxR-like ATPases [General function prediction only]; Region: COG0714
298386013708	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298386013709	Walker A motif; other site
298386013710	ATP binding site [chemical binding]; other site
298386013711	Walker B motif; other site
298386013712	CbbQ/NirQ/NorQ C-terminal; Region: CbbQ_C; pfam08406
298386013713	Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; cl01204
298386013714	NorE_like subfamily of heme-copper oxidase subunit III.  Heme-copper oxidases include cytochrome c and ubiquinol oxidases.  Alcaligenes faecalis norE is found in a gene cluster containing norCB. norCB encodes the cytochrome c and cytochrome b subunits of...; Region: NorE_like; cd02862
298386013715	Subunit I/III interface [polypeptide binding]; other site
298386013716	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
298386013717	EamA-like transporter family; Region: EamA; pfam00892
298386013718	EamA-like transporter family; Region: EamA; pfam00892
298386013719	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298386013720	Coenzyme A binding pocket [chemical binding]; other site
298386013721	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632
298386013722	Glutathione-dependent formaldehyde-activating enzyme; Region: GFA; cl01553
298386013723	Uncharacterized conserved protein [Function unknown]; Region: COG1359
298386013724	Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451
298386013725	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298386013726	active site
298386013727	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
298386013728	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
298386013729	Protein of unkown function (DUF1881); Region: DUF1881; pfam08964
298386013730	Beta/Gamma crystallin; Region: Crystall; cl02528
298386013731	Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615
298386013732	active site
298386013733	catalytic site [active]
298386013734	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386013735	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386013736	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386013737	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
298386013738	Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866
298386013739	Peptidase M14-like domain of ATP/GTP binding proteins and cytosolic carboxypeptidases; uncharacterized bacterial subgroup; Region: M14_Nna1_like_1; cd06234
298386013740	putative active site [active]
298386013741	Zn binding site [ion binding]; other site
298386013742	Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007
298386013743	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
298386013744	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
298386013745	Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR9; cd08274
298386013746	NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604
298386013747	putative NAD(P) binding site [chemical binding]; other site
298386013748	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298386013749	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298386013750	Protein of unknown function (DUF535); Region: DUF535; pfam04393
298386013751	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298386013752	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298386013753	dimer interface [polypeptide binding]; other site
298386013754	phosphorylation site [posttranslational modification]
298386013755	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386013756	ATP binding site [chemical binding]; other site
298386013757	Mg2+ binding site [ion binding]; other site
298386013758	G-X-G motif; other site
298386013759	HlyD family secretion protein; Region: HlyD_3; pfam13437
298386013760	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
298386013761	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
298386013762	Protein export membrane protein; Region: SecD_SecF; cl14618
298386013763	Cupin domain; Region: Cupin_2; cl17218
298386013764	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
298386013765	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
298386013766	DNA ligase; Provisional; Region: PRK09125
298386013767	Adenylation domain of kDNA ligases and similar proteins; Region: Adenylation_kDNA_ligase_like; cd07896
298386013768	DNA binding site [nucleotide binding]
298386013769	active site
298386013770	The Oligonucleotide/oligosaccharide binding (OB)-fold domain of kDNA ligase-like ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_kDNA_ligase_like; cd08041
298386013771	DNA binding site [nucleotide binding]
298386013772	pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_x; TIGR03181
298386013773	Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000
298386013774	TPP-binding site [chemical binding]; other site
298386013775	tetramer interface [polypeptide binding]; other site
298386013776	heterodimer interface [polypeptide binding]; other site
298386013777	phosphorylation loop region [posttranslational modification]
298386013778	Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022
298386013779	Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036
298386013780	alpha subunit interface [polypeptide binding]; other site
298386013781	TPP binding site [chemical binding]; other site
298386013782	heterodimer interface [polypeptide binding]; other site
298386013783	Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780
298386013784	branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856
298386013785	Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849
298386013786	E3 interaction surface; other site
298386013787	lipoyl attachment site [posttranslational modification]; other site
298386013788	e3 binding domain; Region: E3_binding; pfam02817
298386013789	2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198
298386013790	electron transfer flavoprotein subunit alpha; Provisional; Region: PLN00022
298386013791	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_alpha; cd01715
298386013792	Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766
298386013793	The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714
298386013794	Ligand binding site [chemical binding]; other site
298386013795	Electron transfer flavoprotein domain; Region: ETF; pfam01012
298386013796	Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644
298386013797	Electron transfer flavoprotein-ubiquinone oxidoreductase; Region: ETF_QO; pfam05187
298386013798	Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366
298386013799	Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893
298386013800	active site
298386013801	catalytic site [active]
298386013802	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
298386013803	Antibiotic biosynthesis monooxygenase; Region: ABM; cl10022
298386013804	Saccharopine Dehydrogenase NAD-binding and catalytic domains; Region: SDH; cd12188
298386013805	active site
298386013806	ligand binding site [chemical binding]; other site
298386013807	homodimer interface [polypeptide binding]; other site
298386013808	NAD(P) binding site [chemical binding]; other site
298386013809	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
298386013810	GST_N family, unknown subfamily 1; composed of uncharacterized proteins, predominantly from bacteria, with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with...; Region: GST_N_1; cd03043
298386013811	putative C-terminal domain interface [polypeptide binding]; other site
298386013812	putative GSH binding site (G-site) [chemical binding]; other site
298386013813	putative dimer interface [polypeptide binding]; other site
298386013814	C-terminal, alpha helical domain of an unknown subfamily 3 of Glutathione S-transferases; Region: GST_C_3; cd03194
298386013815	putative N-terminal domain interface [polypeptide binding]; other site
298386013816	putative dimer interface [polypeptide binding]; other site
298386013817	putative substrate binding pocket (H-site) [chemical binding]; other site
298386013818	hypothetical protein; Provisional; Region: PRK11020
298386013819	3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217
298386013820	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298386013821	NAD(P) binding site [chemical binding]; other site
298386013822	active site
298386013823	6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599
298386013824	3-hydroxyisobutyrate dehydrogenase; Region: HIBADH; TIGR01692
298386013825	3-hydroxyisobutyryl-CoA hydrolase; Provisional; Region: PRK05617
298386013826	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298386013827	substrate binding site [chemical binding]; other site
298386013828	oxyanion hole (OAH) forming residues; other site
298386013829	trimer interface [polypeptide binding]; other site
298386013830	2-enoyl-CoA Hydratase C-terminal region; Region: ECH_C; pfam13766
298386013831	enoyl-CoA hydratase; Provisional; Region: PRK09076
298386013832	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298386013833	substrate binding site [chemical binding]; other site
298386013834	oxyanion hole (OAH) forming residues; other site
298386013835	trimer interface [polypeptide binding]; other site
298386013836	Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960
298386013837	Isobutyryl-CoA dehydrogenase; Region: IBD; cd01162
298386013838	substrate binding pocket [chemical binding]; other site
298386013839	FAD binding site [chemical binding]; other site
298386013840	catalytic base [active]
298386013841	Methylmalonate semialdehyde dehydrogenase and ALDH family members 6A1 and 6B2; Region: ALDH_F6_MMSDH; cd07085
298386013842	methylmalonic acid semialdehyde dehydrogenase; Region: MMSDH; TIGR01722
298386013843	tetrameric interface [polypeptide binding]; other site
298386013844	NAD binding site [chemical binding]; other site
298386013845	catalytic residues [active]
298386013846	acetyl-CoA acetyltransferase; Provisional; Region: PRK06954
298386013847	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
298386013848	dimer interface [polypeptide binding]; other site
298386013849	active site
298386013850	Predicted transcriptional regulators [Transcription]; Region: SoxR; COG0789
298386013851	Helix-Turn-Helix DNA binding domain of the regulatory protein GnyR; Region: HTH_GnyR; cd04776
298386013852	DNA binding residues [nucleotide binding]
298386013853	putative dimer interface [polypeptide binding]; other site
298386013854	Isovaleryl-CoA dehydrogenase; Region: IVD; cd01156
298386013855	isovaleryl-CoA dehydrogenase; Region: PLN02519
298386013856	substrate binding site [chemical binding]; other site
298386013857	FAD binding site [chemical binding]; other site
298386013858	catalytic base [active]
298386013859	Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345
298386013860	3-methylcrotonyl-CoA carboxylase, beta chain; Region: PLN02820
298386013861	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298386013862	substrate binding site [chemical binding]; other site
298386013863	oxyanion hole (OAH) forming residues; other site
298386013864	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298386013865	oxyanion hole (OAH) forming residues; other site
298386013866	trimer interface [polypeptide binding]; other site
298386013867	Isopropylmalate/homocitrate/citramalate synthases [Amino acid transport and metabolism]; Region: LeuA; COG0119
298386013868	3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain; Region: DRE_TIM_HMGL; cd07938
298386013869	active site
298386013870	catalytic residues [active]
298386013871	metal binding site [ion binding]; metal-binding site
298386013872	Autotransporter beta-domain; Region: Autotransporter; smart00869
298386013873	ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136
298386013874	ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255
298386013875	Walker A/P-loop; other site
298386013876	ATP binding site [chemical binding]; other site
298386013877	Q-loop/lid; other site
298386013878	ABC transporter signature motif; other site
298386013879	Walker B; other site
298386013880	D-loop; other site
298386013881	H-loop/switch region; other site
298386013882	ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591
298386013883	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
298386013884	FtsX-like permease family; Region: FtsX; pfam02687
298386013885	MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704
298386013886	ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577
298386013887	FtsX-like permease family; Region: FtsX; pfam02687
298386013888	lysine-arginine-ornithine-binding periplasmic protein; Region: 3A0103s03R; TIGR01096
298386013889	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
298386013890	substrate binding pocket [chemical binding]; other site
298386013891	membrane-bound complex binding site; other site
298386013892	hinge residues; other site
298386013893	histidinol-phosphate aminotransferase; Provisional; Region: PRK01688
298386013894	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
298386013895	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298386013896	homodimer interface [polypeptide binding]; other site
298386013897	catalytic residue [active]
298386013898	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
298386013899	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386013900	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
298386013901	substrate binding pocket [chemical binding]; other site
298386013902	dimerization interface [polypeptide binding]; other site
298386013903	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
298386013904	Transcriptional regulator containing an amidase domain and an AraC-type DNA-binding HTH domain [Transcription]; Region: COG4977
298386013905	AraC transcriptional regulators having an N-terminal Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GATase1_AraC_ArgR_like; cd03136
298386013906	conserved cys residue [active]
298386013907	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298386013908	S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010
298386013909	active site
298386013910	Zn binding site [ion binding]; other site
298386013911	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386013912	Methyltransferase domain; Region: Methyltransf_31; pfam13847
298386013913	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298386013914	S-adenosylmethionine binding site [chemical binding]; other site
298386013915	LTXXQ motif family protein; Region: LTXXQ; pfam07813
298386013916	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298386013917	DNA-binding site [nucleotide binding]; DNA binding site
298386013918	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386013919	Phage-related protein [Function unknown]; Region: COG4695; cl01923
298386013920	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298386013921	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298386013922	metal binding site [ion binding]; metal-binding site
298386013923	active site
298386013924	I-site; other site
298386013925	Winged helix-turn helix; Region: HTH_29; pfam13551
298386013926	Homeodomain-like domain; Region: HTH_32; pfam13565
298386013927	Integrase core domain; Region: rve; pfam00665
298386013928	Integrase core domain; Region: rve_3; pfam13683
298386013929	Transposase; Region: HTH_Tnp_1; cl17663
298386013930	Transposase; Region: HTH_Tnp_1; cl17663
298386013931	CHASE3 domain; Region: CHASE3; pfam05227
298386013932	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386013933	GTPase YlqF; Reviewed; Region: rbgA; PRK09563
298386013934	Circularly permuted YlqF GTPase; Region: YlqF; cd01856
298386013935	GTP/Mg2+ binding site [chemical binding]; other site
298386013936	G4 box; other site
298386013937	G5 box; other site
298386013938	50S ribosome-binding GTPase; Region: MMR_HSR1; pfam01926
298386013939	G1 box; other site
298386013940	Switch I region; other site
298386013941	G2 box; other site
298386013942	G3 box; other site
298386013943	Switch II region; other site
298386013944	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cl17904
298386013945	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298386013946	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298386013947	dimer interface [polypeptide binding]; other site
298386013948	phosphorylation site [posttranslational modification]
298386013949	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386013950	ATP binding site [chemical binding]; other site
298386013951	Mg2+ binding site [ion binding]; other site
298386013952	G-X-G motif; other site
298386013953	Response regulator receiver domain; Region: Response_reg; pfam00072
298386013954	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386013955	active site
298386013956	phosphorylation site [posttranslational modification]
298386013957	intermolecular recognition site; other site
298386013958	dimerization interface [polypeptide binding]; other site
298386013959	fructokinase; Reviewed; Region: PRK09557
298386013960	Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012
298386013961	nucleotide binding site [chemical binding]; other site
298386013962	MarR family; Region: MarR_2; cl17246
298386013963	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
298386013964	Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130
298386013965	Prostaglandin dehydrogenases; Region: PGDH; cd05288
298386013966	NAD(P) binding site [chemical binding]; other site
298386013967	substrate binding site [chemical binding]; other site
298386013968	dimer interface [polypeptide binding]; other site
298386013969	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009
298386013970	Protein of unknown function (DUF330); Region: DUF330; pfam03886
298386013971	paraquat-inducible protein B; Provisional; Region: PRK10807
298386013972	mce related protein; Region: MCE; pfam02470
298386013973	mce related protein; Region: MCE; pfam02470
298386013974	mce related protein; Region: MCE; pfam02470
298386013975	Uncharacterized paraquat-inducible protein A [Function unknown]; Region: PqiA; COG2995
298386013976	Paraquat-inducible protein A; Region: PqiA; pfam04403
298386013977	Paraquat-inducible protein A; Region: PqiA; pfam04403
298386013978	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
298386013979	PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH  (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme.  DCoH stimulates gene expression by...; Region: PCD_DCoH_subfamily_a; cd00913
298386013980	aromatic arch; other site
298386013981	DCoH dimer interaction site [polypeptide binding]; other site
298386013982	DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site
298386013983	DCoH tetramer interaction site [polypeptide binding]; other site
298386013984	substrate binding site [chemical binding]; other site
298386013985	Prokaryotic phenylalanine-4-hydroxylase (pro_PheOH); a member of the biopterin-dependent aromatic amino acid hydroxylase family of non-heme, iron(II)-dependent enzymes that also includes the eukaryotic proteins, phenylalanine-4-hydroxylase (eu_PheOH); Region: pro_PheOH; cd03348
298386013986	cofactor binding site; other site
298386013987	metal binding site [ion binding]; metal-binding site
298386013988	homogentisate 1,2-dioxygenase; Region: HgmA; cl17306
298386013989	2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179
298386013990	Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557
298386013991	GST_N family, Class Zeta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Zeta; cd03042
298386013992	maleylacetoacetate isomerase; Region: maiA; TIGR01262
298386013993	C-terminal domain interface [polypeptide binding]; other site
298386013994	GSH binding site (G-site) [chemical binding]; other site
298386013995	putative dimer interface [polypeptide binding]; other site
298386013996	C-terminal, alpha helical domain of Class Zeta Glutathione S-transferases; Region: GST_C_Zeta; cd03191
298386013997	dimer interface [polypeptide binding]; other site
298386013998	N-terminal domain interface [polypeptide binding]; other site
298386013999	maleylacetoacetate (MAA) substrate binding site (H site) [chemical binding]; other site
298386014000	acetoacetyl-CoA synthetase; Provisional; Region: PRK03584
298386014001	Acetoacetyl-CoA synthetase (acetoacetate-CoA ligase, AACS); Region: AACS; cd05943
298386014002	acyl-activating enzyme (AAE) consensus motif; other site
298386014003	putative AMP binding site [chemical binding]; other site
298386014004	putative active site [active]
298386014005	putative CoA binding site [chemical binding]; other site
298386014006	Putative GTPases (G3E family) [General function prediction only]; Region: COG0523
298386014007	CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492
298386014008	Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833
298386014009	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
298386014010	Predicted Zn-dependent proteases and their inactivated homologs [General function prediction only]; Region: TldD; COG0312
298386014011	ABC-type uncharacterized transport system, duplicated ATPase component [General function prediction only]; Region: COG4172
298386014012	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
298386014013	Walker A/P-loop; other site
298386014014	ATP binding site [chemical binding]; other site
298386014015	Q-loop/lid; other site
298386014016	ABC transporter signature motif; other site
298386014017	Walker B; other site
298386014018	D-loop; other site
298386014019	H-loop/switch region; other site
298386014020	Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352
298386014021	ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257
298386014022	Walker A/P-loop; other site
298386014023	ATP binding site [chemical binding]; other site
298386014024	Q-loop/lid; other site
298386014025	ABC transporter signature motif; other site
298386014026	Walker B; other site
298386014027	D-loop; other site
298386014028	H-loop/switch region; other site
298386014029	Type II (periplasmic) bacterial L-asparaginase; Region: L-asparaginase_II; cd08964
298386014030	active site
298386014031	homodimer interface [polypeptide binding]; other site
298386014032	homotetramer interface [polypeptide binding]; other site
298386014033	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
298386014034	MarR family; Region: MarR; pfam01047
298386014035	peroxiredoxin, Ohr subfamily; Region: organ_hyd_perox; TIGR03561
298386014036	4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586
298386014037	active site
298386014038	4-hydroxyphenylpyruvate dioxygenase and related hemolysins [Amino acid transport and metabolism / General function prediction only]; Region: COG3185
298386014039	N-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HPPD) and hydroxymandelate Synthase (HmaS); Region: HPPD_N_like; cd08342
298386014040	dimer interface [polypeptide binding]; other site
298386014041	C-terminal domain of 4-hydroxyphenylpyruvate dioxygenase (HppD) and hydroxymandelate Synthase (HmaS); Region: HPPD_C_like; cd07250
298386014042	active site
298386014043	Fe binding site [ion binding]; other site
298386014044	CHAD domain; Region: CHAD; pfam05235
298386014045	Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340
298386014046	catalytic residues [active]
298386014047	dimer interface [polypeptide binding]; other site
298386014048	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
298386014049	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
298386014050	active site
298386014051	purine riboside binding site [chemical binding]; other site
298386014052	Domain of unknown function DUF20; Region: UPF0118; pfam01594
298386014053	Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465
298386014054	Protein of unknown function (DUF3087); Region: DUF3087; pfam11286
298386014055	Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826
298386014056	Helix-turn-helix domain; Region: HTH_38; pfam13936
298386014057	Integrase core domain; Region: rve; pfam00665
298386014058	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
298386014059	DNA binding site [nucleotide binding]
298386014060	Int/Topo IB signature motif; other site
298386014061	active site
298386014062	Putative transposase; Region: Y2_Tnp; pfam04986
298386014063	Putative transposase; Region: Y2_Tnp; pfam04986
298386014064	Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668
298386014065	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
298386014066	Transposase; Region: HTH_Tnp_1; cl17663
298386014067	Transposase; Region: HTH_Tnp_1; cl17663
298386014068	Integrase core domain; Region: rve; pfam00665
298386014069	Integrase core domain; Region: rve_3; pfam13683
298386014070	Putative transposase; Region: Y2_Tnp; pfam04986
298386014071	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
298386014072	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
298386014073	Transposase [DNA replication, recombination, and repair]; Region: COG5433
298386014074	Transposase [DNA replication, recombination, and repair]; Region: COG5433
298386014075	Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161
298386014076	Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026
298386014077	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386014078	ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803
298386014079	ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108
298386014080	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
298386014081	ABC-ATPase subunit  interface; other site
298386014082	dimer interface [polypeptide binding]; other site
298386014083	putative PBP binding regions; other site
298386014084	ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121
298386014085	ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235
298386014086	Metal binding protein AcdA.  These proteins have been shown to function in the ABC uptake of Zn2+ and Mn2+ and in competence for genetic transformation and adhesion. The AcdA proteins belong to the TroA superfamily of helical backbone metal receptor...; Region: AdcA; cd01017
298386014087	Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297
298386014088	metal binding site [ion binding]; metal-binding site
298386014089	Domain of unknown function (DUF4198); Region: DUF4198; pfam10670
298386014090	Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029
298386014091	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295
298386014092	PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172
298386014093	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
298386014094	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
298386014095	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298386014096	binding surface
298386014097	TPR motif; other site
298386014098	Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810
298386014099	Gram-negative bacterial tonB protein; Region: TonB; pfam03544
298386014100	Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848
298386014101	Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472
298386014102	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618
298386014103	MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; pfam01618
298386014104	Protein of unknown function (DUF3450); Region: DUF3450; pfam11932
298386014105	TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783
298386014106	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
298386014107	N-terminal plug; other site
298386014108	ligand-binding site [chemical binding]; other site
298386014109	Homeodomain-like domain; Region: HTH_23; pfam13384
298386014110	Winged helix-turn helix; Region: HTH_29; pfam13551
298386014111	Winged helix-turn helix; Region: HTH_33; pfam13592
298386014112	DDE superfamily endonuclease; Region: DDE_3; pfam13358
298386014113	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
298386014114	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
298386014115	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386014116	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
298386014117	dimerization interface [polypeptide binding]; other site
298386014118	AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183
298386014119	dimerization interface [polypeptide binding]; other site
298386014120	cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260
298386014121	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
298386014122	active site
298386014123	HIGH motif; other site
298386014124	nucleotide binding site [chemical binding]; other site
298386014125	nucleotidyl transferase superfamily; Region: nt_trans; cl00015
298386014126	KMSKS motif; other site
298386014127	Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020
298386014128	tRNA binding surface [nucleotide binding]; other site
298386014129	anticodon binding site; other site
298386014130	Pleckstrin homology (PH)-like domains in bacteria (PHb); Region: PH-like_bacteria; cd13225
298386014131	pentamer interface [polypeptide binding]; other site
298386014132	dodecaamer interface [polypeptide binding]; other site
298386014133	Methyltransferase domain; Region: Methyltransf_23; pfam13489
298386014134	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298386014135	S-adenosylmethionine binding site [chemical binding]; other site
298386014136	DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406
298386014137	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
298386014138	active site
298386014139	catalytic site [active]
298386014140	substrate binding site [chemical binding]; other site
298386014141	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
298386014142	Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490
298386014143	putative catalytic site [active]
298386014144	putative metal binding site [ion binding]; other site
298386014145	putative metal binding site [ion binding]; other site
298386014146	putative phosphate binding site [ion binding]; other site
298386014147	ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590
298386014148	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
298386014149	ATP binding site [chemical binding]; other site
298386014150	Mg++ binding site [ion binding]; other site
298386014151	motif III; other site
298386014152	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
298386014153	nucleotide binding region [chemical binding]; other site
298386014154	ATP-binding site [chemical binding]; other site
298386014155	Protein of unknown function (DUF2986); Region: DUF2986; pfam11661
298386014156	Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410
298386014157	Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149
298386014158	active site
298386014159	metal binding site [ion binding]; metal-binding site
298386014160	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
298386014161	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
298386014162	CoenzymeA binding site [chemical binding]; other site
298386014163	subunit interaction site [polypeptide binding]; other site
298386014164	PHB binding site; other site
298386014165	Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275
298386014166	Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes SLAC1 (Slow Anion Channel-Associated 1); Region: TDT_SLAC1_like; cd09323
298386014167	gating phenylalanine in ion channel; other site
298386014168	Predicted DNA-binding proteins [General function prediction only]; Region: COG1342
298386014169	Na+/glutamate symporter [Amino acid transport and metabolism]; Region: GltS; COG0786
298386014170	sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210
298386014171	Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_2; cd03139
298386014172	Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693
298386014173	conserved cys residue [active]
298386014174	Domain of unknown function (DUF1840); Region: DUF1840; pfam08895
298386014175	Rhomboid family; Region: Rhomboid; cl11446
298386014176	Predicted membrane protein [Function unknown]; Region: COG2259
298386014177	Transposase IS200 like; Region: Y1_Tnp; pfam01797
298386014178	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
298386014179	MarR family; Region: MarR_2; pfam12802
298386014180	Domain of Unknown Function with PDB structure (DUF3861); Region: DUF3861; pfam12977
298386014181	methionine sulfoxide reductase A; Provisional; Region: PRK05528
298386014182	enoyl-CoA hydratase; Provisional; Region: PRK07509
298386014183	Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558
298386014184	substrate binding site [chemical binding]; other site
298386014185	oxyanion hole (OAH) forming residues; other site
298386014186	trimer interface [polypeptide binding]; other site
298386014187	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
298386014188	putative DNA binding site [nucleotide binding]; other site
298386014189	putative Zn2+ binding site [ion binding]; other site
298386014190	Domain of unknown function (DUF4136); Region: DUF4136; pfam13590
298386014191	phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261
298386014192	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
298386014193	ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126
298386014194	ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262
298386014195	Walker A/P-loop; other site
298386014196	ATP binding site [chemical binding]; other site
298386014197	Q-loop/lid; other site
298386014198	ABC transporter signature motif; other site
298386014199	Walker B; other site
298386014200	D-loop; other site
298386014201	H-loop/switch region; other site
298386014202	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
298386014203	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386014204	dimer interface [polypeptide binding]; other site
298386014205	conserved gate region; other site
298386014206	putative PBP binding loops; other site
298386014207	ABC-ATPase subunit interface; other site
298386014208	Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of  substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134
298386014209	Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497
298386014210	substrate binding pocket [chemical binding]; other site
298386014211	membrane-bound complex binding site; other site
298386014212	hinge residues; other site
298386014213	ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215
298386014214	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427
298386014215	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386014216	putative PBP binding loops; other site
298386014217	dimer interface [polypeptide binding]; other site
298386014218	ABC-ATPase subunit interface; other site
298386014219	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
298386014220	Patatin-like phospholipase domain containing protein 6, protein 7, and fungal NTE1; Region: Pat_PNPLA6_PNPLA7_NTE1_like; cd07205
298386014221	active site
298386014222	nucleophile elbow; other site
298386014223	Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244
298386014224	Surface antigen; Region: Bac_surface_Ag; pfam01103
298386014225	Glycine cleavage system regulatory protein [Amino acid transport and metabolism]; Region: GcvR; COG2716
298386014226	ACT domain; Region: ACT_6; pfam13740
298386014227	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
298386014228	short chain dehydrogenase; Provisional; Region: PRK08278
298386014229	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298386014230	NAD(P) binding site [chemical binding]; other site
298386014231	active site
298386014232	Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625
298386014233	GST_N family, Omega-like subfamily; composed of uncharacterized proteins with similarity to class Omega GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_Omega_like; cd03060
298386014234	putative GSH binding site (G-site) [chemical binding]; other site
298386014235	active site cysteine [active]
298386014236	putative C-terminal domain interface [polypeptide binding]; other site
298386014237	putative dimer interface [polypeptide binding]; other site
298386014238	C-terminal, alpha helical domain of an unknown subfamily 5 of Glutathione S-transferases; Region: GST_C_5; cd03196
298386014239	putative N-terminal domain interface [polypeptide binding]; other site
298386014240	putative dimer interface [polypeptide binding]; other site
298386014241	putative substrate binding pocket (H-site) [chemical binding]; other site
298386014242	Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements.  They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801
298386014243	active site
298386014244	Int/Topo IB signature motif; other site
298386014245	Phage-related protein, tail component [Function unknown]; Region: COG4733
298386014246	Putative phage tail protein; Region: Phage-tail_3; pfam13550
298386014247	Domain of unknown function (DUF1833); Region: DUF1833; pfam08875
298386014248	Phage-related minor tail protein [Function unknown]; Region: COG5281
298386014249	Prophage tail length tape measure protein; Region: TMP_2; pfam06791
298386014250	Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718
298386014251	Phage related hypothetical protein (DUF1799); Region: DUF1799; pfam08809
298386014252	Domain of unknown function (DUF1789); Region: DUF1789; pfam08748
298386014253	Phage tail protein; Region: Phage_tail_3; pfam08813
298386014254	bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072
298386014255	Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521
298386014256	Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054
298386014257	oligomerization interface [polypeptide binding]; other site
298386014258	phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554
298386014259	Phage capsid family; Region: Phage_capsid; pfam05065
298386014260	Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016
298386014261	oligomer interface [polypeptide binding]; other site
298386014262	active site residues [active]
298386014263	Phage-related protein [Function unknown]; Region: COG4695; cl01923
298386014264	Phage portal protein; Region: Phage_portal; pfam04860
298386014265	Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626
298386014266	Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403
298386014267	HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085
298386014268	active site
298386014269	Protein of unknown function (DUF2384); Region: DUF2384; pfam09722
298386014270	RES domain; Region: RES; pfam08808
298386014271	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
298386014272	Uncharacterized protein family (UPF0157); Region: UPF0157; cl00987
298386014273	Transposase IS200 like; Region: Y1_Tnp; pfam01797
298386014274	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386014275	The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417
298386014276	substrate binding pocket [chemical binding]; other site
298386014277	dimerization interface [polypeptide binding]; other site
298386014278	N-acetylmuramoyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: AmiC; COG0860
298386014279	N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696
298386014280	active site
298386014281	metal binding site [ion binding]; metal-binding site
298386014282	YcxB-like protein; Region: YcxB; pfam14317
298386014283	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
298386014284	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386014285	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298386014286	binding surface
298386014287	Tetratricopeptide repeat; Region: TPR_12; pfam13424
298386014288	TPR motif; other site
298386014289	Restriction endonuclease; Region: Mrr_cat; pfam04471
298386014290	Protein of unknown function (DUF2743); Region: DUF2743; pfam10899
298386014291	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
298386014292	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
298386014293	Walker A motif; other site
298386014294	ATP binding site [chemical binding]; other site
298386014295	Walker B motif; other site
298386014296	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298386014297	non-specific DNA binding site [nucleotide binding]; other site
298386014298	salt bridge; other site
298386014299	sequence-specific DNA binding site [nucleotide binding]; other site
298386014300	Aminomethyltransferase folate-binding domain; Region: GCV_T; pfam01571
298386014301	Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669
298386014302	Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115
298386014303	Sodium:alanine symporter family; Region: Na_Ala_symp; cl00548
298386014304	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298386014305	non-specific DNA binding site [nucleotide binding]; other site
298386014306	salt bridge; other site
298386014307	sequence-specific DNA binding site [nucleotide binding]; other site
298386014308	Cupin domain; Region: Cupin_2; pfam07883
298386014309	serine hydroxymethyltransferase; Reviewed; Region: PRK13034
298386014310	Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378
298386014311	dimer interface [polypeptide binding]; other site
298386014312	active site
298386014313	glycine-pyridoxal phosphate binding site [chemical binding]; other site
298386014314	folate binding site [chemical binding]; other site
298386014315	Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848
298386014316	lipoyl attachment site [posttranslational modification]; other site
298386014317	glycine dehydrogenase; Provisional; Region: PRK05367
298386014318	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
298386014319	tetramer interface [polypeptide binding]; other site
298386014320	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298386014321	catalytic residue [active]
298386014322	Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613
298386014323	tetramer interface [polypeptide binding]; other site
298386014324	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298386014325	catalytic residue [active]
298386014326	Protein of unknown function (DUF535); Region: DUF535; pfam04393
298386014327	PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130
298386014328	PAS domain; Region: PAS_9; pfam13426
298386014329	putative active site [active]
298386014330	heme pocket [chemical binding]; other site
298386014331	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
298386014332	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
298386014333	dimer interface [polypeptide binding]; other site
298386014334	putative CheW interface [polypeptide binding]; other site
298386014335	glycogen branching enzyme; Provisional; Region: PRK05402
298386014336	Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101
298386014337	N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855
298386014338	Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322
298386014339	active site
298386014340	catalytic site [active]
298386014341	Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806
298386014342	4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052
298386014343	4-alpha-glucanotransferase [Carbohydrate transport and metabolism]; Region: MalQ; COG1640
298386014344	This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300
298386014345	homodimer interface [polypeptide binding]; other site
298386014346	glycogen/starch/alpha-glucan phosphorylases; Region: P_ylase; TIGR02093
298386014347	active site pocket [active]
298386014348	transcriptional regulator MalT; Provisional; Region: PRK04841
298386014349	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298386014350	DNA binding residues [nucleotide binding]
298386014351	dimerization interface [polypeptide binding]; other site
298386014352	Domain of unknown function (DUF4336); Region: DUF4336; pfam14234
298386014353	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
298386014354	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
298386014355	homoserine O-acetyltransferase; Provisional; Region: metX; cl17114
298386014356	Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697
298386014357	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
298386014358	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
298386014359	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
298386014360	Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612
298386014361	Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675
298386014362	Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193
298386014363	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386014364	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386014365	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
298386014366	dimerization interface [polypeptide binding]; other site
298386014367	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
298386014368	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
298386014369	HlyD family secretion protein; Region: HlyD_3; pfam13437
298386014370	Protein of unknown function (DUF2955); Region: DUF2955; pfam11168
298386014371	Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394
298386014372	transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283
298386014373	active site
298386014374	Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586
298386014375	SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335
298386014376	LssY C-terminus; Region: LssY_C; pfam14067
298386014377	Uncharacterized protein with SCP/PR1 domains [Function unknown]; Region: COG2340
298386014378	SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379
298386014379	Protein of unknown function (DUF1800); Region: DUF1800; pfam08811
298386014380	Protein of unknown function (DUF1501); Region: DUF1501; pfam07394
298386014381	molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144
298386014382	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298386014383	Walker A/P-loop; other site
298386014384	ATP binding site [chemical binding]; other site
298386014385	Q-loop/lid; other site
298386014386	ABC transporter signature motif; other site
298386014387	Walker B; other site
298386014388	D-loop; other site
298386014389	H-loop/switch region; other site
298386014390	molybdenum-pterin binding domain; Region: Mop; TIGR00638
298386014391	ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555
298386014392	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386014393	dimer interface [polypeptide binding]; other site
298386014394	conserved gate region; other site
298386014395	putative PBP binding loops; other site
298386014396	ABC-ATPase subunit interface; other site
298386014397	molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677
298386014398	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199
298386014399	cell density-dependent motility repressor; Provisional; Region: PRK10082
298386014400	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386014401	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
298386014402	dimerization interface [polypeptide binding]; other site
298386014403	Sodium:dicarboxylate symporter family; Region: SDF; pfam00375
298386014404	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
298386014405	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386014406	malate dehydrogenase; Provisional; Region: PRK13529
298386014407	Malic enzyme, N-terminal domain; Region: malic; pfam00390
298386014408	NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312
298386014409	NAD(P) binding site [chemical binding]; other site
298386014410	putative manganese-dependent inorganic pyrophosphatase; Provisional; Region: PRK05427
298386014411	DHH family; Region: DHH; pfam01368
298386014412	DHHA2 domain; Region: DHHA2; pfam02833
298386014413	Peptidase M14-like domain; uncharacterized subfamily; Region: M14-like_4; cd06231
298386014414	putative active site [active]
298386014415	Zn binding site [ion binding]; other site
298386014416	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386014417	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
298386014418	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386014419	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386014420	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
298386014421	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
298386014422	FMN binding site [chemical binding]; other site
298386014423	active site
298386014424	substrate binding site [chemical binding]; other site
298386014425	catalytic residue [active]
298386014426	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298386014427	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298386014428	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298386014429	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298386014430	Cytochrome b (N-terminus)/b6/petB:  Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859
298386014431	formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583
298386014432	tetrathionate reductase subunit A; Provisional; Region: PRK14991
298386014433	The MopB_Tetrathionate-Ra CD contains tetrathionate reductase, subunit A, (TtrA) and other related proteins. The Salmonella enterica tetrathionate reductase catalyses the reduction of trithionate but not sulfur or thiosulfate. Members of this CD belong...; Region: MopB_Tetrathionate-Ra; cd02758
298386014434	putative [Fe4-S4] binding site [ion binding]; other site
298386014435	putative molybdopterin cofactor binding site [chemical binding]; other site
298386014436	This CD contains the molybdopterin_binding C-terminal (MopB_CT) region of tetrathionate reductase, subunit A, (TtrA); respiratory arsenate As(V) reductase, catalytic subunit (ArrA); and other related proteins; Region: MopB_CT_Tetrathionate_Arsenate-R; cd02780
298386014437	putative molybdopterin cofactor binding site; other site
298386014438	lipoate-protein ligase A; Provisional; Region: lplA; PRK03822
298386014439	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
298386014440	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
298386014441	nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484
298386014442	Na binding site [ion binding]; other site
298386014443	putative substrate binding site [chemical binding]; other site
298386014444	cytosine deaminase; Provisional; Region: PRK09230
298386014445	Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293
298386014446	active site
298386014447	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cd00190
298386014448	cleavage site
298386014449	active site
298386014450	substrate binding sites [chemical binding]; other site
298386014451	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
298386014452	Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816
298386014453	Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320
298386014454	active site
298386014455	purine riboside binding site [chemical binding]; other site
298386014456	Protein of unknown function (DUF2975); Region: DUF2975; pfam11188
298386014457	Predicted transcriptional regulator [Transcription]; Region: COG3655
298386014458	salt bridge; other site
298386014459	non-specific DNA binding site [nucleotide binding]; other site
298386014460	sequence-specific DNA binding site [nucleotide binding]; other site
298386014461	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386014462	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
298386014463	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
298386014464	Walker A/P-loop; other site
298386014465	ATP binding site [chemical binding]; other site
298386014466	Q-loop/lid; other site
298386014467	ABC transporter signature motif; other site
298386014468	Walker B; other site
298386014469	D-loop; other site
298386014470	H-loop/switch region; other site
298386014471	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462
298386014472	4Fe-4S binding domain; Region: Fer4_5; pfam12801
298386014473	4Fe-4S binding domain; Region: Fer4_5; pfam12801
298386014474	4Fe-4S dicluster domain; Region: Fer4_7; pfam12838
298386014475	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
298386014476	Winged helix-turn helix; Region: HTH_29; pfam13551
298386014477	Homeodomain-like domain; Region: HTH_32; pfam13565
298386014478	Integrase core domain; Region: rve; pfam00665
298386014479	Integrase core domain; Region: rve_3; pfam13683
298386014480	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
298386014481	Transposase; Region: HTH_Tnp_1; cl17663
298386014482	Transposase; Region: HTH_Tnp_1; cl17663
298386014483	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; pfam12762
298386014484	RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651
298386014485	Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078
298386014486	putative active site [active]
298386014487	putative NTP binding site [chemical binding]; other site
298386014488	putative nucleic acid binding site [nucleotide binding]; other site
298386014489	Group II intron, maturase-specific domain; Region: GIIM; pfam08388
298386014490	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
298386014491	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
298386014492	active site
298386014493	DNA binding site [nucleotide binding]
298386014494	Int/Topo IB signature motif; other site
298386014495	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
298386014496	Putative transposase; Region: Y2_Tnp; pfam04986
298386014497	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880
298386014498	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
298386014499	GTP-binding protein HflX; Region: GTP_HflX; TIGR03156
298386014500	GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167
298386014501	HflX GTPase family; Region: HflX; cd01878
298386014502	G1 box; other site
298386014503	GTP/Mg2+ binding site [chemical binding]; other site
298386014504	Switch I region; other site
298386014505	G2 box; other site
298386014506	G3 box; other site
298386014507	Switch II region; other site
298386014508	G4 box; other site
298386014509	G5 box; other site
298386014510	PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria.  Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443
298386014511	CoenzymeA binding site [chemical binding]; other site
298386014512	subunit interaction site [polypeptide binding]; other site
298386014513	PHB binding site; other site
298386014514	Predicted DNA-binding proteins [General function prediction only]; Region: COG1342
298386014515	ABC transporter, permease/ATP-binding protein; Region: MsbA_rel; TIGR02204
298386014516	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
298386014517	ATP-binding cassette domain of a mitochondrial protein MTABC3 and related proteins; Region: ABC_MTABC3_MDL1_MDL2; cd03249
298386014518	Walker A/P-loop; other site
298386014519	ATP binding site [chemical binding]; other site
298386014520	Q-loop/lid; other site
298386014521	ABC transporter signature motif; other site
298386014522	Walker B; other site
298386014523	D-loop; other site
298386014524	H-loop/switch region; other site
298386014525	Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236
298386014526	Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753
298386014527	Beta-Casp domain; Region: Beta-Casp; smart01027
298386014528	RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521
298386014529	D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine  to pyruvate and ammonia.  D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447
298386014530	Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291
298386014531	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
298386014532	catalytic residue [active]
298386014533	fructuronate transporter; Provisional; Region: PRK10034; cl15264
298386014534	Homeodomain-like domain; Region: HTH_23; pfam13384
298386014535	Winged helix-turn helix; Region: HTH_29; pfam13551
298386014536	Winged helix-turn helix; Region: HTH_33; pfam13592
298386014537	DDE superfamily endonuclease; Region: DDE_3; pfam13358
298386014538	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
298386014539	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
298386014540	dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606
298386014541	Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995
298386014542	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
298386014543	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day.  Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803
298386014544	active site
298386014545	FMN binding site [chemical binding]; other site
298386014546	substrate binding site [chemical binding]; other site
298386014547	putative catalytic residue [active]
298386014548	Protein of unknown function (DUF465); Region: DUF465; pfam04325
298386014549	O-acetylhomoserine aminocarboxypropyltransferase; Validated; Region: PRK06084
298386014550	CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614
298386014551	homodimer interface [polypeptide binding]; other site
298386014552	substrate-cofactor binding pocket; other site
298386014553	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298386014554	catalytic residue [active]
298386014555	N(5)-(carboxyethyl)ornithine synthase; Region: ceo_syn; cd12181
298386014556	putative active site [active]
298386014557	putative ligand binding site [chemical binding]; other site
298386014558	Alanine dehydrogenase/PNT, C-terminal domain; Region: AlaDh_PNT_C; pfam01262
298386014559	putative NAD(P) binding site [chemical binding]; other site
298386014560	NH_hydro_CaPnhB: A subgroup of nucleoside hydrolases similar to Corynebacterium ammoniagenes Purine/pyrimidine nucleoside hydrolase (pnhB). Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These...; Region: nuc_hydro_CaPnhB; cd02650
298386014561	active site
298386014562	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386014563	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386014564	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
298386014565	dimerization interface [polypeptide binding]; other site
298386014566	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
298386014567	Bacterial Transmembrane Pair family; Region: BTP; pfam05232
298386014568	Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272
298386014569	Formimidoylglutamase or HutE; Region: Formimidoylglutamase; cd09988
298386014570	putative active site [active]
298386014571	putative metal binding site [ion binding]; other site
298386014572	Transcriptional regulator [Transcription]; Region: IclR; COG1414
298386014573	Bacterial transcriptional regulator; Region: IclR; pfam01614
298386014574	Transposase IS200 like; Region: Y1_Tnp; pfam01797
298386014575	Uncharacterized conserved protein [Function unknown]; Region: COG4628
298386014576	Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849
298386014577	MarR family; Region: MarR_2; pfam12802
298386014578	helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347
298386014579	Protein of unknown function (DUF2955); Region: DUF2955; pfam11168
298386014580	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
298386014581	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
298386014582	HlyD family secretion protein; Region: HlyD_3; pfam13437
298386014583	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386014584	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386014585	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
298386014586	dimerization interface [polypeptide binding]; other site
298386014587	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386014588	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386014589	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
298386014590	dimerization interface [polypeptide binding]; other site
298386014591	putative monooxygenase; Provisional; Region: PRK11118
298386014592	Protein of unknown function (DUF917); Region: DUF917; cl17829
298386014593	VRR-NUC domain; Region: VRR_NUC; pfam08774
298386014594	DnaB-like helicase N terminal domain; Region: DnaB; pfam00772
298386014595	AAA domain; Region: AAA_25; pfam13481
298386014596	Hexameric Replicative Helicase RepA.  RepA is encoded by a plasmid, which is found in most Gram negative bacteria. RepA is a 5'-3' DNA helicase which can utilize ATP, GTP and CTP to a lesser extent; Region: repA; cd01125
298386014597	Walker A motif; other site
298386014598	NTP binding site [chemical binding]; other site
298386014599	hexamer interface [polypeptide binding]; other site
298386014600	Walker B motif; other site
298386014601	PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684
298386014602	SH3 domain protein; Region: SH3_and_anchor; TIGR04211
298386014603	AAA domain; Region: AAA_24; pfam13479
298386014604	Transposase IS200 like; Region: Y1_Tnp; pfam01797
298386014605	Homeodomain-like domain; Region: HTH_23; pfam13384
298386014606	Winged helix-turn helix; Region: HTH_29; pfam13551
298386014607	Winged helix-turn helix; Region: HTH_33; pfam13592
298386014608	DDE superfamily endonuclease; Region: DDE_3; pfam13358
298386014609	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
298386014610	Transposase [DNA replication, recombination, and repair]; Region: COG5433
298386014611	Integrase core domain; Region: rve_3; pfam13683
298386014612	Winged helix-turn helix; Region: HTH_29; pfam13551
298386014613	Homeodomain-like domain; Region: HTH_32; pfam13565
298386014614	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
298386014615	Transposase; Region: HTH_Tnp_1; cl17663
298386014616	Transposase; Region: HTH_Tnp_1; cl17663
298386014617	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
298386014618	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
298386014619	Transposase [DNA replication, recombination, and repair]; Region: COG5433
298386014620	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386014621	Homeodomain-like domain; Region: HTH_23; pfam13384
298386014622	Winged helix-turn helix; Region: HTH_29; pfam13551
298386014623	Winged helix-turn helix; Region: HTH_33; pfam13592
298386014624	DDE superfamily endonuclease; Region: DDE_3; pfam13358
298386014625	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
298386014626	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386014627	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
298386014628	Transposase; Region: HTH_Tnp_1; cl17663
298386014629	Transposase; Region: HTH_Tnp_1; cl17663
298386014630	Winged helix-turn helix; Region: HTH_29; pfam13551
298386014631	Homeodomain-like domain; Region: HTH_32; pfam13565
298386014632	Integrase core domain; Region: rve; pfam00665
298386014633	Integrase core domain; Region: rve_3; pfam13683
298386014634	Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972
298386014635	Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773
298386014636	Nucleoside recognition; Region: Gate; pfam07670
298386014637	Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662
298386014638	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
298386014639	Domain of unknown function (DUF1768); Region: DUF1768; pfam08719
298386014640	GTP cyclohydrolase II (RibA).  GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641
298386014641	dimerization interface [polypeptide binding]; other site
298386014642	active site
298386014643	dUMP phosphatase; Provisional; Region: PRK09449
298386014644	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
298386014645	motif II; other site
298386014646	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
298386014647	Branched-chain amino acid transport protein; Region: Branch_AA_trans; cl00547
298386014648	putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005
298386014649	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
298386014650	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386014651	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
298386014652	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
298386014653	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
298386014654	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
298386014655	Transposase; Region: DEDD_Tnp_IS110; pfam01548
298386014656	ExoU and VipD-like proteins; homologus to patatin, cPLA2, and iPLA2; Region: Pat_ExoU_VipD_like; cd07207
298386014657	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752
298386014658	active site
298386014659	nucleophile elbow; other site
298386014660	Bacillus haemolytic enterotoxin (HBL); Region: Bacillus_HBL; pfam05791
298386014661	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
298386014662	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
298386014663	This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587
298386014664	active site
298386014665	N-formylglutamate amidohydrolase; Region: FGase; pfam05013
298386014666	conserved hypothetical protein; Region: QEGLA; TIGR02421
298386014667	Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951
298386014668	glutathione synthetase; Provisional; Region: PRK12458
298386014669	Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955
298386014670	Protein of unknown function, DUF; Region: DUF413; pfam04219
298386014671	transcriptional regulator HdfR; Provisional; Region: PRK03601
298386014672	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386014673	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
298386014674	dimerization interface [polypeptide binding]; other site
298386014675	IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717
298386014676	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
298386014677	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386014678	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
298386014679	IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817
298386014680	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
298386014681	Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452
298386014682	substrate binding site [chemical binding]; other site
298386014683	nucleotide binding site [chemical binding]; other site
298386014684	Homeodomain-like domain; Region: HTH_23; pfam13384
298386014685	Winged helix-turn helix; Region: HTH_29; pfam13551
298386014686	Winged helix-turn helix; Region: HTH_33; pfam13592
298386014687	DDE superfamily endonuclease; Region: DDE_3; pfam13358
298386014688	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
298386014689	ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141
298386014690	ACT domains located C-terminal to the catalytic domain of the aspartokinase of the ectoine (1,4,5,6-tetrahydro-2-methyl pyrimidine-4-carboxylate) biosynthetic pathway; Region: ACT_AK-Ectoine_2; cd04915
298386014691	Disulphide bond corrector protein DsbC; Region: DsbC; cl15830
298386014692	Thiol:disulfide interchange protein [Posttranslational modification, protein turnover, chaperones / Energy production and conversion]; Region: COG4232
298386014693	Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788
298386014694	DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953
298386014695	DsbD alpha interface [polypeptide binding]; other site
298386014696	catalytic residues [active]
298386014697	TlpA-like family, suppressor for copper sensitivity D protein (ScsD) and actinobacterial DsbE homolog subfamily; composed of ScsD, the DsbE homolog of Mycobacterium tuberculosis (MtbDsbE) and similar proteins, all containing a redox-active CXXC motif; Region: TlpA_like_ScsD_MtbDsbE; cd03011
298386014698	Thioredoxin-like; Region: Thioredoxin_8; pfam13905
298386014699	catalytic residues [active]
298386014700	YbaK-like.  The YbaK family of deacylase domains includes the INS amino acid-editing domain of  the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cd04332
298386014701	putative deacylase active site [active]
298386014702	NlpC/P60 family; Region: NLPC_P60; pfam00877
298386014703	Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673
298386014704	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298386014705	Coenzyme A binding pocket [chemical binding]; other site
298386014706	1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018
298386014707	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989
298386014708	putative acyl-acceptor binding pocket; other site
298386014709	Protein of unknown function (DUF2750); Region: DUF2750; pfam11042
298386014710	Methyltransferase domain; Region: Methyltransf_18; pfam12847
298386014711	Predicted permeases [General function prediction only]; Region: RarD; COG2962
298386014712	EamA-like transporter family; Region: EamA; pfam00892
298386014713	Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537
298386014714	homodimer interface [polypeptide binding]; other site
298386014715	chemical substrate binding site [chemical binding]; other site
298386014716	oligomer interface [polypeptide binding]; other site
298386014717	metal binding site [ion binding]; metal-binding site
298386014718	Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110
298386014719	redox-sensitive transcriptional activator SoxR; Region: SoxR; TIGR01950
298386014720	DNA binding residues [nucleotide binding]
298386014721	dimer interface [polypeptide binding]; other site
298386014722	[2Fe-2S] cluster binding site [ion binding]; other site
298386014723	H+ Antiporter protein; Region: 2A0121; TIGR00900
298386014724	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298386014725	putative substrate translocation pore; other site
298386014726	Predicted permease; Region: DUF318; cl17795
298386014727	Predicted permease; Region: DUF318; cl17795
298386014728	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414
298386014729	DNA-binding site [nucleotide binding]; DNA binding site
298386014730	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
298386014731	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
298386014732	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
298386014733	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
298386014734	DctM-like transporters; Region: DctM; pfam06808
298386014735	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
298386014736	Glucuronate isomerase; Region: UxaC; pfam02614
298386014737	Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904
298386014738	altronate oxidoreductase; Provisional; Region: PRK03643
298386014739	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
298386014740	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
298386014741	galactarate dehydratase; Region: galactar-dH20; TIGR03248
298386014742	Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613
298386014743	D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295
298386014744	RecX family; Region: RecX; pfam02631
298386014745	RecX family; Region: RecX; pfam02631
298386014746	Homeodomain-like domain; Region: HTH_23; pfam13384
298386014747	Winged helix-turn helix; Region: HTH_29; pfam13551
298386014748	Winged helix-turn helix; Region: HTH_33; pfam13592
298386014749	DDE superfamily endonuclease; Region: DDE_3; pfam13358
298386014750	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
298386014751	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386014752	Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314
298386014753	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
298386014754	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
298386014755	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298386014756	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298386014757	Protein of unknown function (DUF1329); Region: DUF1329; pfam07044
298386014758	Transposase IS200 like; Region: Y1_Tnp; pfam01797
298386014759	short chain dehydrogenase; Provisional; Region: PRK06172
298386014760	classical (c) SDRs; Region: SDR_c; cd05233
298386014761	NAD(P) binding site [chemical binding]; other site
298386014762	active site
298386014763	LytB protein; Region: LYTB; cl00507
298386014764	Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033
298386014765	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298386014766	Coenzyme A binding pocket [chemical binding]; other site
298386014767	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
298386014768	NADH(P)-binding; Region: NAD_binding_10; pfam13460
298386014769	NAD(P) binding site [chemical binding]; other site
298386014770	putative active site [active]
298386014771	selenocysteine-specific elongation factor SelB; Region: selB; TIGR00475
298386014772	Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170
298386014773	G2 box; other site
298386014774	Switch I region; other site
298386014775	G3 box; other site
298386014776	Switch II region; other site
298386014777	GTP/Mg2+ binding site [chemical binding]; other site
298386014778	G4 box; other site
298386014779	G5 box; other site
298386014780	selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696
298386014781	Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107
298386014782	seryl-tRNA(sec) selenium transferase; Region: selA; TIGR00474
298386014783	Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390
298386014784	Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321
298386014785	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
298386014786	catalytic residue [active]
298386014787	Glycine/sarcosine/betaine reductase selenoprotein B (GRDB); Region: GRDB; pfam07355
298386014788	glycine reductase, selenoprotein B; Region: gly_red_sel_B; TIGR01917
298386014789	Glycine/sarcosine/betaine reductase component B subunits; Region: Gly_reductase; pfam09338
298386014790	Selenophosphate synthetase  (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195
298386014791	dimerization interface [polypeptide binding]; other site
298386014792	putative ATP binding site [chemical binding]; other site
298386014793	Fatty acid synthesis protein; Region: FA_synthesis; cl17261
298386014794	"initiating" condensing enzymes are a subclass of decarboxylating condensing enzymes, including beta-ketoacyl [ACP] synthase, type III and polyketide synthases, type III, which include chalcone synthase and related enzymes. They are...; Region: init_cond_enzymes; cd00827
298386014795	dimer interface [polypeptide binding]; other site
298386014796	active site
298386014797	putative glycine/sarcosine/betaine reductase complex protein A; Provisional; Region: PRK14717
298386014798	putative glycine/sarcosine/betaine reductase complex protein A; Provisional; Region: PRK14717
298386014799	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
298386014800	catalytic residues [active]
298386014801	thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292
298386014802	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
298386014803	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
298386014804	Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388
298386014805	M18 Peptidase Aminopeptidase I; Region: M18_API; cd05659
298386014806	Aminopeptidase I zinc metalloprotease (M18); Region: Peptidase_M18; pfam02127
298386014807	oligomer interface [polypeptide binding]; other site
298386014808	putative active site [active]
298386014809	metal binding site [ion binding]; metal-binding site
298386014810	DsrE/DsrF-like family; Region: DrsE; cl00672
298386014811	DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676
298386014812	N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005
298386014813	TOBE domain; Region: TOBE; cl01440
298386014814	TOBE domain; Region: TOBE; cl01440
298386014815	D-ribose pyranase; Provisional; Region: PRK11797
298386014816	D-ribose transporter ATP binding protein; Provisional; Region: PRK10762
298386014817	First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216
298386014818	Walker A/P-loop; other site
298386014819	ATP binding site [chemical binding]; other site
298386014820	Q-loop/lid; other site
298386014821	ABC transporter signature motif; other site
298386014822	Walker B; other site
298386014823	D-loop; other site
298386014824	H-loop/switch region; other site
298386014825	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
298386014826	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
298386014827	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
298386014828	TM-ABC transporter signature motif; other site
298386014829	D-ribose transporter subunit RbsB; Provisional; Region: PRK10653
298386014830	Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323
298386014831	ligand binding site [chemical binding]; other site
298386014832	dimerization interface [polypeptide binding]; other site
298386014833	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
298386014834	Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174
298386014835	substrate binding site [chemical binding]; other site
298386014836	dimer interface [polypeptide binding]; other site
298386014837	ATP binding site [chemical binding]; other site
298386014838	transcriptional repressor RbsR; Provisional; Region: PRK10423
298386014839	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
298386014840	DNA binding site [nucleotide binding]
298386014841	domain linker motif; other site
298386014842	Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275
298386014843	dimerization interface [polypeptide binding]; other site
298386014844	ligand binding site [chemical binding]; other site
298386014845	Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931
298386014846	NAD(P) binding site [chemical binding]; other site
298386014847	active site
298386014848	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386014849	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386014850	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
298386014851	putative effector binding pocket; other site
298386014852	dimerization interface [polypeptide binding]; other site
298386014853	NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252
298386014854	NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500
298386014855	Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070
298386014856	Transposase IS200 like; Region: Y1_Tnp; pfam01797
298386014857	S-formylglutathione hydrolase; Region: PLN02442
298386014858	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386014859	S-formylglutathione hydrolase; Region: PLN02442
298386014860	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386014861	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386014862	The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like_1; cd08470
298386014863	putative effector binding pocket; other site
298386014864	putative dimerization interface [polypeptide binding]; other site
298386014865	glutathione-dependent formaldehyde-activating enzyme; Provisional; Region: PRK05417
298386014866	Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230
298386014867	S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I;  AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440
298386014868	S-adenosylmethionine binding site [chemical binding]; other site
298386014869	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
298386014870	Uncharacterized conserved protein [Function unknown]; Region: COG2128
298386014871	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386014872	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386014873	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
298386014874	putative effector binding pocket; other site
298386014875	dimerization interface [polypeptide binding]; other site
298386014876	hypothetical protein; Provisional; Region: PRK12378
298386014877	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298386014878	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298386014879	DNA binding residues [nucleotide binding]
298386014880	dimerization interface [polypeptide binding]; other site
298386014881	Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263
298386014882	PTS system, glucose-specific IIBC component; Region: PTS-II-BC-glcB; TIGR02002
298386014883	PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212
298386014884	active site turn [active]
298386014885	phosphorylation site [posttranslational modification]
298386014886	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
298386014887	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386014888	active site
298386014889	phosphorylation site [posttranslational modification]
298386014890	intermolecular recognition site; other site
298386014891	dimerization interface [polypeptide binding]; other site
298386014892	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298386014893	DNA binding site [nucleotide binding]
298386014894	HAMP domain; Region: HAMP; pfam00672
298386014895	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cl00080
298386014896	dimer interface [polypeptide binding]; other site
298386014897	phosphorylation site [posttranslational modification]
298386014898	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386014899	ATP binding site [chemical binding]; other site
298386014900	Mg2+ binding site [ion binding]; other site
298386014901	G-X-G motif; other site
298386014902	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
298386014903	Peptidase S8 family domain, uncharacterized subfamily 13; Region: Peptidases_S8_13; cd07496
298386014904	active site
298386014905	catalytic triad [active]
298386014906	Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215
298386014907	aromatic chitin/cellulose binding site residues [chemical binding]; other site
298386014908	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386014909	Protein of unknown function (DUF808); Region: DUF808; cl01002
298386014910	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298386014911	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298386014912	DNA binding residues [nucleotide binding]
298386014913	dimerization interface [polypeptide binding]; other site
298386014914	Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167
298386014915	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298386014916	DNA-binding site [nucleotide binding]; DNA binding site
298386014917	Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609
298386014918	pyridoxal 5'-phosphate binding site [chemical binding]; other site
298386014919	homodimer interface [polypeptide binding]; other site
298386014920	catalytic residue [active]
298386014921	D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711
298386014922	Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558
298386014923	DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086
298386014924	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386014925	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
298386014926	dimerization interface [polypeptide binding]; other site
298386014927	TrbC/VIRB2 family; Region: TrbC; cl01583
298386014928	Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501
298386014929	conjugal transfer protein TrbE; Provisional; Region: PRK13891
298386014930	CagE, TrbE, VirB family, component of type IV transporter system; Region: CagE_TrbE_VirB; pfam03135
298386014931	P-type conjugative transfer protein TrbJ; Region: TrbJ_Ti; TIGR02780
298386014932	P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782
298386014933	Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130
298386014934	ATP binding site [chemical binding]; other site
298386014935	Walker A motif; other site
298386014936	hexamer interface [polypeptide binding]; other site
298386014937	Walker B motif; other site
298386014938	P-type conjugative transfer protein TrbL; Region: TrbL_P; TIGR02783
298386014939	VirB8 protein; Region: VirB8; cl01500
298386014940	VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911
298386014941	VirB7 interaction site; other site
298386014942	conjugal transfer protein TrbH; Provisional; Region: PRK13883
298386014943	YedD-like protein; Region: YedD; cl08117
298386014944	Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242
298386014945	pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519
298386014946	Bacterial type II and III secretion system protein; Region: Secretin; pfam00263
298386014947	Type II/IV secretion system protein; Region: T2SE; pfam00437
298386014948	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
298386014949	Walker A motif; other site
298386014950	ATP binding site [chemical binding]; other site
298386014951	Walker B motif; other site
298386014952	Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165
298386014953	prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532
298386014954	Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149
298386014955	conjugative transfer signal peptidase TraF; Region: TraF_Ti; TIGR02771
298386014956	The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530
298386014957	Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741
298386014958	Lytic Transglycosylase (LT)  and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL).  LTs...; Region: LT_GEWL; cd00254
298386014959	N-acetyl-D-glucosamine binding site [chemical binding]; other site
298386014960	Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534
298386014961	RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233
298386014962	Walker A motif; other site
298386014963	ATP binding site [chemical binding]; other site
298386014964	Walker B motif; other site
298386014965	conjugal transfer relaxase TraI; Provisional; Region: PRK13878
298386014966	Relaxase/Mobilisation nuclease domain; Region: Relaxase; pfam03432
298386014967	Protein of unknown function (DUF1778); Region: DUF1778; cl01845
298386014968	conjugal transfer protein TraL; Provisional; Region: PRK13886
298386014969	coenzyme A disulfide reductase; Provisional; Region: PRK13512
298386014970	Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227
298386014971	Domain of unknown function (DUF1738); Region: DUF1738; pfam08401
298386014972	putative oxidoreductase; Provisional; Region: PRK11579
298386014973	hypothetical protein; Provisional; Region: PRK02487
298386014974	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
298386014975	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
298386014976	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
298386014977	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
298386014978	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386014979	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386014980	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
298386014981	putative effector binding pocket; other site
298386014982	dimerization interface [polypeptide binding]; other site
298386014983	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
298386014984	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
298386014985	HlyD family secretion protein; Region: HlyD_3; pfam13437
298386014986	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
298386014987	Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203
298386014988	Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342
298386014989	trimer interface [polypeptide binding]; other site
298386014990	eyelet of channel; other site
298386014991	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547
298386014992	Transposase; Region: DEDD_Tnp_IS110; pfam01548
298386014993	Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371
298386014994	AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719
298386014995	HD domain; Region: HD_3; pfam13023
298386014996	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
298386014997	putative DNA binding site [nucleotide binding]; other site
298386014998	putative Zn2+ binding site [ion binding]; other site
298386014999	Aldehyde dehydrogenase family; Region: Aldedh; pfam00171
298386015000	NAD(P)+ dependent aldehyde dehydrogenase family; Region: ALDH; cd07078
298386015001	NAD(P) binding site [chemical binding]; other site
298386015002	catalytic residues [active]
298386015003	2OG-Fe(II) oxygenase superfamily; Region: 2OG-FeII_Oxy_3; cl17304
298386015004	Elongator protein 3, MiaB family, Radical SAM; Region: Elp3; smart00729
298386015005	Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335
298386015006	FeS/SAM binding site; other site
298386015007	Putative threonine efflux protein [Amino acid transport and metabolism]; Region: RhtB; COG1280
298386015008	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386015009	The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414
298386015010	dimerization interface [polypeptide binding]; other site
298386015011	substrate binding pocket [chemical binding]; other site
298386015012	DDE domain; Region: DDE_Tnp_IS240; pfam13610
298386015013	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
298386015014	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
298386015015	FMN binding site [chemical binding]; other site
298386015016	active site
298386015017	substrate binding site [chemical binding]; other site
298386015018	catalytic residue [active]
298386015019	NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902
298386015020	Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933
298386015021	FMN binding site [chemical binding]; other site
298386015022	active site
298386015023	substrate binding site [chemical binding]; other site
298386015024	catalytic residue [active]
298386015025	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386015026	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386015027	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
298386015028	dimerization interface [polypeptide binding]; other site
298386015029	DDE domain; Region: DDE_Tnp_IS240; pfam13610
298386015030	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
298386015031	Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302
298386015032	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
298386015033	Integrase core domain; Region: rve; pfam00665
298386015034	Predicted transcriptional regulators [Transcription]; Region: COG1733
298386015035	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
298386015036	dimerization interface [polypeptide binding]; other site
298386015037	putative DNA binding site [nucleotide binding]; other site
298386015038	putative Zn2+ binding site [ion binding]; other site
298386015039	Uncharacterized conserved protein [Function unknown]; Region: COG2128
298386015040	Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627
298386015041	Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249
298386015042	Protein of unknown function (DUF3316); Region: DUF3316; pfam11777
298386015043	Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738
298386015044	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
298386015045	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386015046	Integrase core domain; Region: rve; pfam00665
298386015047	Uncharacterized conserved protein [Function unknown]; Region: COG1359
298386015048	Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737
298386015049	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
298386015050	Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284
298386015051	catalytic motif [active]
298386015052	Zn binding site [ion binding]; other site
298386015053	Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876
298386015054	short chain dehydrogenase; Provisional; Region: PRK06138
298386015055	classical (c) SDRs; Region: SDR_c; cd05233
298386015056	NAD(P) binding site [chemical binding]; other site
298386015057	active site
298386015058	Domain of unknown function (DUF336); Region: DUF336; pfam03928
298386015059	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
298386015060	Transcriptional regulator [Transcription]; Region: IclR; COG1414
298386015061	Bacterial transcriptional regulator; Region: IclR; pfam01614
298386015062	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298386015063	non-specific DNA binding site [nucleotide binding]; other site
298386015064	salt bridge; other site
298386015065	sequence-specific DNA binding site [nucleotide binding]; other site
298386015066	integrase; Provisional; Region: int; PHA02601
298386015067	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
298386015068	active site
298386015069	DNA binding site [nucleotide binding]
298386015070	Int/Topo IB signature motif; other site
298386015071	Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475
298386015072	Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999
298386015073	Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841
298386015074	Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456
298386015075	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
298386015076	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
298386015077	HlyD family secretion protein; Region: HlyD_3; pfam13437
298386015078	RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730
298386015079	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
298386015080	HlyD family secretion protein; Region: HlyD_3; pfam13437
298386015081	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
298386015082	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
298386015083	HlyD family secretion protein; Region: HlyD_3; pfam13437
298386015084	Arabinose-binding domain of AraC transcription regulator, N-term; Region: Arabinose_bd; pfam12625
298386015085	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
298386015086	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298386015087	universal stress protein UspE; Provisional; Region: PRK11175
298386015088	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
298386015089	Ligand Binding Site [chemical binding]; other site
298386015090	Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293
298386015091	Ligand Binding Site [chemical binding]; other site
298386015092	BCCT family transporter; Region: BCCT; pfam02028
298386015093	Nuclease-related domain; Region: NERD; pfam08378
298386015094	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
298386015095	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386015096	SEC-C motif; Region: SEC-C; pfam02810
298386015097	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
298386015098	tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225
298386015099	DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213
298386015100	active site
298386015101	DNA binding site [nucleotide binding]
298386015102	Int/Topo IB signature motif; other site
298386015103	Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319
298386015104	Putative transposase; Region: Y2_Tnp; pfam04986
298386015105	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386015106	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
298386015107	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
298386015108	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298386015109	Coenzyme A binding pocket [chemical binding]; other site
298386015110	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
298386015111	Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; pfam05708
298386015112	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386015113	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
298386015114	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386015115	Integrase core domain; Region: rve_3; pfam13683
298386015116	Winged helix-turn helix; Region: HTH_29; pfam13551
298386015117	Homeodomain-like domain; Region: HTH_32; pfam13565
298386015118	Integrase core domain; Region: rve; pfam00665
298386015119	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963
298386015120	Transposase; Region: HTH_Tnp_1; cl17663
298386015121	Transposase; Region: HTH_Tnp_1; cl17663
298386015122	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
298386015123	Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124
298386015124	Cytochrome P450; Region: p450; cl12078
298386015125	TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722
298386015126	guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096
298386015127	IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381
298386015128	active site
298386015129	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386015130	Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823
298386015131	Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u1; cd11477
298386015132	Na binding site [ion binding]; other site
298386015133	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677
298386015134	ISXO2-like transposase domain; Region: DDE_Tnp_IS1595; cl01481
298386015135	Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629
298386015136	Transcriptional regulator [Transcription]; Region: IclR; COG1414
298386015137	IclR helix-turn-helix domain; Region: HTH_IclR; cl17605
298386015138	Bacterial transcriptional regulator; Region: IclR; pfam01614
298386015139	DctM-like transporters; Region: DctM; pfam06808
298386015140	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
298386015141	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
298386015142	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
298386015143	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
298386015144	5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924
298386015145	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
298386015146	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
298386015147	active site
298386015148	intersubunit interface [polypeptide binding]; other site
298386015149	catalytic residue [active]
298386015150	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
298386015151	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
298386015152	substrate binding site [chemical binding]; other site
298386015153	ATP binding site [chemical binding]; other site
298386015154	hypothetical protein; Provisional; Region: PRK09273
298386015155	Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698
298386015156	Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408
298386015157	Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917
298386015158	Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688
298386015159	2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993
298386015160	gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347
298386015161	NADP binding site [chemical binding]; other site
298386015162	homodimer interface [polypeptide binding]; other site
298386015163	active site
298386015164	DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090
298386015165	helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346
298386015166	Bacterial transcriptional regulator; Region: IclR; pfam01614
298386015167	Predicted signal-transduction protein containing cAMP-binding and CBS domains [Signal transduction mechanisms]; Region: COG2905
298386015168	effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038
298386015169	ligand binding site [chemical binding]; other site
298386015170	flexible hinge region; other site
298386015171	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with either the CAP_ED (cAMP receptor protein effector domain) family of transcription factors and the DUF294 domain or the PB1 (Phox and Bem1p) domain; Region: CBS_pair_CAP-ED_DUF294_PBI_assoc; cd04587
298386015172	Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401
298386015173	metal binding triad; other site
298386015174	DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847
298386015175	DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127
298386015176	active site
298386015177	catalytic site [active]
298386015178	substrate binding site [chemical binding]; other site
298386015179	Choline/Carnitine o-acyltransferase; Region: Carn_acyltransf; pfam00755
298386015180	choline ABC transporter, ATP-binding protein; Region: ABC_choXWV_ATP; TIGR03415
298386015181	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298386015182	Walker A/P-loop; other site
298386015183	ATP binding site [chemical binding]; other site
298386015184	Q-loop/lid; other site
298386015185	ABC transporter signature motif; other site
298386015186	Walker B; other site
298386015187	D-loop; other site
298386015188	H-loop/switch region; other site
298386015189	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386015190	dimer interface [polypeptide binding]; other site
298386015191	conserved gate region; other site
298386015192	putative PBP binding loops; other site
298386015193	ABC-ATPase subunit interface; other site
298386015194	choline ABC transporter, periplasmic binding protein; Region: ABC_choline_bnd; TIGR03414
298386015195	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
298386015196	choline dehydrogenase; Validated; Region: PRK02106
298386015197	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
298386015198	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
298386015199	NAD(P) binding site [chemical binding]; other site
298386015200	catalytic residues [active]
298386015201	transcriptional regulator BetI; Validated; Region: PRK00767
298386015202	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298386015203	Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977
298386015204	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298386015205	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298386015206	dimer interface [polypeptide binding]; other site
298386015207	phosphorylation site [posttranslational modification]
298386015208	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386015209	ATP binding site [chemical binding]; other site
298386015210	Mg2+ binding site [ion binding]; other site
298386015211	G-X-G motif; other site
298386015212	Response regulator receiver domain; Region: Response_reg; pfam00072
298386015213	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386015214	active site
298386015215	phosphorylation site [posttranslational modification]
298386015216	intermolecular recognition site; other site
298386015217	dimerization interface [polypeptide binding]; other site
298386015218	hypothetical protein; Provisional; Region: PRK07179
298386015219	Aminotransferase class I and II; Region: Aminotran_1_2; pfam00155
298386015220	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
298386015221	catalytic residue [active]
298386015222	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
298386015223	dimerization interface [polypeptide binding]; other site
298386015224	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
298386015225	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
298386015226	dimer interface [polypeptide binding]; other site
298386015227	putative CheW interface [polypeptide binding]; other site
298386015228	Transposase IS200 like; Region: Y1_Tnp; pfam01797
298386015229	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386015230	type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843
298386015231	Peptidase family M23; Region: Peptidase_M23; pfam01551
298386015232	HlyD family secretion protein; Region: HlyD_3; pfam13437
298386015233	Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642
298386015234	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386015235	Response regulator receiver domain; Region: Response_reg; pfam00072
298386015236	active site
298386015237	phosphorylation site [posttranslational modification]
298386015238	intermolecular recognition site; other site
298386015239	dimerization interface [polypeptide binding]; other site
298386015240	type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844
298386015241	type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842
298386015242	AAA domain; Region: AAA_25; pfam13481
298386015243	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298386015244	Walker A/P-loop; other site
298386015245	ATP binding site [chemical binding]; other site
298386015246	Q-loop/lid; other site
298386015247	type I secretion system ABC transporter, PrtD family; Region: type_I_sec_PrtD; TIGR01842
298386015248	ABC transporter transmembrane region; Region: ABC_membrane; pfam00664
298386015249	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298386015250	Walker A/P-loop; other site
298386015251	ATP binding site [chemical binding]; other site
298386015252	Q-loop/lid; other site
298386015253	ABC transporter signature motif; other site
298386015254	Walker B; other site
298386015255	D-loop; other site
298386015256	H-loop/switch region; other site
298386015257	DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker  B motif; Region: DEADc; cd00268
298386015258	ATP binding site [chemical binding]; other site
298386015259	Mg++ binding site [ion binding]; other site
298386015260	motif III; other site
298386015261	Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079
298386015262	nucleotide binding region [chemical binding]; other site
298386015263	ATP-binding site [chemical binding]; other site
298386015264	Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; pfam09907
298386015265	Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093
298386015266	non-specific DNA binding site [nucleotide binding]; other site
298386015267	salt bridge; other site
298386015268	sequence-specific DNA binding site [nucleotide binding]; other site
298386015269	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
298386015270	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386015271	Integrase core domain; Region: rve; pfam00665
298386015272	Replicase family; Region: Replicase; pfam03090
298386015273	Primase C terminal 1 (PriCT-1); Region: PriCT_1; cl07362
298386015274	ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533
298386015275	Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793
298386015276	The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709
298386015277	thioredoxin 2; Provisional; Region: PRK10996
298386015278	TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947
298386015279	catalytic residues [active]
298386015280	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
298386015281	homotrimer interaction site [polypeptide binding]; other site
298386015282	putative active site [active]
298386015283	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
298386015284	homotrimer interaction site [polypeptide binding]; other site
298386015285	putative active site [active]
298386015286	YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448
298386015287	homotrimer interaction site [polypeptide binding]; other site
298386015288	putative active site [active]
298386015289	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298386015290	Acetyltransferases [General function prediction only]; Region: RimI; COG0456
298386015291	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182
298386015292	Coenzyme A binding pocket [chemical binding]; other site
298386015293	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
298386015294	ChrR Cupin-like domain; Region: Cupin_7; pfam12973
298386015295	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386015296	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
298386015297	The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432
298386015298	dimerization interface [polypeptide binding]; other site
298386015299	substrate binding pocket [chemical binding]; other site
298386015300	Protein of unknown function (DUF3429); Region: DUF3429; pfam11911
298386015301	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
298386015302	DNA-binding site [nucleotide binding]; DNA binding site
298386015303	RNA-binding motif; other site
298386015304	Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281
298386015305	Homeodomain-like domain; Region: HTH_23; pfam13384
298386015306	Winged helix-turn helix; Region: HTH_29; pfam13551
298386015307	Winged helix-turn helix; Region: HTH_33; pfam13592
298386015308	DDE superfamily endonuclease; Region: DDE_3; pfam13358
298386015309	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
298386015310	Transposase IS200 like; Region: Y1_Tnp; pfam01797
298386015311	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
298386015312	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
298386015313	putative substrate binding site [chemical binding]; other site
298386015314	nucleotide binding site [chemical binding]; other site
298386015315	nucleotide binding site [chemical binding]; other site
298386015316	homodimer interface [polypeptide binding]; other site
298386015317	Adenylosuccinate synthetase; Region: Adenylsucc_synt; pfam00709
298386015318	Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788
298386015319	The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203
298386015320	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386015321	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386015322	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
298386015323	dimerization interface [polypeptide binding]; other site
298386015324	ABC-type proline/glycine betaine transport system, ATPase component [Amino acid transport and metabolism]; Region: ProV; COG4175
298386015325	ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294
298386015326	Walker A/P-loop; other site
298386015327	ATP binding site [chemical binding]; other site
298386015328	Q-loop/lid; other site
298386015329	ABC transporter signature motif; other site
298386015330	Walker B; other site
298386015331	D-loop; other site
298386015332	H-loop/switch region; other site
298386015333	This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583
298386015334	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386015335	dimer interface [polypeptide binding]; other site
298386015336	conserved gate region; other site
298386015337	putative PBP binding loops; other site
298386015338	ABC-ATPase subunit interface; other site
298386015339	ABC-type proline/glycine betaine transport systems, periplasmic components [Amino acid transport and metabolism]; Region: ProX; COG2113
298386015340	Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069
298386015341	sugar phosphate phosphatase; Provisional; Region: PRK10513
298386015342	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
298386015343	active site
298386015344	motif I; other site
298386015345	motif II; other site
298386015346	Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427
298386015347	Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566
298386015348	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
298386015349	HlyD family secretion protein; Region: HlyD_3; pfam13437
298386015350	Protein of unknown function (DUF2955); Region: DUF2955; pfam11168
298386015351	4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297
298386015352	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
298386015353	FMN-binding domain; Region: FMN_bind; pfam04205
298386015354	4Fe-4S binding domain; Region: Fer4_5; pfam12801
298386015355	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386015356	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386015357	Homeodomain-like domain; Region: HTH_23; pfam13384
298386015358	Winged helix-turn helix; Region: HTH_29; pfam13551
298386015359	Winged helix-turn helix; Region: HTH_33; pfam13592
298386015360	DDE superfamily endonuclease; Region: DDE_3; pfam13358
298386015361	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
298386015362	DDE superfamily endonuclease; Region: DDE_3; pfam13358
298386015363	Bacterial OB fold (BOF) protein; Region: BOF; cl01196
298386015364	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386015365	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
298386015366	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
298386015367	dimerization interface [polypeptide binding]; other site
298386015368	Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688
298386015369	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
298386015370	Fasciclin domain; Region: Fasciclin; pfam02469
298386015371	Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335
298386015372	Fasciclin domain; Region: Fasciclin; pfam02469
298386015373	Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095
298386015374	Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437
298386015375	Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053
298386015376	cation diffusion facilitator family transporter; Region: CDF; TIGR01297
298386015377	Methyladenine glycosylase; Region: Adenine_glyco; cl01059
298386015378	Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375
298386015379	Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193
298386015380	FAD binding pocket [chemical binding]; other site
298386015381	FAD binding motif [chemical binding]; other site
298386015382	phosphate binding motif [ion binding]; other site
298386015383	NAD binding pocket [chemical binding]; other site
298386015384	phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12822
298386015385	DAHP synthetase I family; Region: DAHP_synth_1; pfam00793
298386015386	ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120
298386015387	ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214
298386015388	Walker A/P-loop; other site
298386015389	ATP binding site [chemical binding]; other site
298386015390	Q-loop/lid; other site
298386015391	ABC transporter signature motif; other site
298386015392	Walker B; other site
298386015393	D-loop; other site
298386015394	H-loop/switch region; other site
298386015395	ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779
298386015396	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
298386015397	ABC-ATPase subunit  interface; other site
298386015398	dimer interface [polypeptide binding]; other site
298386015399	putative PBP binding regions; other site
298386015400	iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577
298386015401	Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550
298386015402	ABC-ATPase subunit  interface; other site
298386015403	dimer interface [polypeptide binding]; other site
298386015404	putative PBP binding regions; other site
298386015405	ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614
298386015406	Fe3+-siderophore binding domain FhuD.  These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146
298386015407	siderophore binding site; other site
298386015408	Adenylate forming domain, Class I; Region: AFD_class_I; cl17068
298386015409	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
298386015410	acyl-activating enzyme (AAE) consensus motif; other site
298386015411	AMP binding site [chemical binding]; other site
298386015412	active site
298386015413	CoA binding site [chemical binding]; other site
298386015414	Condensation domain; Region: Condensation; pfam00668
298386015415	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
298386015416	HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745
298386015417	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
298386015418	acyl-activating enzyme (AAE) consensus motif; other site
298386015419	AMP binding site [chemical binding]; other site
298386015420	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
298386015421	Condensation domain; Region: Condensation; pfam00668
298386015422	non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261
298386015423	Condensation domain; Region: Condensation; pfam00668
298386015424	Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020
298386015425	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
298386015426	2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220
298386015427	2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331
298386015428	putative NAD(P) binding site [chemical binding]; other site
298386015429	active site
298386015430	Condensation domain; Region: Condensation; pfam00668
298386015431	The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930
298386015432	amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733
298386015433	acyl-activating enzyme (AAE) consensus motif; other site
298386015434	AMP binding site [chemical binding]; other site
298386015435	Phosphopantetheine attachment site; Region: PP-binding; pfam00550
298386015436	Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013
298386015437	hydrophobic substrate binding pocket; other site
298386015438	Isochorismatase family; Region: Isochorismatase; pfam00857
298386015439	active site
298386015440	conserved cis-peptide bond; other site
298386015441	Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433
298386015442	enterobactin synthase subunit E; Provisional; Region: entE; PRK10946
298386015443	2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920
298386015444	acyl-activating enzyme (AAE) consensus motif; other site
298386015445	active site
298386015446	AMP binding site [chemical binding]; other site
298386015447	substrate binding site [chemical binding]; other site
298386015448	Isochorismate synthase [Coenzyme metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: MenF; COG1169
298386015449	chorismate binding enzyme; Region: Chorismate_bind; cl10555
298386015450	Outer membrane receptor for ferrienterochelin and colicins [Inorganic ion transport and metabolism]; Region: FepA; COG4771
298386015451	TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347
298386015452	N-terminal plug; other site
298386015453	ligand-binding site [chemical binding]; other site
298386015454	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298386015455	putative substrate translocation pore; other site
298386015456	Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814
298386015457	Phosphopantetheinyl transferase component of siderophore synthetase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntD; COG2977
298386015458	4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648
298386015459	Winged helix-turn helix; Region: HTH_29; pfam13551
298386015460	Homeodomain-like domain; Region: HTH_23; pfam13384
298386015461	Homeodomain-like domain; Region: HTH_32; pfam13565
298386015462	Winged helix-turn helix; Region: HTH_33; pfam13592
298386015463	DDE superfamily endonuclease; Region: DDE_3; pfam13358
298386015464	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335
298386015465	poly(R)-hydroxyalkanoic acid synthase, class I; Region: PHA_synth_I; TIGR01838
298386015466	Poly-beta-hydroxybutyrate polymerase (PhaC) N-terminus; Region: PhaC_N; pfam07167
298386015467	phasin family protein; Region: phasin_3; TIGR02809
298386015468	Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751
298386015469	acetyl-CoA acetyltransferases; Region: AcCoA-C-Actrans; TIGR01930
298386015470	dimer interface [polypeptide binding]; other site
298386015471	active site
298386015472	acetoacetyl-CoA reductase; Provisional; Region: PRK12824
298386015473	beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333
298386015474	NAD(P) binding site [chemical binding]; other site
298386015475	homotetramer interface [polypeptide binding]; other site
298386015476	homodimer interface [polypeptide binding]; other site
298386015477	active site
298386015478	MoxR-like ATPases [General function prediction only]; Region: COG0714
298386015479	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298386015480	Walker A motif; other site
298386015481	ATP binding site [chemical binding]; other site
298386015482	Walker B motif; other site
298386015483	arginine finger; other site
298386015484	Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721
298386015485	Protein of unknown function DUF58; Region: DUF58; pfam01882
298386015486	Domain of unknown function (DUF4381); Region: DUF4381; pfam14316
298386015487	Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304
298386015488	VWA BatA type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_BatA_type; cd01467
298386015489	metal ion-dependent adhesion site (MIDAS); other site
298386015490	Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198
298386015491	metal ion-dependent adhesion site (MIDAS); other site
298386015492	Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189
298386015493	TPR motif; other site
298386015494	binding surface
298386015495	Tetratricopeptide repeat; Region: TPR_16; pfam13432
298386015496	Oxygen tolerance; Region: BatD; pfam13584
298386015497	serine/threonine transporter SstT; Provisional; Region: PRK13628
298386015498	Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301
298386015499	Protein of unknown function (DUF1611); Region: DUF1611; pfam07755
298386015500	Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457
298386015501	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase-like 1; Region: PLPDE_III_AR_like_1; cd06815
298386015502	dimer interface [polypeptide binding]; other site
298386015503	active site
298386015504	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
298386015505	substrate binding site [chemical binding]; other site
298386015506	catalytic residue [active]
298386015507	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386015508	Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520
298386015509	cysteine desulfurase family protein, VC1184 subfamily; Region: am_tr_V_VC1184; TIGR01976
298386015510	pyridoxal 5'-phosphate binding pocket [chemical binding]; other site
298386015511	catalytic residue [active]
298386015512	Biofilm formation and stress response factor; Region: BsmA; cl01794
298386015513	ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG0390
298386015514	putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247
298386015515	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298386015516	Walker A/P-loop; other site
298386015517	ATP binding site [chemical binding]; other site
298386015518	ABC transporter signature motif; other site
298386015519	Walker B; other site
298386015520	D-loop; other site
298386015521	H-loop/switch region; other site
298386015522	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
298386015523	DNA-binding site [nucleotide binding]; DNA binding site
298386015524	RNA-binding motif; other site
298386015525	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386015526	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386015527	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
298386015528	putative effector binding pocket; other site
298386015529	dimerization interface [polypeptide binding]; other site
298386015530	efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845
298386015531	multidrug efflux system protein EmrA; Provisional; Region: PRK15136
298386015532	Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533
298386015533	HlyD family secretion protein; Region: HlyD_3; pfam13437
298386015534	drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711
298386015535	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298386015536	putative substrate translocation pore; other site
298386015537	atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243
298386015538	NADH(P)-binding; Region: NAD_binding_10; pfam13460
298386015539	NAD(P) binding site [chemical binding]; other site
298386015540	putative active site [active]
298386015541	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298386015542	Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104
298386015543	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
298386015544	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
298386015545	dimer interface [polypeptide binding]; other site
298386015546	putative CheW interface [polypeptide binding]; other site
298386015547	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
298386015548	HAMP (Histidine kinases, Adenylyl cyclases, Methyl binding proteins, Phosphatases) domain; Region: HAMP; smart00304
298386015549	dimerization interface [polypeptide binding]; other site
298386015550	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
298386015551	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
298386015552	dimer interface [polypeptide binding]; other site
298386015553	putative CheW interface [polypeptide binding]; other site
298386015554	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298386015555	dimerization interface [polypeptide binding]; other site
298386015556	Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283
298386015557	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
298386015558	dimer interface [polypeptide binding]; other site
298386015559	putative CheW interface [polypeptide binding]; other site
298386015560	Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653
298386015561	Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579
298386015562	TM-ABC transporter signature motif; other site
298386015563	galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982
298386015564	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298386015565	Walker A/P-loop; other site
298386015566	ATP binding site [chemical binding]; other site
298386015567	Q-loop/lid; other site
298386015568	ABC transporter signature motif; other site
298386015569	Walker B; other site
298386015570	D-loop; other site
298386015571	H-loop/switch region; other site
298386015572	Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215
298386015573	methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395
298386015574	Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539
298386015575	ligand binding site [chemical binding]; other site
298386015576	calcium binding site [ion binding]; other site
298386015577	Brown fat-inducible thioesterase (BFIT).  Brain acyl-CoA hydrolase (BACH).  These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442
298386015578	mannonate dehydratase; Provisional; Region: PRK03906
298386015579	mannonate dehydratase; Region: uxuA; TIGR00695
298386015580	Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377
298386015581	DNA-binding site [nucleotide binding]; DNA binding site
298386015582	This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895
298386015583	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
298386015584	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441
298386015585	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
298386015586	DctM-like transporters; Region: DctM; pfam06808
298386015587	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
298386015588	D-mannonate oxidoreductase; Provisional; Region: PRK15037
298386015589	Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232
298386015590	Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125
298386015591	Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524
298386015592	2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166
298386015593	substrate binding site [chemical binding]; other site
298386015594	ATP binding site [chemical binding]; other site
298386015595	keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718
298386015596	KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452
298386015597	active site
298386015598	intersubunit interface [polypeptide binding]; other site
298386015599	catalytic residue [active]
298386015600	Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688
298386015601	Domain of unknown function (DUF386); Region: DUF386; cl01047
298386015602	DctM-like transporters; Region: DctM; pfam06808
298386015603	TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593
298386015604	TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090
298386015605	TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638
298386015606	Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480
298386015607	LysE type translocator; Region: LysE; cl00565
298386015608	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
298386015609	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386015610	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
298386015611	dimerization interface [polypeptide binding]; other site
298386015612	NAD pyrophosphatase/5'-nucleotidase NadN; Region: nadN; TIGR01530
298386015613	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
298386015614	active site
298386015615	metal binding site [ion binding]; metal-binding site
298386015616	5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872
298386015617	Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505
298386015618	Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663
298386015619	Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215
298386015620	HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684
298386015621	FAD binding pocket [chemical binding]; other site
298386015622	FAD binding motif [chemical binding]; other site
298386015623	phosphate binding motif [ion binding]; other site
298386015624	beta-alpha-beta structure motif; other site
298386015625	NAD binding pocket [chemical binding]; other site
298386015626	2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207
298386015627	catalytic loop [active]
298386015628	iron binding site [ion binding]; other site
298386015629	hybrid cluster protein; Provisional; Region: PRK05290
298386015630	The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655
298386015631	ACS interaction site; other site
298386015632	CODH interaction site; other site
298386015633	Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914
298386015634	hybrid metal cluster; other site
298386015635	anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022
298386015636	GAF domain; Region: GAF; pfam01590
298386015637	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298386015638	Walker A motif; other site
298386015639	ATP binding site [chemical binding]; other site
298386015640	Walker B motif; other site
298386015641	arginine finger; other site
298386015642	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386015643	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386015644	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
298386015645	putative effector binding pocket; other site
298386015646	dimerization interface [polypeptide binding]; other site
298386015647	Protein of unknown function (DUF3179); Region: DUF3179; pfam11376
298386015648	DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139
298386015649	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386015650	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398
298386015651	dimerization interface [polypeptide binding]; other site
298386015652	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
298386015653	EamA-like transporter family; Region: EamA; pfam00892
298386015654	Predicted thiol oxidoreductase [Energy production and conversion]; Region: COG3488
298386015655	Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370
298386015656	Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879
298386015657	G1 box; other site
298386015658	GTP/Mg2+ binding site [chemical binding]; other site
298386015659	Switch I region; other site
298386015660	G2 box; other site
298386015661	G3 box; other site
298386015662	Switch II region; other site
298386015663	G4 box; other site
298386015664	G5 box; other site
298386015665	Nucleoside recognition; Region: Gate; pfam07670
298386015666	Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664
298386015667	FeoA domain; Region: FeoA; pfam04023
298386015668	ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653
298386015669	Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547
298386015670	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298386015671	dimerization interface [polypeptide binding]; other site
298386015672	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298386015673	dimer interface [polypeptide binding]; other site
298386015674	phosphorylation site [posttranslational modification]
298386015675	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386015676	ATP binding site [chemical binding]; other site
298386015677	Mg2+ binding site [ion binding]; other site
298386015678	G-X-G motif; other site
298386015679	Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745
298386015680	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386015681	active site
298386015682	phosphorylation site [posttranslational modification]
298386015683	intermolecular recognition site; other site
298386015684	dimerization interface [polypeptide binding]; other site
298386015685	Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383
298386015686	DNA binding site [nucleotide binding]
298386015687	RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY,  is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552
298386015688	30S subunit binding site; other site
298386015689	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
298386015690	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
298386015691	putative DNA binding site [nucleotide binding]; other site
298386015692	putative Zn2+ binding site [ion binding]; other site
298386015693	AsnC family; Region: AsnC_trans_reg; pfam01037
298386015694	Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697
298386015695	5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694
298386015696	Histidine kinase; Region: His_kinase; pfam06580
298386015697	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386015698	ATP binding site [chemical binding]; other site
298386015699	Mg2+ binding site [ion binding]; other site
298386015700	G-X-G motif; other site
298386015701	Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279
298386015702	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386015703	active site
298386015704	phosphorylation site [posttranslational modification]
298386015705	intermolecular recognition site; other site
298386015706	dimerization interface [polypeptide binding]; other site
298386015707	LytTr DNA-binding domain; Region: LytTR; pfam04397
298386015708	oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890
298386015709	The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174
298386015710	putative substrate translocation pore; other site
298386015711	Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113
298386015712	putative glutamate/gamma-aminobutyrate antiporter; Region: put_Glu_GABA_T; TIGR03813
298386015713	AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235
298386015714	carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454
298386015715	putative substrate binding site [chemical binding]; other site
298386015716	nucleotide binding site [chemical binding]; other site
298386015717	nucleotide binding site [chemical binding]; other site
298386015718	homodimer interface [polypeptide binding]; other site
298386015719	Transcriptional regulator [Transcription]; Region: AcrR; COG1309
298386015720	Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440
298386015721	putrescine carbamoyltransferase; Provisional; Region: PRK02255
298386015722	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
298386015723	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
298386015724	NlpE N-terminal domain; Region: NlpE; pfam04170
298386015725	ornithine carbamoyltransferase; Validated; Region: PRK02102
298386015726	Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729
298386015727	Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185
298386015728	SGNH_hydrolase subfamily, FeeA, FeeB and similar esterases/lipases. FeeA and FeeB are part of a biosynthetic gene cluster and may participate in the biosynthesis of long-chain N-acyltyrosines by providing saturated and unsaturated fatty acids, which it...; Region: FeeA_FeeB_like; cd01836
298386015729	active site
298386015730	catalytic triad [active]
298386015731	oxyanion hole [active]
298386015732	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316
298386015733	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386015734	Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea.  CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458
298386015735	DNA-binding site [nucleotide binding]; DNA binding site
298386015736	RNA-binding motif; other site
298386015737	Uncharacterized conserved protein (DUF2196); Region: DUF2196; pfam09962
298386015738	lysophospholipase L2; Provisional; Region: PRK10749
298386015739	Putative lysophospholipase; Region: Hydrolase_4; pfam12146
298386015740	Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667
298386015741	Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208
298386015742	active site
298386015743	nucleophile elbow; other site
298386015744	This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function.  The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150
298386015745	homotrimer interaction site [polypeptide binding]; other site
298386015746	putative active site [active]
298386015747	Cytochrome c553 [Energy production and conversion]; Region: COG2863
298386015748	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298386015749	Coenzyme A binding pocket [chemical binding]; other site
298386015750	metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995
298386015751	metal binding site [ion binding]; metal-binding site
298386015752	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
298386015753	Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389
298386015754	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386015755	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386015756	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386015757	The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466
298386015758	dimerization interface [polypeptide binding]; other site
298386015759	multidrug efflux pump VmrA; Reviewed; Region: vmrA; PRK09575
298386015760	Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Streptococcus aureus MepA; Region: MATE_MepA_like; cd13143
298386015761	Aerolysin/Pertussis toxin (APT) domain; Region: APT; pfam03440
298386015762	Aerolysin toxin; Region: Aerolysin; pfam01117
298386015763	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
298386015764	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
298386015765	Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600
298386015766	DNA binding residues [nucleotide binding]
298386015767	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298386015768	TMAO reductase sytem sensor TorS; Region: TMAO_torS; TIGR02956
298386015769	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386015770	ATP binding site [chemical binding]; other site
298386015771	Mg2+ binding site [ion binding]; other site
298386015772	G-X-G motif; other site
298386015773	Response regulator receiver domain; Region: Response_reg; pfam00072
298386015774	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386015775	active site
298386015776	phosphorylation site [posttranslational modification]
298386015777	intermolecular recognition site; other site
298386015778	dimerization interface [polypeptide binding]; other site
298386015779	ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201
298386015780	Q-loop/lid; other site
298386015781	Walker B; other site
298386015782	D-loop; other site
298386015783	H-loop/switch region; other site
298386015784	phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097
298386015785	Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261
298386015786	dimer interface [polypeptide binding]; other site
298386015787	conserved gate region; other site
298386015788	ABC-ATPase subunit interface; other site
298386015789	putative FAD-binding dehydrogenase; Reviewed; Region: PRK12834
298386015790	Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303
298386015791	GMC oxidoreductase; Region: GMC_oxred_C; pfam05199
298386015792	Propeptide_C25; Region: Propeptide_C25; pfam08126
298386015793	gingipain subgroup of the Peptidase C25 family N-terminal domain; Region: Peptidase_C25_N_gingipain; cd10913
298386015794	active site
298386015795	Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729
298386015796	Methyl-accepting chemotaxis protein [Cell motility and secretion / Signal transduction mechanisms]; Region: Tar; COG0840
298386015797	Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225
298386015798	dimerization interface [polypeptide binding]; other site
298386015799	Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386
298386015800	dimer interface [polypeptide binding]; other site
298386015801	putative CheW interface [polypeptide binding]; other site
298386015802	alanine racemase; Reviewed; Region: PRK13340
298386015803	Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme, Alanine Racemase 2; Region: PLPDE_III_AR2; cd06826
298386015804	active site
298386015805	pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site
298386015806	dimer interface [polypeptide binding]; other site
298386015807	substrate binding site [chemical binding]; other site
298386015808	catalytic residues [active]
298386015809	Transcriptional regulators [Transcription]; Region: Lrp; COG1522
298386015810	Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090
298386015811	putative DNA binding site [nucleotide binding]; other site
298386015812	putative Zn2+ binding site [ion binding]; other site
298386015813	AsnC family; Region: AsnC_trans_reg; pfam01037
298386015814	Protein of unknown function (DUF461); Region: DUF461; pfam04314
298386015815	Predicted permeases [General function prediction only]; Region: COG0679
298386015816	RNA recognition motif; Region: RRM; smart00360
298386015817	Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075
298386015818	lipase chaperone; Provisional; Region: PRK01294
298386015819	Proteobacterial lipase chaperone protein; Region: Lipase_chap; pfam03280
298386015820	AraC-like ligand binding domain; Region: AraC_binding; pfam02311
298386015821	Cystatin-like domain; Cystatins are a family of cysteine protease inhibitors that occur mainly as single domain proteins. However some extracellular proteins such as kininogen, His-rich glycoprotein and fetuin also contain these domains; Region: CY; cd00042
298386015822	putative proteinase inhibition site; other site
298386015823	DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808
298386015824	Transposase DDE domain; Region: DDE_Tnp_1; pfam01609
298386015825	Transposase [DNA replication, recombination, and repair]; Region: COG5433
298386015826	Transposase [DNA replication, recombination, and repair]; Region: COG5433
298386015827	PAP2_like_5 proteins. PAP2 is a super-family of phosphatases and haloperoxidases. This subgroup, which is specific to bacteria, lacks functional characterization and may act as a membrane-associated lipid phosphatase; Region: PAP2_like_5; cd03394
298386015828	Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671
298386015829	active site
298386015830	Beta-lactamase; Region: Beta-lactamase; pfam00144
298386015831	Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680
298386015832	YadA-like C-terminal region; Region: YadA; pfam03895
298386015833	Winged helix DNA-binding domain; Region: HTH_27; pfam13463
298386015834	Flavodoxin-like fold; Region: Flavodoxin_2; cl00438
298386015835	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
298386015836	flagellar biosynthesis regulator FlhF; Provisional; Region: flhF; PRK14723
298386015837	fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310
298386015838	putative fimbrial protein TcfA; Provisional; Region: PRK15308
298386015839	CS1 type fimbrial major subunit; Region: Fimbrial_CS1; cl04524
298386015840	DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019
298386015841	catalytic residues [active]
298386015842	hinge region; other site
298386015843	alpha helical domain; other site
298386015844	Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436
298386015845	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386015846	Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110
298386015847	Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647
298386015848	trimer interface [polypeptide binding]; other site
298386015849	active site
298386015850	substrate binding site [chemical binding]; other site
298386015851	CoA binding site [chemical binding]; other site
298386015852	Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279
298386015853	Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984
298386015854	putative acyl-acceptor binding pocket; other site
298386015855	Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485
298386015856	Surface antigen; Region: Bac_surface_Ag; pfam01103
298386015857	Protein of unknown function (DUF3283); Region: DUF3283; pfam11686
298386015858	CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739
298386015859	CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673
298386015860	CRISPR-associated helicase Cas3; Region: cas3_core; TIGR01587
298386015861	DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251
298386015862	CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cl00656
298386015863	Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050
298386015864	Predicted symporter [General function prediction only]; Region: DhlC; COG4147
298386015865	Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475
298386015866	Na binding site [ion binding]; other site
298386015867	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
298386015868	NAD(P) binding site [chemical binding]; other site
298386015869	catalytic residues [active]
298386015870	NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961
298386015871	bifunctional proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: PRK11904
298386015872	Proline dehydrogenase; Region: Pro_dh; pfam01619
298386015873	Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125
298386015874	Glutamate binding site [chemical binding]; other site
298386015875	NAD binding site [chemical binding]; other site
298386015876	catalytic residues [active]
298386015877	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298386015878	helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342
298386015879	Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165
298386015880	Predicted permeases [General function prediction only]; Region: COG0679
298386015881	Transcriptional regulators [Transcription]; Region: PurR; COG1609
298386015882	Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392
298386015883	DNA binding site [nucleotide binding]
298386015884	domain linker motif; other site
298386015885	Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267
298386015886	ligand binding site [chemical binding]; other site
298386015887	dimerization interface [polypeptide binding]; other site
298386015888	Porin superfamily.  These outer membrane channels share a beta-barrel structure that differ in strand and shear number.  Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244
298386015889	PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215
298386015890	methionine cluster; other site
298386015891	active site
298386015892	phosphorylation site [posttranslational modification]
298386015893	metal binding site [ion binding]; metal-binding site
298386015894	Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723
298386015895	beta-galactosidase; Region: BGL; TIGR03356
298386015896	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
298386015897	cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592
298386015898	PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564
298386015899	active site
298386015900	P-loop; other site
298386015901	phosphorylation site [posttranslational modification]
298386015902	Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455
298386015903	Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378
298386015904	Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326
298386015905	Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534
298386015906	Predicted flavoprotein [General function prediction only]; Region: COG0431
298386015907	NADPH-dependent FMN reductase; Region: FMN_red; pfam03358
298386015908	Transcriptional regulator [Transcription]; Region: LysR; COG0583
298386015909	Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126
298386015910	The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422
298386015911	putative effector binding pocket; other site
298386015912	dimerization interface [polypeptide binding]; other site
298386015913	Protein of unknown function (DUF2899); Region: DUF2899; pfam11449
298386015914	PAS fold; Region: PAS_4; pfam08448
298386015915	Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197
298386015916	C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170
298386015917	DNA binding residues [nucleotide binding]
298386015918	dimerization interface [polypeptide binding]; other site
298386015919	pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679
298386015920	Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243
298386015921	Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590
298386015922	Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191
298386015923	Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082
298386015924	dimer interface [polypeptide binding]; other site
298386015925	phosphorylation site [posttranslational modification]
298386015926	Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075
298386015927	ATP binding site [chemical binding]; other site
298386015928	Mg2+ binding site [ion binding]; other site
298386015929	G-X-G motif; other site
298386015930	Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204
298386015931	Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156
298386015932	active site
298386015933	phosphorylation site [posttranslational modification]
298386015934	intermolecular recognition site; other site
298386015935	dimerization interface [polypeptide binding]; other site
298386015936	The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009
298386015937	Walker A motif; other site
298386015938	ATP binding site [chemical binding]; other site
298386015939	Walker B motif; other site
298386015940	arginine finger; other site
298386015941	Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954
298386015942	c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal    transduction mechanisms]; Region: COG2199
298386015943	Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949
298386015944	metal binding site [ion binding]; metal-binding site
298386015945	active site
298386015946	I-site; other site
298386015947	EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2).  The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948
298386015948	Protein of unknown function (DUF342); Region: DUF342; pfam03961
298386015949	putative hydrolase; Validated; Region: PRK09248
298386015950	Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437
298386015951	active site
298386015952	Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444
298386015953	Domain of unknown function (DUF1726); Region: DUF1726; pfam08351
298386015954	Helicase; Region: Helicase_RecD; pfam05127
298386015955	N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301
298386015956	Coenzyme A binding pocket [chemical binding]; other site
298386015957	Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725
298386015958	plasmid-partitioning protein; Provisional; Region: PRK13698
298386015959	ParB-like nuclease domain; Region: ParBc; pfam02195
298386015960	ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192
298386015961	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
298386015962	P-loop; other site
298386015963	Magnesium ion binding site [ion binding]; other site
298386015964	ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042
298386015965	Magnesium ion binding site [ion binding]; other site