-- dump date 20140619_234056 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1142394000001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1142394000002 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1142394000003 Walker A motif; other site 1142394000004 ATP binding site [chemical binding]; other site 1142394000005 Walker B motif; other site 1142394000006 arginine finger; other site 1142394000007 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1142394000008 DnaA box-binding interface [nucleotide binding]; other site 1142394000009 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1142394000010 FtsX-like permease family; Region: FtsX; pfam02687 1142394000011 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1142394000012 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1142394000013 Walker A/P-loop; other site 1142394000014 ATP binding site [chemical binding]; other site 1142394000015 Q-loop/lid; other site 1142394000016 ABC transporter signature motif; other site 1142394000017 Walker B; other site 1142394000018 D-loop; other site 1142394000019 H-loop/switch region; other site 1142394000020 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1142394000021 S-adenosylmethionine binding site [chemical binding]; other site 1142394000022 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 1142394000023 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1142394000024 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 1142394000025 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1142394000026 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4641 1142394000027 Glycosyl transferases group 1; Region: Glyco_trans_1_2; pfam13524 1142394000028 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1142394000029 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1142394000030 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1142394000031 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1142394000032 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1142394000033 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1142394000034 NAD(P) binding site [chemical binding]; other site 1142394000035 active site 1142394000036 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1142394000037 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1142394000038 NAD(P) binding site [chemical binding]; other site 1142394000039 active site 1142394000040 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1142394000041 UbiA prenyltransferase family; Region: UbiA; pfam01040 1142394000042 3-polyprenyl-4-hydroxybenzoate decarboxylase [Coenzyme metabolism]; Region: UbiX; COG0163 1142394000043 Flavoprotein; Region: Flavoprotein; pfam02441 1142394000044 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01096 1142394000045 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1142394000046 Zn2+ binding site [ion binding]; other site 1142394000047 Mg2+ binding site [ion binding]; other site 1142394000048 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1142394000049 DNA-binding site [nucleotide binding]; DNA binding site 1142394000050 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1142394000051 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1142394000052 ligand binding site [chemical binding]; other site 1142394000053 dimerization interface [polypeptide binding]; other site 1142394000054 Fascin-like domain; members include actin-bundling/crosslinking proteins facsin, histoactophilin and singed; identified in sea urchin, Drosophila, Xenopus, rodents, and humans; The fascin-like domain adopts a beta-trefoil topology and contains an...; Region: Fascin; cl00187 1142394000055 PKC phosphorylation site [posttranslational modification]; other site 1142394000056 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1142394000057 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1142394000058 Pyrimidine (PYR) binding domain of the beta subunits of the E1 components of human pyruvate dehydrogenase complex (E1- PDHc) and related proteins; Region: TPP_PYR_E1-PDHc-beta_like; cd07036 1142394000059 alpha subunit interface [polypeptide binding]; other site 1142394000060 TPP binding site [chemical binding]; other site 1142394000061 heterodimer interface [polypeptide binding]; other site 1142394000062 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1142394000063 YcfA-like protein; Region: YcfA; pfam07927 1142394000064 pyruvate dehydrogenase E1 component, alpha subunit; Region: PDH_E1_alph_y; TIGR03182 1142394000065 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1142394000066 tetramer interface [polypeptide binding]; other site 1142394000067 TPP-binding site [chemical binding]; other site 1142394000068 heterodimer interface [polypeptide binding]; other site 1142394000069 phosphorylation loop region [posttranslational modification] 1142394000070 methionine sulfoxide reductase A; Provisional; Region: PRK14054 1142394000071 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1142394000072 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1142394000073 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 1142394000074 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 1142394000075 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1142394000076 metal ion-dependent adhesion site (MIDAS); other site 1142394000077 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1142394000078 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1142394000079 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1142394000080 catalytic residue [active] 1142394000081 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1142394000082 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1142394000083 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1142394000084 transcription antitermination factor NusB; Region: nusB; TIGR01951 1142394000085 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 1142394000086 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 1142394000087 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 1142394000088 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 1142394000089 GTP cyclohydrolase II; Region: GTP_cyclohydro2; pfam00925 1142394000090 dimerization interface [polypeptide binding]; other site 1142394000091 active site 1142394000092 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cl15257 1142394000093 GIY-YIG motif/motif A; other site 1142394000094 active site 1142394000095 catalytic site [active] 1142394000096 metal binding site [ion binding]; metal-binding site 1142394000097 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 1142394000098 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1142394000099 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 1142394000100 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1142394000101 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1142394000102 putative active site [active] 1142394000103 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1142394000104 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1142394000105 active site 1142394000106 metal binding site [ion binding]; metal-binding site 1142394000107 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1142394000108 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_8; cd12167 1142394000109 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1142394000110 putative ligand binding site [chemical binding]; other site 1142394000111 putative NAD binding site [chemical binding]; other site 1142394000112 catalytic site [active] 1142394000113 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1142394000114 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1142394000115 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 1142394000116 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1142394000117 Domain of unknown function (DUF4394); Region: DUF4394; pfam14339 1142394000118 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1142394000119 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 1142394000120 O-Antigen ligase; Region: Wzy_C; cl04850 1142394000121 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1142394000122 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1142394000123 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 1142394000124 Predicted membrane protein involved in D-alanine export [Cell envelope biogenesis, outer membrane]; Region: DltB; COG1696 1142394000125 putative acyl transferase; Provisional; Region: PRK10502 1142394000126 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 1142394000127 putative trimer interface [polypeptide binding]; other site 1142394000128 putative active site [active] 1142394000129 putative substrate binding site [chemical binding]; other site 1142394000130 putative CoA binding site [chemical binding]; other site 1142394000131 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1142394000132 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1142394000133 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1142394000134 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 1142394000135 putative trimer interface [polypeptide binding]; other site 1142394000136 putative active site [active] 1142394000137 putative substrate binding site [chemical binding]; other site 1142394000138 putative CoA binding site [chemical binding]; other site 1142394000139 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1142394000140 putative metal binding site; other site 1142394000141 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1142394000142 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1142394000143 putative metal binding site; other site 1142394000144 PIN domain of ribonucleases (toxins), VapC, FitB, and PAE0151 of bacterial and archaeal toxin/antitoxin-like operons, and other similar homologs; Region: PIN_VapC-like; cd09861 1142394000145 putative active site [active] 1142394000146 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1142394000147 Methyltransferase domain; Region: Methyltransf_11; pfam08241 1142394000148 potential frameshift: common BLAST hit: gi|310825500|ref|YP_003957858.1| filamentation induced by camp protein fic 1142394000149 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 1142394000150 phosphoribose diphosphate:decaprenyl-phosphate phosphoribosyltransferase; Provisional; Region: PRK12324 1142394000151 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1142394000152 ligand-binding site [chemical binding]; other site 1142394000153 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 1142394000154 Vitamin K epoxide reductase (VKOR) family; Region: VKOR; cd10546 1142394000155 putative active site [active] 1142394000156 redox center [active] 1142394000157 hypothetical protein; Validated; Region: PRK00110 1142394000158 tRNA methyl transferase; Region: tRNA_Me_trans; pfam03054 1142394000159 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1142394000160 Ligand Binding Site [chemical binding]; other site 1142394000161 KaiB-like family; composed of the circadian clock proteins, KaiB and the N-terminal KaiB-like sensory domain of SasA. KaiB is an essential protein in maintaining circadian rhythm. It was originally discovered from the cyanobacterium Synechococcus as part...; Region: KaiB_like; cd02978 1142394000162 tetramer interface [polypeptide binding]; other site 1142394000163 dimer interface [polypeptide binding]; other site 1142394000164 circadian clock protein KaiC; Reviewed; Region: PRK09302 1142394000165 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1142394000166 Walker A motif; other site 1142394000167 Walker A motif; other site 1142394000168 ATP binding site [chemical binding]; other site 1142394000169 Walker B motif; other site 1142394000170 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1142394000171 ATP binding site [chemical binding]; other site 1142394000172 Walker B motif; other site 1142394000173 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1142394000174 PAS domain; Region: PAS_9; pfam13426 1142394000175 putative active site [active] 1142394000176 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1142394000177 ATP binding site [chemical binding]; other site 1142394000178 Mg2+ binding site [ion binding]; other site 1142394000179 G-X-G motif; other site 1142394000180 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1142394000181 NAD(P) binding site [chemical binding]; other site 1142394000182 catalytic residues [active] 1142394000183 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1142394000184 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1142394000185 active site 1142394000186 HIGH motif; other site 1142394000187 KMSKS motif; other site 1142394000188 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 1142394000189 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 1142394000190 catalytic residue [active] 1142394000191 putative FPP diphosphate binding site; other site 1142394000192 putative FPP binding hydrophobic cleft; other site 1142394000193 dimer interface [polypeptide binding]; other site 1142394000194 putative IPP diphosphate binding site; other site 1142394000195 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1142394000196 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1142394000197 GDP-binding site [chemical binding]; other site 1142394000198 ACT binding site; other site 1142394000199 IMP binding site; other site 1142394000200 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229; cl15841 1142394000201 SelR domain; Region: SelR; pfam01641 1142394000202 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1142394000203 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1142394000204 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 1142394000205 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1142394000206 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1142394000207 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1142394000208 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1142394000209 catalytic residue [active] 1142394000210 Domain of unknown function (DUF336); Region: DUF336; pfam03928 1142394000211 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1142394000212 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1142394000213 FeS/SAM binding site; other site 1142394000214 Right handed beta helix region; Region: Beta_helix; pfam13229 1142394000215 Tic20-like protein; Region: Tic20; pfam09685 1142394000216 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1142394000217 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1142394000218 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1142394000219 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1142394000220 Domain of unknown function (DUF718); Region: DUF718; pfam05336 1142394000221 Cell division septal protein [Cell envelope biogenesis, outer membrane]; Region: FtsQ; COG1589 1142394000222 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1142394000223 nudix motif; other site 1142394000224 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 1142394000225 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1142394000226 CAP-like domain; other site 1142394000227 active site 1142394000228 primary dimer interface [polypeptide binding]; other site 1142394000229 MoxR-like ATPases [General function prediction only]; Region: COG0714 1142394000230 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1142394000231 Walker A motif; other site 1142394000232 ATP binding site [chemical binding]; other site 1142394000233 Walker B motif; other site 1142394000234 arginine finger; other site 1142394000235 GxxExxY protein; Region: GxxExxY; TIGR04256 1142394000236 Recombination protein O N terminal; Region: RecO_N; pfam11967 1142394000237 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 1142394000238 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 1142394000239 active site 1142394000240 Na/Ca binding site [ion binding]; other site 1142394000241 catalytic site [active] 1142394000242 Protein of unknown function (DUF1232); Region: DUF1232; cl01318 1142394000243 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 1142394000244 PPOX class probable FMN-dependent enzyme, alr4036 family; Region: PPOX_FMN_cyano; TIGR04026 1142394000245 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1142394000246 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 1142394000247 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1142394000248 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1142394000249 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1142394000250 DNA binding residues [nucleotide binding] 1142394000251 dimerization interface [polypeptide binding]; other site 1142394000252 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1142394000253 homopentamer interface [polypeptide binding]; other site 1142394000254 active site 1142394000255 Glycogen debranching enzyme N terminal; Region: GDE_N; pfam12439 1142394000256 Amylo-alpha-1,6-glucosidase; Region: GDE_C; pfam06202 1142394000257 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1142394000258 rRNA methylase, putative, group 3; Region: rRNA_methyl_3; TIGR00186 1142394000259 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1142394000260 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1142394000261 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1142394000262 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1142394000263 dimerization interface [polypeptide binding]; other site 1142394000264 putative ATP binding site [chemical binding]; other site 1142394000265 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 1142394000266 Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate...; Region: PRTase_typeII; cl17275 1142394000267 active site 1142394000268 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 1142394000269 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1142394000270 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1142394000271 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1142394000272 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1142394000273 active site 1142394000274 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 1142394000275 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1142394000276 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1142394000277 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1142394000278 Permease; Region: Permease; pfam02405 1142394000279 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1142394000280 5-formyltetrahydrofolate cyclo-ligase [Coenzyme metabolism]; Region: COG0212; cl00360 1142394000281 Verruc_Plancto-restricted protein; Region: Plancto_Ver_chp; TIGR04138 1142394000282 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 1142394000283 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1142394000284 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1142394000285 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1142394000286 binding surface 1142394000287 TPR motif; other site 1142394000288 flagellin; Validated; Region: PRK08026 1142394000289 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1142394000290 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 1142394000291 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1142394000292 carbon storage regulator; Provisional; Region: PRK01712 1142394000293 FliW protein; Region: FliW; cl00740 1142394000294 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1142394000295 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1142394000296 Flagellar hook-associated protein [Cell motility and secretion]; Region: FlgK; COG1256 1142394000297 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1142394000298 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1142394000299 Flagellar P-ring protein; Region: FlgI; pfam02119 1142394000300 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1142394000301 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 1142394000302 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 1142394000303 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 1142394000304 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 1142394000305 putative active site; other site 1142394000306 catalytic triad [active] 1142394000307 putative dimer interface [polypeptide binding]; other site 1142394000308 Sulfatase; Region: Sulfatase; cl17466 1142394000309 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1142394000310 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1142394000311 Divergent AAA domain; Region: AAA_4; pfam04326 1142394000312 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 1142394000313 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 1142394000314 DNA methylase; Region: N6_N4_Mtase; pfam01555 1142394000315 DNA methylase; Region: N6_N4_Mtase; pfam01555 1142394000316 AAA ATPase domain; Region: AAA_16; pfam13191 1142394000317 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 1142394000318 Family description; Region: UvrD_C_2; pfam13538 1142394000319 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1142394000320 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1142394000321 Walker A motif; other site 1142394000322 ATP binding site [chemical binding]; other site 1142394000323 Walker B motif; other site 1142394000324 arginine finger; other site 1142394000325 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1142394000326 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1142394000327 phosphopeptide binding site; other site 1142394000328 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1142394000329 Type II/IV secretion system protein; Region: T2SE; pfam00437 1142394000330 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1142394000331 Walker A motif; other site 1142394000332 ATP binding site [chemical binding]; other site 1142394000333 Walker B motif; other site 1142394000334 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1142394000335 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1142394000336 metal binding site [ion binding]; metal-binding site 1142394000337 active site 1142394000338 I-site; other site 1142394000339 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1142394000340 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1142394000341 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1142394000342 NAD binding site [chemical binding]; other site 1142394000343 recombinase A; Provisional; Region: recA; PRK09354 1142394000344 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1142394000345 hexamer interface [polypeptide binding]; other site 1142394000346 Walker A motif; other site 1142394000347 ATP binding site [chemical binding]; other site 1142394000348 Walker B motif; other site 1142394000349 DNA polymerase II large subunit; Validated; Region: PRK04023 1142394000350 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1142394000351 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1142394000352 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 1142394000353 active site 1142394000354 NTP binding site [chemical binding]; other site 1142394000355 metal binding triad [ion binding]; metal-binding site 1142394000356 antibiotic binding site [chemical binding]; other site 1142394000357 Nucleotidyltransferase substrate binding protein like; Region: NTase_sub_bind; cl17552 1142394000358 pyridoxamine-phosphate oxidase; Region: pdxH; TIGR00558 1142394000359 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1142394000360 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1142394000361 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 1142394000362 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1142394000363 RNA binding surface [nucleotide binding]; other site 1142394000364 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1142394000365 active site 1142394000366 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 1142394000367 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1142394000368 Walker A/P-loop; other site 1142394000369 ATP binding site [chemical binding]; other site 1142394000370 Q-loop/lid; other site 1142394000371 ABC transporter signature motif; other site 1142394000372 Walker B; other site 1142394000373 D-loop; other site 1142394000374 H-loop/switch region; other site 1142394000375 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1142394000376 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1142394000377 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1142394000378 active site 1142394000379 CoA binding site [chemical binding]; other site 1142394000380 AMP binding site [chemical binding]; other site 1142394000381 NhaP-type Na+/H+ and K+/H+ antiporters [Inorganic ion transport and metabolism]; Region: NhaP; COG0025 1142394000382 ATP synthase A chain; Region: ATP-synt_A; cl00413 1142394000383 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1142394000384 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1142394000385 F0F1-type ATP synthase, delta subunit (mitochondrial oligomycin sensitivity protein) [Energy production and conversion]; Region: AtpH; cl17210 1142394000386 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1142394000387 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1142394000388 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1142394000389 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1142394000390 beta subunit interaction interface [polypeptide binding]; other site 1142394000391 Walker A motif; other site 1142394000392 ATP binding site [chemical binding]; other site 1142394000393 Walker B motif; other site 1142394000394 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1142394000395 alpha-galactosidase; Provisional; Region: PRK15076 1142394000396 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1142394000397 NAD(P) binding site [chemical binding]; other site 1142394000398 LDH/MDH dimer interface [polypeptide binding]; other site 1142394000399 substrate binding site [chemical binding]; other site 1142394000400 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1142394000401 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1142394000402 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1142394000403 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1142394000404 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1142394000405 substrate binding site [chemical binding]; other site 1142394000406 ATP binding site [chemical binding]; other site 1142394000407 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1142394000408 Glycogen synthase; Region: Glycogen_syn; pfam05693 1142394000409 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1142394000410 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1142394000411 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 1142394000412 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1142394000413 putative catalytic residue [active] 1142394000414 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1142394000415 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1142394000416 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1142394000417 prepilin-type processing-associated H-X9-DG domain; Region: pre_pil_HX9DG; TIGR04294 1142394000418 Ribosomal protein S21; Region: Ribosomal_S21; pfam01165 1142394000419 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 1142394000420 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 1142394000421 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 1142394000422 Protein of Unknown function (DUF2784); Region: DUF2784; pfam10861 1142394000423 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1142394000424 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1142394000425 dimer interface [polypeptide binding]; other site 1142394000426 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1142394000427 catalytic residue [active] 1142394000428 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133 1142394000429 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1142394000430 Deoxyhypusine synthase; Region: DS; cl00826 1142394000431 RES domain; Region: RES; pfam08808 1142394000432 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1142394000433 salt bridge; other site 1142394000434 sequence-specific DNA binding site [nucleotide binding]; other site 1142394000435 Protein of unknown function (DUF2384); Region: DUF2384; pfam09722 1142394000436 Paraquat-inducible protein A; Region: PqiA; pfam04403 1142394000437 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1142394000438 TPP-binding site [chemical binding]; other site 1142394000439 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1142394000440 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1142394000441 PYR/PP interface [polypeptide binding]; other site 1142394000442 dimer interface [polypeptide binding]; other site 1142394000443 TPP binding site [chemical binding]; other site 1142394000444 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1142394000445 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1142394000446 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1142394000447 dimer interface [polypeptide binding]; other site 1142394000448 phosphorylation site [posttranslational modification] 1142394000449 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1142394000450 ATP binding site [chemical binding]; other site 1142394000451 Mg2+ binding site [ion binding]; other site 1142394000452 G-X-G motif; other site 1142394000453 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1142394000454 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1142394000455 active site 1142394000456 phosphorylation site [posttranslational modification] 1142394000457 intermolecular recognition site; other site 1142394000458 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1142394000459 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1142394000460 metal binding site [ion binding]; metal-binding site 1142394000461 active site 1142394000462 I-site; other site 1142394000463 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 1142394000464 ParB-like nuclease domain; Region: ParBc; pfam02195 1142394000465 ADP-heptose synthase, bifunctional sugar kinase/adenylyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaE; COG2870 1142394000466 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1142394000467 putative ribose interaction site [chemical binding]; other site 1142394000468 putative ADP binding site [chemical binding]; other site 1142394000469 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1142394000470 active site 1142394000471 nucleotide binding site [chemical binding]; other site 1142394000472 HIGH motif; other site 1142394000473 KMSKS motif; other site 1142394000474 FtsX-like permease family; Region: FtsX; pfam02687 1142394000475 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 1142394000476 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1142394000477 TIGR01777 family protein; Region: yfcH 1142394000478 NAD(P) binding site [chemical binding]; other site 1142394000479 active site 1142394000480 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1142394000481 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1142394000482 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1142394000483 Walker A/P-loop; other site 1142394000484 ATP binding site [chemical binding]; other site 1142394000485 Q-loop/lid; other site 1142394000486 ABC transporter signature motif; other site 1142394000487 Walker B; other site 1142394000488 D-loop; other site 1142394000489 H-loop/switch region; other site 1142394000490 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1142394000491 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1142394000492 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1142394000493 Walker A/P-loop; other site 1142394000494 ATP binding site [chemical binding]; other site 1142394000495 Q-loop/lid; other site 1142394000496 ABC transporter signature motif; other site 1142394000497 Walker B; other site 1142394000498 D-loop; other site 1142394000499 H-loop/switch region; other site 1142394000500 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982 1142394000501 Uncharacterized conserved protein [Function unknown]; Region: COG2928 1142394000502 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1142394000503 30S subunit binding site; other site 1142394000504 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1142394000505 Ligand Binding Site [chemical binding]; other site 1142394000506 Flagellin N-methylase; Region: FliB; pfam03692 1142394000507 Putative ATP-dependant zinc protease; Region: Zn_protease; cl01682 1142394000508 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1142394000509 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1142394000510 TrkA-C domain; Region: TrkA_C; pfam02080 1142394000511 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 1142394000512 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 1142394000513 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1142394000514 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1142394000515 active site 1142394000516 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 1142394000517 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 1142394000518 Protein of unknown function DUF58; Region: DUF58; pfam01882 1142394000519 MoxR-like ATPases [General function prediction only]; Region: COG0714 1142394000520 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1142394000521 Walker A motif; other site 1142394000522 ATP binding site [chemical binding]; other site 1142394000523 Walker B motif; other site 1142394000524 arginine finger; other site 1142394000525 Phosphatidylserine synthase [Lipid metabolism]; Region: PssA; COG1183 1142394000526 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; pfam01066 1142394000527 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1142394000528 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1142394000529 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1142394000530 S-adenosylmethionine binding site [chemical binding]; other site 1142394000531 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 1142394000532 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 1142394000533 Competence protein; Region: Competence; pfam03772 1142394000534 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1142394000535 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 1142394000536 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1142394000537 Glycosyl hydrolases family 39; Region: Glyco_hydro_39; pfam01229 1142394000538 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 1142394000539 mycofactocin system glycosyltransferase; Region: mycofact_glyco; TIGR03965 1142394000540 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1142394000541 This family is most closely related to the GT1 family of glycosyltransferases. WabH in Klebsiella pneumoniae has been shown to transfer a GlcNAc residue from UDP-GlcNAc onto the acceptor GalUA residue in the cellular outer core; Region: GT1_WabH_like; cd03811 1142394000542 putative ADP-binding pocket [chemical binding]; other site 1142394000543 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1142394000544 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1142394000545 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1142394000546 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1142394000547 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1142394000548 active site 1142394000549 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1142394000550 Fucose 4-O-acetylase and related acetyltransferases [Carbohydrate transport and metabolism]; Region: NolL; COG3594 1142394000551 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1142394000552 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1142394000553 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1142394000554 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1142394000555 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1142394000556 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 1142394000557 active site 1142394000558 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1142394000559 extended (e) SDRs; Region: SDR_e; cd08946 1142394000560 NAD(P) binding site [chemical binding]; other site 1142394000561 active site 1142394000562 substrate binding site [chemical binding]; other site 1142394000563 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1142394000564 T5orf172 domain; Region: T5orf172; pfam10544 1142394000565 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1142394000566 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1142394000567 ATP binding site [chemical binding]; other site 1142394000568 putative Mg++ binding site [ion binding]; other site 1142394000569 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1142394000570 non-specific DNA binding site [nucleotide binding]; other site 1142394000571 salt bridge; other site 1142394000572 sequence-specific DNA binding site [nucleotide binding]; other site 1142394000573 Domain of unknown function (DUF955); Region: DUF955; cl01076 1142394000574 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1142394000575 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1142394000576 heme-binding site [chemical binding]; other site 1142394000577 Oligomerisation domain; Region: Oligomerisation; cl00519 1142394000578 Surface presentation of antigens (SPOA); Region: SpoA; cl00819 1142394000579 anthranilate synthase component I; Region: PLN02445 1142394000580 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1142394000581 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1142394000582 Bacterial protein of unknown function (Gcw_chp); Region: Gcw_chp; cl09901 1142394000583 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1142394000584 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 1142394000585 tandem repeat interface [polypeptide binding]; other site 1142394000586 oligomer interface [polypeptide binding]; other site 1142394000587 active site residues [active] 1142394000588 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1142394000589 nucleoside/Zn binding site; other site 1142394000590 dimer interface [polypeptide binding]; other site 1142394000591 catalytic motif [active] 1142394000592 Cytochrome c; Region: Cytochrom_C; cl11414 1142394000593 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1142394000594 trimer interface [polypeptide binding]; other site 1142394000595 active site 1142394000596 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 1142394000597 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 1142394000598 active site 1142394000599 dimer interface [polypeptide binding]; other site 1142394000600 effector binding site; other site 1142394000601 Ribonucleotide reductase, barrel domain; Region: Ribonuc_red_lgC; pfam02867 1142394000602 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1142394000603 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1142394000604 TSCPD domain; Region: TSCPD; pfam12637 1142394000605 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1142394000606 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1142394000607 Domain of unknown function (DUF2383); Region: DUF2383; cl17556 1142394000608 DNA-directed RNA polymerase specialized sigma subunit [Transcription]; Region: FliA; COG1191 1142394000609 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1142394000610 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 1142394000611 DNA binding residues [nucleotide binding] 1142394000612 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1142394000613 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1142394000614 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1142394000615 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1142394000616 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1142394000617 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1142394000618 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1142394000619 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1142394000620 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 1142394000621 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1142394000622 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 1142394000623 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1142394000624 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1142394000625 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1142394000626 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1142394000627 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1142394000628 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1142394000629 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 1142394000630 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 1142394000631 B12 binding domain; Region: B12-binding_2; pfam02607 1142394000632 Predicted cobalamin binding protein [General function prediction only]; Region: COG5012 1142394000633 Peptidase family M48; Region: Peptidase_M48; pfam01435 1142394000634 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 1142394000635 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1142394000636 S-adenosylmethionine binding site [chemical binding]; other site 1142394000637 PA14 domain; Region: PA14; cl08459 1142394000638 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1142394000639 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1142394000640 dimer interface [polypeptide binding]; other site 1142394000641 active site 1142394000642 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1142394000643 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1142394000644 dimer interface [polypeptide binding]; other site 1142394000645 active site 1142394000646 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1142394000647 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1142394000648 TrkA-N domain; Region: TrkA_N; pfam02254 1142394000649 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1142394000650 active site 1142394000651 TatD related DNase; Region: TatD_DNase; pfam01026 1142394000652 RNA methyltransferase; Region: Methyltrans_RNA; cl00611 1142394000653 FeS assembly protein SufD; Region: sufD; TIGR01981 1142394000654 Uncharacterized protein family (UPF0051); Region: UPF0051; pfam01458 1142394000655 FeS assembly ATPase SufC; Region: sufC; TIGR01978 1142394000656 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1142394000657 Walker A/P-loop; other site 1142394000658 ATP binding site [chemical binding]; other site 1142394000659 Q-loop/lid; other site 1142394000660 ABC transporter signature motif; other site 1142394000661 Walker B; other site 1142394000662 D-loop; other site 1142394000663 H-loop/switch region; other site 1142394000664 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1142394000665 putative ABC transporter; Region: ycf24; CHL00085 1142394000666 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1142394000667 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1142394000668 flagellar biosynthesis anti-sigma factor FlgM; Region: FlgM_jcvi; TIGR03824 1142394000669 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1142394000670 dihydropteroate synthase; Region: DHPS; TIGR01496 1142394000671 substrate binding pocket [chemical binding]; other site 1142394000672 dimer interface [polypeptide binding]; other site 1142394000673 inhibitor binding site; inhibition site 1142394000674 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1142394000675 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 1142394000676 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 1142394000677 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1142394000678 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1142394000679 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1142394000680 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1142394000681 TPP-binding site [chemical binding]; other site 1142394000682 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1142394000683 dimer interface [polypeptide binding]; other site 1142394000684 PYR/PP interface [polypeptide binding]; other site 1142394000685 TPP binding site [chemical binding]; other site 1142394000686 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1142394000687 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1142394000688 NAD(P) binding site [chemical binding]; other site 1142394000689 active site 1142394000690 Uncharacterized protein conserved in bacteria (DUF2191); Region: DUF2191; pfam09957 1142394000691 PIN (PilT N terminus) domain: Superfamily; Region: PIN_SF; cl14812 1142394000692 Adenosylhomocysteinase; Provisional; Region: PTZ00075 1142394000693 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 1142394000694 homotetramer interface [polypeptide binding]; other site 1142394000695 ligand binding site [chemical binding]; other site 1142394000696 catalytic site [active] 1142394000697 NAD binding site [chemical binding]; other site 1142394000698 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1142394000699 dimerization interface [polypeptide binding]; other site 1142394000700 putative DNA binding site [nucleotide binding]; other site 1142394000701 putative Zn2+ binding site [ion binding]; other site 1142394000702 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1142394000703 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1142394000704 S-adenosylmethionine binding site [chemical binding]; other site 1142394000705 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1142394000706 TPR motif; other site 1142394000707 binding surface 1142394000708 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 1142394000709 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1142394000710 TPR motif; other site 1142394000711 TPR repeat; Region: TPR_11; pfam13414 1142394000712 binding surface 1142394000713 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1142394000714 binding surface 1142394000715 TPR motif; other site 1142394000716 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 1142394000717 TPR repeat; Region: TPR_11; pfam13414 1142394000718 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1142394000719 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1142394000720 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1142394000721 DNA binding residues [nucleotide binding] 1142394000722 Inositol-monophosphatase-like domains. This family of phosphatases is dependent on bivalent metal ions such as Mg++, and many members are inhibited by Li+ (which is thought to displace a bivalent ion in the active site). Substrates include fructose-1; Region: IMPase_like; cd01637 1142394000723 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1142394000724 active site 1142394000725 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 1142394000726 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1142394000727 putative NAD(P) binding site [chemical binding]; other site 1142394000728 putative active site [active] 1142394000729 Uncharacterized protein conserved in bacteria (DUF2256); Region: DUF2256; pfam10013 1142394000730 phytoene desaturase; Region: crtI_fam; TIGR02734 1142394000731 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1142394000732 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 1142394000733 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1142394000734 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1142394000735 active site 1142394000736 spiro-SPASM protein; Region: spiroSPASM; TIGR04321 1142394000737 Domain of unknown function (DUF4008); Region: DUF4008; pfam13186 1142394000738 Protein of unknown function DUF115; Region: MAF_flag10; pfam01973 1142394000739 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 1142394000740 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cl17708 1142394000741 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1142394000742 domain interfaces; other site 1142394000743 active site 1142394000744 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1142394000745 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 1142394000746 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1142394000747 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 1142394000748 phytoene desaturase; Region: crtI_fam; TIGR02734 1142394000749 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 1142394000750 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1142394000751 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1142394000752 active site 1142394000753 HIGH motif; other site 1142394000754 nucleotide binding site [chemical binding]; other site 1142394000755 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1142394000756 active site 1142394000757 KMSKS motif; other site 1142394000758 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1142394000759 Topoisomerase IB [DNA replication, recombination, and repair]; Region: COG3569 1142394000760 Eukaryotic DNA topoisomerase I, catalytic core; Region: Topoisom_I; pfam01028 1142394000761 active site 1142394000762 DNA binding site [nucleotide binding] 1142394000763 Int/Topo IB signature motif; other site 1142394000764 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1142394000765 Glutaminase; Region: Glutaminase; cl00907 1142394000766 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1142394000767 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1142394000768 DNA polymerase III subunit beta; Validated; Region: PRK05643 1142394000769 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1142394000770 putative DNA binding surface [nucleotide binding]; other site 1142394000771 dimer interface [polypeptide binding]; other site 1142394000772 beta-clamp/clamp loader binding surface; other site 1142394000773 beta-clamp/translesion DNA polymerase binding surface; other site 1142394000774 ABC-type molybdenum transport system, ATPase component/photorepair protein PhrA [Inorganic ion transport and metabolism]; Region: ModF; COG1119 1142394000775 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1142394000776 Walker A/P-loop; other site 1142394000777 ATP binding site [chemical binding]; other site 1142394000778 Q-loop/lid; other site 1142394000779 ABC transporter signature motif; other site 1142394000780 Walker B; other site 1142394000781 D-loop; other site 1142394000782 H-loop/switch region; other site 1142394000783 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1142394000784 23S rRNA binding site [nucleotide binding]; other site 1142394000785 L21 binding site [polypeptide binding]; other site 1142394000786 L13 binding site [polypeptide binding]; other site 1142394000787 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 1142394000788 Clp amino terminal domain; Region: Clp_N; pfam02861 1142394000789 Clp amino terminal domain; Region: Clp_N; pfam02861 1142394000790 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1142394000791 Walker A motif; other site 1142394000792 ATP binding site [chemical binding]; other site 1142394000793 Walker B motif; other site 1142394000794 arginine finger; other site 1142394000795 UvrB/uvrC motif; Region: UVR; pfam02151 1142394000796 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1142394000797 Walker A motif; other site 1142394000798 ATP binding site [chemical binding]; other site 1142394000799 Walker B motif; other site 1142394000800 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1142394000801 HDOD domain; Region: HDOD; pfam08668 1142394000802 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1142394000803 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1142394000804 metal binding site [ion binding]; metal-binding site 1142394000805 active site 1142394000806 I-site; other site 1142394000807 aspartate semialdehyde dehydrogenase; Region: PLN02383 1142394000808 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1142394000809 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1142394000810 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1142394000811 substrate binding site [chemical binding]; other site 1142394000812 ATP binding site [chemical binding]; other site 1142394000813 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1142394000814 PQQ-like domain; Region: PQQ_2; pfam13360 1142394000815 Trp docking motif [polypeptide binding]; other site 1142394000816 active site 1142394000817 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1142394000818 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1142394000819 dimer interface [polypeptide binding]; other site 1142394000820 active site 1142394000821 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1142394000822 folate binding site [chemical binding]; other site 1142394000823 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 1142394000824 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1142394000825 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1142394000826 active site 1142394000827 metal binding site [ion binding]; metal-binding site 1142394000828 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1142394000829 active site 1142394000830 metal binding site [ion binding]; metal-binding site 1142394000831 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1142394000832 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1142394000833 NAD(P) binding site [chemical binding]; other site 1142394000834 active site 1142394000835 Protein of unknown function (DUF4056); Region: DUF4056; pfam13265 1142394000836 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 1142394000837 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1142394000838 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1142394000839 Probable Catalytic site; other site 1142394000840 metal-binding site 1142394000841 serine O-acetyltransferase; Region: cysE; TIGR01172 1142394000842 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1142394000843 trimer interface [polypeptide binding]; other site 1142394000844 active site 1142394000845 substrate binding site [chemical binding]; other site 1142394000846 CoA binding site [chemical binding]; other site 1142394000847 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1142394000848 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1142394000849 active site 1142394000850 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1142394000851 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1142394000852 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1142394000853 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1142394000854 NAD(P) binding site [chemical binding]; other site 1142394000855 active site 1142394000856 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1142394000857 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 1142394000858 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1142394000859 putative ADP-binding pocket [chemical binding]; other site 1142394000860 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1142394000861 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1142394000862 active site 1142394000863 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 1142394000864 putative ADP-binding pocket [chemical binding]; other site 1142394000865 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1142394000866 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1142394000867 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 1142394000868 DXD motif; other site 1142394000869 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1142394000870 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1142394000871 Ligand binding site; other site 1142394000872 Putative Catalytic site; other site 1142394000873 DXD motif; other site 1142394000874 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1142394000875 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1142394000876 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1142394000877 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 1142394000878 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1142394000879 NAD(P) binding site [chemical binding]; other site 1142394000880 active site 1142394000881 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1142394000882 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1142394000883 putative trimer interface [polypeptide binding]; other site 1142394000884 putative CoA binding site [chemical binding]; other site 1142394000885 ribonuclease D; Region: rnd; TIGR01388 1142394000886 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1142394000887 catalytic site [active] 1142394000888 putative active site [active] 1142394000889 putative substrate binding site [chemical binding]; other site 1142394000890 HRDC domain; Region: HRDC; cl02578 1142394000891 Menaquinone biosynthesis; Region: VitK2_biosynth; cl17475 1142394000892 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1142394000893 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1142394000894 putative acyl-acceptor binding pocket; other site 1142394000895 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; cl17405 1142394000896 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1142394000897 NAD(P) binding site [chemical binding]; other site 1142394000898 active site 1142394000899 dTDP-D-glucose 4,6-dehydratase [Cell envelope biogenesis, outer membrane]; Region: RfbB; COG1088 1142394000900 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1142394000901 NAD binding site [chemical binding]; other site 1142394000902 substrate binding site [chemical binding]; other site 1142394000903 homodimer interface [polypeptide binding]; other site 1142394000904 active site 1142394000905 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1142394000906 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1142394000907 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1142394000908 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1142394000909 ABC-type polysaccharide/polyol phosphate export systems, permease component [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: TagG; COG1682 1142394000910 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1142394000911 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1142394000912 Walker A/P-loop; other site 1142394000913 ATP binding site [chemical binding]; other site 1142394000914 Q-loop/lid; other site 1142394000915 ABC transporter signature motif; other site 1142394000916 Walker B; other site 1142394000917 D-loop; other site 1142394000918 H-loop/switch region; other site 1142394000919 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1142394000920 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1142394000921 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1142394000922 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1142394000923 inhibitor-cofactor binding pocket; inhibition site 1142394000924 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1142394000925 catalytic residue [active] 1142394000926 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1142394000927 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1142394000928 Ligand binding site; other site 1142394000929 Putative Catalytic site; other site 1142394000930 DXD motif; other site 1142394000931 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1142394000932 active site 1142394000933 cosubstrate binding site; other site 1142394000934 substrate binding site [chemical binding]; other site 1142394000935 catalytic site [active] 1142394000936 Formyl transferase, C-terminal domain; Region: Formyl_trans_C; pfam02911 1142394000937 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1142394000938 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1142394000939 substrate binding site; other site 1142394000940 tetramer interface; other site 1142394000941 Protein of unknown function DUF115; Region: MAF_flag10; cl17471 1142394000942 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1142394000943 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1142394000944 active site 1142394000945 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 1142394000946 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1142394000947 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1142394000948 Ligand binding site; other site 1142394000949 oligomer interface; other site 1142394000950 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1142394000951 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1142394000952 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1142394000953 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1142394000954 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 1142394000955 heme-binding site [chemical binding]; other site 1142394000956 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1142394000957 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 1142394000958 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1142394000959 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1142394000960 active site 1142394000961 phosphorylation site [posttranslational modification] 1142394000962 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1142394000963 PAS fold; Region: PAS_3; pfam08447 1142394000964 putative active site [active] 1142394000965 heme pocket [chemical binding]; other site 1142394000966 photolyase PhrII; Region: phr2; TIGR00591 1142394000967 DNA photolyase; Region: DNA_photolyase; pfam00875 1142394000968 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1142394000969 beta-carotene 15,15'-monooxygenase, Brp/Blh family; Region: blh_monoox; TIGR03753 1142394000970 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021 1142394000971 Cation transport protein; Region: TrkH; cl17365 1142394000972 Cation transport protein; Region: TrkH; cl17365 1142394000973 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1142394000974 active site 1142394000975 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 1142394000976 Predicted acetyltransferases and hydrolases with the alpha/beta hydrolase fold [General function prediction only]; Region: LipA; COG1075 1142394000977 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1142394000978 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1142394000979 active site 1142394000980 catalytic tetrad [active] 1142394000981 DNA gyrase subunit A; Validated; Region: PRK05560 1142394000982 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1142394000983 CAP-like domain; other site 1142394000984 active site 1142394000985 primary dimer interface [polypeptide binding]; other site 1142394000986 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1142394000987 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1142394000988 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1142394000989 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1142394000990 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1142394000991 GTP-binding protein YchF; Reviewed; Region: PRK09601 1142394000992 YchF GTPase; Region: YchF; cd01900 1142394000993 G1 box; other site 1142394000994 GTP/Mg2+ binding site [chemical binding]; other site 1142394000995 Switch I region; other site 1142394000996 G2 box; other site 1142394000997 Switch II region; other site 1142394000998 G3 box; other site 1142394000999 G4 box; other site 1142394001000 G5 box; other site 1142394001001 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1142394001002 putative DNA modification/repair radical SAM protein; Region: rSAM_link_UDG; TIGR03916 1142394001003 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1142394001004 FeS/SAM binding site; other site 1142394001005 Prenyltransferase-like; Region: Prenyltrans_1; pfam13243 1142394001006 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 1142394001007 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1142394001008 trimer interface [polypeptide binding]; other site 1142394001009 active site 1142394001010 substrate binding site [chemical binding]; other site 1142394001011 CoA binding site [chemical binding]; other site 1142394001012 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1142394001013 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1142394001014 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1142394001015 ATPases of the AAA+ class [Posttranslational modification, protein turnover, chaperones]; Region: SpoVK; COG0464 1142394001016 ATPase family associated with various cellular activities (AAA); Region: AAA; pfam00004 1142394001017 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1142394001018 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4307 1142394001019 Uncharacterized protein conserved in bacteria (DUF2248); Region: DUF2248; pfam10005 1142394001020 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 1142394001021 Protein of unknown function (DUF1371); Region: DUF1371; pfam07115 1142394001022 PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595 1142394001023 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1142394001024 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 1142394001025 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1142394001026 catalytic site [active] 1142394001027 subunit interface [polypeptide binding]; other site 1142394001028 Uracil-DNA glycosylases (UDG) and related enzymes; Region: UDG_like; cl00483 1142394001029 ligand binding site [chemical binding]; other site 1142394001030 active site 1142394001031 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1142394001032 ligand binding site [chemical binding]; other site 1142394001033 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1142394001034 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1142394001035 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1142394001036 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1142394001037 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1142394001038 DNA binding residues [nucleotide binding] 1142394001039 Sulfatase; Region: Sulfatase; cl17466 1142394001040 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1142394001041 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1142394001042 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1142394001043 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1142394001044 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1142394001045 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1142394001046 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1142394001047 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1142394001048 active site 1142394001049 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 1142394001050 active site 1142394001051 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1142394001052 amidase catalytic site [active] 1142394001053 Zn binding residues [ion binding]; other site 1142394001054 substrate binding site [chemical binding]; other site 1142394001055 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1142394001056 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1142394001057 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1142394001058 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1142394001059 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1142394001060 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1142394001061 PilZ domain; Region: PilZ; pfam07238 1142394001062 PilZ domain; Region: PilZ; pfam07238 1142394001063 Acyl-CoA synthetases (AMP-forming)/AMP-acid ligases II [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: CaiC; COG0318 1142394001064 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1142394001065 acyl-activating enzyme (AAE) consensus motif; other site 1142394001066 AMP binding site [chemical binding]; other site 1142394001067 active site 1142394001068 CoA binding site [chemical binding]; other site 1142394001069 putative acyl transferase; Provisional; Region: PRK10191 1142394001070 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 1142394001071 trimer interface [polypeptide binding]; other site 1142394001072 active site 1142394001073 substrate binding site [chemical binding]; other site 1142394001074 CoA binding site [chemical binding]; other site 1142394001075 Domain of unknown function (DUF4130; Region: DUF4130; cl14836 1142394001076 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1142394001077 Fe-S cluster binding site [ion binding]; other site 1142394001078 active site 1142394001079 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1142394001080 Uncharacterized subgroup of the nitrilase superfamily; some members of this subgroup have an N-terminal RimI domain (class 12 nitrilases); Region: nitrilase_Rim1_like; cd07574 1142394001081 putative active site [active] 1142394001082 catalytic triad [active] 1142394001083 putative dimer interface [polypeptide binding]; other site 1142394001084 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1142394001085 Coenzyme A binding pocket [chemical binding]; other site 1142394001086 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 1142394001087 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1142394001088 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1142394001089 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1142394001090 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1142394001091 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1142394001092 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1142394001093 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1142394001094 Sulfatase; Region: Sulfatase; pfam00884 1142394001095 hypothetical protein; Provisional; Region: PRK11820 1142394001096 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1142394001097 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1142394001098 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1142394001099 substrate binding site [chemical binding]; other site 1142394001100 dimer interface [polypeptide binding]; other site 1142394001101 catalytic triad [active] 1142394001102 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 1142394001103 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1142394001104 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1142394001105 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1142394001106 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1142394001107 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1142394001108 delta-60 repeat domain; Region: delta_60_rpt; TIGR02608 1142394001109 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 1142394001110 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1142394001111 MULE transposase domain; Region: MULE; pfam10551 1142394001112 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1142394001113 binding surface 1142394001114 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1142394001115 TPR motif; other site 1142394001116 Bacterial Fe(2+) trafficking; Region: Iron_traffic; cl01104 1142394001117 CYTH-like (also known as triphosphate tunnel metalloenzyme (TTM)-like) Phosphatases; Region: CYTH-like_Pase; cl11964 1142394001118 putative active site; other site 1142394001119 putative metal binding residues [ion binding]; other site 1142394001120 signature motif; other site 1142394001121 putative triphosphate binding site [ion binding]; other site 1142394001122 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1142394001123 dimer interface [polypeptide binding]; other site 1142394001124 phosphorylation site [posttranslational modification] 1142394001125 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1142394001126 ATP binding site [chemical binding]; other site 1142394001127 G-X-G motif; other site 1142394001128 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1142394001129 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1142394001130 dimer interface [polypeptide binding]; other site 1142394001131 conserved gate region; other site 1142394001132 ABC-ATPase subunit interface; other site 1142394001133 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1142394001134 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1142394001135 dimer interface [polypeptide binding]; other site 1142394001136 conserved gate region; other site 1142394001137 putative PBP binding loops; other site 1142394001138 ABC-ATPase subunit interface; other site 1142394001139 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 1142394001140 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1142394001141 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1142394001142 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1142394001143 Transposase domain (DUF772); Region: DUF772; pfam05598 1142394001144 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1142394001145 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1142394001146 Formyltetrahydrofolate hydrolase [Nucleotide transport and metabolism]; Region: PurU; COG0788 1142394001147 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1142394001148 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 1142394001149 active site 1142394001150 substrate binding site [chemical binding]; other site 1142394001151 cosubstrate binding site; other site 1142394001152 catalytic site [active] 1142394001153 UDP-N-acetylmuramyl-tripeptide synthetase; Region: murE; TIGR01085 1142394001154 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1142394001155 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1142394001156 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1142394001157 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1142394001158 active site 1142394001159 ATP binding site [chemical binding]; other site 1142394001160 substrate binding site [chemical binding]; other site 1142394001161 activation loop (A-loop); other site 1142394001162 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 1142394001163 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1142394001164 Predicted transcriptional regulator [Transcription]; Region: COG1959 1142394001165 Transcriptional regulator; Region: Rrf2; pfam02082 1142394001166 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1142394001167 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 1142394001168 inhibitor-cofactor binding pocket; inhibition site 1142394001169 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1142394001170 catalytic residue [active] 1142394001171 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1142394001172 active site 1142394001173 catalytic residue [active] 1142394001174 dimer interface [polypeptide binding]; other site 1142394001175 shikimate 5-dehydrogenase; Reviewed; Region: aroE; PRK00258 1142394001176 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1142394001177 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1142394001178 NAD(P) binding site [chemical binding]; other site 1142394001179 shikimate binding site; other site 1142394001180 DinB superfamily; Region: DinB_2; pfam12867 1142394001181 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1142394001182 phosphomannomutase/phosphoglucomutase; Reviewed; Region: manB; PRK09542 1142394001183 active site 1142394001184 substrate binding site [chemical binding]; other site 1142394001185 metal binding site [ion binding]; metal-binding site 1142394001186 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1142394001187 Catalytic NodB homology domain of rhizobial NodB-like proteins; Region: CE4_NodB_like_6s_7s; cd10917 1142394001188 NodB motif; other site 1142394001189 active site 1142394001190 catalytic site [active] 1142394001191 metal binding site [ion binding]; metal-binding site 1142394001192 Aspartyl protease; Region: Asp_protease_2; pfam13650 1142394001193 inhibitor binding site; inhibition site 1142394001194 catalytic motif [active] 1142394001195 Catalytic residue [active] 1142394001196 Active site flap [active] 1142394001197 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1142394001198 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1142394001199 active site 1142394001200 nucleotide binding site [chemical binding]; other site 1142394001201 HIGH motif; other site 1142394001202 KMSKS motif; other site 1142394001203 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1142394001204 Walker A motif; other site 1142394001205 ATP binding site [chemical binding]; other site 1142394001206 Walker B motif; other site 1142394001207 arginine finger; other site 1142394001208 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1142394001209 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1142394001210 DnaA box-binding interface [nucleotide binding]; other site 1142394001211 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 1142394001212 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1142394001213 active site 1142394001214 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1142394001215 Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases) [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: FabG; COG1028 1142394001216 NAD(P) binding site [chemical binding]; other site 1142394001217 active site 1142394001218 Protein of unknown function (DUF3072); Region: DUF3072; pfam11272 1142394001219 Fic family protein [Function unknown]; Region: COG3177 1142394001220 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 1142394001221 Fic/DOC family; Region: Fic; pfam02661 1142394001222 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1142394001223 GcpE protein; Region: GcpE; pfam04551 1142394001224 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1142394001225 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1142394001226 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1142394001227 prephenate dehydrogenase; Validated; Region: PRK08507 1142394001228 Prephenate dehydrogenase [Amino acid transport and metabolism]; Region: TyrA; COG0287 1142394001229 flagellin; Provisional; Region: PRK12806 1142394001230 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1142394001231 Flagellin hook IN motif; Region: Flagellin_IN; pfam07196 1142394001232 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1142394001233 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 1142394001234 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1142394001235 Walker A motif; other site 1142394001236 ATP binding site [chemical binding]; other site 1142394001237 Walker B motif; other site 1142394001238 arginine finger; other site 1142394001239 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1142394001240 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1142394001241 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1142394001242 active site 1142394001243 bifunctional UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase/(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase; Reviewed; Region: PRK13188 1142394001244 UDP-3-O-acyl-N-acetylglucosamine deacetylase [Cell envelope biogenesis, outer membrane]; Region: LpxC; cl00512 1142394001245 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1142394001246 glutamine synthetase, type I; Region: GlnA; TIGR00653 1142394001247 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1142394001248 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1142394001249 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1142394001250 16S/18S rRNA binding site [nucleotide binding]; other site 1142394001251 S13e-L30e interaction site [polypeptide binding]; other site 1142394001252 25S rRNA binding site [nucleotide binding]; other site 1142394001253 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1142394001254 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1142394001255 inhibitor-cofactor binding pocket; inhibition site 1142394001256 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1142394001257 catalytic residue [active] 1142394001258 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 1142394001259 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 1142394001260 ligand binding site [chemical binding]; other site 1142394001261 NAD binding site [chemical binding]; other site 1142394001262 dimerization interface [polypeptide binding]; other site 1142394001263 catalytic site [active] 1142394001264 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 1142394001265 putative L-serine binding site [chemical binding]; other site 1142394001266 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1142394001267 endonuclease III; Region: ENDO3c; smart00478 1142394001268 minor groove reading motif; other site 1142394001269 helix-hairpin-helix signature motif; other site 1142394001270 substrate binding pocket [chemical binding]; other site 1142394001271 active site 1142394001272 Protein of unknown function (DUF1569); Region: DUF1569; pfam07606 1142394001273 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1142394001274 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1142394001275 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1142394001276 RNA binding domain of NusB (N protein-Utilization Substance B) and Sun (also known as RrmB or Fmu) proteins. This family includes two orthologous groups exemplified by the transcription termination factor NusB and the N-terminal domain of the...; Region: NusB_Sun; cd00447 1142394001277 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1142394001278 S-adenosylmethionine binding site [chemical binding]; other site 1142394001279 Bifunctional nuclease; Region: DNase-RNase; pfam02577 1142394001280 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 1142394001281 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 1142394001282 Putative zinc ribbon domain; Region: DUF164; pfam02591 1142394001283 Fructosamine kinase; Region: Fructosamin_kin; cl17579 1142394001284 Phosphotransferase enzyme family; Region: APH; pfam01636 1142394001285 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1142394001286 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1142394001287 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1142394001288 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1142394001289 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1142394001290 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 1142394001291 Protein of unknown function (DUF1237); Region: DUF1237; pfam06824 1142394001292 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1142394001293 alpha-mannosidase; Provisional; Region: PRK09819 1142394001294 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1142394001295 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1142394001296 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1142394001297 DNA-binding site [nucleotide binding]; DNA binding site 1142394001298 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1142394001299 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1142394001300 ligand binding site [chemical binding]; other site 1142394001301 dimerization interface [polypeptide binding]; other site 1142394001302 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 1142394001303 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1142394001304 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1142394001305 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1142394001306 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1142394001307 putative active site [active] 1142394001308 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1142394001309 catalytic loop [active] 1142394001310 iron binding site [ion binding]; other site 1142394001311 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1142394001312 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1142394001313 FeS/SAM binding site; other site 1142394001314 Uncharacterized conserved protein (DUF2293); Region: DUF2293; cl02373 1142394001315 Phosphoenolpyruvate carboxylase; Region: PEPcase; cl17418 1142394001316 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 1142394001317 Protein of unknown function (DUF1194); Region: DUF1194; pfam06707 1142394001318 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1142394001319 AMP binding site [chemical binding]; other site 1142394001320 metal binding site [ion binding]; metal-binding site 1142394001321 active site 1142394001322 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1142394001323 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1142394001324 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1142394001325 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1142394001326 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1142394001327 Walker A/P-loop; other site 1142394001328 ATP binding site [chemical binding]; other site 1142394001329 Q-loop/lid; other site 1142394001330 ABC transporter signature motif; other site 1142394001331 Walker B; other site 1142394001332 D-loop; other site 1142394001333 H-loop/switch region; other site 1142394001334 Glycosyl transferase family 2; Region: Glyco_tranf_2_4; pfam13704 1142394001335 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1142394001336 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1142394001337 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1142394001338 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1142394001339 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1142394001340 Predicted membrane protein (DUF2243); Region: DUF2243; pfam10002 1142394001341 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727 1142394001342 Uncharacterized conserved protein [Function unknown]; Region: COG2442 1142394001343 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4634 1142394001344 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1142394001345 S-adenosylmethionine binding site [chemical binding]; other site 1142394001346 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 1142394001347 putative catalytic site [active] 1142394001348 putative metal binding site [ion binding]; other site 1142394001349 putative phosphate binding site [ion binding]; other site 1142394001350 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 1142394001351 putative monovalent cation/H+ antiporter subunit E; Reviewed; Region: PRK12651 1142394001352 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1142394001353 putative monovalent cation/H+ antiporter subunit C; Reviewed; Region: PRK12659 1142394001354 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1142394001355 putative monovalent cation/H+ antiporter subunit A; Reviewed; Region: PRK12647 1142394001356 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1142394001357 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1142394001358 Predicted permease [General function prediction only]; Region: COG3329 1142394001359 putative monovalent cation/H+ antiporter subunit G; Reviewed; Region: PRK12674 1142394001360 Multiple resistance and pH regulation protein F (MrpF / PhaF); Region: MrpF_PhaF; cl09154 1142394001361 Na+/H+ ion antiporter subunit; Region: MNHE; pfam01899 1142394001362 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1142394001363 Multisubunit Na+/H+ antiporter, MnhC subunit [Inorganic ion transport and metabolism]; Region: MnhC; COG1006 1142394001364 Domain of unknown function (DUF4040); Region: DUF4040; cl00676 1142394001365 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1142394001366 Multisubunit Na+/H+ antiporter, MnhB subunit [Inorganic ion transport and metabolism]; Region: MnhB; COG2111 1142394001367 PilZ domain; Region: PilZ; pfam07238 1142394001368 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1142394001369 active site 1142394001370 SAM binding site [chemical binding]; other site 1142394001371 homodimer interface [polypeptide binding]; other site 1142394001372 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1142394001373 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1142394001374 active site 1142394001375 Isochorismatase family; Region: Isochorismatase; pfam00857 1142394001376 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1142394001377 catalytic triad [active] 1142394001378 conserved cis-peptide bond; other site 1142394001379 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1142394001380 active site 2 [active] 1142394001381 active site 1 [active] 1142394001382 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1142394001383 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1142394001384 Beta-galactosidase C-terminal domain; Region: Glyco_hydro_42C; pfam08533 1142394001385 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1142394001386 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1142394001387 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1142394001388 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 1142394001389 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1142394001390 Carbohydrate binding domain; Region: CBM_4_9; pfam02018 1142394001391 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 1142394001392 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-C; cd09721 1142394001393 Domain of unknown function DUF83; Region: Cas_Cas4; pfam01930 1142394001394 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-C; cd09689 1142394001395 CRISPR/Cas system-associated protein Cas8c; Region: Cas8c_I-C; cd09757 1142394001396 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-C; cd09752 1142394001397 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1142394001398 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1142394001399 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1142394001400 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 1142394001401 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1142394001402 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1142394001403 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1142394001404 Ribosomal protein S16 [Translation, ribosomal structure and biogenesis]; Region: RpsP; COG0228 1142394001405 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 1142394001406 sucrose-phosphate synthase, putative, glycosyltransferase domain; Region: sucr_P_syn_N; TIGR02472 1142394001407 putative ADP-binding pocket [chemical binding]; other site 1142394001408 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 1142394001409 histidyl-tRNA synthetase; Region: hisS; TIGR00442 1142394001410 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1142394001411 dimer interface [polypeptide binding]; other site 1142394001412 motif 1; other site 1142394001413 active site 1142394001414 motif 2; other site 1142394001415 motif 3; other site 1142394001416 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1142394001417 anticodon binding site; other site 1142394001418 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1142394001419 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1142394001420 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1142394001421 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1142394001422 metal binding site 2 [ion binding]; metal-binding site 1142394001423 putative DNA binding helix; other site 1142394001424 metal binding site 1 [ion binding]; metal-binding site 1142394001425 dimer interface [polypeptide binding]; other site 1142394001426 structural Zn2+ binding site [ion binding]; other site 1142394001427 prepilin-type processing-associated H-X9-DG domain; Region: pre_pil_HX9DG; TIGR04294 1142394001428 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1142394001429 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1142394001430 active site 1142394001431 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Region: lipid_A_lpxD; TIGR01853 1142394001432 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1142394001433 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1142394001434 trimer interface [polypeptide binding]; other site 1142394001435 active site 1142394001436 UDP-GlcNAc binding site [chemical binding]; other site 1142394001437 lipid binding site [chemical binding]; lipid-binding site 1142394001438 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 1142394001439 outer membrane protein assembly complex, YaeT protein; Region: OM_YaeT; TIGR03303 1142394001440 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1142394001441 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1142394001442 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1142394001443 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1142394001444 Surface antigen; Region: Bac_surface_Ag; pfam01103 1142394001445 3-isopropylmalate dehydratase small subunit; Reviewed; Region: leuD; PRK00439 1142394001446 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1142394001447 substrate binding site [chemical binding]; other site 1142394001448 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 1142394001449 FAD binding domain; Region: FAD_binding_4; pfam01565 1142394001450 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1142394001451 BNR repeat-like domain; Region: BNR_2; pfam13088 1142394001452 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1142394001453 Sulfatase; Region: Sulfatase; cl17466 1142394001454 Sulfatase; Region: Sulfatase; cl17466 1142394001455 Sulfatase; Region: Sulfatase; cl17466 1142394001456 DNA polymerase I; Provisional; Region: PRK05755 1142394001457 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1142394001458 active site 1142394001459 metal binding site 1 [ion binding]; metal-binding site 1142394001460 putative 5' ssDNA interaction site; other site 1142394001461 metal binding site 3; metal-binding site 1142394001462 metal binding site 2 [ion binding]; metal-binding site 1142394001463 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1142394001464 putative DNA binding site [nucleotide binding]; other site 1142394001465 putative metal binding site [ion binding]; other site 1142394001466 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1142394001467 active site 1142394001468 catalytic site [active] 1142394001469 substrate binding site [chemical binding]; other site 1142394001470 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1142394001471 active site 1142394001472 DNA binding site [nucleotide binding] 1142394001473 catalytic site [active] 1142394001474 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 1142394001475 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1142394001476 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1142394001477 dimer interface [polypeptide binding]; other site 1142394001478 active site 1142394001479 catalytic residue [active] 1142394001480 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1142394001481 S-adenosylmethionine binding site [chemical binding]; other site 1142394001482 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1142394001483 putative active site [active] 1142394001484 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1142394001485 S-adenosylmethionine binding site [chemical binding]; other site 1142394001486 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1142394001487 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1142394001488 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1142394001489 RNA binding surface [nucleotide binding]; other site 1142394001490 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1142394001491 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1142394001492 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1142394001493 CoA-binding site [chemical binding]; other site 1142394001494 ATP-binding [chemical binding]; other site 1142394001495 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1142394001496 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 1142394001497 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1142394001498 RNA binding site [nucleotide binding]; other site 1142394001499 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1142394001500 Walker A motif; other site 1142394001501 ATP binding site [chemical binding]; other site 1142394001502 Walker B motif; other site 1142394001503 Holliday junction resolvasome, DNA-binding subunit [DNA replication, recombination, and repair]; Region: RuvA; COG0632 1142394001504 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 1142394001505 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1142394001506 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1142394001507 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 1142394001508 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1142394001509 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1142394001510 ABC1 family; Region: ABC1; cl17513 1142394001511 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 1142394001512 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1142394001513 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1142394001514 Tetramer interface [polypeptide binding]; other site 1142394001515 active site 1142394001516 FMN-binding site [chemical binding]; other site 1142394001517 PEGA domain; Region: PEGA; pfam08308 1142394001518 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 1142394001519 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 1142394001520 Protein of unknown function (DUF3341); Region: DUF3341; pfam11821 1142394001521 Polysulphide reductase [Energy production and conversion]; Region: COG5557; cl17901 1142394001522 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 1142394001523 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1142394001524 molybdopterin cofactor binding site; other site 1142394001525 The MopB_CT_PHLH CD includes a group of related uncharacterized putative hydrogenase-like homologs (PHLH) of molybdopterin binding proteins. This CD is of the PHLH region homologous to the conserved molybdopterin-binding C-terminal (MopB_CT) region...; Region: MopB_CT_PHLH; cd02784 1142394001526 4Fe-4S binding domain; Region: Fer4; cl02805 1142394001527 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1142394001528 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 1142394001529 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 1142394001530 heme-binding residues [chemical binding]; other site 1142394001531 Members of the ICL/PEPM_KPHMT enzyme superfamily catalyze the formation and cleavage of either P-C or C-C bonds. Typical members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate...; Region: ICL_KPHMT; cl00435 1142394001532 oligomerization interface [polypeptide binding]; other site 1142394001533 active site 1142394001534 metal binding site [ion binding]; metal-binding site 1142394001535 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1142394001536 active site 1142394001537 lipid kinase YegS; Region: lip_kinase_YegS; TIGR03702 1142394001538 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1142394001539 Predicted transcriptional regulators [Transcription]; Region: COG1695 1142394001540 Transcriptional regulator PadR-like family; Region: PadR; cl17335 1142394001541 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 1142394001542 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1142394001543 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1142394001544 dimerization interface [polypeptide binding]; other site 1142394001545 ATP binding site [chemical binding]; other site 1142394001546 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1142394001547 dimerization interface [polypeptide binding]; other site 1142394001548 ATP binding site [chemical binding]; other site 1142394001549 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1142394001550 TPR motif; other site 1142394001551 binding surface 1142394001552 TPR repeat; Region: TPR_11; pfam13414 1142394001553 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1142394001554 binding surface 1142394001555 TPR motif; other site 1142394001556 TPR repeat; Region: TPR_11; pfam13414 1142394001557 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1142394001558 binding surface 1142394001559 TPR motif; other site 1142394001560 TPR repeat; Region: TPR_11; pfam13414 1142394001561 Outer membrane efflux protein; Region: OEP; pfam02321 1142394001562 Outer membrane efflux protein; Region: OEP; pfam02321 1142394001563 fimbrial isopeptide formation D2 domain; Region: RrgB_K2N_iso_D2; TIGR04226 1142394001564 HlyD family secretion protein; Region: HlyD_3; pfam13437 1142394001565 HlyD family secretion protein; Region: HlyD_3; pfam13437 1142394001566 Predicted transcriptional regulator [Transcription]; Region: COG2378 1142394001567 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1142394001568 putative switch regulator; other site 1142394001569 non-specific DNA interactions [nucleotide binding]; other site 1142394001570 DNA binding site [nucleotide binding] 1142394001571 sequence specific DNA binding site [nucleotide binding]; other site 1142394001572 putative cAMP binding site [chemical binding]; other site 1142394001573 WYL domain; Region: WYL; pfam13280 1142394001574 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1142394001575 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1142394001576 active site 1142394001577 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cd06551 1142394001578 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1142394001579 putative acyl-acceptor binding pocket; other site 1142394001580 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1142394001581 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1142394001582 putative acyl-acceptor binding pocket; other site 1142394001583 O-antigen ligase like membrane protein; Region: O-antigen_lig; pfam13425 1142394001584 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 1142394001585 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 1142394001586 putative active site [active] 1142394001587 PhoH-like protein; Region: PhoH; pfam02562 1142394001588 DNA protecting protein DprA; Region: dprA; TIGR00732 1142394001589 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 1142394001590 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 1142394001591 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 1142394001592 putative dimer interface [polypeptide binding]; other site 1142394001593 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1142394001594 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1142394001595 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1142394001596 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 1142394001597 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 1142394001598 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 1142394001599 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1142394001600 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1142394001601 iron-sulfur cluster [ion binding]; other site 1142394001602 [2Fe-2S] cluster binding site [ion binding]; other site 1142394001603 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 1142394001604 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 1142394001605 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1142394001606 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14611 1142394001607 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1142394001608 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1142394001609 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1142394001610 active site 1142394001611 Cell cycle protein; Region: FTSW_RODA_SPOVE; cl00511 1142394001612 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1142394001613 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1142394001614 Glycosyl hydrolase family 52; Region: Glyco_hydro_52; pfam03512 1142394001615 Exodeoxyribonuclease V, gamma subunit; Region: Exonuc_V_gamma; pfam04257 1142394001616 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1142394001617 exodeoxyribonuclease V, beta subunit; Region: recB; TIGR00609 1142394001618 Family description; Region: UvrD_C_2; pfam13538 1142394001619 AAA domain; Region: AAA_30; pfam13604 1142394001620 Family description; Region: UvrD_C_2; pfam13538 1142394001621 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1142394001622 conserved cys residue [active] 1142394001623 Nodulation formation efficiency D (NfeD) is a membrane-bound ClpP-class protease; Region: Clp_protease_NfeD_like; cd07021 1142394001624 dimer interface [polypeptide binding]; other site 1142394001625 active site residues [active] 1142394001626 tRNA synthetases class I (I, L, M and V); Region: tRNA-synt_1; pfam00133 1142394001627 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1142394001628 active site 1142394001629 HIGH motif; other site 1142394001630 nucleotide binding site [chemical binding]; other site 1142394001631 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1142394001632 active site 1142394001633 KMSKS motif; other site 1142394001634 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1142394001635 tRNA binding surface [nucleotide binding]; other site 1142394001636 anticodon binding site; other site 1142394001637 Anticodon-binding domain of tRNA; Region: Anticodon_1; pfam08264 1142394001638 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 1142394001639 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 1142394001640 Protein of unknown function (DUF968); Region: DUF968; pfam06147 1142394001641 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1142394001642 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1142394001643 putative substrate translocation pore; other site 1142394001644 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06416 1142394001645 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 1142394001646 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1142394001647 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1142394001648 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1142394001649 gamma subunit interface [polypeptide binding]; other site 1142394001650 epsilon subunit interface [polypeptide binding]; other site 1142394001651 LBP interface [polypeptide binding]; other site 1142394001652 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1142394001653 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1142394001654 rod shape-determining protein RodA; Region: rodA_shape; TIGR02210 1142394001655 Fasciclin domain; Region: Fasciclin; pfam02469 1142394001656 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cl00264 1142394001657 dinuclear metal binding motif [ion binding]; other site 1142394001658 ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594 1142394001659 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1142394001660 G1 box; other site 1142394001661 GTP/Mg2+ binding site [chemical binding]; other site 1142394001662 Switch I region; other site 1142394001663 G2 box; other site 1142394001664 Switch II region; other site 1142394001665 G3 box; other site 1142394001666 G4 box; other site 1142394001667 G5 box; other site 1142394001668 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1142394001669 G1 box; other site 1142394001670 GTP/Mg2+ binding site [chemical binding]; other site 1142394001671 Switch I region; other site 1142394001672 G2 box; other site 1142394001673 G3 box; other site 1142394001674 Switch II region; other site 1142394001675 G4 box; other site 1142394001676 G5 box; other site 1142394001677 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1142394001678 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1142394001679 Walker A/P-loop; other site 1142394001680 ATP binding site [chemical binding]; other site 1142394001681 Q-loop/lid; other site 1142394001682 ABC transporter signature motif; other site 1142394001683 Walker B; other site 1142394001684 D-loop; other site 1142394001685 H-loop/switch region; other site 1142394001686 TOBE domain; Region: TOBE_2; pfam08402 1142394001687 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 1142394001688 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1142394001689 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1142394001690 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1142394001691 dimer interface [polypeptide binding]; other site 1142394001692 Citrate synthase; Region: Citrate_synt; pfam00285 1142394001693 active site 1142394001694 citrylCoA binding site [chemical binding]; other site 1142394001695 NADH binding [chemical binding]; other site 1142394001696 cationic pore residues; other site 1142394001697 oxalacetate/citrate binding site [chemical binding]; other site 1142394001698 coenzyme A binding site [chemical binding]; other site 1142394001699 catalytic triad [active] 1142394001700 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 1142394001701 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1142394001702 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1142394001703 metal binding site [ion binding]; metal-binding site 1142394001704 active site 1142394001705 I-site; other site 1142394001706 elongation factor Tu; Reviewed; Region: PRK00049 1142394001707 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1142394001708 G1 box; other site 1142394001709 GEF interaction site [polypeptide binding]; other site 1142394001710 GTP/Mg2+ binding site [chemical binding]; other site 1142394001711 Switch I region; other site 1142394001712 G2 box; other site 1142394001713 G3 box; other site 1142394001714 Switch II region; other site 1142394001715 G4 box; other site 1142394001716 G5 box; other site 1142394001717 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1142394001718 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1142394001719 Antibiotic Binding Site [chemical binding]; other site 1142394001720 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1142394001721 SecE/Sec61-gamma subunits of protein translocation complex; Region: SecE; pfam00584 1142394001722 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1142394001723 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1142394001724 putative homodimer interface [polypeptide binding]; other site 1142394001725 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1142394001726 heterodimer interface [polypeptide binding]; other site 1142394001727 homodimer interface [polypeptide binding]; other site 1142394001728 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 1142394001729 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1142394001730 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1142394001731 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1142394001732 Actin-like ATPase involved in cell morphogenesis [Cell division and chromosome partitioning]; Region: MreB; COG1077 1142394001733 nucleotide binding site [chemical binding]; other site 1142394001734 hypothetical protein; Validated; Region: PRK09104 1142394001735 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 1142394001736 metal binding site [ion binding]; metal-binding site 1142394001737 putative dimer interface [polypeptide binding]; other site 1142394001738 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1142394001739 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1142394001740 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1142394001741 dimer interface [polypeptide binding]; other site 1142394001742 catalytic triad [active] 1142394001743 peroxidatic and resolving cysteines [active] 1142394001744 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 1142394001745 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 1142394001746 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1142394001747 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1142394001748 23S rRNA interface [nucleotide binding]; other site 1142394001749 putative thiostrepton binding site; other site 1142394001750 L7/L12 interface [polypeptide binding]; other site 1142394001751 L25 interface [polypeptide binding]; other site 1142394001752 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1142394001753 mRNA/rRNA interface [nucleotide binding]; other site 1142394001754 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1142394001755 23S rRNA interface [nucleotide binding]; other site 1142394001756 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1142394001757 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1142394001758 peripheral dimer interface [polypeptide binding]; other site 1142394001759 core dimer interface [polypeptide binding]; other site 1142394001760 L10 interface [polypeptide binding]; other site 1142394001761 L11 interface [polypeptide binding]; other site 1142394001762 putative EF-Tu interaction site [polypeptide binding]; other site 1142394001763 putative EF-G interaction site [polypeptide binding]; other site 1142394001764 Ribosomal L28 family; Region: Ribosomal_L28; cl00367 1142394001765 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1142394001766 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1142394001767 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1142394001768 active site 1142394001769 metal binding site [ion binding]; metal-binding site 1142394001770 interdomain interaction site; other site 1142394001771 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1142394001772 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1142394001773 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 1142394001774 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1142394001775 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1142394001776 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1142394001777 DNA binding residues [nucleotide binding] 1142394001778 PilZ domain; Region: PilZ; pfam07238 1142394001779 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1142394001780 HSP70 interaction site [polypeptide binding]; other site 1142394001781 cytidylate kinase; Provisional; Region: cmk; PRK00023 1142394001782 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1142394001783 CMP-binding site; other site 1142394001784 The sites determining sugar specificity; other site 1142394001785 S-AdoMet dependent tetrapyrrole methylases; Region: TP_methylase; cl00304 1142394001786 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1142394001787 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1142394001788 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1142394001789 Helix-turn-helix domain; Region: HTH_18; pfam12833 1142394001790 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 1142394001791 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1142394001792 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 1142394001793 NAD(P) binding site [chemical binding]; other site 1142394001794 active site 1142394001795 Mitochondrial small ribosomal subunit Rsm22; Region: Rsm22; cl17847 1142394001796 sulfite reductase subunit beta; Provisional; Region: PRK13504 1142394001797 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1142394001798 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 1142394001799 putative ligand binding site [chemical binding]; other site 1142394001800 Creatinine amidohydrolase; Region: Creatininase; pfam02633 1142394001801 alpha-galactosidase; Region: PLN02808; cl17638 1142394001802 Uncharacterized conserved protein [Function unknown]; Region: COG3379 1142394001803 Uncharacterized conserved protein [Function unknown]; Region: COG3379 1142394001804 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1142394001805 binding surface 1142394001806 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1142394001807 TPR motif; other site 1142394001808 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1142394001809 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1142394001810 extended (e) SDRs; Region: SDR_e; cd08946 1142394001811 NAD(P) binding site [chemical binding]; other site 1142394001812 active site 1142394001813 substrate binding site [chemical binding]; other site 1142394001814 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 1142394001815 putative ligand binding site [chemical binding]; other site 1142394001816 Trehalase; Region: Trehalase; cl17346 1142394001817 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1142394001818 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1142394001819 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1142394001820 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 1142394001821 Uncharacterized conserved protein [Function unknown]; Region: COG5476 1142394001822 Protein of unknown function (DUF1485); Region: DUF1485; pfam07364 1142394001823 MlrC C-terminus; Region: MlrC_C; pfam07171 1142394001824 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 1142394001825 putative ligand binding site [chemical binding]; other site 1142394001826 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1142394001827 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1142394001828 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1142394001829 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1142394001830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1142394001831 dimer interface [polypeptide binding]; other site 1142394001832 conserved gate region; other site 1142394001833 putative PBP binding loops; other site 1142394001834 ABC-ATPase subunit interface; other site 1142394001835 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1142394001836 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1142394001837 dimer interface [polypeptide binding]; other site 1142394001838 conserved gate region; other site 1142394001839 putative PBP binding loops; other site 1142394001840 ABC-ATPase subunit interface; other site 1142394001841 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1142394001842 EamA-like transporter family; Region: EamA; pfam00892 1142394001843 transaminase; Validated; Region: PRK07324 1142394001844 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1142394001845 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1142394001846 homodimer interface [polypeptide binding]; other site 1142394001847 catalytic residue [active] 1142394001848 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 1142394001849 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1142394001850 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1142394001851 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1142394001852 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 1142394001853 Fn3 associated; Region: Fn3_assoc; pfam13287 1142394001854 alpha-glucosidase; Provisional; Region: PRK10137 1142394001855 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1142394001856 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1142394001857 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1142394001858 Trehalase; Region: Trehalase; cl17346 1142394001859 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1142394001860 active site 1142394001861 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1142394001862 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1142394001863 Bacterial transcriptional regulator; Region: IclR; pfam01614 1142394001864 Saccharopine dehydrogenase and related proteins [Amino acid transport and metabolism]; Region: LYS9; COG1748 1142394001865 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1142394001866 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1142394001867 NAD(P) binding site [chemical binding]; other site 1142394001868 catalytic residues [active] 1142394001869 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1142394001870 extended (e) SDRs; Region: SDR_e; cd08946 1142394001871 NAD(P) binding site [chemical binding]; other site 1142394001872 active site 1142394001873 substrate binding site [chemical binding]; other site 1142394001874 Chitobiase/beta-hexosaminidase C-terminal domain; Region: CHB_HEX_C; pfam03174 1142394001875 N-terminal catalytic domain of mainly uncharacterized eukaryotic proteins similar to alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_like_1; cd10791 1142394001876 putative active site [active] 1142394001877 catalytic site [active] 1142394001878 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1142394001879 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 1142394001880 active site 1142394001881 Zn binding site [ion binding]; other site 1142394001882 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1142394001883 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1142394001884 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1142394001885 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1142394001886 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1142394001887 DNA interaction; other site 1142394001888 Metal-binding active site; metal-binding site 1142394001889 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 1142394001890 Fn3 associated; Region: Fn3_assoc; pfam13287 1142394001891 Fn3 associated; Region: Fn3_assoc; pfam13287 1142394001892 Domon-like ligand-binding domains; Region: DOMON_like; cl14783 1142394001893 putative ligand binding site [chemical binding]; other site 1142394001894 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 1142394001895 Queuine tRNA-ribosyltransferases, contain PUA domain [Translation, ribosomal structure and biogenesis]; Region: COG1549 1142394001896 Uncharacterized conserved protein [Function unknown]; Region: COG3379 1142394001897 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1142394001898 TPR motif; other site 1142394001899 binding surface 1142394001900 M42 glutamyl aminopeptidase; Region: Peptidase_M42; cl17262 1142394001901 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1142394001902 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1142394001903 putative substrate translocation pore; other site 1142394001904 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1142394001905 ornithine cyclodeaminase; Validated; Region: PRK06823; cl17400 1142394001906 ectoine utilization protein EutC; Validated; Region: PRK08291 1142394001907 transaminase; Validated; Region: PRK07324 1142394001908 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1142394001909 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1142394001910 homodimer interface [polypeptide binding]; other site 1142394001911 catalytic residue [active] 1142394001912 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 1142394001913 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 1142394001914 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1142394001915 active site 1142394001916 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1142394001917 IclR helix-turn-helix domain; Region: HTH_IclR; pfam09339 1142394001918 Bacterial transcriptional regulator; Region: IclR; pfam01614 1142394001919 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1142394001920 Strictosidine synthase; Region: Str_synth; pfam03088 1142394001921 Abhydrolase family; Region: Abhydrolase_7; pfam12715 1142394001922 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1142394001923 homotrimer interaction site [polypeptide binding]; other site 1142394001924 putative active site [active] 1142394001925 Demethylmenaquinone methyltransferase [Coenzyme metabolism]; Region: MenG; COG0684 1142394001926 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1142394001927 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1142394001928 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1142394001929 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1142394001930 DNA binding site [nucleotide binding] 1142394001931 domain linker motif; other site 1142394001932 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1142394001933 ligand binding site [chemical binding]; other site 1142394001934 Uncharacterized protein related to plant photosystem II stability/assembly factor [General function prediction only]; Region: COG4447 1142394001935 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 1142394001936 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 1142394001937 active site 1142394001938 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 1142394001939 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 1142394001940 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 1142394001941 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1142394001942 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1142394001943 DNA binding site [nucleotide binding] 1142394001944 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1142394001945 ligand binding site [chemical binding]; other site 1142394001946 dimerization interface [polypeptide binding]; other site 1142394001947 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 1142394001948 Alanine racemase [Cell envelope biogenesis, outer membrane]; Region: Alr; COG0787 1142394001949 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Alanine Racemase; Region: PLPDE_III_AR; cd00430 1142394001950 dimer interface [polypeptide binding]; other site 1142394001951 active site 1142394001952 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1142394001953 substrate binding site [chemical binding]; other site 1142394001954 catalytic residues [active] 1142394001955 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1142394001956 generic binding surface II; other site 1142394001957 generic binding surface I; other site 1142394001958 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 1142394001959 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1142394001960 Zn2+ binding site [ion binding]; other site 1142394001961 Mg2+ binding site [ion binding]; other site 1142394001962 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1142394001963 putative active site [active] 1142394001964 pyruvate phosphate dikinase; Provisional; Region: PRK09279 1142394001965 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1142394001966 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1142394001967 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1142394001968 Melibiase; Region: Melibiase; pfam02065 1142394001969 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1142394001970 Sulfatase; Region: Sulfatase; cl17466 1142394001971 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1142394001972 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1142394001973 DNA binding site [nucleotide binding] 1142394001974 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1142394001975 dimerization interface [polypeptide binding]; other site 1142394001976 ligand binding site [chemical binding]; other site 1142394001977 Sulfatase; Region: Sulfatase; cl17466 1142394001978 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1142394001979 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 1142394001980 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1142394001981 Sulfatase; Region: Sulfatase; pfam00884 1142394001982 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1142394001983 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1142394001984 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1142394001985 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1142394001986 DNA binding site [nucleotide binding] 1142394001987 domain linker motif; other site 1142394001988 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1142394001989 ligand binding site [chemical binding]; other site 1142394001990 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 1142394001991 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 1142394001992 endonuclease VIII; Provisional; Region: PRK10445 1142394001993 N-terminal domain of Fpg (formamidopyrimidine-DNA glycosylase, MutM)_Nei (endonuclease VIII) base-excision repair DNA glycosylases; Region: FpgNei_N; cl03119 1142394001994 DNA binding site [nucleotide binding] 1142394001995 H2TH interface [polypeptide binding]; other site 1142394001996 putative catalytic residues [active] 1142394001997 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1142394001998 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1142394001999 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 1142394002000 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1142394002001 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1142394002002 DNA binding site [nucleotide binding] 1142394002003 domain linker motif; other site 1142394002004 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1142394002005 dimerization interface [polypeptide binding]; other site 1142394002006 ligand binding site [chemical binding]; other site 1142394002007 TRAP transporter solute receptor, TAXI family; Region: TRAP_TAXI; TIGR02122 1142394002008 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1142394002009 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1142394002010 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1142394002011 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1142394002012 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1142394002013 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1142394002014 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1142394002015 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4587 1142394002016 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 1142394002017 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 1142394002018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1142394002019 Walker A/P-loop; other site 1142394002020 ATP binding site [chemical binding]; other site 1142394002021 Q-loop/lid; other site 1142394002022 ABC transporter signature motif; other site 1142394002023 Walker B; other site 1142394002024 D-loop; other site 1142394002025 H-loop/switch region; other site 1142394002026 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1142394002027 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1142394002028 DNA binding site [nucleotide binding] 1142394002029 domain linker motif; other site 1142394002030 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1142394002031 ligand binding site [chemical binding]; other site 1142394002032 dimerization interface [polypeptide binding]; other site 1142394002033 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1142394002034 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1142394002035 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1142394002036 BNR repeat-like domain; Region: BNR_2; pfam13088 1142394002037 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 1142394002038 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1142394002039 Periplasmic binding protein-like domain; Region: Peripla_BP_3; pfam13377 1142394002040 Endonuclease/Exonuclease/phosphatase family; Region: Exo_endo_phos; pfam03372 1142394002041 MFS/sugar transport protein; Region: MFS_2; pfam13347 1142394002042 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1142394002043 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 1142394002044 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1142394002045 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1142394002046 S-adenosylmethionine binding site [chemical binding]; other site 1142394002047 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1142394002048 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1142394002049 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1142394002050 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1142394002051 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 1142394002052 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 1142394002053 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1142394002054 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1142394002055 Cl- selectivity filter; other site 1142394002056 Cl- binding residues [ion binding]; other site 1142394002057 pore gating glutamate residue; other site 1142394002058 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1142394002059 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 1142394002060 dimer interface [polypeptide binding]; other site 1142394002061 FOG: CBS domain [General function prediction only]; Region: COG0517 1142394002062 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1142394002063 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1142394002064 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1142394002065 active site 1142394002066 metal binding site [ion binding]; metal-binding site 1142394002067 Anti-sigma-K factor rskA; Region: RskA; pfam10099 1142394002068 RNA polymerase sigma factor SigK; Reviewed; Region: PRK09646 1142394002069 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1142394002070 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1142394002071 DNA binding residues [nucleotide binding] 1142394002072 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1142394002073 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1142394002074 glutaminase active site [active] 1142394002075 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1142394002076 dimer interface [polypeptide binding]; other site 1142394002077 active site 1142394002078 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1142394002079 dimer interface [polypeptide binding]; other site 1142394002080 active site 1142394002081 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 1142394002082 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1142394002083 4Fe-4S binding domain; Region: Fer4; cl02805 1142394002084 4Fe-4S double cluster binding domain; Region: Fer4_16; pfam13484 1142394002085 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1142394002086 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1142394002087 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1142394002088 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1142394002089 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1142394002090 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 1142394002091 active site 1142394002092 DNA binding site [nucleotide binding] 1142394002093 Int/Topo IB signature motif; other site 1142394002094 thymidylate kinase; Validated; Region: tmk; PRK00698 1142394002095 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1142394002096 TMP-binding site; other site 1142394002097 ATP-binding site [chemical binding]; other site 1142394002098 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1142394002099 S-adenosylmethionine binding site [chemical binding]; other site 1142394002100 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1142394002101 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1142394002102 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1142394002103 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1142394002104 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1142394002105 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1142394002106 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1142394002107 N-terminal Early set domain associated with the catalytic domain of cellulase; Region: E_set_Cellulase_N; cd02850 1142394002108 Glycosyl hydrolase family 9; Region: Glyco_hydro_9; cl02959 1142394002109 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1142394002110 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1142394002111 active site 1142394002112 Thiamine pyrophosphate (TPP) family, E1 of PDC_ADC_BCADC subfamily, TPP-binding module; composed of proteins similar to the E1 components of the human pyruvate dehydrogenase complex (PDC), the acetoin dehydrogenase complex (ADC) and the branched chain...; Region: TPP_E1_PDC_ADC_BCADC; cd02000 1142394002113 tetramer interface [polypeptide binding]; other site 1142394002114 TPP-binding site [chemical binding]; other site 1142394002115 heterodimer interface [polypeptide binding]; other site 1142394002116 phosphorylation loop region [posttranslational modification] 1142394002117 Pyruvate/2-oxoglutarate dehydrogenase complex, dehydrogenase (E1) component, eukaryotic type, beta subunit [Energy production and conversion]; Region: AcoB; COG0022 1142394002118 Pyrimidine (PYR) binding domain of thiamine pyrophosphate (TPP)-dependent enzymes; Region: TPP_enzyme_PYR; cl11410 1142394002119 PYR/PP interface [polypeptide binding]; other site 1142394002120 dimer interface [polypeptide binding]; other site 1142394002121 TPP binding site [chemical binding]; other site 1142394002122 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1142394002123 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1142394002124 E3 interaction surface; other site 1142394002125 lipoyl attachment site [posttranslational modification]; other site 1142394002126 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK05963 1142394002127 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1142394002128 dimer interface [polypeptide binding]; other site 1142394002129 active site 1142394002130 CoA binding pocket [chemical binding]; other site 1142394002131 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1142394002132 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1142394002133 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1142394002134 flavoprotein, HI0933 family; Region: TIGR00275 1142394002135 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1142394002136 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1142394002137 putative active site [active] 1142394002138 catalytic triad [active] 1142394002139 putative dimer interface [polypeptide binding]; other site 1142394002140 HEAT repeats; Region: HEAT_2; pfam13646 1142394002141 HEAT repeats; Region: HEAT_2; pfam13646 1142394002142 HEAT repeats; Region: HEAT_2; pfam13646 1142394002143 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1142394002144 tRNA and rRNA cytosine-C5-methylases [Translation, ribosomal structure and biogenesis]; Region: Sun; COG0144 1142394002145 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1142394002146 S-adenosylmethionine binding site [chemical binding]; other site 1142394002147 Protein of unknown function (DUF3465); Region: DUF3465; pfam11948 1142394002148 phosphodiesterase; Provisional; Region: PRK12704 1142394002149 KH domain; Region: KH_1; pfam00013 1142394002150 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1142394002151 Zn2+ binding site [ion binding]; other site 1142394002152 Mg2+ binding site [ion binding]; other site 1142394002153 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1142394002154 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1142394002155 dimerization interface [polypeptide binding]; other site 1142394002156 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1142394002157 dimer interface [polypeptide binding]; other site 1142394002158 phosphorylation site [posttranslational modification] 1142394002159 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1142394002160 ATP binding site [chemical binding]; other site 1142394002161 Mg2+ binding site [ion binding]; other site 1142394002162 G-X-G motif; other site 1142394002163 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1142394002164 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1142394002165 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1142394002166 Dodecin; Region: Dodecin; pfam07311 1142394002167 Conserved domain frequently associated with peptide methionine sulfoxide reductase [Posttranslational modification, protein turnover, chaperones]; Region: COG0229 1142394002168 SelR domain; Region: SelR; pfam01641 1142394002169 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 1142394002170 Fasciclin domain; Region: Fasciclin; pfam02469 1142394002171 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1142394002172 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 1142394002173 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1142394002174 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1142394002175 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1142394002176 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1142394002177 NAD binding site [chemical binding]; other site 1142394002178 homodimer interface [polypeptide binding]; other site 1142394002179 active site 1142394002180 substrate binding site [chemical binding]; other site 1142394002181 Acetyl-CoA carboxylase beta subunit [Lipid metabolism]; Region: AccD; COG0777 1142394002182 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1142394002183 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1142394002184 active site 1142394002185 multimer interface [polypeptide binding]; other site 1142394002186 Uncharacterized conserved protein (DUF2203); Region: DUF2203; cl02056 1142394002187 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1142394002188 SNF2 Helicase protein; Region: DUF3670; pfam12419 1142394002189 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1142394002190 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1142394002191 putative Mg++ binding site [ion binding]; other site 1142394002192 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1142394002193 nucleotide binding region [chemical binding]; other site 1142394002194 ATP-binding site [chemical binding]; other site 1142394002195 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1142394002196 putative active site [active] 1142394002197 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 1142394002198 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1142394002199 ATP binding site [chemical binding]; other site 1142394002200 putative Mg++ binding site [ion binding]; other site 1142394002201 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1142394002202 nucleotide binding region [chemical binding]; other site 1142394002203 ATP-binding site [chemical binding]; other site 1142394002204 DEAD/H associated; Region: DEAD_assoc; pfam08494 1142394002205 ATP-dependent DNA ligase; Validated; Region: PRK09247 1142394002206 Adenylation domain of putative bacterial ATP-dependent DNA ligases; Region: Adenylation_DNA_ligase_Bac1; cd07897 1142394002207 active site 1142394002208 DNA binding site [nucleotide binding] 1142394002209 The Oligonucleotide/oligosaccharide binding (OB)-fold domain of archaeal and bacterial ATP-dependent DNA ligases is a DNA-binding module that is part of the catalytic core unit; Region: OBF_DNA_ligase_Arch_LigB; cd07972 1142394002210 DNA binding site [nucleotide binding] 1142394002211 Domain of unknown function (DUF897); Region: DUF897; cl01312 1142394002212 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 1142394002213 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1142394002214 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 1142394002215 putative hydrophobic ligand binding site [chemical binding]; other site 1142394002216 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1142394002217 active site 1142394002218 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 1142394002219 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1142394002220 TPR motif; other site 1142394002221 binding surface 1142394002222 Protein of unknown function (DUF3485); Region: DUF3485; cl11827 1142394002223 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 1142394002224 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 1142394002225 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1142394002226 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1142394002227 active site 1142394002228 HIGH motif; other site 1142394002229 nucleotide binding site [chemical binding]; other site 1142394002230 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1142394002231 active site 1142394002232 KMSKS motif; other site 1142394002233 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1142394002234 tRNA binding surface [nucleotide binding]; other site 1142394002235 anticodon binding site; other site 1142394002236 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1142394002237 Zn2+ binding site [ion binding]; other site 1142394002238 Mg2+ binding site [ion binding]; other site 1142394002239 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1142394002240 active site 1142394002241 Glucuronate isomerase; Region: UxaC; pfam02614 1142394002242 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1142394002243 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1142394002244 active site 1142394002245 ATP binding site [chemical binding]; other site 1142394002246 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1142394002247 substrate binding site [chemical binding]; other site 1142394002248 activation loop (A-loop); other site 1142394002249 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1142394002250 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1142394002251 FMN binding site [chemical binding]; other site 1142394002252 active site 1142394002253 catalytic residues [active] 1142394002254 substrate binding site [chemical binding]; other site 1142394002255 seryl-tRNA synthetase; Provisional; Region: PRK05431 1142394002256 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1142394002257 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1142394002258 motif 1; other site 1142394002259 dimer interface [polypeptide binding]; other site 1142394002260 active site 1142394002261 motif 2; other site 1142394002262 motif 3; other site 1142394002263 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 1142394002264 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1142394002265 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1142394002266 phenylhydantoinase; Validated; Region: PRK08323 1142394002267 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 1142394002268 tetramer interface [polypeptide binding]; other site 1142394002269 active site 1142394002270 Endonuclease I; Region: Endonuclease_1; cl01003 1142394002271 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1142394002272 active site 1142394002273 HIGH motif; other site 1142394002274 nucleotide binding site [chemical binding]; other site 1142394002275 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1142394002276 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1142394002277 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1142394002278 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1142394002279 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1142394002280 active site 1142394002281 KMSKS motif; other site 1142394002282 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1142394002283 tRNA binding surface [nucleotide binding]; other site 1142394002284 anticodon binding site; other site 1142394002285 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1142394002286 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1142394002287 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1142394002288 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1142394002289 Polysaccharide lyase; Region: Polysacc_lyase; pfam14099 1142394002290 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1142394002291 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1142394002292 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1142394002293 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1142394002294 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1142394002295 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1142394002296 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1142394002297 IMP binding site; other site 1142394002298 dimer interface [polypeptide binding]; other site 1142394002299 interdomain contacts; other site 1142394002300 partial ornithine binding site; other site 1142394002301 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 1142394002302 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1142394002303 ATP binding site [chemical binding]; other site 1142394002304 substrate interface [chemical binding]; other site 1142394002305 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1142394002306 ATP-grasp domain; Region: ATP-grasp; pfam02222 1142394002307 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 1142394002308 Flavoprotein; Region: Flavoprotein; pfam02441 1142394002309 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; cl14651 1142394002310 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1142394002311 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1142394002312 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1142394002313 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 1142394002314 active site 1142394002315 metal binding site [ion binding]; metal-binding site 1142394002316 Siroheme synthase (precorrin-2 oxidase/ferrochelatase domain) [Coenzyme metabolism]; Region: CysG; COG1648 1142394002317 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1142394002318 NAD(P) binding domain of amino acid dehydrogenase-like proteins; Region: NAD_bind_amino_acid_DH; cl17226 1142394002319 NAD(P) binding pocket [chemical binding]; other site 1142394002320 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1142394002321 ATP cone domain; Region: ATP-cone; pfam03477 1142394002322 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1142394002323 active site 1142394002324 metal binding site [ion binding]; metal-binding site 1142394002325 Predicted membrane protein [Function unknown]; Region: COG2323 1142394002326 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 1142394002327 adenylate kinase; Region: adk; TIGR01351 1142394002328 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1142394002329 AMP-binding site [chemical binding]; other site 1142394002330 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1142394002331 RmuC family; Region: RmuC; pfam02646 1142394002332 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1142394002333 Sulfatase; Region: Sulfatase; cl17466 1142394002334 Alpha-mannosidase [Carbohydrate transport and metabolism]; Region: AMS1; COG0383 1142394002335 N-terminal catalytic domain of endoplasmic reticulum(ER)/cytosolic class II alpha-mannosidases; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_ER_cytosolic; cd10789 1142394002336 active site 1142394002337 catalytic site [active] 1142394002338 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; cl08536 1142394002339 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1142394002340 Homeodomain-like domain; Region: HTH_23; cl17451 1142394002341 Winged helix-turn helix; Region: HTH_29; pfam13551 1142394002342 Homeodomain-like domain; Region: HTH_32; pfam13565 1142394002343 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1142394002344 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1142394002345 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1142394002346 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1142394002347 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1142394002348 classical (c) SDR, subgroup 3; Region: SDR_c3; cd05360 1142394002349 putative NAD(P) binding site [chemical binding]; other site 1142394002350 active site 1142394002351 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1142394002352 Sulfatase; Region: Sulfatase; cl17466 1142394002353 Sulfatase; Region: Sulfatase; cl17466 1142394002354 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1142394002355 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1142394002356 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1142394002357 DNA-binding site [nucleotide binding]; DNA binding site 1142394002358 FCD domain; Region: FCD; pfam07729 1142394002359 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1142394002360 Sulfatase; Region: Sulfatase; cl17466 1142394002361 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 1142394002362 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1142394002363 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1142394002364 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1142394002365 inhibitor site; inhibition site 1142394002366 active site 1142394002367 dimer interface [polypeptide binding]; other site 1142394002368 catalytic residue [active] 1142394002369 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 1142394002370 Na binding site [ion binding]; other site 1142394002371 Pentraxins are plasma proteins characterized by their pentameric discoid assembly and their Ca2+ dependent ligand binding, such as Serum amyloid P component (SAP) and C-reactive Protein (CRP), which are cytokine-inducible acute-phase proteins implicated...; Region: PTX; cl00102 1142394002372 Sulfatase; Region: Sulfatase; cl17466 1142394002373 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1142394002374 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1142394002375 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1142394002376 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1142394002377 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 1142394002378 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1142394002379 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1142394002380 DNA binding residues [nucleotide binding] 1142394002381 L,L-diaminopimelate aminotransferase; Validated; Region: PRK07590 1142394002382 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1142394002383 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1142394002384 homodimer interface [polypeptide binding]; other site 1142394002385 catalytic residue [active] 1142394002386 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1142394002387 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1142394002388 S-adenosylmethionine binding site [chemical binding]; other site 1142394002389 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 1142394002390 4Fe-4S binding domain; Region: Fer4; pfam00037 1142394002391 flavodoxin FldA; Validated; Region: PRK09267 1142394002392 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1142394002393 Pyrococcus furiosus PF1019 and related proteins, metallophosphatase domain; Region: MPP_PF1019; cd07391 1142394002394 putative active site [active] 1142394002395 putative metal binding site [ion binding]; other site 1142394002396 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 1142394002397 xylose isomerase; Provisional; Region: PRK05474 1142394002398 xylose isomerase; Region: xylose_isom_A; TIGR02630 1142394002399 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1142394002400 Ligand Binding Site [chemical binding]; other site 1142394002401 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1142394002402 Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad...; Region: Tryp_SPc; cl00149 1142394002403 active site 1142394002404 PEP-CTERM motif; Region: VPEP; pfam07589 1142394002405 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 1142394002406 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1142394002407 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1142394002408 GTPase CgtA; Reviewed; Region: obgE; PRK12299 1142394002409 GTP1/OBG; Region: GTP1_OBG; pfam01018 1142394002410 Obg GTPase; Region: Obg; cd01898 1142394002411 G1 box; other site 1142394002412 GTP/Mg2+ binding site [chemical binding]; other site 1142394002413 Switch I region; other site 1142394002414 G2 box; other site 1142394002415 G3 box; other site 1142394002416 Switch II region; other site 1142394002417 G4 box; other site 1142394002418 G5 box; other site 1142394002419 Type III pantothenate kinase; Region: Pan_kinase; cl17198 1142394002420 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1142394002421 G1 box; other site 1142394002422 GTP/Mg2+ binding site [chemical binding]; other site 1142394002423 G2 box; other site 1142394002424 Switch I region; other site 1142394002425 G3 box; other site 1142394002426 Switch II region; other site 1142394002427 G4 box; other site 1142394002428 G5 box; other site 1142394002429 hypothetical protein; Provisional; Region: PRK13665 1142394002430 Archaeal adenylate kinase [Nucleotide transport and metabolism]; Region: AdkA; cl17890 1142394002431 Isochorismatase family; Region: Isochorismatase; pfam00857 1142394002432 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1142394002433 catalytic triad [active] 1142394002434 conserved cis-peptide bond; other site 1142394002435 Alpha-L-arabinofuranosidase C-terminus; Region: Alpha-L-AF_C; cl01412 1142394002436 Uncharacterized protein family UPF0102; Region: UPF0102; cl00516 1142394002437 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1142394002438 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 1142394002439 Protein of unknown function (DUF3140); Region: DUF3140; pfam11338 1142394002440 putative hydrolase; Provisional; Region: PRK02113 1142394002441 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 1142394002442 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 1142394002443 Domain of unknown function DUF59; Region: DUF59; pfam01883 1142394002444 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Mrp; COG0489 1142394002445 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1142394002446 Walker A motif; other site 1142394002447 alanyl-tRNA synthetase; Region: PLN02900 1142394002448 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1142394002449 motif 1; other site 1142394002450 active site 1142394002451 motif 2; other site 1142394002452 motif 3; other site 1142394002453 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1142394002454 Chorismate mutase type II; Region: CM_2; cl00693 1142394002455 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 1142394002456 Prephenate dehydratase; Region: PDT; pfam00800 1142394002457 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1142394002458 putative L-Phe binding site [chemical binding]; other site 1142394002459 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982 1142394002460 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 1142394002461 NAD+ synthase (glutamine-hydrolysing); Region: PLN02339 1142394002462 multimer interface [polypeptide binding]; other site 1142394002463 active site 1142394002464 catalytic triad [active] 1142394002465 protein interface 1 [polypeptide binding]; other site 1142394002466 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1142394002467 Ligand Binding Site [chemical binding]; other site 1142394002468 Protein of unknown function DUF111; Region: DUF111; cl03398 1142394002469 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 1142394002470 Protein of unknown function DUF58; Region: DUF58; pfam01882 1142394002471 MoxR-like ATPases [General function prediction only]; Region: COG0714 1142394002472 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1142394002473 Walker A motif; other site 1142394002474 ATP binding site [chemical binding]; other site 1142394002475 Walker B motif; other site 1142394002476 arginine finger; other site 1142394002477 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1142394002478 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1142394002479 Walker A/P-loop; other site 1142394002480 ATP binding site [chemical binding]; other site 1142394002481 Q-loop/lid; other site 1142394002482 ABC transporter signature motif; other site 1142394002483 Walker B; other site 1142394002484 D-loop; other site 1142394002485 H-loop/switch region; other site 1142394002486 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1142394002487 dimer interface [polypeptide binding]; other site 1142394002488 conserved gate region; other site 1142394002489 putative PBP binding loops; other site 1142394002490 ABC-ATPase subunit interface; other site 1142394002491 Bacterial extracellular solute-binding proteins, family 3; Region: SBP_bac_3; pfam00497 1142394002492 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1142394002493 substrate binding pocket [chemical binding]; other site 1142394002494 membrane-bound complex binding site; other site 1142394002495 hinge residues; other site 1142394002496 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1142394002497 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1142394002498 Urease accessory protein UreF [Posttranslational modification, protein turnover, chaperones]; Region: UreF; COG0830 1142394002499 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1142394002500 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1142394002501 putative ligand binding site [chemical binding]; other site 1142394002502 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1142394002503 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1142394002504 TM-ABC transporter signature motif; other site 1142394002505 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 1142394002506 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1142394002507 TM-ABC transporter signature motif; other site 1142394002508 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1142394002509 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1142394002510 Walker A/P-loop; other site 1142394002511 ATP binding site [chemical binding]; other site 1142394002512 Q-loop/lid; other site 1142394002513 ABC transporter signature motif; other site 1142394002514 Walker B; other site 1142394002515 D-loop; other site 1142394002516 H-loop/switch region; other site 1142394002517 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1142394002518 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1142394002519 Walker A/P-loop; other site 1142394002520 ATP binding site [chemical binding]; other site 1142394002521 Q-loop/lid; other site 1142394002522 ABC transporter signature motif; other site 1142394002523 Walker B; other site 1142394002524 D-loop; other site 1142394002525 H-loop/switch region; other site 1142394002526 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1142394002527 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cl01898 1142394002528 putative active site [active] 1142394002529 UreD urease accessory protein; Region: UreD; pfam01774 1142394002530 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1142394002531 Cupin domain; Region: Cupin_2; cl17218 1142394002532 Helix-turn-helix domain; Region: HTH_18; pfam12833 1142394002533 bifunctional urease subunit gamma/beta; Reviewed; Region: PRK13192 1142394002534 Urease gamma-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use...; Region: Urease_gamma; cd00390 1142394002535 alpha-gamma subunit interface [polypeptide binding]; other site 1142394002536 beta-gamma subunit interface [polypeptide binding]; other site 1142394002537 Urease beta-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, archaea, fungi and plants. Their primary role is to allow the use of...; Region: Urease_beta; cd00407 1142394002538 alpha-beta subunit interface [polypeptide binding]; other site 1142394002539 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1142394002540 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 1142394002541 nucleotide binding site [chemical binding]; other site 1142394002542 NEF interaction site [polypeptide binding]; other site 1142394002543 SBD interface [polypeptide binding]; other site 1142394002544 DNA repair protein RadA; Provisional; Region: PRK11823 1142394002545 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1142394002546 Walker A motif; other site 1142394002547 ATP binding site [chemical binding]; other site 1142394002548 Walker B motif; other site 1142394002549 Uncharacterized conserved protein [Function unknown]; Region: COG4850 1142394002550 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 1142394002551 glycyl-tRNA synthetase; Provisional; Region: PRK04173 1142394002552 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1142394002553 motif 1; other site 1142394002554 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 1142394002555 dimer interface [polypeptide binding]; other site 1142394002556 active site 1142394002557 motif 2; other site 1142394002558 motif 3; other site 1142394002559 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 1142394002560 anticodon binding site; other site 1142394002561 Protein of unknown function, DUF547; Region: DUF547; pfam04784 1142394002562 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 1142394002563 sequence-specific DNA binding site [nucleotide binding]; other site 1142394002564 salt bridge; other site 1142394002565 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1142394002566 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1142394002567 MraW methylase family; Region: Methyltransf_5; cl17771 1142394002568 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1142394002569 active site 1142394002570 dimer interface [polypeptide binding]; other site 1142394002571 lipoprotein releasing system, ATP-binding protein; Region: LolD_lipo_ex; TIGR02211 1142394002572 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1142394002573 Walker A/P-loop; other site 1142394002574 ATP binding site [chemical binding]; other site 1142394002575 Q-loop/lid; other site 1142394002576 ABC transporter signature motif; other site 1142394002577 Walker B; other site 1142394002578 D-loop; other site 1142394002579 H-loop/switch region; other site 1142394002580 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1142394002581 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 1142394002582 lipoprotein releasing system, transmembrane protein, LolC/E family; Region: lolCE; TIGR02212 1142394002583 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1142394002584 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1142394002585 dimer interface [polypeptide binding]; other site 1142394002586 putative anticodon binding site; other site 1142394002587 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1142394002588 motif 1; other site 1142394002589 active site 1142394002590 motif 2; other site 1142394002591 motif 3; other site 1142394002592 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1142394002593 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1142394002594 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1142394002595 NAD(P) binding site [chemical binding]; other site 1142394002596 active site 1142394002597 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1142394002598 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1142394002599 ATP binding site [chemical binding]; other site 1142394002600 Mg++ binding site [ion binding]; other site 1142394002601 motif III; other site 1142394002602 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1142394002603 nucleotide binding region [chemical binding]; other site 1142394002604 ATP-binding site [chemical binding]; other site 1142394002605 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1142394002606 anti sigma factor interaction site; other site 1142394002607 regulatory phosphorylation site [posttranslational modification]; other site 1142394002608 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 1142394002609 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1142394002610 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1142394002611 Phosphoglycerate kinase; Region: PGK; pfam00162 1142394002612 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1142394002613 substrate binding site [chemical binding]; other site 1142394002614 hinge regions; other site 1142394002615 ADP binding site [chemical binding]; other site 1142394002616 catalytic site [active] 1142394002617 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1142394002618 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1142394002619 Magnesium ion binding site [ion binding]; other site 1142394002620 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1142394002621 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1142394002622 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1142394002623 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1142394002624 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1142394002625 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 1142394002626 Glutamate dehydrogenase/leucine dehydrogenase [Amino acid transport and metabolism]; Region: GdhA; COG0334 1142394002627 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1142394002628 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 1142394002629 NAD(P) binding site [chemical binding]; other site 1142394002630 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1142394002631 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1142394002632 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1142394002633 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1142394002634 active site 1142394002635 branched-chain alpha-keto acid dehydrogenase subunit E2; Reviewed; Region: PRK11856 1142394002636 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1142394002637 E3 interaction surface; other site 1142394002638 lipoyl attachment site [posttranslational modification]; other site 1142394002639 e3 binding domain; Region: E3_binding; pfam02817 1142394002640 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1142394002641 Protein of unknown function (DUF421); Region: DUF421; pfam04239 1142394002642 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1142394002643 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1142394002644 active site 1142394002645 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1142394002646 catalytic tetrad [active] 1142394002647 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1142394002648 substrate binding site; other site 1142394002649 dimer interface; other site 1142394002650 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1142394002651 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1142394002652 TPR motif; other site 1142394002653 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1142394002654 Nif-specific regulatory protein; Region: nifA; TIGR01817 1142394002655 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1142394002656 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1142394002657 Walker A motif; other site 1142394002658 ATP binding site [chemical binding]; other site 1142394002659 Walker B motif; other site 1142394002660 arginine finger; other site 1142394002661 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1142394002662 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1142394002663 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1142394002664 oligomer interface [polypeptide binding]; other site 1142394002665 active site 1142394002666 metal binding site [ion binding]; metal-binding site 1142394002667 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1142394002668 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1142394002669 Coenzyme A binding pocket [chemical binding]; other site 1142394002670 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1142394002671 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1142394002672 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1142394002673 glucosamine-6-phosphate deaminase-like protein; Validated; Region: PRK02122 1142394002674 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1142394002675 active site 1142394002676 trimer interface [polypeptide binding]; other site 1142394002677 allosteric site; other site 1142394002678 active site lid [active] 1142394002679 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1142394002680 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 1142394002681 Heparinase II/III-like protein; Region: Hepar_II_III; pfam07940 1142394002682 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1142394002683 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1142394002684 amidase catalytic site [active] 1142394002685 Zn binding residues [ion binding]; other site 1142394002686 substrate binding site [chemical binding]; other site 1142394002687 Stage II sporulation protein; Region: SpoIID; pfam08486 1142394002688 stage II sporulation protein D; Region: spore_II_D; TIGR02870 1142394002689 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1142394002690 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1142394002691 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1142394002692 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1142394002693 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1142394002694 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1142394002695 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1142394002696 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1142394002697 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1142394002698 DNA-binding site [nucleotide binding]; DNA binding site 1142394002699 D-fructose-responsive transcription factor; Region: fruct_sucro_rep; TIGR02417 1142394002700 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1142394002701 ligand binding site [chemical binding]; other site 1142394002702 dimerization interface [polypeptide binding]; other site 1142394002703 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 1142394002704 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1142394002705 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1142394002706 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1142394002707 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1142394002708 dimer interface [polypeptide binding]; other site 1142394002709 putative PBP binding loops; other site 1142394002710 ABC-ATPase subunit interface; other site 1142394002711 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1142394002712 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1142394002713 dimer interface [polypeptide binding]; other site 1142394002714 conserved gate region; other site 1142394002715 ABC-ATPase subunit interface; other site 1142394002716 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cd00599 1142394002717 Glycosyl hydrolases family 25; Region: Glyco_hydro_25; pfam01183 1142394002718 active site 1142394002719 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1142394002720 substrate binding site [chemical binding]; other site 1142394002721 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cl02712 1142394002722 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1142394002723 nucleotide sugar dehydrogenase; Region: NDP-sugDHase; TIGR03026 1142394002724 D-alanyl-D-alanine carboxypeptidase; Region: VanY; pfam02557 1142394002725 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1142394002726 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1142394002727 Metal-binding active site; metal-binding site 1142394002728 replicative DNA helicase; Region: DnaB; TIGR00665 1142394002729 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1142394002730 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1142394002731 Walker A motif; other site 1142394002732 ATP binding site [chemical binding]; other site 1142394002733 Walker B motif; other site 1142394002734 DNA binding loops [nucleotide binding] 1142394002735 Queuosine biosynthesis protein; Region: Queuosine_synth; cl00523 1142394002736 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1142394002737 Predicted double-stranded RNA/RNA-DNA hybrid binding protein [General function prediction only]; Region: COG3341 1142394002738 Caulimovirus viroplasmin; Region: Cauli_VI; pfam01693 1142394002739 tRNA threonylcarbamoyl adenosine modification protein YgjD; Region: T6A_YgjD; TIGR03723 1142394002740 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1142394002741 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 1142394002742 C-terminal peptidase (prc); Region: prc; TIGR00225 1142394002743 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1142394002744 protein binding site [polypeptide binding]; other site 1142394002745 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1142394002746 Catalytic dyad [active] 1142394002747 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 1142394002748 Cupin domain; Region: Cupin_2; pfam07883 1142394002749 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1142394002750 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1142394002751 Domain of unknown function (DUF427); Region: DUF427; pfam04248 1142394002752 glutamine synthetase, type III; Region: gln_synth_III; TIGR03105 1142394002753 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1142394002754 Creatinine amidohydrolase; Region: Creatininase; pfam02633 1142394002755 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1142394002756 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1142394002757 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1142394002758 [2Fe-2S] cluster binding site [ion binding]; other site 1142394002759 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 1142394002760 hydrophobic ligand binding site; other site 1142394002761 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1142394002762 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1142394002763 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1142394002764 ABC transporter periplasmic binding protein, urea carboxylase region; Region: ABC_peri_uca; TIGR03427 1142394002765 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1142394002766 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1142394002767 dimer interface [polypeptide binding]; other site 1142394002768 conserved gate region; other site 1142394002769 putative PBP binding loops; other site 1142394002770 ABC-ATPase subunit interface; other site 1142394002771 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1142394002772 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1142394002773 Walker A/P-loop; other site 1142394002774 ATP binding site [chemical binding]; other site 1142394002775 Q-loop/lid; other site 1142394002776 ABC transporter signature motif; other site 1142394002777 Walker B; other site 1142394002778 D-loop; other site 1142394002779 H-loop/switch region; other site 1142394002780 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1142394002781 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1142394002782 agmatinase; Region: agmatinase; TIGR01230 1142394002783 Agmatinase-like family; Region: Agmatinase-like; cd09990 1142394002784 active site 1142394002785 oligomer interface [polypeptide binding]; other site 1142394002786 Mn binding site [ion binding]; other site 1142394002787 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 1142394002788 Hydrogenase expression/synthesis hypA family; Region: HypA; pfam01155 1142394002789 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1142394002790 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1142394002791 Rhodanese Homology Domain; Region: RHOD; smart00450 1142394002792 active site residue [active] 1142394002793 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 1142394002794 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 1142394002795 Glycoside hydrolase family 15, N-terminal domain; Region: GH15_N; cd07430 1142394002796 Domain interface; other site 1142394002797 glucan 1,4-alpha-glucosidase; Region: glucan_glucosid; TIGR01535 1142394002798 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1142394002799 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 1142394002800 putative active site [active] 1142394002801 coproporphyrinogen III oxidase; Validated; Region: PRK05628 1142394002802 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1142394002803 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1142394002804 phosphopeptide binding site; other site 1142394002805 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 1142394002806 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3323 1142394002807 NIF3 (NGG1p interacting factor 3); Region: NIF3; cl15371 1142394002808 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1142394002809 catalytic center binding site [active] 1142394002810 ATP binding site [chemical binding]; other site 1142394002811 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 1142394002812 TPR repeat; Region: TPR_11; pfam13414 1142394002813 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1142394002814 binding surface 1142394002815 TPR motif; other site 1142394002816 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1142394002817 TPR motif; other site 1142394002818 binding surface 1142394002819 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 1142394002820 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 1142394002821 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1142394002822 Ligand Binding Site [chemical binding]; other site 1142394002823 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 1142394002824 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1142394002825 Walker A/P-loop; other site 1142394002826 ATP binding site [chemical binding]; other site 1142394002827 Q-loop/lid; other site 1142394002828 ABC transporter signature motif; other site 1142394002829 Walker B; other site 1142394002830 D-loop; other site 1142394002831 H-loop/switch region; other site 1142394002832 alpha-glucosidase; Provisional; Region: PRK10137 1142394002833 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 1142394002834 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1142394002835 active site 1142394002836 phosphorylation site [posttranslational modification] 1142394002837 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 1142394002838 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1142394002839 ATP binding site [chemical binding]; other site 1142394002840 putative Mg++ binding site [ion binding]; other site 1142394002841 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1142394002842 nucleotide binding region [chemical binding]; other site 1142394002843 ATP-binding site [chemical binding]; other site 1142394002844 RQC domain; Region: RQC; pfam09382 1142394002845 HRDC domain; Region: HRDC; pfam00570 1142394002846 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 1142394002847 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 1142394002848 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1142394002849 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1142394002850 active site 1142394002851 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1142394002852 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1142394002853 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1142394002854 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1142394002855 active site 1142394002856 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1142394002857 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1142394002858 active site 1142394002859 Protein of unknown function (DUF563); Region: DUF563; pfam04577 1142394002860 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1142394002861 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 1142394002862 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1142394002863 Walker A/P-loop; other site 1142394002864 ATP binding site [chemical binding]; other site 1142394002865 Q-loop/lid; other site 1142394002866 ABC transporter signature motif; other site 1142394002867 Walker B; other site 1142394002868 D-loop; other site 1142394002869 H-loop/switch region; other site 1142394002870 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1142394002871 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1142394002872 PAS fold; Region: PAS_3; pfam08447 1142394002873 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1142394002874 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1142394002875 ATP binding site [chemical binding]; other site 1142394002876 Mg2+ binding site [ion binding]; other site 1142394002877 G-X-G motif; other site 1142394002878 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1142394002879 FAD binding site [chemical binding]; other site 1142394002880 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1142394002881 IHF - DNA interface [nucleotide binding]; other site 1142394002882 IHF dimer interface [polypeptide binding]; other site 1142394002883 urease subunit alpha; Reviewed; Region: ureC; PRK13207 1142394002884 Urease alpha-subunit; Urease is a nickel-dependent metalloenzyme that catalyzes the hydrolysis of urea to form ammonia and carbon dioxide. Nickel-dependent ureases are found in bacteria, fungi and plants. Their primary role is to allow the use of...; Region: Urease_alpha; cd00375 1142394002885 subunit interactions [polypeptide binding]; other site 1142394002886 active site 1142394002887 flap region; other site 1142394002888 Monomeric isocitrate dehydrogenase [Energy production and conversion]; Region: Icd; COG2838 1142394002889 Monomeric isocitrate dehydrogenase; Region: IDH; cl15383 1142394002890 Autotransporter beta-domain; Region: Autotransporter; smart00869 1142394002891 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 1142394002892 active site 1142394002893 catalytic residues [active] 1142394002894 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1142394002895 ATP-binding cassette domain of the lipid transporters, subfamily A; Region: ABC_subfamily_A; cd03263 1142394002896 Walker A/P-loop; other site 1142394002897 ATP binding site [chemical binding]; other site 1142394002898 Q-loop/lid; other site 1142394002899 ABC transporter signature motif; other site 1142394002900 Walker B; other site 1142394002901 D-loop; other site 1142394002902 H-loop/switch region; other site 1142394002903 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 1142394002904 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 1142394002905 transcription termination factor NusA; Region: NusA; TIGR01953 1142394002906 NusA N-terminal domain; Region: NusA_N; pfam08529 1142394002907 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1142394002908 RNA binding site [nucleotide binding]; other site 1142394002909 homodimer interface [polypeptide binding]; other site 1142394002910 NusA-like KH domain; Region: KH_5; pfam13184 1142394002911 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1142394002912 G-X-X-G motif; other site 1142394002913 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1142394002914 translation initiation factor IF-2; Region: IF-2; TIGR00487 1142394002915 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1142394002916 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1142394002917 G1 box; other site 1142394002918 putative GEF interaction site [polypeptide binding]; other site 1142394002919 GTP/Mg2+ binding site [chemical binding]; other site 1142394002920 Switch I region; other site 1142394002921 G2 box; other site 1142394002922 G3 box; other site 1142394002923 Switch II region; other site 1142394002924 G4 box; other site 1142394002925 G5 box; other site 1142394002926 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1142394002927 Translation-initiation factor 2; Region: IF-2; pfam11987 1142394002928 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1142394002929 Uncharacterized protein, 4-oxalocrotonate tautomerase homolog [General function prediction only]; Region: COG1942 1142394002930 active site 1 [active] 1142394002931 dimer interface [polypeptide binding]; other site 1142394002932 hexamer interface [polypeptide binding]; other site 1142394002933 active site 2 [active] 1142394002934 Ribosome-binding factor A; Region: RBFA; pfam02033 1142394002935 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1142394002936 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1142394002937 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1142394002938 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1142394002939 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 1142394002940 hinge; other site 1142394002941 active site 1142394002942 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1142394002943 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 1142394002944 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 1142394002945 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1142394002946 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1142394002947 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 1142394002948 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1142394002949 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1142394002950 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1142394002951 active site 1142394002952 HIGH motif; other site 1142394002953 dimer interface [polypeptide binding]; other site 1142394002954 KMSKS motif; other site 1142394002955 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1142394002956 RNA binding surface [nucleotide binding]; other site 1142394002957 Protein of unknown function, DUF393; Region: DUF393; pfam04134 1142394002958 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1142394002959 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1142394002960 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1142394002961 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1142394002962 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1142394002963 23S rRNA interface [nucleotide binding]; other site 1142394002964 L3 interface [polypeptide binding]; other site 1142394002965 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1142394002966 o-succinylbenzoate synthase; Region: menC_lowGC/arch; TIGR01928 1142394002967 active site 1142394002968 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 1142394002969 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 1142394002970 CrcB-like protein; Region: CRCB; cl09114 1142394002971 SurA N-terminal domain; Region: SurA_N_3; cl07813 1142394002972 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1142394002973 ThiS interaction site; other site 1142394002974 putative active site [active] 1142394002975 tetramer interface [polypeptide binding]; other site 1142394002976 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1142394002977 thiS-thiF/thiG interaction site; other site 1142394002978 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1142394002979 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1142394002980 S-adenosylmethionine binding site [chemical binding]; other site 1142394002981 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1142394002982 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1142394002983 folate binding site [chemical binding]; other site 1142394002984 NADP+ binding site [chemical binding]; other site 1142394002985 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 1142394002986 hypothetical protein; Provisional; Region: PRK08609 1142394002987 active site 1142394002988 primer binding site [nucleotide binding]; other site 1142394002989 NTP binding site [chemical binding]; other site 1142394002990 metal binding triad [ion binding]; metal-binding site 1142394002991 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 1142394002992 active site 1142394002993 Protein of unknown function (DUF721); Region: DUF721; pfam05258 1142394002994 shikimate kinase; Reviewed; Region: aroK; PRK00131 1142394002995 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1142394002996 active site 1142394002997 ribonuclease R; Region: RNase_R; TIGR02063 1142394002998 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1142394002999 RNB domain; Region: RNB; pfam00773 1142394003000 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1142394003001 RNA binding site [nucleotide binding]; other site 1142394003002 Protein of unknown function (DUF964); Region: DUF964; pfam06133 1142394003003 HEAT repeats; Region: HEAT_2; pfam13646 1142394003004 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1142394003005 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1142394003006 putative active site [active] 1142394003007 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 1142394003008 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1142394003009 active site 1142394003010 metal binding site [ion binding]; metal-binding site 1142394003011 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1142394003012 nudix motif; other site 1142394003013 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 1142394003014 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1142394003015 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1142394003016 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1142394003017 binding surface 1142394003018 TPR motif; other site 1142394003019 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1142394003020 binding surface 1142394003021 TPR motif; other site 1142394003022 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1142394003023 TPR motif; other site 1142394003024 binding surface 1142394003025 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1142394003026 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1142394003027 Zn2+ binding site [ion binding]; other site 1142394003028 Mg2+ binding site [ion binding]; other site 1142394003029 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1142394003030 serine/threonine protein kinase; Provisional; Region: PRK12274 1142394003031 TrkA-N domain; Region: TrkA_N; pfam02254 1142394003032 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 1142394003033 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 1142394003034 ATP-NAD kinase; Region: NAD_kinase; pfam01513 1142394003035 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1142394003036 Domain of unknown function DUF21; Region: DUF21; pfam01595 1142394003037 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1142394003038 Transporter associated domain; Region: CorC_HlyC; smart01091 1142394003039 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 1142394003040 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 1142394003041 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1142394003042 Mg2+ binding site [ion binding]; other site 1142394003043 G-X-G motif; other site 1142394003044 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1142394003045 anti sigma factor interaction site; other site 1142394003046 regulatory phosphorylation site [posttranslational modification]; other site 1142394003047 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1142394003048 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1142394003049 rod shape-determining protein MreB; Provisional; Region: PRK13927 1142394003050 MreB and similar proteins; Region: MreB_like; cd10225 1142394003051 nucleotide binding site [chemical binding]; other site 1142394003052 Mg binding site [ion binding]; other site 1142394003053 putative protofilament interaction site [polypeptide binding]; other site 1142394003054 RodZ interaction site [polypeptide binding]; other site 1142394003055 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1142394003056 Homeodomain-like domain; Region: HTH_23; cl17451 1142394003057 Winged helix-turn helix; Region: HTH_29; pfam13551 1142394003058 Homeodomain-like domain; Region: HTH_32; pfam13565 1142394003059 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1142394003060 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 1142394003061 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1142394003062 B12 binding site [chemical binding]; other site 1142394003063 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1142394003064 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1142394003065 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 1142394003066 Methionine synthase I, cobalamin-binding domain [Amino acid transport and metabolism]; Region: MetH; COG1410 1142394003067 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 1142394003068 substrate binding pocket [chemical binding]; other site 1142394003069 dimer interface [polypeptide binding]; other site 1142394003070 inhibitor binding site; inhibition site 1142394003071 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1142394003072 A/G-specific adenine glycosylase; Region: mutY; TIGR01084 1142394003073 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1142394003074 minor groove reading motif; other site 1142394003075 helix-hairpin-helix signature motif; other site 1142394003076 substrate binding pocket [chemical binding]; other site 1142394003077 active site 1142394003078 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1142394003079 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1142394003080 DNA binding and oxoG recognition site [nucleotide binding] 1142394003081 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; cl01093 1142394003082 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1142394003083 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1142394003084 Walker A motif; other site 1142394003085 ATP binding site [chemical binding]; other site 1142394003086 Walker B motif; other site 1142394003087 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1142394003088 Walker A motif; other site 1142394003089 ATP binding site [chemical binding]; other site 1142394003090 Walker B motif; other site 1142394003091 UDP-N-acetylmuramoylalanine--D-glutamate ligase; Region: murD; TIGR01087 1142394003092 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1142394003093 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1142394003094 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1142394003095 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1142394003096 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1142394003097 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 1142394003098 feedback inhibition sensing region; other site 1142394003099 homohexameric interface [polypeptide binding]; other site 1142394003100 nucleotide binding site [chemical binding]; other site 1142394003101 N-acetyl-L-glutamate binding site [chemical binding]; other site 1142394003102 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1142394003103 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1142394003104 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1142394003105 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1142394003106 Walker A/P-loop; other site 1142394003107 ATP binding site [chemical binding]; other site 1142394003108 Q-loop/lid; other site 1142394003109 ABC transporter signature motif; other site 1142394003110 Walker B; other site 1142394003111 D-loop; other site 1142394003112 H-loop/switch region; other site 1142394003113 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1142394003114 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1142394003115 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1142394003116 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1142394003117 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1142394003118 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1142394003119 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1142394003120 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1142394003121 putative acyl-acceptor binding pocket; other site 1142394003122 Short C-terminal domain; Region: SHOCT; pfam09851 1142394003123 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1142394003124 Radical SAM superfamily; Region: Radical_SAM; pfam04055 1142394003125 FeS/SAM binding site; other site 1142394003126 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1142394003127 Ubiquitin-like proteins; Region: UBQ; cl00155 1142394003128 charged pocket; other site 1142394003129 hydrophobic patch; other site 1142394003130 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cl00399 1142394003131 MoaE homodimer interface [polypeptide binding]; other site 1142394003132 MoaD interaction [polypeptide binding]; other site 1142394003133 active site residues [active] 1142394003134 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1142394003135 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 1142394003136 dimer interface [polypeptide binding]; other site 1142394003137 putative functional site; other site 1142394003138 putative MPT binding site; other site 1142394003139 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 1142394003140 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 1142394003141 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 1142394003142 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1142394003143 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1142394003144 active site 1142394003145 catalytic tetrad [active] 1142394003146 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1142394003147 HlyD family secretion protein; Region: HlyD_3; pfam13437 1142394003148 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1142394003149 HlyD family secretion protein; Region: HlyD_3; pfam13437 1142394003150 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1142394003151 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1142394003152 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1142394003153 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1142394003154 gamma-glutamyl kinase; Provisional; Region: PRK05429 1142394003155 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1142394003156 nucleotide binding site [chemical binding]; other site 1142394003157 homotetrameric interface [polypeptide binding]; other site 1142394003158 putative phosphate binding site [ion binding]; other site 1142394003159 putative allosteric binding site; other site 1142394003160 PUA domain; Region: PUA; cl00607 1142394003161 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1142394003162 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1142394003163 MGS-like domain. This domain composes the whole protein of methylglyoxal synthetase, which catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The family also includes the C-terminal domain in carbamoyl phosphate...; Region: MGS-like; cl00245 1142394003164 substrate binding site [chemical binding]; other site 1142394003165 hypothetical protein; Validated; Region: PRK06886 1142394003166 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1142394003167 active site 1142394003168 Ion channel; Region: Ion_trans_2; pfam07885 1142394003169 Glycerol-3-phosphate acyltransferase; Region: G3P_acyltransf; cl00410 1142394003170 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1142394003171 phosphoglyceromutase; Provisional; Region: PRK05434 1142394003172 Phosphoglyceromutase [Carbohydrate transport and metabolism]; Region: GpmI; COG0696 1142394003173 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1142394003174 active site 1142394003175 Glycosyl transferase family 21; Region: Glyco_transf_21; pfam13506 1142394003176 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1142394003177 HlyD family secretion protein; Region: HlyD_3; pfam13437 1142394003178 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 1142394003179 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 1142394003180 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1142394003181 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 1142394003182 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; cl00311 1142394003183 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 1142394003184 active site 1142394003185 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 1142394003186 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1142394003187 substrate binding site [chemical binding]; other site 1142394003188 trimer interface [polypeptide binding]; other site 1142394003189 Mn binding site [ion binding]; other site 1142394003190 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1142394003191 N- and C-terminal domain interface [polypeptide binding]; other site 1142394003192 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 1142394003193 active site 1142394003194 putative catalytic site [active] 1142394003195 metal binding site [ion binding]; metal-binding site 1142394003196 ATP binding site [chemical binding]; other site 1142394003197 carbohydrate binding site [chemical binding]; other site 1142394003198 Uncharacterized conserved protein [Function unknown]; Region: COG3347 1142394003199 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 1142394003200 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1142394003201 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1142394003202 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1142394003203 methionyl-tRNA synthetase; Reviewed; Region: PRK11893 1142394003204 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1142394003205 active site 1142394003206 HIGH motif; other site 1142394003207 KMSKS motif; other site 1142394003208 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1142394003209 tRNA binding surface [nucleotide binding]; other site 1142394003210 anticodon binding site; other site 1142394003211 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1142394003212 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1142394003213 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1142394003214 metal binding site [ion binding]; metal-binding site 1142394003215 active site 1142394003216 I-site; other site 1142394003217 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1142394003218 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 1142394003219 putative metal binding site [ion binding]; other site 1142394003220 Glycosyl hydrolase family 26; Region: Glyco_hydro_26; pfam02156 1142394003221 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 1142394003222 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1142394003223 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1142394003224 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1142394003225 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1142394003226 Class II fumarases; Region: Fumarase_classII; cd01362 1142394003227 active site 1142394003228 tetramer interface [polypeptide binding]; other site 1142394003229 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK14192 1142394003230 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1142394003231 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1142394003232 homodimer interface [polypeptide binding]; other site 1142394003233 NADP binding site [chemical binding]; other site 1142394003234 substrate binding site [chemical binding]; other site 1142394003235 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1142394003236 protein binding site [polypeptide binding]; other site 1142394003237 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1142394003238 Catalytic dyad [active] 1142394003239 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1142394003240 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1142394003241 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1142394003242 Walker A motif; other site 1142394003243 ATP binding site [chemical binding]; other site 1142394003244 Walker B motif; other site 1142394003245 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1142394003246 trigger factor; Region: tig; TIGR00115 1142394003247 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1142394003248 Predicted membrane protein [Function unknown]; Region: COG4325 1142394003249 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 1142394003250 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 1142394003251 Uncharacterized conserved protein (DUF2156); Region: DUF2156; cl12090 1142394003252 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 1142394003253 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1142394003254 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1142394003255 G1 box; other site 1142394003256 GTP/Mg2+ binding site [chemical binding]; other site 1142394003257 G2 box; other site 1142394003258 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1142394003259 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1142394003260 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 1142394003261 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 1142394003262 active site 1142394003263 catalytic triad [active] 1142394003264 oxyanion hole [active] 1142394003265 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1142394003266 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1142394003267 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1142394003268 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1142394003269 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1142394003270 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1142394003271 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1142394003272 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1142394003273 NADH dehydrogenase subunit 6; Provisional; Region: ND6; MTH00213 1142394003274 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1142394003275 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1142394003276 putative PBP binding regions; other site 1142394003277 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 1142394003278 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1142394003279 Walker A/P-loop; other site 1142394003280 ATP binding site [chemical binding]; other site 1142394003281 Q-loop/lid; other site 1142394003282 ABC transporter signature motif; other site 1142394003283 Walker B; other site 1142394003284 D-loop; other site 1142394003285 H-loop/switch region; other site 1142394003286 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 1142394003287 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 1142394003288 intersubunit interface [polypeptide binding]; other site 1142394003289 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1142394003290 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1142394003291 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1142394003292 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1142394003293 HflC protein; Region: hflC; TIGR01932 1142394003294 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1142394003295 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1142394003296 The band 7 domain of flotillin (reggie) like proteins. This group contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual proteins of this...; Region: Band_7; cl02525 1142394003297 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1142394003298 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1142394003299 Walker A/P-loop; other site 1142394003300 ATP binding site [chemical binding]; other site 1142394003301 Q-loop/lid; other site 1142394003302 ABC transporter signature motif; other site 1142394003303 Walker B; other site 1142394003304 D-loop; other site 1142394003305 H-loop/switch region; other site 1142394003306 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 1142394003307 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 1142394003308 Pyruvate/oxaloacetate carboxyltransferase [Energy production and conversion]; Region: COG5016 1142394003309 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1142394003310 active site 1142394003311 catalytic residues [active] 1142394003312 metal binding site [ion binding]; metal-binding site 1142394003313 Mycoplasma pulmonis MnuA nuclease-like; Region: MnuA_DNase1-like; cd10283 1142394003314 putative active site [active] 1142394003315 putative catalytic site [active] 1142394003316 putative Mg binding site IVb [ion binding]; other site 1142394003317 putative phosphate binding site [ion binding]; other site 1142394003318 putative DNA binding site [nucleotide binding]; other site 1142394003319 putative Mg binding site IVa [ion binding]; other site 1142394003320 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 1142394003321 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1142394003322 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1142394003323 glutamine binding [chemical binding]; other site 1142394003324 catalytic triad [active] 1142394003325 SecA DEAD-like domain; Region: SecA_DEAD; smart00957 1142394003326 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1142394003327 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 1142394003328 ribonuclease PH; Reviewed; Region: rph; PRK00173 1142394003329 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 1142394003330 oligomer interface [polypeptide binding]; other site 1142394003331 RNA binding site [nucleotide binding]; other site 1142394003332 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1142394003333 Alpha-crystallin domain (ACD) of alpha-crystallin-type small(s) heat shock proteins (Hsps). sHsps are small stress induced proteins with monomeric masses between 12 -43 kDa, whose common feature is the Alpha-crystallin domain (ACD). sHsps are generally...; Region: ACD_sHsps-like; cd06464 1142394003334 putative dimer interface [polypeptide binding]; other site 1142394003335 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1142394003336 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1142394003337 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1142394003338 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1142394003339 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1142394003340 substrate binding site [chemical binding]; other site 1142394003341 active site 1142394003342 catalytic residues [active] 1142394003343 heterodimer interface [polypeptide binding]; other site 1142394003344 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1142394003345 active site 1142394003346 ATP binding site [chemical binding]; other site 1142394003347 Serine/threonine protein kinase [General function prediction only / Signal transduction mechanisms / Transcription / DNA replication, recombination, and repair]; Region: SPS1; COG0515 1142394003348 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1142394003349 active site 1142394003350 ribulose/triose binding site [chemical binding]; other site 1142394003351 phosphate binding site [ion binding]; other site 1142394003352 substrate (anthranilate) binding pocket [chemical binding]; other site 1142394003353 product (indole) binding pocket [chemical binding]; other site 1142394003354 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1142394003355 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1142394003356 Walker A motif; other site 1142394003357 ATP binding site [chemical binding]; other site 1142394003358 Walker B motif; other site 1142394003359 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 1142394003360 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1142394003361 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1142394003362 Walker A motif; other site 1142394003363 ATP binding site [chemical binding]; other site 1142394003364 Walker B motif; other site 1142394003365 Protein of unknown function (DUF4038); Region: DUF4038; pfam13204 1142394003366 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 1142394003367 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1142394003368 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1142394003369 putative catalytic site [active] 1142394003370 putative metal binding site [ion binding]; other site 1142394003371 putative phosphate binding site [ion binding]; other site 1142394003372 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 1142394003373 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1142394003374 ligand binding site [chemical binding]; other site 1142394003375 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1142394003376 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 1142394003377 putative active site [active] 1142394003378 oxyanion strand; other site 1142394003379 catalytic triad [active] 1142394003380 Protein of unknown function DUF89; Region: DUF89; cl15397 1142394003381 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 1142394003382 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 1142394003383 tetramer interface [polypeptide binding]; other site 1142394003384 active site 1142394003385 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 1142394003386 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1142394003387 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1142394003388 DNA binding residues [nucleotide binding] 1142394003389 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1142394003390 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1142394003391 metal binding site [ion binding]; metal-binding site 1142394003392 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 1142394003393 proposed catalytic triad [active] 1142394003394 active site nucleophile [active] 1142394003395 Predicted membrane protein [Function unknown]; Region: COG1288 1142394003396 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1142394003397 active site 1142394003398 Zn binding site [ion binding]; other site 1142394003399 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 1142394003400 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1142394003401 metal ion-dependent adhesion site (MIDAS); other site 1142394003402 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 1142394003403 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1142394003404 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 1142394003405 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1142394003406 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1142394003407 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 1142394003408 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 1142394003409 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 1142394003410 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1142394003411 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1142394003412 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1142394003413 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1142394003414 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1142394003415 dimer interface [polypeptide binding]; other site 1142394003416 ssDNA binding site [nucleotide binding]; other site 1142394003417 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1142394003418 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 1142394003419 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 1142394003420 Chlam_Verruc_Plancto small basic protein; Region: Chlam_Ver_rRNA; TIGR04137 1142394003421 aspartate aminotransferase; Provisional; Region: PRK05764 1142394003422 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1142394003423 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1142394003424 homodimer interface [polypeptide binding]; other site 1142394003425 catalytic residue [active] 1142394003426 biotin synthase; Region: bioB; TIGR00433 1142394003427 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1142394003428 FeS/SAM binding site; other site 1142394003429 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1142394003430 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1142394003431 tRNA synthetases class I (C) catalytic domain; Region: tRNA-synt_1e; pfam01406 1142394003432 active site 1142394003433 HIGH motif; other site 1142394003434 nucleotide binding site [chemical binding]; other site 1142394003435 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1142394003436 KMSKS motif; other site 1142394003437 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1142394003438 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1142394003439 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1142394003440 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1142394003441 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1142394003442 DNA binding site [nucleotide binding] 1142394003443 domain linker motif; other site 1142394003444 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1142394003445 ligand binding site [chemical binding]; other site 1142394003446 dimerization interface [polypeptide binding]; other site 1142394003447 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1142394003448 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 1142394003449 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1142394003450 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1142394003451 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 1142394003452 Amidohydrolase; Region: Amidohydro_2; pfam04909 1142394003453 active site 1142394003454 RbsD / FucU transport protein family; Region: RbsD_FucU; cl00809 1142394003455 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1142394003456 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1142394003457 putative NAD(P) binding site [chemical binding]; other site 1142394003458 catalytic Zn binding site [ion binding]; other site 1142394003459 structural Zn binding site [ion binding]; other site 1142394003460 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1142394003461 active site 1142394003462 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1142394003463 catalytic tetrad [active] 1142394003464 Alpha-L-fucosidase; Region: Alpha_L_fucos; smart00812 1142394003465 Alpha-L-fucosidase [Carbohydrate transport and metabolism]; Region: COG3669 1142394003466 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1142394003467 Sulfatase; Region: Sulfatase; cl17466 1142394003468 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1142394003469 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 1142394003470 Protein of unknown function, DUF479; Region: DUF479; cl01203 1142394003471 Glycosyl hydrolases family 35; Region: Glyco_hydro_35; pfam01301 1142394003472 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1142394003473 oligomerisation interface [polypeptide binding]; other site 1142394003474 mobile loop; other site 1142394003475 roof hairpin; other site 1142394003476 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 1142394003477 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 1142394003478 Cytochrome oxidase assembly protein; Region: COX15-CtaA; cl15852 1142394003479 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1142394003480 UbiA prenyltransferase family; Region: UbiA; pfam01040 1142394003481 ABC transporter, ATP-binding subunit, PQQ-dependent alcohol dehydrogenase system; Region: PQQ_ABC_ATP; TIGR03864 1142394003482 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1142394003483 Walker A/P-loop; other site 1142394003484 ATP binding site [chemical binding]; other site 1142394003485 Q-loop/lid; other site 1142394003486 ABC transporter signature motif; other site 1142394003487 Walker B; other site 1142394003488 D-loop; other site 1142394003489 H-loop/switch region; other site 1142394003490 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1142394003491 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1142394003492 binding surface 1142394003493 TPR motif; other site 1142394003494 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1142394003495 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1142394003496 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1142394003497 HlyD family secretion protein; Region: HlyD_3; pfam13437 1142394003498 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12898 1142394003499 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 1142394003500 Flagellar protein FliS; Region: FliS; cl00654 1142394003501 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1142394003502 active site 1142394003503 phosphorylation site [posttranslational modification] 1142394003504 intermolecular recognition site; other site 1142394003505 dimerization interface [polypeptide binding]; other site 1142394003506 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1142394003507 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1142394003508 metal binding site [ion binding]; metal-binding site 1142394003509 active site 1142394003510 I-site; other site 1142394003511 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1142394003512 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1142394003513 PAS domain; Region: PAS_9; pfam13426 1142394003514 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1142394003515 ATP binding site [chemical binding]; other site 1142394003516 Mg2+ binding site [ion binding]; other site 1142394003517 G-X-G motif; other site 1142394003518 Protein of unknown function (DUF342); Region: DUF342; pfam03961 1142394003519 PAS fold; Region: PAS_3; pfam08447 1142394003520 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1142394003521 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1142394003522 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1142394003523 dimer interface [polypeptide binding]; other site 1142394003524 phosphorylation site [posttranslational modification] 1142394003525 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1142394003526 ATP binding site [chemical binding]; other site 1142394003527 G-X-G motif; other site 1142394003528 Response regulator receiver domain; Region: Response_reg; pfam00072 1142394003529 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1142394003530 active site 1142394003531 phosphorylation site [posttranslational modification] 1142394003532 intermolecular recognition site; other site 1142394003533 dimerization interface [polypeptide binding]; other site 1142394003534 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 1142394003535 putative active site [active] 1142394003536 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 1142394003537 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1142394003538 putative molybdopterin cofactor binding site [chemical binding]; other site 1142394003539 Molybdopterin-Binding, C-terminal (MopB_CT) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum-...; Region: MopB_CT; cl09929 1142394003540 molybdopterin cofactor binding site; other site 1142394003541 FdhD/NarQ family; Region: FdhD-NarQ; cl00659 1142394003542 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1142394003543 extended (e) SDRs; Region: SDR_e; cd08946 1142394003544 NAD(P) binding site [chemical binding]; other site 1142394003545 active site 1142394003546 substrate binding site [chemical binding]; other site 1142394003547 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1142394003548 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 1142394003549 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 1142394003550 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1142394003551 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1142394003552 putative dimer interface [polypeptide binding]; other site 1142394003553 [2Fe-2S] cluster binding site [ion binding]; other site 1142394003554 Predicted ATPase [General function prediction only]; Region: COG4637 1142394003555 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1142394003556 Walker A/P-loop; other site 1142394003557 ATP binding site [chemical binding]; other site 1142394003558 Domain of unknown function (DUF4276); Region: DUF4276; pfam14103 1142394003559 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 1142394003560 SLBB domain; Region: SLBB; pfam10531 1142394003561 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1142394003562 Uncharacterized ACR, COG1678; Region: DUF179; cl00731 1142394003563 LysE type translocator; Region: LysE; cl00565 1142394003564 Domain of unknown function (DUF4394); Region: DUF4394; pfam14339 1142394003565 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1142394003566 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1142394003567 phosphopeptide binding site; other site 1142394003568 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 1142394003569 putative hydrophobic ligand binding site [chemical binding]; other site 1142394003570 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1142394003571 TIGR01777 family protein; Region: yfcH 1142394003572 putative NAD(P) binding site [chemical binding]; other site 1142394003573 putative active site [active] 1142394003574 mce related protein; Region: MCE; pfam02470 1142394003575 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1142394003576 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1142394003577 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1142394003578 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1142394003579 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1142394003580 active site 1142394003581 ATP-dependent DNA helicase PcrA; Region: pcrA; TIGR01073 1142394003582 Part of AAA domain; Region: AAA_19; pfam13245 1142394003583 Family description; Region: UvrD_C_2; pfam13538 1142394003584 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: RecN; COG0497 1142394003585 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1142394003586 Walker A/P-loop; other site 1142394003587 ATP binding site [chemical binding]; other site 1142394003588 Q-loop/lid; other site 1142394003589 Walker B; other site 1142394003590 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1142394003591 ABC transporter signature motif; other site 1142394003592 Walker B; other site 1142394003593 D-loop; other site 1142394003594 H-loop/switch region; other site 1142394003595 AAA domain; Region: AAA_23; pfam13476 1142394003596 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1142394003597 Walker A/P-loop; other site 1142394003598 ATP binding site [chemical binding]; other site 1142394003599 AAA domain; Region: AAA_21; pfam13304 1142394003600 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1142394003601 Walker B; other site 1142394003602 D-loop; other site 1142394003603 H-loop/switch region; other site 1142394003604 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1142394003605 active site 1142394003606 metal binding site [ion binding]; metal-binding site 1142394003607 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 1142394003608 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1142394003609 homodimer interface [polypeptide binding]; other site 1142394003610 putative active site [active] 1142394003611 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1142394003612 oligomeric interface; other site 1142394003613 homodimer interface [polypeptide binding]; other site 1142394003614 putative active site [active] 1142394003615 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1142394003616 S-adenosylmethionine binding site [chemical binding]; other site 1142394003617 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1142394003618 putative active site [active] 1142394003619 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1142394003620 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1142394003621 NAD(P) binding site [chemical binding]; other site 1142394003622 active site 1142394003623 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 1142394003624 Lumazine binding domain; Region: Lum_binding; pfam00677 1142394003625 Lumazine binding domain; Region: Lum_binding; pfam00677 1142394003626 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1142394003627 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1142394003628 radical SAM/Cys-rich domain protein; Region: rSAM_SeCys; TIGR04167 1142394003629 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1142394003630 FeS/SAM binding site; other site 1142394003631 Protein of unknown function (DUF3641); Region: DUF3641; pfam12345 1142394003632 Predicted kinase [General function prediction only]; Region: COG4857; cl17281 1142394003633 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 1142394003634 active site 1142394003635 Protein of unknown function, DUF547; Region: DUF547; pfam04784 1142394003636 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1142394003637 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1142394003638 FAD binding pocket [chemical binding]; other site 1142394003639 FAD binding motif [chemical binding]; other site 1142394003640 phosphate binding motif [ion binding]; other site 1142394003641 beta-alpha-beta structure motif; other site 1142394003642 NAD binding pocket [chemical binding]; other site 1142394003643 Allophanate hydrolase subunit 2; Region: AHS2; cl00865 1142394003644 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1142394003645 Allophanate hydrolase subunit 1 [Amino acid transport and metabolism]; Region: DUR1; cl00896 1142394003646 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1142394003647 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity. They also contain a...; Region: Nudix_Hydrolase_1; cd03674 1142394003648 nudix motif; other site 1142394003649 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1142394003650 nicotinate (nicotinamide) nucleotide adenylyltransferase; Region: TIGR00482 1142394003651 active site 1142394003652 (T/H)XGH motif; other site 1142394003653 Beta-galactosidase/beta-glucuronidase [Carbohydrate transport and metabolism]; Region: LacZ; COG3250 1142394003654 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1142394003655 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1142394003656 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 1142394003657 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1142394003658 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1142394003659 phosphopeptide binding site; other site 1142394003660 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1142394003661 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1142394003662 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1142394003663 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1142394003664 ATP binding site [chemical binding]; other site 1142394003665 Mg2+ binding site [ion binding]; other site 1142394003666 G-X-G motif; other site 1142394003667 argininosuccinate lyase; Provisional; Region: PRK00855 1142394003668 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1142394003669 active sites [active] 1142394003670 tetramer interface [polypeptide binding]; other site 1142394003671 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1142394003672 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 1142394003673 homodimer interface [polypeptide binding]; other site 1142394003674 substrate-cofactor binding pocket; other site 1142394003675 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1142394003676 catalytic residue [active] 1142394003677 Galactokinase [Carbohydrate transport and metabolism]; Region: GalK; COG0153 1142394003678 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1142394003679 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1142394003680 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1142394003681 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1142394003682 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1142394003683 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1142394003684 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1142394003685 dimer interface [polypeptide binding]; other site 1142394003686 active site 1142394003687 CoA binding pocket [chemical binding]; other site 1142394003688 putative phosphate acyltransferase; Provisional; Region: PRK05331 1142394003689 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 1142394003690 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1142394003691 Protein of unknown function (DUF1622); Region: DUF1622; pfam07784 1142394003692 Exopolysaccharide synthesis, ExoD; Region: ExoD; pfam06055 1142394003693 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like_2; cd04847 1142394003694 active site 1142394003695 catalytic triad [active] 1142394003696 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1142394003697 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 1142394003698 Walker A motif; other site 1142394003699 ATP binding site [chemical binding]; other site 1142394003700 Walker B motif; other site 1142394003701 arginine finger; other site 1142394003702 Protein of unknown function (DUF511); Region: DUF511; cl01114 1142394003703 GIY-YIG nuclease domain superfamily; Region: GIY-YIG_SF; cd00719 1142394003704 GIY-YIG motif/motif A; other site 1142394003705 active site 1142394003706 catalytic site [active] 1142394003707 metal binding site [ion binding]; metal-binding site 1142394003708 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1142394003709 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1142394003710 ATP binding site [chemical binding]; other site 1142394003711 putative Mg++ binding site [ion binding]; other site 1142394003712 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1142394003713 nucleotide binding region [chemical binding]; other site 1142394003714 ATP-binding site [chemical binding]; other site 1142394003715 CAAX protease self-immunity; Region: Abi; pfam02517 1142394003716 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1142394003717 AAA domain; Region: AAA_23; pfam13476 1142394003718 Walker A/P-loop; other site 1142394003719 ATP binding site [chemical binding]; other site 1142394003720 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1142394003721 active site 1142394003722 metal binding site [ion binding]; metal-binding site 1142394003723 DNA binding site [nucleotide binding] 1142394003724 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1142394003725 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1142394003726 active site 1142394003727 tetramer interface [polypeptide binding]; other site 1142394003728 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1142394003729 active site 1142394003730 TSCPD domain; Region: TSCPD; pfam12637 1142394003731 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1142394003732 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1142394003733 active site 1142394003734 phosphorylation site [posttranslational modification] 1142394003735 intermolecular recognition site; other site 1142394003736 dimerization interface [polypeptide binding]; other site 1142394003737 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1142394003738 Walker A motif; other site 1142394003739 ATP binding site [chemical binding]; other site 1142394003740 Walker B motif; other site 1142394003741 arginine finger; other site 1142394003742 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1142394003743 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1142394003744 homotrimer interaction site [polypeptide binding]; other site 1142394003745 zinc binding site [ion binding]; other site 1142394003746 CDP-binding sites; other site 1142394003747 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 1142394003748 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 1142394003749 putative trimer interface [polypeptide binding]; other site 1142394003750 putative CoA binding site [chemical binding]; other site 1142394003751 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 1142394003752 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1142394003753 PhoH-like protein; Region: PhoH; pfam02562 1142394003754 7TM receptor with intracellular HD hydrolase; Region: 7TM-7TMR_HD; pfam07698 1142394003755 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1142394003756 Zn2+ binding site [ion binding]; other site 1142394003757 Mg2+ binding site [ion binding]; other site 1142394003758 argininosuccinate synthase; Provisional; Region: PRK13820 1142394003759 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1142394003760 ANP binding site [chemical binding]; other site 1142394003761 Substrate Binding Site II [chemical binding]; other site 1142394003762 Substrate Binding Site I [chemical binding]; other site 1142394003763 Succinylarginine dihydrolase; Region: AstB; cl01511 1142394003764 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1142394003765 NAD(P) binding site [chemical binding]; other site 1142394003766 catalytic residues [active] 1142394003767 Arginine N-succinyltransferase beta subunit; Region: AstA; cl11440 1142394003768 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1142394003769 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1142394003770 metal binding site [ion binding]; metal-binding site 1142394003771 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1142394003772 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 1142394003773 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 1142394003774 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1142394003775 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1142394003776 ligand binding site [chemical binding]; other site 1142394003777 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 1142394003778 active site 1142394003779 catalytic residues [active] 1142394003780 serine O-acetyltransferase; Region: cysE; TIGR01172 1142394003781 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1142394003782 trimer interface [polypeptide binding]; other site 1142394003783 active site 1142394003784 substrate binding site [chemical binding]; other site 1142394003785 CoA binding site [chemical binding]; other site 1142394003786 HupE / UreJ protein; Region: HupE_UreJ_2; pfam13795 1142394003787 Domain of unknown function (DUF4331); Region: DUF4331; pfam14224 1142394003788 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cl17215 1142394003789 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 1142394003790 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1142394003791 Zn2+ binding site [ion binding]; other site 1142394003792 Mg2+ binding site [ion binding]; other site 1142394003793 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1142394003794 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 1142394003795 active site 1142394003796 catalytic residues [active] 1142394003797 DNA binding site [nucleotide binding] 1142394003798 Int/Topo IB signature motif; other site 1142394003799 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 1142394003800 Helix-turn-helix domain; Region: HTH_17; cl17695 1142394003801 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 1142394003802 Catalytic site; other site 1142394003803 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1142394003804 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1142394003805 Walker A/P-loop; other site 1142394003806 ATP binding site [chemical binding]; other site 1142394003807 Q-loop/lid; other site 1142394003808 ABC transporter signature motif; other site 1142394003809 Walker B; other site 1142394003810 D-loop; other site 1142394003811 H-loop/switch region; other site 1142394003812 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1142394003813 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1142394003814 dimerization interface [polypeptide binding]; other site 1142394003815 DPS ferroxidase diiron center [ion binding]; other site 1142394003816 ion pore; other site 1142394003817 glutamine synthetase; Region: PLN02284 1142394003818 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1142394003819 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1142394003820 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 1142394003821 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1142394003822 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1142394003823 dimer interface [polypeptide binding]; other site 1142394003824 conserved gate region; other site 1142394003825 putative PBP binding loops; other site 1142394003826 ABC-ATPase subunit interface; other site 1142394003827 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1142394003828 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1142394003829 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1142394003830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1142394003831 dimer interface [polypeptide binding]; other site 1142394003832 conserved gate region; other site 1142394003833 putative PBP binding loops; other site 1142394003834 ABC-ATPase subunit interface; other site 1142394003835 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1142394003836 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1142394003837 Sulfatase; Region: Sulfatase; pfam00884 1142394003838 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1142394003839 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1142394003840 DNA-binding site [nucleotide binding]; DNA binding site 1142394003841 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1142394003842 ligand binding site [chemical binding]; other site 1142394003843 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1142394003844 L-arabinose isomerase [Carbohydrate transport and metabolism]; Region: AraA; COG2160 1142394003845 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cd00578 1142394003846 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1142394003847 trimer interface [polypeptide binding]; other site 1142394003848 substrate binding site [chemical binding]; other site 1142394003849 Mn binding site [ion binding]; other site 1142394003850 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1142394003851 MFS/sugar transport protein; Region: MFS_2; pfam13347 1142394003852 Sulfatase; Region: Sulfatase; cl17466 1142394003853 Sulfatase; Region: Sulfatase; cl17466 1142394003854 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1142394003855 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1142394003856 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1142394003857 Sulfatase; Region: Sulfatase; pfam00884 1142394003858 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1142394003859 DNA-binding site [nucleotide binding]; DNA binding site 1142394003860 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1142394003861 ligand binding site [chemical binding]; other site 1142394003862 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1142394003863 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1142394003864 active site 1142394003865 DNA polymerase IV; Validated; Region: PRK02406 1142394003866 DNA binding site [nucleotide binding] 1142394003867 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 1142394003868 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 1142394003869 TPP-binding site [chemical binding]; other site 1142394003870 Pyruvate ferredoxin oxidoreductase beta subunit C terminal; Region: PFO_beta_C; pfam12367 1142394003871 Clp protease; Region: CLP_protease; pfam00574 1142394003872 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1142394003873 oligomer interface [polypeptide binding]; other site 1142394003874 active site residues [active] 1142394003875 polysaccharide deacetylase family protein, PEP-CTERM locus subfamily; Region: pepcterm_polyde; TIGR03006 1142394003876 Catalytic NodB homology domain of the carbohydrate esterase 4 superfamily; Region: CE4_SF; cl15692 1142394003877 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1142394003878 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1142394003879 Ligand binding site; other site 1142394003880 Putative Catalytic site; other site 1142394003881 DXD motif; other site 1142394003882 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1142394003883 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1142394003884 ornithine carbamoyltransferase; Provisional; Region: PRK00779 1142394003885 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1142394003886 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1142394003887 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1142394003888 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1142394003889 active site 1142394003890 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 1142394003891 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1142394003892 Walker A/P-loop; other site 1142394003893 ATP binding site [chemical binding]; other site 1142394003894 Q-loop/lid; other site 1142394003895 ABC transporter signature motif; other site 1142394003896 Walker B; other site 1142394003897 D-loop; other site 1142394003898 H-loop/switch region; other site 1142394003899 ABC transporter; Region: ABC_tran_2; pfam12848 1142394003900 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1142394003901 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 1142394003902 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1142394003903 NAD binding site [chemical binding]; other site 1142394003904 ligand binding site [chemical binding]; other site 1142394003905 catalytic site [active] 1142394003906 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1142394003907 trimer interface [polypeptide binding]; other site 1142394003908 active site 1142394003909 malate dehydrogenase; Provisional; Region: PRK05442 1142394003910 Chloroplast-like malate dehydrogenases; Region: MDH_choloroplast_like; cd01338 1142394003911 NAD(P) binding site [chemical binding]; other site 1142394003912 dimer interface [polypeptide binding]; other site 1142394003913 malate binding site [chemical binding]; other site 1142394003914 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1142394003915 active site 1142394003916 metal binding site [ion binding]; metal-binding site 1142394003917 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1142394003918 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1142394003919 HlyD family secretion protein; Region: HlyD_3; pfam13437 1142394003920 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1142394003921 amidase catalytic site [active] 1142394003922 Zn binding residues [ion binding]; other site 1142394003923 substrate binding site [chemical binding]; other site 1142394003924 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1142394003925 dimer interface [polypeptide binding]; other site 1142394003926 conserved gate region; other site 1142394003927 putative PBP binding loops; other site 1142394003928 ABC-ATPase subunit interface; other site 1142394003929 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1142394003930 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1142394003931 dimer interface [polypeptide binding]; other site 1142394003932 conserved gate region; other site 1142394003933 putative PBP binding loops; other site 1142394003934 ABC-ATPase subunit interface; other site 1142394003935 Bacterial protein of unknown function (DUF839); Region: DUF839; pfam05787 1142394003936 Folate-dependent phosphoribosylglycinamide formyltransferase PurN [Nucleotide transport and metabolism]; Region: PurN; COG0299 1142394003937 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1142394003938 active site 1142394003939 substrate binding site [chemical binding]; other site 1142394003940 cosubstrate binding site; other site 1142394003941 catalytic site [active] 1142394003942 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1142394003943 active site 1142394003944 HIGH motif; other site 1142394003945 nucleotide binding site [chemical binding]; other site 1142394003946 active site 1142394003947 KMSKS motif; other site 1142394003948 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 1142394003949 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1142394003950 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1142394003951 active site 1142394003952 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1142394003953 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1142394003954 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1142394003955 active site 1142394003956 HIGH motif; other site 1142394003957 dimer interface [polypeptide binding]; other site 1142394003958 KMSKS motif; other site 1142394003959 Outer membrane efflux protein; Region: OEP; pfam02321 1142394003960 Outer membrane efflux protein; Region: OEP; pfam02321 1142394003961 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1142394003962 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1142394003963 substrate binding site [chemical binding]; other site 1142394003964 ligand binding site [chemical binding]; other site 1142394003965 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1142394003966 SmpB-tmRNA interface; other site 1142394003967 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1142394003968 active site residue [active] 1142394003969 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1142394003970 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1142394003971 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1142394003972 FeS/SAM binding site; other site 1142394003973 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1142394003974 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 1142394003975 Exonuclease VII small subunit; Region: Exonuc_VII_S; pfam02609 1142394003976 Uncharacterized conserved protein [Function unknown]; Region: COG1624 1142394003977 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 1142394003978 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1142394003979 putative catalytic cysteine [active] 1142394003980 recombination factor protein RarA; Reviewed; Region: PRK13342 1142394003981 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1142394003982 Walker A motif; other site 1142394003983 ATP binding site [chemical binding]; other site 1142394003984 Walker B motif; other site 1142394003985 arginine finger; other site 1142394003986 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1142394003987 FOG: LysM repeat [Cell envelope biogenesis, outer membrane]; Region: LytE; COG1388 1142394003988 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1142394003989 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1142394003990 Uncharacterized protein conserved in bacteria [Function unknown]; Region: ErfK; COG1376 1142394003991 putative bifunctional trehalose-6-phosphate synthase/HAD hydrolase subfamily IIB; Provisional; Region: PRK14501 1142394003992 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1142394003993 active site 1142394003994 homotetramer interface [polypeptide binding]; other site 1142394003995 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187; cl17105 1142394003996 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1142394003997 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 1142394003998 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1142394003999 S-adenosylmethionine binding site [chemical binding]; other site 1142394004000 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 1142394004001 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1142394004002 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1142394004003 dimer interface [polypeptide binding]; other site 1142394004004 PYR/PP interface [polypeptide binding]; other site 1142394004005 TPP binding site [chemical binding]; other site 1142394004006 substrate binding site [chemical binding]; other site 1142394004007 FAD binding domain of DNA photolyase; Region: FAD_binding_7; pfam03441 1142394004008 YceI-like domain; Region: YceI; pfam04264 1142394004009 YceI-like domain; Region: YceI; pfam04264 1142394004010 aconitate hydratase; Validated; Region: PRK09277 1142394004011 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1142394004012 substrate binding site [chemical binding]; other site 1142394004013 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1142394004014 ligand binding site [chemical binding]; other site 1142394004015 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1142394004016 substrate binding site [chemical binding]; other site 1142394004017 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1142394004018 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1142394004019 Putative catalytic domain of uncharacterized bacterial polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_1; cd10940 1142394004020 putative active site [active] 1142394004021 putative catalytic site [active] 1142394004022 putative Zn binding site [ion binding]; other site 1142394004023 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 1142394004024 hypothetical protein; Provisional; Region: PRK07233 1142394004025 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1142394004026 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1142394004027 putative trimer interface [polypeptide binding]; other site 1142394004028 putative CoA binding site [chemical binding]; other site 1142394004029 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1142394004030 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1142394004031 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1142394004032 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1142394004033 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1142394004034 inhibitor-cofactor binding pocket; inhibition site 1142394004035 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1142394004036 catalytic residue [active] 1142394004037 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1142394004038 catalytic residues [active] 1142394004039 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1142394004040 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1142394004041 metal binding site [ion binding]; metal-binding site 1142394004042 active site 1142394004043 I-site; other site 1142394004044 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 1142394004045 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1142394004046 active site 1142394004047 homodimer interface [polypeptide binding]; other site 1142394004048 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 1142394004049 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 1142394004050 active site 1142394004051 Zn binding site [ion binding]; other site 1142394004052 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1142394004053 active site 1142394004054 metal binding site [ion binding]; metal-binding site 1142394004055 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1142394004056 Bacterial PH domain; Region: DUF304; pfam03703 1142394004057 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1142394004058 active site 1142394004059 Flagellar basal-body P-ring protein [Cell motility and secretion]; Region: FlgI; COG1706 1142394004060 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1142394004061 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1142394004062 tandem repeat interface [polypeptide binding]; other site 1142394004063 oligomer interface [polypeptide binding]; other site 1142394004064 active site residues [active] 1142394004065 Protein of unknown function DUF111; Region: DUF111; cl03398 1142394004066 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 1142394004067 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1142394004068 active site 1142394004069 thiamine phosphate binding site [chemical binding]; other site 1142394004070 pyrophosphate binding site [ion binding]; other site 1142394004071 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 1142394004072 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1142394004073 NAD(P) binding site [chemical binding]; other site 1142394004074 active site 1142394004075 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1142394004076 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1142394004077 active site 1142394004078 phosphorylation site [posttranslational modification] 1142394004079 intermolecular recognition site; other site 1142394004080 dimerization interface [polypeptide binding]; other site 1142394004081 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1142394004082 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1142394004083 metal binding site [ion binding]; metal-binding site 1142394004084 active site 1142394004085 I-site; other site 1142394004086 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1142394004087 PAS fold; Region: PAS_4; pfam08448 1142394004088 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1142394004089 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1142394004090 ATP binding site [chemical binding]; other site 1142394004091 G-X-G motif; other site 1142394004092 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1142394004093 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1142394004094 active site 1142394004095 catalytic tetrad [active] 1142394004096 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 1142394004097 TPP-binding site [chemical binding]; other site 1142394004098 Transketolase, C-terminal subunit [Carbohydrate transport and metabolism]; Region: COG3958 1142394004099 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1142394004100 PYR/PP interface [polypeptide binding]; other site 1142394004101 dimer interface [polypeptide binding]; other site 1142394004102 TPP binding site [chemical binding]; other site 1142394004103 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1142394004104 Phosphorylase superfamily; Region: PNP_UDP_1; cl00303 1142394004105 acetolactate synthase, large subunit, biosynthetic type; Region: acolac_lg; TIGR00118 1142394004106 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1142394004107 PYR/PP interface [polypeptide binding]; other site 1142394004108 dimer interface [polypeptide binding]; other site 1142394004109 TPP binding site [chemical binding]; other site 1142394004110 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1142394004111 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1142394004112 TPP-binding site [chemical binding]; other site 1142394004113 dimer interface [polypeptide binding]; other site 1142394004114 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1142394004115 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1142394004116 active site 1142394004117 catalytic site [active] 1142394004118 PEP-CTERM protein-sorting domain; Region: PEP_exosort; TIGR02595 1142394004119 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1142394004120 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1142394004121 DNA binding site [nucleotide binding] 1142394004122 domain linker motif; other site 1142394004123 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1142394004124 dimerization interface [polypeptide binding]; other site 1142394004125 ligand binding site [chemical binding]; other site 1142394004126 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1142394004127 Early set domain associated with the catalytic domain of sugar utilizing enzymes at either the N or C terminus; Region: E_set; cl09101 1142394004128 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1142394004129 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1142394004130 active site 1142394004131 homodimer interface [polypeptide binding]; other site 1142394004132 catalytic site [active] 1142394004133 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 1142394004134 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 1142394004135 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1142394004136 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1142394004137 putative methanogenesis marker protein 1; Region: methan_mark_1; TIGR03266 1142394004138 YcaO-like family; Region: YcaO; pfam02624 1142394004139 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1142394004140 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1142394004141 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1142394004142 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1142394004143 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1142394004144 active site 1142394004145 NAD binding site [chemical binding]; other site 1142394004146 metal binding site [ion binding]; metal-binding site 1142394004147 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1142394004148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 1142394004149 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 1142394004150 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1142394004151 generic binding surface II; other site 1142394004152 generic binding surface I; other site 1142394004153 Protein of unknown function, DUF547; Region: DUF547; pfam04784 1142394004154 excinuclease ABC subunit B; Provisional; Region: PRK05298 1142394004155 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1142394004156 ATP binding site [chemical binding]; other site 1142394004157 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1142394004158 nucleotide binding region [chemical binding]; other site 1142394004159 ATP-binding site [chemical binding]; other site 1142394004160 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1142394004161 UvrB/uvrC motif; Region: UVR; pfam02151 1142394004162 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1142394004163 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1142394004164 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1142394004165 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1142394004166 RNA binding site [nucleotide binding]; other site 1142394004167 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1142394004168 RNA binding site [nucleotide binding]; other site 1142394004169 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1142394004170 RNA binding site [nucleotide binding]; other site 1142394004171 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1142394004172 RNA binding site [nucleotide binding]; other site 1142394004173 domain interface; other site 1142394004174 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1142394004175 RNA binding site [nucleotide binding]; other site 1142394004176 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 1142394004177 active site 1142394004178 DNA binding site [nucleotide binding] 1142394004179 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 1142394004180 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 1142394004181 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1142394004182 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1142394004183 Uncharacterized conserved protein [Function unknown]; Region: COG2135 1142394004184 competence damage-inducible protein A; Provisional; Region: PRK00549 1142394004185 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1142394004186 putative MPT binding site; other site 1142394004187 Competence-damaged protein; Region: CinA; pfam02464 1142394004188 PHP domain; Region: PHP; pfam02811 1142394004189 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1142394004190 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1142394004191 NAD binding site [chemical binding]; other site 1142394004192 catalytic Zn binding site [ion binding]; other site 1142394004193 structural Zn binding site [ion binding]; other site 1142394004194 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1142394004195 putative active site pocket [active] 1142394004196 dimerization interface [polypeptide binding]; other site 1142394004197 putative catalytic residue [active] 1142394004198 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 1142394004199 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1142394004200 catalytic residue [active] 1142394004201 PilZ domain; Region: PilZ; pfam07238 1142394004202 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1142394004203 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1142394004204 active site 1142394004205 metal binding site [ion binding]; metal-binding site 1142394004206 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1142394004207 PCRF domain; Region: PCRF; cl17745 1142394004208 RF-1 domain; Region: RF-1; pfam00472 1142394004209 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1142394004210 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1142394004211 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cd00449 1142394004212 homodimer interface [polypeptide binding]; other site 1142394004213 substrate-cofactor binding pocket; other site 1142394004214 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1142394004215 catalytic residue [active] 1142394004216 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1142394004217 Zn2+ binding site [ion binding]; other site 1142394004218 Mg2+ binding site [ion binding]; other site 1142394004219 AIR carboxylase; Region: AIRC; smart01001 1142394004220 Protein of unknown function (DUF2959); Region: DUF2959; pfam11172 1142394004221 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1142394004222 HEAT repeats; Region: HEAT_2; pfam13646 1142394004223 PBP superfamily domain; Region: PBP_like_2; cl17296 1142394004224 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 1142394004225 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1142394004226 dimer interface [polypeptide binding]; other site 1142394004227 conserved gate region; other site 1142394004228 putative PBP binding loops; other site 1142394004229 ABC-ATPase subunit interface; other site 1142394004230 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1142394004231 ABC-ATPase subunit interface; other site 1142394004232 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 1142394004233 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1142394004234 Walker A/P-loop; other site 1142394004235 ATP binding site [chemical binding]; other site 1142394004236 Q-loop/lid; other site 1142394004237 ABC transporter signature motif; other site 1142394004238 Walker B; other site 1142394004239 D-loop; other site 1142394004240 H-loop/switch region; other site 1142394004241 NADH dehydrogenase subunit B; Validated; Region: PRK06411 1142394004242 ketol-acid reductoisomerase; Provisional; Region: PRK05479 1142394004243 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1142394004244 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1142394004245 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 1142394004246 active site 1142394004247 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 1142394004248 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1142394004249 HflX GTPase family; Region: HflX; cd01878 1142394004250 G1 box; other site 1142394004251 GTP/Mg2+ binding site [chemical binding]; other site 1142394004252 Switch I region; other site 1142394004253 G2 box; other site 1142394004254 G3 box; other site 1142394004255 Switch II region; other site 1142394004256 G4 box; other site 1142394004257 G5 box; other site 1142394004258 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 1142394004259 Cell division protein FtsA; Region: FtsA; pfam14450 1142394004260 hypothetical protein; Provisional; Region: PRK07208 1142394004261 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1142394004262 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1142394004263 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1142394004264 active site 1142394004265 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1142394004266 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1142394004267 active site 1142394004268 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1142394004269 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1142394004270 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 1142394004271 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 1142394004272 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 1142394004273 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1142394004274 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1142394004275 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1142394004276 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1142394004277 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1142394004278 active site 1142394004279 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1142394004280 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1142394004281 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1142394004282 active site 1142394004283 LexA repressor; Validated; Region: PRK00215 1142394004284 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1142394004285 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1142394004286 Catalytic site [active] 1142394004287 Isoprenoid Biosynthesis enzymes, Class 1; Region: Isoprenoid_Biosyn_C1; cl00210 1142394004288 substrate binding pocket [chemical binding]; other site 1142394004289 substrate-Mg2+ binding site; other site 1142394004290 aspartate-rich region 1; other site 1142394004291 aspartate-rich region 2; other site 1142394004292 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 1142394004293 active site lid residues [active] 1142394004294 substrate binding pocket [chemical binding]; other site 1142394004295 catalytic residues [active] 1142394004296 substrate-Mg2+ binding site; other site 1142394004297 aspartate-rich region 1; other site 1142394004298 aspartate-rich region 2; other site 1142394004299 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 1142394004300 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1142394004301 binding surface 1142394004302 TPR motif; other site 1142394004303 TPR repeat; Region: TPR_11; pfam13414 1142394004304 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1142394004305 binding surface 1142394004306 TPR motif; other site 1142394004307 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1142394004308 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1142394004309 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1142394004310 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1142394004311 ring oligomerisation interface [polypeptide binding]; other site 1142394004312 ATP/Mg binding site [chemical binding]; other site 1142394004313 stacking interactions; other site 1142394004314 hinge regions; other site 1142394004315 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1142394004316 oligomerisation interface [polypeptide binding]; other site 1142394004317 mobile loop; other site 1142394004318 roof hairpin; other site 1142394004319 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1142394004320 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1142394004321 ring oligomerisation interface [polypeptide binding]; other site 1142394004322 ATP/Mg binding site [chemical binding]; other site 1142394004323 stacking interactions; other site 1142394004324 hinge regions; other site 1142394004325 chaperone protein DnaJ; Provisional; Region: PRK10767 1142394004326 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1142394004327 HSP70 interaction site [polypeptide binding]; other site 1142394004328 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1142394004329 Zn binding sites [ion binding]; other site 1142394004330 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1142394004331 dimer interface [polypeptide binding]; other site 1142394004332 GrpE; Region: GrpE; pfam01025 1142394004333 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1142394004334 dimer interface [polypeptide binding]; other site 1142394004335 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1142394004336 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; pfam09723 1142394004337 integron integrase; Region: integrase_gron; TIGR02249 1142394004338 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1142394004339 active site 1142394004340 DNA binding site [nucleotide binding] 1142394004341 Int/Topo IB signature motif; other site 1142394004342 siroheme synthase; Provisional; Region: cysG; PRK10637 1142394004343 N-terminal domain of Streptomyces griseus SgaA (suppression of growth disturbance caused by A-factor at a high concentration under high osmolality during early growth phase), and similar domains; Region: SgaA_N_like; cd07247 1142394004344 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1142394004345 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1142394004346 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1142394004347 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1142394004348 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 1142394004349 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1142394004350 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1142394004351 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1142394004352 FAD binding domain; Region: FAD_binding_4; pfam01565 1142394004353 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 1142394004354 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 1142394004355 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1142394004356 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 1142394004357 Ligand binding site; other site 1142394004358 DXD motif; other site 1142394004359 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1142394004360 active site 1142394004361 Minimal MMP-like domain found in Acidothermus cellulolyticus hypothetical protein ACEL2062 and similar protein; Region: MMP_ACEL2062; cd12952 1142394004362 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 1142394004363 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1142394004364 FeS/SAM binding site; other site 1142394004365 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1142394004366 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1142394004367 Walker A/P-loop; other site 1142394004368 ATP binding site [chemical binding]; other site 1142394004369 Q-loop/lid; other site 1142394004370 ABC transporter signature motif; other site 1142394004371 Walker B; other site 1142394004372 D-loop; other site 1142394004373 H-loop/switch region; other site 1142394004374 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 1142394004375 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 1142394004376 CAAX protease self-immunity; Region: Abi; pfam02517 1142394004377 CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507 1142394004378 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1142394004379 conserved cys residue [active] 1142394004380 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1142394004381 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1142394004382 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1142394004383 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1142394004384 tandem repeat interface [polypeptide binding]; other site 1142394004385 oligomer interface [polypeptide binding]; other site 1142394004386 active site residues [active] 1142394004387 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1142394004388 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 1142394004389 tandem repeat interface [polypeptide binding]; other site 1142394004390 oligomer interface [polypeptide binding]; other site 1142394004391 active site residues [active] 1142394004392 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1142394004393 FAD binding domain; Region: FAD_binding_4; pfam01565 1142394004394 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1142394004395 Lipase (class 2); Region: Lipase_2; pfam01674 1142394004396 pyridoxine 5'-phosphate synthase; Provisional; Region: PRK05265 1142394004397 active site 1142394004398 hydrophilic channel; other site 1142394004399 dimerization interface [polypeptide binding]; other site 1142394004400 catalytic residues [active] 1142394004401 active site lid [active] 1142394004402 Glycerate kinase [Carbohydrate transport and metabolism]; Region: COG1929 1142394004403 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1142394004404 nucleoside/Zn binding site; other site 1142394004405 dimer interface [polypeptide binding]; other site 1142394004406 catalytic motif [active] 1142394004407 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1142394004408 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1142394004409 putative active site [active] 1142394004410 putative metal binding site [ion binding]; other site 1142394004411 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 1142394004412 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1142394004413 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1142394004414 Walker A motif; other site 1142394004415 ATP binding site [chemical binding]; other site 1142394004416 Walker B motif; other site 1142394004417 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1142394004418 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1142394004419 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1142394004420 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1142394004421 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1142394004422 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1142394004423 HINT (histidine triad nucleotide-binding protein) subgroup: Members of this CD belong to the superfamily of histidine triad hydrolases that act on alpha-phosphate of ribonucleotides. This subgroup includes members from all three forms of cellular life; Region: HINT_subgroup; cd01277 1142394004424 HIT family signature motif; other site 1142394004425 catalytic residue [active] 1142394004426 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1142394004427 active site 1142394004428 bifunctional molybdenum cofactor biosynthesis protein MoaC/MogA; Provisional; Region: moaC; PRK03604 1142394004429 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1142394004430 trimer interface [polypeptide binding]; other site 1142394004431 dimer interface [polypeptide binding]; other site 1142394004432 putative active site [active] 1142394004433 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1142394004434 MPT binding site; other site 1142394004435 trimer interface [polypeptide binding]; other site 1142394004436 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1142394004437 NMT1-like family; Region: NMT1_2; pfam13379 1142394004438 Response regulator with putative antiterminator output domain [Signal transduction mechanisms]; Region: AmiR; COG3707 1142394004439 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1142394004440 active site 1142394004441 phosphorylation site [posttranslational modification] 1142394004442 intermolecular recognition site; other site 1142394004443 ANTAR domain; Region: ANTAR; pfam03861 1142394004444 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1142394004445 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1142394004446 [4Fe-4S] binding site [ion binding]; other site 1142394004447 molybdopterin cofactor binding site; other site 1142394004448 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1142394004449 molybdopterin cofactor binding site; other site 1142394004450 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1142394004451 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1142394004452 Walker A/P-loop; other site 1142394004453 ATP binding site [chemical binding]; other site 1142394004454 Q-loop/lid; other site 1142394004455 ABC transporter signature motif; other site 1142394004456 Walker B; other site 1142394004457 D-loop; other site 1142394004458 H-loop/switch region; other site 1142394004459 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1142394004460 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1142394004461 Walker A/P-loop; other site 1142394004462 ATP binding site [chemical binding]; other site 1142394004463 Q-loop/lid; other site 1142394004464 ABC transporter signature motif; other site 1142394004465 Walker B; other site 1142394004466 D-loop; other site 1142394004467 H-loop/switch region; other site 1142394004468 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1142394004469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1142394004470 dimer interface [polypeptide binding]; other site 1142394004471 conserved gate region; other site 1142394004472 putative PBP binding loops; other site 1142394004473 ABC-ATPase subunit interface; other site 1142394004474 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 1142394004475 NMT1-like family; Region: NMT1_2; pfam13379 1142394004476 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09567 1142394004477 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1142394004478 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1142394004479 Sulfite reductase, alpha subunit (flavoprotein) [Inorganic ion transport and metabolism]; Region: CysJ; COG0369 1142394004480 Flavodoxin; Region: Flavodoxin_1; pfam00258 1142394004481 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1142394004482 FAD binding pocket [chemical binding]; other site 1142394004483 FAD binding motif [chemical binding]; other site 1142394004484 catalytic residues [active] 1142394004485 NAD binding pocket [chemical binding]; other site 1142394004486 phosphate binding motif [ion binding]; other site 1142394004487 beta-alpha-beta structure motif; other site 1142394004488 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1142394004489 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1142394004490 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1142394004491 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1142394004492 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1142394004493 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1142394004494 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1142394004495 active site 1142394004496 catalytic tetrad [active] 1142394004497 Class I aldolases; Region: Aldolase_Class_I; cl17187 1142394004498 transaldolase; Provisional; Region: PRK03903 1142394004499 catalytic residue [active] 1142394004500 MoxR-like ATPases [General function prediction only]; Region: COG0714 1142394004501 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1142394004502 Walker A motif; other site 1142394004503 ATP binding site [chemical binding]; other site 1142394004504 Walker B motif; other site 1142394004505 arginine finger; other site 1142394004506 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1142394004507 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1142394004508 Mg2+ binding site [ion binding]; other site 1142394004509 G-X-G motif; other site 1142394004510 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is...; Region: MutL_Trans; cd00782 1142394004511 ATP binding site [chemical binding]; other site 1142394004512 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1142394004513 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1142394004514 active site 1142394004515 catalytic triad [active] 1142394004516 oxyanion hole [active] 1142394004517 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1142394004518 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1142394004519 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1142394004520 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1142394004521 Ligand binding site; other site 1142394004522 Putative Catalytic site; other site 1142394004523 DXD motif; other site 1142394004524 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1142394004525 Ornithine/acetylornithine aminotransferase [Amino acid transport and metabolism]; Region: ArgD; COG4992 1142394004526 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1142394004527 catalytic residue [active] 1142394004528 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 1142394004529 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1142394004530 putative catalytic residue [active] 1142394004531 Disulphide bond corrector protein DsbC; Region: DsbC; cl15830 1142394004532 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1142394004533 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1142394004534 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1142394004535 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 1142394004536 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1142394004537 mce related protein; Region: MCE; pfam02470 1142394004538 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1142394004539 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1142394004540 Walker A/P-loop; other site 1142394004541 ATP binding site [chemical binding]; other site 1142394004542 Q-loop/lid; other site 1142394004543 ABC transporter signature motif; other site 1142394004544 Walker B; other site 1142394004545 D-loop; other site 1142394004546 H-loop/switch region; other site 1142394004547 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1142394004548 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1142394004549 inhibitor-cofactor binding pocket; inhibition site 1142394004550 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1142394004551 catalytic residue [active] 1142394004552 Y-family of DNA polymerases; Region: PolY; cl12025 1142394004553 DNA binding site [nucleotide binding] 1142394004554 error-prone DNA polymerase; Validated; Region: dnaE2; PRK05672 1142394004555 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III at DnaE2 gene; Region: PHP_PolIIIA_DnaE2; cd07434 1142394004556 putative active site [active] 1142394004557 putative PHP Thumb interface [polypeptide binding]; other site 1142394004558 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1142394004559 generic binding surface I; other site 1142394004560 generic binding surface II; other site 1142394004561 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1142394004562 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1142394004563 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1142394004564 dimer interface [polypeptide binding]; other site 1142394004565 motif 1; other site 1142394004566 active site 1142394004567 motif 2; other site 1142394004568 motif 3; other site 1142394004569 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1142394004570 ABC-type proline/glycine betaine transport systems, permease component [Amino acid transport and metabolism]; Region: OpuBB; COG1174 1142394004571 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 1142394004572 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1142394004573 Walker A/P-loop; other site 1142394004574 ATP binding site [chemical binding]; other site 1142394004575 Q-loop/lid; other site 1142394004576 ABC transporter signature motif; other site 1142394004577 Walker B; other site 1142394004578 D-loop; other site 1142394004579 H-loop/switch region; other site 1142394004580 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 1142394004581 DHH family; Region: DHH; pfam01368 1142394004582 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1142394004583 riboflavin kinase/FMN adenylyltransferase; Region: ribF; TIGR00083 1142394004584 active site 1142394004585 nucleotide binding site [chemical binding]; other site 1142394004586 HIGH motif; other site 1142394004587 KMSKS motif; other site 1142394004588 Riboflavin kinase; Region: Flavokinase; pfam01687 1142394004589 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1142394004590 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1142394004591 ATP binding site [chemical binding]; other site 1142394004592 DEAD_2; Region: DEAD_2; pfam06733 1142394004593 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1142394004594 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1142394004595 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1142394004596 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1142394004597 homodimer interface [polypeptide binding]; other site 1142394004598 catalytic residue [active] 1142394004599 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1142394004600 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1142394004601 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1142394004602 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1142394004603 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1142394004604 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_2; cd03814 1142394004605 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 1142394004606 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1142394004607 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1142394004608 catalytic loop [active] 1142394004609 iron binding site [ion binding]; other site 1142394004610 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1142394004611 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1142394004612 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 1142394004613 Zn-dependent alcohol dehydrogenases, class III [Energy production and conversion]; Region: AdhC; COG1062 1142394004614 Class III alcohol dehydrogenase; Region: Zn_ADH_class_III; cd08279 1142394004615 NAD binding site [chemical binding]; other site 1142394004616 catalytic Zn binding site [ion binding]; other site 1142394004617 substrate binding site [chemical binding]; other site 1142394004618 structural Zn binding site [ion binding]; other site 1142394004619 S-formylglutathione hydrolase; Region: PLN02442 1142394004620 Putative esterase; Region: Esterase; pfam00756 1142394004621 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4947 1142394004622 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 1142394004623 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1142394004624 NAD binding site [chemical binding]; other site 1142394004625 homotetramer interface [polypeptide binding]; other site 1142394004626 homodimer interface [polypeptide binding]; other site 1142394004627 substrate binding site [chemical binding]; other site 1142394004628 active site 1142394004629 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1142394004630 Response regulator receiver domain; Region: Response_reg; pfam00072 1142394004631 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1142394004632 active site 1142394004633 phosphorylation site [posttranslational modification] 1142394004634 intermolecular recognition site; other site 1142394004635 dimerization interface [polypeptide binding]; other site 1142394004636 Uncharacterized protein conserved in bacteria (DUF2064); Region: DUF2064; cl17492 1142394004637 Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; Region: PheT; COG0072 1142394004638 B3/4 domain; Region: B3_4; pfam03483 1142394004639 tRNA synthetase B5 domain; Region: B5; pfam03484 1142394004640 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1142394004641 RNA polymerase sigma factor; Provisional; Region: PRK11924 1142394004642 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1142394004643 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 1142394004644 ABC-ATPase subunit interface; other site 1142394004645 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1142394004646 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1142394004647 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1142394004648 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1142394004649 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1142394004650 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1142394004651 carboxyltransferase (CT) interaction site; other site 1142394004652 biotinylation site [posttranslational modification]; other site 1142394004653 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK01297 1142394004654 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1142394004655 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 1142394004656 dimer interface [polypeptide binding]; other site 1142394004657 active site 1142394004658 heme binding site [chemical binding]; other site 1142394004659 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1142394004660 heme binding site [chemical binding]; other site 1142394004661 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1142394004662 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 1142394004663 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 1142394004664 active site 1142394004665 Domain of unknown function (DUF1844); Region: DUF1844; pfam08899 1142394004666 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 1142394004667 succinate dehydrogenase (or fumarate reductase) cytochrome b subunit, b558 family; Region: sdhC_b558_fam; TIGR02046 1142394004668 putative Iron-sulfur protein interface [polypeptide binding]; other site 1142394004669 proximal heme binding site [chemical binding]; other site 1142394004670 distal heme binding site [chemical binding]; other site 1142394004671 putative dimer interface [polypeptide binding]; other site 1142394004672 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 1142394004673 L-aspartate oxidase; Provisional; Region: PRK06175 1142394004674 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1142394004675 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1142394004676 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1142394004677 Response regulator receiver domain; Region: Response_reg; pfam00072 1142394004678 active site 1142394004679 phosphorylation site [posttranslational modification] 1142394004680 intermolecular recognition site; other site 1142394004681 dimerization interface [polypeptide binding]; other site 1142394004682 PAS fold; Region: PAS_4; pfam08448 1142394004683 PAS fold; Region: PAS_3; pfam08447 1142394004684 Motif C-terminal to PAS motifs (likely to contribute to PAS structural domain); Region: PAC; smart00086 1142394004685 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1142394004686 dimer interface [polypeptide binding]; other site 1142394004687 phosphorylation site [posttranslational modification] 1142394004688 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1142394004689 ATP binding site [chemical binding]; other site 1142394004690 Mg2+ binding site [ion binding]; other site 1142394004691 G-X-G motif; other site 1142394004692 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1142394004693 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1142394004694 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1142394004695 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1142394004696 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1142394004697 Beta galactosidase small chain; Region: Bgal_small_N; cl03787 1142394004698 OAH/OAS sulfhydrylase; Region: OAH_OAS_sulfhy; TIGR01326 1142394004699 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1142394004700 homodimer interface [polypeptide binding]; other site 1142394004701 substrate-cofactor binding pocket; other site 1142394004702 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1142394004703 catalytic residue [active] 1142394004704 Protein of unknown function DUF86; Region: DUF86; cl01031 1142394004705 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 1142394004706 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1142394004707 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1142394004708 Active Sites [active] 1142394004709 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1142394004710 Ligand binding site; other site 1142394004711 Putative Catalytic site; other site 1142394004712 DXD motif; other site 1142394004713 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1142394004714 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1142394004715 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1142394004716 ABC transporter; Region: ABC_tran_2; pfam12848 1142394004717 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1142394004718 Domain of unknown function (DUF4380); Region: DUF4380; pfam14315 1142394004719 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1142394004720 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1142394004721 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1142394004722 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1142394004723 DNA binding site [nucleotide binding] 1142394004724 active site 1142394004725 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1142394004726 dimer interface [polypeptide binding]; other site 1142394004727 substrate binding site [chemical binding]; other site 1142394004728 metal binding sites [ion binding]; metal-binding site 1142394004729 oxidoreductase; Provisional; Region: PRK06128 1142394004730 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1142394004731 NAD(P) binding site [chemical binding]; other site 1142394004732 active site 1142394004733 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1142394004734 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1142394004735 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK13964 1142394004736 active site 1142394004737 (T/H)XGH motif; other site 1142394004738 DNA topoisomerase IV, B subunit, Gram-positive; Region: parE_Gpos; TIGR01058 1142394004739 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1142394004740 Mg2+ binding site [ion binding]; other site 1142394004741 G-X-G motif; other site 1142394004742 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1142394004743 anchoring element; other site 1142394004744 dimer interface [polypeptide binding]; other site 1142394004745 ATP binding site [chemical binding]; other site 1142394004746 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1142394004747 active site 1142394004748 putative metal-binding site [ion binding]; other site 1142394004749 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1142394004750 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 1142394004751 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1142394004752 rRNA interaction site [nucleotide binding]; other site 1142394004753 S8 interaction site; other site 1142394004754 putative laminin-1 binding site; other site 1142394004755 elongation factor Ts; Provisional; Region: tsf; PRK09377 1142394004756 Ubiquitin Associated domain. The UBA domain is a commonly occurring sequence motif in some members of the ubiquitination pathway, UV excision repair proteins, and certain protein kinases. Although its specific role is so far unknown, it has been...; Region: UBA; cl00153 1142394004757 Elongation factor TS; Region: EF_TS; pfam00889 1142394004758 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1142394004759 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 1142394004760 homodimer interface [polypeptide binding]; other site 1142394004761 substrate-cofactor binding pocket; other site 1142394004762 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1142394004763 catalytic residue [active] 1142394004764 Uncharacterized conserved protein [Function unknown]; Region: COG0585 1142394004765 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1142394004766 active site 1142394004767 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1142394004768 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 1142394004769 The tRNA binding domain is also known as the Myf domain in literature. This domain is found in a diverse collection of tRNA binding proteins, including prokaryotic phenylalanyl tRNA synthetases (PheRS), methionyl-tRNA synthetases (MetRS), human...; Region: tRNA_bindingDomain; cl00320 1142394004770 putative tRNA-binding site [nucleotide binding]; other site 1142394004771 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1142394004772 AAA domain; Region: AAA_26; pfam13500 1142394004773 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 1142394004774 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1142394004775 dimerization interface [polypeptide binding]; other site 1142394004776 NAD binding site [chemical binding]; other site 1142394004777 product binding site; other site 1142394004778 substrate binding site [chemical binding]; other site 1142394004779 zinc binding site [ion binding]; other site 1142394004780 catalytic residues [active] 1142394004781 Predicted divalent heavy-metal cations transporter [Inorganic ion transport and metabolism]; Region: COG0428; cl00437 1142394004782 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 1142394004783 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1142394004784 Cell division protein FtsI/penicillin-binding protein 2 [Cell envelope biogenesis, outer membrane]; Region: FtsI; COG0768 1142394004785 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1142394004786 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1142394004787 Predicted oxidoreductases of the aldo/keto reductase family [General function prediction only]; Region: COG1453 1142394004788 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1142394004789 active site 1142394004790 catalytic tetrad [active] 1142394004791 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 1142394004792 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1142394004793 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1142394004794 protein binding site [polypeptide binding]; other site 1142394004795 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1142394004796 protein binding site [polypeptide binding]; other site 1142394004797 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1142394004798 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1142394004799 TrkA-C domain; Region: TrkA_C; pfam02080 1142394004800 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1142394004801 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 1142394004802 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 1142394004803 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1142394004804 elongation factor P; Validated; Region: PRK00529 1142394004805 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1142394004806 RNA binding site [nucleotide binding]; other site 1142394004807 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1142394004808 RNA binding site [nucleotide binding]; other site 1142394004809 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1142394004810 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cd06587 1142394004811 active site 1142394004812 metal binding site [ion binding]; metal-binding site 1142394004813 Domain of unknown function (DUF3859); Region: DUF3859; pfam12975 1142394004814 Domain of unknown function (DUF3817); Region: DUF3817; cl14844 1142394004815 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1142394004816 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1142394004817 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1142394004818 Divalent cation transporter; Region: MgtE; cl00786 1142394004819 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1142394004820 Na binding site [ion binding]; other site 1142394004821 CAAX protease self-immunity; Region: Abi; pfam02517 1142394004822 Flagellar protein (FlbD); Region: FlbD; pfam06289 1142394004823 flagellar hook protein FlgE; Validated; Region: flgE; PRK05841 1142394004824 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1142394004825 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1142394004826 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1142394004827 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1142394004828 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 1142394004829 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 1142394004830 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1142394004831 Walker A motif; other site 1142394004832 ATP binding site [chemical binding]; other site 1142394004833 Walker B motif; other site 1142394004834 Flagellar assembly protein FliH; Region: FliH; pfam02108 1142394004835 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 1142394004836 FliG C-terminal domain; Region: FliG_C; pfam01706 1142394004837 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 1142394004838 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 1142394004839 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1142394004840 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1142394004841 Flagellar basal body protein [Cell motility and secretion]; Region: FlgB; COG1815 1142394004842 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 1142394004843 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1142394004844 active site 1142394004845 phosphorylation site [posttranslational modification] 1142394004846 intermolecular recognition site; other site 1142394004847 dimerization interface [polypeptide binding]; other site 1142394004848 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1142394004849 Walker A motif; other site 1142394004850 ATP binding site [chemical binding]; other site 1142394004851 Walker B motif; other site 1142394004852 arginine finger; other site 1142394004853 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1142394004854 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1142394004855 dimer interface [polypeptide binding]; other site 1142394004856 phosphorylation site [posttranslational modification] 1142394004857 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1142394004858 ATP binding site [chemical binding]; other site 1142394004859 Mg2+ binding site [ion binding]; other site 1142394004860 G-X-G motif; other site 1142394004861 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 1142394004862 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1142394004863 Kynurenine formamidase [Amino acid transport and metabolism]; Region: COG1878 1142394004864 Transposase domain (DUF772); Region: DUF772; pfam05598 1142394004865 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1142394004866 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1142394004867 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 1142394004868 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1142394004869 putative active site [active] 1142394004870 putative metal binding site [ion binding]; other site 1142394004871 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 1142394004872 active site 1142394004873 ATP binding site [chemical binding]; other site 1142394004874 substrate binding site [chemical binding]; other site 1142394004875 RNA polymerase sigma factor, cyanobacterial RpoD-like family; Region: Sig70-cyanoRpoD; TIGR02997 1142394004876 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1142394004877 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1142394004878 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1142394004879 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1142394004880 DNA binding residues [nucleotide binding] 1142394004881 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1142394004882 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1142394004883 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1142394004884 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1142394004885 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1142394004886 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1142394004887 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1142394004888 NAD(P) binding site [chemical binding]; other site 1142394004889 active site 1142394004890 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 1142394004891 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1142394004892 active site 1142394004893 Protein of unknown function, DUF547; Region: DUF547; pfam04784 1142394004894 aminotransferase; Validated; Region: PRK08175 1142394004895 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1142394004896 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1142394004897 homodimer interface [polypeptide binding]; other site 1142394004898 catalytic residue [active] 1142394004899 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 1142394004900 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1142394004901 Walker A/P-loop; other site 1142394004902 ATP binding site [chemical binding]; other site 1142394004903 Q-loop/lid; other site 1142394004904 ABC transporter signature motif; other site 1142394004905 Walker B; other site 1142394004906 D-loop; other site 1142394004907 H-loop/switch region; other site 1142394004908 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1142394004909 Permease; Region: Permease; pfam02405 1142394004910 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1142394004911 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1142394004912 anti sigma factor interaction site; other site 1142394004913 regulatory phosphorylation site [posttranslational modification]; other site 1142394004914 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1142394004915 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 1142394004916 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1142394004917 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1142394004918 substrate binding pocket [chemical binding]; other site 1142394004919 chain length determination region; other site 1142394004920 substrate-Mg2+ binding site; other site 1142394004921 catalytic residues [active] 1142394004922 aspartate-rich region 1; other site 1142394004923 active site lid residues [active] 1142394004924 aspartate-rich region 2; other site 1142394004925 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1142394004926 GAF domain; Region: GAF; pfam01590 1142394004927 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1142394004928 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1142394004929 active site 1142394004930 phosphorylation site [posttranslational modification] 1142394004931 intermolecular recognition site; other site 1142394004932 dimerization interface [polypeptide binding]; other site 1142394004933 BON domain; Region: BON; pfam04972 1142394004934 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1142394004935 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1142394004936 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 1142394004937 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1142394004938 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1142394004939 ssDNA binding site; other site 1142394004940 generic binding surface II; other site 1142394004941 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1142394004942 ATP binding site [chemical binding]; other site 1142394004943 putative Mg++ binding site [ion binding]; other site 1142394004944 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1142394004945 nucleotide binding region [chemical binding]; other site 1142394004946 ATP-binding site [chemical binding]; other site 1142394004947 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1142394004948 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1142394004949 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1142394004950 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1142394004951 arginine-tRNA ligase; Region: PLN02286 1142394004952 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1142394004953 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1142394004954 active site 1142394004955 HIGH motif; other site 1142394004956 KMSK motif region; other site 1142394004957 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1142394004958 tRNA binding surface [nucleotide binding]; other site 1142394004959 anticodon binding site; other site 1142394004960 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1142394004961 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1142394004962 active site 1142394004963 phosphorylation site [posttranslational modification] 1142394004964 intermolecular recognition site; other site 1142394004965 dimerization interface [polypeptide binding]; other site 1142394004966 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1142394004967 DNA binding residues [nucleotide binding] 1142394004968 dimerization interface [polypeptide binding]; other site 1142394004969 PAS fold; Region: PAS_4; pfam08448 1142394004970 PAS fold; Region: PAS_4; pfam08448 1142394004971 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1142394004972 putative active site [active] 1142394004973 heme pocket [chemical binding]; other site 1142394004974 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 1142394004975 Histidine kinase; Region: HisKA_3; pfam07730 1142394004976 GMP synthase; Reviewed; Region: guaA; PRK00074 1142394004977 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1142394004978 AMP/PPi binding site [chemical binding]; other site 1142394004979 candidate oxyanion hole; other site 1142394004980 catalytic triad [active] 1142394004981 potential glutamine specificity residues [chemical binding]; other site 1142394004982 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1142394004983 ATP Binding subdomain [chemical binding]; other site 1142394004984 Ligand Binding sites [chemical binding]; other site 1142394004985 Dimerization subdomain; other site 1142394004986 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1142394004987 putative active site pocket [active] 1142394004988 4-fold oligomerization interface [polypeptide binding]; other site 1142394004989 metal binding residues [ion binding]; metal-binding site 1142394004990 3-fold/trimer interface [polypeptide binding]; other site 1142394004991 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 1142394004992 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1142394004993 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1142394004994 homodimer interface [polypeptide binding]; other site 1142394004995 catalytic residue [active] 1142394004996 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1142394004997 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1142394004998 inhibitor-cofactor binding pocket; inhibition site 1142394004999 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1142394005000 catalytic residue [active] 1142394005001 Protein of unknown function, DUF481; Region: DUF481; pfam04338 1142394005002 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1142394005003 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1142394005004 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 1142394005005 active site 1142394005006 Fe-S cluster binding site [ion binding]; other site 1142394005007 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1142394005008 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1142394005009 dimer interface [polypeptide binding]; other site 1142394005010 anticodon binding site; other site 1142394005011 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1142394005012 homodimer interface [polypeptide binding]; other site 1142394005013 motif 1; other site 1142394005014 active site 1142394005015 motif 2; other site 1142394005016 GAD domain; Region: GAD; pfam02938 1142394005017 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1142394005018 active site 1142394005019 motif 3; other site 1142394005020 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 1142394005021 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1142394005022 active site 1142394005023 dimer interface [polypeptide binding]; other site 1142394005024 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1142394005025 Ligand Binding Site [chemical binding]; other site 1142394005026 Molecular Tunnel; other site 1142394005027 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1142394005028 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 1142394005029 putative catalytic site [active] 1142394005030 putative metal binding site [ion binding]; other site 1142394005031 putative phosphate binding site [ion binding]; other site 1142394005032 Bacteriorhodopsin-like protein; Region: Bac_rhodopsin; smart01021 1142394005033 elongation factor G; Reviewed; Region: PRK00007 1142394005034 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1142394005035 G1 box; other site 1142394005036 putative GEF interaction site [polypeptide binding]; other site 1142394005037 GTP/Mg2+ binding site [chemical binding]; other site 1142394005038 Switch I region; other site 1142394005039 G2 box; other site 1142394005040 G3 box; other site 1142394005041 Switch II region; other site 1142394005042 G4 box; other site 1142394005043 G5 box; other site 1142394005044 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1142394005045 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1142394005046 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1142394005047 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1142394005048 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1142394005049 Coenzyme A binding pocket [chemical binding]; other site 1142394005050 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1142394005051 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1142394005052 CoA-ligase; Region: Ligase_CoA; pfam00549 1142394005053 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1142394005054 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1142394005055 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1142394005056 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1142394005057 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 1142394005058 Transmembrane exosortase (Exosortase_EpsH); Region: Exosortase_EpsH; pfam09721 1142394005059 Predicted membrane protein [Function unknown]; Region: COG4083; cl15694 1142394005060 Protein of unknown function (DUF3485); Region: DUF3485; cl11827 1142394005061 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1142394005062 TPR motif; other site 1142394005063 binding surface 1142394005064 TPR repeat; Region: TPR_11; pfam13414 1142394005065 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1142394005066 binding surface 1142394005067 TPR motif; other site 1142394005068 exopolysaccharide/PEP-CTERM locus tyrosine autokinase; Region: pepcterm_TyrKin; TIGR03018 1142394005069 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cd01983 1142394005070 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1142394005071 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1142394005072 NAD(P) binding site [chemical binding]; other site 1142394005073 active site 1142394005074 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 1142394005075 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1142394005076 Mg++ binding site [ion binding]; other site 1142394005077 putative catalytic motif [active] 1142394005078 substrate binding site [chemical binding]; other site 1142394005079 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1142394005080 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1142394005081 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1142394005082 hinge region; other site 1142394005083 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1142394005084 putative nucleotide binding site [chemical binding]; other site 1142394005085 uridine monophosphate binding site [chemical binding]; other site 1142394005086 homohexameric interface [polypeptide binding]; other site 1142394005087 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1142394005088 metal-binding site [ion binding] 1142394005089 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1142394005090 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1142394005091 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1142394005092 Outer membrane efflux protein; Region: OEP; pfam02321 1142394005093 Outer membrane efflux protein; Region: OEP; pfam02321 1142394005094 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1142394005095 dimerization interface [polypeptide binding]; other site 1142394005096 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1142394005097 putative homodimer interface [polypeptide binding]; other site 1142394005098 putative homotetramer interface [polypeptide binding]; other site 1142394005099 putative allosteric switch controlling residues; other site 1142394005100 putative metal binding site [ion binding]; other site 1142394005101 putative homodimer-homodimer interface [polypeptide binding]; other site 1142394005102 Methyltransferase domain; Region: Methyltransf_18; pfam12847 1142394005103 acetyl-CoA synthetase; Provisional; Region: PRK00174 1142394005104 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1142394005105 active site 1142394005106 CoA binding site [chemical binding]; other site 1142394005107 acyl-activating enzyme (AAE) consensus motif; other site 1142394005108 AMP binding site [chemical binding]; other site 1142394005109 acetate binding site [chemical binding]; other site 1142394005110 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 1142394005111 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1142394005112 HlyD family secretion protein; Region: HlyD_3; pfam13437 1142394005113 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 1142394005114 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1142394005115 Protein of unknown function (DUF4011); Region: DUF4011; pfam13195 1142394005116 Part of AAA domain; Region: AAA_19; pfam13245 1142394005117 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1142394005118 Helix-turn-helix domain; Region: HTH_17; pfam12728 1142394005119 Response regulator receiver domain; Region: Response_reg; pfam00072 1142394005120 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1142394005121 active site 1142394005122 phosphorylation site [posttranslational modification] 1142394005123 intermolecular recognition site; other site 1142394005124 dimerization interface [polypeptide binding]; other site 1142394005125 HDOD domain; Region: HDOD; pfam08668 1142394005126 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1142394005127 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1142394005128 dimer interface [polypeptide binding]; other site 1142394005129 phosphorylation site [posttranslational modification] 1142394005130 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1142394005131 ATP binding site [chemical binding]; other site 1142394005132 Mg2+ binding site [ion binding]; other site 1142394005133 G-X-G motif; other site 1142394005134 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1142394005135 Sulfatase; Region: Sulfatase; pfam00884 1142394005136 Polysaccharide biosynthesis protein; Region: Polysacc_synt_2; pfam02719 1142394005137 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 1142394005138 NAD(P) binding site [chemical binding]; other site 1142394005139 homodimer interface [polypeptide binding]; other site 1142394005140 substrate binding site [chemical binding]; other site 1142394005141 active site 1142394005142 PilZ domain; Region: PilZ; pfam07238 1142394005143 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1142394005144 Homeodomain-like domain; Region: HTH_23; cl17451 1142394005145 Winged helix-turn helix; Region: HTH_29; pfam13551 1142394005146 Homeodomain-like domain; Region: HTH_32; pfam13565 1142394005147 Haemolysin-III related; Region: HlyIII; cl03831 1142394005148 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1142394005149 potential protein location (hypothetical protein) that overlaps protein (putative transposase) 1142394005150 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 1142394005151 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 1142394005152 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1142394005153 dimer interface [polypeptide binding]; other site 1142394005154 active site 1142394005155 acyl carrier protein; Provisional; Region: acpP; PRK00982 1142394005156 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1142394005157 3-oxoacyl-(acyl-carrier-protein) reductase; Region: 3oxo_ACP_reduc; TIGR01830 1142394005158 NAD(P) binding site [chemical binding]; other site 1142394005159 active site 1142394005160 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 1142394005161 L-aspartate oxidase; Provisional; Region: PRK06175 1142394005162 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1142394005163 Late embryogenesis abundant protein; Region: LEA_2; pfam03168 1142394005164 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 1142394005165 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1142394005166 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1142394005167 DNA binding residues [nucleotide binding] 1142394005168 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1142394005169 SRP54-type protein, GTPase domain; Region: SRP54; smart00962 1142394005170 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1142394005171 FHIPEP family; Region: FHIPEP; pfam00771 1142394005172 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1142394005173 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1142394005174 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 1142394005175 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1142394005176 CoA binding domain; Region: CoA_binding; smart00881 1142394005177 CoA-ligase; Region: Ligase_CoA; pfam00549 1142394005178 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1142394005179 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1142394005180 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 1142394005181 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1142394005182 Catalytic site [active] 1142394005183 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1142394005184 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1142394005185 putative valine binding site [chemical binding]; other site 1142394005186 dimer interface [polypeptide binding]; other site 1142394005187 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1142394005188 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 1142394005189 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1142394005190 Low molecular weight phosphatase family; Region: LMWPc; cl00105 1142394005191 active site 1142394005192 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1142394005193 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1142394005194 Walker A/P-loop; other site 1142394005195 ATP binding site [chemical binding]; other site 1142394005196 Q-loop/lid; other site 1142394005197 ABC transporter signature motif; other site 1142394005198 Walker B; other site 1142394005199 D-loop; other site 1142394005200 H-loop/switch region; other site 1142394005201 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1142394005202 metal ion-dependent adhesion site (MIDAS); other site 1142394005203 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1142394005204 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1142394005205 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1142394005206 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1142394005207 trimer interface [polypeptide binding]; other site 1142394005208 active site 1142394005209 UDP-GlcNAc binding site [chemical binding]; other site 1142394005210 lipid binding site [chemical binding]; lipid-binding site 1142394005211 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1142394005212 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1142394005213 enolase; Provisional; Region: eno; PRK00077 1142394005214 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1142394005215 dimer interface [polypeptide binding]; other site 1142394005216 metal binding site [ion binding]; metal-binding site 1142394005217 substrate binding pocket [chemical binding]; other site 1142394005218 PQQ-like domain; Region: PQQ_2; pfam13360 1142394005219 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1142394005220 PQQ-like domain; Region: PQQ_2; pfam13360 1142394005221 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 1142394005222 active site 1142394005223 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1142394005224 purine monophosphate binding site [chemical binding]; other site 1142394005225 dimer interface [polypeptide binding]; other site 1142394005226 putative catalytic residues [active] 1142394005227 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 1142394005228 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1142394005229 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1142394005230 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 1142394005231 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 1142394005232 Protein of unknown function (DUF1800); Region: DUF1800; pfam08811 1142394005233 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 1142394005234 MgtE intracellular N domain; Region: MgtE_N; pfam03448 1142394005235 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 1142394005236 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 1142394005237 Divalent cation transporter; Region: MgtE; cl00786 1142394005238 Survival protein SurE; Region: SurE; cl00448 1142394005239 diaminopimelate decarboxylase; Provisional; Region: PRK11165 1142394005240 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1142394005241 active site 1142394005242 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1142394005243 substrate binding site [chemical binding]; other site 1142394005244 catalytic residues [active] 1142394005245 dimer interface [polypeptide binding]; other site 1142394005246 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1142394005247 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1142394005248 NADP binding site [chemical binding]; other site 1142394005249 active site 1142394005250 putative substrate binding site [chemical binding]; other site 1142394005251 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1142394005252 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1142394005253 NADP-binding site; other site 1142394005254 homotetramer interface [polypeptide binding]; other site 1142394005255 substrate binding site [chemical binding]; other site 1142394005256 homodimer interface [polypeptide binding]; other site 1142394005257 active site 1142394005258 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1142394005259 catalytic triad [active] 1142394005260 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1142394005261 Homeodomain-like domain; Region: HTH_23; cl17451 1142394005262 Winged helix-turn helix; Region: HTH_29; pfam13551 1142394005263 Homeodomain-like domain; Region: HTH_32; pfam13565 1142394005264 ribonuclease III; Reviewed; Region: rnc; PRK00102 1142394005265 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1142394005266 dimerization interface [polypeptide binding]; other site 1142394005267 active site 1142394005268 metal binding site [ion binding]; metal-binding site 1142394005269 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1142394005270 dsRNA binding site [nucleotide binding]; other site 1142394005271 SpoIVB peptidase S55; Region: Peptidase_S55; pfam05580 1142394005272 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 1142394005273 AAA domain; Region: AAA_33; pfam13671 1142394005274 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1142394005275 ATP-binding site [chemical binding]; other site 1142394005276 Gluconate-6-phosphate binding site [chemical binding]; other site 1142394005277 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1142394005278 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 1142394005279 Walker A/P-loop; other site 1142394005280 ATP binding site [chemical binding]; other site 1142394005281 Q-loop/lid; other site 1142394005282 ABC transporter signature motif; other site 1142394005283 Walker B; other site 1142394005284 D-loop; other site 1142394005285 H-loop/switch region; other site 1142394005286 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1142394005287 TrkA-N domain; Region: TrkA_N; pfam02254 1142394005288 TrkA-C domain; Region: TrkA_C; pfam02080 1142394005289 TrkA-N domain; Region: TrkA_N; pfam02254 1142394005290 TrkA-C domain; Region: TrkA_C; pfam02080 1142394005291 phosphatidylserine decarboxylase; Provisional; Region: PRK05305 1142394005292 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1142394005293 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1142394005294 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1142394005295 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1142394005296 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1142394005297 ATP binding site [chemical binding]; other site 1142394005298 putative Mg++ binding site [ion binding]; other site 1142394005299 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1142394005300 nucleotide binding region [chemical binding]; other site 1142394005301 ATP-binding site [chemical binding]; other site 1142394005302 TRCF domain; Region: TRCF; pfam03461 1142394005303 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1142394005304 Serine hydrolase (FSH1); Region: FSH1; pfam03959 1142394005305 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1142394005306 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 1142394005307 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1142394005308 Glycerol kinase [Energy production and conversion]; Region: GlpK; COG0554 1142394005309 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1142394005310 nucleotide binding site [chemical binding]; other site 1142394005311 Putative bacterial sensory transduction regulator; Region: YbjN; cl15834 1142394005312 GAF domain; Region: GAF; pfam01590 1142394005313 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1142394005314 Uncharacterized protein family (UPF0075); Region: UPF0075; cl04217 1142394005315 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1142394005316 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 1142394005317 DNA topoisomerase IV subunit B; Reviewed; Region: PRK05559 1142394005318 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1142394005319 ATP binding site [chemical binding]; other site 1142394005320 Mg2+ binding site [ion binding]; other site 1142394005321 G-X-G motif; other site 1142394005322 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1142394005323 anchoring element; other site 1142394005324 dimer interface [polypeptide binding]; other site 1142394005325 ATP binding site [chemical binding]; other site 1142394005326 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1142394005327 active site 1142394005328 putative metal-binding site [ion binding]; other site 1142394005329 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1142394005330 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 1142394005331 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1142394005332 active site 1142394005333 metal binding site [ion binding]; metal-binding site 1142394005334 Glycosyl hydrolase family 1; Region: Glyco_hydro_1; cl01046 1142394005335 beta-galactosidase; Region: BGL; TIGR03356 1142394005336 Glycosyl hydrolase family 53; Region: Glyco_hydro_53; cl06672 1142394005337 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cd06532 1142394005338 bidirectional hydrogenase complex protein HoxU; Validated; Region: PRK07569 1142394005339 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1142394005340 catalytic loop [active] 1142394005341 iron binding site [ion binding]; other site 1142394005342 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1142394005343 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1142394005344 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cd00368 1142394005345 rod shape-determining protein MreC; Provisional; Region: PRK13922 1142394005346 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1142394005347 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 1142394005348 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1142394005349 flagellar motor switch protein FliN; Region: fliN; TIGR02480 1142394005350 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 1142394005351 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1142394005352 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1142394005353 Predicted naringenin-chalcone synthase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BcsA; COG3424 1142394005354 active site 1142394005355 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1142394005356 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1142394005357 Walker A/P-loop; other site 1142394005358 ATP binding site [chemical binding]; other site 1142394005359 Q-loop/lid; other site 1142394005360 ABC transporter signature motif; other site 1142394005361 Walker B; other site 1142394005362 D-loop; other site 1142394005363 H-loop/switch region; other site 1142394005364 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1142394005365 Thermophilic metalloprotease (M29); Region: Peptidase_M29; pfam02073 1142394005366 Leucyl aminopeptidase (aminopeptidase T) [Amino acid transport and metabolism]; Region: AmpS; COG2309 1142394005367 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1142394005368 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1142394005369 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1142394005370 Protein export membrane protein; Region: SecD_SecF; pfam02355 1142394005371 Preprotein translocase subunit; Region: YajC; pfam02699 1142394005372 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; cl00409 1142394005373 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 1142394005374 glycine dehydrogenase; Provisional; Region: PRK05367 1142394005375 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1142394005376 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1142394005377 catalytic residue [active] 1142394005378 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1142394005379 tetramer interface [polypeptide binding]; other site 1142394005380 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1142394005381 catalytic residue [active] 1142394005382 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1142394005383 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1142394005384 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1142394005385 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1142394005386 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 1142394005387 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1142394005388 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1142394005389 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1142394005390 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1142394005391 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1142394005392 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1142394005393 inhibitor-cofactor binding pocket; inhibition site 1142394005394 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1142394005395 catalytic residue [active] 1142394005396 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1142394005397 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1142394005398 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1142394005399 alphaNTD homodimer interface [polypeptide binding]; other site 1142394005400 alphaNTD - beta interaction site [polypeptide binding]; other site 1142394005401 alphaNTD - beta' interaction site [polypeptide binding]; other site 1142394005402 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1142394005403 30S ribosomal protein S11; Validated; Region: PRK05309 1142394005404 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1142394005405 Ribosomal protein S13/S18; Region: Ribosomal_S13; cl00331 1142394005406 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1142394005407 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1142394005408 rRNA binding site [nucleotide binding]; other site 1142394005409 predicted 30S ribosome binding site; other site 1142394005410 PAP-phosphatase_like domains. PAP-phosphatase is a member of the inositol monophosphatase family, and catalyses the hydrolysis of 3'-phosphoadenosine-5'-phosphate (PAP) to AMP. In Saccharomyces cerevisiae, HAL2 (MET22) is involved in methionine...; Region: PAP_phosphatase; cd01517 1142394005411 active site 1142394005412 putative lithium-binding site [ion binding]; other site 1142394005413 substrate binding site [chemical binding]; other site 1142394005414 GTP-binding protein LepA; Provisional; Region: PRK05433 1142394005415 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1142394005416 G1 box; other site 1142394005417 putative GEF interaction site [polypeptide binding]; other site 1142394005418 GTP/Mg2+ binding site [chemical binding]; other site 1142394005419 Switch I region; other site 1142394005420 G2 box; other site 1142394005421 G3 box; other site 1142394005422 Switch II region; other site 1142394005423 G4 box; other site 1142394005424 G5 box; other site 1142394005425 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1142394005426 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1142394005427 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1142394005428 FOG: WD40 repeat [General function prediction only]; Region: COG2319 1142394005429 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 1142394005430 structural tetrad; other site 1142394005431 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 1142394005432 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1142394005433 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1142394005434 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1142394005435 Walker A motif; other site 1142394005436 ATP binding site [chemical binding]; other site 1142394005437 Walker B motif; other site 1142394005438 GMP synthase - Glutamine amidotransferase domain [Nucleotide transport and metabolism]; Region: GuaA; COG0518 1142394005439 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_1; cd01741 1142394005440 catalytic triad [active] 1142394005441 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1142394005442 minor groove reading motif; other site 1142394005443 helix-hairpin-helix signature motif; other site 1142394005444 active site 1142394005445 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1142394005446 C-terminus of AA_permease; Region: AA_permease_C; pfam13906 1142394005447 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cl00163 1142394005448 active site 1142394005449 phosphorylation site [posttranslational modification] 1142394005450 TrkA-C domain; Region: TrkA_C; pfam02080 1142394005451 Protein of unknown function (DUF1810); Region: DUF1810; pfam08837 1142394005452 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1142394005453 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1142394005454 catalytic residues [active] 1142394005455 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1142394005456 active site 1142394005457 dimerization interface [polypeptide binding]; other site 1142394005458 Uncharacterized conserved protein [Function unknown]; Region: COG1543 1142394005459 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1142394005460 Domain of unknown function (DUF1957); Region: DUF1957; pfam09210 1142394005461 CARDB; Region: CARDB; pfam07705 1142394005462 Domain of unknown function DUF11; Region: DUF11; cl17728 1142394005463 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1142394005464 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1142394005465 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1142394005466 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1142394005467 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1142394005468 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1142394005469 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1142394005470 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 1142394005471 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1142394005472 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1142394005473 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1142394005474 ABC-ATPase subunit interface; other site 1142394005475 putative PBP binding loops; other site 1142394005476 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1142394005477 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1142394005478 trimer interface [polypeptide binding]; other site 1142394005479 putative metal binding site [ion binding]; other site 1142394005480 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1142394005481 active site 2 [active] 1142394005482 active site 1 [active] 1142394005483 Phosphopantetheine attachment site; Region: PP-binding; cl09936 1142394005484 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 1142394005485 Carbon starvation protein CstA; Region: CstA; pfam02554 1142394005486 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1142394005487 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1142394005488 active site 2 [active] 1142394005489 active site 1 [active] 1142394005490 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1142394005491 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 1142394005492 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1142394005493 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1142394005494 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 1142394005495 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 1142394005496 phosphopeptide binding site; other site 1142394005497 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 1142394005498 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 1142394005499 DRE-TIM metallolyase superfamily; Region: DRE_TIM_metallolyase; cl07974 1142394005500 active site 1142394005501 catalytic residues [active] 1142394005502 metal binding site [ion binding]; metal-binding site 1142394005503 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; cl07212 1142394005504 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1142394005505 active site 1142394005506 catalytic residues [active] 1142394005507 metal binding site [ion binding]; metal-binding site 1142394005508 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1142394005509 IHF - DNA interface [nucleotide binding]; other site 1142394005510 IHF dimer interface [polypeptide binding]; other site 1142394005511 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 1142394005512 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1142394005513 catalytic residue [active] 1142394005514 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 1142394005515 dimanganese center [ion binding]; other site 1142394005516 Domain of unknown function (DUF4142); Region: DUF4142; pfam13628 1142394005517 Glycosyl hydrolase families 32 and 68, which for the clan GH-J; Region: GH_J; cd08979 1142394005518 active site 1142394005519 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1142394005520 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1142394005521 N-terminal catalytic domain of a thermoactive alpha-amylase from Methanococcus jannaschii and similar proteins; glycoside hydrolase family 57 (GH57); Region: GH57N_MJA1_like; cd10795 1142394005522 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 1142394005523 putative active site [active] 1142394005524 catalytic site [active] 1142394005525 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1142394005526 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 1142394005527 active site 1142394005528 PHP Thumb interface [polypeptide binding]; other site 1142394005529 metal binding site [ion binding]; metal-binding site 1142394005530 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1142394005531 generic binding surface II; other site 1142394005532 generic binding surface I; other site 1142394005533 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1142394005534 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1142394005535 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1142394005536 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1142394005537 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1142394005538 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1142394005539 active site 1142394005540 ATP binding site [chemical binding]; other site 1142394005541 substrate binding site [chemical binding]; other site 1142394005542 activation loop (A-loop); other site 1142394005543 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1142394005544 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 1142394005545 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1142394005546 CysD dimerization site [polypeptide binding]; other site 1142394005547 G1 box; other site 1142394005548 putative GEF interaction site [polypeptide binding]; other site 1142394005549 GTP/Mg2+ binding site [chemical binding]; other site 1142394005550 Switch I region; other site 1142394005551 G2 box; other site 1142394005552 G3 box; other site 1142394005553 Switch II region; other site 1142394005554 G4 box; other site 1142394005555 G5 box; other site 1142394005556 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1142394005557 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1142394005558 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1142394005559 ligand-binding site [chemical binding]; other site 1142394005560 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1142394005561 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1142394005562 Active Sites [active] 1142394005563 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 1142394005564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1142394005565 active site 1142394005566 phosphorylation site [posttranslational modification] 1142394005567 intermolecular recognition site; other site 1142394005568 dimerization interface [polypeptide binding]; other site 1142394005569 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1142394005570 Zn2+ binding site [ion binding]; other site 1142394005571 Mg2+ binding site [ion binding]; other site 1142394005572 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1142394005573 Response regulator receiver domain; Region: Response_reg; pfam00072 1142394005574 active site 1142394005575 phosphorylation site [posttranslational modification] 1142394005576 intermolecular recognition site; other site 1142394005577 dimerization interface [polypeptide binding]; other site 1142394005578 Response regulator receiver domain; Region: Response_reg; pfam00072 1142394005579 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1142394005580 active site 1142394005581 phosphorylation site [posttranslational modification] 1142394005582 intermolecular recognition site; other site 1142394005583 dimerization interface [polypeptide binding]; other site 1142394005584 FOG: HPt domain [Signal transduction mechanisms]; Region: ArcB; COG2198 1142394005585 putative binding surface; other site 1142394005586 active site 1142394005587 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1142394005588 GAF domain; Region: GAF; pfam01590 1142394005589 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1142394005590 PAS domain; Region: PAS_9; pfam13426 1142394005591 putative active site [active] 1142394005592 heme pocket [chemical binding]; other site 1142394005593 PAS domain S-box; Region: sensory_box; TIGR00229 1142394005594 PAS domain; Region: PAS; smart00091 1142394005595 putative active site [active] 1142394005596 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1142394005597 dimer interface [polypeptide binding]; other site 1142394005598 phosphorylation site [posttranslational modification] 1142394005599 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1142394005600 ATP binding site [chemical binding]; other site 1142394005601 Mg2+ binding site [ion binding]; other site 1142394005602 G-X-G motif; other site 1142394005603 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1142394005604 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 1142394005605 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1142394005606 minor groove reading motif; other site 1142394005607 helix-hairpin-helix signature motif; other site 1142394005608 substrate binding pocket [chemical binding]; other site 1142394005609 active site 1142394005610 Uncharacterized conserved protein [Function unknown]; Region: COG3347 1142394005611 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1142394005612 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1142394005613 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1142394005614 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1142394005615 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1142394005616 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1142394005617 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1142394005618 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1142394005619 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 1142394005620 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1142394005621 DNA binding site [nucleotide binding] 1142394005622 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1142394005623 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 1142394005624 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1142394005625 RNA polymerase beta subunit; Provisional; Region: rpoB; CHL00207 1142394005626 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1142394005627 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1142394005628 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1142394005629 RPB11 interaction site [polypeptide binding]; other site 1142394005630 RPB12 interaction site [polypeptide binding]; other site 1142394005631 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1142394005632 RPB3 interaction site [polypeptide binding]; other site 1142394005633 RPB1 interaction site [polypeptide binding]; other site 1142394005634 RPB11 interaction site [polypeptide binding]; other site 1142394005635 RPB10 interaction site [polypeptide binding]; other site 1142394005636 primosome assembly protein PriA; Validated; Region: PRK05580 1142394005637 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1142394005638 ATP binding site [chemical binding]; other site 1142394005639 putative Mg++ binding site [ion binding]; other site 1142394005640 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1142394005641 ATP-binding site [chemical binding]; other site 1142394005642 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1142394005643 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1142394005644 FMN binding site [chemical binding]; other site 1142394005645 active site 1142394005646 substrate binding site [chemical binding]; other site 1142394005647 catalytic residue [active] 1142394005648 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1142394005649 MutS domain I; Region: MutS_I; pfam01624 1142394005650 MutS domain II; Region: MutS_II; pfam05188 1142394005651 MutS domain III; Region: MutS_III; pfam05192 1142394005652 MutS domain V; Region: MutS_V; pfam00488 1142394005653 Walker A/P-loop; other site 1142394005654 ATP binding site [chemical binding]; other site 1142394005655 Q-loop/lid; other site 1142394005656 ABC transporter signature motif; other site 1142394005657 Walker B; other site 1142394005658 D-loop; other site 1142394005659 H-loop/switch region; other site 1142394005660 Domain of unknown function (DUF4174); Region: DUF4174; pfam13778 1142394005661 K+-dependent Na+/Ca+ exchanger related-protein; Region: TIGR00367 1142394005662 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1142394005663 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1142394005664 Exonuclease VII, large subunit [DNA replication, recombination, and repair]; Region: XseA; COG1570 1142394005665 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1142394005666 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1142394005667 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1142394005668 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1142394005669 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1142394005670 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1142394005671 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1142394005672 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1142394005673 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1142394005674 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1142394005675 homodimer interface [polypeptide binding]; other site 1142394005676 oligonucleotide binding site [chemical binding]; other site 1142394005677 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1142394005678 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1142394005679 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1142394005680 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1142394005681 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1142394005682 active site 1142394005683 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1142394005684 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1142394005685 RIP metalloprotease RseP; Region: TIGR00054 1142394005686 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1142394005687 protein binding site [polypeptide binding]; other site 1142394005688 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1142394005689 putative substrate binding region [chemical binding]; other site 1142394005690 Multi-copper polyphenol oxidoreductase laccase; Region: Cu-oxidase_4; cl00650 1142394005691 Thioredoxin-like domain; Region: Thioredoxin_2; pfam13098 1142394005692 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1142394005693 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1142394005694 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1142394005695 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1142394005696 catalytic residue [active] 1142394005697 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1142394005698 Sulfatase; Region: Sulfatase; cl17466 1142394005699 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1142394005700 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1142394005701 DNA-binding site [nucleotide binding]; DNA binding site 1142394005702 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1142394005703 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1142394005704 ligand binding site [chemical binding]; other site 1142394005705 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1142394005706 Uncharacterized conserved protein [Function unknown]; Region: COG1262 1142394005707 homoserine O-acetyltransferase; Provisional; Region: metX; PRK00175 1142394005708 homoserine O-acetyltransferase; Region: homoserO_Ac_trn; TIGR01392 1142394005709 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1142394005710 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3014 1142394005711 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1142394005712 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1142394005713 Walker A/P-loop; other site 1142394005714 ATP binding site [chemical binding]; other site 1142394005715 Q-loop/lid; other site 1142394005716 ABC transporter signature motif; other site 1142394005717 Walker B; other site 1142394005718 D-loop; other site 1142394005719 H-loop/switch region; other site 1142394005720 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1142394005721 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1142394005722 putative PBP binding loops; other site 1142394005723 ABC-ATPase subunit interface; other site 1142394005724 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 1142394005725 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1142394005726 Beta-lactamase; Region: Beta-lactamase; pfam00144 1142394005727 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1142394005728 Beta-lactamase; Region: Beta-lactamase; pfam00144 1142394005729 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 1142394005730 putative dimer interface [polypeptide binding]; other site 1142394005731 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 1142394005732 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1142394005733 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 1142394005734 active site 1142394005735 metal binding site [ion binding]; metal-binding site 1142394005736 RNA polymerase sigma-70 factor, TIGR02952 family; Region: Sig70_famx2 1142394005737 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1142394005738 DNA binding residues [nucleotide binding] 1142394005739 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1142394005740 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1142394005741 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1142394005742 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1142394005743 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1142394005744 6PGL: 6-Phosphogluconolactonase (6PGL) subfamily; 6PGL catalyzes the second step of the oxidative phase of the pentose phosphate pathway, the hydrolyzation of 6-phosphoglucono-1,5-lactone (delta form) to 6-phosphogluconate. 6PGL is thought to guard...; Region: 6PGL; cd01400 1142394005745 putative active site [active] 1142394005746 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1142394005747 active site 1142394005748 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cl15837 1142394005749 active site 1142394005750 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1142394005751 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1142394005752 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1142394005753 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 1142394005754 DNA binding residues [nucleotide binding] 1142394005755 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1142394005756 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1142394005757 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1142394005758 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1142394005759 extended (e) SDRs; Region: SDR_e; cd08946 1142394005760 NAD dependent epimerase/dehydratase family; Region: Epimerase; pfam01370 1142394005761 NAD(P) binding site [chemical binding]; other site 1142394005762 active site 1142394005763 substrate binding site [chemical binding]; other site 1142394005764 UDP-N-acetylmuramyl pentapeptide synthase [Cell envelope biogenesis, outer membrane]; Region: MurF; COG0770 1142394005765 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1142394005766 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1142394005767 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1142394005768 Mg++ binding site [ion binding]; other site 1142394005769 putative catalytic motif [active] 1142394005770 putative substrate binding site [chemical binding]; other site 1142394005771 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 1142394005772 classical (c) SDRs; Region: SDR_c; cd05233 1142394005773 NAD(P) binding site [chemical binding]; other site 1142394005774 active site 1142394005775 PilZ domain; Region: PilZ; pfam07238 1142394005776 PilZ domain; Region: PilZ; pfam07238 1142394005777 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1142394005778 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1142394005779 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1142394005780 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1142394005781 4Fe-4S dicluster domain; Region: Fer4_8; pfam13183 1142394005782 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 1142394005783 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1142394005784 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1142394005785 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1142394005786 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1142394005787 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 1142394005788 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1142394005789 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 1142394005790 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 1142394005791 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 1142394005792 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 1142394005793 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1142394005794 dimer interface [polypeptide binding]; other site 1142394005795 conserved gate region; other site 1142394005796 putative PBP binding loops; other site 1142394005797 ABC-ATPase subunit interface; other site 1142394005798 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1142394005799 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1142394005800 dimer interface [polypeptide binding]; other site 1142394005801 conserved gate region; other site 1142394005802 ABC-ATPase subunit interface; other site 1142394005803 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 1142394005804 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 1142394005805 substrate binding pocket [chemical binding]; other site 1142394005806 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1142394005807 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 1142394005808 Signal peptidase (SPase) II; Region: Peptidase_A8; pfam01252 1142394005809 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 1142394005810 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 1142394005811 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 1142394005812 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 1142394005813 active site 1142394005814 catalytic triad [active] 1142394005815 dimer interface [polypeptide binding]; other site 1142394005816 xanthine permease; Region: pbuX; TIGR03173 1142394005817 4-aminobutyrate aminotransferase and related aminotransferases [Amino acid transport and metabolism]; Region: GabT; COG0160 1142394005818 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1142394005819 inhibitor-cofactor binding pocket; inhibition site 1142394005820 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1142394005821 catalytic residue [active] 1142394005822 oxidoreductase, acting on the CH-CH group of donors; Region: PLN02495 1142394005823 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 1142394005824 homodimer interface [polypeptide binding]; other site 1142394005825 active site 1142394005826 FMN binding site [chemical binding]; other site 1142394005827 substrate binding site [chemical binding]; other site 1142394005828 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1142394005829 Formyltransferase, catalytic core domain; Region: FMT_core; cd08369 1142394005830 active site 1142394005831 cosubstrate binding site; other site 1142394005832 substrate binding site [chemical binding]; other site 1142394005833 catalytic site [active] 1142394005834 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1142394005835 This family is most closely related to the GT1 family of glycosyltransferases. mtfB (mannosyltransferase B) in E. coli has been shown to direct the growth of the O9-specific polysaccharide chain. It transfers two mannoses into the position 3 of the...; Region: GT1_mtfB_like; cd03809 1142394005836 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1142394005837 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1142394005838 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1142394005839 inhibitor-cofactor binding pocket; inhibition site 1142394005840 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1142394005841 catalytic residue [active] 1142394005842 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1142394005843 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1142394005844 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1142394005845 active site 1142394005846 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1142394005847 active site 1142394005848 nucleotide binding site [chemical binding]; other site 1142394005849 HIGH motif; other site 1142394005850 KMSKS motif; other site 1142394005851 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1142394005852 ATP binding site [chemical binding]; other site 1142394005853 substrate binding site [chemical binding]; other site 1142394005854 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 1142394005855 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 1142394005856 Probable Catalytic site; other site 1142394005857 metal-binding site 1142394005858 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 1142394005859 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1142394005860 Walker A motif; other site 1142394005861 ATP binding site [chemical binding]; other site 1142394005862 Walker B motif; other site 1142394005863 arginine finger; other site 1142394005864 Peptidase family M41; Region: Peptidase_M41; pfam01434 1142394005865 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1142394005866 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1142394005867 ABC-type sugar transport systems, permease components [Carbohydrate transport and metabolism]; Region: UgpA; COG1175 1142394005868 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1142394005869 putative PBP binding loops; other site 1142394005870 dimer interface [polypeptide binding]; other site 1142394005871 ABC-ATPase subunit interface; other site 1142394005872 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1142394005873 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1142394005874 dimer interface [polypeptide binding]; other site 1142394005875 conserved gate region; other site 1142394005876 putative PBP binding loops; other site 1142394005877 ABC-ATPase subunit interface; other site 1142394005878 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 1142394005879 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1142394005880 DNA-binding site [nucleotide binding]; DNA binding site 1142394005881 FCD domain; Region: FCD; pfam07729 1142394005882 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 1142394005883 Cellulase (glycosyl hydrolase family 5); Region: Cellulase; pfam00150 1142394005884 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1142394005885 MFS/sugar transport protein; Region: MFS_2; pfam13347 1142394005886 Family description; Region: VCBS; pfam13517 1142394005887 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 1142394005888 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 1142394005889 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 1142394005890 active site pocket [active] 1142394005891 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1142394005892 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1142394005893 NAD(P) binding site [chemical binding]; other site 1142394005894 catalytic residues [active] 1142394005895 2-deoxy-D-gluconate 3-dehydrogenase; Region: kduD; TIGR01832 1142394005896 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1142394005897 NADP binding site [chemical binding]; other site 1142394005898 homodimer interface [polypeptide binding]; other site 1142394005899 active site 1142394005900 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1142394005901 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1142394005902 NAD(P) binding site [chemical binding]; other site 1142394005903 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1142394005904 active site 1142394005905 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 1142394005906 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1142394005907 domain interfaces; other site 1142394005908 active site 1142394005909 PrcB C-terminal; Region: PrcB_C; pfam14343 1142394005910 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1142394005911 S-adenosylmethionine binding site [chemical binding]; other site 1142394005912 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1142394005913 DNA binding residues [nucleotide binding] 1142394005914 B12 binding domain; Region: B12-binding_2; pfam02607 1142394005915 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 1142394005916 B12 binding site [chemical binding]; other site 1142394005917 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK12305 1142394005918 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1142394005919 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1142394005920 active site 1142394005921 dimer interface [polypeptide binding]; other site 1142394005922 motif 1; other site 1142394005923 motif 2; other site 1142394005924 motif 3; other site 1142394005925 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1142394005926 anticodon binding site; other site 1142394005927 Transposase IS200 like; Region: Y1_Tnp; cl00848 1142394005928 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1142394005929 AAA domain; Region: AAA_12; pfam13087 1142394005930 Family description; Region: UvrD_C_2; pfam13538 1142394005931 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 1142394005932 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1142394005933 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_15; cd07264 1142394005934 putative GTP cyclohydrolase; Provisional; Region: PRK13674 1142394005935 H+ Antiporter protein; Region: 2A0121; TIGR00900 1142394005936 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1142394005937 putative substrate translocation pore; other site 1142394005938 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1142394005939 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1142394005940 putative acyl-acceptor binding pocket; other site 1142394005941 Copper binding periplasmic protein CusF; Region: CusF_Ec; cl02363 1142394005942 ADP-L-glycero-D-manno-heptose-6-epimerase; Region: heptose_epim; TIGR02197 1142394005943 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1142394005944 NAD(P) binding site [chemical binding]; other site 1142394005945 active site 1142394005946 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1142394005947 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1142394005948 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 1142394005949 FOG: CBS domain [General function prediction only]; Region: COG0517 1142394005950 ScpA/B protein; Region: ScpA_ScpB; cl00598 1142394005951 Gram-negative bacterial tonB protein; Region: TonB; cl10048 1142394005952 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1142394005953 core domain interface [polypeptide binding]; other site 1142394005954 delta subunit interface [polypeptide binding]; other site 1142394005955 epsilon subunit interface [polypeptide binding]; other site 1142394005956 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 1142394005957 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1142394005958 active site 1142394005959 Fructosamine kinase; Region: Fructosamin_kin; cl17579 1142394005960 MoxR-like ATPases [General function prediction only]; Region: COG0714 1142394005961 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1142394005962 Walker A motif; other site 1142394005963 ATP binding site [chemical binding]; other site 1142394005964 Walker B motif; other site 1142394005965 arginine finger; other site 1142394005966 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1142394005967 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1142394005968 Walker A/P-loop; other site 1142394005969 ATP binding site [chemical binding]; other site 1142394005970 Q-loop/lid; other site 1142394005971 ABC transporter signature motif; other site 1142394005972 Walker B; other site 1142394005973 D-loop; other site 1142394005974 H-loop/switch region; other site 1142394005975 Protein of unknown function DUF58; Region: DUF58; pfam01882 1142394005976 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 1142394005977 metal ion-dependent adhesion site (MIDAS); other site 1142394005978 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: Phd; COG4118 1142394005979 PIN domain of the VapC-like Sll0205 protein and homologs; Region: PIN_Sll0205; cd09872 1142394005980 putative active site [active] 1142394005981 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1142394005982 DNA-binding site [nucleotide binding]; DNA binding site 1142394005983 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 1142394005984 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1142394005985 Walker A/P-loop; other site 1142394005986 ATP binding site [chemical binding]; other site 1142394005987 Q-loop/lid; other site 1142394005988 ABC transporter signature motif; other site 1142394005989 Walker B; other site 1142394005990 D-loop; other site 1142394005991 H-loop/switch region; other site 1142394005992 CHASE domain; Region: CHASE; pfam03924 1142394005993 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1142394005994 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1142394005995 metal binding site [ion binding]; metal-binding site 1142394005996 active site 1142394005997 I-site; other site 1142394005998 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1142394005999 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1142394006000 NlpC/P60 family; Region: NLPC_P60; cl17555 1142394006001 Fatty acid desaturase; Region: FA_desaturase; pfam00487 1142394006002 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1142394006003 Di-iron ligands [ion binding]; other site 1142394006004 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 1142394006005 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1142394006006 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1142394006007 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1142394006008 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1142394006009 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1142394006010 Walker A motif; other site 1142394006011 ATP binding site [chemical binding]; other site 1142394006012 Walker B motif; other site 1142394006013 Haemolytic domain; Region: Haemolytic; pfam01809 1142394006014 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cl00338 1142394006015 dimer interface [polypeptide binding]; other site 1142394006016 active site 1142394006017 Schiff base residues; other site 1142394006018 GAF domain; Region: GAF_2; pfam13185 1142394006019 GAF domain; Region: GAF; pfam01590 1142394006020 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1142394006021 active site 1142394006022 I-site; other site 1142394006023 metal binding site [ion binding]; metal-binding site 1142394006024 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1142394006025 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 1142394006026 active site 1142394006027 3-ketoacyl-(acyl-carrier-protein) reductase; Reviewed; Region: PRK12826 1142394006028 classical (c) SDRs; Region: SDR_c; cd05233 1142394006029 NAD(P) binding site [chemical binding]; other site 1142394006030 active site 1142394006031 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 1142394006032 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1142394006033 ATP binding site [chemical binding]; other site 1142394006034 putative Mg++ binding site [ion binding]; other site 1142394006035 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1142394006036 nucleotide binding region [chemical binding]; other site 1142394006037 ATP-binding site [chemical binding]; other site 1142394006038 Helicase associated domain (HA2); Region: HA2; pfam04408 1142394006039 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1142394006040 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1142394006041 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 1142394006042 Galactose oxidase, central domain; Region: Kelch_3; cl02701 1142394006043 Kelch motif; Region: Kelch_6; pfam13964 1142394006044 Domain of unknown function (DUF386); Region: DUF386; cl01047 1142394006045 ATP-utilizing enzymes of the PP-loop superfamily [General function prediction only]; Region: COG1606 1142394006046 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 1142394006047 Ligand Binding Site [chemical binding]; other site 1142394006048 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 1142394006049 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 1142394006050 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 1142394006051 ADP binding site [chemical binding]; other site 1142394006052 phosphagen binding site; other site 1142394006053 substrate specificity loop; other site 1142394006054 recombination protein RecR; Reviewed; Region: recR; PRK00076 1142394006055 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1142394006056 putative active site [active] 1142394006057 putative metal-binding site [ion binding]; other site 1142394006058 tetramer interface [polypeptide binding]; other site 1142394006059 Glyoxalase-like domain; Region: Glyoxalase_3; pfam13468 1142394006060 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 1142394006061 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1142394006062 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1142394006063 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1142394006064 active site 1142394006065 dimer interface [polypeptide binding]; other site 1142394006066 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1142394006067 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1142394006068 active site 1142394006069 FMN binding site [chemical binding]; other site 1142394006070 substrate binding site [chemical binding]; other site 1142394006071 3Fe-4S cluster binding site [ion binding]; other site 1142394006072 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1142394006073 domain interface; other site 1142394006074 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1142394006075 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1142394006076 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1142394006077 dimerization interface [polypeptide binding]; other site 1142394006078 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1142394006079 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1142394006080 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1142394006081 S-adenosylmethionine binding site [chemical binding]; other site 1142394006082 Trm112p-like protein; Region: Trm112p; cl01066 1142394006083 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1142394006084 Na binding site [ion binding]; other site 1142394006085 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1142394006086 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1142394006087 active site 1142394006088 ATP binding site [chemical binding]; other site 1142394006089 substrate binding site [chemical binding]; other site 1142394006090 activation loop (A-loop); other site 1142394006091 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1142394006092 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1142394006093 Substrate binding site; other site 1142394006094 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1142394006095 Mg++ binding site; other site 1142394006096 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1142394006097 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1142394006098 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1142394006099 active site 1142394006100 50S ribosomal protein L25/general stress protein Ctc; Reviewed; Region: PRK05618 1142394006101 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1142394006102 5S rRNA interface [nucleotide binding]; other site 1142394006103 CTC domain interface [polypeptide binding]; other site 1142394006104 L16 interface [polypeptide binding]; other site 1142394006105 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1142394006106 putative active site [active] 1142394006107 catalytic residue [active] 1142394006108 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1142394006109 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1142394006110 active site 1142394006111 substrate-binding site [chemical binding]; other site 1142394006112 metal-binding site [ion binding] 1142394006113 ATP binding site [chemical binding]; other site 1142394006114 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1142394006115 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1142394006116 substrate binding site [chemical binding]; other site 1142394006117 glutamase interaction surface [polypeptide binding]; other site 1142394006118 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 1142394006119 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1142394006120 active site 1142394006121 dimer interface [polypeptide binding]; other site 1142394006122 metal binding site [ion binding]; metal-binding site 1142394006123 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1142394006124 Strictosidine synthase; Region: Str_synth; pfam03088 1142394006125 histidinol-phosphate phosphatase family domain; Region: Histidinol-ppas; TIGR01656 1142394006126 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1142394006127 active site 1142394006128 motif I; other site 1142394006129 motif II; other site 1142394006130 Guanylate kinase; Region: Guanylate_kin; pfam00625 1142394006131 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1142394006132 catalytic site [active] 1142394006133 G-X2-G-X-G-K; other site 1142394006134 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1142394006135 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1142394006136 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1142394006137 NAD(P) binding site [chemical binding]; other site 1142394006138 active site 1142394006139 Putative D-isomer specific 2-hydroxyacid dehydrogenases; Region: 2-Hacid_dh_4; cd12162 1142394006140 glycerate dehydrogenase; Provisional; Region: PRK06487 1142394006141 putative ligand binding site [chemical binding]; other site 1142394006142 putative NAD binding site [chemical binding]; other site 1142394006143 catalytic site [active] 1142394006144 ribose-5-phosphate isomerase B; Provisional; Region: PRK05571 1142394006145 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 1142394006146 2-isopropylmalate synthase; Validated; Region: PRK00915 1142394006147 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1142394006148 active site 1142394006149 catalytic residues [active] 1142394006150 metal binding site [ion binding]; metal-binding site 1142394006151 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 1142394006152 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1142394006153 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 1142394006154 putative metal binding site; other site 1142394006155 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1142394006156 S17 interaction site [polypeptide binding]; other site 1142394006157 S8 interaction site; other site 1142394006158 16S rRNA interaction site [nucleotide binding]; other site 1142394006159 streptomycin interaction site [chemical binding]; other site 1142394006160 23S rRNA interaction site [nucleotide binding]; other site 1142394006161 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1142394006162 30S ribosomal protein S7; Validated; Region: PRK05302 1142394006163 Flagellar L-ring protein; Region: FlgH; cl17277 1142394006164 SAF-like; Region: SAF_2; pfam13144 1142394006165 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1142394006166 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1142394006167 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1142394006168 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1142394006169 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 1142394006170 Beta-lactamase; Region: Beta-lactamase; pfam00144 1142394006171 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1142394006172 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1142394006173 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 1142394006174 RNA binding site [nucleotide binding]; other site 1142394006175 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1142394006176 RNA binding site [nucleotide binding]; other site 1142394006177 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1142394006178 RNA binding site [nucleotide binding]; other site 1142394006179 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1142394006180 RNA binding site [nucleotide binding]; other site 1142394006181 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 1142394006182 RNA binding site [nucleotide binding]; other site 1142394006183 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 1142394006184 RNA binding site [nucleotide binding]; other site 1142394006185 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4337 1142394006186 arginine decarboxylase; Provisional; Region: PRK05354 1142394006187 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1142394006188 dimer interface [polypeptide binding]; other site 1142394006189 active site 1142394006190 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1142394006191 catalytic residues [active] 1142394006192 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1142394006193 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 1142394006194 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 1142394006195 GatB domain; Region: GatB_Yqey; pfam02637 1142394006196 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1142394006197 active site 1142394006198 Chlorite dismutase; Region: Chlor_dismutase; cl01280 1142394006199 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1142394006200 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1142394006201 active site 1142394006202 phosphorylation site [posttranslational modification] 1142394006203 intermolecular recognition site; other site 1142394006204 dimerization interface [polypeptide binding]; other site 1142394006205 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1142394006206 DNA binding residues [nucleotide binding] 1142394006207 dimerization interface [polypeptide binding]; other site 1142394006208 ABC-2 type transporter; Region: ABC2_membrane; cl17235 1142394006209 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1142394006210 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1142394006211 Uncharacterized protein SCO1/SenC/PrrC, involved in biogenesis of respiratory and photosynthetic systems [General function prediction only]; Region: COG1999 1142394006212 Cu(I) binding site [ion binding]; other site 1142394006213 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1142394006214 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1142394006215 dimerization interface [polypeptide binding]; other site 1142394006216 active site 1142394006217 Domain of unknown function (DUF389); Region: DUF389; pfam04087 1142394006218 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1142394006219 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1142394006220 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1142394006221 putative active site [active] 1142394006222 catalytic site [active] 1142394006223 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 1142394006224 putative active site [active] 1142394006225 catalytic site [active] 1142394006226 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1142394006227 30S subunit binding site; other site 1142394006228 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 1142394006229 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1142394006230 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1142394006231 Walker A motif; other site 1142394006232 ATP binding site [chemical binding]; other site 1142394006233 Walker B motif; other site 1142394006234 arginine finger; other site 1142394006235 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1142394006236 Helix-turn-helix domain; Region: HTH_17; pfam12728 1142394006237 Domain of unknown function (DUF329); Region: DUF329; cl01144 1142394006238 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 1142394006239 thiamine monophosphate kinase; Provisional; Region: PRK05731 1142394006240 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1142394006241 ATP binding site [chemical binding]; other site 1142394006242 dimerization interface [polypeptide binding]; other site 1142394006243 Protein of unknown function (DUF3553); Region: DUF3553; pfam12073 1142394006244 Ligase N family; Region: LIGANc; smart00532 1142394006245 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1142394006246 nucleotide binding pocket [chemical binding]; other site 1142394006247 K-X-D-G motif; other site 1142394006248 catalytic site [active] 1142394006249 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1142394006250 Helix-hairpin-helix motif; Region: HHH_2; pfam12826 1142394006251 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1142394006252 Dimer interface [polypeptide binding]; other site 1142394006253 BRCT sequence motif; other site 1142394006254 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 1142394006255 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1142394006256 Pilus assembly protein, PilO; Region: PilO; cl01234 1142394006257 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1142394006258 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1142394006259 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1142394006260 Walker A motif; other site 1142394006261 ATP binding site [chemical binding]; other site 1142394006262 Walker B motif; other site 1142394006263 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1142394006264 putative active site [active] 1142394006265 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1142394006266 nucleoside/Zn binding site; other site 1142394006267 dimer interface [polypeptide binding]; other site 1142394006268 catalytic motif [active] 1142394006269 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1142394006270 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1142394006271 intersubunit interface [polypeptide binding]; other site 1142394006272 active site 1142394006273 catalytic residue [active] 1142394006274 SpoIVFB Site-2 protease (S2P), a zinc metalloprotease (MEROPS family M50B), regulates intramembrane proteolysis (RIP), and is involved in the pro-sigmaK pathway of bacterial spore formation. In this subgroup, SpoIVFB (sporulation protein, stage IV cell...; Region: S2P-M50_SpoIVFB_CBS; cd06164 1142394006275 Peptidase family M50; Region: Peptidase_M50; pfam02163 1142394006276 active site 1142394006277 putative substrate binding region [chemical binding]; other site 1142394006278 Virulence factor BrkB; Region: Virul_fac_BrkB; pfam03631 1142394006279 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1142394006280 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1142394006281 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1142394006282 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1142394006283 NAD(P) binding site [chemical binding]; other site 1142394006284 active site 1142394006285 Right handed beta helix region; Region: Beta_helix; pfam13229 1142394006286 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1142394006287 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1142394006288 Ribonuclease P; Region: Ribonuclease_P; pfam00825 1142394006289 potential protein location (hypothetical protein PSMK_27110 [Phycisphaera mikurensis NBRC 102666]) that overlaps RNA (tRNA-H) 1142394006290 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1142394006291 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1142394006292 RNA binding surface [nucleotide binding]; other site 1142394006293 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1142394006294 active site 1142394006295 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1142394006296 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1142394006297 DNA binding site [nucleotide binding] 1142394006298 domain linker motif; other site 1142394006299 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1142394006300 dimerization interface [polypeptide binding]; other site 1142394006301 ligand binding site [chemical binding]; other site 1142394006302 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 1142394006303 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 1142394006304 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 1142394006305 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 1142394006306 Homeodomain-like domain; Region: HTH_23; cl17451 1142394006307 Winged helix-turn helix; Region: HTH_29; pfam13551 1142394006308 Homeodomain-like domain; Region: HTH_32; pfam13565 1142394006309 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1142394006310 Protein of unknown function (DUF971); Region: DUF971; pfam06155 1142394006311 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 1142394006312 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1142394006313 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1142394006314 active site 1142394006315 phosphorylation site [posttranslational modification] 1142394006316 intermolecular recognition site; other site 1142394006317 dimerization interface [polypeptide binding]; other site 1142394006318 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1142394006319 DNA binding site [nucleotide binding] 1142394006320 PAS fold; Region: PAS_4; pfam08448 1142394006321 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1142394006322 putative active site [active] 1142394006323 heme pocket [chemical binding]; other site 1142394006324 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1142394006325 dimer interface [polypeptide binding]; other site 1142394006326 phosphorylation site [posttranslational modification] 1142394006327 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1142394006328 Mg2+ binding site [ion binding]; other site 1142394006329 G-X-G motif; other site 1142394006330 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 1142394006331 PhoU domain; Region: PhoU; pfam01895 1142394006332 PhoU domain; Region: PhoU; pfam01895 1142394006333 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1142394006334 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1142394006335 DNA binding site [nucleotide binding] 1142394006336 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1142394006337 ligand binding site [chemical binding]; other site 1142394006338 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 1142394006339 Sensory domain found in PocR; Region: PocR; pfam10114 1142394006340 GAF domain; Region: GAF; pfam01590 1142394006341 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 1142394006342 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1142394006343 Domain of unknown function DUF21; Region: DUF21; pfam01595 1142394006344 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1142394006345 Domain of unknown function DUF21; Region: DUF21; pfam01595 1142394006346 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1142394006347 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1142394006348 Transporter associated domain; Region: CorC_HlyC; smart01091 1142394006349 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 1142394006350 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 1142394006351 active site 1142394006352 substrate binding site [chemical binding]; other site 1142394006353 metal binding site [ion binding]; metal-binding site 1142394006354 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1142394006355 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1142394006356 motif II; other site 1142394006357 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 1142394006358 DNA binding residues [nucleotide binding] 1142394006359 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1142394006360 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1142394006361 active site 1142394006362 phosphorylation site [posttranslational modification] 1142394006363 intermolecular recognition site; other site 1142394006364 dimerization interface [polypeptide binding]; other site 1142394006365 CTP synthetase; Validated; Region: pyrG; PRK05380 1142394006366 CTP synthase N-terminus; Region: CTP_synth_N; pfam06418 1142394006367 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1142394006368 active site 1142394006369 putative oxyanion hole; other site 1142394006370 catalytic triad [active] 1142394006371 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 1142394006372 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1142394006373 ligand binding site [chemical binding]; other site 1142394006374 flexible hinge region; other site 1142394006375 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 1142394006376 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1142394006377 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1142394006378 ACT domain-containing protein [General function prediction only]; Region: COG4747 1142394006379 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1142394006380 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1142394006381 CCC1-related family of proteins; Region: CCC1_like; cl00278 1142394006382 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 1142394006383 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1142394006384 FMN binding site [chemical binding]; other site 1142394006385 active site 1142394006386 catalytic residues [active] 1142394006387 substrate binding site [chemical binding]; other site 1142394006388 Glucose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: Pgi; COG0166 1142394006389 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1142394006390 active site 1142394006391 dimer interface [polypeptide binding]; other site 1142394006392 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1142394006393 dimer interface [polypeptide binding]; other site 1142394006394 active site 1142394006395 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1142394006396 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1142394006397 Walker A/P-loop; other site 1142394006398 ATP binding site [chemical binding]; other site 1142394006399 Q-loop/lid; other site 1142394006400 ABC transporter signature motif; other site 1142394006401 Walker B; other site 1142394006402 D-loop; other site 1142394006403 H-loop/switch region; other site 1142394006404 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1142394006405 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1142394006406 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1142394006407 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1142394006408 putative active site [active] 1142394006409 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1142394006410 Ca2+/Na+ antiporter [Inorganic ion transport and metabolism]; Region: ECM27; COG0530 1142394006411 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1142394006412 Putative transmembrane protein (PGPGW); Region: PGPGW; pfam09656 1142394006413 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 1142394006414 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1142394006415 lipoic acid synthase; Region: PLN02428 1142394006416 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1142394006417 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1142394006418 dimerization interface 3.5A [polypeptide binding]; other site 1142394006419 active site 1142394006420 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1142394006421 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 1142394006422 putative ADP-binding pocket [chemical binding]; other site 1142394006423 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 1142394006424 1-deoxy-D-xylulose-5-phosphate synthase; Region: DXP_synthase_N; pfam13292 1142394006425 TPP-binding site [chemical binding]; other site 1142394006426 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1142394006427 PYR/PP interface [polypeptide binding]; other site 1142394006428 dimer interface [polypeptide binding]; other site 1142394006429 TPP binding site [chemical binding]; other site 1142394006430 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1142394006431 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1142394006432 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1142394006433 substrate binding pocket [chemical binding]; other site 1142394006434 chain length determination region; other site 1142394006435 substrate-Mg2+ binding site; other site 1142394006436 catalytic residues [active] 1142394006437 aspartate-rich region 1; other site 1142394006438 active site lid residues [active] 1142394006439 aspartate-rich region 2; other site 1142394006440 helicase 45; Provisional; Region: PTZ00424 1142394006441 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1142394006442 ATP binding site [chemical binding]; other site 1142394006443 Mg++ binding site [ion binding]; other site 1142394006444 motif III; other site 1142394006445 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1142394006446 nucleotide binding region [chemical binding]; other site 1142394006447 ATP-binding site [chemical binding]; other site 1142394006448 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1142394006449 putative RNA binding site [nucleotide binding]; other site 1142394006450 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1142394006451 Eukaryotic initiation factor 1 and related proteins; Region: eIF1_SUI1_like; cl00229 1142394006452 putative rRNA binding site [nucleotide binding]; other site 1142394006453 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1142394006454 amphipathic channel; other site 1142394006455 Asn-Pro-Ala signature motifs; other site 1142394006456 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 1142394006457 MOSC domain; Region: MOSC; pfam03473 1142394006458 urea ABC transporter, ATP-binding protein UrtE; Region: urea_trans_UrtE; TIGR03410 1142394006459 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1142394006460 Walker A/P-loop; other site 1142394006461 ATP binding site [chemical binding]; other site 1142394006462 Q-loop/lid; other site 1142394006463 ABC transporter signature motif; other site 1142394006464 Walker B; other site 1142394006465 D-loop; other site 1142394006466 H-loop/switch region; other site 1142394006467 urea ABC transporter, ATP-binding protein UrtD; Region: urea_trans_UrtD; TIGR03411 1142394006468 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1142394006469 Walker A/P-loop; other site 1142394006470 ATP binding site [chemical binding]; other site 1142394006471 Q-loop/lid; other site 1142394006472 ABC transporter signature motif; other site 1142394006473 Walker B; other site 1142394006474 D-loop; other site 1142394006475 H-loop/switch region; other site 1142394006476 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1142394006477 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1142394006478 TM-ABC transporter signature motif; other site 1142394006479 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1142394006480 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1142394006481 TM-ABC transporter signature motif; other site 1142394006482 Periplasmic binding protein; Region: Peripla_BP_6; pfam13458 1142394006483 Periplasmic component (FmdD) of an active transport system for short-chain amides and urea (FmdDEF); Region: PBP1_FmdD_like; cd06355 1142394006484 putative ligand binding site [chemical binding]; other site 1142394006485 Putative regulatory protein; Region: CxxC_CXXC_SSSS; smart00834 1142394006486 Acetamidase/Formamidase family; Region: FmdA_AmdA; pfam03069 1142394006487 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1142394006488 N-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_N_like; cd08346 1142394006489 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1142394006490 Zn binding site [ion binding]; other site 1142394006491 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1142394006492 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1142394006493 Zn binding site [ion binding]; other site 1142394006494 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1142394006495 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1142394006496 MarR family; Region: MarR_2; cl17246 1142394006497 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 1142394006498 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1142394006499 active site 1142394006500 metal binding site [ion binding]; metal-binding site 1142394006501 C-terminal domain of Sphingobium chlorophenolicum 2,6-dichloro-p-hydroquinone 1,2-dioxygenase (PcpA), and similar proteins; Region: PcpA_C_like; cd08347 1142394006502 Zn binding site [ion binding]; other site 1142394006503 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1142394006504 dimer interface [polypeptide binding]; other site 1142394006505 active site 1142394006506 ADP-ribose binding site [chemical binding]; other site 1142394006507 nudix motif; other site 1142394006508 metal binding site [ion binding]; metal-binding site 1142394006509 Entner-Doudoroff aldolase; Region: eda; TIGR01182 1142394006510 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1142394006511 active site 1142394006512 intersubunit interface [polypeptide binding]; other site 1142394006513 catalytic residue [active] 1142394006514 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1142394006515 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1142394006516 substrate binding site [chemical binding]; other site 1142394006517 ATP binding site [chemical binding]; other site 1142394006518 DNA topoisomerase I; Validated; Region: PRK06599 1142394006519 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1142394006520 active site 1142394006521 interdomain interaction site; other site 1142394006522 putative metal-binding site [ion binding]; other site 1142394006523 nucleotide binding site [chemical binding]; other site 1142394006524 Bacterial DNA topoisomeraes I ATP-binding domain; Region: TOP1Bc; smart00436 1142394006525 domain I; other site 1142394006526 phosphate binding site [ion binding]; other site 1142394006527 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1142394006528 domain II; other site 1142394006529 domain III; other site 1142394006530 nucleotide binding site [chemical binding]; other site 1142394006531 DNA binding groove [nucleotide binding] 1142394006532 catalytic site [active] 1142394006533 domain IV; other site 1142394006534 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1142394006535 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1142394006536 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1142394006537 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1142394006538 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1142394006539 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1142394006540 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1142394006541 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1142394006542 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1142394006543 Macro domain, Poa1p_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly ADP-ribose...; Region: Macro_Poa1p_like; cd02901 1142394006544 ADP-ribose binding site [chemical binding]; other site 1142394006545 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1142394006546 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1142394006547 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1142394006548 ATP binding site [chemical binding]; other site 1142394006549 putative Mg++ binding site [ion binding]; other site 1142394006550 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 1142394006551 Sulfatase; Region: Sulfatase; cl17466 1142394006552 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1142394006553 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 1142394006554 DinB family; Region: DinB; cl17821 1142394006555 DinB superfamily; Region: DinB_2; pfam12867 1142394006556 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1142394006557 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1142394006558 Walker A/P-loop; other site 1142394006559 ATP binding site [chemical binding]; other site 1142394006560 Q-loop/lid; other site 1142394006561 ABC transporter signature motif; other site 1142394006562 Walker B; other site 1142394006563 D-loop; other site 1142394006564 H-loop/switch region; other site 1142394006565 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 1142394006566 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1142394006567 active site 1142394006568 phosphorylation site [posttranslational modification] 1142394006569 intermolecular recognition site; other site 1142394006570 dimerization interface [polypeptide binding]; other site 1142394006571 hypothetical protein; Provisional; Region: PRK10557 1142394006572 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1142394006573 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 1142394006574 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1142394006575 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1142394006576 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 1142394006577 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1142394006578 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1142394006579 Walker A motif; other site 1142394006580 ATP binding site [chemical binding]; other site 1142394006581 Walker B motif; other site 1142394006582 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1142394006583 anti sigma factor interaction site; other site 1142394006584 regulatory phosphorylation site [posttranslational modification]; other site 1142394006585 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1142394006586 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1142394006587 dimer interface [polypeptide binding]; other site 1142394006588 phosphorylation site [posttranslational modification] 1142394006589 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1142394006590 ATP binding site [chemical binding]; other site 1142394006591 Mg2+ binding site [ion binding]; other site 1142394006592 G-X-G motif; other site 1142394006593 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1142394006594 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1142394006595 Peptidase family M48; Region: Peptidase_M48; cl12018 1142394006596 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 1142394006597 Bax inhibitor 1 like; Region: BaxI_1; cl17691 1142394006598 Right handed beta helix region; Region: Beta_helix; pfam13229 1142394006599 site-specific tyrosine recombinase XerC; Reviewed; Region: xerC; PRK00236 1142394006600 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1142394006601 active site 1142394006602 DNA binding site [nucleotide binding] 1142394006603 Int/Topo IB signature motif; other site 1142394006604 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 1142394006605 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1142394006606 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1142394006607 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1142394006608 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1142394006609 active site 1142394006610 The (Largely Archaeal Putative) Hydrophobe/Amphiphile Efflux-3 (HAE3) Family; Region: 2A067; TIGR00921 1142394006611 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 1142394006612 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1142394006613 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1142394006614 metal binding site [ion binding]; metal-binding site 1142394006615 substrate binding site [chemical binding]; other site 1142394006616 hexamer interface [polypeptide binding]; other site 1142394006617 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1142394006618 DNA repair protein radc; Region: radc; TIGR00608 1142394006619 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1142394006620 MPN+ (JAMM) motif; other site 1142394006621 Zinc-binding site [ion binding]; other site 1142394006622 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 1142394006623 FAD binding pocket [chemical binding]; other site 1142394006624 conserved FAD binding motif [chemical binding]; other site 1142394006625 phosphate binding motif [ion binding]; other site 1142394006626 beta-alpha-beta structure motif; other site 1142394006627 NAD binding pocket [chemical binding]; other site 1142394006628 CAAX protease self-immunity; Region: Abi; pfam02517 1142394006629 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1142394006630 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1142394006631 active site 1142394006632 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1142394006633 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1142394006634 hinge; other site 1142394006635 active site 1142394006636 Bacterial protein of unknown function (DUF937); Region: DUF937; cl01528 1142394006637 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 1142394006638 putative active site [active] 1142394006639 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 1142394006640 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1142394006641 catalytic motif [active] 1142394006642 Zn binding site [ion binding]; other site 1142394006643 RibD C-terminal domain; Region: RibD_C; cl17279 1142394006644 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1142394006645 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 1142394006646 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1142394006647 ATP binding site [chemical binding]; other site 1142394006648 putative Mg++ binding site [ion binding]; other site 1142394006649 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1142394006650 nucleotide binding region [chemical binding]; other site 1142394006651 ATP-binding site [chemical binding]; other site 1142394006652 quinolinate synthetase; Provisional; Region: PRK09375 1142394006653 Ion transport protein; Region: Ion_trans; pfam00520 1142394006654 Ion channel; Region: Ion_trans_2; pfam07885 1142394006655 Double zinc ribbon; Region: DZR; pfam12773 1142394006656 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 1142394006657 Clp protease; Region: CLP_protease; pfam00574 1142394006658 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1142394006659 oligomer interface [polypeptide binding]; other site 1142394006660 active site residues [active] 1142394006661 cell division protein GpsB; Provisional; Region: PRK14127 1142394006662 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1142394006663 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1142394006664 nucleotide binding site [chemical binding]; other site 1142394006665 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1142394006666 dimer interface [polypeptide binding]; other site 1142394006667 active site 1142394006668 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1142394006669 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1142394006670 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 1142394006671 Na binding site [ion binding]; other site 1142394006672 Predicted membrane protein [Function unknown]; Region: COG1238 1142394006673 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 1142394006674 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1142394006675 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1142394006676 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 1142394006677 active site 1142394006678 catalytic residues [active] 1142394006679 haloacid dehalogenase-like hydrolase; Region: Hydrolase_3; pfam08282 1142394006680 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1142394006681 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1142394006682 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1142394006683 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 1142394006684 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1142394006685 Catalytic site [active] 1142394006686 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1142394006687 Domain of unknown function (DUF1802); Region: DUF1802; cl01755 1142394006688 Protein of unknown function (DUF501); Region: DUF501; cl00652 1142394006689 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 1142394006690 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1142394006691 NAD binding site [chemical binding]; other site 1142394006692 putative substrate binding site 2 [chemical binding]; other site 1142394006693 putative substrate binding site 1 [chemical binding]; other site 1142394006694 active site 1142394006695 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1142394006696 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 1142394006697 active site 1142394006698 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1142394006699 active site 1142394006700 substrate binding site [chemical binding]; other site 1142394006701 ATP binding site [chemical binding]; other site 1142394006702 Phosphotransferase enzyme family; Region: APH; pfam01636 1142394006703 PDZ domain (Also known as DHR or GLGF); Region: PDZ; pfam00595 1142394006704 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 1142394006705 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 1142394006706 Predicted transcriptional regulators [Transcription]; Region: COG1510 1142394006707 MarR family; Region: MarR_2; pfam12802 1142394006708 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1142394006709 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 1142394006710 oligomer interface [polypeptide binding]; other site 1142394006711 metal binding site [ion binding]; metal-binding site 1142394006712 metal binding site [ion binding]; metal-binding site 1142394006713 Cl binding site [ion binding]; other site 1142394006714 aspartate ring; other site 1142394006715 basic sphincter; other site 1142394006716 putative hydrophobic gate; other site 1142394006717 periplasmic entrance; other site 1142394006718 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1142394006719 N- and C-terminal domain interface [polypeptide binding]; other site 1142394006720 D-xylulose kinase; Region: XylB; TIGR01312 1142394006721 active site 1142394006722 MgATP binding site [chemical binding]; other site 1142394006723 catalytic site [active] 1142394006724 metal binding site [ion binding]; metal-binding site 1142394006725 xylulose binding site [chemical binding]; other site 1142394006726 homodimer interface [polypeptide binding]; other site 1142394006727 Peptidase family M48; Region: Peptidase_M48; pfam01435 1142394006728 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1142394006729 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 1142394006730 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 1142394006731 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1142394006732 NAD(P) binding site [chemical binding]; other site 1142394006733 active site 1142394006734 Medium chain dehydrogenases/reductase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR7; cd08276 1142394006735 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 1142394006736 putative NAD(P) binding site [chemical binding]; other site 1142394006737 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1142394006738 dimerization interface [polypeptide binding]; other site 1142394006739 putative DNA binding site [nucleotide binding]; other site 1142394006740 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1142394006741 Glycosyl hydrolase families: GH43, GH62, GH32, GH68; Region: GH43_62_32_68; cl14647 1142394006742 ATPase involved in DNA repair; Region: DUF3686; pfam12458 1142394006743 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1142394006744 Walker A motif; other site 1142394006745 ATP binding site [chemical binding]; other site 1142394006746 Walker B motif; other site 1142394006747 arginine finger; other site 1142394006748 GxxExxY protein; Region: GxxExxY; TIGR04256 1142394006749 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1142394006750 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1142394006751 Protein of unknown function DUF58; Region: DUF58; pfam01882 1142394006752 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1142394006753 Homeodomain-like domain; Region: HTH_23; cl17451 1142394006754 Winged helix-turn helix; Region: HTH_29; pfam13551 1142394006755 Homeodomain-like domain; Region: HTH_32; pfam13565 1142394006756 Cellobiose phosphorylase [Carbohydrate transport and metabolism]; Region: COG3459 1142394006757 peptide chain release factor 2; Validated; Region: prfB; PRK00578 1142394006758 PCRF domain; Region: PCRF; pfam03462 1142394006759 RF-1 domain; Region: RF-1; pfam00472 1142394006760 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1142394006761 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 1142394006762 active site 1142394006763 catalytic triad [active] 1142394006764 oxyanion hole [active] 1142394006765 PA14 domain; Region: PA14; cl08459 1142394006766 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1142394006767 active site 1142394006768 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1142394006769 SecY translocase; Region: SecY; pfam00344 1142394006770 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1142394006771 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1142394006772 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1142394006773 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1142394006774 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1142394006775 5S rRNA interface [nucleotide binding]; other site 1142394006776 23S rRNA interface [nucleotide binding]; other site 1142394006777 L5 interface [polypeptide binding]; other site 1142394006778 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1142394006779 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1142394006780 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1142394006781 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1142394006782 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1142394006783 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1142394006784 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1142394006785 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1142394006786 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1142394006787 RNA binding site [nucleotide binding]; other site 1142394006788 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1142394006789 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1142394006790 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1142394006791 putative translocon interaction site; other site 1142394006792 23S rRNA interface [nucleotide binding]; other site 1142394006793 signal recognition particle (SRP54) interaction site; other site 1142394006794 L23 interface [polypeptide binding]; other site 1142394006795 trigger factor interaction site; other site 1142394006796 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1142394006797 23S rRNA interface [nucleotide binding]; other site 1142394006798 5S rRNA interface [nucleotide binding]; other site 1142394006799 putative antibiotic binding site [chemical binding]; other site 1142394006800 L25 interface [polypeptide binding]; other site 1142394006801 L27 interface [polypeptide binding]; other site 1142394006802 ribosomal protein S3, bacterial type; Region: rpsC_bact; TIGR01009 1142394006803 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1142394006804 G-X-X-G motif; other site 1142394006805 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1142394006806 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1142394006807 protein-rRNA interface [nucleotide binding]; other site 1142394006808 putative translocon binding site; other site 1142394006809 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1142394006810 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1142394006811 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1142394006812 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1142394006813 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1142394006814 Ribosomal protein L4/L1 family; Region: Ribosomal_L4; cl00325 1142394006815 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 1142394006816 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1142394006817 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1142394006818 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1142394006819 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1142394006820 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1142394006821 Methionyl-tRNA formyltransferase [Translation, ribosomal structure and biogenesis]; Region: Fmt; COG0223 1142394006822 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1142394006823 putative active site [active] 1142394006824 substrate binding site [chemical binding]; other site 1142394006825 putative cosubstrate binding site; other site 1142394006826 catalytic site [active] 1142394006827 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1142394006828 substrate binding site [chemical binding]; other site 1142394006829 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1142394006830 active site 1142394006831 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 1142394006832 tartrate dehydrogenase; Region: TTC; TIGR02089 1142394006833 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 1142394006834 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1142394006835 catalytic residues [active] 1142394006836 short chain dehydrogenase; Validated; Region: PRK08324 1142394006837 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; smart01007 1142394006838 classical (c) SDRs; Region: SDR_c; cd05233 1142394006839 NAD(P) binding site [chemical binding]; other site 1142394006840 active site 1142394006841 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1142394006842 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1142394006843 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1142394006844 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 1142394006845 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1142394006846 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 1142394006847 active site 1142394006848 intersubunit interface [polypeptide binding]; other site 1142394006849 zinc binding site [ion binding]; other site 1142394006850 Na+ binding site [ion binding]; other site 1142394006851 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 1142394006852 heterotetramer interface [polypeptide binding]; other site 1142394006853 active site pocket [active] 1142394006854 cleavage site 1142394006855 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 1142394006856 Cu(I) binding site [ion binding]; other site 1142394006857 cytochrome c oxidase, subunit II; Region: CoxB; TIGR02866 1142394006858 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1142394006859 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 1142394006860 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 1142394006861 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 1142394006862 Subunit I/III interface [polypeptide binding]; other site 1142394006863 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 1142394006864 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626 1142394006865 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cl00211 1142394006866 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 1142394006867 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 1142394006868 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 1142394006869 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1142394006870 Walker A/P-loop; other site 1142394006871 ATP binding site [chemical binding]; other site 1142394006872 Q-loop/lid; other site 1142394006873 ABC transporter signature motif; other site 1142394006874 Walker B; other site 1142394006875 D-loop; other site 1142394006876 H-loop/switch region; other site 1142394006877 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1142394006878 FtsX-like permease family; Region: FtsX; pfam02687 1142394006879 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1142394006880 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1142394006881 potassium/proton antiporter; Reviewed; Region: PRK05326 1142394006882 TrkA-C domain; Region: TrkA_C; pfam02080 1142394006883 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 1142394006884 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1142394006885 active site 1142394006886 NTP binding site [chemical binding]; other site 1142394006887 metal binding triad [ion binding]; metal-binding site 1142394006888 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 1142394006889 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1142394006890 catalytic residue [active] 1142394006891 response regulator FixJ; Provisional; Region: fixJ; PRK09390 1142394006892 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1142394006893 active site 1142394006894 phosphorylation site [posttranslational modification] 1142394006895 intermolecular recognition site; other site 1142394006896 dimerization interface [polypeptide binding]; other site 1142394006897 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1142394006898 DNA binding residues [nucleotide binding] 1142394006899 dimerization interface [polypeptide binding]; other site 1142394006900 PAS domain S-box; Region: sensory_box; TIGR00229 1142394006901 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1142394006902 putative active site [active] 1142394006903 heme pocket [chemical binding]; other site 1142394006904 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1142394006905 dimer interface [polypeptide binding]; other site 1142394006906 phosphorylation site [posttranslational modification] 1142394006907 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1142394006908 ATP binding site [chemical binding]; other site 1142394006909 Mg2+ binding site [ion binding]; other site 1142394006910 G-X-G motif; other site 1142394006911 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 1142394006912 Putative SAM-dependent methyltransferase; Region: SAM_MT; cl17517 1142394006913 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 1142394006914 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1142394006915 active site residue [active] 1142394006916 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1142394006917 active site residue [active] 1142394006918 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 1142394006919 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1142394006920 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1142394006921 putative active site [active] 1142394006922 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 1142394006923 ThiC family; Region: ThiC; pfam01964 1142394006924 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1142394006925 putative active site [active] 1142394006926 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1142394006927 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1142394006928 active site 1142394006929 catalytic tetrad [active] 1142394006930 EVE domain; Region: EVE; pfam01878 1142394006931 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1142394006932 active site 1142394006933 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1142394006934 NAD(P) binding site [chemical binding]; other site 1142394006935 active site 1142394006936 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1142394006937 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1142394006938 motif 1; other site 1142394006939 dimer interface [polypeptide binding]; other site 1142394006940 active site 1142394006941 motif 2; other site 1142394006942 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1142394006943 putative deacylase active site [active] 1142394006944 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1142394006945 active site 1142394006946 motif 3; other site 1142394006947 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1142394006948 anticodon binding site; other site 1142394006949 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1142394006950 substrate binding site [chemical binding]; other site 1142394006951 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 1142394006952 Catalytic domain of Protein Kinases; Region: PKc; cd00180 1142394006953 active site 1142394006954 ATP binding site [chemical binding]; other site 1142394006955 substrate binding site [chemical binding]; other site 1142394006956 activation loop (A-loop); other site 1142394006957 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1142394006958 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1142394006959 active site 1142394006960 catalytic tetrad [active] 1142394006961 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 1142394006962 Histone deacetylase class IV also known as histone deacetylase 11; Region: HDAC_classIV; cd09993 1142394006963 putative active site [active] 1142394006964 Zn binding site [ion binding]; other site 1142394006965 Cysteine desulfurase SufE subunit [Posttranslational modification, protein turnover, chaperones]; Region: sufE; COG2166 1142394006966 Glycosyltransferase 4 (GT4) includes both eukaryotic and prokaryotic UDP-D-N-acetylhexosamine:polyprenol phosphate D-N-acetylhexosamine-1-phosphate transferases. They catalyze the transfer of a D-N-acetylhexosamine 1-phosphate to a membrane-bound...; Region: GT_MraY-like; cl10571 1142394006967 Mg++ binding site [ion binding]; other site 1142394006968 putative catalytic motif [active] 1142394006969 Protein of unknown function (DUF2945); Region: DUF2945; pfam11160 1142394006970 NeuB family; Region: NeuB; pfam03102 1142394006971 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 1142394006972 putative substrate binding site [chemical binding]; other site 1142394006973 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 1142394006974 L-arabinose isomerase; Provisional; Region: PRK02929 1142394006975 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1142394006976 trimer interface [polypeptide binding]; other site 1142394006977 substrate binding site [chemical binding]; other site 1142394006978 Mn binding site [ion binding]; other site 1142394006979 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1142394006980 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1142394006981 intersubunit interface [polypeptide binding]; other site 1142394006982 active site 1142394006983 Zn2+ binding site [ion binding]; other site 1142394006984 O-Glycosyl hydrolase [Cell envelope biogenesis, outer membrane]; Region: COG5520 1142394006985 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1142394006986 GIY-YIG motif/motif A; other site 1142394006987 active site 1142394006988 catalytic site [active] 1142394006989 putative DNA binding site [nucleotide binding]; other site 1142394006990 metal binding site [ion binding]; metal-binding site 1142394006991 UvrB/uvrC motif; Region: UVR; pfam02151 1142394006992 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1142394006993 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 1142394006994 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1142394006995 putative ligand binding site [chemical binding]; other site 1142394006996 putative NAD binding site [chemical binding]; other site 1142394006997 catalytic site [active] 1142394006998 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 1142394006999 von Willebrand factor type A domain; Region: VWA_2; pfam13519 1142394007000 metal ion-dependent adhesion site (MIDAS); other site 1142394007001 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1142394007002 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1142394007003 putative acyl-acceptor binding pocket; other site 1142394007004 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1142394007005 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1142394007006 S-adenosylmethionine binding site [chemical binding]; other site 1142394007007 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 1142394007008 polyphosphate kinase; Provisional; Region: PRK05443 1142394007009 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1142394007010 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1142394007011 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 1142394007012 putative domain interface [polypeptide binding]; other site 1142394007013 putative active site [active] 1142394007014 catalytic site [active] 1142394007015 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 1142394007016 putative domain interface [polypeptide binding]; other site 1142394007017 putative active site [active] 1142394007018 catalytic site [active] 1142394007019 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1142394007020 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1142394007021 P-loop; other site 1142394007022 Magnesium ion binding site [ion binding]; other site 1142394007023 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1142394007024 Magnesium ion binding site [ion binding]; other site 1142394007025 N-terminal Early set domain, a glycogen binding domain, associated with the catalytic domain of AMP-activated protein kinase beta subunit; Region: E_set_AMPKbeta_like_N; cd02859 1142394007026 glycogen binding site [chemical binding]; other site 1142394007027 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; cl03652 1142394007028 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1142394007029 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1142394007030 G1 box; other site 1142394007031 GTP/Mg2+ binding site [chemical binding]; other site 1142394007032 G2 box; other site 1142394007033 Switch I region; other site 1142394007034 G3 box; other site 1142394007035 Switch II region; other site 1142394007036 G4 box; other site 1142394007037 G5 box; other site 1142394007038 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1142394007039 Elongation factor G C-terminus. This domain includes the carboxyl terminal regions of elongation factors (EFs) bacterial EF-G, eukaryotic and archeal EF-2 and eukaryotic mitochondrial mtEFG1s and mtEFG2s. This group also includes proteins similar to the...; Region: Elongation_Factor_C; cl02785 1142394007040 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 1142394007041 Response regulator receiver domain; Region: Response_reg; pfam00072 1142394007042 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1142394007043 active site 1142394007044 phosphorylation site [posttranslational modification] 1142394007045 intermolecular recognition site; other site 1142394007046 dimerization interface [polypeptide binding]; other site 1142394007047 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1142394007048 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 1142394007049 beta-phosphoglucomutase family hydrolase; Region: PGMB-YQAB-SF; TIGR02009 1142394007050 ribulokinase; Provisional; Region: PRK04123 1142394007051 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1142394007052 nucleotide binding site [chemical binding]; other site 1142394007053 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 1142394007054 Transposase domain (DUF772); Region: DUF772; pfam05598 1142394007055 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1142394007056 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1142394007057 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1142394007058 ergothioneine biosynthesis protein EgtB; Region: egtB_TIGR03440 1142394007059 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 1142394007060 uncharacterized subgroup of the Na(+)/iodide (NIS) cotransporter subfamily; putative solute-binding domain; Region: SLC5sbd_NIS-like_u3; cd11495 1142394007061 putative transporter; Provisional; Region: PRK10484 1142394007062 Na binding site [ion binding]; other site 1142394007063 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1142394007064 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1142394007065 DNA binding site [nucleotide binding] 1142394007066 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1142394007067 ligand binding site [chemical binding]; other site 1142394007068 dimerization interface [polypeptide binding]; other site 1142394007069 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1142394007070 DDE superfamily endonuclease; Region: DDE_3; pfam13358 1142394007071 Homeodomain-like domain; Region: HTH_23; cl17451 1142394007072 Winged helix-turn helix; Region: HTH_29; pfam13551 1142394007073 Homeodomain-like domain; Region: HTH_32; pfam13565 1142394007074 dimethylhistidine N-methyltransferase; Region: egtD_ergothio; TIGR03438 1142394007075 Uncharacterized conserved protein (DUF2260); Region: DUF2260; pfam10017 1142394007076 Predicted deacylase [General function prediction only]; Region: COG3608 1142394007077 Peptidase M14 Succinylglutamate desuccinylase (ASTE)/aspartoacylase (ASPA)-like; uncharacterized subgroup; Region: M14_ASTE_ASPA_like_1; cd06251 1142394007078 putative active site [active] 1142394007079 Zn binding site [ion binding]; other site 1142394007080 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 1142394007081 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1142394007082 motif II; other site 1142394007083 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1142394007084 PAS fold; Region: PAS_3; pfam08447 1142394007085 putative active site [active] 1142394007086 heme pocket [chemical binding]; other site 1142394007087 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 1142394007088 active site 1142394007089 putative DNA-binding cleft [nucleotide binding]; other site 1142394007090 dimer interface [polypeptide binding]; other site 1142394007091 Bacterial sugar transferase; Region: Bac_transf; pfam02397 1142394007092 This family is most closely related to the GT1 family of glycosyltransferases. wbaZ in Salmonella enterica has been shown to possess the mannosyl transferase activity. The members of this family are found in certain bacteria and Archaea; Region: GT1_wbaZ_like; cd03804 1142394007093 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1142394007094 putative ADP-binding pocket [chemical binding]; other site 1142394007095 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1142394007096 aspartate kinase; Reviewed; Region: PRK09034 1142394007097 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1142394007098 nucleotide binding site [chemical binding]; other site 1142394007099 substrate binding site [chemical binding]; other site 1142394007100 ACT domains located C-terminal to the catalytic domain of the lysine plus threonine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-YclM-BS_1; cd04911 1142394007101 allosteric regulatory residue; other site 1142394007102 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1142394007103 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1142394007104 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 1142394007105 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1142394007106 catalytic residue [active] 1142394007107 Protein of unknown function, DUF608; Region: DUF608; pfam04685 1142394007108 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 1142394007109 chaperone protein DnaJ; Provisional; Region: PRK14299 1142394007110 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1142394007111 HSP70 interaction site [polypeptide binding]; other site 1142394007112 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1142394007113 substrate binding site [polypeptide binding]; other site 1142394007114 dimer interface [polypeptide binding]; other site 1142394007115 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 1142394007116 Clp amino terminal domain; Region: Clp_N; pfam02861 1142394007117 Clp amino terminal domain; Region: Clp_N; pfam02861 1142394007118 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1142394007119 Walker A motif; other site 1142394007120 ATP binding site [chemical binding]; other site 1142394007121 Walker B motif; other site 1142394007122 arginine finger; other site 1142394007123 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1142394007124 Walker A motif; other site 1142394007125 ATP binding site [chemical binding]; other site 1142394007126 Walker B motif; other site 1142394007127 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1142394007128 Curli production assembly/transport component CsgG; Region: CsgG; cl17434 1142394007129 flagellin; Provisional; Region: PRK12806 1142394007130 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1142394007131 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1142394007132 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 1142394007133 DEAD-like helicases superfamily; Region: DEXDc; smart00487 1142394007134 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1142394007135 ATP binding site [chemical binding]; other site 1142394007136 putative Mg++ binding site [ion binding]; other site 1142394007137 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1142394007138 nucleotide binding region [chemical binding]; other site 1142394007139 ATP-binding site [chemical binding]; other site 1142394007140 TRCF domain; Region: TRCF; cl04088 1142394007141 nicotinate phosphoribosyltransferase; Validated; Region: PRK09243 1142394007142 Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction...; Region: NAPRTase_A; cd01570 1142394007143 active site 1142394007144 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1142394007145 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cl00220 1142394007146 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 1142394007147 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1142394007148 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1142394007149 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1142394007150 alpha subunit interaction interface [polypeptide binding]; other site 1142394007151 Walker A motif; other site 1142394007152 ATP binding site [chemical binding]; other site 1142394007153 Walker B motif; other site 1142394007154 inhibitor binding site; inhibition site 1142394007155 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1142394007156 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 1142394007157 active site 1142394007158 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1142394007159 Glycosyl hydrolase family 20, catalytic domain; Region: Glyco_hydro_20; pfam00728 1142394007160 Glycosyl hydrolase family 20 (GH20) catalytic domain of N-acetyl-beta-D-glucosaminidase (GcnA, also known as BhsA) and related proteins. GcnA is an exoglucosidase which cleaves N-acetyl-beta-D-galactosamine (NAG) and N-acetyl-beta-D-galactosamine...; Region: GH20_GcnA-like; cd06565 1142394007161 putative active site [active] 1142394007162 Adenine deaminase [Nucleotide transport and metabolism]; Region: AdeC; COG1001 1142394007163 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1142394007164 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1142394007165 active site 1142394007166 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1142394007167 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1142394007168 active site 1142394007169 homotetramer interface [polypeptide binding]; other site 1142394007170 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 1142394007171 putative OHCU decarboxylase; Provisional; Region: PRK13798 1142394007172 allantoinase; Region: allantoinase; TIGR03178 1142394007173 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1142394007174 active site 1142394007175 urate oxidase; Region: urate_oxi; TIGR03383 1142394007176 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 1142394007177 active site 1142394007178 Domain of unknown function (DUF820). This family consists of hypothetical proteins that are greatly expanded in cyanobacteria. The proteins are found sporadically in other bacteria. They have been predicted to belong to the PD-(D/E)xK superfamily of...; Region: DUF820; cd06260 1142394007179 putative active site [active] 1142394007180 Transposase domain (DUF772); Region: DUF772; pfam05598 1142394007181 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1142394007182 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1142394007183 allantoate amidohydrolase; Reviewed; Region: PRK09290 1142394007184 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1142394007185 active site 1142394007186 metal binding site [ion binding]; metal-binding site 1142394007187 dimer interface [polypeptide binding]; other site 1142394007188 hypothetical protein; Provisional; Region: PRK11171 1142394007189 Cupin domain; Region: Cupin_2; cl17218 1142394007190 allantoate amidohydrolase; Reviewed; Region: PRK09290 1142394007191 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1142394007192 active site 1142394007193 metal binding site [ion binding]; metal-binding site 1142394007194 dimer interface [polypeptide binding]; other site 1142394007195 xanthine dehydrogenase, small subunit; Region: xanthine_xdhA; TIGR02963 1142394007196 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1142394007197 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1142394007198 xanthine dehydrogenase, molybdopterin binding subunit; Region: xanthine_xdhB; TIGR02965 1142394007199 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 1142394007200 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1142394007201 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1142394007202 xanthine dehydrogenase accessory protein XdhC; Region: xanthine_xdhC; TIGR02964 1142394007203 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1142394007204 Serine-pyruvate aminotransferase/archaeal aspartate aminotransferase [Amino acid transport and metabolism]; Region: COG0075 1142394007205 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1142394007206 catalytic residue [active] 1142394007207 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 1142394007208 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1142394007209 HlyD family secretion protein; Region: HlyD_3; pfam13437 1142394007210 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 1142394007211 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1142394007212 putative active site [active] 1142394007213 catalytic site [active] 1142394007214 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1142394007215 PLD-like domain; Region: PLDc_2; pfam13091 1142394007216 putative active site [active] 1142394007217 catalytic site [active] 1142394007218 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1142394007219 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 1142394007220 signal recognition particle protein; Provisional; Region: PRK10867 1142394007221 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1142394007222 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1142394007223 P loop; other site 1142394007224 GTP binding site [chemical binding]; other site 1142394007225 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1142394007226 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1142394007227 dimerization domain swap beta strand [polypeptide binding]; other site 1142394007228 regulatory protein interface [polypeptide binding]; other site 1142394007229 active site 1142394007230 regulatory phosphorylation site [posttranslational modification]; other site 1142394007231 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1142394007232 AAA domain; Region: AAA_23; pfam13476 1142394007233 Walker A/P-loop; other site 1142394007234 ATP binding site [chemical binding]; other site 1142394007235 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 1142394007236 ABC transporter signature motif; other site 1142394007237 Walker B; other site 1142394007238 D-loop; other site 1142394007239 H-loop/switch region; other site 1142394007240 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1142394007241 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1142394007242 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1142394007243 Acylphosphatase; Region: Acylphosphatase; pfam00708 1142394007244 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 1142394007245 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 1142394007246 active site 1142394007247 Domain of unknown function DUF59; Region: DUF59; cl00941 1142394007248 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1142394007249 active site 1142394007250 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 1142394007251 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1142394007252 putative acyl-acceptor binding pocket; other site 1142394007253 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 1142394007254 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 1142394007255 active site 2 [active] 1142394007256 active site 1 [active] 1142394007257 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 1142394007258 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1142394007259 Putative Catalytic site; other site 1142394007260 DXD motif; other site 1142394007261 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cl10015 1142394007262 homotrimer interaction site [polypeptide binding]; other site 1142394007263 putative active site [active] 1142394007264 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1142394007265 Helix-turn-helix diphteria tox regulatory element; Region: HTH_DTXR; smart00529 1142394007266 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1142394007267 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 1142394007268 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 1142394007269 metal binding site [ion binding]; metal-binding site 1142394007270 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 1142394007271 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1142394007272 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1142394007273 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1142394007274 ABC-ATPase subunit interface; other site 1142394007275 dimer interface [polypeptide binding]; other site 1142394007276 putative PBP binding regions; other site 1142394007277 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1142394007278 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1142394007279 ABC-ATPase subunit interface; other site 1142394007280 dimer interface [polypeptide binding]; other site 1142394007281 putative PBP binding regions; other site 1142394007282 Predicted permease; Region: DUF318; cl17795 1142394007283 Predicted permease; Region: DUF318; cl17795 1142394007284 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 1142394007285 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1142394007286 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 1142394007287 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1142394007288 G1 box; other site 1142394007289 GTP/Mg2+ binding site [chemical binding]; other site 1142394007290 Switch I region; other site 1142394007291 G2 box; other site 1142394007292 G3 box; other site 1142394007293 Switch II region; other site 1142394007294 G4 box; other site 1142394007295 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 1142394007296 Nucleoside recognition; Region: Gate; pfam07670 1142394007297 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1142394007298 Nucleoside recognition; Region: Gate; pfam07670 1142394007299 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1142394007300 active site 1142394007301 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1142394007302 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1142394007303 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 1142394007304 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 1142394007305 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 1142394007306 Protein of unknown function DUF58; Region: DUF58; pfam01882 1142394007307 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 1142394007308 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1142394007309 lipoyl attachment site [posttranslational modification]; other site 1142394007310 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1142394007311 Formamidopyrimidine-DNA glycosylase [DNA replication, recombination, and repair]; Region: Nei; COG0266 1142394007312 N-terminal domain of the actinomycetal Nei1 and related DNA glycosylases; Region: AcNei1_N; cd08970 1142394007313 putative DNA binding site [nucleotide binding]; other site 1142394007314 catalytic residue [active] 1142394007315 putative H2TH interface [polypeptide binding]; other site 1142394007316 putative catalytic residues [active] 1142394007317 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1142394007318 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1142394007319 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1142394007320 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1142394007321 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1142394007322 catalytic residue [active] 1142394007323 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 1142394007324 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1142394007325 motif II; other site 1142394007326 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1142394007327 G1 box; other site 1142394007328 GTP/Mg2+ binding site [chemical binding]; other site 1142394007329 G2 box; other site 1142394007330 Switch I region; other site 1142394007331 G3 box; other site 1142394007332 Switch II region; other site 1142394007333 Domain of unknown function (DUF3482); Region: DUF3482; pfam11981 1142394007334 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 1142394007335 Protein of unknown function (DUF2868); Region: DUF2868; pfam11067 1142394007336 SprT-like family; Region: SprT-like; pfam10263 1142394007337 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1142394007338 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1142394007339 active site 1142394007340 catalytic tetrad [active] 1142394007341 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1142394007342 DNA methylase; Region: N6_N4_Mtase; cl17433 1142394007343 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 1142394007344 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 1142394007345 DNA binding site [nucleotide binding] 1142394007346 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 1142394007347 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1142394007348 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1142394007349 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1142394007350 SNF2 Helicase protein; Region: DUF3670; pfam12419 1142394007351 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 1142394007352 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1142394007353 ATP binding site [chemical binding]; other site 1142394007354 putative Mg++ binding site [ion binding]; other site 1142394007355 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1142394007356 nucleotide binding region [chemical binding]; other site 1142394007357 ATP-binding site [chemical binding]; other site 1142394007358 Uncharacterized conserved protein [Function unknown]; Region: COG4279 1142394007359 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1142394007360 Protein of unknown function DUF262; Region: DUF262; pfam03235 1142394007361 Uncharacterized conserved protein [Function unknown]; Region: COG3472 1142394007362 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 1142394007363 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1142394007364 ATP binding site [chemical binding]; other site 1142394007365 putative Mg++ binding site [ion binding]; other site 1142394007366 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1142394007367 nucleotide binding region [chemical binding]; other site 1142394007368 ATP-binding site [chemical binding]; other site 1142394007369 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1142394007370 DNA methylase; Region: N6_N4_Mtase; pfam01555 1142394007371 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 1142394007372 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1142394007373 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 1142394007374 Complex I intermediate-associated protein 30 (CIA30); Region: CIA30; pfam08547 1142394007375 Carbohydrate Binding Module family 35 (CBM35), pectate lyase-like; appended mainly to enzymes that bind mannan (Man), xylan, glucuronic acid (GlcA) and possibly glucans; Region: CBM35_pectate_lyase-like; cd04082 1142394007376 Ca binding site [ion binding]; other site 1142394007377 Ca binding site (active) [ion binding]; other site 1142394007378 ligand binding site [chemical binding]; other site 1142394007379 Carbohydrate Binding Module 6 (CBM6) and CBM35_like superfamily; Region: CBM6-CBM35-CBM36_like; cl14880 1142394007380 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 1142394007381 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 1142394007382 NAD binding site [chemical binding]; other site 1142394007383 HDOD domain; Region: HDOD; pfam08668 1142394007384 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1142394007385 Zn2+ binding site [ion binding]; other site 1142394007386 Mg2+ binding site [ion binding]; other site 1142394007387 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 1142394007388 DHH family; Region: DHH; pfam01368 1142394007389 DHHA1 domain; Region: DHHA1; pfam02272 1142394007390 isocitrate dehydrogenase; Validated; Region: PRK09222 1142394007391 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1142394007392 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1142394007393 dimerization interface [polypeptide binding]; other site 1142394007394 putative Zn2+ binding site [ion binding]; other site 1142394007395 putative DNA binding site [nucleotide binding]; other site 1142394007396 Stage II sporulation protein; Region: SpoIID; pfam08486 1142394007397 SpoIID/LytB domain; Region: SpoIID_LytB; TIGR02669 1142394007398 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 1142394007399 putative active cleft [active] 1142394007400 dimerization interface [polypeptide binding]; other site 1142394007401 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1142394007402 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1142394007403 DNA binding site [nucleotide binding] 1142394007404 domain linker motif; other site 1142394007405 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 1142394007406 ligand binding site [chemical binding]; other site 1142394007407 Sugar-binding cellulase-like; Region: Cellulase-like; pfam12876 1142394007408 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1142394007409 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1142394007410 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1142394007411 putative bacillithiol system oxidoreductase, YpdA family; Region: Bthiol_YpdA; TIGR04018 1142394007412 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 1142394007413 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1142394007414 Transposase domain (DUF772); Region: DUF772; pfam05598 1142394007415 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1142394007416 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 1142394007417 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1142394007418 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1142394007419 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1142394007420 E3 interaction surface; other site 1142394007421 lipoyl attachment site [posttranslational modification]; other site 1142394007422 e3 binding domain; Region: E3_binding; pfam02817 1142394007423 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1142394007424 This domain is found in the extracellular portion of receptor-like proteins - such as serine/threonine kinases and adenylyl cyclases; Region: CHASE; smart01079 1142394007425 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1142394007426 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1142394007427 metal binding site [ion binding]; metal-binding site 1142394007428 active site 1142394007429 I-site; other site 1142394007430 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1142394007431 hypothetical protein; Validated; Region: PRK00029 1142394007432 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 1142394007433 PilZ domain; Region: PilZ; cl01260 1142394007434 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1142394007435 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1142394007436 active site 1142394007437 6-phosphofructokinase; Provisional; Region: PRK14072 1142394007438 active site 1142394007439 ADP/pyrophosphate binding site [chemical binding]; other site 1142394007440 dimerization interface [polypeptide binding]; other site 1142394007441 allosteric effector site; other site 1142394007442 fructose-1,6-bisphosphate binding site; other site 1142394007443 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1142394007444 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1142394007445 active site 1142394007446 phosphate binding residues; other site 1142394007447 catalytic residues [active] 1142394007448 Possible lysine decarboxylase; Region: Lysine_decarbox; pfam03641 1142394007449 glycosyl hydrolase family 16; Region: Glyco_hydrolase_16; cl00218 1142394007450 active site 1142394007451 catalytic residues [active] 1142394007452 Cupin domain; Region: Cupin_2; cl17218 1142394007453 Helix-turn-helix domain; Region: HTH_18; pfam12833 1142394007454 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1142394007455 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 1142394007456 beta-D-glucuronidase; Provisional; Region: PRK10150 1142394007457 spore photoproduct lyase; Region: photo_TT_lyase; cl15393 1142394007458 DNA repair photolyase [DNA replication, recombination, and repair]; Region: SplB; COG1533 1142394007459 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1142394007460 oligomeric interface; other site 1142394007461 putative active site [active] 1142394007462 homodimer interface [polypeptide binding]; other site 1142394007463 Transposase, Mutator family; Region: Transposase_mut; pfam00872 1142394007464 MULE transposase domain; Region: MULE; pfam10551 1142394007465 Transposase IS200 like; Region: Y1_Tnp; cl00848 1142394007466 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1142394007467 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1142394007468 ring oligomerisation interface [polypeptide binding]; other site 1142394007469 ATP/Mg binding site [chemical binding]; other site 1142394007470 stacking interactions; other site 1142394007471 hinge regions; other site 1142394007472 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1142394007473 oligomerisation interface [polypeptide binding]; other site 1142394007474 mobile loop; other site 1142394007475 roof hairpin; other site 1142394007476 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 1142394007477 active site 1142394007478 phosphorylation site [posttranslational modification] 1142394007479 intermolecular recognition site; other site 1142394007480 dimerization interface [polypeptide binding]; other site 1142394007481 hypothetical protein; Provisional; Region: PRK09256 1142394007482 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 1142394007483 nudix motif; other site 1142394007484 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1142394007485 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1142394007486 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1142394007487 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1142394007488 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1142394007489 DNA binding site [nucleotide binding] 1142394007490 catalytic residue [active] 1142394007491 H2TH interface [polypeptide binding]; other site 1142394007492 putative catalytic residues [active] 1142394007493 turnover-facilitating residue; other site 1142394007494 intercalation triad [nucleotide binding]; other site 1142394007495 8OG recognition residue [nucleotide binding]; other site 1142394007496 putative reading head residues; other site 1142394007497 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1142394007498 Domain of unknown function DUF21; Region: DUF21; pfam01595 1142394007499 FOG: CBS domain [General function prediction only]; Region: COG0517 1142394007500 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1142394007501 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1142394007502 putative trimer interface [polypeptide binding]; other site 1142394007503 putative CoA binding site [chemical binding]; other site 1142394007504 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1142394007505 Protein of unknwon function (DUF2893); Region: DUF2893; pfam11459 1142394007506 SprT-like family; Region: SprT-like; pfam10263 1142394007507 hypothetical protein; Reviewed; Region: PRK00024 1142394007508 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1142394007509 MPN+ (JAMM) motif; other site 1142394007510 Zinc-binding site [ion binding]; other site 1142394007511 Antirestriction protein [DNA replication, recombination, and repair]; Region: COG4227 1142394007512 Domain of unknown function (DUF1738); Region: DUF1738; pfam08401 1142394007513 Glycosyl hydrolase family 47; Region: Glyco_hydro_47; cl08327 1142394007514 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 1142394007515 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 1142394007516 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 1142394007517 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1142394007518 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1142394007519 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1142394007520 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 1142394007521 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1142394007522 HlyD family secretion protein; Region: HlyD_3; pfam13437 1142394007523 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 1142394007524 Protein of unknown function (DUF3347); Region: DUF3347; pfam11827 1142394007525 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 1142394007526 iron-sulfur cluster [ion binding]; other site 1142394007527 [2Fe-2S] cluster binding site [ion binding]; other site 1142394007528 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1142394007529 Transcriptional regulators CsoR (copper-sensitive operon repressor), RcnR, and FrmR, and related domains; this domain superfamily was previously known as DUF156; Region: CsoR-like_DUF156; cd10148 1142394007530 putative homodimer interface [polypeptide binding]; other site 1142394007531 putative homotetramer interface [polypeptide binding]; other site 1142394007532 putative allosteric switch controlling residues; other site 1142394007533 putative metal binding site [ion binding]; other site 1142394007534 putative homodimer-homodimer interface [polypeptide binding]; other site 1142394007535 Cysteine-rich 4 helical bundle widely conserved in bacteria; Region: DUF326; cd08026 1142394007536 dimerization interface [polypeptide binding]; other site 1142394007537 Outer membrane efflux protein; Region: OEP; pfam02321 1142394007538 Outer membrane efflux protein; Region: OEP; pfam02321 1142394007539 Putative multicopper oxidases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: SufI; COG2132 1142394007540 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1142394007541 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1142394007542 YHS domain; Region: YHS; pfam04945 1142394007543 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 1142394007544 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1142394007545 Soluble P-type ATPase [General function prediction only]; Region: COG4087 1142394007546 Outer membrane efflux protein; Region: OEP; pfam02321 1142394007547 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 1142394007548 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1142394007549 HlyD family secretion protein; Region: HlyD_3; pfam13437 1142394007550 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 1142394007551 TcdA/TcdB pore forming domain; Region: TcdA_TcdB_pore; pfam12920 1142394007552 Cation efflux family; Region: Cation_efflux; cl00316 1142394007553 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 1142394007554 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1142394007555 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1142394007556 Uncharacterized protein conserved in bacteria (DUF2219); Region: DUF2219; pfam09982 1142394007557 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 1142394007558 Domain of unknown function (DUF4095); Region: DUF4095; pfam13338 1142394007559 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1142394007560 active site 1142394007561 DNA binding site [nucleotide binding] 1142394007562 Int/Topo IB signature motif; other site 1142394007563 Protein of unknown function (DUF2274); Region: DUF2274; cl02406 1142394007564 Bacterial conjugation TrbI-like protein; Region: TrbI; cl04242 1142394007565 VirB9/CagX/TrbG, a component of the type IV secretion system; Region: VirB9_CagX_TrbG; cd06911 1142394007566 VirB7 interaction site; other site 1142394007567 VirB8 protein; Region: VirB8; cl01500 1142394007568 TrbL/VirB6 plasmid conjugal transfer protein; Region: TrbL; pfam04610 1142394007569 Conjugal transfer/entry exclusion protein [Intracellular trafficking and secretion]; Region: COG5314 1142394007570 conjugal transfer ATPase TrbE; Provisional; Region: PRK13873 1142394007571 Domain of unknown function DUF87; Region: DUF87; pfam01935 1142394007572 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 1142394007573 Type IV secretory pathway, VirB3-like protein; Region: VirB3; cl01501 1142394007574 P-type conjugative transfer ATPase TrbB; Region: TrbB_P; TIGR02782 1142394007575 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1142394007576 Walker A motif; other site 1142394007577 ATP binding site [chemical binding]; other site 1142394007578 Walker B motif; other site 1142394007579 Type IV secretory system Conjugative DNA transfer; Region: T4SS-DNA_transf; pfam02534 1142394007580 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 1142394007581 Walker A motif; other site 1142394007582 ATP binding site [chemical binding]; other site 1142394007583 Walker B motif; other site 1142394007584 Type IV secretory pathway, VirD2 components (relaxase) [Intracellular trafficking and secretion]; Region: VirD2; COG3843 1142394007585 Type IV secretory pathway, protease TraF [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: TraF; COG4959 1142394007586 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 1142394007587 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1142394007588 P-loop; other site 1142394007589 Magnesium ion binding site [ion binding]; other site 1142394007590 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 1142394007591 Magnesium ion binding site [ion binding]; other site