-- dump date 20140619_234206 -- class Genbank::misc_feature -- table misc_feature_note -- id note 530564000001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564000002 Walker A motif; other site 530564000003 ATP binding site [chemical binding]; other site 530564000004 Walker B motif; other site 530564000005 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 530564000006 DnaA box-binding interface [nucleotide binding]; other site 530564000007 PQQ-like domain; Region: PQQ_2; pfam13360 530564000008 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 530564000009 Trp docking motif [polypeptide binding]; other site 530564000010 active site 530564000011 PQQ-like domain; Region: PQQ_2; pfam13360 530564000012 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564000013 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 530564000014 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 530564000015 Manganese catalase, ferritin-like diiron-binding domain; Region: Mn_catalase; cd01051 530564000016 dimanganese center [ion binding]; other site 530564000017 BON domain; Region: BON; pfam04972 530564000018 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 530564000019 active site 530564000020 catalytic motif [active] 530564000021 Zn binding site [ion binding]; other site 530564000022 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 530564000023 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 530564000024 Nucleoside recognition; Region: Gate; pfam07670 530564000025 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 530564000026 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 530564000027 active site 530564000028 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 530564000029 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 530564000030 PEGA domain; Region: PEGA; pfam08308 530564000031 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 530564000032 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 530564000033 anti sigma factor interaction site; other site 530564000034 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 530564000035 dimer interface [polypeptide binding]; other site 530564000036 catalytic triad [active] 530564000037 peroxidatic and resolving cysteines [active] 530564000038 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 530564000039 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 530564000040 Competence protein; Region: Competence; pfam03772 530564000041 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 530564000042 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 530564000043 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 530564000044 active site 530564000045 HIGH motif; other site 530564000046 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 530564000047 active site 530564000048 KMSKS motif; other site 530564000049 BON domain; Region: BON; pfam04972 530564000050 Peptidase family M48; Region: Peptidase_M48; cl12018 530564000051 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 530564000052 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 530564000053 NAD(P) binding site [chemical binding]; other site 530564000054 active site 530564000055 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 530564000056 Phosphotransferase enzyme family; Region: APH; pfam01636 530564000057 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 530564000058 Zinc-dependent metalloprotease; MMP_like sub-family 2. A group of bacterial metalloproteinase domains similar to matrix metalloproteinases and astacin; Region: ZnMc_MMP_like_2; cd04276 530564000059 active site 530564000060 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 530564000061 Nitrogen regulatory protein P-II; Region: P-II; smart00938 530564000062 Predicted rRNA methylase (SpoU class) [Translation, ribosomal structure and biogenesis]; Region: CspR; COG0219 530564000063 DNA polymerase II large subunit; Validated; Region: PRK04023 530564000064 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 530564000065 Predicted peptidase [General function prediction only]; Region: COG4099 530564000066 coproporphyrinogen III oxidase; Provisional; Region: PRK08599 530564000067 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 530564000068 FeS/SAM binding site; other site 530564000069 HemN C-terminal domain; Region: HemN_C; pfam06969 530564000070 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 530564000071 Family description; Region: VCBS; pfam13517 530564000072 Family description; Region: VCBS; pfam13517 530564000073 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 530564000074 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 530564000075 DEAD_2; Region: DEAD_2; pfam06733 530564000076 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 530564000077 Uncharacterized protein conserved in archaea [Function unknown]; Region: COG2881 530564000078 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 530564000079 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 530564000080 inhibitor-cofactor binding pocket; inhibition site 530564000081 pyridoxal 5'-phosphate binding site [chemical binding]; other site 530564000082 catalytic residue [active] 530564000083 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 530564000084 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 530564000085 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 530564000086 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 530564000087 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 530564000088 RNA binding site [nucleotide binding]; other site 530564000089 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 530564000090 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 530564000091 active site 530564000092 metal binding site [ion binding]; metal-binding site 530564000093 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 530564000094 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 530564000095 ATP binding site [chemical binding]; other site 530564000096 Mg2+ binding site [ion binding]; other site 530564000097 G-X-G motif; other site 530564000098 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 530564000099 anti sigma factor interaction site; other site 530564000100 regulatory phosphorylation site [posttranslational modification]; other site 530564000101 putative acetyltransferase; Provisional; Region: PRK03624 530564000102 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 530564000103 Coenzyme A binding pocket [chemical binding]; other site 530564000104 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564000105 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 530564000106 Catalytic domain of Protein Kinases; Region: PKc; cd00180 530564000107 active site 530564000108 ATP binding site [chemical binding]; other site 530564000109 substrate binding site [chemical binding]; other site 530564000110 activation loop (A-loop); other site 530564000111 PEGA domain; Region: PEGA; pfam08308 530564000112 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 530564000113 Leucine rich repeat; Region: LRR_8; pfam13855 530564000114 Leucine-rich repeats; other site 530564000115 Substrate binding site [chemical binding]; other site 530564000116 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 530564000117 Leucine-rich repeats; other site 530564000118 Substrate binding site [chemical binding]; other site 530564000119 Leucine rich repeat; Region: LRR_8; pfam13855 530564000120 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 530564000121 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 530564000122 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 530564000123 GXGXG domain. This domain of unknown function is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS), in subunit C of tungsten formylmethanofuran dehydrogenase (FwdC) and in subunit C of molybdenum formylmethanofuran...; Region: GXGXG; cl00239 530564000124 domain_subunit interface; other site 530564000125 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 530564000126 active site 530564000127 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 530564000128 formylmethanofuran dehydrogenase subunit A; Region: one_C_dehyd_A; TIGR03121 530564000129 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 530564000130 active site 530564000131 DinB superfamily; Region: DinB_2; pfam12867 530564000132 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 530564000133 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 530564000134 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 530564000135 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 530564000136 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 530564000137 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 530564000138 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 530564000139 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 530564000140 intersubunit interface [polypeptide binding]; other site 530564000141 active site 530564000142 catalytic residue [active] 530564000143 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 530564000144 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 530564000145 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 530564000146 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 530564000147 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 530564000148 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 530564000149 metal binding site [ion binding]; metal-binding site 530564000150 active site 530564000151 I-site; other site 530564000152 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 530564000153 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 530564000154 ApbE family; Region: ApbE; pfam02424 530564000155 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 530564000156 PEGA domain; Region: PEGA; pfam08308 530564000157 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 530564000158 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 530564000159 DsbD alpha interface [polypeptide binding]; other site 530564000160 catalytic residues [active] 530564000161 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 530564000162 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 530564000163 purine monophosphate binding site [chemical binding]; other site 530564000164 dimer interface [polypeptide binding]; other site 530564000165 putative catalytic residues [active] 530564000166 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 530564000167 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; cl03362 530564000168 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 530564000169 EamA-like transporter family; Region: EamA; pfam00892 530564000170 EamA-like transporter family; Region: EamA; pfam00892 530564000171 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 530564000172 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 530564000173 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 530564000174 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 530564000175 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 530564000176 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 530564000177 active site 530564000178 metal binding site [ion binding]; metal-binding site 530564000179 Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta) [Lipid metabolism]; Region: COG4799 530564000180 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 530564000181 Acetyl-CoA carboxylase alpha subunit [Lipid metabolism]; Region: AccA; cl17345 530564000182 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 530564000183 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 530564000184 substrate binding site [chemical binding]; other site 530564000185 oxyanion hole (OAH) forming residues; other site 530564000186 trimer interface [polypeptide binding]; other site 530564000187 Response regulator receiver domain; Region: Response_reg; pfam00072 530564000188 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564000189 active site 530564000190 phosphorylation site [posttranslational modification] 530564000191 intermolecular recognition site; other site 530564000192 dimerization interface [polypeptide binding]; other site 530564000193 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 530564000194 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 530564000195 dimer interface [polypeptide binding]; other site 530564000196 active site 530564000197 glycine-pyridoxal phosphate binding site [chemical binding]; other site 530564000198 folate binding site [chemical binding]; other site 530564000199 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 530564000200 Catalytic domain of Protein Kinases; Region: PKc; cd00180 530564000201 active site 530564000202 ATP binding site [chemical binding]; other site 530564000203 substrate binding site [chemical binding]; other site 530564000204 activation loop (A-loop); other site 530564000205 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 530564000206 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 530564000207 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 530564000208 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; cl06870 530564000209 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 530564000210 Cytidylyltransferase family; Region: CTP_transf_1; pfam01148 530564000211 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 530564000212 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cl00230 530564000213 Putative undecaprenyl diphosphate synthase; Region: Prenyltransf; pfam01255 530564000214 catalytic residue [active] 530564000215 putative FPP diphosphate binding site; other site 530564000216 putative FPP binding hydrophobic cleft; other site 530564000217 dimer interface [polypeptide binding]; other site 530564000218 putative IPP diphosphate binding site; other site 530564000219 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 530564000220 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 530564000221 GDP-binding site [chemical binding]; other site 530564000222 ACT binding site; other site 530564000223 IMP binding site; other site 530564000224 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 530564000225 Bacterial sugar transferase; Region: Bac_transf; pfam02397 530564000226 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 530564000227 active site 530564000228 DNA binding site [nucleotide binding] 530564000229 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 530564000230 GIY-YIG motif/motif A; other site 530564000231 active site 530564000232 catalytic site [active] 530564000233 putative DNA binding site [nucleotide binding]; other site 530564000234 metal binding site [ion binding]; metal-binding site 530564000235 UvrB/uvrC motif; Region: UVR; pfam02151 530564000236 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 530564000237 phosphoglucomutase-2-like protein; Provisional; Region: PTZ00150 530564000238 This CD includes PGM2 (phosphoglucomutase 2) and PGM2L1 (phosphoglucomutase 2-like 1). The mammalian PGM2 is thought to be a phosphopentomutase that catalyzes the conversion of the nucleoside breakdown products, ribose-1-phosphate and...; Region: PGM2; cd05799 530564000239 active site 530564000240 substrate binding site [chemical binding]; other site 530564000241 metal binding site [ion binding]; metal-binding site 530564000242 hypothetical protein; Provisional; Region: PRK13665 530564000243 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 530564000244 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 530564000245 Prokaryotic diacylglycerol kinase; Region: DAGK_prokar; pfam01219 530564000246 Organic solvent tolerance protein; Region: OstA_C; pfam04453 530564000247 polyphosphate:nucleotide phosphotransferase, PPK2 family; Region: PPK2_rel_1; TIGR03709 530564000248 glucosamine-6-phosphate deaminase-like protein; Validated; Region: PRK02122 530564000249 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 530564000250 active site 530564000251 trimer interface [polypeptide binding]; other site 530564000252 allosteric site; other site 530564000253 active site lid [active] 530564000254 GlcNAc-PI de-N-acetylase; Region: PIG-L; pfam02585 530564000255 PSP1 C-terminal conserved region; Region: PSP1; cl00770 530564000256 Verruc_Plancto-restricted protein; Region: Plancto_Ver_chp; TIGR04138 530564000257 Class I aldolases; Region: Aldolase_Class_I; cl17187 530564000258 catalytic residue [active] 530564000259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 530564000260 Major Facilitator Superfamily; Region: MFS_1; pfam07690 530564000261 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 530564000262 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 530564000263 active site 530564000264 motif I; other site 530564000265 motif II; other site 530564000266 Planctomycetes uncharacterized domain TIGR03009; Region: plancto_dom_2 530564000267 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 530564000268 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 530564000269 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 530564000270 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 530564000271 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 530564000272 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 530564000273 ATP binding site [chemical binding]; other site 530564000274 Walker A motif; other site 530564000275 hexamer interface [polypeptide binding]; other site 530564000276 Walker B motif; other site 530564000277 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 530564000278 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 530564000279 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 530564000280 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 530564000281 SpoVG; Region: SpoVG; pfam04026 530564000282 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: PRK14608 530564000283 PQQ-like domain; Region: PQQ_2; pfam13360 530564000284 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 530564000285 Trp docking motif [polypeptide binding]; other site 530564000286 active site 530564000287 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 530564000288 Amidohydrolase; Region: Amidohydro_2; pfam04909 530564000289 active site 530564000290 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 530564000291 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 530564000292 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 530564000293 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 530564000294 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 530564000295 Sugar-transfer associated ATP-grasp; Region: ATPgrasp_ST; pfam14397 530564000296 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 530564000297 Resistant to P. syringae 6; Provisional; Region: PLN03210 530564000298 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 530564000299 coproporphyrinogen III oxidase; Validated; Region: PRK08208 530564000300 HemN C-terminal domain; Region: HemN_C; pfam06969 530564000301 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 530564000302 FeS/SAM binding site; other site 530564000303 Phosphoinositide 3-kinase (PI3K)-like family, catalytic domain; The PI3K-like catalytic domain family is part of a larger superfamily that includes the catalytic domains of other kinases such as the typical serine/threonine/tyrosine protein kinases (PKs); Region: PI3Kc_like; cl00119 530564000304 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 530564000305 Coenzyme A binding pocket [chemical binding]; other site 530564000306 UDP-galactopyranose mutase [Cell envelope biogenesis, outer membrane]; Region: Glf; COG0562 530564000307 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 530564000308 UDP-galactopyranose mutase; Region: GLF; pfam03275 530564000309 diaminopimelate decarboxylase; Provisional; Region: PRK11165 530564000310 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 530564000311 active site 530564000312 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 530564000313 substrate binding site [chemical binding]; other site 530564000314 catalytic residues [active] 530564000315 dimer interface [polypeptide binding]; other site 530564000316 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 530564000317 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 530564000318 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 530564000319 active site 530564000320 HIGH motif; other site 530564000321 KMSKS motif; other site 530564000322 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 530564000323 anticodon binding site; other site 530564000324 tRNA binding surface [nucleotide binding]; other site 530564000325 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 530564000326 dimer interface [polypeptide binding]; other site 530564000327 putative tRNA-binding site [nucleotide binding]; other site 530564000328 Menaquinone biosynthesis; Region: VitK2_biosynth; pfam02621 530564000329 menaquinone biosynthesis protein, SCO4550 family; Region: mena_SCO4550; TIGR03699 530564000330 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 530564000331 FeS/SAM binding site; other site 530564000332 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 530564000333 EF-hand domain pair; Region: EF_hand_5; pfam13499 530564000334 Ca2+ binding site [ion binding]; other site 530564000335 Adenylyl cyclase (AC) class IV-like, a subgroup of the CYTH-like superfamily; Region: CYTH-like_AC_IV-like; cd07890 530564000336 putative active site [active] 530564000337 putative metal binding residues [ion binding]; other site 530564000338 signature motif; other site 530564000339 putative triphosphate binding site [ion binding]; other site 530564000340 dimer interface [polypeptide binding]; other site 530564000341 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 530564000342 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 530564000343 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 530564000344 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 530564000345 Ligand binding site; other site 530564000346 oligomer interface; other site 530564000347 CTP synthetase; Validated; Region: pyrG; PRK05380 530564000348 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 530564000349 Catalytic site [active] 530564000350 active site 530564000351 UTP binding site [chemical binding]; other site 530564000352 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 530564000353 active site 530564000354 putative oxyanion hole; other site 530564000355 catalytic triad [active] 530564000356 Domain of unknown function (DUF1844); Region: DUF1844; pfam08899 530564000357 Predicted exporters of the RND superfamily [General function prediction only]; Region: COG1033 530564000358 NYN ribonuclease and ATPase of PhoH family domains [General function prediction only]; Region: COG1875 530564000359 PIN domain of bacterial Smg6-like homologs with PhoH-like ATPase domains; Region: PIN_PhoHL-ATPase; cd09883 530564000360 putative active site [active] 530564000361 PhoH-like protein; Region: PhoH; pfam02562 530564000362 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 530564000363 Glycosyltransferase family 9 (heptosyltransferase); Region: Glyco_transf_9; pfam01075 530564000364 putative active site [active] 530564000365 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 530564000366 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 530564000367 active site 530564000368 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 530564000369 substrate binding site [chemical binding]; other site 530564000370 active site 530564000371 Patatin-like phospholipase; includes PNPLA8, PNPLA9, and Pat17; Region: Pat17_PNPLA8_PNPLA9_like; cd07199 530564000372 active site 530564000373 nucleophile elbow; other site 530564000374 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 530564000375 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 530564000376 structural tetrad; other site 530564000377 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 530564000378 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 530564000379 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 530564000380 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 530564000381 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 530564000382 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 530564000383 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 530564000384 Protein of unknown function DUF116; Region: DUF116; pfam01976 530564000385 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 530564000386 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 530564000387 substrate binding pocket [chemical binding]; other site 530564000388 chain length determination region; other site 530564000389 substrate-Mg2+ binding site; other site 530564000390 catalytic residues [active] 530564000391 aspartate-rich region 1; other site 530564000392 active site lid residues [active] 530564000393 aspartate-rich region 2; other site 530564000394 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 530564000395 MASE1; Region: MASE1; cl17823 530564000396 PAS fold; Region: PAS_4; pfam08448 530564000397 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 530564000398 putative active site [active] 530564000399 heme pocket [chemical binding]; other site 530564000400 Protein of unknown function (DUF3422); Region: DUF3422; cl02073 530564000401 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 530564000402 dimer interface [polypeptide binding]; other site 530564000403 phosphorylation site [posttranslational modification] 530564000404 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 530564000405 ATP binding site [chemical binding]; other site 530564000406 Mg2+ binding site [ion binding]; other site 530564000407 G-X-G motif; other site 530564000408 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 530564000409 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564000410 active site 530564000411 phosphorylation site [posttranslational modification] 530564000412 intermolecular recognition site; other site 530564000413 dimerization interface [polypeptide binding]; other site 530564000414 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 530564000415 DNA binding residues [nucleotide binding] 530564000416 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 530564000417 active site 530564000418 HIGH motif; other site 530564000419 nucleotide binding site [chemical binding]; other site 530564000420 active site 530564000421 KMSKS motif; other site 530564000422 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 530564000423 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564000424 active site 530564000425 phosphorylation site [posttranslational modification] 530564000426 intermolecular recognition site; other site 530564000427 dimerization interface [polypeptide binding]; other site 530564000428 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 530564000429 DNA binding site [nucleotide binding] 530564000430 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 530564000431 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564000432 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564000433 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564000434 Predicted periplasmic protein (DUF2092); Region: DUF2092; cl17607 530564000435 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 530564000436 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 530564000437 catalytic residues [active] 530564000438 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564000439 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 530564000440 Sulfatase; Region: Sulfatase; cl17466 530564000441 Zn-dependent carboxypeptidase [Amino acid transport and metabolism]; Region: COG2317 530564000442 Peptidase family M32 includes thermostable carboxypeptidases TaqCP and PfuCP; Region: M32_Taq; cd06460 530564000443 active site 530564000444 Zn binding site [ion binding]; other site 530564000445 Domain of unknown function (DUF1848); Region: DUF1848; pfam08902 530564000446 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 530564000447 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 530564000448 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 530564000449 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564000450 Transcriptional regulator [Transcription]; Region: LysR; COG0583 530564000451 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 530564000452 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 530564000453 dimerization interface [polypeptide binding]; other site 530564000454 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 530564000455 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 530564000456 active site 530564000457 dimer interface [polypeptide binding]; other site 530564000458 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 530564000459 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 530564000460 active site 530564000461 FMN binding site [chemical binding]; other site 530564000462 substrate binding site [chemical binding]; other site 530564000463 3Fe-4S cluster binding site [ion binding]; other site 530564000464 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 530564000465 domain interface; other site 530564000466 glutamate synthase subunit beta; Reviewed; Region: gltD; PRK12810 530564000467 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 530564000468 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564000469 large-conductance mechanosensitive channel; Provisional; Region: mscL; PRK13952 530564000470 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 530564000471 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 530564000472 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 530564000473 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 530564000474 Walker A/P-loop; other site 530564000475 ATP binding site [chemical binding]; other site 530564000476 Q-loop/lid; other site 530564000477 ABC transporter signature motif; other site 530564000478 Walker B; other site 530564000479 D-loop; other site 530564000480 H-loop/switch region; other site 530564000481 SCP_bacterial: SCP-like extracellular protein domain, as found in bacteria and archaea. The wider family of SCP containing proteins includes plant pathogenesis-related protein 1 (PR-1), CRISPs, mammalian cysteine-rich secretory proteins, and allergen 5...; Region: SCP_bacterial; cd05379 530564000482 Arginyl tRNA synthetase N terminal domain; Region: Arg_tRNA_synt_N; pfam03485 530564000483 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 530564000484 active site 530564000485 HIGH motif; other site 530564000486 nucleotide binding site [chemical binding]; other site 530564000487 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 530564000488 KMSK motif region; other site 530564000489 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 530564000490 tRNA binding surface [nucleotide binding]; other site 530564000491 anticodon binding site; other site 530564000492 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 530564000493 DNA methylase; Region: N6_N4_Mtase; pfam01555 530564000494 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 530564000495 dimerization interface [polypeptide binding]; other site 530564000496 putative DNA binding site [nucleotide binding]; other site 530564000497 putative Zn2+ binding site [ion binding]; other site 530564000498 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 530564000499 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 530564000500 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 530564000501 peptide binding site [polypeptide binding]; other site 530564000502 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 530564000503 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 530564000504 dimer interface [polypeptide binding]; other site 530564000505 conserved gate region; other site 530564000506 putative PBP binding loops; other site 530564000507 ABC-ATPase subunit interface; other site 530564000508 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 530564000509 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 530564000510 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 530564000511 dimer interface [polypeptide binding]; other site 530564000512 conserved gate region; other site 530564000513 putative PBP binding loops; other site 530564000514 ABC-ATPase subunit interface; other site 530564000515 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 530564000516 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 530564000517 Walker A/P-loop; other site 530564000518 ATP binding site [chemical binding]; other site 530564000519 Q-loop/lid; other site 530564000520 ABC transporter signature motif; other site 530564000521 Walker B; other site 530564000522 D-loop; other site 530564000523 H-loop/switch region; other site 530564000524 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 530564000525 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 530564000526 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 530564000527 Walker A/P-loop; other site 530564000528 ATP binding site [chemical binding]; other site 530564000529 Q-loop/lid; other site 530564000530 ABC transporter signature motif; other site 530564000531 Walker B; other site 530564000532 D-loop; other site 530564000533 H-loop/switch region; other site 530564000534 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 530564000535 Iron-binding zinc finger CDGSH type; Region: zf-CDGSH; pfam09360 530564000536 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 530564000537 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 530564000538 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 530564000539 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 530564000540 DNA binding residues [nucleotide binding] 530564000541 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 530564000542 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 530564000543 putative RNA binding site [nucleotide binding]; other site 530564000544 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 530564000545 S-adenosylmethionine binding site [chemical binding]; other site 530564000546 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 530564000547 N-terminal domain interface [polypeptide binding]; other site 530564000548 hopanoid biosynthesis associated RND transporter like protein HpnN; Region: HpnN; TIGR03480 530564000549 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 530564000550 Sterol-sensing domain of SREBP cleavage-activation; Region: Sterol-sensing; pfam12349 530564000551 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 530564000552 active site 2 [active] 530564000553 active site 1 [active] 530564000554 Putative methyltransferase; Region: Methyltransf_4; cl17290 530564000555 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564000556 Predicted membrane protein (DUF2306); Region: DUF2306; cl02232 530564000557 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564000558 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 530564000559 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564000560 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564000561 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 530564000562 binding surface 530564000563 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564000564 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564000565 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564000566 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 530564000567 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 530564000568 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 530564000569 catalytic residue [active] 530564000570 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 530564000571 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 530564000572 acyl-activating enzyme (AAE) consensus motif; other site 530564000573 AMP binding site [chemical binding]; other site 530564000574 active site 530564000575 CoA binding site [chemical binding]; other site 530564000576 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 530564000577 Major Facilitator Superfamily; Region: MFS_1; pfam07690 530564000578 putative substrate translocation pore; other site 530564000579 mercuric reductase; Validated; Region: PRK06370 530564000580 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 530564000581 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 530564000582 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 530564000583 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 530564000584 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 530564000585 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 530564000586 benzoate transport; Region: 2A0115; TIGR00895 530564000587 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 530564000588 acyl carrier protein; Provisional; Region: acpP; PRK00982 530564000589 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 530564000590 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 530564000591 dimer interface [polypeptide binding]; other site 530564000592 active site 530564000593 peptide chain release factor 2; Validated; Region: prfB; PRK00578 530564000594 PCRF domain; Region: PCRF; pfam03462 530564000595 RF-1 domain; Region: RF-1; pfam00472 530564000596 Uncharacterized protein family (UPF0157); Region: UPF0157; pfam04229 530564000597 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564000598 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 530564000599 Catalytic domain of Protein Kinases; Region: PKc; cd00180 530564000600 active site 530564000601 ATP binding site [chemical binding]; other site 530564000602 substrate binding site [chemical binding]; other site 530564000603 activation loop (A-loop); other site 530564000604 Prim_Pol: Primase-polymerase (primpol) domain of the type found in bifunctional replicases from archaeal plasmids, including ORF904 protein of the crenarchaeal plasmid pRN1 from Sulfolobus islandicus (pRN1 primpol). These primpol domains belong to the...; Region: Prim_Pol; cd04859 530564000605 polymerase nucleotide-binding site; other site 530564000606 DNA-binding residues [nucleotide binding]; DNA binding site 530564000607 nucleotide binding site [chemical binding]; other site 530564000608 primase nucleotide-binding site [nucleotide binding]; other site 530564000609 Helix-turn-helix domain; Region: HTH_17; pfam12728 530564000610 DEAD-like helicases superfamily; Region: DEXDc; smart00487 530564000611 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 530564000612 ATP binding site [chemical binding]; other site 530564000613 putative Mg++ binding site [ion binding]; other site 530564000614 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 530564000615 DNA methylase; Region: N6_N4_Mtase; pfam01555 530564000616 DNA methylase; Region: N6_N4_Mtase; pfam01555 530564000617 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 530564000618 ECF sigma factor; Region: Sigma70_ECF; pfam07638 530564000619 Catalytic domain of Protein Kinases; Region: PKc; cd00180 530564000620 active site 530564000621 ATP binding site [chemical binding]; other site 530564000622 substrate binding site [chemical binding]; other site 530564000623 activation loop (A-loop); other site 530564000624 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 530564000625 Protein of unknown function (DUF1348); Region: DUF1348; pfam07080 530564000626 SnoaL-like domain; Region: SnoaL_2; pfam12680 530564000627 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 530564000628 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 530564000629 uncharacterized peroxidase-related enzyme; Region: peroxid_rel; TIGR01926 530564000630 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 530564000631 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 530564000632 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 530564000633 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564000634 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 530564000635 Walker A motif; other site 530564000636 ATP binding site [chemical binding]; other site 530564000637 Walker B motif; other site 530564000638 arginine finger; other site 530564000639 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 530564000640 Sulfatase; Region: Sulfatase; pfam00884 530564000641 Archaeal ATPase; Region: Arch_ATPase; pfam01637 530564000642 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 530564000643 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 530564000644 AAA domain; Region: AAA_22; pfam13401 530564000645 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 530564000646 Sel1-like repeats; Region: SEL1; smart00671 530564000647 Sel1-like repeats; Region: SEL1; smart00671 530564000648 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 530564000649 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 530564000650 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 530564000651 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 530564000652 catalytic residues [active] 530564000653 catalytic nucleophile [active] 530564000654 Recombinase; Region: Recombinase; pfam07508 530564000655 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 530564000656 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 530564000657 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 530564000658 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 530564000659 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 530564000660 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 530564000661 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 530564000662 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 530564000663 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 530564000664 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 530564000665 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 530564000666 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 530564000667 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 530564000668 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 530564000669 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 530564000670 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 530564000671 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 530564000672 Catalytic domain of Protein Kinases; Region: PKc; cd00180 530564000673 active site 530564000674 ATP binding site [chemical binding]; other site 530564000675 substrate binding site [chemical binding]; other site 530564000676 activation loop (A-loop); other site 530564000677 DKNYY family; Region: DKNYY; pfam13644 530564000678 DKNYY family; Region: DKNYY; pfam13644 530564000679 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 530564000680 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 530564000681 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564000682 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 530564000683 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564000684 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564000685 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564000686 transaldolase/EF-hand domain-containing protein; Provisional; Region: PRK12309 530564000687 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564000688 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564000689 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564000690 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564000691 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564000692 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564000693 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 530564000694 diphosphate--fructose-6-phosphate 1-phosphotransferase; Provisional; Region: PRK06830 530564000695 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 530564000696 active site 530564000697 ADP/pyrophosphate binding site [chemical binding]; other site 530564000698 dimerization interface [polypeptide binding]; other site 530564000699 allosteric effector site; other site 530564000700 fructose-1,6-bisphosphate binding site; other site 530564000701 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 530564000702 RNA helicase; Region: RNA_helicase; pfam00910 530564000703 Hemin uptake protein hemP; Region: hemP; pfam10636 530564000704 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 530564000705 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 530564000706 Active Sites [active] 530564000707 Rrf2 family protein; Region: rrf2_super; TIGR00738 530564000708 Transcriptional regulator; Region: Rrf2; pfam02082 530564000709 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 530564000710 active site 530564000711 ribulose/triose binding site [chemical binding]; other site 530564000712 phosphate binding site [ion binding]; other site 530564000713 substrate (anthranilate) binding pocket [chemical binding]; other site 530564000714 product (indole) binding pocket [chemical binding]; other site 530564000715 Membrane-bound metallopeptidase [Cell division and chromosome partitioning]; Region: COG4942 530564000716 A/G-specific DNA glycosylase [DNA replication, recombination, and repair]; Region: MutY; COG1194 530564000717 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 530564000718 minor groove reading motif; other site 530564000719 helix-hairpin-helix signature motif; other site 530564000720 substrate binding pocket [chemical binding]; other site 530564000721 active site 530564000722 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 530564000723 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 530564000724 DNA binding and oxoG recognition site [nucleotide binding] 530564000725 Serine proteases of the peptidase family S9A [Amino acid transport and metabolism]; Region: COG1505 530564000726 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 530564000727 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564000728 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 530564000729 Putative esterase; Region: Esterase; pfam00756 530564000730 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 530564000731 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564000732 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 530564000733 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564000734 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564000735 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564000736 HDOD domain; Region: HDOD; pfam08668 530564000737 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 530564000738 metal binding site [ion binding]; metal-binding site 530564000739 active site 530564000740 I-site; other site 530564000741 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 530564000742 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 530564000743 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 530564000744 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 530564000745 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 530564000746 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 530564000747 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 530564000748 BNR repeat-like domain; Region: BNR_2; pfam13088 530564000749 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 530564000750 Asp-box motif; other site 530564000751 catalytic site [active] 530564000752 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4398 530564000753 FIST N domain; Region: FIST; pfam08495 530564000754 FIST C domain; Region: FIST_C; pfam10442 530564000755 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 530564000756 RNA 3' phosphate cyclase domain (class II). These proteins function as RNA cyclase to catalyze the ATP-dependent conversion of 3'-phosphate to a 2'.3'-cyclic phosphodiester at the end of RNA molecule. A conserved catalytic histidine...; Region: RNA_Cyclase_Class_II; cd00874 530564000757 putative active site [active] 530564000758 adenylation catalytic residue [active] 530564000759 hypothetical protein; Reviewed; Region: PRK09588 530564000760 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 530564000761 TROVE domain; Region: TROVE; pfam05731 530564000762 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 530564000763 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 530564000764 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564000765 Walker A motif; other site 530564000766 ATP binding site [chemical binding]; other site 530564000767 Walker B motif; other site 530564000768 arginine finger; other site 530564000769 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 530564000770 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 530564000771 metal ion-dependent adhesion site (MIDAS); other site 530564000772 TraB family; Region: TraB; cl12050 530564000773 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 530564000774 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 530564000775 Walker A motif; other site 530564000776 ATP binding site [chemical binding]; other site 530564000777 Walker B motif; other site 530564000778 arginine finger; other site 530564000779 Uncharacterized conserved protein [Function unknown]; Region: COG4279 530564000780 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 530564000781 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 530564000782 RNA binding site [nucleotide binding]; other site 530564000783 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 530564000784 RNA binding site [nucleotide binding]; other site 530564000785 S1_RPS1_repeat_hs4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_hs4; cd05692 530564000786 RNA binding site [nucleotide binding]; other site 530564000787 Putative phosphatase (DUF442); Region: DUF442; cl17385 530564000788 acyl carrier protein; Provisional; Region: acpP; PRK00982 530564000789 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 530564000790 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 530564000791 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 530564000792 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 530564000793 hypothetical protein; Provisional; Region: PRK05208 530564000794 Phenylalanyl-tRNA synthetase beta subunit [Translation, ribosomal structure and biogenesis]; Region: PheT; COG0072 530564000795 B3/4 domain; Region: B3_4; pfam03483 530564000796 tRNA synthetase B5 domain; Region: B5; smart00874 530564000797 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 530564000798 motif 1; other site 530564000799 dimer interface [polypeptide binding]; other site 530564000800 active site 530564000801 motif 2; other site 530564000802 motif 3; other site 530564000803 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 530564000804 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 530564000805 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 530564000806 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 530564000807 dimer interface [polypeptide binding]; other site 530564000808 motif 1; other site 530564000809 active site 530564000810 motif 2; other site 530564000811 motif 3; other site 530564000812 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 530564000813 23S rRNA binding site [nucleotide binding]; other site 530564000814 L21 binding site [polypeptide binding]; other site 530564000815 L13 binding site [polypeptide binding]; other site 530564000816 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 530564000817 argininosuccinate lyase; Provisional; Region: PRK00855 530564000818 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 530564000819 active sites [active] 530564000820 tetramer interface [polypeptide binding]; other site 530564000821 HEAT repeats; Region: HEAT_2; pfam13646 530564000822 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 530564000823 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564000824 Walker A motif; other site 530564000825 ATP binding site [chemical binding]; other site 530564000826 Walker B motif; other site 530564000827 arginine finger; other site 530564000828 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 530564000829 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 530564000830 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 530564000831 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 530564000832 tRNA; other site 530564000833 putative tRNA binding site [nucleotide binding]; other site 530564000834 putative NADP binding site [chemical binding]; other site 530564000835 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 530564000836 Putative transcriptional regulators (Ypuh-like); Region: DUF387; pfam04079 530564000837 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 530564000838 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 530564000839 P-loop; other site 530564000840 Magnesium ion binding site [ion binding]; other site 530564000841 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 530564000842 Magnesium ion binding site [ion binding]; other site 530564000843 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeC; cd03378 530564000844 active site clefts [active] 530564000845 zinc binding site [ion binding]; other site 530564000846 dimer interface [polypeptide binding]; other site 530564000847 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 530564000848 Sulfatase; Region: Sulfatase; pfam00884 530564000849 G8 domain; Region: G8; pfam10162 530564000850 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 530564000851 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564000852 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 530564000853 Alpha-Ketoglutaric Semialdehyde Dehydrogenase; Region: ALDH_KGSADH; cd07129 530564000854 dimer interface [polypeptide binding]; other site 530564000855 NADP binding site [chemical binding]; other site 530564000856 catalytic residues [active] 530564000857 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 530564000858 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 530564000859 Predicted membrane protein [Function unknown]; Region: COG4325 530564000860 Predicted membrane protein (DUF2254); Region: DUF2254; pfam10011 530564000861 deoxyhypusine synthase-like protein; Provisional; Region: PRK02492 530564000862 deoxyhypusine synthase; Region: dhys; TIGR00321 530564000863 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 530564000864 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 530564000865 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 530564000866 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 530564000867 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 530564000868 metal ion-dependent adhesion site (MIDAS); other site 530564000869 Possible lysine decarboxylase; Region: Lysine_decarbox; cl00695 530564000870 PhoD-like phosphatase; Region: PhoD; pfam09423 530564000871 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 530564000872 putative active site [active] 530564000873 putative metal binding site [ion binding]; other site 530564000874 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 530564000875 Calcium binding; Region: Calci_bind_CcbP; pfam11535 530564000876 TENA/THI-4/PQQC family; Region: TENA_THI-4; cl15243 530564000877 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 530564000878 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; cl01747 530564000879 peptidase PmbA; Provisional; Region: PRK11040 530564000880 Protein of unknown function (DUF1040); Region: DUF1040; cl01176 530564000881 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 530564000882 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 530564000883 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 530564000884 non-specific DNA binding site [nucleotide binding]; other site 530564000885 salt bridge; other site 530564000886 sequence-specific DNA binding site [nucleotide binding]; other site 530564000887 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 530564000888 DNA-binding interface [nucleotide binding]; DNA binding site 530564000889 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 530564000890 multiple promoter invertase; Provisional; Region: mpi; PRK13413 530564000891 catalytic residues [active] 530564000892 catalytic nucleophile [active] 530564000893 Presynaptic Site I dimer interface [polypeptide binding]; other site 530564000894 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 530564000895 Synaptic Flat tetramer interface [polypeptide binding]; other site 530564000896 Synaptic Site I dimer interface [polypeptide binding]; other site 530564000897 DNA binding site [nucleotide binding] 530564000898 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 530564000899 DNA-binding interface [nucleotide binding]; DNA binding site 530564000900 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 530564000901 sequence-specific DNA binding site [nucleotide binding]; other site 530564000902 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 530564000903 dimerization interface [polypeptide binding]; other site 530564000904 putative DNA binding site [nucleotide binding]; other site 530564000905 putative Zn2+ binding site [ion binding]; other site 530564000906 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 530564000907 active site residue [active] 530564000908 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 530564000909 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 530564000910 active site residue [active] 530564000911 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 530564000912 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 530564000913 active site residue [active] 530564000914 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 530564000915 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 530564000916 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 530564000917 FOG: CBS domain [General function prediction only]; Region: COG0517 530564000918 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 530564000919 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 530564000920 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 530564000921 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 530564000922 catalytic residues [active] 530564000923 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 530564000924 anti sigma factor interaction site; other site 530564000925 regulatory phosphorylation site [posttranslational modification]; other site 530564000926 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 530564000927 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564000928 active site 530564000929 phosphorylation site [posttranslational modification] 530564000930 intermolecular recognition site; other site 530564000931 dimerization interface [polypeptide binding]; other site 530564000932 Histidine kinase-like ATPase domain; Region: HATPase_c_2; pfam13581 530564000933 ATP binding site [chemical binding]; other site 530564000934 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cl00075 530564000935 G-X-G motif; other site 530564000936 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide acyltransferase (E2) component, and related enzymes [Energy production and conversion]; Region: AceF; COG0508 530564000937 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 530564000938 E3 interaction surface; other site 530564000939 lipoyl attachment site [posttranslational modification]; other site 530564000940 lipoyl synthase; Provisional; Region: PRK05481 530564000941 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 530564000942 FeS/SAM binding site; other site 530564000943 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; cl14057 530564000944 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 530564000945 SmpB-tmRNA interface; other site 530564000946 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 530564000947 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 530564000948 Walker A/P-loop; other site 530564000949 ATP binding site [chemical binding]; other site 530564000950 Q-loop/lid; other site 530564000951 ABC transporter signature motif; other site 530564000952 Walker B; other site 530564000953 D-loop; other site 530564000954 H-loop/switch region; other site 530564000955 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 530564000956 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 530564000957 FtsX-like permease family; Region: FtsX; pfam02687 530564000958 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 530564000959 von Willebrand factor type A domain; Region: VWA_2; pfam13519 530564000960 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 530564000961 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 530564000962 active site 530564000963 Membrane-bound serine protease (ClpP class) [Posttranslational modification, protein turnover, chaperones]; Region: NfeD; COG1030 530564000964 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 530564000965 rRNA binding site [nucleotide binding]; other site 530564000966 predicted 30S ribosome binding site; other site 530564000967 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 530564000968 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 530564000969 phosphopeptide binding site; other site 530564000970 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 530564000971 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 530564000972 Coenzyme A binding pocket [chemical binding]; other site 530564000973 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 530564000974 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 530564000975 active site 530564000976 ATP binding site [chemical binding]; other site 530564000977 substrate binding site [chemical binding]; other site 530564000978 activation loop (A-loop); other site 530564000979 Tubulin like; Region: Tubulin_2; pfam13809 530564000980 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 530564000981 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 530564000982 phosphopeptide binding site; other site 530564000983 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 530564000984 Response regulator receiver domain; Region: Response_reg; pfam00072 530564000985 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 530564000986 active site 530564000987 phosphorylation site [posttranslational modification] 530564000988 intermolecular recognition site; other site 530564000989 dimerization interface [polypeptide binding]; other site 530564000990 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 530564000991 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 530564000992 metal binding site [ion binding]; metal-binding site 530564000993 active site 530564000994 I-site; other site 530564000995 FOG: CBS domain [General function prediction only]; Region: COG0517 530564000996 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 530564000997 Sugar nucleotidyl transferase; Region: NTP_transf_4; pfam13562 530564000998 UDP-N-acetylglucosamine diphosphorylase/glucosamine-1-phosphate N-acetyltransferase; Region: alt_bact_glmU; TIGR03991 530564000999 Uncharacterized proteins, Left-handed parallel beta-Helix (LbH) domain: Members in this group are uncharacterized bacterial proteins containing a LbH domain with multiple turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif...; Region: LbH_unknown; cd05635 530564001000 Four helix bundle sensory module for signal transduction; Region: 4HB_MCP_1; pfam12729 530564001001 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 530564001002 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 530564001003 dimerization interface [polypeptide binding]; other site 530564001004 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 530564001005 dimer interface [polypeptide binding]; other site 530564001006 phosphorylation site [posttranslational modification] 530564001007 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 530564001008 ATP binding site [chemical binding]; other site 530564001009 Mg2+ binding site [ion binding]; other site 530564001010 G-X-G motif; other site 530564001011 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 530564001012 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564001013 active site 530564001014 phosphorylation site [posttranslational modification] 530564001015 intermolecular recognition site; other site 530564001016 dimerization interface [polypeptide binding]; other site 530564001017 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564001018 Walker A motif; other site 530564001019 ATP binding site [chemical binding]; other site 530564001020 Walker B motif; other site 530564001021 arginine finger; other site 530564001022 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 530564001023 LexA repressor; Validated; Region: PRK00215 530564001024 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 530564001025 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 530564001026 Catalytic site [active] 530564001027 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 530564001028 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 530564001029 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 530564001030 NAD binding site [chemical binding]; other site 530564001031 ATP-grasp domain; Region: ATP-grasp; pfam02222 530564001032 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 530564001033 HEAT repeats; Region: HEAT_2; pfam13646 530564001034 HEAT repeats; Region: HEAT_2; pfam13646 530564001035 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 530564001036 Cytochrome c; Region: Cytochrom_C; pfam00034 530564001037 putative heme peroxidase; Provisional; Region: PRK12276 530564001038 Deoxyribodipyrimidine photo-lyase-related protein; Region: DPRP; pfam04244 530564001039 Uncharacterized protein related to deoxyribodipyrimidine photolyase [General function prediction only]; Region: COG3046 530564001040 Methyltransferase domain; Region: Methyltransf_31; pfam13847 530564001041 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 530564001042 S-adenosylmethionine binding site [chemical binding]; other site 530564001043 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 530564001044 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 530564001045 Uncharacterized conserved protein [Function unknown]; Region: COG2006 530564001046 Domain of unknown function (DUF362); Region: DUF362; pfam04015 530564001047 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 530564001048 Ferredoxin [Energy production and conversion]; Region: COG1146 530564001049 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox_3; pfam13738 530564001050 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 530564001051 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 530564001052 Pup-ligase protein; Region: Pup_ligase; cl15463 530564001053 Pup-ligase protein; Region: Pup_ligase; cl15463 530564001054 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 530564001055 bacterial and archael members of the sulfite oxidase (SO) family of molybdopterin binding domains. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and...; Region: arch_bact_SO_family_Moco; cd02109 530564001056 Moco binding site; other site 530564001057 metal coordination site [ion binding]; other site 530564001058 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 530564001059 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 530564001060 active site 530564001061 metal binding site [ion binding]; metal-binding site 530564001062 8-amino-7-oxononanoate synthase; Reviewed; Region: PRK05958 530564001063 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 530564001064 catalytic residue [active] 530564001065 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 530564001066 DNA methylase; Region: N6_N4_Mtase; cl17433 530564001067 gamma-glutamyl kinase; Provisional; Region: PRK05429 530564001068 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 530564001069 nucleotide binding site [chemical binding]; other site 530564001070 homotetrameric interface [polypeptide binding]; other site 530564001071 putative phosphate binding site [ion binding]; other site 530564001072 putative allosteric binding site; other site 530564001073 PUA domain; Region: PUA; pfam01472 530564001074 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 530564001075 Putative Flp pilus-assembly TadE/G-like; Region: Tad; pfam13400 530564001076 Putative Tad-like Flp pilus-assembly; Region: Tad_C; pfam09977 530564001077 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 530564001078 metal ion-dependent adhesion site (MIDAS); other site 530564001079 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 530564001080 active site 530564001081 multimer interface [polypeptide binding]; other site 530564001082 Domain of unknown function DUF11; Region: DUF11; pfam01345 530564001083 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 530564001084 Guanosine polyphosphate pyrophosphohydrolases/synthetases [Signal transduction mechanisms / Transcription]; Region: SpoT; COG0317 530564001085 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 530564001086 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 530564001087 active site 530564001088 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 530564001089 active site 530564001090 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 530564001091 Ribosomal protein S27; Region: Ribosomal_S27e; cl00897 530564001092 Uncharacterized conserved protein [Function unknown]; Region: COG0585 530564001093 Pseudouridine synthases catalyze the isomerization of specific uridines in an RNA molecule to pseudouridines (5-ribosyluracil, psi); Region: PseudoU_synth; cl00130 530564001094 active site 530564001095 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 530564001096 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 530564001097 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 530564001098 Walker A motif; other site 530564001099 ATP binding site [chemical binding]; other site 530564001100 Walker B motif; other site 530564001101 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 530564001102 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 530564001103 Walker A motif; other site 530564001104 ATP binding site [chemical binding]; other site 530564001105 Walker B motif; other site 530564001106 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 530564001107 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 530564001108 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 530564001109 Walker A motif; other site 530564001110 ATP binding site [chemical binding]; other site 530564001111 Walker B motif; other site 530564001112 type II secretion system protein F; Region: GspF; TIGR02120 530564001113 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 530564001114 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 530564001115 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 530564001116 Dynein heavy chain, N-terminal region 2; Region: DHC_N2; pfam08393 530564001117 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 530564001118 nucleoside/Zn binding site; other site 530564001119 dimer interface [polypeptide binding]; other site 530564001120 catalytic motif [active] 530564001121 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 530564001122 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 530564001123 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 530564001124 NAD(P) binding site [chemical binding]; other site 530564001125 active site 530564001126 Predicted integral membrane protein [Function unknown]; Region: COG5652 530564001127 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 530564001128 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 530564001129 inhibitor site; inhibition site 530564001130 active site 530564001131 dimer interface [polypeptide binding]; other site 530564001132 catalytic residue [active] 530564001133 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 530564001134 Coenzyme A binding pocket [chemical binding]; other site 530564001135 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 530564001136 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 530564001137 Ligand binding site; other site 530564001138 Putative Catalytic site; other site 530564001139 DXD motif; other site 530564001140 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 530564001141 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 530564001142 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 530564001143 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 530564001144 protein binding site [polypeptide binding]; other site 530564001145 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 530564001146 Catalytic dyad [active] 530564001147 YbaK-like. The YbaK family of deacylase domains includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting homologs, YbaK, ProX, and PrdX. The primary function of INS is to hydrolyze...; Region: YbaK_like; cl00022 530564001148 putative deacylase active site [active] 530564001149 Predicted integral membrane protein [Function unknown]; Region: COG5650 530564001150 Alpha/beta hydrolase of unknown function (DUF900); Region: DUF900; pfam05990 530564001151 Lipase (class 2); Region: Lipase_2; pfam01674 530564001152 Sulfatase; Region: Sulfatase; cl17466 530564001153 lipid kinase; Reviewed; Region: PRK13054 530564001154 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 530564001155 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; cl17465 530564001156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2258 530564001157 MOSC domain; Region: MOSC; pfam03473 530564001158 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 530564001159 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 530564001160 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 530564001161 DNA binding residues [nucleotide binding] 530564001162 Response regulator receiver domain; Region: Response_reg; pfam00072 530564001163 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564001164 active site 530564001165 phosphorylation site [posttranslational modification] 530564001166 intermolecular recognition site; other site 530564001167 dimerization interface [polypeptide binding]; other site 530564001168 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 530564001169 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 530564001170 active site 530564001171 FOG: WD40 repeat [General function prediction only]; Region: COG2319 530564001172 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 530564001173 structural tetrad; other site 530564001174 Protein of unknown function (DUF1475); Region: DUF1475; pfam07343 530564001175 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 530564001176 active site 530564001177 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 530564001178 Bacillus subtilis YvnB and related proteins, metallophosphatase domain; Region: MPP_YvnB; cd07399 530564001179 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 530564001180 putative active site [active] 530564001181 putative metal binding site [ion binding]; other site 530564001182 Mannose-6-phosphate isomerase [Carbohydrate transport and metabolism]; Region: {ManC}; COG0662 530564001183 Domain of unknown function (DUF4105); Region: DUF4105; pfam13387 530564001184 Thiamine pyrophosphate-requiring enzymes [acetolactate synthase, pyruvate dehydrogenase (cytochrome), glyoxylate carboligase, phosphonopyruvate decarboxylase] [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvB; COG0028 530564001185 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 530564001186 PYR/PP interface [polypeptide binding]; other site 530564001187 dimer interface [polypeptide binding]; other site 530564001188 TPP binding site [chemical binding]; other site 530564001189 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 530564001190 Thiamine pyrophosphate (TPP) family, BFDC subfamily, TPP-binding module; composed of proteins similar to Pseudomonas putida benzoylformate decarboxylase (BFDC). P. putida BFDC plays a role in the mandelate pathway, catalyzing the conversion of...; Region: TPP_BFDC; cd02002 530564001191 TPP-binding site [chemical binding]; other site 530564001192 dimer interface [polypeptide binding]; other site 530564001193 N-formylglutamate amidohydrolase; Region: FGase; cl01522 530564001194 Alkyladenine DNA glycosylase catalyzes the first step in base excision repair; Region: AAG; cd00540 530564001195 active site 530564001196 DNA binding site [nucleotide binding] 530564001197 vitamin B12-dependent ribonucleotide reductase; Validated; Region: PRK06556 530564001198 Class II vitamin B12-dependent ribonucleotide reductase; Region: Ribonuc_red_2_N; pfam08471 530564001199 Class II ribonucleotide reductase, dimeric form; Region: RNR_II_dimer; cd02888 530564001200 active site 530564001201 dimer interface [polypeptide binding]; other site 530564001202 effector binding site; other site 530564001203 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 530564001204 TSCPD domain; Region: TSCPD; pfam12637 530564001205 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 530564001206 nucleotide binding site/active site [active] 530564001207 HIT family signature motif; other site 530564001208 catalytic residue [active] 530564001209 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 530564001210 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 530564001211 putative NAD(P) binding site [chemical binding]; other site 530564001212 putative substrate binding site [chemical binding]; other site 530564001213 catalytic Zn binding site [ion binding]; other site 530564001214 structural Zn binding site [ion binding]; other site 530564001215 dimer interface [polypeptide binding]; other site 530564001216 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 530564001217 Putative esterase; Region: Esterase; pfam00756 530564001218 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 530564001219 MarR family; Region: MarR_2; pfam12802 530564001220 Protein of unknown function (DUF2459); Region: DUF2459; pfam09601 530564001221 Fatty acid desaturase; Region: FA_desaturase; pfam00487 530564001222 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 530564001223 Di-iron ligands [ion binding]; other site 530564001224 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 530564001225 Bacterial Ig-like domain; Region: Big_5; pfam13205 530564001226 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 530564001227 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 530564001228 ABC transporter; Region: ABC_tran_2; pfam12848 530564001229 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 530564001230 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 530564001231 putative rRNA binding site [nucleotide binding]; other site 530564001232 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 530564001233 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 530564001234 Amidohydrolase; Region: Amidohydro_2; pfam04909 530564001235 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 530564001236 Catalytic domain of Protein Kinases; Region: PKc; cd00180 530564001237 active site 530564001238 ATP binding site [chemical binding]; other site 530564001239 substrate binding site [chemical binding]; other site 530564001240 activation loop (A-loop); other site 530564001241 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 530564001242 cyclase homology domain; Region: CHD; cd07302 530564001243 nucleotidyl binding site; other site 530564001244 metal binding site [ion binding]; metal-binding site 530564001245 dimer interface [polypeptide binding]; other site 530564001246 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 530564001247 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 530564001248 Na binding site [ion binding]; other site 530564001249 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564001250 BON domain; Region: BON; pfam04972 530564001251 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 530564001252 Uncharacterized small protein (DUF2292); Region: DUF2292; pfam10055 530564001253 ABC-type sulfate/molybdate transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: CysA; COG1118 530564001254 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 530564001255 Walker A/P-loop; other site 530564001256 ATP binding site [chemical binding]; other site 530564001257 Q-loop/lid; other site 530564001258 ABC transporter signature motif; other site 530564001259 Walker B; other site 530564001260 D-loop; other site 530564001261 H-loop/switch region; other site 530564001262 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 530564001263 dimer interface [polypeptide binding]; other site 530564001264 conserved gate region; other site 530564001265 putative PBP binding loops; other site 530564001266 ABC-ATPase subunit interface; other site 530564001267 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 530564001268 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 530564001269 dimer interface [polypeptide binding]; other site 530564001270 conserved gate region; other site 530564001271 putative PBP binding loops; other site 530564001272 ABC-ATPase subunit interface; other site 530564001273 ABC-type sulfate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: Sbp; COG1613 530564001274 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 530564001275 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 530564001276 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564001277 Walker A motif; other site 530564001278 ATP binding site [chemical binding]; other site 530564001279 Walker B motif; other site 530564001280 arginine finger; other site 530564001281 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 530564001282 Acinetobacter rhombotarget A; Region: GlyGly_RbtA; TIGR04212 530564001283 Uncharacterized protein involved in tolerance to divalent cations [Inorganic ion transport and metabolism]; Region: CutA; COG1324 530564001284 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 530564001285 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 530564001286 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 530564001287 threonine synthase; Validated; Region: PRK06260 530564001288 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 530564001289 homodimer interface [polypeptide binding]; other site 530564001290 pyridoxal 5'-phosphate binding site [chemical binding]; other site 530564001291 catalytic residue [active] 530564001292 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 530564001293 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 530564001294 Signal peptidase I [Intracellular trafficking and secretion]; Region: LepB; COG0681 530564001295 Catalytic site [active] 530564001296 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 530564001297 ABC-type (unclassified) transport system, ATPase component [General function prediction only]; Region: YhbG; COG1137 530564001298 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 530564001299 Walker A/P-loop; other site 530564001300 ATP binding site [chemical binding]; other site 530564001301 Q-loop/lid; other site 530564001302 ABC transporter signature motif; other site 530564001303 Walker B; other site 530564001304 D-loop; other site 530564001305 H-loop/switch region; other site 530564001306 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564001307 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 530564001308 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 530564001309 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564001310 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 530564001311 FOG: WD40 repeat [General function prediction only]; Region: COG2319 530564001312 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 530564001313 structural tetrad; other site 530564001314 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564001315 Sulfatase; Region: Sulfatase; cl17466 530564001316 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564001317 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564001318 Fic family protein [Function unknown]; Region: COG3177 530564001319 Fic/DOC family N-terminal; Region: Fic_N; pfam13784 530564001320 Fic/DOC family; Region: Fic; pfam02661 530564001321 Methyltransferase domain; Region: Methyltransf_23; pfam13489 530564001322 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 530564001323 S-adenosylmethionine binding site [chemical binding]; other site 530564001324 Tubby C 2; Region: Tub_2; cl02043 530564001325 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 530564001326 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 530564001327 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 530564001328 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 530564001329 D-Alanine aminotransferase (D-AAT_like): D-amino acid aminotransferase catalyzes transamination between D-amino acids and their respective alpha-keto acids. It plays a major role in the synthesis of bacterial cell wall components like D-alanine and...; Region: D-AAT_like; cd01558 530564001330 homodimer interface [polypeptide binding]; other site 530564001331 substrate-cofactor binding pocket; other site 530564001332 pyridoxal 5'-phosphate binding site [chemical binding]; other site 530564001333 catalytic residue [active] 530564001334 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 530564001335 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 530564001336 Walker A/P-loop; other site 530564001337 ATP binding site [chemical binding]; other site 530564001338 Q-loop/lid; other site 530564001339 ABC transporter signature motif; other site 530564001340 Walker B; other site 530564001341 D-loop; other site 530564001342 H-loop/switch region; other site 530564001343 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 530564001344 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 530564001345 FtsX-like permease family; Region: FtsX; pfam02687 530564001346 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 530564001347 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 530564001348 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 530564001349 dimer interface [polypeptide binding]; other site 530564001350 putative anticodon binding site; other site 530564001351 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 530564001352 motif 1; other site 530564001353 active site 530564001354 motif 2; other site 530564001355 motif 3; other site 530564001356 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 530564001357 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 530564001358 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 530564001359 Helix-Turn-Helix DNA binding domain of transcription regulators from the MerR superfamily; Region: HTH_MerR-SF; cl02600 530564001360 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 530564001361 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564001362 binding surface 530564001363 TPR motif; other site 530564001364 TPR repeat; Region: TPR_11; pfam13414 530564001365 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 530564001366 DNA-binding interface [nucleotide binding]; DNA binding site 530564001367 ParB-like nuclease domain; Region: ParBc; pfam02195 530564001368 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 530564001369 Walker A/P-loop; other site 530564001370 ATP binding site [chemical binding]; other site 530564001371 Q-loop/lid; other site 530564001372 ABC transporter signature motif; other site 530564001373 Walker B; other site 530564001374 D-loop; other site 530564001375 H-loop/switch region; other site 530564001376 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 530564001377 Coenzyme A binding pocket [chemical binding]; other site 530564001378 Terminase-like family; Region: Terminase_6; pfam03237 530564001379 Phage terminase large subunit; Region: Terminase_3; cl12054 530564001380 Phage-related terminase [General function prediction only]; Region: COG5362; cl02216 530564001381 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 530564001382 alanyl-tRNA synthetase; Provisional; Region: alaS; PRK13902 530564001383 PAS fold; Region: PAS; pfam00989 530564001384 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 530564001385 GAF domain; Region: GAF_2; pfam13185 530564001386 Response regulator receiver domain; Region: Response_reg; pfam00072 530564001387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564001388 active site 530564001389 phosphorylation site [posttranslational modification] 530564001390 intermolecular recognition site; other site 530564001391 dimerization interface [polypeptide binding]; other site 530564001392 phosphodiesterase YaeI; Provisional; Region: PRK11340 530564001393 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 530564001394 putative active site [active] 530564001395 putative metal binding site [ion binding]; other site 530564001396 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 530564001397 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 530564001398 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 530564001399 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; smart00941 530564001400 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 530564001401 Leucine-rich repeats; other site 530564001402 Substrate binding site [chemical binding]; other site 530564001403 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 530564001404 Cytokine receptor motif; other site 530564001405 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 530564001406 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 530564001407 active site 530564001408 metal binding site [ion binding]; metal-binding site 530564001409 Uncharacterized protein conserved in bacteria (DUF2200); Region: DUF2200; pfam09966 530564001410 Protein of unknown function (DUF1428); Region: DUF1428; cl02319 530564001411 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 530564001412 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 530564001413 catalytic residues [active] 530564001414 Predicted amidohydrolase [General function prediction only]; Region: COG0388 530564001415 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cd07197 530564001416 active site 530564001417 catalytic triad [active] 530564001418 dimer interface [polypeptide binding]; other site 530564001419 pyruvate phosphate dikinase; Provisional; Region: PRK09279 530564001420 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 530564001421 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 530564001422 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 530564001423 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 530564001424 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 530564001425 HEAT repeats; Region: HEAT_2; pfam13646 530564001426 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 530564001427 Di-haem cytochrome c peroxidase; Region: CCP_MauG; pfam03150 530564001428 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564001429 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 530564001430 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 530564001431 Peptidase propeptide and YPEB domain; Region: PepSY; pfam03413 530564001432 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564001433 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 530564001434 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 530564001435 NPCBM/NEW2 domain; Region: NPCBM; cl07060 530564001436 NPCBM/NEW2 domain; Region: NPCBM; cl07060 530564001437 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 530564001438 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 530564001439 Metal-binding active site; metal-binding site 530564001440 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 530564001441 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 530564001442 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 530564001443 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 530564001444 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 530564001445 active site 530564001446 catalytic residues [active] 530564001447 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 530564001448 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 530564001449 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 530564001450 Domain of unknown function (DUF1963); Region: DUF1963; pfam09234 530564001451 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 530564001452 formylmethanofuran--tetrahydromethanopterin formyltransferase; Provisional; Region: PRK02114 530564001453 Formylmethanofuran-tetrahydromethanopterin formyltransferase; Region: FTR; pfam01913 530564001454 FTR, proximal lobe; Region: FTR_C; pfam02741 530564001455 Circularly permuted YlqF-related GTPases; Region: YlqF_related_GTPase; cl17249 530564001456 GTP/Mg2+ binding site [chemical binding]; other site 530564001457 G5 box; other site 530564001458 GTPase SAR1 and related small G proteins [General function prediction only]; Region: COG1100 530564001459 trmE is a tRNA modification GTPase; Region: trmE; cd04164 530564001460 G1 box; other site 530564001461 G1 box; other site 530564001462 GTP/Mg2+ binding site [chemical binding]; other site 530564001463 Switch I region; other site 530564001464 Switch I region; other site 530564001465 G2 box; other site 530564001466 G2 box; other site 530564001467 Switch II region; other site 530564001468 G3 box; other site 530564001469 G4 box; other site 530564001470 G5 box; other site 530564001471 photolyase PhrII; Region: phr2; TIGR00591 530564001472 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 530564001473 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 530564001474 putative active site [active] 530564001475 substrate binding site [chemical binding]; other site 530564001476 putative cosubstrate binding site; other site 530564001477 catalytic site [active] 530564001478 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 530564001479 substrate binding site [chemical binding]; other site 530564001480 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 530564001481 active site 530564001482 catalytic residues [active] 530564001483 metal binding site [ion binding]; metal-binding site 530564001484 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 530564001485 PQQ-like domain; Region: PQQ_2; pfam13360 530564001486 Trp docking motif [polypeptide binding]; other site 530564001487 active site 530564001488 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 530564001489 Peptidase family M50; Region: Peptidase_M50; pfam02163 530564001490 active site 530564001491 putative substrate binding region [chemical binding]; other site 530564001492 Domain of unknown function DUF59; Region: DUF59; pfam01883 530564001493 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 530564001494 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 530564001495 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 530564001496 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 530564001497 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 530564001498 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 530564001499 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 530564001500 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 530564001501 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 530564001502 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 530564001503 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 530564001504 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 530564001505 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 530564001506 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 530564001507 NADH-quinone oxidoreductase, chain I; Region: NuoI; TIGR01971 530564001508 4Fe-4S binding domain; Region: Fer4; pfam00037 530564001509 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 530564001510 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 530564001511 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 530564001512 catalytic loop [active] 530564001513 iron binding site [ion binding]; other site 530564001514 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 530564001515 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 530564001516 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 530564001517 NADH:ubiquinone oxidoreductase, NADH-binding (51 kD) subunit [Energy production and conversion]; Region: NuoF; COG1894 530564001518 SLBB domain; Region: SLBB; pfam10531 530564001519 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; smart00928 530564001520 Respiratory-chain NADH dehydrogenase 24 Kd subunit; Region: Complex1_24kDa; pfam01257 530564001521 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 530564001522 [2Fe-2S] cluster binding site [ion binding]; other site 530564001523 putative dimer interface [polypeptide binding]; other site 530564001524 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 530564001525 NADH dehydrogenase subunit D; Validated; Region: PRK06075 530564001526 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 530564001527 NADH dehydrogenase subunit B; Validated; Region: PRK06411 530564001528 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 530564001529 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 530564001530 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 530564001531 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 530564001532 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 530564001533 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 530564001534 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 530564001535 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 530564001536 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 530564001537 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 530564001538 catalytic triad [active] 530564001539 Uncharacterized protein family (UPF0104); Region: UPF0104; pfam03706 530564001540 PQQ-like domain; Region: PQQ_2; pfam13360 530564001541 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 530564001542 Trp docking motif [polypeptide binding]; other site 530564001543 active site 530564001544 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 530564001545 Walker A/P-loop; other site 530564001546 ATP binding site [chemical binding]; other site 530564001547 DinB family; Region: DinB; cl17821 530564001548 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 530564001549 Part of AAA domain; Region: AAA_19; pfam13245 530564001550 Family description; Region: UvrD_C_2; pfam13538 530564001551 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 530564001552 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN_family; cd02803 530564001553 active site 530564001554 FMN binding site [chemical binding]; other site 530564001555 substrate binding site [chemical binding]; other site 530564001556 putative catalytic residue [active] 530564001557 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 530564001558 Sodium:dicarboxylate symporter family; Region: SDF; pfam00375 530564001559 Methane oxygenase PmoA; Region: PmoA; pfam14100 530564001560 6-phosphofructokinase; Provisional; Region: PRK03202 530564001561 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 530564001562 active site 530564001563 ADP/pyrophosphate binding site [chemical binding]; other site 530564001564 dimerization interface [polypeptide binding]; other site 530564001565 allosteric effector site; other site 530564001566 fructose-1,6-bisphosphate binding site; other site 530564001567 Uncharacterized conserved protein [Function unknown]; Region: COG3391 530564001568 tryptophan tryptophylquinone biosynthesis enzyme MauG; Region: TTQ_mauG; TIGR03791 530564001569 Cytochrome c; Region: Cytochrom_C; pfam00034 530564001570 Methyltransferase domain; Region: Methyltransf_26; pfam13659 530564001571 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 530564001572 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 530564001573 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 530564001574 FeS/SAM binding site; other site 530564001575 TRAM domain; Region: TRAM; pfam01938 530564001576 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 530564001577 tetramerization interface [polypeptide binding]; other site 530564001578 active site 530564001579 FRG domain; Region: FRG; pfam08867 530564001580 Glycerol-3-phosphate dehydrogenase [Energy production and conversion]; Region: GlpA; COG0578 530564001581 glycerol kinase; Provisional; Region: glpK; PRK00047 530564001582 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 530564001583 N- and C-terminal domain interface [polypeptide binding]; other site 530564001584 active site 530564001585 MgATP binding site [chemical binding]; other site 530564001586 catalytic site [active] 530564001587 metal binding site [ion binding]; metal-binding site 530564001588 glycerol binding site [chemical binding]; other site 530564001589 homotetramer interface [polypeptide binding]; other site 530564001590 homodimer interface [polypeptide binding]; other site 530564001591 FBP binding site [chemical binding]; other site 530564001592 protein IIAGlc interface [polypeptide binding]; other site 530564001593 Domain of unknown function (DUF2437); Region: DUF2437; pfam10370 530564001594 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, C-terminal subunit; Region: HpaG-C-term; TIGR02303 530564001595 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 530564001596 CoA binding domain; Region: CoA_binding_2; pfam13380 530564001597 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 530564001598 Radical SAM superfamily; Region: Radical_SAM; pfam04055 530564001599 FeS/SAM binding site; other site 530564001600 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 530564001601 Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712 530564001602 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 530564001603 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 530564001604 Methyltransferase domain; Region: Methyltransf_23; pfam13489 530564001605 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 530564001606 S-adenosylmethionine binding site [chemical binding]; other site 530564001607 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 530564001608 dimer interface [polypeptide binding]; other site 530564001609 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 530564001610 dimer interface [polypeptide binding]; other site 530564001611 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 530564001612 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 530564001613 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 530564001614 dimer interface [polypeptide binding]; other site 530564001615 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 530564001616 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 530564001617 Cysteine-rich CPXCG; Region: Cys_rich_CPXG; pfam14255 530564001618 fumarate hydratase; Reviewed; Region: fumC; PRK00485 530564001619 Class II fumarases; Region: Fumarase_classII; cd01362 530564001620 active site 530564001621 tetramer interface [polypeptide binding]; other site 530564001622 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564001623 TPR motif; other site 530564001624 binding surface 530564001625 TPR repeat; Region: TPR_11; pfam13414 530564001626 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564001627 binding surface 530564001628 TPR motif; other site 530564001629 TPR repeat; Region: TPR_11; pfam13414 530564001630 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564001631 binding surface 530564001632 TPR motif; other site 530564001633 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 530564001634 Cytochrome P450; Region: p450; pfam00067 530564001635 flavoprotein, HI0933 family; Region: TIGR00275 530564001636 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 530564001637 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 530564001638 active site 530564001639 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564001640 Domain of unknown function (DUF4147); Region: DUF4147; pfam13660 530564001641 MOFRL family; Region: MOFRL; pfam05161 530564001642 Major Facilitator Superfamily; Region: MFS_1; pfam07690 530564001643 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 530564001644 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 530564001645 PQQ-like domain; Region: PQQ_2; pfam13360 530564001646 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 530564001647 Trp docking motif [polypeptide binding]; other site 530564001648 active site 530564001649 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564001650 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564001651 Murein lipoprotein [Cell envelope biogenesis, outer membrane]; Region: COG4238; cl11539 530564001652 hypothetical protein; Provisional; Region: PRK00106 530564001653 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 530564001654 FOG: CBS domain [General function prediction only]; Region: COG0517 530564001655 2-oxoacid:acceptor oxidoreductase, alpha subunit; Region: OAFO_sf; TIGR03710 530564001656 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 530564001657 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 530564001658 dimer interface [polypeptide binding]; other site 530564001659 PYR/PP interface [polypeptide binding]; other site 530564001660 TPP binding site [chemical binding]; other site 530564001661 substrate binding site [chemical binding]; other site 530564001662 2-oxoglutarate ferredoxin oxidoreductase subunit beta; Reviewed; Region: PRK11867 530564001663 Thiamine pyrophosphate (TPP family), 2-oxoglutarate ferredoxin oxidoreductase (OGFOR) subfamily, TPP-binding module; OGFOR catalyzes the oxidative decarboxylation of 2-oxo-acids, with ferredoxin acting as an electron acceptor. In the TCA cycle, OGFOR...; Region: TPP_OGFOR; cd03375 530564001664 TPP-binding site [chemical binding]; other site 530564001665 FOG: CBS domain [General function prediction only]; Region: COG0517 530564001666 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 530564001667 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 530564001668 NAD(P) binding site [chemical binding]; other site 530564001669 active site 530564001670 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 530564001671 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 530564001672 putative active site [active] 530564001673 putative metal binding site [ion binding]; other site 530564001674 GAF domain; Region: GAF_3; pfam13492 530564001675 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 530564001676 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 530564001677 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 530564001678 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 530564001679 Walker A/P-loop; other site 530564001680 ATP binding site [chemical binding]; other site 530564001681 Q-loop/lid; other site 530564001682 ABC transporter signature motif; other site 530564001683 Walker B; other site 530564001684 D-loop; other site 530564001685 H-loop/switch region; other site 530564001686 ABC-2 family transporter protein; Region: ABC2_membrane_3; pfam12698 530564001687 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 530564001688 Response regulator containing a CheY-like receiver domain and an HD-GYP domain [Transcription / Signal transduction mechanisms]; Region: COG3437 530564001689 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564001690 active site 530564001691 phosphorylation site [posttranslational modification] 530564001692 intermolecular recognition site; other site 530564001693 dimerization interface [polypeptide binding]; other site 530564001694 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 530564001695 Zn2+ binding site [ion binding]; other site 530564001696 Mg2+ binding site [ion binding]; other site 530564001697 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 530564001698 PAS domain S-box; Region: sensory_box; TIGR00229 530564001699 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 530564001700 putative active site [active] 530564001701 heme pocket [chemical binding]; other site 530564001702 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 530564001703 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 530564001704 dimer interface [polypeptide binding]; other site 530564001705 phosphorylation site [posttranslational modification] 530564001706 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 530564001707 ATP binding site [chemical binding]; other site 530564001708 Mg2+ binding site [ion binding]; other site 530564001709 G-X-G motif; other site 530564001710 Response regulator receiver domain; Region: Response_reg; pfam00072 530564001711 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564001712 active site 530564001713 phosphorylation site [posttranslational modification] 530564001714 intermolecular recognition site; other site 530564001715 dimerization interface [polypeptide binding]; other site 530564001716 Response regulator receiver domain; Region: Response_reg; pfam00072 530564001717 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564001718 active site 530564001719 phosphorylation site [posttranslational modification] 530564001720 intermolecular recognition site; other site 530564001721 dimerization interface [polypeptide binding]; other site 530564001722 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 530564001723 putative binding surface; other site 530564001724 active site 530564001725 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 530564001726 active site 530564001727 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 530564001728 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 530564001729 active site 530564001730 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 530564001731 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 530564001732 tandem repeat interface [polypeptide binding]; other site 530564001733 oligomer interface [polypeptide binding]; other site 530564001734 active site residues [active] 530564001735 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 530564001736 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 530564001737 putative active site [active] 530564001738 putative metal binding site [ion binding]; other site 530564001739 Bacillus subtilis PhoD and related proteins, metallophosphatase domain; Region: MPP_PhoD; cd07389 530564001740 putative cation:proton antiport protein; Provisional; Region: PRK10669 530564001741 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 530564001742 TrkA-N domain; Region: TrkA_N; pfam02254 530564001743 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 530564001744 dimerization interface [polypeptide binding]; other site 530564001745 metal binding site [ion binding]; metal-binding site 530564001746 CsbD-like; Region: CsbD; cl17424 530564001747 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 530564001748 putative catalytic site [active] 530564001749 putative metal binding site [ion binding]; other site 530564001750 putative phosphate binding site [ion binding]; other site 530564001751 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; cl17752 530564001752 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 530564001753 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 530564001754 C-terminal binding protein (CtBP), D-isomer-specific 2-hydroxyacid dehydrogenases related repressor; Region: CtBP_dh; cd05299 530564001755 ligand binding site [chemical binding]; other site 530564001756 NAD binding site [chemical binding]; other site 530564001757 catalytic site [active] 530564001758 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564001759 ATP-dependent chaperone ClpB; Region: chaperone_ClpB; TIGR03346 530564001760 Clp amino terminal domain; Region: Clp_N; pfam02861 530564001761 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564001762 Walker A motif; other site 530564001763 ATP binding site [chemical binding]; other site 530564001764 Walker B motif; other site 530564001765 arginine finger; other site 530564001766 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564001767 Walker A motif; other site 530564001768 ATP binding site [chemical binding]; other site 530564001769 Walker B motif; other site 530564001770 arginine finger; other site 530564001771 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 530564001772 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 530564001773 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 530564001774 catalytic residues [active] 530564001775 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564001776 TPR repeat; Region: TPR_11; pfam13414 530564001777 TPR motif; other site 530564001778 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 530564001779 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 530564001780 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 530564001781 Nucleotide-binding domain of human HSPA9 and similar proteins; Region: HSPA9-Ssq1-like_NBD; cd10234 530564001782 nucleotide binding site [chemical binding]; other site 530564001783 NEF interaction site [polypeptide binding]; other site 530564001784 SBD interface [polypeptide binding]; other site 530564001785 Chorismate mutase type II; Region: CM_2; smart00830 530564001786 Prephenate dehydratase [Amino acid transport and metabolism]; Region: PheA; COG0077 530564001787 Prephenate dehydratase; Region: PDT; pfam00800 530564001788 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 530564001789 putative L-Phe binding site [chemical binding]; other site 530564001790 Uncharacterized conserved protein [Function unknown]; Region: COG0327 530564001791 NIF3 (NGG1p interacting factor 3); Region: NIF3; pfam01784 530564001792 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 530564001793 active site 530564001794 motif I; other site 530564001795 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 530564001796 motif II; other site 530564001797 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 530564001798 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 530564001799 putative active site [active] 530564001800 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 530564001801 LITAF-like zinc ribbon domain; Region: zf-LITAF-like; cl02754 530564001802 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 530564001803 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 530564001804 intersubunit interface [polypeptide binding]; other site 530564001805 active site 530564001806 zinc binding site [ion binding]; other site 530564001807 Na+ binding site [ion binding]; other site 530564001808 The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the...; Region: Membrane-FADS-like; cl00615 530564001809 Fatty acid desaturase; Region: FA_desaturase; pfam00487 530564001810 putative di-iron ligands [ion binding]; other site 530564001811 NADPH:quinone reductase and related Zn-dependent oxidoreductases [Energy production and conversion / General function prediction only]; Region: Qor; COG0604 530564001812 Zeta-crystallin with NADP-dependent quinone reductase activity (QOR); Region: zeta_crystallin; cd08253 530564001813 NAD(P) binding site [chemical binding]; other site 530564001814 Protein of unknown function (DUF1611); Region: DUF1611; pfam07755 530564001815 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 530564001816 Protein of unknown function (DUF3467); Region: DUF3467; pfam11950 530564001817 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 530564001818 active site 530564001819 putative substrate binding region [chemical binding]; other site 530564001820 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 530564001821 HlyD family secretion protein; Region: HlyD_3; pfam13437 530564001822 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 530564001823 GAF domain; Region: GAF; pfam01590 530564001824 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 530564001825 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 530564001826 preprotein translocase subunit SecA; Reviewed; Region: secA; PRK12898 530564001827 SecA preprotein cross-linking domain; Region: SecA_PP_bind; cl03078 530564001828 nucleotide binding region [chemical binding]; other site 530564001829 Helicase conserved C-terminal domain; Region: Helicase_C; pfam00271 530564001830 ATP-binding site [chemical binding]; other site 530564001831 Protein of unknown function (DUF1551); Region: DUF1551; pfam07585 530564001832 Uncharacterized conserved protein (DUF2048); Region: DUF2048; pfam09752 530564001833 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 530564001834 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564001835 Succinate:quinone oxidoreductase (SQR) Type B subfamily 1, transmembrane subunit; composed of proteins similar to Bacillus subtilis SQR. SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. Bacillus subtilis...; Region: SQR_TypeB_1_TM; cd03497 530564001836 putative Iron-sulfur protein interface [polypeptide binding]; other site 530564001837 proximal heme binding site [chemical binding]; other site 530564001838 distal heme binding site [chemical binding]; other site 530564001839 putative dimer interface [polypeptide binding]; other site 530564001840 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08641 530564001841 L-aspartate oxidase; Provisional; Region: PRK06175 530564001842 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 530564001843 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK08640 530564001844 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 530564001845 HEAT repeats; Region: HEAT_2; pfam13646 530564001846 Domain of unknown function (DUF4375); Region: DUF4375; pfam14300 530564001847 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 530564001848 Proline dehydrogenase; Region: Pro_dh; cl03282 530564001849 Delta(1)-pyrroline-5-carboxylate dehydrogenase, RocA; Region: ALDH_PutA-P5CDH-RocA; cd07124 530564001850 1-pyrroline-5-carboxylate dehydrogenase; Provisional; Region: PRK03137 530564001851 Glutamate binding site [chemical binding]; other site 530564001852 homodimer interface [polypeptide binding]; other site 530564001853 NAD binding site [chemical binding]; other site 530564001854 catalytic residues [active] 530564001855 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 530564001856 PQQ-like domain; Region: PQQ_2; pfam13360 530564001857 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 530564001858 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 530564001859 catalytic residues [active] 530564001860 dimer interface [polypeptide binding]; other site 530564001861 Ribosomal protein L24e/L24 is a ribosomal protein found in eukaryotes (L24) and in archaea (L24e, distinct from archaeal L24). L24e/L24 is located on the surface of the large subunit, adjacent to proteins L14 and L3, and near the translation factor...; Region: Ribosomal_L24e_L24; cl00909 530564001862 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cl01482 530564001863 squalene-associated FAD-dependent desaturase; Region: HpnE; TIGR03467 530564001864 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 530564001865 active site lid residues [active] 530564001866 substrate binding pocket [chemical binding]; other site 530564001867 catalytic residues [active] 530564001868 substrate-Mg2+ binding site; other site 530564001869 aspartate-rich region 1; other site 530564001870 aspartate-rich region 2; other site 530564001871 Trans-Isoprenyl Diphosphate Synthases, head-to-head; Region: Trans_IPPS_HH; cd00683 530564001872 active site lid residues [active] 530564001873 substrate binding pocket [chemical binding]; other site 530564001874 catalytic residues [active] 530564001875 substrate-Mg2+ binding site; other site 530564001876 aspartate-rich region 1; other site 530564001877 aspartate-rich region 2; other site 530564001878 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 530564001879 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 530564001880 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 530564001881 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 530564001882 Beta-Casp domain; Region: Beta-Casp; smart01027 530564001883 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 530564001884 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 530564001885 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 530564001886 catalytic residues [active] 530564001887 Protein of unknown function (DUF4231); Region: DUF4231; pfam14015 530564001888 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 530564001889 Inorganic H+ pyrophosphatase; Region: H_PPase; pfam03030 530564001890 H(+) -translocating inorganic pyrophosphatase; Region: PLN02255; cl11452 530564001891 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 530564001892 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 530564001893 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 530564001894 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 530564001895 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 530564001896 Sulfatase; Region: Sulfatase; pfam00884 530564001897 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 530564001898 active site 530564001899 catalytic triad [active] 530564001900 oxyanion hole [active] 530564001901 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 530564001902 HEAT repeats; Region: HEAT_2; pfam13646 530564001903 HEAT repeats; Region: HEAT_2; pfam13646 530564001904 HEAT repeats; Region: HEAT_2; pfam13646 530564001905 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 530564001906 Cytochrome c; Region: Cytochrom_C; pfam00034 530564001907 Protein of unknown function (DUF1566); Region: DUF1566; pfam07603 530564001908 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07666 530564001909 classical (c) SDRs; Region: SDR_c; cd05233 530564001910 NAD(P) binding site [chemical binding]; other site 530564001911 active site 530564001912 RDD family; Region: RDD; pfam06271 530564001913 Integral membrane protein DUF95; Region: DUF95; pfam01944 530564001914 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 530564001915 Domain of unknown function (DUF4350); Region: DUF4350; pfam14258 530564001916 MoxR-like ATPases [General function prediction only]; Region: COG0714 530564001917 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564001918 Walker A motif; other site 530564001919 ATP binding site [chemical binding]; other site 530564001920 Walker B motif; other site 530564001921 arginine finger; other site 530564001922 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 530564001923 Protein of unknown function DUF58; Region: DUF58; pfam01882 530564001924 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 530564001925 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 530564001926 RNA binding surface [nucleotide binding]; other site 530564001927 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 530564001928 active site 530564001929 Highly conserved protein containing a thioredoxin domain [Posttranslational modification, protein turnover, chaperones]; Region: COG1331 530564001930 TRX domain, SSP411 protein family; members of this family are highly conserved proteins present in eukaryotes, bacteria and archaea, about 600-800 amino acids in length, which contain a TRX domain with a redox active CXXC motif. The human/rat protein; Region: SSP411; cd02955 530564001931 catalytic residues [active] 530564001932 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 530564001933 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 530564001934 NAD(P) binding site [chemical binding]; other site 530564001935 short chain dehydrogenase; Provisional; Region: PRK06181 530564001936 active site 530564001937 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 530564001938 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 530564001939 metal binding site [ion binding]; metal-binding site 530564001940 active site 530564001941 I-site; other site 530564001942 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 530564001943 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 530564001944 metal binding site [ion binding]; metal-binding site 530564001945 active site 530564001946 I-site; other site 530564001947 Protein of unknown function (DUF935); Region: DUF935; pfam06074 530564001948 Protein of unknown function (DUF1320); Region: DUF1320; cl01818 530564001949 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 530564001950 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 530564001951 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 530564001952 putative menaquinone biosynthesis protein, SCO4494 family; Region: mena_SCO4494; TIGR03700 530564001953 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 530564001954 FeS/SAM binding site; other site 530564001955 Lipoprotein signal peptidase [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: LspA; COG0597 530564001956 lipoprotein signal peptidase; Provisional; Region: PRK14787 530564001957 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 530564001958 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 530564001959 Low molecular weight phosphatase family; Region: LMWPc; cl00105 530564001960 active site 530564001961 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 530564001962 HEAT repeats; Region: HEAT_2; pfam13646 530564001963 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 530564001964 Cytochrome c; Region: Cytochrom_C; pfam00034 530564001965 Integral membrane protein (PIN domain superfamily) [General function prediction only]; Region: COG4956 530564001966 PIN domain of Thermus Thermophilus Hb8, uncharacterized Bacillus subtilis YacL, and other bacterial homologs; Region: PIN_YacL; cd09877 530564001967 putative active site [active] 530564001968 deoxyguanosinetriphosphate triphosphohydrolase-like protein; Provisional; Region: PRK01286 530564001969 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 530564001970 Zn2+ binding site [ion binding]; other site 530564001971 Mg2+ binding site [ion binding]; other site 530564001972 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 530564001973 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 530564001974 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 530564001975 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 530564001976 Walker A/P-loop; other site 530564001977 ATP binding site [chemical binding]; other site 530564001978 Q-loop/lid; other site 530564001979 ABC transporter signature motif; other site 530564001980 Walker B; other site 530564001981 D-loop; other site 530564001982 H-loop/switch region; other site 530564001983 Response regulator receiver domain; Region: Response_reg; pfam00072 530564001984 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564001985 active site 530564001986 phosphorylation site [posttranslational modification] 530564001987 intermolecular recognition site; other site 530564001988 dimerization interface [polypeptide binding]; other site 530564001989 Ycf48-like protein; Provisional; Region: PRK13684 530564001990 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 530564001991 Asp-box motif; other site 530564001992 Tetratricopeptide repeat; Region: TPR_6; pfam13174 530564001993 DOMON-like type 9 carbohydrate binding module; Region: CBM9_like_2; cd09618 530564001994 putative ligand binding site [chemical binding]; other site 530564001995 Sec-independent protein secretion pathway components [Intracellular trafficking and secretion]; Region: TatA; COG1826 530564001996 mttA/Hcf106 family; Region: MttA_Hcf106; cl00788 530564001997 ScpA/B protein; Region: ScpA_ScpB; cl00598 530564001998 Transposase IS200 like; Region: Y1_Tnp; cl00848 530564001999 Predicted metal-dependent hydrolase of the TIM-barrel fold [General function prediction only]; Region: COG3618 530564002000 Amidohydrolase; Region: Amidohydro_2; pfam04909 530564002001 active site 530564002002 RbsD / FucU transport protein family; Region: RbsD_FucU; pfam05025 530564002003 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 530564002004 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 530564002005 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 530564002006 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 530564002007 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 530564002008 putative NAD(P) binding site [chemical binding]; other site 530564002009 catalytic Zn binding site [ion binding]; other site 530564002010 structural Zn binding site [ion binding]; other site 530564002011 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 530564002012 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 530564002013 active site 530564002014 catalytic tetrad [active] 530564002015 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 530564002016 putative dimerization interface [polypeptide binding]; other site 530564002017 Transcriptional regulators [Transcription]; Region: PurR; COG1609 530564002018 putative ligand binding site [chemical binding]; other site 530564002019 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 530564002020 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 530564002021 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 530564002022 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 530564002023 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 530564002024 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 530564002025 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 530564002026 oligomerisation interface [polypeptide binding]; other site 530564002027 mobile loop; other site 530564002028 roof hairpin; other site 530564002029 phosphodiesterase; Provisional; Region: PRK12704 530564002030 hypothetical protein; Provisional; Region: PRK05409 530564002031 Uncharacterized protein conserved in bacteria (DUF2063); Region: DUF2063; pfam09836 530564002032 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 530564002033 rRNA interaction site [nucleotide binding]; other site 530564002034 S8 interaction site; other site 530564002035 putative laminin-1 binding site; other site 530564002036 elongation factor Ts; Provisional; Region: tsf; PRK09377 530564002037 UBA/TS-N domain; Region: UBA; pfam00627 530564002038 Elongation factor TS; Region: EF_TS; pfam00889 530564002039 Elongation factor TS; Region: EF_TS; pfam00889 530564002040 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 530564002041 putative nucleotide binding site [chemical binding]; other site 530564002042 uridine monophosphate binding site [chemical binding]; other site 530564002043 homohexameric interface [polypeptide binding]; other site 530564002044 ribosome recycling factor; Reviewed; Region: frr; PRK00083 530564002045 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 530564002046 hinge region; other site 530564002047 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 530564002048 Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily; Region: PI-PLCc_GDPD_SF; cl14615 530564002049 active site 530564002050 catalytic site [active] 530564002051 DNA topoisomerase VI subunit A; Provisional; Region: PRK04342 530564002052 Type IIB DNA topoisomerase; Region: TP6A_N; pfam04406 530564002053 TOPRIM_TopoIIB_SPO: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in the type IIB family of DNA topoisomerases and Spo11. This subgroup contains proteins similar to Sulfolobus shibatae topoisomerase VI (TopoVI)...; Region: TOPRIM_TopoIIB_SPO; cd00223 530564002054 active site 530564002055 metal binding site [ion binding]; metal-binding site 530564002056 interdomain interaction site; other site 530564002057 DNA topoisomerase VI subunit B; Validated; Region: PRK04184 530564002058 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 530564002059 ATP binding site [chemical binding]; other site 530564002060 Mg2+ binding site [ion binding]; other site 530564002061 G-X-G motif; other site 530564002062 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 530564002063 MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second...; Region: TopoII_MutL_Trans; cl02783 530564002064 ATP binding site [chemical binding]; other site 530564002065 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 530564002066 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 530564002067 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 530564002068 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 530564002069 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 530564002070 metal ion-dependent adhesion site (MIDAS); other site 530564002071 Members of the SGNH-hydrolase superfamily, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase_like_7; cd04502 530564002072 active site 530564002073 catalytic triad [active] 530564002074 oxyanion hole [active] 530564002075 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 530564002076 FAD binding pocket [chemical binding]; other site 530564002077 conserved FAD binding motif [chemical binding]; other site 530564002078 phosphate binding motif [ion binding]; other site 530564002079 beta-alpha-beta structure motif; other site 530564002080 NAD binding pocket [chemical binding]; other site 530564002081 GTP-binding protein YchF; Reviewed; Region: PRK09601 530564002082 YchF GTPase; Region: YchF; cd01900 530564002083 G1 box; other site 530564002084 GTP/Mg2+ binding site [chemical binding]; other site 530564002085 Switch I region; other site 530564002086 G2 box; other site 530564002087 Switch II region; other site 530564002088 G3 box; other site 530564002089 G4 box; other site 530564002090 G5 box; other site 530564002091 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 530564002092 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 530564002093 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 530564002094 active site 530564002095 catalytic tetrad [active] 530564002096 Choline dehydrogenase and related flavoproteins [Amino acid transport and metabolism]; Region: BetA; COG2303 530564002097 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 530564002098 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 530564002099 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 530564002100 binding surface 530564002101 TPR motif; other site 530564002102 FOG: CBS domain [General function prediction only]; Region: COG0517 530564002103 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 530564002104 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 530564002105 isocitrate dehydrogenase; Validated; Region: PRK06451 530564002106 Tetraacyldisaccharide-1-P 4'-kinase; Region: LpxK; pfam02606 530564002107 Tetraacyldisaccharide-1-P 4'-kinase [Cell envelope biogenesis, outer membrane]; Region: LpxK; COG1663 530564002108 BON domain; Region: BON; cl02771 530564002109 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 530564002110 ligand-binding site [chemical binding]; other site 530564002111 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 530564002112 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 530564002113 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_1; cd09606 530564002114 oligoendopeptidase, M3 family; Region: M3_not_pepF; TIGR02289 530564002115 active site 530564002116 Zn binding site [ion binding]; other site 530564002117 Protein of unknown function (DUF1614); Region: DUF1614; pfam07758 530564002118 Predicted metal-dependent hydrolase with the TIM-barrel fold [General function prediction only]; Region: COG1574 530564002119 YtcJ_like metal dependent amidohydrolases. YtcJ is a Bacillus subtilis ORF of unknown function. The Arabidopsis homolog LAF3 has been identified as a factor required for photochrome A signalling; Region: YtcJ_like; cd01300 530564002120 active site 530564002121 Isochorismatase family; Region: Isochorismatase; pfam00857 530564002122 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 530564002123 catalytic triad [active] 530564002124 dimer interface [polypeptide binding]; other site 530564002125 conserved cis-peptide bond; other site 530564002126 hopanoid-associated sugar epimerase; Region: HpnA; TIGR03466 530564002127 uncharacterized subgroup of aldehyde reductase and flavonoid reductase related proteins, extended (e) SDRs; Region: AR_FR_like_1_SDR_e; cd05228 530564002128 putative NADP binding site [chemical binding]; other site 530564002129 putative substrate binding site [chemical binding]; other site 530564002130 active site 530564002131 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK08217 530564002132 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 530564002133 NAD(P) binding site [chemical binding]; other site 530564002134 active site 530564002135 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 530564002136 active site 530564002137 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 530564002138 active site 530564002139 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 530564002140 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 530564002141 S-adenosylmethionine binding site [chemical binding]; other site 530564002142 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 530564002143 active site 530564002144 dimer interface [polypeptide binding]; other site 530564002145 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 530564002146 HlyD family secretion protein; Region: HlyD_3; pfam13437 530564002147 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 530564002148 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 530564002149 Walker A/P-loop; other site 530564002150 ATP binding site [chemical binding]; other site 530564002151 Q-loop/lid; other site 530564002152 ABC transporter signature motif; other site 530564002153 Walker B; other site 530564002154 D-loop; other site 530564002155 H-loop/switch region; other site 530564002156 DevC protein; Region: devC; TIGR01185 530564002157 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 530564002158 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 530564002159 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 530564002160 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 530564002161 phosphonoacetate hydrolase; Region: hydr_PhnA; TIGR02335 530564002162 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 530564002163 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 530564002164 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 530564002165 Beta-lactamase; Region: Beta-lactamase; pfam00144 530564002166 Nucleotidyltransferase (NT) domain of family X DNA Polymerases; Region: NT_POLXc; cd00141 530564002167 hypothetical protein; Provisional; Region: PRK08609 530564002168 active site 530564002169 primer binding site [nucleotide binding]; other site 530564002170 NTP binding site [chemical binding]; other site 530564002171 metal binding triad [ion binding]; metal-binding site 530564002172 Polymerase and Histidinol Phosphatase domain of bacterial polymerase X; Region: PHP_PolX; cd07436 530564002173 active site 530564002174 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 530564002175 G1 box; other site 530564002176 GTP/Mg2+ binding site [chemical binding]; other site 530564002177 G2 box; other site 530564002178 Switch I region; other site 530564002179 G3 box; other site 530564002180 Switch II region; other site 530564002181 G4 box; other site 530564002182 G5 box; other site 530564002183 The TGS domain, named after the ThrRS, GTPase, and SpoT/RelA proteins where it occurs, is structurally similar to ubiquitin. TGS is a small domain of about 50 amino acid residues with a predominantly beta-sheet structure. There is no direct information...; Region: TGS; cl15768 530564002184 von Hippel-Landau (pVHL) tumor suppressor protein; Region: pVHL; cd05468 530564002185 pVHL-HIF-1alpha interaction [polypeptide binding]; other site 530564002186 pVHL-ElonginB-ElonginC (VBC) interface [polypeptide binding]; other site 530564002187 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 530564002188 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 530564002189 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, YBL036c-like proteins; Region: PLPDE_III_YBL036c_like; cd00635 530564002190 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 530564002191 catalytic residue [active] 530564002192 Uncharacterized ACR, YggU family COG1872; Region: DUF167; cl00811 530564002193 Methane oxygenase PmoA; Region: PmoA; pfam14100 530564002194 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 530564002195 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 530564002196 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 530564002197 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564002198 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564002199 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 530564002200 putative catalytic site [active] 530564002201 putative metal binding site [ion binding]; other site 530564002202 putative phosphate binding site [ion binding]; other site 530564002203 Fe2+/Zn2+ uptake regulation proteins [Inorganic ion transport and metabolism]; Region: Fur; COG0735 530564002204 metal binding site 2 [ion binding]; metal-binding site 530564002205 putative DNA binding helix; other site 530564002206 metal binding site 1 [ion binding]; metal-binding site 530564002207 dimer interface [polypeptide binding]; other site 530564002208 structural Zn2+ binding site [ion binding]; other site 530564002209 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 530564002210 dimerization interface [polypeptide binding]; other site 530564002211 putative DNA binding site [nucleotide binding]; other site 530564002212 putative Zn2+ binding site [ion binding]; other site 530564002213 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 530564002214 Na+/H+ antiporter NhaD and related arsenite permeases [Inorganic ion transport and metabolism]; Region: ArsB; COG1055 530564002215 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 530564002216 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 530564002217 catalytic residues [active] 530564002218 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 530564002219 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 530564002220 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 530564002221 Ligand Binding Site [chemical binding]; other site 530564002222 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 530564002223 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 530564002224 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 530564002225 catalytic residue [active] 530564002226 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564002227 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 530564002228 Walker A motif; other site 530564002229 ATP binding site [chemical binding]; other site 530564002230 Walker B motif; other site 530564002231 arginine finger; other site 530564002232 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 530564002233 DnaA box-binding interface [nucleotide binding]; other site 530564002234 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 530564002235 DNA polymerase III subunit beta; Validated; Region: PRK05643 530564002236 putative DNA binding surface [nucleotide binding]; other site 530564002237 dimer interface [polypeptide binding]; other site 530564002238 beta-clamp/clamp loader binding surface; other site 530564002239 beta-clamp/translesion DNA polymerase binding surface; other site 530564002240 Protein of unknown function (DUF721); Region: DUF721; pfam05258 530564002241 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 530564002242 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 530564002243 ATP binding site [chemical binding]; other site 530564002244 Mg2+ binding site [ion binding]; other site 530564002245 G-X-G motif; other site 530564002246 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 530564002247 anchoring element; other site 530564002248 dimer interface [polypeptide binding]; other site 530564002249 ATP binding site [chemical binding]; other site 530564002250 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 530564002251 active site 530564002252 metal binding site [ion binding]; metal-binding site 530564002253 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 530564002254 Predicted esterase [General function prediction only]; Region: COG0400 530564002255 Serine hydrolase (FSH1); Region: FSH1; pfam03959 530564002256 Domain of unknown function (DUF2088); Region: DUF2088; cl15406 530564002257 multifunctional aminopeptidase A; Provisional; Region: PRK00913 530564002258 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 530564002259 interface (dimer of trimers) [polypeptide binding]; other site 530564002260 Substrate-binding/catalytic site; other site 530564002261 Zn-binding sites [ion binding]; other site 530564002262 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Region: UbiD; pfam01977 530564002263 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 530564002264 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 530564002265 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 530564002266 pteridine reductase; Provisional; Region: PRK09135 530564002267 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 530564002268 NAD(P) binding site [chemical binding]; other site 530564002269 active site 530564002270 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 530564002271 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 530564002272 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 530564002273 HlyD family secretion protein; Region: HlyD_3; pfam13437 530564002274 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 530564002275 Protein export membrane protein; Region: SecD_SecF; cl14618 530564002276 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 530564002277 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 530564002278 motif II; other site 530564002279 Transposase IS200 like; Region: Y1_Tnp; cl00848 530564002280 prephenate dehydrogenase; Validated; Region: PRK08507 530564002281 Prephenate dehydrogenase; Region: PDH; pfam02153 530564002282 Phosphoribosylformylglycinamidine (FGAM) synthase; Region: PurS; cl00789 530564002283 Phosphoribosylformylglycinamidine (FGAM) synthase, synthetase domain [Nucleotide transport and metabolism]; Region: PurL; COG0046 530564002284 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 530564002285 dimerization interface [polypeptide binding]; other site 530564002286 ATP binding site [chemical binding]; other site 530564002287 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), second repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat2; cd02204 530564002288 dimerization interface [polypeptide binding]; other site 530564002289 ATP binding site [chemical binding]; other site 530564002290 CobB/CobQ-like glutamine amidotransferase domain; Region: GATase_5; pfam13507 530564002291 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 530564002292 putative active site [active] 530564002293 catalytic triad [active] 530564002294 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564002295 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 530564002296 active site 530564002297 dimer interface [polypeptide binding]; other site 530564002298 metal binding site [ion binding]; metal-binding site 530564002299 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 530564002300 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 530564002301 Oligomerisation domain; Region: Oligomerisation; pfam02410 530564002302 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 530564002303 DNA protecting protein DprA; Region: dprA; TIGR00732 530564002304 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 530564002305 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564002306 active site 530564002307 phosphorylation site [posttranslational modification] 530564002308 intermolecular recognition site; other site 530564002309 dimerization interface [polypeptide binding]; other site 530564002310 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 530564002311 DNA binding residues [nucleotide binding] 530564002312 dimerization interface [polypeptide binding]; other site 530564002313 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 530564002314 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 530564002315 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 530564002316 catalytic residue [active] 530564002317 FOG: WD40 repeat [General function prediction only]; Region: COG2319 530564002318 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 530564002319 structural tetrad; other site 530564002320 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 530564002321 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 530564002322 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 530564002323 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 530564002324 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 530564002325 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 530564002326 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 530564002327 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 530564002328 ATP binding site [chemical binding]; other site 530564002329 Walker A motif; other site 530564002330 hexamer interface [polypeptide binding]; other site 530564002331 Walker B motif; other site 530564002332 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 530564002333 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 530564002334 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 530564002335 Flp/Fap pilin component; Region: Flp_Fap; cl01585 530564002336 Flp/Fap pilin component; Region: Flp_Fap; cl01585 530564002337 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 530564002338 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564002339 Walker A motif; other site 530564002340 ATP binding site [chemical binding]; other site 530564002341 Walker B motif; other site 530564002342 arginine finger; other site 530564002343 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 530564002344 DNA translocase FtsK; Provisional; Region: PRK10263 530564002345 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 530564002346 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 530564002347 dimer interface [polypeptide binding]; other site 530564002348 phosphorylation site [posttranslational modification] 530564002349 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 530564002350 ATP binding site [chemical binding]; other site 530564002351 Mg2+ binding site [ion binding]; other site 530564002352 G-X-G motif; other site 530564002353 Helix-turn-helix domain; Region: HTH_17; pfam12728 530564002354 Response regulator receiver domain; Region: Response_reg; pfam00072 530564002355 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564002356 active site 530564002357 phosphorylation site [posttranslational modification] 530564002358 intermolecular recognition site; other site 530564002359 dimerization interface [polypeptide binding]; other site 530564002360 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 530564002361 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 530564002362 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 530564002363 Sulfatase; Region: Sulfatase; cl17466 530564002364 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 530564002365 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 530564002366 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 530564002367 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 530564002368 The HIRAN protein (HIP116, Rad5p N-terminal) is found in the N-terminal regions of the SWI2/SNF2 proteins typified by HIP116 and Rad5p; Region: HIRAN; smart00910 530564002369 A new structural DNA glycosylase; Region: AlkD_like; cd06561 530564002370 active site 530564002371 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 530564002372 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 530564002373 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 530564002374 putative dimerization interface [polypeptide binding]; other site 530564002375 Transcription elongation factor Elf1 like; Region: Elf1; cl02038 530564002376 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 530564002377 Catalytic domain of Protein Kinases; Region: PKc; cd00180 530564002378 active site 530564002379 ATP binding site [chemical binding]; other site 530564002380 substrate binding site [chemical binding]; other site 530564002381 activation loop (A-loop); other site 530564002382 TIR domain; Region: TIR_2; cl17458 530564002383 NACHT domain; Region: NACHT; pfam05729 530564002384 ferredoxin-type protein, NapH/MauN family; Region: napH_; TIGR02163 530564002385 4Fe-4S binding domain; Region: Fer4_5; pfam12801 530564002386 4Fe-4S binding domain; Region: Fer4_5; pfam12801 530564002387 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 530564002388 4Fe-4S binding domain; Region: Fer4; pfam00037 530564002389 4Fe-4S binding domain; Region: Fer4; pfam00037 530564002390 4Fe-4S dicluster domain; Region: Fer4_9; pfam13187 530564002391 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564002392 binding surface 530564002393 TPR motif; other site 530564002394 FMN-binding domain; Region: FMN_bind; cl01081 530564002395 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 530564002396 ApbE family; Region: ApbE; pfam02424 530564002397 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 530564002398 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 530564002399 chromosome segregation protein SMC, primarily archaeal type; Region: SMC_prok_A; TIGR02169 530564002400 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 530564002401 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 530564002402 alpha-glucan phosphorylases; Region: more_P_ylases; TIGR02094 530564002403 FxsA cytoplasmic membrane protein; Region: FxsA; pfam04186 530564002404 Lactonase, 7-bladed beta-propeller; Region: Lactonase; pfam10282 530564002405 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 530564002406 Helix-turn-helix domain; Region: HTH_17; pfam12728 530564002407 GIY-YIG domain of uncharacterized hypothetical protein found in bacteria and archaea; Region: GIY-YIG_unchar_2; cd10447 530564002408 GIY-YIG motif/motif A; other site 530564002409 putative active site [active] 530564002410 putative metal binding site [ion binding]; other site 530564002411 Domain of unknown function (DUF4357); Region: DUF4357; pfam14267 530564002412 HsdM N-terminal domain; Region: HsdM_N; pfam12161 530564002413 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 530564002414 Methyltransferase domain; Region: Methyltransf_26; pfam13659 530564002415 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 530564002416 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 530564002417 type I site-specific deoxyribonuclease, HsdR family; Region: hsdR; TIGR00348 530564002418 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 530564002419 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 530564002420 ATP binding site [chemical binding]; other site 530564002421 putative Mg++ binding site [ion binding]; other site 530564002422 Protein of unknown function DUF45; Region: DUF45; pfam01863 530564002423 CRISPR/Cas system-associated RAMP superfamily protein Cas6; Region: Cas6-I-III; cl11443 530564002424 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 530564002425 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 530564002426 putative active site [active] 530564002427 putative NTP binding site [chemical binding]; other site 530564002428 putative nucleic acid binding site [nucleotide binding]; other site 530564002429 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-II-III; cd09634 530564002430 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I_II_III; cd09725 530564002431 Predicted CRISPR-associated polymerase [Defense mechanisms]; Region: COG1353 530564002432 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 530564002433 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 530564002434 CRISPR/Cas system-associated RAMP superfamily protein; Region: RAMP_I_III; cd09726 530564002435 CRISPR-associated protein; Region: TIGR03986 530564002436 Helix-turn-helix domain; Region: HTH_17; cl17695 530564002437 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 530564002438 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 530564002439 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 530564002440 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 530564002441 IEV and EEV membrane glycoprotein; Provisional; Region: PHA02953; cl17631 530564002442 FOG: WD40 repeat [General function prediction only]; Region: COG2319 530564002443 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 530564002444 structural tetrad; other site 530564002445 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 530564002446 Sulfatase; Region: Sulfatase; pfam00884 530564002447 RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989 530564002448 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 530564002449 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 530564002450 DNA binding residues [nucleotide binding] 530564002451 FecR protein; Region: FecR; pfam04773 530564002452 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 530564002453 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 530564002454 Sulfatase; Region: Sulfatase; pfam00884 530564002455 Domain of unknown function (DUF303); Region: DUF303; pfam03629 530564002456 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 530564002457 Sulfatase; Region: Sulfatase; cl17466 530564002458 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 530564002459 Sulfatase; Region: Sulfatase; cl17466 530564002460 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 530564002461 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 530564002462 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 530564002463 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 530564002464 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 530564002465 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 530564002466 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 530564002467 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 530564002468 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; cl14105 530564002469 Homocysteine S-methyltransferase; Region: S-methyl_trans; pfam02574 530564002470 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 530564002471 protein binding site [polypeptide binding]; other site 530564002472 Domain of unknown function (DUF303); Region: DUF303; pfam03629 530564002473 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 530564002474 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 530564002475 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 530564002476 DNA binding residues [nucleotide binding] 530564002477 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 530564002478 Fasciclin domain; Region: Fasciclin; pfam02469 530564002479 Uncharacterized conserved protein [Function unknown]; Region: COG1262 530564002480 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 530564002481 Uncharacterized conserved protein [Function unknown]; Region: COG1262 530564002482 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 530564002483 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564002484 TPR motif; other site 530564002485 Tetratricopeptide repeat; Region: TPR_16; pfam13432 530564002486 binding surface 530564002487 Tetratricopeptide repeat; Region: TPR_16; pfam13432 530564002488 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564002489 binding surface 530564002490 TPR motif; other site 530564002491 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 530564002492 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 530564002493 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 530564002494 Uncharacterized ACR, COG1430; Region: DUF192; pfam02643 530564002495 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 530564002496 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 530564002497 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 530564002498 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 530564002499 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 530564002500 ATP binding site [chemical binding]; other site 530564002501 Walker A motif; other site 530564002502 hexamer interface [polypeptide binding]; other site 530564002503 Walker B motif; other site 530564002504 AAA domain; Region: AAA_31; pfam13614 530564002505 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 530564002506 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 530564002507 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 530564002508 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 530564002509 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 530564002510 TadE-like protein; Region: TadE; pfam07811 530564002511 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 530564002512 Class III signal peptide; Region: Class_IIIsignal; pfam04021 530564002513 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 530564002514 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564002515 active site 530564002516 phosphorylation site [posttranslational modification] 530564002517 intermolecular recognition site; other site 530564002518 dimerization interface [polypeptide binding]; other site 530564002519 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 530564002520 DNA binding residues [nucleotide binding] 530564002521 dimerization interface [polypeptide binding]; other site 530564002522 CheB methylesterase; Region: CheB_methylest; pfam01339 530564002523 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 530564002524 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 530564002525 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 530564002526 S-adenosylmethionine binding site [chemical binding]; other site 530564002527 TATA element modulatory factor 1 TATA binding; Region: TMF_TATA_bd; pfam12325 530564002528 PAS domain; Region: PAS_10; pfam13596 530564002529 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 530564002530 putative active site [active] 530564002531 heme pocket [chemical binding]; other site 530564002532 PAS domain; Region: PAS_9; pfam13426 530564002533 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 530564002534 putative active site [active] 530564002535 heme pocket [chemical binding]; other site 530564002536 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: COG4585 530564002537 Histidine kinase; Region: HisKA_3; pfam07730 530564002538 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 530564002539 ATP binding site [chemical binding]; other site 530564002540 Mg2+ binding site [ion binding]; other site 530564002541 G-X-G motif; other site 530564002542 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564002543 Response regulator receiver domain; Region: Response_reg; pfam00072 530564002544 active site 530564002545 phosphorylation site [posttranslational modification] 530564002546 intermolecular recognition site; other site 530564002547 dimerization interface [polypeptide binding]; other site 530564002548 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 530564002549 Proteolipid membrane potential modulator; Region: Pmp3; pfam01679 530564002550 Response regulator receiver domain; Region: Response_reg; pfam00072 530564002551 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564002552 active site 530564002553 phosphorylation site [posttranslational modification] 530564002554 intermolecular recognition site; other site 530564002555 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 530564002556 glycogen branching enzyme; Provisional; Region: PRK14706 530564002557 Alpha amylase catalytic domain found in Glycosyltrehalose trehalohydrolase (also called Maltooligosyl trehalose Trehalohydrolase); Region: AmyAc_GTHase; cd11325 530564002558 catalytic site [active] 530564002559 active site 530564002560 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 530564002561 Catalase-like heme-binding proteins similar to the uncharacterized y4iL; Region: y4iL_like; cd08152 530564002562 putative heme binding pocket [chemical binding]; other site 530564002563 arsenical pump-driving ATPase; Region: arsen_driv_ArsA; TIGR04291 530564002564 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 530564002565 P loop; other site 530564002566 Nucleotide binding site [chemical binding]; other site 530564002567 DTAP/Switch II; other site 530564002568 Switch I; other site 530564002569 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 530564002570 DTAP/Switch II; other site 530564002571 Switch I; other site 530564002572 Arsenical resistance operon trans-acting repressor ArsD; Region: ArsD; pfam06953 530564002573 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 530564002574 putative DNA binding site [nucleotide binding]; other site 530564002575 putative Zn2+ binding site [ion binding]; other site 530564002576 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 530564002577 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 530564002578 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 530564002579 Protein of unknown function (DUF3494); Region: DUF3494; pfam11999 530564002580 Cna protein B-type domain; Region: Cna_B; pfam05738 530564002581 Cna protein B-type domain; Region: Cna_B; pfam05738 530564002582 Protein of unknown function (DUF1551); Region: DUF1551; pfam07585 530564002583 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 530564002584 DNA binding residues [nucleotide binding] 530564002585 dimerization interface [polypeptide binding]; other site 530564002586 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 530564002587 HEAT repeats; Region: HEAT_2; pfam13646 530564002588 HEAT repeats; Region: HEAT_2; pfam13646 530564002589 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 530564002590 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 530564002591 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 530564002592 HlyD family secretion protein; Region: HlyD_3; pfam13437 530564002593 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 530564002594 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 530564002595 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 530564002596 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 530564002597 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 530564002598 FtsX-like permease family; Region: FtsX; pfam02687 530564002599 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 530564002600 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 530564002601 Walker A/P-loop; other site 530564002602 ATP binding site [chemical binding]; other site 530564002603 Q-loop/lid; other site 530564002604 ABC transporter signature motif; other site 530564002605 Walker B; other site 530564002606 D-loop; other site 530564002607 H-loop/switch region; other site 530564002608 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 530564002609 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 530564002610 FtsX-like permease family; Region: FtsX; pfam02687 530564002611 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 530564002612 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564002613 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564002614 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564002615 Sulfatase; Region: Sulfatase; cl17466 530564002616 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 530564002617 FOG: WD40 repeat [General function prediction only]; Region: COG2319 530564002618 structural tetrad; other site 530564002619 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 530564002620 D-galactonate transporter; Region: 2A0114; TIGR00893 530564002621 putative substrate translocation pore; other site 530564002622 cyclically-permuted mutarotase family protein; Region: mutarot_permut; TIGR03548 530564002623 Galactose oxidase, central domain; Region: Kelch_3; cl02701 530564002624 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cl00183 530564002625 dimerization interface [polypeptide binding]; other site 530564002626 putative active cleft [active] 530564002627 Protein of unknown function (DUF1624); Region: DUF1624; cl01394 530564002628 Acyltransferase family; Region: Acyl_transf_3; pfam01757 530564002629 Flavin containing amine oxidoreductase; Region: Amino_oxidase; pfam01593 530564002630 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 530564002631 Phosphoenolpyruvate carboxylase; Region: PEPcase; pfam00311 530564002632 Family description; Region: VCBS; pfam13517 530564002633 Family description; Region: VCBS; pfam13517 530564002634 ASPIC and UnbV; Region: UnbV_ASPIC; pfam07593 530564002635 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: MgtA; COG0474 530564002636 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; smart00831 530564002637 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 530564002638 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 530564002639 haloacid dehalogenase-like hydrolase; Region: HAD; pfam12710 530564002640 Soluble P-type ATPase [General function prediction only]; Region: COG4087 530564002641 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 530564002642 Transcription factor zinc-finger; Region: zf-TFIIB; cl01565 530564002643 Predicted permease; Region: DUF318; cl17795 530564002644 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 530564002645 cAMP-binding proteins - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]; Region: Crp; COG0664 530564002646 ligand binding site [chemical binding]; other site 530564002647 flexible hinge region; other site 530564002648 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 530564002649 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 530564002650 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 530564002651 Aminopeptidase P, N-terminal domain; Region: AMP_N; smart01011 530564002652 proline aminopeptidase P II; Provisional; Region: PRK10879 530564002653 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 530564002654 active site 530564002655 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 530564002656 siderophore transporter, RhtX/FptX family; Region: sider_RhtX_FptX; TIGR02718 530564002657 putative substrate translocation pore; other site 530564002658 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 530564002659 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 530564002660 hydroxyproline-2-epimerase; Provisional; Region: PRK13970 530564002661 hydroxyproline-2-epimerase; Provisional; Region: PRK13971 530564002662 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 530564002663 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 530564002664 inhibitor site; inhibition site 530564002665 active site 530564002666 dimer interface [polypeptide binding]; other site 530564002667 catalytic residue [active] 530564002668 Cytolysin, a secreted calcineurin-like phosphatase [Cell motility and secretion]; Region: COG5555 530564002669 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 530564002670 Cytolysin, a secreted calcineurin-like phosphatase [Cell motility and secretion]; Region: COG5555 530564002671 PAS fold; Region: PAS_4; pfam08448 530564002672 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 530564002673 putative active site [active] 530564002674 heme pocket [chemical binding]; other site 530564002675 Helix-turn-helix domain; Region: HTH_18; pfam12833 530564002676 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 530564002677 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 530564002678 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 530564002679 Putative zinc-finger; Region: zf-HC2; pfam13490 530564002680 RNA polymerase sigma factor SigW; Provisional; Region: PRK09641 530564002681 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 530564002682 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 530564002683 DNA binding residues [nucleotide binding] 530564002684 TMAO/DMSO reductase; Reviewed; Region: PRK05363 530564002685 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 530564002686 Moco binding site; other site 530564002687 metal coordination site [ion binding]; other site 530564002688 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 530564002689 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 530564002690 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 530564002691 FAD binding pocket [chemical binding]; other site 530564002692 FAD binding motif [chemical binding]; other site 530564002693 phosphate binding motif [ion binding]; other site 530564002694 beta-alpha-beta structure motif; other site 530564002695 NAD binding pocket [chemical binding]; other site 530564002696 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 530564002697 catalytic loop [active] 530564002698 iron binding site [ion binding]; other site 530564002699 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 530564002700 MarR family; Region: MarR; pfam01047 530564002701 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 530564002702 Trp docking motif [polypeptide binding]; other site 530564002703 active site 530564002704 PQQ-like domain; Region: PQQ_2; pfam13360 530564002705 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564002706 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 530564002707 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 530564002708 Protein export membrane protein; Region: SecD_SecF; cl14618 530564002709 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 530564002710 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 530564002711 HlyD family secretion protein; Region: HlyD_3; pfam13437 530564002712 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 530564002713 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 530564002714 dimer interface [polypeptide binding]; other site 530564002715 putative radical transfer pathway; other site 530564002716 diiron center [ion binding]; other site 530564002717 tyrosyl radical; other site 530564002718 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK07207 530564002719 ATP cone domain; Region: ATP-cone; pfam03477 530564002720 Class I ribonucleotide reductase; Region: RNR_I; cd01679 530564002721 active site 530564002722 dimer interface [polypeptide binding]; other site 530564002723 catalytic residues [active] 530564002724 effector binding site; other site 530564002725 R2 peptide binding site; other site 530564002726 S1/P1 nucleases and related enzymes; Region: S1-P1_nuclease; cd11010 530564002727 active site 530564002728 Zn binding site [ion binding]; other site 530564002729 Pectic acid lyase; Region: Pec_lyase; pfam09492 530564002730 Domain of unknown function (DUF3472); Region: DUF3472; pfam11958 530564002731 Penicillinase repressor; Region: Pencillinase_R; pfam03965 530564002732 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 530564002733 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564002734 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564002735 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564002736 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 530564002737 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 530564002738 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 530564002739 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 530564002740 FeS/SAM binding site; other site 530564002741 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 530564002742 Sulfatase; Region: Sulfatase; pfam00884 530564002743 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 530564002744 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 530564002745 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 530564002746 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 530564002747 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 530564002748 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 530564002749 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 530564002750 Calx-beta domain; Region: Calx-beta; cl02522 530564002751 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 530564002752 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 530564002753 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 530564002754 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 530564002755 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 530564002756 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 530564002757 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 530564002758 HEAT repeats; Region: HEAT_2; pfam13646 530564002759 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 530564002760 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 530564002761 Walker A/P-loop; other site 530564002762 ATP binding site [chemical binding]; other site 530564002763 Q-loop/lid; other site 530564002764 SMC proteins Flexible Hinge Domain; Region: SMC_hinge; smart00968 530564002765 ATP-binding cassette domain of barmotin, a member of the SMC protein family; Region: ABC_SMC_barmotin; cd03278 530564002766 ABC transporter signature motif; other site 530564002767 Walker B; other site 530564002768 D-loop; other site 530564002769 H-loop/switch region; other site 530564002770 AAA domain; Region: AAA_11; pfam13086 530564002771 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564002772 Walker A motif; other site 530564002773 ATP binding site [chemical binding]; other site 530564002774 Walker B motif; other site 530564002775 AAA domain; Region: AAA_12; pfam13087 530564002776 photolyase PhrII; Region: phr2; TIGR00591 530564002777 DNA photolyase; Region: DNA_photolyase; pfam00875 530564002778 Predicted NAD/FAD-dependent oxidoreductase [General function prediction only]; Region: COG3380 530564002779 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 530564002780 thymidylate synthase; Reviewed; Region: thyA; PRK01827 530564002781 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 530564002782 dimerization interface [polypeptide binding]; other site 530564002783 active site 530564002784 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 530564002785 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 530564002786 folate binding site [chemical binding]; other site 530564002787 NADP+ binding site [chemical binding]; other site 530564002788 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 530564002789 Beta-lactamase; Region: Beta-lactamase; pfam00144 530564002790 Protein of unknown function (DUF2721); Region: DUF2721; pfam11026 530564002791 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 530564002792 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 530564002793 trimerization site [polypeptide binding]; other site 530564002794 active site 530564002795 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 530564002796 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 530564002797 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 530564002798 catalytic residue [active] 530564002799 Conjugal transfer protein TrbE; Region: TrbE; cl10142 530564002800 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 530564002801 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 530564002802 Walker A/P-loop; other site 530564002803 ATP binding site [chemical binding]; other site 530564002804 Q-loop/lid; other site 530564002805 ABC transporter signature motif; other site 530564002806 Walker B; other site 530564002807 D-loop; other site 530564002808 H-loop/switch region; other site 530564002809 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 530564002810 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 530564002811 substrate binding pocket [chemical binding]; other site 530564002812 acetyl-CoA synthetase; Provisional; Region: PRK00174 530564002813 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 530564002814 active site 530564002815 CoA binding site [chemical binding]; other site 530564002816 acyl-activating enzyme (AAE) consensus motif; other site 530564002817 AMP binding site [chemical binding]; other site 530564002818 acetate binding site [chemical binding]; other site 530564002819 Sulfatase; Region: Sulfatase; cl17466 530564002820 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 530564002821 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 530564002822 Sulfatase; Region: Sulfatase; pfam00884 530564002823 Putative neutral zinc metallopeptidase; Region: Zn_peptidase_2; pfam04298 530564002824 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 530564002825 sulfite reductase subunit beta; Provisional; Region: PRK13504 530564002826 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 530564002827 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 530564002828 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 530564002829 S-adenosylmethionine synthetase; Validated; Region: PRK05250 530564002830 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 530564002831 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 530564002832 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 530564002833 ZIP Zinc transporter; Region: Zip; pfam02535 530564002834 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 530564002835 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 530564002836 Cell division protein FtsA; Region: FtsA; cl17206 530564002837 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 530564002838 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564002839 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564002840 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 530564002841 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 530564002842 glutaminase active site [active] 530564002843 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 530564002844 dimer interface [polypeptide binding]; other site 530564002845 active site 530564002846 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 530564002847 dimer interface [polypeptide binding]; other site 530564002848 active site 530564002849 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 530564002850 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 530564002851 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 530564002852 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cd00037 530564002853 ligand binding surface [chemical binding]; other site 530564002854 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cd00037 530564002855 ligand binding surface [chemical binding]; other site 530564002856 C-type lectin (CTL)/C-type lectin-like (CTLD) domain; Region: CLECT; cl02432 530564002857 ligand binding surface [chemical binding]; other site 530564002858 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 530564002859 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 530564002860 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 530564002861 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 530564002862 oligomerization interface [polypeptide binding]; other site 530564002863 active site 530564002864 metal binding site [ion binding]; metal-binding site 530564002865 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 530564002866 putative active site [active] 530564002867 catalytic triad [active] 530564002868 putative dimer interface [polypeptide binding]; other site 530564002869 SEC10/PgrA surface exclusion domain; Region: Surf_Exclu_PgrA; TIGR04320 530564002870 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; cl17312 530564002871 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 530564002872 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 530564002873 S-adenosylmethionine binding site [chemical binding]; other site 530564002874 Exonuclease-Endonuclease-Phosphatase domain; uncharacterized family 1; Region: EEP-1; cd09083 530564002875 putative catalytic site [active] 530564002876 putative metal binding site [ion binding]; other site 530564002877 putative phosphate binding site [ion binding]; other site 530564002878 DNA topoisomerase IV subunit A; Validated; Region: PRK05561 530564002879 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 530564002880 CAP-like domain; other site 530564002881 active site 530564002882 primary dimer interface [polypeptide binding]; other site 530564002883 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 530564002884 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 530564002885 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 530564002886 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 530564002887 Predicted UDP-glucose 6-dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: Ugd; COG1004 530564002888 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 530564002889 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 530564002890 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 530564002891 Methyltransferase domain; Region: Methyltransf_31; pfam13847 530564002892 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 530564002893 S-adenosylmethionine binding site [chemical binding]; other site 530564002894 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 530564002895 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 530564002896 Prenyltransferase-like; Region: Prenyltrans_1; pfam13243 530564002897 Methyltransferase domain; Region: Methyltransf_23; pfam13489 530564002898 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 530564002899 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 530564002900 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 530564002901 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 530564002902 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 530564002903 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 530564002904 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 530564002905 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 530564002906 ATP binding site [chemical binding]; other site 530564002907 Mg++ binding site [ion binding]; other site 530564002908 motif III; other site 530564002909 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 530564002910 nucleotide binding region [chemical binding]; other site 530564002911 ATP-binding site [chemical binding]; other site 530564002912 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 530564002913 dimerization interface [polypeptide binding]; other site 530564002914 putative DNA binding site [nucleotide binding]; other site 530564002915 putative Zn2+ binding site [ion binding]; other site 530564002916 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 530564002917 putative hydrophobic ligand binding site [chemical binding]; other site 530564002918 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 530564002919 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 530564002920 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 530564002921 UbiA prenyltransferase family; Region: UbiA; pfam01040 530564002922 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 530564002923 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 530564002924 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 530564002925 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 530564002926 dimer interface [polypeptide binding]; other site 530564002927 active site 530564002928 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 530564002929 thiamine biosynthesis protein ThiC; Region: thiC; TIGR00190 530564002930 ThiC family; Region: ThiC; pfam01964 530564002931 Uncharacterized bacterial subgroup of the DEDDy 3'-5' exonuclease domain of family-B DNA polymerases; Region: DNA_polB_like1_exo; cd05782 530564002932 active site 530564002933 catalytic site [active] 530564002934 substrate binding site [chemical binding]; other site 530564002935 Predicted 3'-5' exonuclease related to the exonuclease domain of PolB; Region: DNA_pol_B_exo2; pfam10108 530564002936 peptidase T; Region: peptidase-T; TIGR01882 530564002937 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 530564002938 metal binding site [ion binding]; metal-binding site 530564002939 dimer interface [polypeptide binding]; other site 530564002940 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 530564002941 active site 530564002942 Dynamin family; Region: Dynamin_N; pfam00350 530564002943 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 530564002944 G1 box; other site 530564002945 GTP/Mg2+ binding site [chemical binding]; other site 530564002946 Switch I region; other site 530564002947 G2 box; other site 530564002948 Switch II region; other site 530564002949 G3 box; other site 530564002950 G4 box; other site 530564002951 G5 box; other site 530564002952 Domain of unknown function (DUF697); Region: DUF697; pfam05128 530564002953 E. coli Ras-like protein (Era)-like GTPase; Region: Era_like; cd00880 530564002954 G1 box; other site 530564002955 GTP/Mg2+ binding site [chemical binding]; other site 530564002956 Switch I region; other site 530564002957 G2 box; other site 530564002958 Switch II region; other site 530564002959 G3 box; other site 530564002960 G4 box; other site 530564002961 Domain of unknown function (DUF697); Region: DUF697; pfam05128 530564002962 2-acyl-glycerophospho-ethanolamine acyltransferase; Validated; Region: PRK08633 530564002963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 530564002964 putative substrate translocation pore; other site 530564002965 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 530564002966 putative acyl-acceptor binding pocket; other site 530564002967 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 530564002968 acyl-activating enzyme (AAE) consensus motif; other site 530564002969 AMP binding site [chemical binding]; other site 530564002970 active site 530564002971 CoA binding site [chemical binding]; other site 530564002972 Uncharacterized enzyme involved in biosynthesis of extracellular polysaccharides [General function prediction only]; Region: COG2329 530564002973 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 530564002974 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 530564002975 catalytic triad [active] 530564002976 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 530564002977 active site 530564002978 catalytic residues [active] 530564002979 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 530564002980 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 530564002981 DNA binding residues [nucleotide binding] 530564002982 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 530564002983 protein binding site [polypeptide binding]; other site 530564002984 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 530564002985 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 530564002986 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 530564002987 Glucuronate isomerase; Region: UxaC; cl00829 530564002988 PAS fold; Region: PAS_4; pfam08448 530564002989 PAS domain S-box; Region: sensory_box; TIGR00229 530564002990 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 530564002991 putative active site [active] 530564002992 heme pocket [chemical binding]; other site 530564002993 PAS domain S-box; Region: sensory_box; TIGR00229 530564002994 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 530564002995 putative active site [active] 530564002996 heme pocket [chemical binding]; other site 530564002997 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 530564002998 dimer interface [polypeptide binding]; other site 530564002999 phosphorylation site [posttranslational modification] 530564003000 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 530564003001 ATP binding site [chemical binding]; other site 530564003002 Mg2+ binding site [ion binding]; other site 530564003003 G-X-G motif; other site 530564003004 Response regulator receiver domain; Region: Response_reg; pfam00072 530564003005 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564003006 active site 530564003007 phosphorylation site [posttranslational modification] 530564003008 intermolecular recognition site; other site 530564003009 dimerization interface [polypeptide binding]; other site 530564003010 Putative protein-S-isoprenylcysteine methyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: STE14; COG2020 530564003011 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 530564003012 dimerization interface [polypeptide binding]; other site 530564003013 putative DNA binding site [nucleotide binding]; other site 530564003014 putative Zn2+ binding site [ion binding]; other site 530564003015 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 530564003016 Catalytic domain of Protein Kinases; Region: PKc; cd00180 530564003017 active site 530564003018 ATP binding site [chemical binding]; other site 530564003019 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 530564003020 substrate binding site [chemical binding]; other site 530564003021 activation loop (A-loop); other site 530564003022 acetyl-CoA carboxylase, carboxyl transferase, beta subunit; Region: accD; TIGR00515 530564003023 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 530564003024 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 530564003025 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 530564003026 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 530564003027 substrate binding site [chemical binding]; other site 530564003028 hexamer interface [polypeptide binding]; other site 530564003029 metal binding site [ion binding]; metal-binding site 530564003030 Fe-S oxidoreductase [Energy production and conversion]; Region: COG1032 530564003031 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 530564003032 B12 binding site [chemical binding]; other site 530564003033 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 530564003034 FeS/SAM binding site; other site 530564003035 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; pfam13505 530564003036 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 530564003037 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 530564003038 ligand binding site; other site 530564003039 oligomer interface; other site 530564003040 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 530564003041 dimer interface [polypeptide binding]; other site 530564003042 N-terminal domain interface [polypeptide binding]; other site 530564003043 sulfate 1 binding site; other site 530564003044 exosortase A system-associated amidotransferase 1; Region: eps_aminotran_1; TIGR03108 530564003045 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 530564003046 active site 530564003047 dimer interface [polypeptide binding]; other site 530564003048 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 530564003049 Ligand Binding Site [chemical binding]; other site 530564003050 Molecular Tunnel; other site 530564003051 Domain III of Elongation factor (EF) Tu (EF-TU) and EF-G. Elongation factors (EF) EF-Tu and EF-G participate in the elongation phase during protein biosynthesis on the ribosome. Their functional cycles depend on GTP binding and its hydrolysis. The EF-Tu...; Region: Translation_factor_III; cl02786 530564003052 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564003053 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564003054 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564003055 Trehalose utilisation; Region: ThuA; pfam06283 530564003056 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 530564003057 HEAT repeats; Region: HEAT_2; pfam13646 530564003058 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 530564003059 Flp pilus assembly protein TadC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: TadC; COG2064 530564003060 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 530564003061 Flp pilus assembly protein TadB [Intracellular trafficking and secretion]; Region: TadB; COG4965 530564003062 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 530564003063 Flp pilus assembly protein, ATPase CpaF [Intracellular trafficking and secretion]; Region: CpaF; COG4962 530564003064 Type IV secretory pathway component VirB11, and related ATPases. The homohexamer, VirB11 is one of eleven Vir proteins, which are required for T-pilus biogenesis and virulence in the transfer of T-DNA from the Ti (tumor-inducing) plasmid of bacterial to...; Region: VirB11-like_ATPase; cd01130 530564003065 ATP binding site [chemical binding]; other site 530564003066 Walker A motif; other site 530564003067 hexamer interface [polypeptide binding]; other site 530564003068 Walker B motif; other site 530564003069 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 530564003070 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 530564003071 Ligand binding site; other site 530564003072 Putative Catalytic site; other site 530564003073 DXD motif; other site 530564003074 DegT/DnrJ/EryC1/StrS aminotransferase family; Region: DegT_DnrJ_EryC1; pfam01041 530564003075 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 530564003076 inhibitor-cofactor binding pocket; inhibition site 530564003077 pyridoxal 5'-phosphate binding site [chemical binding]; other site 530564003078 catalytic residue [active] 530564003079 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 530564003080 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 530564003081 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 530564003082 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 530564003083 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 530564003084 putative trimer interface [polypeptide binding]; other site 530564003085 putative active site [active] 530564003086 putative substrate binding site [chemical binding]; other site 530564003087 putative CoA binding site [chemical binding]; other site 530564003088 hypothetical protein; Provisional; Region: PRK07233 530564003089 Putative catalytic domain of uncharacterized bacterial polysaccharide deacetylases similar to bacterial PuuE allantoinases and Helicobacter pylori peptidoglycan deacetylase (HpPgdA); Region: CE4_PuuE_HpPgdA_like_1; cd10940 530564003090 putative active site [active] 530564003091 putative catalytic site [active] 530564003092 putative Zn binding site [ion binding]; other site 530564003093 Predicted xylanase/chitin deacetylase [Carbohydrate transport and metabolism]; Region: CDA1; COG0726 530564003094 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 530564003095 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 530564003096 active site 530564003097 homodimer interface [polypeptide binding]; other site 530564003098 Bacterial sugar transferase; Region: Bac_transf; pfam02397 530564003099 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 530564003100 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 530564003101 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 530564003102 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 530564003103 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 530564003104 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 530564003105 active site 530564003106 metal binding site [ion binding]; metal-binding site 530564003107 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 530564003108 Coenzyme A binding pocket [chemical binding]; other site 530564003109 hypothetical protein; Provisional; Region: PRK12378 530564003110 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 530564003111 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 530564003112 DNA-binding site [nucleotide binding]; DNA binding site 530564003113 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 530564003114 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 530564003115 intersubunit interface [polypeptide binding]; other site 530564003116 active site 530564003117 catalytic residue [active] 530564003118 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 530564003119 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 530564003120 Cytochrome c; Region: Cytochrom_C; pfam00034 530564003121 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 530564003122 Sulfatase; Region: Sulfatase; cl17466 530564003123 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564003124 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 530564003125 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 530564003126 Sulfatase; Region: Sulfatase; pfam00884 530564003127 DoxX-like family; Region: DoxX_2; pfam13564 530564003128 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 530564003129 Dynamin family; Region: Dynamin_N; pfam00350 530564003130 G1 box; other site 530564003131 GTP/Mg2+ binding site [chemical binding]; other site 530564003132 G2 box; other site 530564003133 Switch I region; other site 530564003134 Dynamin-like protein including dynamins, mitofusins, and guanylate-binding proteins; Region: DLP_2; cd09912 530564003135 G3 box; other site 530564003136 Switch II region; other site 530564003137 GTP/Mg2+ binding site [chemical binding]; other site 530564003138 G4 box; other site 530564003139 G5 box; other site 530564003140 Double zinc ribbon; Region: DZR; pfam12773 530564003141 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 530564003142 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 530564003143 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 530564003144 Dynamin family; Region: Dynamin_N; pfam00350 530564003145 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 530564003146 G1 box; other site 530564003147 GTP/Mg2+ binding site [chemical binding]; other site 530564003148 G2 box; other site 530564003149 Switch I region; other site 530564003150 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 530564003151 G3 box; other site 530564003152 Switch II region; other site 530564003153 GTP/Mg2+ binding site [chemical binding]; other site 530564003154 G4 box; other site 530564003155 G5 box; other site 530564003156 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 530564003157 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 530564003158 DNA binding residues [nucleotide binding] 530564003159 Type II secretory pathway pseudopilin; Region: PulG; pfam11773 530564003160 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564003161 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 530564003162 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 530564003163 Cl- selectivity filter; other site 530564003164 Cl- binding residues [ion binding]; other site 530564003165 pore gating glutamate residue; other site 530564003166 dimer interface [polypeptide binding]; other site 530564003167 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 530564003168 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 530564003169 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 530564003170 protein binding site [polypeptide binding]; other site 530564003171 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 530564003172 protein binding site [polypeptide binding]; other site 530564003173 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 530564003174 PQQ-like domain; Region: PQQ_2; pfam13360 530564003175 Trp docking motif [polypeptide binding]; other site 530564003176 active site 530564003177 Uncharacterized conserved protein [Function unknown]; Region: COG1479 530564003178 Protein of unknown function DUF262; Region: DUF262; pfam03235 530564003179 Protein of unknown function DUF262; Region: DUF262; pfam03235 530564003180 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 530564003181 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 530564003182 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 530564003183 non-specific DNA binding site [nucleotide binding]; other site 530564003184 salt bridge; other site 530564003185 sequence-specific DNA binding site [nucleotide binding]; other site 530564003186 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 530564003187 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 530564003188 putative ligand binding site [chemical binding]; other site 530564003189 putative NAD binding site [chemical binding]; other site 530564003190 catalytic site [active] 530564003191 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 530564003192 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 530564003193 catalytic residues [active] 530564003194 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 530564003195 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 530564003196 catalytic residues [active] 530564003197 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 530564003198 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 530564003199 catalytic residues [active] 530564003200 PCD_DCoH: The bifunctional protein pterin-4alpha-carbinolamine dehydratase (PCD), also known as DCoH (dimerization cofactor of hepatocyte nuclear factor-1), is both a transcription activator and a metabolic enzyme. DCoH stimulates gene expression by...; Region: PCD_DCoH; cd00488 530564003201 aromatic arch; other site 530564003202 DCoH dimer interaction site [polypeptide binding]; other site 530564003203 DCoH /HNF-1 dimer interaction site [polypeptide binding]; other site 530564003204 DCoH tetramer interaction site [polypeptide binding]; other site 530564003205 substrate binding site [chemical binding]; other site 530564003206 Response regulator receiver domain; Region: Response_reg; pfam00072 530564003207 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564003208 active site 530564003209 phosphorylation site [posttranslational modification] 530564003210 intermolecular recognition site; other site 530564003211 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 530564003212 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 530564003213 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 530564003214 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 530564003215 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 530564003216 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 530564003217 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 530564003218 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 530564003219 putative metal binding site [ion binding]; other site 530564003220 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 530564003221 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 530564003222 putative metal binding site [ion binding]; other site 530564003223 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564003224 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 530564003225 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 530564003226 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 530564003227 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 530564003228 active site 530564003229 dimer interface [polypeptide binding]; other site 530564003230 motif 1; other site 530564003231 motif 2; other site 530564003232 motif 3; other site 530564003233 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 530564003234 anticodon binding site; other site 530564003235 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 530564003236 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 530564003237 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 530564003238 MarR family; Region: MarR_2; cl17246 530564003239 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 530564003240 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 530564003241 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 530564003242 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 530564003243 Ankyrin repeats (many copies); Region: Ank_4; pfam13637 530564003244 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 530564003245 Putative addiction module component; Region: Unstab_antitox; pfam09720 530564003246 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 530564003247 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 530564003248 Outer membrane efflux protein; Region: OEP; pfam02321 530564003249 Outer membrane efflux protein; Region: OEP; pfam02321 530564003250 TspO/MBR family; Region: TspO_MBR; pfam03073 530564003251 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; COG1914 530564003252 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564003253 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 530564003254 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564003255 Walker A motif; other site 530564003256 ATP binding site [chemical binding]; other site 530564003257 Walker B motif; other site 530564003258 arginine finger; other site 530564003259 AAA domain; Region: AAA_31; pfam13614 530564003260 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 530564003261 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 530564003262 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 530564003263 substrate binding pocket [chemical binding]; other site 530564003264 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 530564003265 B12 binding site [chemical binding]; other site 530564003266 cobalt ligand [ion binding]; other site 530564003267 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 530564003268 Integral membrane protein TerC family; Region: TerC; cl10468 530564003269 Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond...; Region: LRR_RI; cl15309 530564003270 Leucine rich repeat; Region: LRR_8; pfam13855 530564003271 Leucine-rich repeats; other site 530564003272 Substrate binding site [chemical binding]; other site 530564003273 Methyltransferase domain; Region: Methyltransf_23; pfam13489 530564003274 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 530564003275 S-adenosylmethionine binding site [chemical binding]; other site 530564003276 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 530564003277 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 530564003278 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 530564003279 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 530564003280 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 530564003281 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 530564003282 ATP-grasp domain; Region: ATP-grasp_4; cl17255 530564003283 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 530564003284 IMP binding site; other site 530564003285 dimer interface [polypeptide binding]; other site 530564003286 interdomain contacts; other site 530564003287 partial ornithine binding site; other site 530564003288 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564003289 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564003290 Protein of unknown function (DUF1294); Region: DUF1294; pfam06961 530564003291 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 530564003292 AP endonuclease family 2 C terminus; Region: AP_endonuc_2_N; pfam07582 530564003293 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 530564003294 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 530564003295 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 530564003296 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 530564003297 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 530564003298 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 530564003299 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 530564003300 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 530564003301 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 530564003302 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 530564003303 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 530564003304 homodimer interface [polypeptide binding]; other site 530564003305 substrate-cofactor binding pocket; other site 530564003306 pyridoxal 5'-phosphate binding site [chemical binding]; other site 530564003307 catalytic residue [active] 530564003308 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 530564003309 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 530564003310 Na binding site [ion binding]; other site 530564003311 Protein of unknown function, DUF485; Region: DUF485; cl01231 530564003312 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 530564003313 putative DNA binding site [nucleotide binding]; other site 530564003314 dimerization interface [polypeptide binding]; other site 530564003315 putative Zn2+ binding site [ion binding]; other site 530564003316 O-methyltransferase; Region: Methyltransf_2; pfam00891 530564003317 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 530564003318 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 530564003319 CAAX protease self-immunity; Region: Abi; pfam02517 530564003320 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 530564003321 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 530564003322 Walker A/P-loop; other site 530564003323 ATP binding site [chemical binding]; other site 530564003324 Q-loop/lid; other site 530564003325 ABC transporter signature motif; other site 530564003326 Walker B; other site 530564003327 D-loop; other site 530564003328 H-loop/switch region; other site 530564003329 Sulfite exporter TauE/SafE; Region: TauE; pfam01925 530564003330 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 530564003331 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 530564003332 active site 530564003333 substrate-binding site [chemical binding]; other site 530564003334 metal-binding site [ion binding] 530564003335 ATP binding site [chemical binding]; other site 530564003336 Response regulator receiver domain; Region: Response_reg; pfam00072 530564003337 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564003338 active site 530564003339 phosphorylation site [posttranslational modification] 530564003340 intermolecular recognition site; other site 530564003341 dimerization interface [polypeptide binding]; other site 530564003342 MoxR-like ATPases [General function prediction only]; Region: COG0714 530564003343 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564003344 Walker A motif; other site 530564003345 ATP binding site [chemical binding]; other site 530564003346 Walker B motif; other site 530564003347 arginine finger; other site 530564003348 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 530564003349 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 530564003350 metal ion-dependent adhesion site (MIDAS); other site 530564003351 HEAT repeats; Region: HEAT_2; pfam13646 530564003352 HEAT repeats; Region: HEAT_2; pfam13646 530564003353 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 530564003354 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 530564003355 putative metal binding site [ion binding]; other site 530564003356 Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence...; Region: PP2Cc; cd00143 530564003357 Protein phosphatase 2C; Region: PP2C; pfam00481 530564003358 active site 530564003359 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 530564003360 23S rRNA interface [nucleotide binding]; other site 530564003361 L3 interface [polypeptide binding]; other site 530564003362 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 530564003363 Class I aldolases; Region: Aldolase_Class_I; cl17187 530564003364 catalytic residue [active] 530564003365 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in mouse RS21-C6 protein and its homologs; Region: NTP-PPase_RS21-C6_like; cd11537 530564003366 homodimer interface [polypeptide binding]; other site 530564003367 chemical substrate binding site [chemical binding]; other site 530564003368 oligomer interface [polypeptide binding]; other site 530564003369 metal binding site [ion binding]; metal-binding site 530564003370 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 530564003371 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 530564003372 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 530564003373 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 530564003374 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 530564003375 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 530564003376 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 530564003377 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 530564003378 Domon-like ligand-binding domains; Region: DOMON_like; cd00241 530564003379 putative ligand binding site [chemical binding]; other site 530564003380 Uncharacterized conserved protein [Function unknown]; Region: COG0398 530564003381 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 530564003382 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 530564003383 Protein of unknown function DUF58; Region: DUF58; pfam01882 530564003384 MoxR-like ATPases [General function prediction only]; Region: COG0714 530564003385 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564003386 Walker A motif; other site 530564003387 ATP binding site [chemical binding]; other site 530564003388 Walker B motif; other site 530564003389 arginine finger; other site 530564003390 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 530564003391 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 530564003392 dimer interface [polypeptide binding]; other site 530564003393 ADP-ribose binding site [chemical binding]; other site 530564003394 active site 530564003395 nudix motif; other site 530564003396 metal binding site [ion binding]; metal-binding site 530564003397 Yhdh and yhfp-like putative quinone oxidoreductases; Region: MDR_yhdh_yhfp; cd05280 530564003398 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 530564003399 NADP binding site [chemical binding]; other site 530564003400 dimer interface [polypeptide binding]; other site 530564003401 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 530564003402 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 530564003403 catalytic residues [active] 530564003404 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 530564003405 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 530564003406 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 530564003407 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 530564003408 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 530564003409 acyl carrier protein; Provisional; Region: acpP; PRK00982 530564003410 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 530564003411 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 530564003412 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 530564003413 dimer interface [polypeptide binding]; other site 530564003414 active site 530564003415 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 530564003416 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 530564003417 Hemerythrin HHE cation binding domain; Region: Hemerythrin; pfam01814 530564003418 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 530564003419 Ligand Binding Site [chemical binding]; other site 530564003420 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 530564003421 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564003422 active site 530564003423 phosphorylation site [posttranslational modification] 530564003424 intermolecular recognition site; other site 530564003425 dimerization interface [polypeptide binding]; other site 530564003426 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564003427 Walker A motif; other site 530564003428 ATP binding site [chemical binding]; other site 530564003429 Walker B motif; other site 530564003430 arginine finger; other site 530564003431 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 530564003432 superfamily containing globins and truncated hemoglobins; Region: globin_like; cl00280 530564003433 heme-binding site [chemical binding]; other site 530564003434 Signal transduction histidine kinase, nitrogen specific [Signal transduction mechanisms]; Region: NtrB; COG3852 530564003435 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 530564003436 dimer interface [polypeptide binding]; other site 530564003437 phosphorylation site [posttranslational modification] 530564003438 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 530564003439 ATP binding site [chemical binding]; other site 530564003440 Mg2+ binding site [ion binding]; other site 530564003441 G-X-G motif; other site 530564003442 Lhr-like helicases [General function prediction only]; Region: Lhr; COG1201 530564003443 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 530564003444 ATP binding site [chemical binding]; other site 530564003445 putative Mg++ binding site [ion binding]; other site 530564003446 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 530564003447 nucleotide binding region [chemical binding]; other site 530564003448 ATP-binding site [chemical binding]; other site 530564003449 DEAD/H associated; Region: DEAD_assoc; pfam08494 530564003450 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 530564003451 Transglycosylase associated protein; Region: Transgly_assoc; cl00978 530564003452 Transketolase [Carbohydrate transport and metabolism]; Region: TktA; COG0021 530564003453 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 530564003454 TPP-binding site [chemical binding]; other site 530564003455 dimer interface [polypeptide binding]; other site 530564003456 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 530564003457 PYR/PP interface [polypeptide binding]; other site 530564003458 dimer interface [polypeptide binding]; other site 530564003459 TPP binding site [chemical binding]; other site 530564003460 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 530564003461 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 530564003462 FOG: WD40 repeat [General function prediction only]; Region: COG2319 530564003463 structural tetrad; other site 530564003464 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564003465 Protein of unknown function (DUF229); Region: DUF229; pfam02995 530564003466 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564003467 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564003468 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 530564003469 Beta-lactamase; Region: Beta-lactamase; pfam00144 530564003470 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 530564003471 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 530564003472 catalytic residues [active] 530564003473 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 530564003474 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 530564003475 active site 530564003476 metal binding site [ion binding]; metal-binding site 530564003477 PilZ domain; Region: PilZ; pfam07238 530564003478 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 530564003479 Predicted flavoprotein [General function prediction only]; Region: COG0431 530564003480 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 530564003481 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 530564003482 dimerization interface [polypeptide binding]; other site 530564003483 DPS ferroxidase diiron center [ion binding]; other site 530564003484 ion pore; other site 530564003485 Predicted membrane protein [Function unknown]; Region: COG2259 530564003486 Pirin-related protein [General function prediction only]; Region: COG1741 530564003487 Pirin; Region: Pirin; pfam02678 530564003488 MarR family; Region: MarR_2; cl17246 530564003489 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 530564003490 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 530564003491 formylmethanofuran dehydrogenase subunit B; Region: one_C_dehyd_B; TIGR03129 530564003492 molybdopterin cofactor binding site; other site 530564003493 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 530564003494 CoA-disulfide reductase; Region: CoA_CoA_reduc; TIGR03385 530564003495 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 530564003496 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 530564003497 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 530564003498 Member of the Rhodanese Homology Domain superfamily. Included in this CD are the Lactococcus lactis NADH oxidase, Bacillus cereus NADH dehydrogenase, and Bacteroides thetaiotaomicron pyridine nucleotide-disulphide oxidoreductase, and similar...; Region: RHOD_Pyr_redox; cd01524 530564003499 active site residue [active] 530564003500 helicase 45; Provisional; Region: PTZ00424 530564003501 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 530564003502 ATP binding site [chemical binding]; other site 530564003503 Mg++ binding site [ion binding]; other site 530564003504 motif III; other site 530564003505 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 530564003506 nucleotide binding region [chemical binding]; other site 530564003507 ATP-binding site [chemical binding]; other site 530564003508 aminoacyl-tRNA ligase; Region: PLN02563 530564003509 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 530564003510 HIGH motif; other site 530564003511 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 530564003512 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 530564003513 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 530564003514 active site 530564003515 KMSKS motif; other site 530564003516 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 530564003517 tRNA binding surface [nucleotide binding]; other site 530564003518 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 530564003519 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 530564003520 active site 530564003521 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 530564003522 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 530564003523 metal ion-dependent adhesion site (MIDAS); other site 530564003524 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 530564003525 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 530564003526 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 530564003527 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 530564003528 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 530564003529 S-adenosylmethionine binding site [chemical binding]; other site 530564003530 Protein of unknown function (DUF1365); Region: DUF1365; pfam07103 530564003531 Predicted NAD/FAD-binding protein [General function prediction only]; Region: COG2907 530564003532 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 530564003533 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 530564003534 putative hydrophobic ligand binding site [chemical binding]; other site 530564003535 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 530564003536 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 530564003537 putative NAD(P) binding site [chemical binding]; other site 530564003538 putative active site [active] 530564003539 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 530564003540 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 530564003541 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 530564003542 DNA binding residues [nucleotide binding] 530564003543 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 530564003544 DNA binding residues [nucleotide binding] 530564003545 B12 binding domain; Region: B12-binding_2; pfam02607 530564003546 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 530564003547 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 530564003548 PQQ-like domain; Region: PQQ_2; pfam13360 530564003549 Trp docking motif [polypeptide binding]; other site 530564003550 active site 530564003551 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 530564003552 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 530564003553 Cytochrome c; Region: Cytochrom_C; pfam00034 530564003554 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 530564003555 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 530564003556 dimer interface [polypeptide binding]; other site 530564003557 active site 530564003558 uncharacterized radical SAM protein YgiQ; Region: SAM_YgiQ; TIGR03904 530564003559 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 530564003560 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 530564003561 This family is most closely related to the GT1 family of glycosyltransferases. WbnK in Shigella dysenteriae has been shown to be involved in the type 7 O-antigen biosynthesis; Region: GT1_WbnK_like; cd03807 530564003562 sugar transferase, PEP-CTERM/EpsH1 system associated; Region: stp2; TIGR03088 530564003563 putative ADP-binding pocket [chemical binding]; other site 530564003564 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 530564003565 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 530564003566 Pyrimidine operon attenuation protein/uracil phosphoribosyltransferase [Nucleotide transport and metabolism]; Region: PyrR; COG2065 530564003567 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 530564003568 active site 530564003569 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 530564003570 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 530564003571 putative catalytic residue [active] 530564003572 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 530564003573 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 530564003574 catalytic residues [active] 530564003575 Beta-lactamase enzyme family; Region: Beta-lactamase2; pfam13354 530564003576 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 530564003577 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 530564003578 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 530564003579 Chlam_Verruc_Plancto small basic protein; Region: Chlam_Ver_rRNA; TIGR04137 530564003580 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 530564003581 Trp docking motif [polypeptide binding]; other site 530564003582 PQQ-like domain; Region: PQQ_2; pfam13360 530564003583 active site 530564003584 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 530564003585 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 530564003586 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 530564003587 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 530564003588 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 530564003589 catalytic residue [active] 530564003590 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564003591 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 530564003592 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564003593 Response regulator receiver domain; Region: Response_reg; pfam00072 530564003594 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564003595 active site 530564003596 phosphorylation site [posttranslational modification] 530564003597 intermolecular recognition site; other site 530564003598 dimerization interface [polypeptide binding]; other site 530564003599 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 530564003600 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 530564003601 metal binding site [ion binding]; metal-binding site 530564003602 active site 530564003603 I-site; other site 530564003604 FOG: CBS domain [General function prediction only]; Region: COG0517 530564003605 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 530564003606 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 530564003607 active site 530564003608 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564003609 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564003610 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564003611 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 530564003612 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 530564003613 phosphopeptide binding site; other site 530564003614 Protein of unknown function (DUF1499); Region: DUF1499; pfam07386 530564003615 recombination factor protein RarA; Reviewed; Region: PRK13342 530564003616 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564003617 Walker A motif; other site 530564003618 ATP binding site [chemical binding]; other site 530564003619 Walker B motif; other site 530564003620 arginine finger; other site 530564003621 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 530564003622 Predicted membrane protein [Function unknown]; Region: COG2259 530564003623 putative sialic acid transporter; Region: 2A0112; TIGR00891 530564003624 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 530564003625 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 530564003626 dihydroorotase; Provisional; Region: PRK07575 530564003627 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 530564003628 Dihydroorotase (DHOase), subgroup IIb; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This group contains the archeal members of the DHOase family; Region: DHOase_IIb; cd01318 530564003629 active site 530564003630 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 530564003631 Trp docking motif [polypeptide binding]; other site 530564003632 active site 530564003633 PQQ-like domain; Region: PQQ_2; pfam13360 530564003634 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 530564003635 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 530564003636 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 530564003637 Creatinine amidohydrolase; Region: Creatininase; pfam02633 530564003638 PUA domain; Region: PUA; cl00607 530564003639 Predicted SAM-dependent methyltransferases [General function prediction only]; Region: COG1092 530564003640 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 530564003641 putative RNA binding site [nucleotide binding]; other site 530564003642 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 530564003643 S-adenosylmethionine binding site [chemical binding]; other site 530564003644 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 530564003645 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 530564003646 phosphate binding site [ion binding]; other site 530564003647 Cupin domain; Region: Cupin_2; cl17218 530564003648 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 530564003649 active site 530564003650 PQQ-like domain; Region: PQQ_2; pfam13360 530564003651 Trp docking motif [polypeptide binding]; other site 530564003652 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 530564003653 Trp docking motif [polypeptide binding]; other site 530564003654 active site 530564003655 PQQ-like domain; Region: PQQ_2; pfam13360 530564003656 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cl17736 530564003657 active site 530564003658 phosphorylation site [posttranslational modification] 530564003659 intermolecular recognition site; other site 530564003660 TM2 domain; Region: TM2; pfam05154 530564003661 SurA N-terminal domain; Region: SurA_N_3; cl07813 530564003662 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 530564003663 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 530564003664 active site 530564003665 Zn binding site [ion binding]; other site 530564003666 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 530564003667 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 530564003668 Coenzyme A binding pocket [chemical binding]; other site 530564003669 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 530564003670 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 530564003671 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 530564003672 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 530564003673 Uncharacterized conserved protein (DUF2294); Region: DUF2294; cl02390 530564003674 Response regulator receiver domain; Region: Response_reg; pfam00072 530564003675 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564003676 active site 530564003677 phosphorylation site [posttranslational modification] 530564003678 intermolecular recognition site; other site 530564003679 dimerization interface [polypeptide binding]; other site 530564003680 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 530564003681 RNA binding site [nucleotide binding]; other site 530564003682 FKBP-type peptidyl-prolyl cis-trans isomerases 2 [Posttranslational modification, protein turnover, chaperones]; Region: SlpA; COG1047 530564003683 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 530564003684 This family is most closely related to the GT1 family of glycosyltransferases. ORF704 in E. coli has been shown to be involved in the biosynthesis of O-specific mannose homopolysaccharides; Region: GT1_ecORF704_like; cd03822 530564003685 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 530564003686 Predicted glycosylase [Carbohydrate transport and metabolism]; Region: COG2152 530564003687 Domain of unknown function (DUF377); Region: DUF377; pfam04041 530564003688 active site 530564003689 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 530564003690 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 530564003691 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 530564003692 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 530564003693 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N_2; pfam13588 530564003694 DNA alkylation repair enzyme; Region: DNA_alkylation; pfam08713 530564003695 A new structural DNA glycosylase; Region: AlkD_like; cd06561 530564003696 active site 530564003697 Domain of unknown function (DUF1851); Region: DUF1851; pfam08906 530564003698 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 530564003699 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 530564003700 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 530564003701 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 530564003702 DNA binding site [nucleotide binding] 530564003703 active site 530564003704 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 530564003705 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 530564003706 TM2 domain; Region: TM2; pfam05154 530564003707 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 530564003708 ThiS interaction site; other site 530564003709 putative active site [active] 530564003710 tetramer interface [polypeptide binding]; other site 530564003711 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 530564003712 thiS-thiF/thiG interaction site; other site 530564003713 SseB protein; Region: SseB; cl06279 530564003714 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 530564003715 hopene-associated glycosyltransferase HpnB; Region: HpnB; TIGR03469 530564003716 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 530564003717 DXD motif; other site 530564003718 PemK-like protein; Region: PemK; pfam02452 530564003719 Amidohydrolase; Region: Amidohydro_2; pfam04909 530564003720 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 530564003721 Cytochrome c; Region: Cytochrom_C; cl11414 530564003722 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 530564003723 50S ribosomal protein L32; Reviewed; Region: rpmF; PRK12286 530564003724 [acyl-carrier protein] S-malonyltransferase; Region: PLN02752 530564003725 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 530564003726 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 530564003727 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 530564003728 NAD(P) binding site [chemical binding]; other site 530564003729 homotetramer interface [polypeptide binding]; other site 530564003730 homodimer interface [polypeptide binding]; other site 530564003731 active site 530564003732 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 530564003733 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 530564003734 active site 530564003735 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 530564003736 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 530564003737 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 530564003738 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 530564003739 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 530564003740 Walker A/P-loop; other site 530564003741 ATP binding site [chemical binding]; other site 530564003742 Q-loop/lid; other site 530564003743 ABC transporter signature motif; other site 530564003744 Walker B; other site 530564003745 D-loop; other site 530564003746 H-loop/switch region; other site 530564003747 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 530564003748 Nucleoside H+ symporter; Region: Nuc_H_symport; pfam03825 530564003749 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 530564003750 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 530564003751 active site 530564003752 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 530564003753 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 530564003754 Walker A/P-loop; other site 530564003755 ATP binding site [chemical binding]; other site 530564003756 Q-loop/lid; other site 530564003757 ABC transporter signature motif; other site 530564003758 Walker B; other site 530564003759 D-loop; other site 530564003760 H-loop/switch region; other site 530564003761 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 530564003762 FtsX-like permease family; Region: FtsX; pfam02687 530564003763 ABC-type transport system, involved in lipoprotein release, permease component [Cell envelope biogenesis, outer membrane]; Region: LolE; COG4591 530564003764 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 530564003765 FtsX-like permease family; Region: FtsX; pfam02687 530564003766 Phosphorylase superfamily; Region: PNP_UDP_1; pfam01048 530564003767 hopanoid biosynthesis associated radical SAM protein HpnH; Region: HpnH; TIGR03470 530564003768 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 530564003769 FeS/SAM binding site; other site 530564003770 Domain of unknown function (DUF3463); Region: DUF3463; pfam11946 530564003771 squalene-hopene cyclase; Region: hopene_cyclase; TIGR01507 530564003772 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 530564003773 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 530564003774 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 530564003775 short chain dehydrogenase; Provisional; Region: PRK06172 530564003776 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 530564003777 NAD(P) binding site [chemical binding]; other site 530564003778 active site 530564003779 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 530564003780 Trp docking motif [polypeptide binding]; other site 530564003781 active site 530564003782 PQQ-like domain; Region: PQQ_2; pfam13360 530564003783 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564003784 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 530564003785 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 530564003786 substrate binding site [chemical binding]; other site 530564003787 glutamase interaction surface [polypeptide binding]; other site 530564003788 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 530564003789 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 530564003790 Walker A motif; other site 530564003791 ATP binding site [chemical binding]; other site 530564003792 Walker B motif; other site 530564003793 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 530564003794 Walker A motif; other site 530564003795 ATP binding site [chemical binding]; other site 530564003796 Walker B motif; other site 530564003797 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 530564003798 Recombination protein O N terminal; Region: RecO_N; pfam11967 530564003799 Recombination protein O C terminal; Region: RecO_C; pfam02565 530564003800 outer membrane assembly lipoprotein YfiO; Region: OM_YfiO; TIGR03302 530564003801 Lipopolysaccharide-assembly; Region: LptE; cl01125 530564003802 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 530564003803 dihydropteroate synthase; Region: DHPS; TIGR01496 530564003804 substrate binding pocket [chemical binding]; other site 530564003805 dimer interface [polypeptide binding]; other site 530564003806 inhibitor binding site; inhibition site 530564003807 Uncharacterized protein related to glutamine synthetase [General function prediction only]; Region: COG3968 530564003808 Glutamine synthetase type III N terminal; Region: GSIII_N; pfam12437 530564003809 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 530564003810 glutamine synthetase, type I; Region: GlnA; TIGR00653 530564003811 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 530564003812 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 530564003813 Demethylmenaquinone methyltransferase; Region: Methyltransf_6; cl00480 530564003814 Predicted hydrolases or acyltransferases (alpha/beta hydrolase superfamily) [General function prediction only]; Region: MhpC; COG0596 530564003815 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 530564003816 phosphoglucosamine mutase; Region: Arch_GlmM; TIGR03990 530564003817 The alpha-D-phosphohexomutase superfamily includes several related enzymes that catalyze a reversible intramolecular phosphoryl transfer on their sugar substrates. Members of this family include the phosphoglucomutases (PGM1 and PGM2), phosphoglucosamine...; Region: phosphohexomutase; cl03757 530564003818 active site 530564003819 substrate binding site [chemical binding]; other site 530564003820 metal binding site [ion binding]; metal-binding site 530564003821 Zinc dependent phospholipase C/S1-P1 nuclease; Region: ZnPC_S1P1; cd10981 530564003822 Zn binding site [ion binding]; other site 530564003823 Domain of unknown function (DUF4332); Region: DUF4332; pfam14229 530564003824 trigger factor; Region: tig; TIGR00115 530564003825 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 530564003826 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 530564003827 Clp protease; Region: CLP_protease; pfam00574 530564003828 oligomer interface [polypeptide binding]; other site 530564003829 active site residues [active] 530564003830 Clp protease; Region: CLP_protease; pfam00574 530564003831 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 530564003832 oligomer interface [polypeptide binding]; other site 530564003833 active site residues [active] 530564003834 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 530564003835 phosphonate utilization associated transcriptional regulator; Region: phnR_burk; TIGR03338 530564003836 DNA-binding site [nucleotide binding]; DNA binding site 530564003837 FCD domain; Region: FCD; pfam07729 530564003838 Protein of unknown function (DUF971); Region: DUF971; pfam06155 530564003839 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 530564003840 FAD binding site [chemical binding]; other site 530564003841 Domain of unknown function (DUF4340); Region: DUF4340; pfam14238 530564003842 gliding motility-associated ABC transporter permease protein GldF; Region: ABC_perm_GldF; TIGR03518 530564003843 ABC-2 family transporter protein; Region: ABC2_membrane_4; pfam12730 530564003844 ABC-type uncharacterized transport system; Region: ABC_transp_aux; pfam09822 530564003845 Tumour suppressor, Mitostatin; Region: Trichoplein; pfam13868 530564003846 gallidermin-class lantibiotic protection ABC transporter, ATP-binding subunit; Region: galliderm_ABC; TIGR03740 530564003847 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 530564003848 Walker A/P-loop; other site 530564003849 ATP binding site [chemical binding]; other site 530564003850 Q-loop/lid; other site 530564003851 ABC transporter signature motif; other site 530564003852 Walker B; other site 530564003853 D-loop; other site 530564003854 H-loop/switch region; other site 530564003855 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 530564003856 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 530564003857 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 530564003858 dimer interface [polypeptide binding]; other site 530564003859 pyridoxal 5'-phosphate binding site [chemical binding]; other site 530564003860 catalytic residue [active] 530564003861 Tudor-like domain present in plant sequences; Region: Agenet; smart00743 530564003862 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 530564003863 NHL repeat; Region: NHL; pfam01436 530564003864 StaR_like; a well-conserved protein found in bacteria, plants, and animals. A family member from Streptomyces toyocaensis, StaR is part of a gene cluster involved in the biosynthesis of glycopeptide antibiotics (GPAs), specifically A47934. It has been...; Region: StaR_like; cd05804 530564003865 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 530564003866 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 530564003867 catalytic residues [active] 530564003868 Mg2+ transporter (mgtE); Region: mgtE; TIGR00400 530564003869 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 530564003870 Divalent cation transporter; Region: MgtE; cl00786 530564003871 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 530564003872 ATP binding site [chemical binding]; other site 530564003873 putative Mg++ binding site [ion binding]; other site 530564003874 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 530564003875 nucleotide binding region [chemical binding]; other site 530564003876 ATP-binding site [chemical binding]; other site 530564003877 GxxExxY protein; Region: GxxExxY; TIGR04256 530564003878 acetolactate synthase; Region: PLN02470 530564003879 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 530564003880 PYR/PP interface [polypeptide binding]; other site 530564003881 dimer interface [polypeptide binding]; other site 530564003882 TPP binding site [chemical binding]; other site 530564003883 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 530564003884 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 530564003885 TPP-binding site [chemical binding]; other site 530564003886 dimer interface [polypeptide binding]; other site 530564003887 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 530564003888 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 530564003889 galactarate dehydratase; Region: galactar-dH20; TIGR03248 530564003890 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 530564003891 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 530564003892 nucleoside/Zn binding site; other site 530564003893 dimer interface [polypeptide binding]; other site 530564003894 catalytic motif [active] 530564003895 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 530564003896 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 530564003897 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 530564003898 DNA binding residues [nucleotide binding] 530564003899 Major Facilitator Superfamily; Region: MFS_1; pfam07690 530564003900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 530564003901 Methylase involved in ubiquinone/menaquinone biosynthesis [Coenzyme metabolism]; Region: UbiE; COG2226 530564003902 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 530564003903 S-adenosylmethionine binding site [chemical binding]; other site 530564003904 aromatic acid decarboxylase; Validated; Region: PRK05920 530564003905 Flavoprotein; Region: Flavoprotein; pfam02441 530564003906 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 530564003907 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 530564003908 active site 530564003909 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 530564003910 active site 530564003911 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 530564003912 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 530564003913 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 530564003914 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 530564003915 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK08651 530564003916 Peptidase M20 acetylornithine deacetylase/succinyl-diaminopimelate desuccinylase (ArgE/DapE)-like; Region: M20_ArgE_DapE_like; cd08659 530564003917 metal binding site [ion binding]; metal-binding site 530564003918 dimer interface [polypeptide binding]; other site 530564003919 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 530564003920 Catalytic domain of Protein Kinases; Region: PKc; cd00180 530564003921 active site 530564003922 ATP binding site [chemical binding]; other site 530564003923 substrate binding site [chemical binding]; other site 530564003924 activation loop (A-loop); other site 530564003925 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 530564003926 FOG: WD40 repeat [General function prediction only]; Region: COG2319 530564003927 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 530564003928 structural tetrad; other site 530564003929 FOG: WD40 repeat [General function prediction only]; Region: COG2319 530564003930 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 530564003931 structural tetrad; other site 530564003932 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 530564003933 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 530564003934 Peptidase family M50; Region: Peptidase_M50; pfam02163 530564003935 active site 530564003936 putative substrate binding region [chemical binding]; other site 530564003937 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 530564003938 HlyD family secretion protein; Region: HlyD_3; pfam13437 530564003939 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 530564003940 HlyD family secretion protein; Region: HlyD_3; pfam13437 530564003941 GAF domain; Region: GAF; pfam01590 530564003942 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 530564003943 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 530564003944 Outer membrane efflux protein; Region: OEP; pfam02321 530564003945 Outer membrane efflux protein; Region: OEP; pfam02321 530564003946 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564003947 TPR repeat; Region: TPR_11; pfam13414 530564003948 binding surface 530564003949 TPR motif; other site 530564003950 TPR repeat; Region: TPR_11; pfam13414 530564003951 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564003952 binding surface 530564003953 TPR motif; other site 530564003954 Predicted methyltransferase (contains TPR repeat) [General function prediction only]; Region: COG4976 530564003955 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 530564003956 S-adenosylmethionine binding site [chemical binding]; other site 530564003957 Protein of unknown function (DUF770); Region: DUF770; cl01402 530564003958 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 530564003959 Protein of unknown function (DUF877); Region: DUF877; pfam05943 530564003960 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 530564003961 S-adenosylmethionine binding site [chemical binding]; other site 530564003962 PAAR motif; Region: PAAR_motif; pfam05488 530564003963 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 530564003964 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 530564003965 metal ion-dependent adhesion site (MIDAS); other site 530564003966 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 530564003967 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 530564003968 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 530564003969 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 530564003970 phosphopeptide binding site; other site 530564003971 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 530564003972 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 530564003973 active site 530564003974 ATP binding site [chemical binding]; other site 530564003975 substrate binding site [chemical binding]; other site 530564003976 activation loop (A-loop); other site 530564003977 Ion transport protein; Region: Ion_trans; pfam00520 530564003978 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 530564003979 Old yellow enzyme (OYE) YqjM-like FMN binding domain. YqjM is involved in the oxidative stress response of Bacillus subtilis. Like the other OYE members, each monomer of YqjM contains FMN as a non-covalently bound cofactor and uses NADPH as a reducing...; Region: OYE_YqiM_FMN; cd02932 530564003980 active site 530564003981 FMN binding site [chemical binding]; other site 530564003982 substrate binding site [chemical binding]; other site 530564003983 homotetramer interface [polypeptide binding]; other site 530564003984 catalytic residue [active] 530564003985 Protein of unknown function DUF72; Region: DUF72; pfam01904 530564003986 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 530564003987 motif II; other site 530564003988 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 530564003989 Sulfatase; Region: Sulfatase; pfam00884 530564003990 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 530564003991 Sulfatase; Region: Sulfatase; pfam00884 530564003992 Outer membrane protein transport protein (OMPP1/FadL/TodX); Region: Toluene_X; cl17479 530564003993 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; pfam09850 530564003994 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522; cl01406 530564003995 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 530564003996 type VI secretion-associated protein, ImpA family; Region: VI_chp_8; TIGR03363 530564003997 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 530564003998 Protein of unknown function (DUF770); Region: DUF770; pfam05591 530564003999 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 530564004000 Protein of unknown function (DUF877); Region: DUF877; pfam05943 530564004001 Protein of unknown function (DUF796); Region: DUF796; pfam05638 530564004002 Protein of avirulence locus involved in temperature-dependent protein secretion [General function prediction only]; Region: ImpE; COG4455 530564004003 ImpE protein; Region: ImpE; pfam07024 530564004004 Gene 25-like lysozyme; Region: GPW_gp25; cl01403 530564004005 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 530564004006 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 530564004007 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 530564004008 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 530564004009 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564004010 Walker A motif; other site 530564004011 ATP binding site [chemical binding]; other site 530564004012 Walker B motif; other site 530564004013 arginine finger; other site 530564004014 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564004015 Walker A motif; other site 530564004016 ATP binding site [chemical binding]; other site 530564004017 Walker B motif; other site 530564004018 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 530564004019 reticulocyte binding/rhoptry protein; Region: 235kDa-fam; TIGR01612 530564004020 Protein of unknown function (DUF4240); Region: DUF4240; pfam14024 530564004021 CorA-like Mg2+ transporter protein; Region: CorA; pfam01544 530564004022 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 530564004023 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 530564004024 active site 530564004025 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 530564004026 S-adenosylmethionine binding site [chemical binding]; other site 530564004027 Protein of unknown function (DUF3419); Region: DUF3419; pfam11899 530564004028 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 530564004029 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 530564004030 HEAT repeats; Region: HEAT_2; pfam13646 530564004031 Domain of unknown function (DUF1338); Region: DUF1338; pfam07063 530564004032 4-aminobutyrate aminotransferase; Provisional; Region: PRK05769 530564004033 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 530564004034 inhibitor-cofactor binding pocket; inhibition site 530564004035 pyridoxal 5'-phosphate binding site [chemical binding]; other site 530564004036 catalytic residue [active] 530564004037 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 530564004038 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 530564004039 NAD(P) binding site [chemical binding]; other site 530564004040 catalytic residues [active] 530564004041 arginine decarboxylase; Provisional; Region: PRK05354 530564004042 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 530564004043 dimer interface [polypeptide binding]; other site 530564004044 active site 530564004045 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 530564004046 catalytic residues [active] 530564004047 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 530564004048 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 530564004049 5,10-methylene-tetrahydrofolate dehydrogenase/Methenyl tetrahydrofolate cyclohydrolase [Coenzyme metabolism]; Region: FolD; COG0190 530564004050 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 530564004051 homodimer interface [polypeptide binding]; other site 530564004052 NADP binding site [chemical binding]; other site 530564004053 substrate binding site [chemical binding]; other site 530564004054 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 530564004055 Trp docking motif [polypeptide binding]; other site 530564004056 PQQ-like domain; Region: PQQ_2; pfam13360 530564004057 active site 530564004058 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 530564004059 Catalytic domain of Protein Kinases; Region: PKc; cd00180 530564004060 active site 530564004061 ATP binding site [chemical binding]; other site 530564004062 substrate binding site [chemical binding]; other site 530564004063 activation loop (A-loop); other site 530564004064 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 530564004065 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 530564004066 active site 530564004067 Uncharacterized conserved protein (DUF2132); Region: DUF2132; pfam09905 530564004068 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564004069 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564004070 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564004071 SEC-C motif; Region: SEC-C; pfam02810 530564004072 riboflavin biosynthesis protein RibD; Region: eubact_ribD; TIGR00326 530564004073 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 530564004074 catalytic motif [active] 530564004075 Zn binding site [ion binding]; other site 530564004076 RibD C-terminal domain; Region: RibD_C; cl17279 530564004077 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564004078 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 530564004079 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 530564004080 thiamine-phosphate pyrophosphorylase; Provisional; Region: PRK02615 530564004081 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 530564004082 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 530564004083 thiamine phosphate binding site [chemical binding]; other site 530564004084 active site 530564004085 pyrophosphate binding site [ion binding]; other site 530564004086 ATP-binding subunits of Clp protease and DnaK/DnaJ chaperones [Posttranslational modification, protein turnover, chaperones]; Region: clpA; COG0542 530564004087 Clp amino terminal domain; Region: Clp_N; pfam02861 530564004088 Clp amino terminal domain; Region: Clp_N; pfam02861 530564004089 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564004090 Walker A motif; other site 530564004091 ATP binding site [chemical binding]; other site 530564004092 Walker B motif; other site 530564004093 arginine finger; other site 530564004094 UvrB/uvrC motif; Region: UVR; pfam02151 530564004095 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564004096 Walker A motif; other site 530564004097 ATP binding site [chemical binding]; other site 530564004098 Walker B motif; other site 530564004099 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 530564004100 Bestrophin, RFP-TM, chloride channel; Region: Bestrophin; cl01544 530564004101 SnoaL-like domain; Region: SnoaL_2; pfam12680 530564004102 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 530564004103 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 530564004104 substrate binding site [chemical binding]; other site 530564004105 oxyanion hole (OAH) forming residues; other site 530564004106 trimer interface [polypeptide binding]; other site 530564004107 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 530564004108 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 530564004109 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 530564004110 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 530564004111 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 530564004112 dimer interface [polypeptide binding]; other site 530564004113 active site 530564004114 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme D-Threonine Aldolase; Region: PLPDE_III_D-TA; cd06821 530564004115 Predicted amino acid aldolase or racemase [Amino acid transport and metabolism]; Region: COG3616 530564004116 dimer interface [polypeptide binding]; other site 530564004117 active site 530564004118 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 530564004119 substrate binding site [chemical binding]; other site 530564004120 catalytic residue [active] 530564004121 Vault protein inter-alpha-trypsin domain; Region: VIT; cl02699 530564004122 marine proteobacterial sortase target protein; Region: marine_srt_targ; TIGR03788 530564004123 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 530564004124 metal ion-dependent adhesion site (MIDAS); other site 530564004125 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 530564004126 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564004127 binding surface 530564004128 TPR motif; other site 530564004129 Tetratricopeptide repeat; Region: TPR_16; pfam13432 530564004130 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 530564004131 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 530564004132 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cl17257 530564004133 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 530564004134 Obg family GTPase CgtA; Region: Obg_CgtA; TIGR02729 530564004135 GTP1/OBG; Region: GTP1_OBG; pfam01018 530564004136 Obg GTPase; Region: Obg; cd01898 530564004137 G1 box; other site 530564004138 GTP/Mg2+ binding site [chemical binding]; other site 530564004139 Switch I region; other site 530564004140 G2 box; other site 530564004141 G3 box; other site 530564004142 Switch II region; other site 530564004143 G4 box; other site 530564004144 G5 box; other site 530564004145 Type III pantothenate kinase; Region: Pan_kinase; pfam03309 530564004146 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cl00198 530564004147 substrate binding site [chemical binding]; other site 530564004148 hinge regions; other site 530564004149 ADP binding site [chemical binding]; other site 530564004150 catalytic site [active] 530564004151 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 530564004152 putative binding surface; other site 530564004153 active site 530564004154 Transthyretin_like. This domain is present in the transthyretin-like protein (TLP) family which includes transthyretin (TTR) and a transthyretin-related protein called 5-hydroxyisourate hydrolase (HIUase). TTR and HIUase are homotetrameric proteins...; Region: Transthyretin_like; cl17222 530564004155 Uncharacterized iron-regulated membrane protein [Function unknown]; Region: PiuB; COG3182 530564004156 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 530564004157 PepSY-associated TM helix; Region: PepSY_TM_2; pfam13703 530564004158 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564004159 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564004160 NPCBM/NEW2 domain; Region: NPCBM; cl07060 530564004161 Zn-dependent dipeptidase, microsomal dipeptidase homolog [Amino acid transport and metabolism]; Region: COG2355 530564004162 renal dipeptidase (rDP), best studied in mammals and also called membrane or microsomal dipeptidase, is a membrane-bound glycoprotein hydrolyzing dipeptides and is involved in hydrolytic metabolism of penem and carbapenem beta-lactam antibiotics; Region: rDP_like; cd01301 530564004163 active site 530564004164 dimer interface [polypeptide binding]; other site 530564004165 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 530564004166 aspartate aminotransferase; Provisional; Region: PRK06290 530564004167 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 530564004168 pyridoxal 5'-phosphate binding site [chemical binding]; other site 530564004169 homodimer interface [polypeptide binding]; other site 530564004170 catalytic residue [active] 530564004171 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 530564004172 elongation factor G; Reviewed; Region: PRK12740 530564004173 G1 box; other site 530564004174 putative GEF interaction site [polypeptide binding]; other site 530564004175 GTP/Mg2+ binding site [chemical binding]; other site 530564004176 Switch I region; other site 530564004177 G2 box; other site 530564004178 G3 box; other site 530564004179 Switch II region; other site 530564004180 G4 box; other site 530564004181 G5 box; other site 530564004182 mtEFG1_C: C-terminus of mitochondrial Elongation factor G1 (mtEFG1)-like proteins found in eukaryotes. Eukaryotic cells harbor 2 protein synthesis systems: one localized in the cytoplasm, the other in the mitochondria. Most factors regulating...; Region: mtEFG1_II_like; cd04091 530564004183 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 530564004184 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 530564004185 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 530564004186 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 530564004187 Glucose dehydrogenase; Region: glucose_DH; cd08230 530564004188 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 530564004189 NADP binding site [chemical binding]; other site 530564004190 catalytic Zn binding site [ion binding]; other site 530564004191 structural Zn binding site [ion binding]; other site 530564004192 dimer interface [polypeptide binding]; other site 530564004193 Penicillinase repressor; Region: Pencillinase_R; pfam03965 530564004194 Antirepressor regulating drug resistance, predicted signal transduction N-terminal membrane component [Transcription / Signal transduction mechanisms]; Region: MecR1; COG4219 530564004195 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 530564004196 putative catalytic site [active] 530564004197 putative metal binding site [ion binding]; other site 530564004198 putative phosphate binding site [ion binding]; other site 530564004199 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 530564004200 SnoaL-like domain; Region: SnoaL_3; pfam13474 530564004201 Bacterial alpha-L-rhamnosidase; Region: Bac_rhamnosid; pfam05592 530564004202 Alkaline and neutral invertase; Region: Glyco_hydro_100; cl17340 530564004203 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 530564004204 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 530564004205 TrkA-C domain; Region: TrkA_C; pfam02080 530564004206 TrkA-C domain; Region: TrkA_C; pfam02080 530564004207 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 530564004208 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 530564004209 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 530564004210 N-acyl-D-aspartate/D-glutamate deacylase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3653 530564004211 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 530564004212 active site 530564004213 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 530564004214 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 530564004215 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 530564004216 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 530564004217 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 530564004218 Transcription-repair coupling factor (superfamily II helicase) [DNA replication, recombination, and repair / Transcription]; Region: Mfd; COG1197 530564004219 CarD-like/TRCF domain; Region: CarD_CdnL_TRCF; pfam02559 530564004220 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 530564004221 ATP binding site [chemical binding]; other site 530564004222 putative Mg++ binding site [ion binding]; other site 530564004223 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 530564004224 nucleotide binding region [chemical binding]; other site 530564004225 ATP-binding site [chemical binding]; other site 530564004226 TRCF domain; Region: TRCF; pfam03461 530564004227 nitrogen fixation protein NifM; Region: nifM_nitrog; TIGR02933 530564004228 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 530564004229 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 530564004230 dimer interface [polypeptide binding]; other site 530564004231 Citrate synthase; Region: Citrate_synt; pfam00285 530564004232 active site 530564004233 citrylCoA binding site [chemical binding]; other site 530564004234 NADH binding [chemical binding]; other site 530564004235 cationic pore residues; other site 530564004236 oxalacetate/citrate binding site [chemical binding]; other site 530564004237 coenzyme A binding site [chemical binding]; other site 530564004238 catalytic triad [active] 530564004239 potential frameshift: common BLAST hit: gi|32474771|ref|NP_867765.1| surface-associated protein cshA precursor 530564004240 Right handed beta helix region; Region: Beta_helix; pfam13229 530564004241 VCBS repeat; Region: VCBS_repeat; TIGR01965 530564004242 Pollen proteins Ole e I like; Region: Pollen_Ole_e_I; pfam01190 530564004243 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 530564004244 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 530564004245 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 530564004246 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 530564004247 dimer interface [polypeptide binding]; other site 530564004248 conserved gate region; other site 530564004249 putative PBP binding loops; other site 530564004250 ABC-ATPase subunit interface; other site 530564004251 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 530564004252 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 530564004253 dimer interface [polypeptide binding]; other site 530564004254 conserved gate region; other site 530564004255 putative PBP binding loops; other site 530564004256 ABC-ATPase subunit interface; other site 530564004257 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 530564004258 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 530564004259 Walker A/P-loop; other site 530564004260 ATP binding site [chemical binding]; other site 530564004261 Q-loop/lid; other site 530564004262 ABC transporter signature motif; other site 530564004263 Walker B; other site 530564004264 D-loop; other site 530564004265 H-loop/switch region; other site 530564004266 TOBE domain; Region: TOBE_2; pfam08402 530564004267 ImcF-related N-terminal domain; Region: ImcF-related_N; pfam14331 530564004268 Uncharacterized protein conserved in bacteria (DUF2077); Region: DUF2077; cl01370 530564004269 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564004270 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 530564004271 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 530564004272 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 530564004273 sugar binding site [chemical binding]; other site 530564004274 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 530564004275 HEAT repeats; Region: HEAT_2; pfam13646 530564004276 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 530564004277 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 530564004278 Maf-like protein; Region: Maf; pfam02545 530564004279 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 530564004280 active site 530564004281 dimer interface [polypeptide binding]; other site 530564004282 Deacetylases, including yeast histone deacetylase and acetoin utilization protein [Chromatin structure and dynamics / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcuC; COG0123 530564004283 Histone deacetylases and histone-like deacetylases, classII; Region: HDAC_classII; cd09992 530564004284 active site 530564004285 Zn binding site [ion binding]; other site 530564004286 ATP-dependent helicase HrpA; Region: DEAH_box_HrpA; TIGR01967 530564004287 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 530564004288 ATP binding site [chemical binding]; other site 530564004289 putative Mg++ binding site [ion binding]; other site 530564004290 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 530564004291 nucleotide binding region [chemical binding]; other site 530564004292 ATP-binding site [chemical binding]; other site 530564004293 Helicase associated domain (HA2); Region: HA2; pfam04408 530564004294 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 530564004295 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 530564004296 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 530564004297 NAD(P) binding site [chemical binding]; other site 530564004298 active site 530564004299 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 530564004300 nucleotide binding site [chemical binding]; other site 530564004301 putative NEF/HSP70 interaction site [polypeptide binding]; other site 530564004302 SBD interface [polypeptide binding]; other site 530564004303 DNA-K related protein; Region: DUF3731; pfam12531 530564004304 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 530564004305 nucleotide binding site [chemical binding]; other site 530564004306 putative NEF/HSP70 interaction site [polypeptide binding]; other site 530564004307 SBD interface [polypeptide binding]; other site 530564004308 Domain of unknown function (DUF2760); Region: DUF2760; pfam10816 530564004309 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 530564004310 active site 530564004311 Protein of unknown function (DUF1551); Region: DUF1551; pfam07585 530564004312 Predicted aminomethyltransferase related to GcvT [General function prediction only]; Region: COG0354 530564004313 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 530564004314 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 530564004315 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 530564004316 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 530564004317 Platelet-activating factor acetylhydrolase, isoform II; Region: PAF-AH_p_II; pfam03403 530564004318 YTV; Region: YTV; pfam07639 530564004319 YTV; Region: YTV; pfam07639 530564004320 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 530564004321 redox-sensing transcriptional repressor Rex; Provisional; Region: PRK05472 530564004322 Putative DNA-binding protein N-terminus; Region: Put_DNA-bind_N; pfam06971 530564004323 CoA binding domain; Region: CoA_binding; smart00881 530564004324 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 530564004325 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 530564004326 DNA binding residues [nucleotide binding] 530564004327 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 530564004328 HEAT repeats; Region: HEAT_2; pfam13646 530564004329 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 530564004330 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 530564004331 FKBP-type peptidyl-prolyl cis-trans isomerases 1 [Posttranslational modification, protein turnover, chaperones]; Region: FkpA; COG0545 530564004332 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 530564004333 Family 4 Uracil-DNA glycosylase (UDG), found exclusively in thermophilic organisms; Region: UDG_F4_TTUDGA_like; cd10030 530564004334 Fe-S cluster binding site [ion binding]; other site 530564004335 active site 530564004336 ribosome-associated GTPase EngA; Region: GTPase_EngA; TIGR03594 530564004337 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 530564004338 G1 box; other site 530564004339 GTP/Mg2+ binding site [chemical binding]; other site 530564004340 Switch I region; other site 530564004341 G2 box; other site 530564004342 Switch II region; other site 530564004343 G3 box; other site 530564004344 G4 box; other site 530564004345 G5 box; other site 530564004346 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 530564004347 G1 box; other site 530564004348 GTP/Mg2+ binding site [chemical binding]; other site 530564004349 Switch I region; other site 530564004350 G2 box; other site 530564004351 G3 box; other site 530564004352 Switch II region; other site 530564004353 G4 box; other site 530564004354 G5 box; other site 530564004355 Alanine dehydrogenase [Amino acid transport and metabolism]; Region: Ald; COG0686 530564004356 Alanine dehydrogenase NAD-binding and catalytic domains; Region: L-AlaDH; cd05305 530564004357 hexamer interface [polypeptide binding]; other site 530564004358 ligand binding site [chemical binding]; other site 530564004359 putative active site [active] 530564004360 NAD(P) binding site [chemical binding]; other site 530564004361 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 530564004362 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 530564004363 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564004364 binding surface 530564004365 TPR motif; other site 530564004366 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 530564004367 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 530564004368 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 530564004369 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564004370 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564004371 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 530564004372 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 530564004373 HEAT repeats; Region: HEAT_2; pfam13646 530564004374 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 530564004375 L-fucose isomerase (FucIase) and L-arabinose isomerase (AI) family; composed of FucIase, AI and similar proteins. FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose...; Region: L-fuc_L-ara-isomerases; cl00947 530564004376 hexamer (dimer of trimers) interface [polypeptide binding]; other site 530564004377 substrate binding site [chemical binding]; other site 530564004378 trimer interface [polypeptide binding]; other site 530564004379 Mn binding site [ion binding]; other site 530564004380 Short-chain alcohol dehydrogenase of unknown specificity [General function prediction only]; Region: COG4221 530564004381 classical (c) SDRs; Region: SDR_c; cd05233 530564004382 NAD(P) binding site [chemical binding]; other site 530564004383 active site 530564004384 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4430 530564004385 Bacteriocin-protection, YdeI or OmpD-Associated; Region: OmdA; pfam13376 530564004386 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 530564004387 EamA-like transporter family; Region: EamA; pfam00892 530564004388 EamA-like transporter family; Region: EamA; pfam00892 530564004389 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 530564004390 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 530564004391 ParB-like nuclease domain; Region: ParB; smart00470 530564004392 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 530564004393 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 530564004394 P-loop; other site 530564004395 Magnesium ion binding site [ion binding]; other site 530564004396 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 530564004397 Magnesium ion binding site [ion binding]; other site 530564004398 Protein of unknown function (DUF1015); Region: DUF1015; pfam06245 530564004399 Uncharacterized conserved protein [Function unknown]; Region: COG4198 530564004400 S-adenosyl-L-homocysteine hydrolase; Provisional; Region: PRK05476 530564004401 S-Adenosylhomocysteine Hydrolase, NAD-binding and catalytic domains; Region: SAHH; cd00401 530564004402 homotetramer interface [polypeptide binding]; other site 530564004403 ligand binding site [chemical binding]; other site 530564004404 catalytic site [active] 530564004405 NAD binding site [chemical binding]; other site 530564004406 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 530564004407 active site 530564004408 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 530564004409 putative secretion ATPase, PEP-CTERM locus subfamily; Region: pepcterm_ATPase; TIGR03015 530564004410 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564004411 Walker A motif; other site 530564004412 ATP binding site [chemical binding]; other site 530564004413 Walker B motif; other site 530564004414 arginine finger; other site 530564004415 UDP-N-acetylglucosamine 4-epimerase, extended (e) SDRs; Region: UDP_AE_SDR_e; cd05256 530564004416 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 530564004417 NAD binding site [chemical binding]; other site 530564004418 substrate binding site [chemical binding]; other site 530564004419 homodimer interface [polypeptide binding]; other site 530564004420 active site 530564004421 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 530564004422 Major Facilitator Superfamily; Region: MFS_1; pfam07690 530564004423 putative substrate translocation pore; other site 530564004424 DPM1_like represents putative enzymes similar to eukaryotic DPM1; Region: DPM1_like; cd06442 530564004425 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 530564004426 Ligand binding site; other site 530564004427 Putative Catalytic site; other site 530564004428 DXD motif; other site 530564004429 cobalt transport protein CbiM; Validated; Region: PRK06265 530564004430 Cobalt uptake substrate-specific transmembrane region; Region: CbiM; pfam01891 530564004431 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 530564004432 dimer interface [polypeptide binding]; other site 530564004433 substrate binding site [chemical binding]; other site 530564004434 metal binding sites [ion binding]; metal-binding site 530564004435 UDP-N-acetyl-D-mannosaminuronate dehydrogenase [Cell envelope biogenesis, outer membrane]; Region: WecC; COG0677 530564004436 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 530564004437 UDP-glucose/GDP-mannose dehydrogenase family, UDP binding domain; Region: UDPG_MGDP_dh_C; pfam03720 530564004438 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564004439 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 530564004440 catalytic residues [active] 530564004441 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 530564004442 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_1; cd02199 530564004443 homotrimer interaction site [polypeptide binding]; other site 530564004444 putative active site [active] 530564004445 TfoX N-terminal domain; Region: TfoX_N; pfam04993 530564004446 phosphoribosyl-AMP cyclohydrolase; Reviewed; Region: hisI; PRK00051 530564004447 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 530564004448 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 530564004449 active site 530564004450 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 530564004451 Ligand binding site; other site 530564004452 Putative Catalytic site; other site 530564004453 DXD motif; other site 530564004454 nitrilase; Region: PLN02798 530564004455 Nit1, Nit 2, and related proteins, and the Nit1-like domain of NitFhit (class 10 nitrilases); Region: nit; cd07572 530564004456 putative active site [active] 530564004457 catalytic triad [active] 530564004458 dimer interface [polypeptide binding]; other site 530564004459 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 530564004460 catalytic center binding site [active] 530564004461 ATP binding site [chemical binding]; other site 530564004462 pantoate--beta-alanine ligase; Region: panC; TIGR00018 530564004463 Pantoate-beta-alanine ligase; Region: PanC; cd00560 530564004464 active site 530564004465 ATP-binding site [chemical binding]; other site 530564004466 pantoate-binding site; other site 530564004467 HXXH motif; other site 530564004468 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 530564004469 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 530564004470 Prolipoprotein diacylglyceryl transferase; Region: LGT; pfam01790 530564004471 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 530564004472 Formyltetrahydrofolate hydrolase [Nucleotide transport and metabolism]; Region: PurU; COG0788 530564004473 Formyltransferase, catalytic core domain; Region: FMT_core; cl00395 530564004474 active site 530564004475 substrate binding site [chemical binding]; other site 530564004476 cosubstrate binding site; other site 530564004477 catalytic site [active] 530564004478 Chromate transport protein ChrA [Inorganic ion transport and metabolism]; Region: ChrA; COG2059 530564004479 Chromate transporter; Region: Chromate_transp; pfam02417 530564004480 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 530564004481 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 530564004482 NAD(P) binding site [chemical binding]; other site 530564004483 active site 530564004484 bifunctional sulfate adenylyltransferase subunit 1/adenylylsulfate kinase protein; Provisional; Region: PRK05506 530564004485 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 530564004486 CysD dimerization site [polypeptide binding]; other site 530564004487 G1 box; other site 530564004488 putative GEF interaction site [polypeptide binding]; other site 530564004489 GTP/Mg2+ binding site [chemical binding]; other site 530564004490 Switch I region; other site 530564004491 G2 box; other site 530564004492 G3 box; other site 530564004493 Switch II region; other site 530564004494 G4 box; other site 530564004495 G5 box; other site 530564004496 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 530564004497 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 530564004498 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 530564004499 ligand-binding site [chemical binding]; other site 530564004500 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 530564004501 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 530564004502 Active Sites [active] 530564004503 Protein of unknown function, DUF393; Region: DUF393; pfam04134 530564004504 MAEBL; Provisional; Region: PTZ00121 530564004505 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 530564004506 PQQ-like domain; Region: PQQ_2; pfam13360 530564004507 Bacitracin resistance protein BacA; Region: BacA; pfam02673 530564004508 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 530564004509 putative exonuclease, DNA ligase-associated; Region: Xnuc_lig_assoc; TIGR04122 530564004510 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 530564004511 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 530564004512 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564004513 TPR motif; other site 530564004514 binding surface 530564004515 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 530564004516 polysaccharide export protein EpsE; Region: EpsE; TIGR03028 530564004517 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 530564004518 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 530564004519 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 530564004520 Uncharacterized small membrane protein [Function unknown]; Region: COG2363 530564004521 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 530564004522 AhpC/TSA family; Region: AhpC-TSA; pfam00578 530564004523 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 530564004524 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 530564004525 nucleotide binding pocket [chemical binding]; other site 530564004526 K-X-D-G motif; other site 530564004527 catalytic site [active] 530564004528 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 530564004529 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 530564004530 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 530564004531 Dimer interface [polypeptide binding]; other site 530564004532 Excinuclease ATPase subunit [DNA replication, recombination, and repair]; Region: UvrA; COG0178 530564004533 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 530564004534 Walker A/P-loop; other site 530564004535 ATP binding site [chemical binding]; other site 530564004536 Q-loop/lid; other site 530564004537 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 530564004538 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 530564004539 thiamine/molybdopterin biosynthesis ThiF/MoeB-like protein; Validated; Region: PRK07688 530564004540 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 530564004541 ATP binding site [chemical binding]; other site 530564004542 substrate interface [chemical binding]; other site 530564004543 Outer membrane cobalamin receptor protein [Coenzyme metabolism]; Region: BtuB; COG4206 530564004544 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 530564004545 N-terminal plug; other site 530564004546 ligand-binding site [chemical binding]; other site 530564004547 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 530564004548 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564004549 conserved repeat domain; Region: B_ant_repeat; TIGR01451 530564004550 Domain of unknown function DUF11; Region: DUF11; pfam01345 530564004551 conserved repeat domain; Region: B_ant_repeat; TIGR01451 530564004552 conserved repeat domain; Region: B_ant_repeat; TIGR01451 530564004553 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK15489 530564004554 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cl00125 530564004555 active site residue [active] 530564004556 tRNA nucleotidyltransferase/poly(A) polymerase [Translation, ribosomal structure and biogenesis]; Region: PcnB; COG0617 530564004557 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 530564004558 active site 530564004559 NTP binding site [chemical binding]; other site 530564004560 metal binding triad [ion binding]; metal-binding site 530564004561 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 530564004562 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3399 530564004563 Cna protein B-type domain; Region: Cna_B; pfam05738 530564004564 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 530564004565 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 530564004566 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 530564004567 Cna protein B-type domain; Region: Cna_B; pfam05738 530564004568 Family description; Region: VCBS; pfam13517 530564004569 Family description; Region: VCBS; pfam13517 530564004570 FOG: WD40 repeat [General function prediction only]; Region: COG2319 530564004571 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 530564004572 structural tetrad; other site 530564004573 Protein of unknown function, DUF481; Region: DUF481; pfam04338 530564004574 Protein of unknown function (DUF1551); Region: DUF1551; pfam07585 530564004575 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 530564004576 putative binding surface; other site 530564004577 active site 530564004578 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 530564004579 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 530564004580 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 530564004581 ATP binding site [chemical binding]; other site 530564004582 Mg2+ binding site [ion binding]; other site 530564004583 G-X-G motif; other site 530564004584 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 530564004585 CheW-like domain; Region: CheW; pfam01584 530564004586 Response regulator receiver domain; Region: Response_reg; pfam00072 530564004587 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564004588 active site 530564004589 phosphorylation site [posttranslational modification] 530564004590 intermolecular recognition site; other site 530564004591 dimerization interface [polypeptide binding]; other site 530564004592 Chemotaxis signal transduction protein [Cell motility and secretion / Signal transduction mechanisms]; Region: CheW; COG0835 530564004593 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 530564004594 Flp pilus assembly protein, pilin Flp [Intracellular trafficking and secretion]; Region: Flp; COG3847 530564004595 Flp pilus assembly protein, protease CpaA [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: CpaA; COG4960 530564004596 TadE-like protein; Region: TadE; pfam07811 530564004597 Flp pilus assembly protein TadG [Intracellular trafficking and secretion]; Region: TadG; COG4961 530564004598 Flp pilus assembly protein CpaB [Intracellular trafficking and secretion]; Region: CpaB; COG3745 530564004599 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 530564004600 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 530564004601 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 530564004602 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 530564004603 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564004604 Response regulator receiver domain; Region: Response_reg; pfam00072 530564004605 active site 530564004606 phosphorylation site [posttranslational modification] 530564004607 intermolecular recognition site; other site 530564004608 dimerization interface [polypeptide binding]; other site 530564004609 Flp pilus assembly protein, ATPase CpaE [Intracellular trafficking and secretion]; Region: CpaE; COG4963 530564004610 This protein family consists of proteins similar to the cpaE protein of the Caulobacter pilus assembly and the orf4 protein of Actinobacillus pilus formation gene cluster. The function of these proteins are unkown. The Caulobacter pilus assembly contains...; Region: CpaE_like; cd03111 530564004611 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 530564004612 active site 530564004613 dimerization interface [polypeptide binding]; other site 530564004614 Uncharacterized protein conserved in bacteria (DUF2237); Region: DUF2237; pfam09996 530564004615 Hsp70 protein; Region: HSP70; pfam00012 530564004616 Nucleotide-binding domain of the HSP70 family; Region: HSP70_NBD; cd10170 530564004617 nucleotide binding site [chemical binding]; other site 530564004618 putative NEF/HSP70 interaction site [polypeptide binding]; other site 530564004619 SBD interface [polypeptide binding]; other site 530564004620 Methane oxygenase PmoA; Region: PmoA; pfam14100 530564004621 Domain of unknown function (DUF1851); Region: DUF1851; pfam08906 530564004622 Global regulator protein family; Region: CsrA; pfam02599 530564004623 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564004624 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 530564004625 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 530564004626 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564004627 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564004628 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 530564004629 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 530564004630 structural tetrad; other site 530564004631 FOG: WD40 repeat [General function prediction only]; Region: COG2319 530564004632 Uncharacterized protein family UPF0047; Region: UPF0047; pfam01894 530564004633 DNA polymerase III, delta' subunit; Region: holB; TIGR00678 530564004634 AAA ATPase domain; Region: AAA_16; pfam13191 530564004635 DNA polymerase III subunit delta'; Validated; Region: PRK08485 530564004636 ATPase involved in DNA replication [DNA replication, recombination, and repair]; Region: HolB; COG0470 530564004637 thymidylate kinase; Validated; Region: tmk; PRK00698 530564004638 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 530564004639 TMP-binding site; other site 530564004640 ATP-binding site [chemical binding]; other site 530564004641 HTH domain; Region: HTH_11; cl17392 530564004642 Predicted transcriptional regulator [Transcription]; Region: COG2378 530564004643 WYL domain; Region: WYL; pfam13280 530564004644 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 530564004645 putative inner membrane protein translocase component YidC; Provisional; Region: PRK01001 530564004646 SCP: SCP-like extracellular protein domain, found in eukaryotes and prokaryotes. This family includes plant pathogenesis-related protein 1 (PR-1), which accumulates after infections with pathogens, and may act as an anti-fungal agent or be involved in...; Region: SCP; cl00133 530564004647 Domain of unknown function DUF11; Region: DUF11; pfam01345 530564004648 DNA polymerase Ligase (LigD); Region: LigD_N; pfam13298 530564004649 8-oxoguanine DNA glycosylase, N-terminal domain; Region: OGG_N; pfam07934 530564004650 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 530564004651 GcpE protein; Region: GcpE; pfam04551 530564004652 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 530564004653 bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional; Region: PRK09311 530564004654 3,4-dihydroxy-2-butanone 4-phosphate synthase; Region: DHBP_synthase; pfam00926 530564004655 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 530564004656 dimerization interface [polypeptide binding]; other site 530564004657 active site 530564004658 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564004659 Dehydrogenases (flavoproteins) [Energy production and conversion]; Region: FixC; COG0644 530564004660 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 530564004661 Sodium/hydrogen exchanger family; Region: Na_H_Exchanger; pfam00999 530564004662 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; COG0475 530564004663 dolichyl-phosphate beta-D-mannosyltransferase; Region: PLN02726 530564004664 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 530564004665 Ligand binding site; other site 530564004666 Putative Catalytic site; other site 530564004667 DXD motif; other site 530564004668 MoxR-like ATPases [General function prediction only]; Region: COG0714 530564004669 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 530564004670 Protein of unknown function (DUF1551); Region: DUF1551; pfam07585 530564004671 esterase, PHB depolymerase family; Region: esterase_phb; TIGR01840 530564004672 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564004673 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564004674 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564004675 Protein of unknown function (DUF229); Region: DUF229; pfam02995 530564004676 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 530564004677 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 530564004678 active site 530564004679 HIGH motif; other site 530564004680 dimer interface [polypeptide binding]; other site 530564004681 KMSKS motif; other site 530564004682 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 530564004683 RNA binding surface [nucleotide binding]; other site 530564004684 NHL repeat; Region: NHL; pfam01436 530564004685 NHL repeat; Region: NHL; pfam01436 530564004686 NHL repeat; Region: NHL; pfam01436 530564004687 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 530564004688 metal ion-dependent adhesion site (MIDAS); other site 530564004689 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 530564004690 von Willebrand factor type A domain; Region: VWA_2; pfam13519 530564004691 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 530564004692 MoxR-like ATPases [General function prediction only]; Region: COG0714 530564004693 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564004694 Walker A motif; other site 530564004695 ATP binding site [chemical binding]; other site 530564004696 Walker B motif; other site 530564004697 arginine finger; other site 530564004698 Protein of unknown function DUF58; Region: DUF58; pfam01882 530564004699 von Willebrand factor type A domain; Region: VWA_2; pfam13519 530564004700 metal ion-dependent adhesion site (MIDAS); other site 530564004701 Aerotolerance regulator N-terminal; Region: BatA; cl06567 530564004702 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 530564004703 metal ion-dependent adhesion site (MIDAS); other site 530564004704 phosphonoacetaldehyde hydrolase; Provisional; Region: PRK13478 530564004705 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 530564004706 motif II; other site 530564004707 virulence factor Mce family protein; Region: Mtu_fam_mce; TIGR00996 530564004708 mce related protein; Region: MCE; pfam02470 530564004709 ABC-type transport system involved in resistance to organic solvents, ATPase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2A; COG1127 530564004710 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 530564004711 Walker A/P-loop; other site 530564004712 ATP binding site [chemical binding]; other site 530564004713 Q-loop/lid; other site 530564004714 ABC transporter signature motif; other site 530564004715 Walker B; other site 530564004716 D-loop; other site 530564004717 H-loop/switch region; other site 530564004718 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 530564004719 Permease; Region: Permease; pfam02405 530564004720 Type II/IV secretion system protein; Region: T2SE; pfam00437 530564004721 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 530564004722 Walker A motif; other site 530564004723 ATP binding site [chemical binding]; other site 530564004724 Walker B motif; other site 530564004725 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 530564004726 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 530564004727 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 530564004728 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 530564004729 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 530564004730 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 530564004731 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 530564004732 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 530564004733 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564004734 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564004735 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 530564004736 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 530564004737 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 530564004738 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 530564004739 UDP-glucose LOS-beta-1,4 glucosyltransferase is required for biosynthesis of lipooligosaccharide; Region: Beta4Glucosyltransferase; cd02511 530564004740 putative metal binding site; other site 530564004741 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 530564004742 Trp docking motif [polypeptide binding]; other site 530564004743 PQQ-like domain; Region: PQQ_2; pfam13360 530564004744 active site 530564004745 5-oxoprolinase; Region: PLN02666 530564004746 Hydantoinase/oxoprolinase N-terminal region; Region: Hydant_A_N; pfam05378 530564004747 Hydantoinase/oxoprolinase; Region: Hydantoinase_A; pfam01968 530564004748 N-methylhydantoinase B/acetone carboxylase, alpha subunit [Amino acid transport and metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: HyuB; COG0146 530564004749 Type 1 glutamine amidotransferase (GATase1)-like domain found in cyanophycinase; Region: GAT1_cyanophycinase; cd03145 530564004750 proposed catalytic triad [active] 530564004751 active site nucleophile [active] 530564004752 Uncharacterized homologs of Site-2 protease (S2P), zinc metalloproteases (MEROPS family M50) which cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of the...; Region: S2P-M50_like_2; cd06160 530564004753 Peptidase family M50; Region: Peptidase_M50; pfam02163 530564004754 active site 530564004755 putative substrate binding region [chemical binding]; other site 530564004756 Uncharacterized ACR, YagE family COG1723; Region: DUF155; cl00751 530564004757 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 530564004758 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 530564004759 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 530564004760 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 530564004761 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 530564004762 DNA binding residues [nucleotide binding] 530564004763 single-stranded-DNA-specific exonuclease RecJ; Region: recJ; TIGR00644 530564004764 DHH family; Region: DHH; pfam01368 530564004765 Ribosomal protein L33; Region: Ribosomal_L33; pfam00471 530564004766 amidophosphoribosyltransferase; Region: purF; TIGR01134 530564004767 Glutamine amidotransferases class-II (GATase). The glutaminase domain catalyzes an amide nitrogen transfer from glutamine to the appropriate substrate. In this process, glutamine is hydrolyzed to glutamic acid and ammonia. This domain is related to...; Region: Gn_AT_II; cl00319 530564004768 active site 530564004769 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 530564004770 active site 530564004771 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 530564004772 NHL repeat; Region: NHL; pfam01436 530564004773 NHL repeat; Region: NHL; pfam01436 530564004774 NHL repeat; Region: NHL; pfam01436 530564004775 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cd03128 530564004776 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 530564004777 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 530564004778 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 530564004779 dimerization interface [polypeptide binding]; other site 530564004780 putative ATP binding site [chemical binding]; other site 530564004781 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 530564004782 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 530564004783 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 530564004784 protein binding site [polypeptide binding]; other site 530564004785 DnaK suppressor protein [Signal transduction mechanisms]; Region: DksA; COG1734 530564004786 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 530564004787 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 530564004788 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 530564004789 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 530564004790 active site 530564004791 trimer interface [polypeptide binding]; other site 530564004792 allosteric site; other site 530564004793 active site lid [active] 530564004794 hexamer (dimer of trimers) interface [polypeptide binding]; other site 530564004795 Pyruvate decarboxylase and related thiamine pyrophosphate-requiring enzymes [Carbohydrate transport and metabolism / Coenzyme metabolism / General function prediction only]; Region: COG3961 530564004796 Pyrimidine (PYR) binding domain of pyruvate decarboxylase (PDC), indolepyruvate decarboxylase (IPDC) and related proteins; Region: TPP_PYR_PDC_IPDC_like; cd07038 530564004797 dimer interface [polypeptide binding]; other site 530564004798 PYR/PP interface [polypeptide binding]; other site 530564004799 TPP binding site [chemical binding]; other site 530564004800 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 530564004801 Thiamine pyrophosphate (TPP) family, PDC_IPDC subfamily, TPP-binding module; composed of proteins similar to pyruvate decarboxylase (PDC) and indolepyruvate decarboxylase (IPDC). PDC, a key enzyme in alcoholic fermentation, catalyzes the conversion of...; Region: TPP_PDC_IPDC; cd02005 530564004802 TPP-binding site [chemical binding]; other site 530564004803 dimer interface [polypeptide binding]; other site 530564004804 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564004805 Tetratricopeptide repeat; Region: TPR_12; pfam13424 530564004806 binding surface 530564004807 TPR motif; other site 530564004808 Tetratricopeptide repeat; Region: TPR_12; pfam13424 530564004809 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564004810 binding surface 530564004811 TPR motif; other site 530564004812 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564004813 Sucrose-6F-phosphate phosphohydrolase; Region: S6PP; pfam05116 530564004814 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 530564004815 This family is most closely related to the GT1 family of glycosyltransferases. The sucrose-phosphate synthases in this family may be unique to plants and photosynthetic bacteria. This enzyme catalyzes the synthesis of sucrose 6-phosphate from fructose...; Region: GT1_Sucrose_synthase; cd03800 530564004816 D-inositol-3-phosphate glycosyltransferase; Region: mycothiol_MshA; TIGR03449 530564004817 putative ADP-binding pocket [chemical binding]; other site 530564004818 MarR family; Region: MarR_2; cl17246 530564004819 Transcriptional regulators [Transcription]; Region: MarR; COG1846 530564004820 histidyl-tRNA synthetase; Region: hisS; TIGR00442 530564004821 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 530564004822 dimer interface [polypeptide binding]; other site 530564004823 motif 1; other site 530564004824 active site 530564004825 motif 2; other site 530564004826 motif 3; other site 530564004827 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 530564004828 anticodon binding site; other site 530564004829 Domain of unknown function (DUF4126); Region: DUF4126; pfam13548 530564004830 Type II secretory pathway, pullulanase PulA and related glycosidases [Carbohydrate transport and metabolism]; Region: PulA; COG1523 530564004831 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 530564004832 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 530564004833 active site 530564004834 catalytic site [active] 530564004835 Predicted sugar phosphatases of the HAD superfamily [Carbohydrate transport and metabolism]; Region: NagD; COG0647 530564004836 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 530564004837 active site 530564004838 motif I; other site 530564004839 motif II; other site 530564004840 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 530564004841 Site-2 protease (S2P) class of zinc metalloproteases (MEROPS family M50) cleaves transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. Members of this family use proteolytic...; Region: S2P-M50; cl10020 530564004842 Peptidase family M50; Region: Peptidase_M50; pfam02163 530564004843 active site 530564004844 putative substrate binding region [chemical binding]; other site 530564004845 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 530564004846 HlyD family secretion protein; Region: HlyD_3; pfam13437 530564004847 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 530564004848 HlyD family secretion protein; Region: HlyD_3; pfam13437 530564004849 Membrane-fusion protein [Cell envelope biogenesis, outer membrane]; Region: AcrA; COG0845 530564004850 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 530564004851 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 530564004852 Cysteine-rich domain; Region: CCG; pfam02754 530564004853 Cysteine-rich domain; Region: CCG; pfam02754 530564004854 Domain of unknown function (DUF362); Region: DUF362; pfam04015 530564004855 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 530564004856 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 530564004857 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 530564004858 FOG: CBS domain [General function prediction only]; Region: COG0517 530564004859 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair_10; cd04623 530564004860 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 530564004861 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 530564004862 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 530564004863 catalytic residue [active] 530564004864 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 530564004865 Catalytic site [active] 530564004866 Protein of unknown function, DUF486; Region: DUF486; cl01236 530564004867 TPR repeat; Region: TPR_11; pfam13414 530564004868 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564004869 binding surface 530564004870 TPR motif; other site 530564004871 TPR repeat; Region: TPR_11; pfam13414 530564004872 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564004873 binding surface 530564004874 TPR motif; other site 530564004875 TPR repeat; Region: TPR_11; pfam13414 530564004876 Protein of unknown function (DUF1598); Region: DUF1598; pfam07643 530564004877 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564004878 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 530564004879 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564004880 F5/8 type C domain; Region: F5_F8_type_C; pfam00754 530564004881 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564004882 Transcriptional regulators [Transcription]; Region: FadR; COG2186 530564004883 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 530564004884 DNA-binding site [nucleotide binding]; DNA binding site 530564004885 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 530564004886 L-aspartate oxidase; Provisional; Region: PRK06175 530564004887 Aspartate oxidase [Coenzyme metabolism]; Region: NadB; COG0029 530564004888 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 530564004889 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 530564004890 tetramer interfaces [polypeptide binding]; other site 530564004891 binuclear metal-binding site [ion binding]; other site 530564004892 ribonuclease Y; Region: RNase_Y; TIGR03319 530564004893 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564004894 TPR motif; other site 530564004895 binding surface 530564004896 TPR repeat; Region: TPR_11; pfam13414 530564004897 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564004898 binding surface 530564004899 TPR motif; other site 530564004900 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564004901 binding surface 530564004902 TPR motif; other site 530564004903 TPR repeat; Region: TPR_11; pfam13414 530564004904 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564004905 TPR motif; other site 530564004906 binding surface 530564004907 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 530564004908 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 530564004909 active site 530564004910 catalytic triad [active] 530564004911 oxyanion hole [active] 530564004912 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 530564004913 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 530564004914 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 530564004915 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 530564004916 Peptidase family C25; Region: Peptidase_C25; pfam01364 530564004917 active site 530564004918 NHL repeat; Region: NHL; pfam01436 530564004919 NHL repeat; Region: NHL; pfam01436 530564004920 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; pfam03747 530564004921 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 530564004922 Chorismate mutase (AroH) is one of at least five chorismate-utilizing enzymes present in microorganisms that catalyze the rearrangement of chorismate to prephenic acid, the first committed step in the biosynthesis of aromatic amino acids. In prokaryotes; Region: AroH; cd02185 530564004923 homotrimer interaction site [polypeptide binding]; other site 530564004924 active site 530564004925 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 530564004926 SnoaL-like domain; Region: SnoaL_3; pfam13474 530564004927 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 530564004928 Bacterial PH domain; Region: DUF304; pfam03703 530564004929 Pyroglutamyl peptidase (PGP) type I, also known as pyrrolidone carboxyl peptidase (pcp) type I: Enzymes responsible for cleaving pyroglutamate (pGlu) from the N-terminal end of specialized proteins. The N-terminal pGlu protects these proteins from...; Region: Peptidase_C15; cd00501 530564004930 putative substrate binding pocket [chemical binding]; other site 530564004931 AC domain interface; other site 530564004932 catalytic triad [active] 530564004933 AB domain interface; other site 530564004934 interchain disulfide; other site 530564004935 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 530564004936 putative catalytic residue [active] 530564004937 Shikimate 5-dehydrogenase [Amino acid transport and metabolism]; Region: AroE; COG0169 530564004938 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 530564004939 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 530564004940 shikimate binding site; other site 530564004941 NAD(P) binding site [chemical binding]; other site 530564004942 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 530564004943 active site 530564004944 hydrophilic channel; other site 530564004945 dimerization interface [polypeptide binding]; other site 530564004946 catalytic residues [active] 530564004947 active site lid [active] 530564004948 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564004949 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 530564004950 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564004951 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564004952 Putative Ser protein kinase [Signal transduction mechanisms]; Region: PrkA; COG2766 530564004953 AAA ATPase domain; Region: AAA_16; pfam13191 530564004954 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 530564004955 hypothetical protein; Provisional; Region: PRK05325 530564004956 SpoVR like protein; Region: SpoVR; pfam04293 530564004957 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 530564004958 DEDDh 3'-5' exonuclease domain of Caenorhabditis elegans ERI-1, human 3' exonuclease, and similar proteins; Region: ERI-1_3'hExo_like; cd06133 530564004959 active site 530564004960 catalytic site [active] 530564004961 substrate binding site [chemical binding]; other site 530564004962 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 530564004963 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564004964 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 530564004965 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564004966 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564004967 Sulfatase; Region: Sulfatase; cl17466 530564004968 Uncharacterized conserved protein [Function unknown]; Region: COG1262 530564004969 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 530564004970 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 530564004971 endonuclease IV; Provisional; Region: PRK01060 530564004972 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 530564004973 AP (apurinic/apyrimidinic) site pocket; other site 530564004974 DNA interaction; other site 530564004975 Metal-binding active site; metal-binding site 530564004976 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 530564004977 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 530564004978 multiple promoter invertase; Provisional; Region: mpi; PRK13413 530564004979 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 530564004980 catalytic residues [active] 530564004981 catalytic nucleophile [active] 530564004982 Recombinase; Region: Recombinase; pfam07508 530564004983 Terminase-like family; Region: Terminase_6; pfam03237 530564004984 Uncharacterized protein conserved in bacteria (DUF2213); Region: DUF2213; pfam09979 530564004985 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 530564004986 catalytic residues [active] 530564004987 catalytic nucleophile [active] 530564004988 Recombinase; Region: Recombinase; pfam07508 530564004989 Recombinase zinc beta ribbon domain; Region: Zn_ribbon_recom; pfam13408 530564004990 Domain of unknown function (DUF4190); Region: DUF4190; pfam13828 530564004991 The SYLF domain (also called DUF500), a novel lipid-binding module; Region: SYLF; cd11524 530564004992 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_8; cd07246 530564004993 putative dimer interface [polypeptide binding]; other site 530564004994 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 530564004995 aconitate hydratase; Validated; Region: PRK09277 530564004996 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 530564004997 substrate binding site [chemical binding]; other site 530564004998 ligand binding site [chemical binding]; other site 530564004999 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 530564005000 substrate binding site [chemical binding]; other site 530564005001 signal recognition particle protein; Provisional; Region: PRK10867 530564005002 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 530564005003 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 530564005004 P loop; other site 530564005005 GTP binding site [chemical binding]; other site 530564005006 Signal peptide binding domain; Region: SRP_SPB; pfam02978 530564005007 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 530564005008 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 530564005009 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 530564005010 hypothetical protein; Reviewed; Region: PRK12497 530564005011 Predicted transcriptional regulator [Transcription]; Region: COG2378 530564005012 WYL domain; Region: WYL; pfam13280 530564005013 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 530564005014 putative active site pocket [active] 530564005015 dimerization interface [polypeptide binding]; other site 530564005016 putative catalytic residue [active] 530564005017 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 530564005018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 530564005019 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 530564005020 Walker A/P-loop; other site 530564005021 Walker A/P-loop; other site 530564005022 ATP binding site [chemical binding]; other site 530564005023 ATP binding site [chemical binding]; other site 530564005024 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 530564005025 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 530564005026 active site 530564005027 metal binding site [ion binding]; metal-binding site 530564005028 DNA binding site [nucleotide binding] 530564005029 ATP-dependent exoDNAse (exonuclease V) beta subunit (contains helicase and exonuclease domains) [DNA replication, recombination, and repair]; Region: RecB; COG1074 530564005030 Family description; Region: UvrD_C_2; pfam13538 530564005031 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 530564005032 double-strand break repair protein AddB, alphaproteobacterial type; Region: addB_alphas; TIGR02786 530564005033 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 530564005034 SurA N-terminal domain; Region: SurA_N_3; cl07813 530564005035 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 530564005036 peptidylprolyl isomerase; Provisional; Region: prsA; PRK00059 530564005037 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 530564005038 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 530564005039 active site 530564005040 catalytic triad [active] 530564005041 oxyanion hole [active] 530564005042 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 530564005043 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 530564005044 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 530564005045 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 530564005046 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 530564005047 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 530564005048 Trk-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: TrkG; COG0168 530564005049 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 530564005050 K+ transport systems, NAD-binding component [Inorganic ion transport and metabolism]; Region: TrkA; COG0569 530564005051 TrkA-N domain; Region: TrkA_N; pfam02254 530564005052 TrkA-C domain; Region: TrkA_C; pfam02080 530564005053 NPCBM/NEW2 domain; Region: NPCBM; cl07060 530564005054 NPCBM/NEW2 domain; Region: NPCBM; cl07060 530564005055 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 530564005056 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 530564005057 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 530564005058 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 530564005059 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 530564005060 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 530564005061 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 530564005062 Alpha amylase catalytic domain found in an uncharacterized protein family; Region: AmyAc_1; cd11347 530564005063 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 530564005064 active site 530564005065 catalytic site [active] 530564005066 Mannosyl oligosaccharide glucosidase; Region: Glyco_hydro_63; pfam03200 530564005067 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 530564005068 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 530564005069 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564005070 Tetratricopeptide repeat; Region: TPR_16; pfam13432 530564005071 binding surface 530564005072 TPR motif; other site 530564005073 Gemmata obscuriglobus paralogous family TIGR03066; Region: Gem_osc_para_1 530564005074 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 530564005075 PGAP1-like protein; Region: PGAP1; pfam07819 530564005076 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 530564005077 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 530564005078 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 530564005079 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 530564005080 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 530564005081 active site 530564005082 substrate-binding site [chemical binding]; other site 530564005083 metal-binding site [ion binding] 530564005084 ATP binding site [chemical binding]; other site 530564005085 BON domain; Region: BON; pfam04972 530564005086 The substrate-binding component of the oligopeptide-binding protein, AppA, from Bacillus subtilis contains the type 2 periplasmic-binding fold; Region: PBP2_AppA_like; cd08514 530564005087 peptide binding site [polypeptide binding]; other site 530564005088 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 530564005089 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 530564005090 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 530564005091 dimer interface [polypeptide binding]; other site 530564005092 conserved gate region; other site 530564005093 putative PBP binding loops; other site 530564005094 ABC-ATPase subunit interface; other site 530564005095 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 530564005096 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4239 530564005097 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 530564005098 dimer interface [polypeptide binding]; other site 530564005099 conserved gate region; other site 530564005100 putative PBP binding loops; other site 530564005101 ABC-ATPase subunit interface; other site 530564005102 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 530564005103 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 530564005104 Walker A/P-loop; other site 530564005105 ATP binding site [chemical binding]; other site 530564005106 Q-loop/lid; other site 530564005107 ABC transporter signature motif; other site 530564005108 Walker B; other site 530564005109 D-loop; other site 530564005110 H-loop/switch region; other site 530564005111 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 530564005112 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 530564005113 Walker A/P-loop; other site 530564005114 ATP binding site [chemical binding]; other site 530564005115 Q-loop/lid; other site 530564005116 ABC transporter signature motif; other site 530564005117 Walker B; other site 530564005118 D-loop; other site 530564005119 H-loop/switch region; other site 530564005120 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 530564005121 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 530564005122 active site 530564005123 metal binding site [ion binding]; metal-binding site 530564005124 homotetramer interface [polypeptide binding]; other site 530564005125 YCII-related domain; Region: YCII; cl00999 530564005126 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 530564005127 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 530564005128 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 530564005129 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 530564005130 putative hydrophobic ligand binding site [chemical binding]; other site 530564005131 4Fe-4S single cluster domain; Region: Fer4_13; pfam13370 530564005132 Probable polygalacturonase At3g15720; Region: PLN03003; cl14103 530564005133 Pectate lyase superfamily protein; Region: Pectate_lyase_3; pfam12708 530564005134 Right handed beta helix region; Region: Beta_helix; pfam13229 530564005135 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 530564005136 active site 530564005137 dimer interfaces [polypeptide binding]; other site 530564005138 catalytic residues [active] 530564005139 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 530564005140 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 530564005141 HEAT repeats; Region: HEAT_2; pfam13646 530564005142 HEAT repeats; Region: HEAT_2; pfam13646 530564005143 FOG: HEAT repeat [Energy production and conversion]; Region: COG1413 530564005144 HEAT repeats; Region: HEAT_2; pfam13646 530564005145 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 530564005146 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 530564005147 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 530564005148 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE3; Region: PHP_PolIIIA_DnaE3; cd12113 530564005149 active site 530564005150 PHP Thumb interface [polypeptide binding]; other site 530564005151 metal binding site [ion binding]; metal-binding site 530564005152 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 530564005153 generic binding surface II; other site 530564005154 generic binding surface I; other site 530564005155 Putative addiction module component; Region: Unstab_antitox; pfam09720 530564005156 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 530564005157 classical (c) SDRs; Region: SDR_c; cd05233 530564005158 NAD(P) binding site [chemical binding]; other site 530564005159 active site 530564005160 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 530564005161 Protein of unknown function DUF58; Region: DUF58; pfam01882 530564005162 von Willebrand factor type A domain; Region: VWA_2; pfam13519 530564005163 MoxR-like ATPases [General function prediction only]; Region: COG0714 530564005164 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564005165 Walker A motif; other site 530564005166 ATP binding site [chemical binding]; other site 530564005167 Walker B motif; other site 530564005168 arginine finger; other site 530564005169 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 530564005170 metal ion-dependent adhesion site (MIDAS); other site 530564005171 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 530564005172 MG2 domain; Region: A2M_N; pfam01835 530564005173 Aerotolerance regulator N-terminal; Region: BatA; cl06567 530564005174 von Willebrand factor type A domain; Region: VWA_2; pfam13519 530564005175 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 530564005176 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 530564005177 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 530564005178 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 530564005179 PQQ-like domain; Region: PQQ_2; pfam13360 530564005180 Trp docking motif [polypeptide binding]; other site 530564005181 active site 530564005182 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 530564005183 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 530564005184 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 530564005185 DNA binding residues [nucleotide binding] 530564005186 Family of unknown function (DUF1028); Region: DUF1028; pfam06267 530564005187 putative anti-sigmaE protein; Provisional; Region: PRK13920 530564005188 RNA polymerase sigma factor; Provisional; Region: PRK11924 530564005189 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 530564005190 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 530564005191 DNA binding residues [nucleotide binding] 530564005192 Methyltransferase domain; Region: Methyltransf_23; pfam13489 530564005193 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 530564005194 S-adenosylmethionine binding site [chemical binding]; other site 530564005195 3-isopropylmalate dehydrogenase; Provisional; Region: PRK03437 530564005196 tartrate dehydrogenase; Region: TTC; TIGR02089 530564005197 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 530564005198 classical (c) SDRs; Region: SDR_c; cd05233 530564005199 NAD(P) binding site [chemical binding]; other site 530564005200 active site 530564005201 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 530564005202 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 530564005203 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 530564005204 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 530564005205 Neutral/alkaline non-lysosomal ceramidase; Region: Ceramidase_alk; cl04712 530564005206 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 530564005207 homodecamer interface [polypeptide binding]; other site 530564005208 GTP cyclohydrolase I; Provisional; Region: PLN03044 530564005209 active site 530564005210 putative catalytic site residues [active] 530564005211 zinc binding site [ion binding]; other site 530564005212 GTP-CH-I/GFRP interaction surface; other site 530564005213 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 530564005214 FAD binding domain; Region: FAD_binding_4; pfam01565 530564005215 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 530564005216 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 530564005217 MoaE interaction surface [polypeptide binding]; other site 530564005218 MoeB interaction surface [polypeptide binding]; other site 530564005219 thiocarboxylated glycine; other site 530564005220 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 530564005221 MoaE homodimer interface [polypeptide binding]; other site 530564005222 MoaD interaction [polypeptide binding]; other site 530564005223 active site residues [active] 530564005224 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 530564005225 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 530564005226 FeS/SAM binding site; other site 530564005227 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 530564005228 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 530564005229 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 530564005230 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 530564005231 catalytic residue [active] 530564005232 Family description; Region: VCBS; pfam13517 530564005233 Family description; Region: VCBS; pfam13517 530564005234 Family description; Region: VCBS; pfam13517 530564005235 Family description; Region: VCBS; pfam13517 530564005236 Family description; Region: VCBS; pfam13517 530564005237 FOG: CBS domain [General function prediction only]; Region: COG0517 530564005238 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cl15354 530564005239 FOG: CBS domain [General function prediction only]; Region: COG0517 530564005240 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 530564005241 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 530564005242 Ligand-binding SRPBCC domain of an uncharacterized subfamily of proteins; Region: SRPBCC_3; cd07820 530564005243 putative hydrophobic ligand binding site [chemical binding]; other site 530564005244 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 530564005245 TIGR01777 family protein; Region: yfcH 530564005246 putative NAD(P) binding site [chemical binding]; other site 530564005247 putative active site [active] 530564005248 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564005249 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564005250 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 530564005251 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 530564005252 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564005253 AMP-binding domain protein; Validated; Region: PRK08315 530564005254 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 530564005255 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_2; cd05917 530564005256 acyl-activating enzyme (AAE) consensus motif; other site 530564005257 putative AMP binding site [chemical binding]; other site 530564005258 putative active site [active] 530564005259 putative CoA binding site [chemical binding]; other site 530564005260 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 530564005261 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 530564005262 Predicted amidophosphoribosyltransferases [General function prediction only]; Region: ComFC; COG1040 530564005263 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 530564005264 active site 530564005265 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 530564005266 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 530564005267 domain interfaces; other site 530564005268 active site 530564005269 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgG; COG4786 530564005270 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 530564005271 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 530564005272 flagellar basal-body rod protein FlgG, Gram-negative bacteria; Region: flgG_G_neg; TIGR02488 530564005273 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 530564005274 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 530564005275 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 530564005276 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 530564005277 Flagellar L-ring protein; Region: FlgH; cl17277 530564005278 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 530564005279 Flagellar P-ring protein; Region: FlgI; pfam02119 530564005280 Rod binding protein; Region: Rod-binding; pfam10135 530564005281 FlgN protein; Region: FlgN; pfam05130 530564005282 Flagellar hook-associated protein [Cell motility and secretion]; Region: FlgK; COG1256 530564005283 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 530564005284 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 530564005285 flagellar hook-associated protein FlgL; Validated; Region: flgL; PRK07701 530564005286 FliW protein; Region: FliW; cl00740 530564005287 Global regulator protein family; Region: CsrA; pfam02599 530564005288 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 530564005289 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 530564005290 Flagellin and related hook-associated proteins [Cell motility and secretion]; Region: FlgL; COG1344 530564005291 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 530564005292 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 530564005293 Flagellar capping protein [Cell motility and secretion]; Region: FliD; COG1345 530564005294 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 530564005295 Flagellar protein FliS; Region: FliS; cl00654 530564005296 Predicted periplasmic solute-binding protein [General function prediction only]; Region: COG2107 530564005297 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 530564005298 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 530564005299 putative catalytic residue [active] 530564005300 quinolinate synthetase; Provisional; Region: PRK09375 530564005301 Cytochrome oxidase complex assembly protein 1; Region: Coa1; pfam08695 530564005302 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564005303 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564005304 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 530564005305 FOG: WD40 repeat [General function prediction only]; Region: COG2319 530564005306 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 530564005307 structural tetrad; other site 530564005308 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 530564005309 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564005310 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564005311 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564005312 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 530564005313 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 530564005314 cobalamin binding residues [chemical binding]; other site 530564005315 putative BtuC binding residues; other site 530564005316 dimer interface [polypeptide binding]; other site 530564005317 ABC-type transport system involved in multi-copper enzyme maturation, permease component [General function prediction only]; Region: NosY; COG1277 530564005318 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 530564005319 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 530564005320 Walker A/P-loop; other site 530564005321 ATP binding site [chemical binding]; other site 530564005322 Q-loop/lid; other site 530564005323 ABC transporter signature motif; other site 530564005324 Walker B; other site 530564005325 D-loop; other site 530564005326 H-loop/switch region; other site 530564005327 Folylpolyglutamate synthase [Coenzyme metabolism]; Region: FolC; COG0285 530564005328 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 530564005329 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 530564005330 Fe2+ transport system protein B [Inorganic ion transport and metabolism]; Region: FeoB; COG0370 530564005331 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 530564005332 G1 box; other site 530564005333 GTP/Mg2+ binding site [chemical binding]; other site 530564005334 Switch I region; other site 530564005335 G2 box; other site 530564005336 G3 box; other site 530564005337 Switch II region; other site 530564005338 G4 box; other site 530564005339 G5 box; other site 530564005340 Nucleoside recognition; Region: Gate; pfam07670 530564005341 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 530564005342 Nucleoside recognition; Region: Gate; pfam07670 530564005343 Fe2+ transport system protein A [Inorganic ion transport and metabolism]; Region: FeoA; COG1918 530564005344 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 530564005345 Amidase; Region: Amidase; cl11426 530564005346 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 530564005347 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 530564005348 ALDH subfamily: ALDH families 1and 2, including 10-formyltetrahydrofolate dehydrogenase, NAD+-dependent retinal dehydrogenase 1 and related proteins; Region: ALDH_F1-2_Ald2-like; cd07091 530564005349 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 530564005350 NAD(P) binding site [chemical binding]; other site 530564005351 catalytic residues [active] 530564005352 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 530564005353 Trp docking motif [polypeptide binding]; other site 530564005354 active site 530564005355 PQQ-like domain; Region: PQQ_2; pfam13360 530564005356 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 530564005357 FeS/SAM binding site; other site 530564005358 translation elongation factor P; Region: efp; TIGR00038 530564005359 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 530564005360 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 530564005361 RNA binding site [nucleotide binding]; other site 530564005362 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 530564005363 RNA binding site [nucleotide binding]; other site 530564005364 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 530564005365 EF-P lysine aminoacylase GenX; Region: genX; TIGR00462 530564005366 motif 1; other site 530564005367 dimer interface [polypeptide binding]; other site 530564005368 active site 530564005369 motif 2; other site 530564005370 motif 3; other site 530564005371 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 530564005372 16S rRNA methyltransferase GidB; Reviewed; Region: gidB; PRK00107 530564005373 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 530564005374 seryl-tRNA synthetase; Provisional; Region: PRK05431 530564005375 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 530564005376 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 530564005377 dimer interface [polypeptide binding]; other site 530564005378 active site 530564005379 motif 1; other site 530564005380 motif 2; other site 530564005381 motif 3; other site 530564005382 hypothetical protein; Provisional; Region: PRK08201 530564005383 Uncharacterized M20 Dipeptidases; Region: M20_dipept_like_3; cd05680 530564005384 metal binding site [ion binding]; metal-binding site 530564005385 putative dimer interface [polypeptide binding]; other site 530564005386 ATP-dependent Clp protease adaptor protein ClpS; Region: ClpS; pfam02617 530564005387 MiaB-like tRNA modifying enzyme; Region: MiaB-like-C; TIGR01579 530564005388 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 530564005389 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 530564005390 FeS/SAM binding site; other site 530564005391 Deoxyribonuclease 1; Region: DNase1; cd10282 530564005392 putative active site [active] 530564005393 putative catalytic site [active] 530564005394 putative Mg binding site IVb [ion binding]; other site 530564005395 putative phosphate binding site [ion binding]; other site 530564005396 actin binding site [polypeptide binding]; other site 530564005397 DNA binding site [nucleotide binding] 530564005398 Ca binding site II [ion binding]; other site 530564005399 putative Mg binding site IVa [ion binding]; other site 530564005400 metal binding site III [ion binding]; metal-binding site 530564005401 Ca binding site I [ion binding]; other site 530564005402 Protein of unknown function (DUF3253); Region: DUF3253; pfam11625 530564005403 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 530564005404 S1_RPS1_repeat_ec1_hs1: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec1_hs1; cd05687 530564005405 RNA binding site [nucleotide binding]; other site 530564005406 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 530564005407 RNA binding site [nucleotide binding]; other site 530564005408 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 530564005409 RNA binding site [nucleotide binding]; other site 530564005410 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 530564005411 RNA binding site [nucleotide binding]; other site 530564005412 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 530564005413 RNA binding site [nucleotide binding]; other site 530564005414 Ribosomal protein S1-like RNA-binding domain; Region: S1; smart00316 530564005415 RNA binding site [nucleotide binding]; other site 530564005416 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 530564005417 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 530564005418 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 530564005419 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 530564005420 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 530564005421 DNA binding residues [nucleotide binding] 530564005422 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 530564005423 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_9; cd07245 530564005424 dimer interface [polypeptide binding]; other site 530564005425 putative metal binding site [ion binding]; other site 530564005426 TPR repeat; Region: TPR_11; pfam13414 530564005427 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564005428 binding surface 530564005429 TPR motif; other site 530564005430 TPR repeat; Region: TPR_11; pfam13414 530564005431 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 530564005432 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 530564005433 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 530564005434 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 530564005435 putative acyl-acceptor binding pocket; other site 530564005436 Cytidylyltransferase family; Region: CTP_transf_1; cl17467 530564005437 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 530564005438 Cytidylyltransferase family; Region: CTP_transf_1; cl17467 530564005439 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 530564005440 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 530564005441 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 530564005442 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 530564005443 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 530564005444 ABC transporter; Region: ABC_tran_2; pfam12848 530564005445 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 530564005446 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 530564005447 EPSP synthase domain. 3-phosphoshikimate 1-carboxyvinyltransferase (5-enolpyruvylshikimate-3-phosphate synthase) (EC 2.5.1.19) catalyses the reaction between shikimate-3-phosphate (S3P) and phosphoenolpyruvate (PEP) to form...; Region: EPSP_synthase; cd01556 530564005448 hinge; other site 530564005449 active site 530564005450 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 530564005451 Trp docking motif [polypeptide binding]; other site 530564005452 PQQ-like domain; Region: PQQ_2; pfam13360 530564005453 active site 530564005454 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 530564005455 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 530564005456 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 530564005457 RNA binding surface [nucleotide binding]; other site 530564005458 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 530564005459 active site 530564005460 PAF_acetylhydrolase (PAF-AH)_like subfamily of SGNH-hydrolases. Platelet-activating factor (PAF) and PAF-AH are key players in inflammation and in atherosclerosis. PAF-AH is a calcium independent phospholipase A2 which exhibits strong substrate...; Region: PAF_acetylesterase_like; cd01820 530564005461 active site 530564005462 catalytic triad [active] 530564005463 oxyanion hole [active] 530564005464 specificity pocket; other site 530564005465 HDOD domain; Region: HDOD; pfam08668 530564005466 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 530564005467 active site 530564005468 phosphorylation site [posttranslational modification] 530564005469 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 530564005470 dimerization domain swap beta strand [polypeptide binding]; other site 530564005471 regulatory protein interface [polypeptide binding]; other site 530564005472 active site 530564005473 regulatory phosphorylation site [posttranslational modification]; other site 530564005474 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 530564005475 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 530564005476 homodimer interface [polypeptide binding]; other site 530564005477 oligonucleotide binding site [chemical binding]; other site 530564005478 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 530564005479 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 530564005480 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564005481 active site 530564005482 phosphorylation site [posttranslational modification] 530564005483 intermolecular recognition site; other site 530564005484 dimerization interface [polypeptide binding]; other site 530564005485 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564005486 Walker A motif; other site 530564005487 ATP binding site [chemical binding]; other site 530564005488 Walker B motif; other site 530564005489 arginine finger; other site 530564005490 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 530564005491 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 530564005492 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 530564005493 dimerization interface [polypeptide binding]; other site 530564005494 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 530564005495 ATP binding site [chemical binding]; other site 530564005496 Mg2+ binding site [ion binding]; other site 530564005497 G-X-G motif; other site 530564005498 NADH dehydrogenase subunit D; Validated; Region: PRK06075 530564005499 NADH:ubiquinone oxidoreductase 49 kD subunit 7 [Energy production and conversion]; Region: NuoD; COG0649 530564005500 Respiratory-chain NADH dehydrogenase, 30 Kd subunit; Region: Complex1_30kDa; cl16917 530564005501 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 530564005502 NADH-ubiquinone/plastoquinone oxidoreductase, chain 3; Region: Oxidored_q4; cl00535 530564005503 Uncharacterized conserved protein (DUF2203); Region: DUF2203; pfam09969 530564005504 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 530564005505 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 530564005506 Global regulator protein family; Region: CsrA; pfam02599 530564005507 Uncharacterized protein conserved in archaea (DUF2120); Region: DUF2120; cl01687 530564005508 ferrochelatase; Reviewed; Region: hemH; PRK00035 530564005509 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 530564005510 C-terminal domain interface [polypeptide binding]; other site 530564005511 active site 530564005512 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 530564005513 active site 530564005514 N-terminal domain interface [polypeptide binding]; other site 530564005515 putative acyltransferase; Provisional; Region: PRK05790 530564005516 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 530564005517 dimer interface [polypeptide binding]; other site 530564005518 active site 530564005519 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 530564005520 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 530564005521 active site 530564005522 catalytic tetrad [active] 530564005523 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 530564005524 DNA-binding site [nucleotide binding]; DNA binding site 530564005525 RNA-binding motif; other site 530564005526 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 530564005527 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 530564005528 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 530564005529 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 530564005530 Tetratricopeptide repeat; Region: TPR_9; pfam13371 530564005531 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 530564005532 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 530564005533 active site 530564005534 8-oxo-dGMP binding site [chemical binding]; other site 530564005535 nudix motif; other site 530564005536 metal binding site [ion binding]; metal-binding site 530564005537 Enoyl-[acyl-carrier-protein]; Region: FabI; COG0623 530564005538 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 530564005539 NAD binding site [chemical binding]; other site 530564005540 homotetramer interface [polypeptide binding]; other site 530564005541 homodimer interface [polypeptide binding]; other site 530564005542 substrate binding site [chemical binding]; other site 530564005543 active site 530564005544 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 530564005545 GAF domain; Region: GAF; pfam01590 530564005546 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564005547 Walker A motif; other site 530564005548 ATP binding site [chemical binding]; other site 530564005549 Walker B motif; other site 530564005550 arginine finger; other site 530564005551 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 530564005552 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564005553 Tetratricopeptide repeat; Region: TPR_12; pfam13424 530564005554 binding surface 530564005555 TPR motif; other site 530564005556 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 530564005557 3-oxoadipate enol-lactonase; Region: protocat_pcaD; TIGR02427 530564005558 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 530564005559 TAP-like protein; Region: Abhydrolase_4; pfam08386 530564005560 CAAX protease self-immunity; Region: Abi; pfam02517 530564005561 Hint domain; Region: Hint_2; pfam13403 530564005562 Pretoxin HINT domain; Region: PT-HINT; pfam07591 530564005563 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 530564005564 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 530564005565 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 530564005566 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 530564005567 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 530564005568 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 530564005569 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 530564005570 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 530564005571 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 530564005572 FeS/SAM binding site; other site 530564005573 7-cyano-7-deazaguanine reductase; Provisional; Region: PRK13258 530564005574 hypothetical protein; Provisional; Region: PRK04194 530564005575 Predicted ATP-dependent carboligase related to biotin carboxylase [General function prediction only]; Region: COG2232 530564005576 ATP-grasp domain; Region: ATP-grasp_4; cl17255 530564005577 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 530564005578 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 530564005579 putative acyl-acceptor binding pocket; other site 530564005580 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_7; cd13133 530564005581 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 530564005582 EVE domain; Region: EVE; cl00728 530564005583 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 530564005584 Porphyromonas-type peptidyl-arginine deiminase; Region: PAD_porph; pfam04371 530564005585 N-carbamoylputrescine amidohydrolase (CPA) (class 11 nitrilases); Region: CPA; cd07573 530564005586 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 530564005587 putative active site; other site 530564005588 catalytic triad [active] 530564005589 putative dimer interface [polypeptide binding]; other site 530564005590 epoxyqueuosine reductase; Region: TIGR00276 530564005591 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 530564005592 HEAT repeat; Region: HEAT; pfam02985 530564005593 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 530564005594 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 530564005595 AP (apurinic/apyrimidinic) site pocket; other site 530564005596 DNA interaction; other site 530564005597 Metal-binding active site; metal-binding site 530564005598 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 530564005599 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 530564005600 Predicted membrane protein [Function unknown]; Region: COG2259 530564005601 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 530564005602 active site 530564005603 ADP/pyrophosphate binding site [chemical binding]; other site 530564005604 dimerization interface [polypeptide binding]; other site 530564005605 allosteric effector site; other site 530564005606 fructose-1,6-bisphosphate binding site; other site 530564005607 S23 ribosomal protein; Region: Ribosomal_S23p; pfam05635 530564005608 four helix bundle protein; Region: TIGR02436 530564005609 haloacid dehalogenase-like hydrolase; Region: Hydrolase; pfam00702 530564005610 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 530564005611 motif II; other site 530564005612 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 530564005613 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 530564005614 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 530564005615 gluconate 5-dehydrogenase; Provisional; Region: PRK08213 530564005616 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 530564005617 NAD(P) binding site [chemical binding]; other site 530564005618 active site 530564005619 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 530564005620 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 530564005621 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 530564005622 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 530564005623 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564005624 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 530564005625 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564005626 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 530564005627 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564005628 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 530564005629 D-allose kinase; Provisional; Region: PRK09698 530564005630 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 530564005631 putative dehydratase; Provisional; Region: PRK08211 530564005632 Dehydratase family; Region: ILVD_EDD; cl00340 530564005633 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 530564005634 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 530564005635 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 530564005636 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 530564005637 Periplasmic protein TonB, links inner and outer membranes [Cell envelope biogenesis, outer membrane]; Region: TonB; COG0810 530564005638 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 530564005639 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 530564005640 RNA/DNA hybrid binding site [nucleotide binding]; other site 530564005641 active site 530564005642 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 530564005643 Catalytic domain of Protein Kinases; Region: PKc; cd00180 530564005644 active site 530564005645 ATP binding site [chemical binding]; other site 530564005646 substrate binding site [chemical binding]; other site 530564005647 activation loop (A-loop); other site 530564005648 RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984 530564005649 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 530564005650 DNA binding residues [nucleotide binding] 530564005651 Proteins of 100 residues with WXG; Region: WXG100; pfam06013 530564005652 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 530564005653 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 530564005654 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 530564005655 Predicted nucleotidyltransferase; Region: Nuc-transf; cl01417 530564005656 TfoX C-terminal domain; Region: TfoX_C; pfam04994 530564005657 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 530564005658 active site 530564005659 catalytic triad [active] 530564005660 oxyanion hole [active] 530564005661 TPR repeat; Region: TPR_11; pfam13414 530564005662 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564005663 TPR motif; other site 530564005664 binding surface 530564005665 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 530564005666 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 530564005667 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 530564005668 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 530564005669 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 530564005670 active site 530564005671 catalytic triad [active] 530564005672 oxyanion hole [active] 530564005673 This domain superfamily is found in a variety of structurally related metalloproteins, including the type I extradiol dioxygenases, glyoxalase I and a group of antibiotic resistance proteins; Region: Glo_EDI_BRP_like; cl14632 530564005674 ATP-grasp domain; Region: ATP-grasp_4; cl17255 530564005675 Domain of unknown function (DUF303); Region: DUF303; pfam03629 530564005676 PAS fold; Region: PAS_4; pfam08448 530564005677 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 530564005678 putative active site [active] 530564005679 heme pocket [chemical binding]; other site 530564005680 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cl10029 530564005681 Helix-turn-helix domain; Region: HTH_18; pfam12833 530564005682 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 530564005683 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 530564005684 ATP cone domain; Region: ATP-cone; pfam03477 530564005685 zinc-ribbon domain; Region: zinc_ribbon_2; pfam13240 530564005686 Double zinc ribbon; Region: DZR; pfam12773 530564005687 Bacterial PH domain; Region: DUF304; pfam03703 530564005688 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 530564005689 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 530564005690 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 530564005691 recombination protein RecR; Reviewed; Region: recR; PRK00076 530564005692 RecR protein; Region: RecR; pfam02132 530564005693 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 530564005694 putative active site [active] 530564005695 putative metal-binding site [ion binding]; other site 530564005696 tetramer interface [polypeptide binding]; other site 530564005697 DNA polymerase III, subunit gamma and tau; Region: dnaX_nterm; TIGR02397 530564005698 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564005699 Walker A motif; other site 530564005700 ATP binding site [chemical binding]; other site 530564005701 Walker B motif; other site 530564005702 arginine finger; other site 530564005703 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 530564005704 Formaldehyde-activating enzyme (Fae); Region: Fae; pfam08714 530564005705 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 530564005706 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 530564005707 Zn2+ binding site [ion binding]; other site 530564005708 Mg2+ binding site [ion binding]; other site 530564005709 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 530564005710 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 530564005711 CAAX protease self-immunity; Region: Abi; pfam02517 530564005712 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 530564005713 ATP-binding cassette domain of the Na+ transporter; Region: ABC_NatA_sodium_exporter; cd03266 530564005714 Walker A/P-loop; other site 530564005715 ATP binding site [chemical binding]; other site 530564005716 Q-loop/lid; other site 530564005717 ABC transporter signature motif; other site 530564005718 Walker B; other site 530564005719 D-loop; other site 530564005720 H-loop/switch region; other site 530564005721 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 530564005722 metal-dependent hydrolase; Provisional; Region: PRK13291 530564005723 DinB superfamily; Region: DinB_2; pfam12867 530564005724 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 530564005725 PhoH-like protein; Region: PhoH; pfam02562 530564005726 Predicted membrane-associated HD superfamily hydrolase [General function prediction only]; Region: COG1480 530564005727 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 530564005728 Zn2+ binding site [ion binding]; other site 530564005729 Mg2+ binding site [ion binding]; other site 530564005730 Uncharacterized protein family UPF0054; Region: UPF0054; pfam02130 530564005731 PA14 domain; Region: PA14; cl08459 530564005732 Glucose/sorbosone dehydrogenases [Carbohydrate transport and metabolism]; Region: COG2133 530564005733 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 530564005734 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 530564005735 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 530564005736 Prenyltransferase-like; Region: Prenyltrans_1; pfam13243 530564005737 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 530564005738 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 530564005739 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 530564005740 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 530564005741 TM-ABC transporter signature motif; other site 530564005742 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 530564005743 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 530564005744 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 530564005745 Trp docking motif [polypeptide binding]; other site 530564005746 active site 530564005747 PQQ-like domain; Region: PQQ_2; pfam13360 530564005748 Predicted acetamidase/formamidase [Energy production and conversion]; Region: COG2421 530564005749 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 530564005750 Sulfatase; Region: Sulfatase; pfam00884 530564005751 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 530564005752 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 530564005753 Coenzyme A binding pocket [chemical binding]; other site 530564005754 elongation factor G; Reviewed; Region: PRK12739 530564005755 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 530564005756 G1 box; other site 530564005757 putative GEF interaction site [polypeptide binding]; other site 530564005758 GTP/Mg2+ binding site [chemical binding]; other site 530564005759 Switch I region; other site 530564005760 G2 box; other site 530564005761 G3 box; other site 530564005762 Switch II region; other site 530564005763 G4 box; other site 530564005764 G5 box; other site 530564005765 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 530564005766 Elongation Factor G-like domain IV. This family includes the translational elongation factor termed EF-2 (for Archaea and Eukarya) and EF-G (for Bacteria), ribosomal protection proteins that mediate tetracycline resistance and, an evolutionarily...; Region: EFG_like_IV; cd01680 530564005767 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 530564005768 30S ribosomal protein S7; Validated; Region: PRK05302 530564005769 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 530564005770 S17 interaction site [polypeptide binding]; other site 530564005771 S8 interaction site; other site 530564005772 16S rRNA interaction site [nucleotide binding]; other site 530564005773 streptomycin interaction site [chemical binding]; other site 530564005774 23S rRNA interaction site [nucleotide binding]; other site 530564005775 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 530564005776 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 530564005777 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 530564005778 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 530564005779 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 530564005780 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 530564005781 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 530564005782 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 530564005783 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 530564005784 Apocytochrome F, C-terminal; Region: Apocytochr_F_C; cl03168 530564005785 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 530564005786 DNA binding site [nucleotide binding] 530564005787 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 530564005788 RNA polymerase beta subunit; Region: RNA_pol_Rpb2_1; pfam04563 530564005789 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 530564005790 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 530564005791 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 530564005792 RPB11 interaction site [polypeptide binding]; other site 530564005793 RPB12 interaction site [polypeptide binding]; other site 530564005794 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 530564005795 RPB12 interaction site [polypeptide binding]; other site 530564005796 RPB3 interaction site [polypeptide binding]; other site 530564005797 RPB1 interaction site [polypeptide binding]; other site 530564005798 RPB11 interaction site [polypeptide binding]; other site 530564005799 RPB10 interaction site [polypeptide binding]; other site 530564005800 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 530564005801 core dimer interface [polypeptide binding]; other site 530564005802 peripheral dimer interface [polypeptide binding]; other site 530564005803 L10 interface [polypeptide binding]; other site 530564005804 L11 interface [polypeptide binding]; other site 530564005805 putative EF-Tu interaction site [polypeptide binding]; other site 530564005806 putative EF-G interaction site [polypeptide binding]; other site 530564005807 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 530564005808 23S rRNA interface [nucleotide binding]; other site 530564005809 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 530564005810 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 530564005811 mRNA/rRNA interface [nucleotide binding]; other site 530564005812 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 530564005813 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 530564005814 23S rRNA interface [nucleotide binding]; other site 530564005815 L7/L12 interface [polypeptide binding]; other site 530564005816 putative thiostrepton binding site; other site 530564005817 L25 interface [polypeptide binding]; other site 530564005818 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 530564005819 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 530564005820 putative homodimer interface [polypeptide binding]; other site 530564005821 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 530564005822 heterodimer interface [polypeptide binding]; other site 530564005823 homodimer interface [polypeptide binding]; other site 530564005824 preprotein translocase, SecE subunit, bacterial; Region: secE_bact; TIGR00964 530564005825 elongation factor Tu; Reviewed; Region: PRK12735 530564005826 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 530564005827 G1 box; other site 530564005828 GEF interaction site [polypeptide binding]; other site 530564005829 GTP/Mg2+ binding site [chemical binding]; other site 530564005830 Switch I region; other site 530564005831 G2 box; other site 530564005832 G3 box; other site 530564005833 Switch II region; other site 530564005834 G4 box; other site 530564005835 G5 box; other site 530564005836 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 530564005837 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 530564005838 Antibiotic Binding Site [chemical binding]; other site 530564005839 Helix-turn-helix domain; Region: HTH_17; pfam12728 530564005840 RNA polymerase sigma factor SigD; Validated; Region: PRK07405 530564005841 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 530564005842 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 530564005843 DNA binding residues [nucleotide binding] 530564005844 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 530564005845 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 530564005846 Uncharacterized conserved protein [Function unknown]; Region: COG0432 530564005847 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 530564005848 Trehalose utilisation; Region: ThuA; pfam06283 530564005849 Uncharacterized conserved protein (COG2071); Region: DUF2071; pfam09844 530564005850 Glycerophosphoryl diester phosphodiesterase [Energy production and conversion]; Region: UgpQ; COG0584 530564005851 Glycerophosphodiester phosphodiesterase domain as found in prokaryota and eukaryota, and similar proteins; Region: GDPD; cd08556 530564005852 active site 530564005853 catalytic site [active] 530564005854 metal binding site [ion binding]; metal-binding site 530564005855 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 530564005856 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 530564005857 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 530564005858 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 530564005859 catalytic residues [active] 530564005860 lysine biosynthesis protein LysW; Region: lysW; TIGR01206 530564005861 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 530564005862 Long-chain acyl-CoA synthetases (AMP-forming) [Lipid metabolism]; Region: FAA1; COG1022 530564005863 Long-chain fatty acid CoA synthetases and Bubblegum-like very long-chain fatty acid CoA synthetases; Region: VL_LC_FACS_like; cd05907 530564005864 acyl-activating enzyme (AAE) consensus motif; other site 530564005865 putative AMP binding site [chemical binding]; other site 530564005866 putative active site [active] 530564005867 putative CoA binding site [chemical binding]; other site 530564005868 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 530564005869 Acyl-CoA dehydrogenase, N-terminal domain; Region: Acyl-CoA_dh_N; pfam02771 530564005870 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 530564005871 active site 530564005872 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 530564005873 substrate binding site; other site 530564005874 dimer interface; other site 530564005875 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 530564005876 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 530564005877 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 530564005878 Low molecular weight phosphatase family; Region: LMWPc; cd00115 530564005879 active site 530564005880 Ribose/Galactose Isomerase; Region: LacAB_rpiB; pfam02502 530564005881 BON domain; Region: BON; pfam04972 530564005882 Suppressor of fused protein (SUFU); Region: SUFU; pfam05076 530564005883 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 530564005884 phosphate transport system regulatory protein PhoU; Region: phoU_full; TIGR02135 530564005885 PhoU domain; Region: PhoU; pfam01895 530564005886 PhoU domain; Region: PhoU; pfam01895 530564005887 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 530564005888 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564005889 active site 530564005890 phosphorylation site [posttranslational modification] 530564005891 intermolecular recognition site; other site 530564005892 dimerization interface [polypeptide binding]; other site 530564005893 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 530564005894 DNA binding site [nucleotide binding] 530564005895 riboflavin synthase subunit alpha; Provisional; Region: PRK09289 530564005896 Lumazine binding domain; Region: Lum_binding; pfam00677 530564005897 Lumazine binding domain; Region: Lum_binding; pfam00677 530564005898 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 530564005899 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 530564005900 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 530564005901 50S ribosomal protein L3; Validated; Region: rplC; PRK00001 530564005902 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 530564005903 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 530564005904 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 530564005905 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 530564005906 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 530564005907 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 530564005908 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 530564005909 putative translocon binding site; other site 530564005910 protein-rRNA interface [nucleotide binding]; other site 530564005911 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 530564005912 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 530564005913 G-X-X-G motif; other site 530564005914 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 530564005915 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 530564005916 23S rRNA interface [nucleotide binding]; other site 530564005917 5S rRNA interface [nucleotide binding]; other site 530564005918 putative antibiotic binding site [chemical binding]; other site 530564005919 L25 interface [polypeptide binding]; other site 530564005920 L27 interface [polypeptide binding]; other site 530564005921 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 530564005922 23S rRNA interface [nucleotide binding]; other site 530564005923 putative translocon interaction site; other site 530564005924 signal recognition particle (SRP54) interaction site; other site 530564005925 L23 interface [polypeptide binding]; other site 530564005926 trigger factor interaction site; other site 530564005927 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 530564005928 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 530564005929 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 530564005930 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 530564005931 RNA binding site [nucleotide binding]; other site 530564005932 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 530564005933 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 530564005934 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 530564005935 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08061 530564005936 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 530564005937 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 530564005938 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 530564005939 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 530564005940 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 530564005941 5S rRNA interface [nucleotide binding]; other site 530564005942 23S rRNA interface [nucleotide binding]; other site 530564005943 L5 interface [polypeptide binding]; other site 530564005944 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 530564005945 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 530564005946 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 530564005947 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 530564005948 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 530564005949 SecY translocase; Region: SecY; pfam00344 530564005950 adenylate kinase; Reviewed; Region: adk; PRK00279 530564005951 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 530564005952 AMP-binding site [chemical binding]; other site 530564005953 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 530564005954 50S ribosomal protein L36; Reviewed; Region: rpmJ; PRK00465 530564005955 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 530564005956 30S ribosomal protein S13; Region: bact_S13; TIGR03631 530564005957 30S ribosomal protein S11; Validated; Region: PRK05309 530564005958 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 530564005959 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 530564005960 alphaNTD homodimer interface [polypeptide binding]; other site 530564005961 alphaNTD - beta interaction site [polypeptide binding]; other site 530564005962 alphaNTD - beta' interaction site [polypeptide binding]; other site 530564005963 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 530564005964 Ribosomal protein L17; Region: Ribosomal_L17; pfam01196 530564005965 Predicted metallopeptidase [General function prediction only]; Region: COG4900 530564005966 Zinc ribbon domain; Region: CxxC_CxxC_SSSS; cl00993 530564005967 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 530564005968 Predicted archaeal sugar kinases [General function prediction only]; Region: COG1907 530564005969 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 530564005970 Protein of unknown function (DUF447); Region: DUF447; pfam04289 530564005971 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 530564005972 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 530564005973 glutamine binding [chemical binding]; other site 530564005974 catalytic triad [active] 530564005975 Anthranilate/para-aminobenzoate synthases component I [Amino acid transport and metabolism / Coenzyme metabolism]; Region: TrpE; COG0147 530564005976 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 530564005977 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 530564005978 dihydropteroate synthase-related protein; Region: TIGR00284 530564005979 Pterin binding enzymes. This family includes dihydropteroate synthase (DHPS) and cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). DHPS, a...; Region: Pterin_binding; cl00219 530564005980 substrate binding pocket [chemical binding]; other site 530564005981 dimer interface [polypeptide binding]; other site 530564005982 inhibitor binding site; inhibition site 530564005983 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 530564005984 classical (c) SDRs; Region: SDR_c; cd05233 530564005985 NAD(P) binding site [chemical binding]; other site 530564005986 active site 530564005987 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 530564005988 PQQ-like domain; Region: PQQ_2; pfam13360 530564005989 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 530564005990 Trp docking motif [polypeptide binding]; other site 530564005991 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 530564005992 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 530564005993 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564005994 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 530564005995 HicB family; Region: HicB; pfam05534 530564005996 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 530564005997 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 530564005998 protein binding site [polypeptide binding]; other site 530564005999 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 530564006000 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 530564006001 Walker A/P-loop; other site 530564006002 ATP binding site [chemical binding]; other site 530564006003 Q-loop/lid; other site 530564006004 ABC transporter signature motif; other site 530564006005 Walker B; other site 530564006006 D-loop; other site 530564006007 H-loop/switch region; other site 530564006008 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 530564006009 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 530564006010 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 530564006011 TM-ABC transporter signature motif; other site 530564006012 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 530564006013 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 530564006014 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 530564006015 Catalytic domain of Protein Kinases; Region: PKc; cd00180 530564006016 active site 530564006017 ATP binding site [chemical binding]; other site 530564006018 substrate binding site [chemical binding]; other site 530564006019 activation loop (A-loop); other site 530564006020 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 530564006021 Cysteine-rich domain; Region: CCG; pfam02754 530564006022 Cysteine-rich domain; Region: CCG; pfam02754 530564006023 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 530564006024 FAD binding domain; Region: FAD_binding_4; pfam01565 530564006025 FAD binding domain; Region: FAD_binding_4; pfam01565 530564006026 glycolate oxidase, subunit GlcD; Region: glcD; TIGR00387 530564006027 Predicted dehydrogenase [General function prediction only]; Region: COG0579 530564006028 hydroxyglutarate oxidase; Provisional; Region: PRK11728 530564006029 Protein of unknown function (DUF1207); Region: DUF1207; pfam06727 530564006030 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 530564006031 UGMP family protein; Validated; Region: PRK09604 530564006032 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 530564006033 metal ion-dependent adhesion site (MIDAS); other site 530564006034 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 530564006035 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 530564006036 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 530564006037 Putative amidoligase enzyme (DUF2126); Region: DUF2126; pfam09899 530564006038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4196 530564006039 formaldehyde-activating enzyme; Region: one_C_fae; TIGR03126 530564006040 Methylene-tetrahydromethanopterin dehydrogenase, N-terminal; Region: Mpt_N; pfam09176 530564006041 NADP binding domain of methylene tetrahydromethanopterin dehydrogenase; Region: NAD_bind_H4MPT_DH; cd01078 530564006042 NADP binding site [chemical binding]; other site 530564006043 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 530564006044 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 530564006045 Moco binding site; other site 530564006046 metal coordination site [ion binding]; other site 530564006047 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 530564006048 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 530564006049 Surface antigen; Region: Bac_surface_Ag; pfam01103 530564006050 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 530564006051 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 530564006052 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 530564006053 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 530564006054 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 530564006055 arginyl-tRNA-protein transferase; Provisional; Region: PRK01305 530564006056 Arginine-tRNA-protein transferase, N terminus; Region: ATE_N; pfam04376 530564006057 Arginine-tRNA-protein transferase, C terminus; Region: ATE_C; pfam04377 530564006058 replicative DNA helicase; Region: DnaB; TIGR00665 530564006059 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 530564006060 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 530564006061 Walker A motif; other site 530564006062 ATP binding site [chemical binding]; other site 530564006063 Walker B motif; other site 530564006064 DNA binding loops [nucleotide binding] 530564006065 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 530564006066 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 530564006067 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 530564006068 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 530564006069 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 530564006070 dimer interface [polypeptide binding]; other site 530564006071 ssDNA binding site [nucleotide binding]; other site 530564006072 tetramer (dimer of dimers) interface [polypeptide binding]; other site 530564006073 Ribosomal protein S6; Region: Ribosomal_S6; pfam01250 530564006074 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 530564006075 putative active site [active] 530564006076 catalytic residue [active] 530564006077 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 530564006078 ribosomal protein L25, Ctc-form; Region: ctc_TL5; TIGR00731 530564006079 5S rRNA interface [nucleotide binding]; other site 530564006080 CTC domain interface [polypeptide binding]; other site 530564006081 L16 interface [polypeptide binding]; other site 530564006082 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 530564006083 oligomerisation interface [polypeptide binding]; other site 530564006084 mobile loop; other site 530564006085 roof hairpin; other site 530564006086 ent-copalyl diphosphate synthase; Region: PLN02592 530564006087 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 530564006088 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 530564006089 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 530564006090 active site 530564006091 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 530564006092 Substrate binding site; other site 530564006093 Mg++ binding site; other site 530564006094 AAK_NAGK-C: N-Acetyl-L-glutamate kinase - cyclic (NAGK-C) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of arginine biosynthesis found in some bacteria and photosynthetic organisms using the...; Region: AAK_NAGK-C; cd04250 530564006095 feedback inhibition sensing region; other site 530564006096 homohexameric interface [polypeptide binding]; other site 530564006097 nucleotide binding site [chemical binding]; other site 530564006098 N-acetyl-L-glutamate binding site [chemical binding]; other site 530564006099 acetylornithine aminotransferase; Provisional; Region: PRK02627 530564006100 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 530564006101 inhibitor-cofactor binding pocket; inhibition site 530564006102 pyridoxal 5'-phosphate binding site [chemical binding]; other site 530564006103 catalytic residue [active] 530564006104 ornithine carbamoyltransferase; Provisional; Region: PRK00779 530564006105 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 530564006106 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 530564006107 ribonuclease PH; Reviewed; Region: rph; PRK00173 530564006108 RNase PH-like 3'-5' exoribonucleases; Region: RNase_PH; cl03114 530564006109 oligomer interface [polypeptide binding]; other site 530564006110 RNA binding site [nucleotide binding]; other site 530564006111 Sulfatase; Region: Sulfatase; cl17466 530564006112 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 530564006113 Global regulator protein family; Region: CsrA; pfam02599 530564006114 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 530564006115 Esterase/lipase [Lipid metabolism]; Region: Aes; COG0657 530564006116 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 530564006117 Mitochondrial biogenesis AIM24; Region: AIM24; pfam01987 530564006118 threonine synthase; Validated; Region: PRK08197 530564006119 Threonine synthase is a pyridoxal phosphate (PLP) dependent enzyme that catalyses the last reaction in the synthesis of threonine from aspartate. It proceeds by converting O-phospho-L-homoserine (OPH) into threonine and inorganic phosphate. In plants; Region: Thr-synth_1; cd01563 530564006120 homodimer interface [polypeptide binding]; other site 530564006121 pyridoxal 5'-phosphate binding site [chemical binding]; other site 530564006122 catalytic residue [active] 530564006123 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 530564006124 active site 530564006125 Zn-ribbon protein, possibly nucleic acid-binding [General function prediction only]; Region: COG1579 530564006126 Putative zinc ribbon domain; Region: DUF164; pfam02591 530564006127 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 530564006128 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 530564006129 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 530564006130 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 530564006131 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 530564006132 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 530564006133 DNA binding residues [nucleotide binding] 530564006134 DNA primase; Validated; Region: dnaG; PRK05667 530564006135 CHC2 zinc finger; Region: zf-CHC2; cl17510 530564006136 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 530564006137 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 530564006138 active site 530564006139 metal binding site [ion binding]; metal-binding site 530564006140 interdomain interaction site; other site 530564006141 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 530564006142 HEAT repeats; Region: HEAT_2; pfam13646 530564006143 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 530564006144 PQQ-like domain; Region: PQQ_2; pfam13360 530564006145 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 530564006146 PQQ-like domain; Region: PQQ_2; pfam13360 530564006147 Trp docking motif [polypeptide binding]; other site 530564006148 active site 530564006149 HEAT repeats; Region: HEAT_2; pfam13646 530564006150 PQQ-like domain; Region: PQQ_2; pfam13360 530564006151 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 530564006152 metal ion-dependent adhesion site (MIDAS); other site 530564006153 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 530564006154 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 530564006155 Protein of unknown function DUF58; Region: DUF58; pfam01882 530564006156 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 530564006157 metal ion-dependent adhesion site (MIDAS); other site 530564006158 MoxR-like ATPases [General function prediction only]; Region: COG0714 530564006159 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564006160 Walker A motif; other site 530564006161 ATP binding site [chemical binding]; other site 530564006162 Walker B motif; other site 530564006163 arginine finger; other site 530564006164 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 530564006165 metal ion-dependent adhesion site (MIDAS); other site 530564006166 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 530564006167 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 530564006168 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 530564006169 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 530564006170 dimerization interface [polypeptide binding]; other site 530564006171 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 530564006172 dimer interface [polypeptide binding]; other site 530564006173 phosphorylation site [posttranslational modification] 530564006174 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 530564006175 ATP binding site [chemical binding]; other site 530564006176 Mg2+ binding site [ion binding]; other site 530564006177 G-X-G motif; other site 530564006178 Molybdopterin biosynthesis enzyme [Coenzyme metabolism]; Region: MoeA; COG0303 530564006179 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 530564006180 dimer interface [polypeptide binding]; other site 530564006181 putative functional site; other site 530564006182 putative MPT binding site; other site 530564006183 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 530564006184 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 530564006185 glutamine binding [chemical binding]; other site 530564006186 catalytic triad [active] 530564006187 ATP-dependent protease La (LON) domain; Region: LON; pfam02190 530564006188 Maf-like protein; Reviewed; Region: PRK00078 530564006189 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 530564006190 active site 530564006191 dimer interface [polypeptide binding]; other site 530564006192 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 530564006193 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 530564006194 active site 530564006195 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 530564006196 Catalytic domain of Protein Kinases; Region: PKc; cd00180 530564006197 active site 530564006198 ATP binding site [chemical binding]; other site 530564006199 substrate binding site [chemical binding]; other site 530564006200 activation loop (A-loop); other site 530564006201 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 530564006202 Bacterial extracellular solute-binding proteins, family 5 Middle; Region: SBP_bac_5; pfam00496 530564006203 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 530564006204 PQQ-like domain; Region: PQQ_2; pfam13360 530564006205 PQQ-like domain; Region: PQQ_2; pfam13360 530564006206 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 530564006207 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 530564006208 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 530564006209 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 530564006210 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 530564006211 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 530564006212 HEAT repeats; Region: HEAT_2; pfam13646 530564006213 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 530564006214 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 530564006215 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 530564006216 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 530564006217 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 530564006218 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 530564006219 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 530564006220 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 530564006221 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 530564006222 protein binding site [polypeptide binding]; other site 530564006223 pyruvate carboxylase; Reviewed; Region: PRK12999 530564006224 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 530564006225 ATP-grasp domain; Region: ATP-grasp_4; cl17255 530564006226 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 530564006227 Pyruvate carboxylase and Transcarboxylase 5S, carboxyltransferase domain; Region: DRE_TIM_PC_TC_5S; cd07937 530564006228 active site 530564006229 catalytic residues [active] 530564006230 metal binding site [ion binding]; metal-binding site 530564006231 homodimer binding site [polypeptide binding]; other site 530564006232 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 530564006233 carboxyltransferase (CT) interaction site; other site 530564006234 biotinylation site [posttranslational modification]; other site 530564006235 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 530564006236 Biotin-(acetyl-CoA carboxylase) ligase [Coenzyme metabolism]; Region: BirA; COG0340 530564006237 MerR HTH family regulatory protein; Region: MerR_1; pfam13411 530564006238 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 530564006239 DNA binding residues [nucleotide binding] 530564006240 B12 binding domain; Region: B12-binding_2; pfam02607 530564006241 B12 binding domain (B12-BD). Most of the members bind different cobalamid derivates, like B12 (adenosylcobamide) or methylcobalamin or methyl-Co(III) 5-hydroxybenzimidazolylcobamide. This domain is found in several enzymes, such as glutamate mutase; Region: B12-binding_like; cl00293 530564006242 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564006243 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 530564006244 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564006245 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564006246 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 530564006247 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564006248 Sulfatase; Region: Sulfatase; cl17466 530564006249 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 530564006250 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564006251 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564006252 L-type amino acid transporter; Region: 2A0308; TIGR00911 530564006253 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 530564006254 Trp docking motif [polypeptide binding]; other site 530564006255 active site 530564006256 PQQ-like domain; Region: PQQ_2; pfam13360 530564006257 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 530564006258 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564006259 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564006260 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 530564006261 N-terminal catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_1; cd00649 530564006262 dimer interface [polypeptide binding]; other site 530564006263 active site 530564006264 heme binding site [chemical binding]; other site 530564006265 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 530564006266 Transcriptional regulator [Transcription]; Region: LysR; COG0583 530564006267 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 530564006268 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 530564006269 dimerization interface [polypeptide binding]; other site 530564006270 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 530564006271 Cro/C1-type HTH DNA-binding domain; Region: HTH_26; pfam13443 530564006272 non-specific DNA binding site [nucleotide binding]; other site 530564006273 salt bridge; other site 530564006274 sequence-specific DNA binding site [nucleotide binding]; other site 530564006275 CHC2 zinc finger; Region: zf-CHC2; cl17510 530564006276 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 530564006277 active site 530564006278 metal binding site [ion binding]; metal-binding site 530564006279 interdomain interaction site; other site 530564006280 AAA domain; Region: AAA_25; pfam13481 530564006281 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 530564006282 Walker A motif; other site 530564006283 ATP binding site [chemical binding]; other site 530564006284 Walker B motif; other site 530564006285 Helix-turn-helix domain; Region: HTH_17; pfam12728 530564006286 Domain of unknown function (DUF303); Region: DUF303; pfam03629 530564006287 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 530564006288 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 530564006289 Walker A/P-loop; other site 530564006290 ATP binding site [chemical binding]; other site 530564006291 Q-loop/lid; other site 530564006292 ABC transporter signature motif; other site 530564006293 Walker B; other site 530564006294 D-loop; other site 530564006295 H-loop/switch region; other site 530564006296 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 530564006297 HlyD family secretion protein; Region: HlyD_3; pfam13437 530564006298 Outer membrane efflux protein; Region: OEP; pfam02321 530564006299 Outer membrane efflux protein; Region: OEP; pfam02321 530564006300 Rrf2 family protein; Region: rrf2_super; TIGR00738 530564006301 Transcriptional regulator; Region: Rrf2; pfam02082 530564006302 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 530564006303 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 530564006304 active site 530564006305 trimer interface [polypeptide binding]; other site 530564006306 allosteric site; other site 530564006307 active site lid [active] 530564006308 hexamer (dimer of trimers) interface [polypeptide binding]; other site 530564006309 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 530564006310 Rhomboid family; Region: Rhomboid; pfam01694 530564006311 Competence-damaged protein; Region: CinA; pfam02464 530564006312 Cytidylyltransferase; Region: CTP_transf_2; pfam01467 530564006313 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 530564006314 active site 530564006315 HIGH motif; other site 530564006316 nucleotide binding site [chemical binding]; other site 530564006317 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 530564006318 EamA-like transporter family; Region: EamA; pfam00892 530564006319 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564006320 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 530564006321 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564006322 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 530564006323 phosphodiesterase; Provisional; Region: PRK12704 530564006324 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 530564006325 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 530564006326 phosphopeptide binding site; other site 530564006327 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 530564006328 Catalytic domain of Protein Kinases; Region: PKc; cd00180 530564006329 active site 530564006330 ATP binding site [chemical binding]; other site 530564006331 substrate binding site [chemical binding]; other site 530564006332 activation loop (A-loop); other site 530564006333 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 530564006334 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 530564006335 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 530564006336 DNA binding residues [nucleotide binding] 530564006337 Hemin uptake protein hemP; Region: hemP; pfam10636 530564006338 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 530564006339 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 530564006340 active site 530564006341 NAD binding site [chemical binding]; other site 530564006342 metal binding site [ion binding]; metal-binding site 530564006343 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 530564006344 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 530564006345 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564006346 Walker A motif; other site 530564006347 ATP binding site [chemical binding]; other site 530564006348 Walker B motif; other site 530564006349 arginine finger; other site 530564006350 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 530564006351 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 530564006352 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 530564006353 Na binding site [ion binding]; other site 530564006354 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 530564006355 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 530564006356 transmembrane helices; other site 530564006357 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 530564006358 FOG: TPR repeat [General function prediction only]; Region: NrfG; COG0457 530564006359 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564006360 TPR motif; other site 530564006361 binding surface 530564006362 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564006363 binding surface 530564006364 TPR motif; other site 530564006365 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564006366 binding surface 530564006367 TPR motif; other site 530564006368 Domain of unknown function (DUF4159); Region: DUF4159; pfam13709 530564006369 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 530564006370 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 530564006371 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 530564006372 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 530564006373 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 530564006374 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564006375 binding surface 530564006376 TPR motif; other site 530564006377 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 530564006378 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 530564006379 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 530564006380 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564006381 binding surface 530564006382 Tetratricopeptide repeat; Region: TPR_16; pfam13432 530564006383 TPR motif; other site 530564006384 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 530564006385 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 530564006386 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564006387 binding surface 530564006388 TPR motif; other site 530564006389 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564006390 binding surface 530564006391 TPR motif; other site 530564006392 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564006393 TPR motif; other site 530564006394 binding surface 530564006395 Tetratricopeptide repeat; Region: TPR_16; pfam13432 530564006396 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564006397 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cl00379 530564006398 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564006399 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564006400 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564006401 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 530564006402 c-di-GMP phosphodiesterase class II (HD-GYP domain) [Signal transduction mechanisms]; Region: COG2206 530564006403 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 530564006404 Zn2+ binding site [ion binding]; other site 530564006405 Mg2+ binding site [ion binding]; other site 530564006406 Caspase, interleukin-1 beta converting enzyme (ICE) homologues; Cysteine-dependent aspartate-directed proteases that mediate programmed cell death (apoptosis). Caspases are synthesized as inactive zymogens and activated by proteolysis of the peptide...; Region: CASc; cl00042 530564006407 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 530564006408 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_15; cd07264 530564006409 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 530564006410 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 530564006411 Walker A/P-loop; other site 530564006412 ATP binding site [chemical binding]; other site 530564006413 Q-loop/lid; other site 530564006414 ABC transporter signature motif; other site 530564006415 Walker B; other site 530564006416 D-loop; other site 530564006417 H-loop/switch region; other site 530564006418 phosphate ABC transporter, permease protein PstA; Region: 3a0107s02c; TIGR00974 530564006419 ABC-type phosphate transport system, permease component [Inorganic ion transport and metabolism]; Region: PstC; COG0573 530564006420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 530564006421 dimer interface [polypeptide binding]; other site 530564006422 conserved gate region; other site 530564006423 putative PBP binding loops; other site 530564006424 ABC-ATPase subunit interface; other site 530564006425 PBP superfamily domain; Region: PBP_like_2; cl17296 530564006426 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 530564006427 active site 530564006428 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 530564006429 DNA segregation ATPase FtsK/SpoIIIE and related proteins [Cell division and chromosome partitioning]; Region: FtsK; COG1674 530564006430 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 530564006431 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 530564006432 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK00130 530564006433 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 530564006434 RNA binding site [nucleotide binding]; other site 530564006435 active site 530564006436 2-methylcitrate dehydratase; Region: prpD; TIGR02330 530564006437 MmgE/PrpD family; Region: MmgE_PrpD; cl00912 530564006438 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 530564006439 dimer interface [polypeptide binding]; other site 530564006440 active site 530564006441 Schiff base residues; other site 530564006442 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 530564006443 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 530564006444 inhibitor-cofactor binding pocket; inhibition site 530564006445 pyridoxal 5'-phosphate binding site [chemical binding]; other site 530564006446 catalytic residue [active] 530564006447 GMP synthase; Reviewed; Region: guaA; PRK00074 530564006448 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 530564006449 AMP/PPi binding site [chemical binding]; other site 530564006450 candidate oxyanion hole; other site 530564006451 catalytic triad [active] 530564006452 potential glutamine specificity residues [chemical binding]; other site 530564006453 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 530564006454 ATP Binding subdomain [chemical binding]; other site 530564006455 Ligand Binding sites [chemical binding]; other site 530564006456 Dimerization subdomain; other site 530564006457 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 530564006458 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39G; cd02423 530564006459 putative active site [active] 530564006460 Putative MetA-pathway of phenol degradation; Region: Phenol_MetA_deg; cl01768 530564006461 Uncharacterized conserved protein [Function unknown]; Region: COG4850 530564006462 Uncharacterized conserved protein (DUF2183); Region: DUF2183; pfam09949 530564006463 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 530564006464 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 530564006465 active site 530564006466 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 530564006467 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 530564006468 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 530564006469 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 530564006470 substrate binding site [chemical binding]; other site 530564006471 ATP binding site [chemical binding]; other site 530564006472 Helix-turn-helix domain; Region: HTH_17; pfam12728 530564006473 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 530564006474 active site 530564006475 phosphorylation site [posttranslational modification] 530564006476 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 530564006477 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 530564006478 active site 530564006479 dimerization interface [polypeptide binding]; other site 530564006480 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 530564006481 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 530564006482 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 530564006483 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 530564006484 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 530564006485 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 530564006486 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 530564006487 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 530564006488 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 530564006489 active site 530564006490 metal binding site [ion binding]; metal-binding site 530564006491 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases [Signal transduction mechanisms]; Region: ApaH; COG0639 530564006492 glycogen branching enzyme; Provisional; Region: PRK05402 530564006493 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 530564006494 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 530564006495 active site 530564006496 catalytic site [active] 530564006497 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 530564006498 RNase H is an endonuclease that cleaves the RNA strand of an RNA/DNA hybrid in a sequence non-specific manner; Region: RNase_H; cl14782 530564006499 active site 530564006500 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 530564006501 intracellular protease, PfpI family; Region: PfpI; TIGR01382 530564006502 conserved cys residue [active] 530564006503 Peptidase C26; Region: Peptidase_C26; pfam07722 530564006504 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 530564006505 catalytic triad [active] 530564006506 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 530564006507 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 530564006508 dimer interface [polypeptide binding]; other site 530564006509 active site 530564006510 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 530564006511 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 530564006512 RNA binding surface [nucleotide binding]; other site 530564006513 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 530564006514 active site 530564006515 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 530564006516 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 530564006517 Bacterial transglutaminase-like N-terminal region; Region: Bact_transglu_N; pfam08379 530564006518 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 530564006519 A circularly permuted ATPgrasp; Region: CP_ATPgrasp_1; cl17448 530564006520 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 530564006521 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 530564006522 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2307 530564006523 A predicted alpha-helical domain with a conserved ER motif; Region: Alpha-E; pfam04168 530564006524 Uncharacterized conserved protein [Function unknown]; Region: COG2308 530564006525 Coagulation factor 5/8 C-terminal domain, discoidin domain; Cell surface-attached carbohydrate-binding domain, present in eukaryotes and assumed to have horizontally transferred to eubacterial genomes; Region: FA58C; cl12042 530564006526 Prokaryotic dksA/traR C4-type zinc finger; Region: zf-dskA_traR; cl00755 530564006527 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 530564006528 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 530564006529 Catalytic domain of Protein Kinases; Region: PKc; cd00180 530564006530 active site 530564006531 ATP binding site [chemical binding]; other site 530564006532 substrate binding site [chemical binding]; other site 530564006533 activation loop (A-loop); other site 530564006534 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 530564006535 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 530564006536 peptide binding site [polypeptide binding]; other site 530564006537 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 530564006538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 530564006539 dimer interface [polypeptide binding]; other site 530564006540 conserved gate region; other site 530564006541 putative PBP binding loops; other site 530564006542 ABC-ATPase subunit interface; other site 530564006543 nickel ABC transporter, permease subunit NikC; Region: nickel_nikC; TIGR02790 530564006544 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 530564006545 dimer interface [polypeptide binding]; other site 530564006546 conserved gate region; other site 530564006547 putative PBP binding loops; other site 530564006548 ABC-ATPase subunit interface; other site 530564006549 Flavin reductase like domain; Region: Flavin_Reduct; pfam01613 530564006550 Peroxiredoxin (PRX)-like 1 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a conserved cysteine that aligns to the first cysteine in the CXXC motif of TRX. This does not correspond to the peroxidatic...; Region: PRX_like1; cd02969 530564006551 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 530564006552 putative catalytic residue [active] 530564006553 Copper type II ascorbate-dependent monooxygenase, C-terminal domain; Region: Cu2_monoox_C; pfam03712 530564006554 enolase; Provisional; Region: eno; PRK00077 530564006555 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 530564006556 dimer interface [polypeptide binding]; other site 530564006557 metal binding site [ion binding]; metal-binding site 530564006558 substrate binding pocket [chemical binding]; other site 530564006559 Protein of unknown function (DUF1571); Region: DUF1571; pfam07608 530564006560 HEAT repeats; Region: HEAT_2; pfam13646 530564006561 N-carbamoylputrescine amidase; Region: agmatine_aguB; TIGR03381 530564006562 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 530564006563 active site 530564006564 catalytic triad [active] 530564006565 dimer interface [polypeptide binding]; other site 530564006566 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 530564006567 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cl00279 530564006568 active site 530564006569 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 530564006570 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 530564006571 active site 530564006572 Carbon starvation protein, predicted membrane protein [Signal transduction mechanisms]; Region: CstA; COG1966 530564006573 Carbon starvation protein CstA; Region: CstA; pfam02554 530564006574 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 530564006575 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 530564006576 dimer interface [polypeptide binding]; other site 530564006577 phosphorylation site [posttranslational modification] 530564006578 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 530564006579 ATP binding site [chemical binding]; other site 530564006580 G-X-G motif; other site 530564006581 Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3458 530564006582 Uncharacterized conserved protein [Function unknown]; Region: COG1359 530564006583 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 530564006584 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 530564006585 NAD(P) binding site [chemical binding]; other site 530564006586 active site 530564006587 Tetratricopeptide repeat; Region: TPR_16; pfam13432 530564006588 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564006589 TPR motif; other site 530564006590 binding surface 530564006591 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564006592 binding surface 530564006593 TPR motif; other site 530564006594 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564006595 binding surface 530564006596 TPR motif; other site 530564006597 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 530564006598 tol-pal system protein YbgF; Region: tol_pal_ybgF; TIGR02795 530564006599 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564006600 binding surface 530564006601 TPR motif; other site 530564006602 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 530564006603 binding surface 530564006604 TPR motif; other site 530564006605 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 530564006606 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 530564006607 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 530564006608 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 530564006609 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 530564006610 Prenyltransferase-like; Region: Prenyltrans_1; pfam13243 530564006611 HD superfamily phosphohydrolases [General function prediction only]; Region: COG1078 530564006612 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 530564006613 Zn2+ binding site [ion binding]; other site 530564006614 Mg2+ binding site [ion binding]; other site 530564006615 ACT domain-containing protein [General function prediction only]; Region: COG4747 530564006616 N-terminal ACT domain of a novel protein composed almost entirely of two tandem ACT domains; Region: ACT_Bt0572_1; cd04908 530564006617 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 530564006618 Horizontally Transferred TransMembrane Domain; Region: HTTM; smart00752 530564006619 Planctomycetes uncharacterized domain TIGR03000; Region: plancto_dom_1 530564006620 Planctomycetes uncharacterized domain TIGR03000; Region: plancto_dom_1 530564006621 Protein-L-isoaspartate carboxylmethyltransferase [Posttranslational modification, protein turnover, chaperones]; Region: Pcm; COG2518 530564006622 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 530564006623 S-adenosylmethionine binding site [chemical binding]; other site 530564006624 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 530564006625 hypothetical protein; Provisional; Region: PRK02399 530564006626 Uncharacterized protein family (UPF0261); Region: UPF0261; pfam06792 530564006627 TIM-barrel signal transduction protein; Region: TIM-br_sig_trns; pfam09370 530564006628 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 530564006629 Sulfatase; Region: Sulfatase; pfam00884 530564006630 Sulfatase; Region: Sulfatase; cl17466 530564006631 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 530564006632 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 530564006633 Walker A/P-loop; other site 530564006634 ATP binding site [chemical binding]; other site 530564006635 Q-loop/lid; other site 530564006636 ABC transporter signature motif; other site 530564006637 Walker B; other site 530564006638 D-loop; other site 530564006639 H-loop/switch region; other site 530564006640 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Sulfolobus solfataricus (Ss) and its homologs from archaea and bacteria; Region: NTP-PPase_SsMazG; cd11535 530564006641 metal binding site [ion binding]; metal-binding site 530564006642 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 530564006643 iron-sulfur cluster [ion binding]; other site 530564006644 [2Fe-2S] cluster binding site [ion binding]; other site 530564006645 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 530564006646 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 530564006647 glucose-6-phosphate isomerase; Provisional; Region: PRK00973 530564006648 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 530564006649 active site 530564006650 dimer interface [polypeptide binding]; other site 530564006651 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 530564006652 dimer interface [polypeptide binding]; other site 530564006653 active site 530564006654 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04135 530564006655 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 530564006656 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 530564006657 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 530564006658 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 530564006659 Prenyltransferase-like; Region: Prenyltrans_1; pfam13243 530564006660 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 530564006661 metal ion-dependent adhesion site (MIDAS); other site 530564006662 CARDB; Region: CARDB; pfam07705 530564006663 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 530564006664 Aerotolerance regulator N-terminal; Region: BatA; pfam07584 530564006665 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 530564006666 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 530564006667 metal ion-dependent adhesion site (MIDAS); other site 530564006668 MoxR-like ATPases [General function prediction only]; Region: COG0714 530564006669 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564006670 Walker A motif; other site 530564006671 ATP binding site [chemical binding]; other site 530564006672 Walker B motif; other site 530564006673 arginine finger; other site 530564006674 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 530564006675 Trp docking motif [polypeptide binding]; other site 530564006676 active site 530564006677 Protein of unknown function (DUF983); Region: DUF983; cl02211 530564006678 Protein of unknown function (DUF420); Region: DUF420; pfam04238 530564006679 SCO (an acronym for Synthesis of Cytochrome c Oxidase) family; composed of proteins similar to Sco1, a membrane-anchored protein possessing a soluble domain with a TRX fold. Members of this family are required for the proper assembly of cytochrome c...; Region: SCO; cd02968 530564006680 Cu(I) binding site [ion binding]; other site 530564006681 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 530564006682 ABC-2 type transporter; Region: ABC2_membrane; cl17235 530564006683 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 530564006684 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 530564006685 Walker A/P-loop; other site 530564006686 ATP binding site [chemical binding]; other site 530564006687 Q-loop/lid; other site 530564006688 ABC transporter signature motif; other site 530564006689 Walker B; other site 530564006690 D-loop; other site 530564006691 H-loop/switch region; other site 530564006692 Prokaryotic Cytochrome C oxidase subunit IV; Region: COX4_pro; pfam03626 530564006693 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 530564006694 Subunit I/III interface [polypeptide binding]; other site 530564006695 Heme-copper oxidase subunit III. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which couple the reduction of molecular oxygen to water to, proton pumping across the membrane. The...; Region: Heme_Cu_Oxidase_III_like; cd00386 530564006696 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 530564006697 UbiA prenyltransferase family; Region: UbiA; pfam01040 530564006698 Cytochrome oxidase assembly protein; Region: COX15-CtaA; pfam02628 530564006699 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 530564006700 cytochrome c oxidase, subunit I; Region: CtaD_CoxA; TIGR02891 530564006701 Heme/copper-type cytochrome/quinol oxidases, subunit 2 [Energy production and conversion]; Region: CyoA; COG1622 530564006702 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 530564006703 Cytochrome c; Region: Cytochrom_C; pfam00034 530564006704 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 530564006705 Uncharacterized conserved protein [Function unknown]; Region: COG4198 530564006706 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 530564006707 Cytochrome b(C-terminus)/b6/petD: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: cytochrome_b_C; cl00193 530564006708 intrachain domain interface; other site 530564006709 Qi binding site; other site 530564006710 Qo binding site; other site 530564006711 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 530564006712 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 530564006713 heme bH binding site [chemical binding]; other site 530564006714 intrachain domain interface; other site 530564006715 Qi binding site; other site 530564006716 heme bL binding site [chemical binding]; other site 530564006717 interchain domain interface [polypeptide binding]; other site 530564006718 Qo binding site; other site 530564006719 Rieske Fe-S protein [Energy production and conversion]; Region: QcrA; COG0723 530564006720 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 530564006721 iron-sulfur cluster [ion binding]; other site 530564006722 [2Fe-2S] cluster binding site [ion binding]; other site 530564006723 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 530564006724 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 530564006725 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 530564006726 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 530564006727 YacP-like NYN domain; Region: NYN_YacP; cl01491 530564006728 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 530564006729 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 530564006730 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 530564006731 putative active site [active] 530564006732 heme pocket [chemical binding]; other site 530564006733 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 530564006734 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 530564006735 putative active site [active] 530564006736 heme pocket [chemical binding]; other site 530564006737 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 530564006738 heme pocket [chemical binding]; other site 530564006739 putative active site [active] 530564006740 PAS fold; Region: PAS_3; pfam08447 530564006741 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 530564006742 heme pocket [chemical binding]; other site 530564006743 putative active site [active] 530564006744 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 530564006745 PAS fold; Region: PAS_3; pfam08447 530564006746 putative active site [active] 530564006747 heme pocket [chemical binding]; other site 530564006748 PAS domain S-box; Region: sensory_box; TIGR00229 530564006749 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 530564006750 putative active site [active] 530564006751 heme pocket [chemical binding]; other site 530564006752 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 530564006753 PAS domain; Region: PAS; smart00091 530564006754 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 530564006755 dimer interface [polypeptide binding]; other site 530564006756 phosphorylation site [posttranslational modification] 530564006757 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 530564006758 ATP binding site [chemical binding]; other site 530564006759 Mg2+ binding site [ion binding]; other site 530564006760 G-X-G motif; other site 530564006761 Response regulator receiver domain; Region: Response_reg; pfam00072 530564006762 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564006763 active site 530564006764 phosphorylation site [posttranslational modification] 530564006765 intermolecular recognition site; other site 530564006766 dimerization interface [polypeptide binding]; other site 530564006767 HEAT repeats; Region: HEAT_2; pfam13646 530564006768 HEAT repeats; Region: HEAT_2; pfam13646 530564006769 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cl00474 530564006770 active site 530564006771 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cl00197 530564006772 active site 530564006773 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK13905 530564006774 FAD binding domain; Region: FAD_binding_4; pfam01565 530564006775 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 530564006776 Global regulator protein family; Region: CsrA; pfam02599 530564006777 Alanine-glyoxylate aminotransferase (AGAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to alanine-glyoxylate aminotransferase (AGAT); Region: AGAT_like; cd06451 530564006778 homodimer interface [polypeptide binding]; other site 530564006779 pyridoxal 5'-phosphate binding site [chemical binding]; other site 530564006780 catalytic residue [active] 530564006781 Sulfotransferase domain; Region: Sulfotransfer_1; pfam00685 530564006782 Sulfotransferase family; Region: Sulfotransfer_3; pfam13469 530564006783 haloacid dehalogenase-like hydrolase family protein; Region: PLN02919 530564006784 Glycosyl Hydrolase Family 88; Region: Glyco_hydro_88; pfam07470 530564006785 potential frameshift: common BLAST hit: gi|32473213|ref|NP_866207.1| signal peptide 530564006786 HEAT repeats; Region: HEAT_2; pfam13646 530564006787 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 530564006788 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 530564006789 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 530564006790 NPCBM/NEW2 domain; Region: NPCBM; cl07060 530564006791 NPCBM/NEW2 domain; Region: NPCBM; cl07060 530564006792 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 530564006793 HEAT repeats; Region: HEAT_2; pfam13646 530564006794 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 530564006795 MraW methylase family; Region: Methyltransf_5; cl17771 530564006796 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 530564006797 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 530564006798 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 530564006799 Queuosine biosynthesis protein; Region: Queuosine_synth; pfam02547 530564006800 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 530564006801 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 530564006802 HlyD family secretion protein; Region: HlyD_3; pfam13437 530564006803 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 530564006804 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 530564006805 Walker A/P-loop; other site 530564006806 ATP binding site [chemical binding]; other site 530564006807 Q-loop/lid; other site 530564006808 ABC transporter signature motif; other site 530564006809 Walker B; other site 530564006810 D-loop; other site 530564006811 H-loop/switch region; other site 530564006812 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 530564006813 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 530564006814 FtsX-like permease family; Region: FtsX; pfam02687 530564006815 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 530564006816 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 530564006817 FtsX-like permease family; Region: FtsX; pfam02687 530564006818 DEAD-like helicases superfamily; Region: DEXDc; smart00487 530564006819 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 530564006820 ATP binding site [chemical binding]; other site 530564006821 putative Mg++ binding site [ion binding]; other site 530564006822 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 530564006823 nucleotide binding region [chemical binding]; other site 530564006824 ATP-binding site [chemical binding]; other site 530564006825 RQC domain; Region: RQC; pfam09382 530564006826 FtsH Extracellular; Region: FtsH_ext; pfam06480 530564006827 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 530564006828 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564006829 Walker A motif; other site 530564006830 ATP binding site [chemical binding]; other site 530564006831 Walker B motif; other site 530564006832 arginine finger; other site 530564006833 Peptidase family M41; Region: Peptidase_M41; pfam01434 530564006834 GTPase RsgA; Reviewed; Region: PRK00098 530564006835 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 530564006836 RNA binding site [nucleotide binding]; other site 530564006837 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 530564006838 GTPase/Zn-binding domain interface [polypeptide binding]; other site 530564006839 GTP/Mg2+ binding site [chemical binding]; other site 530564006840 G4 box; other site 530564006841 G5 box; other site 530564006842 G1 box; other site 530564006843 Switch I region; other site 530564006844 G2 box; other site 530564006845 G3 box; other site 530564006846 Switch II region; other site 530564006847 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 530564006848 Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes [Amino acid transport and metabolism]; Region: NifS; COG1104 530564006849 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 530564006850 catalytic residue [active] 530564006851 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 530564006852 Zinc-dependent metalloprotease. This super-family of metalloproteases contains two major branches, the astacin-like proteases and the adamalysin/reprolysin-like proteases. Both branches have wide phylogenetic distribution, and contain sub-families, which...; Region: ZnMc; cl00064 530564006853 active site 530564006854 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 530564006855 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 530564006856 putative ligand binding site [chemical binding]; other site 530564006857 putative NAD binding site [chemical binding]; other site 530564006858 catalytic site [active] 530564006859 Precorrin-6Y methyltransferase, the cobalamin biosynthesis enzyme CbiE; Region: Precorrin-6Y-methylase; cd11644 530564006860 putative homodimer interface [polypeptide binding]; other site 530564006861 active site 530564006862 SAM binding site [chemical binding]; other site 530564006863 Precorrin-6B methylase 2 [Coenzyme metabolism]; Region: CobL; COG2242 530564006864 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 530564006865 S-adenosylmethionine binding site [chemical binding]; other site 530564006866 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 530564006867 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 530564006868 Domain of unknown function (DUF4343); Region: DUF4343; pfam14243 530564006869 ABC-type phosphate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PstB; COG1117 530564006870 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 530564006871 Walker A/P-loop; other site 530564006872 ATP binding site [chemical binding]; other site 530564006873 Q-loop/lid; other site 530564006874 ABC transporter signature motif; other site 530564006875 Walker B; other site 530564006876 D-loop; other site 530564006877 H-loop/switch region; other site 530564006878 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 530564006879 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 530564006880 hypothetical protein; Provisional; Region: PRK09256 530564006881 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 530564006882 Trp docking motif [polypeptide binding]; other site 530564006883 active site 530564006884 PQQ-like domain; Region: PQQ_2; pfam13360 530564006885 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 530564006886 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 530564006887 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 530564006888 Nitrogen regulatory protein P-II; Region: P-II; smart00938 530564006889 BON domain; Region: BON; pfam04972 530564006890 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564006891 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 530564006892 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564006893 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564006894 selenocysteine synthase; Provisional; Region: PRK04311 530564006895 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 530564006896 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 530564006897 Staphylococcal nuclease homologues; Region: SNc; smart00318 530564006898 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cl00140 530564006899 Catalytic site; other site 530564006900 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 530564006901 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 530564006902 active site 530564006903 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 530564006904 RibD C-terminal domain; Region: RibD_C; cl17279 530564006905 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 530564006906 4Fe-4S binding domain; Region: Fer4; cl02805 530564006907 Domain of unknown function (DUF3470); Region: DUF3470; pfam11953 530564006908 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 530564006909 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 530564006910 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 530564006911 DNA binding residues [nucleotide binding] 530564006912 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 530564006913 Peptidase family U32; Region: Peptidase_U32; pfam01136 530564006914 Collagenase; Region: DUF3656; pfam12392 530564006915 Peptidase family U32; Region: Peptidase_U32; cl03113 530564006916 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 530564006917 N- and C-terminal domain interface [polypeptide binding]; other site 530564006918 rhamnulokinase; Region: rhamnulo_kin; TIGR02627 530564006919 active site 530564006920 putative catalytic site [active] 530564006921 metal binding site [ion binding]; metal-binding site 530564006922 ATP binding site [chemical binding]; other site 530564006923 carbohydrate binding site [chemical binding]; other site 530564006924 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 530564006925 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 530564006926 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 530564006927 Helix-turn-helix domain; Region: HTH_17; pfam12728 530564006928 Response regulator receiver domain; Region: Response_reg; pfam00072 530564006929 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564006930 active site 530564006931 phosphorylation site [posttranslational modification] 530564006932 intermolecular recognition site; other site 530564006933 dimerization interface [polypeptide binding]; other site 530564006934 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564006935 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 530564006936 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 530564006937 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 530564006938 ApbE family; Region: ApbE; pfam02424 530564006939 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 530564006940 Myo-inositol-1-phosphate synthase; Region: NAD_binding_5; pfam07994 530564006941 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 530564006942 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 530564006943 pyridoxal 5'-phosphate binding site [chemical binding]; other site 530564006944 homodimer interface [polypeptide binding]; other site 530564006945 catalytic residue [active] 530564006946 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 530564006947 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 530564006948 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 530564006949 ring oligomerisation interface [polypeptide binding]; other site 530564006950 ATP/Mg binding site [chemical binding]; other site 530564006951 stacking interactions; other site 530564006952 hinge regions; other site 530564006953 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 530564006954 oligomerisation interface [polypeptide binding]; other site 530564006955 mobile loop; other site 530564006956 roof hairpin; other site 530564006957 chaperonin GroL; Region: GroEL; TIGR02348 530564006958 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 530564006959 ring oligomerisation interface [polypeptide binding]; other site 530564006960 ATP/Mg binding site [chemical binding]; other site 530564006961 stacking interactions; other site 530564006962 hinge regions; other site 530564006963 chaperone protein DnaJ; Provisional; Region: PRK10767 530564006964 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 530564006965 HSP70 interaction site [polypeptide binding]; other site 530564006966 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 530564006967 substrate binding site [polypeptide binding]; other site 530564006968 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 530564006969 Zn binding sites [ion binding]; other site 530564006970 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 530564006971 dimer interface [polypeptide binding]; other site 530564006972 GrpE; Region: GrpE; pfam01025 530564006973 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 530564006974 dimer interface [polypeptide binding]; other site 530564006975 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 530564006976 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 530564006977 Domain of unknown function (DUF329); Region: DUF329; pfam03884 530564006978 Catalytic domain of Protein Kinases; Region: PKc; cd00180 530564006979 active site 530564006980 ATP binding site [chemical binding]; other site 530564006981 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 530564006982 substrate binding site [chemical binding]; other site 530564006983 activation loop (A-loop); other site 530564006984 Uncharacterized protein with a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG4867 530564006985 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 530564006986 metal ion-dependent adhesion site (MIDAS); other site 530564006987 threonine dehydratase; Provisional; Region: PRK07334 530564006988 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cl00342 530564006989 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 530564006990 catalytic residue [active] 530564006991 C-terminal ACT domain of biodegradative (catabolic) threonine dehydratase II (ThrD-II) and other related ACT domains; Region: ACT_ThrD-II-like; cd04886 530564006992 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 530564006993 S-formylglutathione hydrolase; Region: PLN02442 530564006994 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 530564006995 dihydrodipicolinate synthase; Region: dapA; TIGR00674 530564006996 dimer interface [polypeptide binding]; other site 530564006997 active site 530564006998 catalytic residue [active] 530564006999 Mg/Co/Ni transporter MgtE (contains CBS domain) [Inorganic ion transport and metabolism]; Region: MgtE; COG2239 530564007000 MgtE intracellular N domain; Region: MgtE_N; pfam03448 530564007001 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domain in the magnesium transporter, MgtE. MgtE and its homologs are found in eubacteria, archaebacteria, and eukaryota. Members of this family transport Mg2+ or other...; Region: CBS_pair_Mg_transporter; cd04606 530564007002 Divalent cation transporter; Region: MgtE; pfam01769 530564007003 Cobyrinic acid a,c-diamide synthase [Coenzyme metabolism]; Region: CobB; COG1797 530564007004 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 530564007005 conserved cys residue [active] 530564007006 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 530564007007 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 530564007008 Prenyltransferase-like; Region: Prenyltrans_1; pfam13243 530564007009 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 530564007010 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 530564007011 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 530564007012 Transcriptional regulators [Transcription]; Region: PurR; COG1609 530564007013 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 530564007014 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 530564007015 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 530564007016 Haem-binding domain; Region: Haem_bd; pfam14376 530564007017 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 530564007018 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 530564007019 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 530564007020 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 530564007021 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 530564007022 Nitrilases, cyanide hydratase (CH)s, and similar proteins (class 1 nitrilases); Region: nitrilases_CHs; cd07564 530564007023 Predicted amidohydrolase [General function prediction only]; Region: COG0388 530564007024 putative active site [active] 530564007025 catalytic triad [active] 530564007026 putative dimer interface [polypeptide binding]; other site 530564007027 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 530564007028 Trp docking motif [polypeptide binding]; other site 530564007029 active site 530564007030 PQQ-like domain; Region: PQQ_2; pfam13360 530564007031 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 530564007032 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 530564007033 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 530564007034 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 530564007035 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 530564007036 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 530564007037 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 530564007038 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564007039 active site 530564007040 phosphorylation site [posttranslational modification] 530564007041 intermolecular recognition site; other site 530564007042 dimerization interface [polypeptide binding]; other site 530564007043 CheB methylesterase; Region: CheB_methylest; pfam01339 530564007044 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 530564007045 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564007046 active site 530564007047 phosphorylation site [posttranslational modification] 530564007048 intermolecular recognition site; other site 530564007049 dimerization interface [polypeptide binding]; other site 530564007050 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 530564007051 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 530564007052 putative active site [active] 530564007053 heme pocket [chemical binding]; other site 530564007054 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 530564007055 putative active site [active] 530564007056 heme pocket [chemical binding]; other site 530564007057 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 530564007058 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 530564007059 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 530564007060 dimer interface [polypeptide binding]; other site 530564007061 putative CheW interface [polypeptide binding]; other site 530564007062 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 530564007063 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 530564007064 putative binding surface; other site 530564007065 active site 530564007066 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 530564007067 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 530564007068 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 530564007069 ATP binding site [chemical binding]; other site 530564007070 Mg2+ binding site [ion binding]; other site 530564007071 G-X-G motif; other site 530564007072 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 530564007073 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 530564007074 PAS domain S-box; Region: sensory_box; TIGR00229 530564007075 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 530564007076 putative active site [active] 530564007077 heme pocket [chemical binding]; other site 530564007078 PAS domain S-box; Region: sensory_box; TIGR00229 530564007079 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 530564007080 putative active site [active] 530564007081 heme pocket [chemical binding]; other site 530564007082 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 530564007083 PAS fold; Region: PAS_3; pfam08447 530564007084 putative active site [active] 530564007085 heme pocket [chemical binding]; other site 530564007086 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 530564007087 dimer interface [polypeptide binding]; other site 530564007088 phosphorylation site [posttranslational modification] 530564007089 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 530564007090 ATP binding site [chemical binding]; other site 530564007091 Mg2+ binding site [ion binding]; other site 530564007092 G-X-G motif; other site 530564007093 response regulator FixJ; Provisional; Region: fixJ; PRK09390 530564007094 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564007095 active site 530564007096 phosphorylation site [posttranslational modification] 530564007097 intermolecular recognition site; other site 530564007098 dimerization interface [polypeptide binding]; other site 530564007099 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 530564007100 DNA binding residues [nucleotide binding] 530564007101 dimerization interface [polypeptide binding]; other site 530564007102 proton-translocating NADH-quinone oxidoreductase, chain M; Region: NDH_I_M; TIGR01972 530564007103 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 530564007104 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 530564007105 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 530564007106 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 530564007107 Uncharacterized protein conserved in bacteria (DUF2309); Region: DUF2309; pfam10070 530564007108 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 530564007109 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 530564007110 THF binding site; other site 530564007111 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 530564007112 substrate binding site [chemical binding]; other site 530564007113 THF binding site; other site 530564007114 zinc-binding site [ion binding]; other site 530564007115 PQQ-like domain; Region: PQQ_2; pfam13360 530564007116 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 530564007117 Trp docking motif [polypeptide binding]; other site 530564007118 active site 530564007119 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 530564007120 active site 530564007121 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564007122 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564007123 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 530564007124 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564007125 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564007126 PAS fold; Region: PAS_4; pfam08448 530564007127 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 530564007128 putative active site [active] 530564007129 heme pocket [chemical binding]; other site 530564007130 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 530564007131 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 530564007132 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 530564007133 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 530564007134 ABC exporter ATP-binding subunit, DevA family; Region: heterocyst_DevA; TIGR02982 530564007135 Walker A/P-loop; other site 530564007136 ATP binding site [chemical binding]; other site 530564007137 Q-loop/lid; other site 530564007138 ABC transporter signature motif; other site 530564007139 Walker B; other site 530564007140 D-loop; other site 530564007141 H-loop/switch region; other site 530564007142 DevC protein; Region: devC; TIGR01185 530564007143 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 530564007144 FtsX-like permease family; Region: FtsX; pfam02687 530564007145 ABC exporter membrane fusion protein, DevB family; Region: heterocyst_DevB; TIGR02971 530564007146 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 530564007147 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 530564007148 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 530564007149 Acetyl esterase (deacetylase) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3458 530564007150 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 530564007151 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 530564007152 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cd00229 530564007153 active site 530564007154 oxyanion hole [active] 530564007155 TPR repeat; Region: TPR_11; pfam13414 530564007156 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564007157 binding surface 530564007158 TPR motif; other site 530564007159 GDSL-like Lipase/Acylhydrolase family; Region: Lipase_GDSL_2; pfam13472 530564007160 catalytic triad [active] 530564007161 Predicted carbamoyl transferase, NodU family [Posttranslational modification, protein turnover, chaperones]; Region: COG2192 530564007162 Carbamoyltransferase; Region: CmcH_NodU; pfam02543 530564007163 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564007164 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 530564007165 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564007166 Carbohydrate Binding Module 6 (CBM6); appended to several carbohydrate binding enzymes, including several glycoside hydrolase (GH) family 26 mannanase domains; Region: CBM6_mannanase-like; cd04086 530564007167 putative metal binding site [ion binding]; other site 530564007168 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564007169 Domain of unknown function (DUF202); Region: DUF202; cl09954 530564007170 Predicted metalloprotease [General function prediction only]; Region: COG2321 530564007171 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 530564007172 Protocatechuate 3,4-dioxygenase (3,4-PCD) catalyzes the oxidative ring cleavage of 3,4-dihydroxybenzoate to produce beta-carboxy-cis,cis-muconate. 3,4-PCDs are large aggregates of 12 protomers, each composed of an alpha- and beta-subunit and an Fe3+ ion...; Region: 3,4-PCD; cd03459 530564007173 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_22; cd08359 530564007174 putative dimer interface [polypeptide binding]; other site 530564007175 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 530564007176 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 530564007177 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564007178 binding surface 530564007179 TPR motif; other site 530564007180 TPR repeat; Region: TPR_11; pfam13414 530564007181 TPR repeat; Region: TPR_11; pfam13414 530564007182 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564007183 binding surface 530564007184 TPR motif; other site 530564007185 Membrane-associated lipoprotein involved in thiamine biosynthesis [Coenzyme metabolism]; Region: ApbE; COG1477 530564007186 ApbE family; Region: ApbE; pfam02424 530564007187 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 530564007188 active site 530564007189 8-oxo-dGMP binding site [chemical binding]; other site 530564007190 nudix motif; other site 530564007191 metal binding site [ion binding]; metal-binding site 530564007192 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 530564007193 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 530564007194 IHF dimer interface [polypeptide binding]; other site 530564007195 IHF - DNA interface [nucleotide binding]; other site 530564007196 dihydroorotate dehydrogenase (subfamily 1) family protein; Region: pyrD_sub1_fam; TIGR01037 530564007197 Dihydroorotate dehydrogenase (DHOD) class 1B FMN-binding domain. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine...; Region: DHOD_1B_like; cd04740 530564007198 heterodimer interface [polypeptide binding]; other site 530564007199 active site 530564007200 FMN binding site [chemical binding]; other site 530564007201 homodimer interface [polypeptide binding]; other site 530564007202 substrate binding site [chemical binding]; other site 530564007203 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 530564007204 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 530564007205 active site 530564007206 HIGH motif; other site 530564007207 dimer interface [polypeptide binding]; other site 530564007208 KMSKS motif; other site 530564007209 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 530564007210 putative catalytic residues [active] 530564007211 HrpA-like helicases [DNA replication, recombination, and repair]; Region: HrpA; COG1643 530564007212 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 530564007213 ATP binding site [chemical binding]; other site 530564007214 putative Mg++ binding site [ion binding]; other site 530564007215 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 530564007216 nucleotide binding region [chemical binding]; other site 530564007217 ATP-binding site [chemical binding]; other site 530564007218 Helicase associated domain (HA2); Region: HA2; pfam04408 530564007219 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 530564007220 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 530564007221 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 530564007222 phosphopantothenoylcysteine decarboxylase; Validated; Region: PRK07313 530564007223 Flavoprotein; Region: Flavoprotein; pfam02441 530564007224 RNA polymerase Rpb6; Region: RNA_pol_Rpb6; pfam01192 530564007225 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 530564007226 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 530564007227 catalytic site [active] 530564007228 G-X2-G-X-G-K; other site 530564007229 hypothetical protein; Provisional; Region: PRK11820 530564007230 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 530564007231 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 530564007232 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 530564007233 triosephosphate isomerase; Provisional; Region: PRK14565 530564007234 substrate binding site [chemical binding]; other site 530564007235 dimer interface [polypeptide binding]; other site 530564007236 catalytic triad [active] 530564007237 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 530564007238 phospho-2-dehydro-3-deoxyheptonate aldolase; Region: DAHP_synth_Bsub; TIGR01361 530564007239 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 530564007240 pyrroline-5-carboxylate reductase; Region: PLN02688 530564007241 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 530564007242 trimer interface [polypeptide binding]; other site 530564007243 dimer interface [polypeptide binding]; other site 530564007244 putative active site [active] 530564007245 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 530564007246 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 530564007247 substrate binding pocket [chemical binding]; other site 530564007248 chain length determination region; other site 530564007249 substrate-Mg2+ binding site; other site 530564007250 catalytic residues [active] 530564007251 aspartate-rich region 1; other site 530564007252 active site lid residues [active] 530564007253 aspartate-rich region 2; other site 530564007254 Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304 530564007255 TPR repeat; Region: TPR_11; pfam13414 530564007256 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564007257 binding surface 530564007258 TPR motif; other site 530564007259 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564007260 binding surface 530564007261 TPR repeat; Region: TPR_11; pfam13414 530564007262 TPR motif; other site 530564007263 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 530564007264 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 530564007265 catalytic residue [active] 530564007266 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 530564007267 hydroxyglutarate oxidase; Provisional; Region: PRK11728 530564007268 Glycine cleavage system T protein (aminomethyltransferase) [Amino acid transport and metabolism]; Region: GcvT; COG0404 530564007269 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 530564007270 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 530564007271 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 530564007272 non-specific DNA binding site [nucleotide binding]; other site 530564007273 salt bridge; other site 530564007274 sequence-specific DNA binding site [nucleotide binding]; other site 530564007275 Cupin domain; Region: Cupin_2; pfam07883 530564007276 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 530564007277 intersubunit interface [polypeptide binding]; other site 530564007278 active site 530564007279 Zn2+ binding site [ion binding]; other site 530564007280 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1791 530564007281 Cupin domain; Region: Cupin_2; cl17218 530564007282 Predicted enolase-phosphatase [Energy production and conversion]; Region: COG4229 530564007283 Uncharacterized protein conserved in bacteria (DUF2059); Region: DUF2059; cl01243 530564007284 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 530564007285 motif II; other site 530564007286 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 530564007287 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 530564007288 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 530564007289 NADH dehydrogenase subunit J; Provisional; Region: PRK06433 530564007290 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 530564007291 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 530564007292 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 530564007293 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 530564007294 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 530564007295 NADH-ubiquinone oxidoreductase chain 4, amino terminus; Region: Oxidored_q5_N; pfam01059 530564007296 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 530564007297 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 530564007298 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 530564007299 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 530564007300 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 530564007301 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 530564007302 active site 530564007303 thioredoxin-disulfide reductase; Region: TRX_reduct; TIGR01292 530564007304 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 530564007305 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 530564007306 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 530564007307 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 530564007308 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 530564007309 benzoate transport; Region: 2A0115; TIGR00895 530564007310 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 530564007311 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 530564007312 putative dimer interface [polypeptide binding]; other site 530564007313 putative anticodon binding site; other site 530564007314 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 530564007315 homodimer interface [polypeptide binding]; other site 530564007316 motif 1; other site 530564007317 motif 2; other site 530564007318 active site 530564007319 motif 3; other site 530564007320 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 530564007321 active site residue [active] 530564007322 Citrate synthase (CS), citryl-CoA lyase (CCL), the C-terminal portion of the single-subunit type ATP-citrate lyase (ACL) and the C-terminal portion of the large subunit of the two-subunit type ACL. CS catalyzes the condensation of acetyl coenzyme A; Region: CS_ACL-C_CCL; cl00416 530564007323 Citrate synthase; Region: Citrate_synt; pfam00285 530564007324 oxalacetate binding site [chemical binding]; other site 530564007325 citrylCoA binding site [chemical binding]; other site 530564007326 coenzyme A binding site [chemical binding]; other site 530564007327 catalytic triad [active] 530564007328 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 530564007329 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 530564007330 tetramer interface [polypeptide binding]; other site 530564007331 active site 530564007332 Mg2+/Mn2+ binding site [ion binding]; other site 530564007333 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 530564007334 putative active site [active] 530564007335 putative CoA binding site [chemical binding]; other site 530564007336 nudix motif; other site 530564007337 metal binding site [ion binding]; metal-binding site 530564007338 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 530564007339 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 530564007340 Ornithine acetyltransferase (OAT) family; also referred to as ArgJ. OAT catalyzes the first and fifth steps in arginine biosynthesis, coupling acetylation of glutamate with deacetylation of N-acetylornithine, which allows recycling of the acetyl group in...; Region: OAT; cd02152 530564007341 heterotetramer interface [polypeptide binding]; other site 530564007342 active site pocket [active] 530564007343 cleavage site 530564007344 Integral membrane protein TerC family; Region: TerC; cl10468 530564007345 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 530564007346 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 530564007347 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 530564007348 Hypothetical enzyme TM0436 resembles the zinc-dependent alcohol dehydrogenases (ADH); Region: MDR_TM0436_like; cd08231 530564007349 catalytic Zn binding site [ion binding]; other site 530564007350 putative phosphonate catabolism associated alcohol dehydrogenase; Region: HpnZ_proposed; TIGR03366 530564007351 structural Zn binding site [ion binding]; other site 530564007352 tetramer interface [polypeptide binding]; other site 530564007353 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 530564007354 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 530564007355 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 530564007356 CAAX protease self-immunity; Region: Abi; pfam02517 530564007357 CDP-alcohol phosphatidyltransferase; Region: CDP-OH_P_transf; cl00453 530564007358 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 530564007359 ribosomal protein S12 methylthiotransferase RimO; Region: TIGR01125 530564007360 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 530564007361 FeS/SAM binding site; other site 530564007362 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 530564007363 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 530564007364 Hexamer interface [polypeptide binding]; other site 530564007365 Hexagonal pore residue; other site 530564007366 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 530564007367 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 530564007368 Hexamer interface [polypeptide binding]; other site 530564007369 Hexagonal pore residue; other site 530564007370 Peptidase of plants and bacteria; Region: BSP; pfam04450 530564007371 Phytanoyl-CoA dioxygenase (PhyH); Region: PhyH; pfam05721 530564007372 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 530564007373 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 530564007374 phosphopeptide binding site; other site 530564007375 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 530564007376 GAF domain; Region: GAF_3; pfam13492 530564007377 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 530564007378 dimer interface [polypeptide binding]; other site 530564007379 phosphorylation site [posttranslational modification] 530564007380 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 530564007381 ATP binding site [chemical binding]; other site 530564007382 Mg2+ binding site [ion binding]; other site 530564007383 G-X-G motif; other site 530564007384 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 530564007385 active site 530564007386 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 530564007387 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564007388 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564007389 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 530564007390 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564007391 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564007392 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 530564007393 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 530564007394 catalytic residues [active] 530564007395 transcription termination factor Rho; Provisional; Region: PRK12608 530564007396 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 530564007397 RNA binding site [nucleotide binding]; other site 530564007398 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 530564007399 Walker A motif; other site 530564007400 ATP binding site [chemical binding]; other site 530564007401 Walker B motif; other site 530564007402 DinB superfamily; Region: DinB_2; pfam12867 530564007403 DinB family; Region: DinB; cl17821 530564007404 Mn-dependent transcriptional regulator [Transcription]; Region: TroR; COG1321 530564007405 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 530564007406 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 530564007407 FeoA domain; Region: FeoA; pfam04023 530564007408 N(5),N(10)-methenyltetrahydromethanopterin cyclohydrolase; Provisional; Region: PRK02264 530564007409 Methenyltetrahydromethanopterin (methenyl-H4MPT) cyclohydrolase (MCH). MCH is a cytoplasmic enzyme that has been identified in methanogenic archaea, sulfate- reducing archaea, and methylotrophic bacteria. It catalyzes the reversible formation of N(5), N...; Region: MCH; cl00249 530564007410 trimer interface I [polypeptide binding]; other site 530564007411 putative substrate binding pocket [chemical binding]; other site 530564007412 trimer interface II [polypeptide binding]; other site 530564007413 ATP-grasp enzyme, GAK system; Region: grasp_GAK; TIGR04356 530564007414 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 530564007415 ATP-grasp domain; Region: ATP-grasp_4; cl17255 530564007416 peptide synthase; Provisional; Region: PRK09274 530564007417 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_like_1; cd05910 530564007418 acyl-activating enzyme (AAE) consensus motif; other site 530564007419 putative AMP binding site [chemical binding]; other site 530564007420 putative active site [active] 530564007421 putative CoA binding site [chemical binding]; other site 530564007422 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 530564007423 Glucose dehydrogenase; Region: glucose_DH; cd08230 530564007424 NADP binding site [chemical binding]; other site 530564007425 catalytic Zn binding site [ion binding]; other site 530564007426 structural Zn binding site [ion binding]; other site 530564007427 dimer interface [polypeptide binding]; other site 530564007428 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 530564007429 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 530564007430 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 530564007431 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 530564007432 active site 530564007433 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 530564007434 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 530564007435 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 530564007436 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 530564007437 PA: Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain; Region: PA; cl08238 530564007438 M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663 530564007439 Peptidase family M28; Region: Peptidase_M28; pfam04389 530564007440 metal binding site [ion binding]; metal-binding site 530564007441 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 530564007442 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 530564007443 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 530564007444 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 530564007445 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 530564007446 Leucine Rich repeats (2 copies); Region: LRR_4; pfam12799 530564007447 NAD+ synthase (glutamine-hydrolysing); Region: PLN02339 530564007448 Glutamine aminotransferase (GAT, glutaminase) domain of glutamine-dependent NAD synthetases (class 7 and 8 nitrilases); Region: GAT_Gln-NAD-synth; cd07570 530564007449 multimer interface [polypeptide binding]; other site 530564007450 active site 530564007451 catalytic triad [active] 530564007452 protein interface 1 [polypeptide binding]; other site 530564007453 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 530564007454 homodimer interface [polypeptide binding]; other site 530564007455 NAD binding pocket [chemical binding]; other site 530564007456 ATP binding pocket [chemical binding]; other site 530564007457 Mg binding site [ion binding]; other site 530564007458 active-site loop [active] 530564007459 RF-1 domain; Region: RF-1; pfam00472 530564007460 short chain dehydrogenase; Provisional; Region: PRK07326 530564007461 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 530564007462 NAD(P) binding site [chemical binding]; other site 530564007463 active site 530564007464 Domain of unknown function (DUF309); Region: DUF309; pfam03745 530564007465 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 530564007466 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 530564007467 Serine phosphatase RsbU, regulator of sigma subunit [Signal transduction mechanisms / Transcription]; Region: RsbU; COG2208 530564007468 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 530564007469 Poly(3-hydroxybutyrate) depolymerase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: LpqC; COG3509 530564007470 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 530564007471 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14971 530564007472 Acylphosphatase; Region: Acylphosphatase; pfam00708 530564007473 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 530564007474 FOG: WD40 repeat [General function prediction only]; Region: COG2319 530564007475 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 530564007476 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 530564007477 PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal)...; Region: PDZ_signaling; cd00992 530564007478 protein binding site [polypeptide binding]; other site 530564007479 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 530564007480 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 530564007481 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 530564007482 DNA binding residues [nucleotide binding] 530564007483 glycogen synthase; Provisional; Region: glgA; PRK00654 530564007484 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 530564007485 ADP-binding pocket [chemical binding]; other site 530564007486 homodimer interface [polypeptide binding]; other site 530564007487 ADP-glucose phosphorylase; Region: PLN02643 530564007488 HIT family: HIT (Histidine triad) proteins, named for a motif related to the sequence HxHxH/Qxx (x, a hydrophobic amino acid), are a superfamily of nucleotide hydrolases and transferases, which act on the alpha-phosphate of ribonucleotides. On the basis...; Region: HIT_like; cl00228 530564007489 nucleotide binding site/active site [active] 530564007490 HIT family signature motif; other site 530564007491 catalytic residue [active] 530564007492 N-terminal catalytic domain of 4-alpha-glucanotransferase; glycoside hydrolase family 57 (GH57); Region: GH57N_TLGT_like; cd10793 530564007493 Glycosyl hydrolase family 57; Region: Glyco_hydro_57; pfam03065 530564007494 active site 530564007495 catalytic site [active] 530564007496 homodimer interface [polypeptide binding]; other site 530564007497 Lid 1; other site 530564007498 Domain of unknown function (DUF1925); Region: DUF1925; pfam09094 530564007499 Domain of unknown function (DUF1926); Region: DUF1926; pfam09095 530564007500 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 530564007501 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 530564007502 Predicted transcriptional regulator [Transcription]; Region: COG1959 530564007503 Transcriptional regulator; Region: Rrf2; pfam02082 530564007504 dithiobiotin synthetase; Reviewed; Region: bioD; PRK00090 530564007505 CobQ/CobB/MinD/ParA nucleotide binding domain; Region: CbiA; pfam01656 530564007506 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 530564007507 Catalytic domain of Protein Kinases; Region: PKc; cd00180 530564007508 active site 530564007509 ATP binding site [chemical binding]; other site 530564007510 substrate binding site [chemical binding]; other site 530564007511 activation loop (A-loop); other site 530564007512 Protein of unknown function (DUF1551); Region: DUF1551; pfam07585 530564007513 Subtilisin-like serine proteases [Posttranslational modification, protein turnover, chaperones]; Region: AprE; COG1404 530564007514 Peptidase S8 family domain in Subtilisin-like proteins; Region: Peptidases_S8_Subtilisin_like; cd07473 530564007515 catalytic triad [active] 530564007516 putative active site [active] 530564007517 Carboxypeptidase regulatory-like domain; Region: CarboxypepD_reg; pfam13620 530564007518 MoxR-like ATPases [General function prediction only]; Region: COG0714 530564007519 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564007520 Walker A motif; other site 530564007521 ATP binding site [chemical binding]; other site 530564007522 Walker B motif; other site 530564007523 arginine finger; other site 530564007524 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 530564007525 Protein of unknown function DUF58; Region: DUF58; pfam01882 530564007526 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 530564007527 metal ion-dependent adhesion site (MIDAS); other site 530564007528 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 530564007529 metal ion-dependent adhesion site (MIDAS); other site 530564007530 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 530564007531 metal ion-dependent adhesion site (MIDAS); other site 530564007532 Protein of unknown function (DUF1355); Region: DUF1355; cl17712 530564007533 MG2 domain; Region: A2M_N; pfam01835 530564007534 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 530564007535 NPCBM/NEW2 domain; Region: NPCBM; cl07060 530564007536 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 530564007537 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 530564007538 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 530564007539 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 530564007540 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 530564007541 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 530564007542 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 530564007543 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 530564007544 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 530564007545 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 530564007546 Peptidase M10 serralysin C terminal; Region: Peptidase_M10_C; pfam08548 530564007547 cyclophilin: cyclophilin-type peptidylprolyl cis- trans isomerases. This family contains eukaryotic, bacterial and archeal proteins which exhibit a peptidylprolyl cis- trans isomerases activity (PPIase, Rotamase) and in addition bind the...; Region: cyclophilin; cd00317 530564007548 active site 530564007549 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 530564007550 HAMP domain; Region: HAMP; pfam00672 530564007551 dimerization interface [polypeptide binding]; other site 530564007552 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 530564007553 dimer interface [polypeptide binding]; other site 530564007554 phosphorylation site [posttranslational modification] 530564007555 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 530564007556 ATP binding site [chemical binding]; other site 530564007557 Mg2+ binding site [ion binding]; other site 530564007558 G-X-G motif; other site 530564007559 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 530564007560 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564007561 active site 530564007562 phosphorylation site [posttranslational modification] 530564007563 intermolecular recognition site; other site 530564007564 dimerization interface [polypeptide binding]; other site 530564007565 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 530564007566 DNA binding site [nucleotide binding] 530564007567 Sulfate permease and related transporters (MFS superfamily) [Inorganic ion transport and metabolism]; Region: SUL1; COG0659 530564007568 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 530564007569 Sulfate transporter family; Region: Sulfate_transp; pfam00916 530564007570 purine nucleoside phosphorylase; Provisional; Region: PRK08202 530564007571 purine nucleoside phosphorylase; Provisional; Region: PRK08202 530564007572 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 530564007573 FOG: WD40 repeat [General function prediction only]; Region: COG2319 530564007574 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 530564007575 structural tetrad; other site 530564007576 Domain of unknown function (DUF303); Region: DUF303; pfam03629 530564007577 intracellular protease, PfpI family; Region: PfpI; TIGR01382 530564007578 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 530564007579 proposed catalytic triad [active] 530564007580 conserved cys residue [active] 530564007581 Protein of unknown function, DUF480; Region: DUF480; pfam04337 530564007582 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 530564007583 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 530564007584 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 530564007585 protein binding site [polypeptide binding]; other site 530564007586 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 530564007587 putative acyl-acceptor binding pocket; other site 530564007588 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 530564007589 iron-sulfur cluster [ion binding]; other site 530564007590 [2Fe-2S] cluster binding site [ion binding]; other site 530564007591 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 530564007592 Catalytic domain of Protein Kinases; Region: PKc; cd00180 530564007593 active site 530564007594 ATP binding site [chemical binding]; other site 530564007595 substrate binding site [chemical binding]; other site 530564007596 activation loop (A-loop); other site 530564007597 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 530564007598 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 530564007599 active site 530564007600 HIGH motif; other site 530564007601 nucleotide binding site [chemical binding]; other site 530564007602 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 530564007603 active site 530564007604 KMSKS motif; other site 530564007605 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 530564007606 tRNA binding surface [nucleotide binding]; other site 530564007607 anticodon binding site; other site 530564007608 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 530564007609 putative alpha-isopropylmalate/homocitrate synthase family transferase; Provisional; Region: PRK12344 530564007610 Desulfobacterium autotrophicum LeuA3 and related proteins, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_LeuA3; cd07941 530564007611 active site 530564007612 catalytic residues [active] 530564007613 metal binding site [ion binding]; metal-binding site 530564007614 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 530564007615 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 530564007616 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 530564007617 oligomer interface [polypeptide binding]; other site 530564007618 active site 530564007619 metal binding site [ion binding]; metal-binding site 530564007620 Protein of unknown function (DUF1625); Region: DUF1625; pfam07787 530564007621 Protein of unknown function (DUF1625); Region: DUF1625; pfam07787 530564007622 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 530564007623 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 530564007624 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 530564007625 DNA binding residues [nucleotide binding] 530564007626 MG2 domain; Region: A2M_N; pfam01835 530564007627 MG2 domain; Region: A2M_N; pfam01835 530564007628 Alpha-2-macroglobulin family; Region: A2M; pfam00207 530564007629 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 530564007630 surface patch; other site 530564007631 thioester region; other site 530564007632 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 530564007633 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 530564007634 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 530564007635 Walker A/P-loop; other site 530564007636 ATP binding site [chemical binding]; other site 530564007637 Q-loop/lid; other site 530564007638 ABC transporter signature motif; other site 530564007639 Walker B; other site 530564007640 D-loop; other site 530564007641 H-loop/switch region; other site 530564007642 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 530564007643 Ligand binding site; other site 530564007644 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 530564007645 metal-binding site 530564007646 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 530564007647 Ligand binding site; other site 530564007648 Glycosyl transferase family 8; Region: Glyco_transf_8; pfam01501 530564007649 metal-binding site 530564007650 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 530564007651 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 530564007652 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 530564007653 active site 530564007654 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 530564007655 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 530564007656 active site 530564007657 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564007658 binding surface 530564007659 TPR motif; other site 530564007660 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK06039 530564007661 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 530564007662 active site 530564007663 HIGH motif; other site 530564007664 nucleotide binding site [chemical binding]; other site 530564007665 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 530564007666 active site 530564007667 KMSKS motif; other site 530564007668 Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_ABEc; cd07961 530564007669 tRNA binding surface [nucleotide binding]; other site 530564007670 anticodon binding site; other site 530564007671 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 530564007672 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 530564007673 active site 530564007674 substrate binding site [chemical binding]; other site 530564007675 cosubstrate binding site; other site 530564007676 catalytic site [active] 530564007677 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 530564007678 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 530564007679 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 530564007680 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 530564007681 Propanediol utilisation protein PduL; Region: PduL; pfam06130 530564007682 Propanediol utilisation protein PduL; Region: PduL; pfam06130 530564007683 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 530564007684 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 530564007685 Hexamer interface [polypeptide binding]; other site 530564007686 Hexagonal pore residue; other site 530564007687 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 530564007688 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 530564007689 Hexamer interface [polypeptide binding]; other site 530564007690 Hexagonal pore residue; other site 530564007691 Acetokinase family; Region: Acetate_kinase; cl17229 530564007692 propionate/acetate kinase; Provisional; Region: PRK12379 530564007693 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 530564007694 Hexamer/Pentamer interface [polypeptide binding]; other site 530564007695 central pore; other site 530564007696 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 530564007697 putative catalytic cysteine [active] 530564007698 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 530564007699 Hexamer/Pentamer interface [polypeptide binding]; other site 530564007700 central pore; other site 530564007701 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 530564007702 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 530564007703 Hexamer/Pentamer interface [polypeptide binding]; other site 530564007704 central pore; other site 530564007705 Class II Aldolase and Adducin N-terminal domain; Region: Aldolase_II; pfam00596 530564007706 intersubunit interface [polypeptide binding]; other site 530564007707 active site 530564007708 Zn2+ binding site [ion binding]; other site 530564007709 Malate/lactate dehydrogenases [Energy production and conversion]; Region: Mdh; COG0039 530564007710 L-lactate dehydrogenase-like enzymes; Region: LDH_like; cd00300 530564007711 NAD(P) binding site [chemical binding]; other site 530564007712 dimer interface [polypeptide binding]; other site 530564007713 tetramer (dimer of dimers) interface [polypeptide binding]; other site 530564007714 substrate binding site [chemical binding]; other site 530564007715 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 530564007716 Domain of unknown function (DUF4139); Region: DUF4139; pfam13598 530564007717 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 530564007718 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 530564007719 phosphopeptide binding site; other site 530564007720 dihydroxy-acid dehydratase; Provisional; Region: PRK00911 530564007721 6-phosphogluconate dehydratase; Region: edd; TIGR01196 530564007722 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 530564007723 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 530564007724 dimer interface [polypeptide binding]; other site 530564007725 conserved gate region; other site 530564007726 putative PBP binding loops; other site 530564007727 ABC-ATPase subunit interface; other site 530564007728 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 530564007729 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 530564007730 Walker A/P-loop; other site 530564007731 ATP binding site [chemical binding]; other site 530564007732 Q-loop/lid; other site 530564007733 ABC transporter signature motif; other site 530564007734 Walker B; other site 530564007735 D-loop; other site 530564007736 H-loop/switch region; other site 530564007737 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 530564007738 Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis; Region: LPLAT; cl17185 530564007739 putative acyl-acceptor binding pocket; other site 530564007740 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564007741 DinB superfamily; Region: DinB_2; pfam12867 530564007742 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564007743 Mg-chelatase subunit ChlI [Coenzyme metabolism]; Region: ChlI; COG1239 530564007744 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 530564007745 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 530564007746 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 530564007747 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 530564007748 putative active site [active] 530564007749 heme pocket [chemical binding]; other site 530564007750 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 530564007751 dimer interface [polypeptide binding]; other site 530564007752 phosphorylation site [posttranslational modification] 530564007753 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 530564007754 ATP binding site [chemical binding]; other site 530564007755 Mg2+ binding site [ion binding]; other site 530564007756 G-X-G motif; other site 530564007757 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 530564007758 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 530564007759 HEAT repeats; Region: HEAT_2; pfam13646 530564007760 Cytochrome c, mono- and diheme variants [Energy production and conversion]; Region: CccA; COG2010 530564007761 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 530564007762 Cytochrome c; Region: Cytochrom_C; pfam00034 530564007763 hypothetical protein; Provisional; Region: PRK02227 530564007764 Putative polyhydroxyalkanoic acid system protein (PHA_gran_rgn); Region: PHA_gran_rgn; cl09865 530564007765 Predicted unusual protein kinase [General function prediction only]; Region: AarF; COG0661 530564007766 ABC1 family; Region: ABC1; cl17513 530564007767 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 530564007768 active site 530564007769 ATP binding site [chemical binding]; other site 530564007770 Response regulator receiver domain; Region: Response_reg; pfam00072 530564007771 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564007772 active site 530564007773 phosphorylation site [posttranslational modification] 530564007774 intermolecular recognition site; other site 530564007775 dimerization interface [polypeptide binding]; other site 530564007776 CheD chemotactic sensory transduction; Region: CheD; cl00810 530564007777 Chemotaxis protein CheC, inhibitor of MCP methylation [Cell motility and secretion / Signal transduction mechanisms]; Region: CheC; COG1776 530564007778 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 530564007779 putative binding surface; other site 530564007780 active site 530564007781 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 530564007782 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 530564007783 putative binding surface; other site 530564007784 active site 530564007785 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 530564007786 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 530564007787 ATP binding site [chemical binding]; other site 530564007788 Mg2+ binding site [ion binding]; other site 530564007789 G-X-G motif; other site 530564007790 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 530564007791 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 530564007792 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 530564007793 CheR methyltransferase, SAM binding domain; Region: CheR; pfam01739 530564007794 PAS domain; Region: PAS; smart00091 530564007795 PAS fold; Region: PAS; pfam00989 530564007796 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 530564007797 PAS domain; Region: PAS_9; pfam13426 530564007798 putative active site [active] 530564007799 heme pocket [chemical binding]; other site 530564007800 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 530564007801 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 530564007802 dimer interface [polypeptide binding]; other site 530564007803 putative CheW interface [polypeptide binding]; other site 530564007804 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 530564007805 putative CheA interaction surface; other site 530564007806 Response regulator receiver domain; Region: Response_reg; pfam00072 530564007807 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564007808 active site 530564007809 phosphorylation site [posttranslational modification] 530564007810 intermolecular recognition site; other site 530564007811 dimerization interface [polypeptide binding]; other site 530564007812 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564007813 binding surface 530564007814 TPR motif; other site 530564007815 TPR repeat; Region: TPR_11; pfam13414 530564007816 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 530564007817 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 530564007818 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 530564007819 Uncharacterized conserved protein [Function unknown]; Region: COG3391 530564007820 MoxR-like ATPases [General function prediction only]; Region: COG0714 530564007821 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564007822 Walker A motif; other site 530564007823 ATP binding site [chemical binding]; other site 530564007824 Walker B motif; other site 530564007825 arginine finger; other site 530564007826 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 530564007827 Protein of unknown function DUF58; Region: DUF58; pfam01882 530564007828 phosphate ABC transporter ATP-binding protein; Provisional; Region: PRK14250 530564007829 Domain of unknown function (DUF4129); Region: DUF4129; pfam13559 530564007830 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 530564007831 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 530564007832 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 530564007833 Walker A/P-loop; other site 530564007834 ATP binding site [chemical binding]; other site 530564007835 Q-loop/lid; other site 530564007836 ABC transporter signature motif; other site 530564007837 Walker B; other site 530564007838 D-loop; other site 530564007839 H-loop/switch region; other site 530564007840 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 530564007841 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564007842 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564007843 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564007844 Sulfatase; Region: Sulfatase; cl17466 530564007845 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 530564007846 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 530564007847 DNA binding residues [nucleotide binding] 530564007848 dimerization interface [polypeptide binding]; other site 530564007849 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 530564007850 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 530564007851 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 530564007852 active site 530564007853 ATP binding site [chemical binding]; other site 530564007854 substrate binding site [chemical binding]; other site 530564007855 activation loop (A-loop); other site 530564007856 FOG: WD40 repeat [General function prediction only]; Region: COG2319 530564007857 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 530564007858 structural tetrad; other site 530564007859 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 530564007860 structural tetrad; other site 530564007861 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564007862 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 530564007863 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564007864 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564007865 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 530564007866 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 530564007867 catalytic site [active] 530564007868 BNR repeat-like domain; Region: BNR_2; pfam13088 530564007869 Asp-box motif; other site 530564007870 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 530564007871 Class I aldolases; Region: Aldolase_Class_I; cl17187 530564007872 catalytic residue [active] 530564007873 Uncharacterized protein conserved in archaea (DUF2111); Region: DUF2111; cl01667 530564007874 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 530564007875 Catalytic domain of Protein Kinases; Region: PKc; cd00180 530564007876 active site 530564007877 ATP binding site [chemical binding]; other site 530564007878 substrate binding site [chemical binding]; other site 530564007879 activation loop (A-loop); other site 530564007880 Choloylglycine hydrolase (CGH) is a bile salt-modifying enzyme that hydrolyzes non-peptide carbon-nitrogen bonds in choloylglycine and choloyltaurine, both of which are present in bile. CGH is present in a number of probiotic microbial organisms that...; Region: Ntn_CGH; cd01902 530564007881 Linear amide C-N hydrolases, choloylglycine hydrolase family; Region: CBAH; pfam02275 530564007882 Response regulator receiver domain; Region: Response_reg; pfam00072 530564007883 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564007884 active site 530564007885 phosphorylation site [posttranslational modification] 530564007886 intermolecular recognition site; other site 530564007887 dimerization interface [polypeptide binding]; other site 530564007888 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 530564007889 putative binding surface; other site 530564007890 active site 530564007891 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 530564007892 putative binding surface; other site 530564007893 active site 530564007894 Chemotaxis protein histidine kinase and related kinases [Cell motility and secretion / Signal transduction mechanisms]; Region: CheA; COG0643 530564007895 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 530564007896 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 530564007897 ATP binding site [chemical binding]; other site 530564007898 Mg2+ binding site [ion binding]; other site 530564007899 G-X-G motif; other site 530564007900 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cl00256 530564007901 CheW-like domain. CheW proteins are part of the chemotaxis signalling mechanism in bacteria. CheW interacts with the methyl accepting chemotaxis proteins (MCPs) and relays signals to CheY, which affects flageller rotation. This family includes CheW and...; Region: CheW_like; cd00588 530564007902 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 530564007903 putative CheA interaction surface; other site 530564007904 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 530564007905 dimerization interface [polypeptide binding]; other site 530564007906 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 530564007907 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 530564007908 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 530564007909 dimer interface [polypeptide binding]; other site 530564007910 putative CheW interface [polypeptide binding]; other site 530564007911 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564007912 Response regulator receiver domain; Region: Response_reg; pfam00072 530564007913 active site 530564007914 phosphorylation site [posttranslational modification] 530564007915 intermolecular recognition site; other site 530564007916 dimerization interface [polypeptide binding]; other site 530564007917 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 530564007918 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564007919 active site 530564007920 phosphorylation site [posttranslational modification] 530564007921 intermolecular recognition site; other site 530564007922 dimerization interface [polypeptide binding]; other site 530564007923 CheB methylesterase; Region: CheB_methylest; pfam01339 530564007924 Methylase of chemotaxis methyl-accepting proteins [Cell motility and secretion / Signal transduction mechanisms]; Region: CheR; COG1352 530564007925 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 530564007926 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 530564007927 S-adenosylmethionine binding site [chemical binding]; other site 530564007928 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 530564007929 Predicted glycosyltransferases [General function prediction only]; Region: COG1216 530564007930 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 530564007931 active site 530564007932 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 530564007933 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564007934 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564007935 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564007936 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 530564007937 Ribonuclease D [Translation, ribosomal structure and biogenesis]; Region: Rnd; COG0349 530564007938 catalytic site [active] 530564007939 putative active site [active] 530564007940 putative substrate binding site [chemical binding]; other site 530564007941 HRDC domain; Region: HRDC; pfam00570 530564007942 BtpA family; Region: BtpA; cl00440 530564007943 rRNA methylases [Translation, ribosomal structure and biogenesis]; Region: SpoU; COG0566 530564007944 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 530564007945 Membrane transporters of cations and cationic drugs [Inorganic ion transport and metabolism]; Region: EmrE; COG2076 530564007946 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564007947 AAA domain; Region: AAA_22; pfam13401 530564007948 Walker A motif; other site 530564007949 ATP binding site [chemical binding]; other site 530564007950 Walker B motif; other site 530564007951 arginine finger; other site 530564007952 16S ribosomal RNA methyltransferase RsmE; Provisional; Region: PRK11713 530564007953 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564007954 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 530564007955 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564007956 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564007957 CARDB; Region: CARDB; pfam07705 530564007958 Predicted membrane protein [Function unknown]; Region: COG1470 530564007959 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 530564007960 Ligand Binding Site [chemical binding]; other site 530564007961 putative TIM-barrel protein, nifR3 family; Region: nifR3_yhdG; TIGR00737 530564007962 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 530564007963 FMN binding site [chemical binding]; other site 530564007964 active site 530564007965 catalytic residues [active] 530564007966 substrate binding site [chemical binding]; other site 530564007967 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 530564007968 Trp docking motif [polypeptide binding]; other site 530564007969 PQQ-like domain; Region: PQQ_2; pfam13360 530564007970 active site 530564007971 ABC1 family; Region: ABC1; cl17513 530564007972 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 530564007973 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 530564007974 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 530564007975 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 530564007976 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 530564007977 G1 box; other site 530564007978 putative GEF interaction site [polypeptide binding]; other site 530564007979 GTP/Mg2+ binding site [chemical binding]; other site 530564007980 Switch I region; other site 530564007981 G2 box; other site 530564007982 G3 box; other site 530564007983 Switch II region; other site 530564007984 G4 box; other site 530564007985 G5 box; other site 530564007986 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 530564007987 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 530564007988 Tudor domains are found in many eukaryotic organisms and have been implicated in protein-protein interactions in which methylated protein substrates bind to these domains. For example, the Tudor domain of Survival of Motor Neuron (SMN) binds to...; Region: TUDOR; cl02573 530564007989 Protein of unknown function (DUF3050); Region: DUF3050; pfam11251 530564007990 C-20 methyltransferase BchU; Region: C20_methyl_CrtF; TIGR02716 530564007991 O-methyltransferase; Region: Methyltransf_2; pfam00891 530564007992 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 530564007993 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 530564007994 D-alanyl-alanine synthetase A; Provisional; Region: PRK14571 530564007995 ATP-grasp domain; Region: ATP-grasp_4; cl17255 530564007996 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 530564007997 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 530564007998 Coenzyme A binding pocket [chemical binding]; other site 530564007999 D-alanine-D-alanine ligase and related ATP-grasp enzymes [Cell envelope biogenesis, outer membrane]; Region: DdlA; COG1181 530564008000 ATP-grasp domain; Region: ATP-grasp_4; cl17255 530564008001 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 530564008002 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 530564008003 FeS/SAM binding site; other site 530564008004 Lysine-2,3-aminomutase; Region: LAM_C; pfam12544 530564008005 folate/biopterin transporter; Region: fbt; TIGR00788 530564008006 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 530564008007 Cysteine-rich domain; Region: CCG; pfam02754 530564008008 Cysteine-rich domain; Region: CCG; pfam02754 530564008009 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 530564008010 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 530564008011 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 530564008012 Peptidase family M41; Region: Peptidase_M41; pfam01434 530564008013 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 530564008014 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 530564008015 G1 box; other site 530564008016 putative GEF interaction site [polypeptide binding]; other site 530564008017 GTP/Mg2+ binding site [chemical binding]; other site 530564008018 Switch I region; other site 530564008019 G2 box; other site 530564008020 G3 box; other site 530564008021 Switch II region; other site 530564008022 G4 box; other site 530564008023 G5 box; other site 530564008024 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 530564008025 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 530564008026 active site 530564008027 PQQ-like domain; Region: PQQ_2; pfam13360 530564008028 Trp docking motif [polypeptide binding]; other site 530564008029 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 530564008030 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 530564008031 active site 530564008032 ATP binding site [chemical binding]; other site 530564008033 substrate binding site [chemical binding]; other site 530564008034 activation loop (A-loop); other site 530564008035 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 530564008036 putative active site pocket [active] 530564008037 dimerization interface [polypeptide binding]; other site 530564008038 putative catalytic residue [active] 530564008039 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 530564008040 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 530564008041 RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984 530564008042 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 530564008043 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 530564008044 DNA binding residues [nucleotide binding] 530564008045 sulfite oxidase; Provisional; Region: PLN00177 530564008046 Subgroup of sulfite oxidase (SO) family molybdopterin binding domains that contains conserved dimerization domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate...; Region: SO_family_Moco_dimer; cd02110 530564008047 Moco binding site; other site 530564008048 metal coordination site [ion binding]; other site 530564008049 dimerization interface [polypeptide binding]; other site 530564008050 DinB superfamily; Region: DinB_2; pfam12867 530564008051 Response regulator receiver domain; Region: Response_reg; pfam00072 530564008052 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564008053 active site 530564008054 phosphorylation site [posttranslational modification] 530564008055 intermolecular recognition site; other site 530564008056 dimerization interface [polypeptide binding]; other site 530564008057 M28 Zn-Peptidases containing a PA domain insert and associated with a PDZ domain; Region: M28_like_PA_PDZ_associated; cd05663 530564008058 Peptidase family M28; Region: Peptidase_M28; pfam04389 530564008059 metal binding site [ion binding]; metal-binding site 530564008060 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 530564008061 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 530564008062 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 530564008063 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564008064 Walker A motif; other site 530564008065 ATP binding site [chemical binding]; other site 530564008066 EVE domain; Region: EVE; cl00728 530564008067 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 530564008068 McrBC 5-methylcytosine restriction system component; Region: McrBC; cl01737 530564008069 PD-(D/E)XK nuclease superfamily; Region: PDDEXK_1; pfam12705 530564008070 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cl17512 530564008071 beta-clamp/translesion DNA polymerase binding surface; other site 530564008072 beta-clamp/clamp loader binding surface; other site 530564008073 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564008074 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 530564008075 Walker A motif; other site 530564008076 ATP binding site [chemical binding]; other site 530564008077 Walker B motif; other site 530564008078 arginine finger; other site 530564008079 Protein of unknown function (DUF2997); Region: DUF2997; pfam11211 530564008080 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 530564008081 HSP70 interaction site [polypeptide binding]; other site 530564008082 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 530564008083 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 530564008084 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 530564008085 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 530564008086 ATP binding site [chemical binding]; other site 530564008087 putative Mg++ binding site [ion binding]; other site 530564008088 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 530564008089 nucleotide binding region [chemical binding]; other site 530564008090 ATP-binding site [chemical binding]; other site 530564008091 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 530564008092 Superfamily of nucleases including Short Patch Repair (Vsr) Endonucleases, archaeal Holliday junction resolvases, MutH methy-directed DNA mismatch-repair endonucleases, and catalytic domains of many restriction endonucleases, such as EcoRI, BamHI, and...; Region: Restriction_endonuclease_like; cl00277 530564008093 putative active site [active] 530564008094 Part of AAA domain; Region: AAA_19; pfam13245 530564008095 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 530564008096 Family description; Region: UvrD_C_2; pfam13538 530564008097 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 530564008098 ATP binding site [chemical binding]; other site 530564008099 putative Mg++ binding site [ion binding]; other site 530564008100 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 530564008101 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 530564008102 nucleotide binding region [chemical binding]; other site 530564008103 ATP-binding site [chemical binding]; other site 530564008104 Methyltransferase domain; Region: Methyltransf_26; pfam13659 530564008105 Predicted ATPase [General function prediction only]; Region: COG5293 530564008106 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 530564008107 Domain of unknown function (DUF4365); Region: DUF4365; pfam14280 530564008108 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 530564008109 RT_Bac_retron_I: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_I; cd01646 530564008110 putative active site [active] 530564008111 putative NTP binding site [chemical binding]; other site 530564008112 putative nucleic acid binding site [nucleotide binding]; other site 530564008113 Piwi-like: PIWI domain. Domain found in proteins involved in RNA silencing. RNA silencing refers to a group of related gene-silencing mechanisms mediated by short RNA molecules, including siRNAs, miRNAs, and heterochromatin-related guide RNAs. The...; Region: Piwi-like; cl00628 530564008114 5' RNA guide strand anchoring site; other site 530564008115 active site 530564008116 SIR2-like domain; Region: SIR2_2; pfam13289 530564008117 ergothioneine biosynthesis protein EgtC; Region: TIGR03442 530564008118 Divergent AAA domain; Region: AAA_4; pfam04326 530564008119 TspO/MBR family; Region: TspO_MBR; pfam03073 530564008120 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564008121 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 530564008122 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564008123 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564008124 Transcriptional regulators [Transcription]; Region: FadR; COG2186 530564008125 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 530564008126 DNA-binding site [nucleotide binding]; DNA binding site 530564008127 FCD domain; Region: FCD; pfam07729 530564008128 RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984 530564008129 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 530564008130 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 530564008131 DNA binding residues [nucleotide binding] 530564008132 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 530564008133 Catalytic domain of Protein Kinases; Region: PKc; cd00180 530564008134 active site 530564008135 ATP binding site [chemical binding]; other site 530564008136 substrate binding site [chemical binding]; other site 530564008137 activation loop (A-loop); other site 530564008138 CotH protein; Region: CotH; pfam08757 530564008139 Polyphosphate(polyP) polymerase domain of yeast vacuolar transport chaperone (VTC) proteins VTC-2, -3 and- 4, and similar proteins; Region: PolyPPase_VTC_like; cd07750 530564008140 dimer interface [polypeptide binding]; other site 530564008141 putative metal binding residues [ion binding]; other site 530564008142 signature motif; other site 530564008143 active site 530564008144 polyP binding site; other site 530564008145 substrate binding site [chemical binding]; other site 530564008146 acceptor-phosphate pocket; other site 530564008147 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 530564008148 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 530564008149 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 530564008150 MafB19-like deaminase; Region: MafB19-deam; pfam14437 530564008151 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 530564008152 S-adenosylmethionine binding site [chemical binding]; other site 530564008153 DsrE/DsrF-like family; Region: DrsE; pfam02635 530564008154 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 530564008155 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 530564008156 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 530564008157 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 530564008158 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 530564008159 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 530564008160 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 530564008161 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 530564008162 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 530564008163 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 530564008164 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 530564008165 active site 530564008166 catalytic tetrad [active] 530564008167 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564008168 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 530564008169 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564008170 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564008171 Calcium/calmodulin dependent protein kinase II Association; Region: CaMKII_AD; cl17504 530564008172 pilus retraction protein PilT; Region: pilT_fam; TIGR01420 530564008173 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 530564008174 Walker A motif; other site 530564008175 ATP binding site [chemical binding]; other site 530564008176 Walker B motif; other site 530564008177 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 530564008178 anti sigma factor interaction site; other site 530564008179 regulatory phosphorylation site [posttranslational modification]; other site 530564008180 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 530564008181 Beta-lactamase; Region: Beta-lactamase; pfam00144 530564008182 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 530564008183 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 530564008184 Putative esterase; Region: Esterase; pfam00756 530564008185 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 530564008186 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3295 530564008187 PepSY-associated TM helix; Region: PepSY_TM_1; pfam13172 530564008188 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 530564008189 ApbE family; Region: ApbE; pfam02424 530564008190 Predicted periplasmic protein (DUF2271); Region: DUF2271; pfam10029 530564008191 Kelch domain; Region: Kelch; smart00612 530564008192 Kelch motif; Region: Kelch_1; pfam01344 530564008193 Kelch domain; Region: Kelch; smart00612 530564008194 Kelch motif; Region: Kelch_1; pfam01344 530564008195 Kelch motif; Region: Kelch_1; pfam01344 530564008196 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 530564008197 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 530564008198 Cytochrome c; Region: Cytochrom_C; pfam00034 530564008199 Putative peptidase family; Region: Metallopep; pfam12044 530564008200 Pregnancy-associated plasma protein-A; Region: Peptidase_M43; cl17409 530564008201 NPCBM/NEW2 domain; Region: NPCBM; pfam08305 530564008202 TupA-like ATPgrasp; Region: ATPgrasp_TupA; pfam14305 530564008203 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 530564008204 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 530564008205 FOG: WD40 repeat [General function prediction only]; Region: COG2319 530564008206 structural tetrad; other site 530564008207 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564008208 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564008209 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564008210 LssY C-terminus; Region: LssY_C; pfam14067 530564008211 Domain of unknown function (DUF303); Region: DUF303; pfam03629 530564008212 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564008213 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; cl17415 530564008214 Transcriptional regulators [Transcription]; Region: GntR; COG1802 530564008215 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 530564008216 DNA-binding site [nucleotide binding]; DNA binding site 530564008217 FCD domain; Region: FCD; pfam07729 530564008218 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 530564008219 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 530564008220 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 530564008221 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 530564008222 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 530564008223 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 530564008224 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 530564008225 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 530564008226 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564008227 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564008228 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564008229 Sulfatase; Region: Sulfatase; cl17466 530564008230 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 530564008231 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564008232 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564008233 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564008234 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 530564008235 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 530564008236 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 530564008237 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 530564008238 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 530564008239 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 530564008240 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 530564008241 Antagonist of mitotic exit network protein 1; Region: AMN1; cl15308 530564008242 Protein of unknown function (DUF1552); Region: HXXSHH; pfam07586 530564008243 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 530564008244 Protein of unknown function (DUF1587); Region: PSD3; pfam07626 530564008245 Protein of unknown function (DUF1595); Region: PSD5; pfam07637 530564008246 Protein of unknown function (DUF1592); Region: PSD4; pfam07631 530564008247 Protein of unknown function (DUF1588); Region: PSCyt3; pfam07627 530564008248 Protein of unknown function (DUF1585); Region: PSD2; pfam07624 530564008249 RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989 530564008250 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 530564008251 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 530564008252 Beta-lactamase; Region: Beta-lactamase; pfam00144 530564008253 Family description; Region: DsbD_2; pfam13386 530564008254 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 530564008255 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 530564008256 Soluble P-type ATPase [General function prediction only]; Region: COG4087 530564008257 Cytochrome C oxidase, mono-heme subunit/FixO; Region: FixO; cl01130 530564008258 Heme-copper oxidase subunit I. Heme-copper oxidases are transmembrane protein complexes in the respiratory chains of prokaryotes and mitochondria which catalyze the reduction of O2 and simultaneously pump protons across the membrane. The superfamily is...; Region: Heme_Cu_Oxidase_I; cl00275 530564008259 Low-spin heme binding site [chemical binding]; other site 530564008260 Cytochrome C and Quinol oxidase polypeptide I; Region: COX1; pfam00115 530564008261 D-pathway; other site 530564008262 Putative water exit pathway; other site 530564008263 Binuclear center (active site) [active] 530564008264 K-pathway; other site 530564008265 Putative proton exit pathway; other site 530564008266 putative bifunctional cbb3-type cytochrome c oxidase subunit II/cytochrome c; Provisional; Region: PRK14486 530564008267 Cytochrome c; Region: Cytochrom_C; pfam00034 530564008268 Uncharacterized conserved protein [Function unknown]; Region: COG5649 530564008269 Uncharacterized conserved protein [Function unknown]; Region: COG5649 530564008270 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 530564008271 putative hydrophobic ligand binding site [chemical binding]; other site 530564008272 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cl14643 530564008273 hydrophobic ligand binding site; other site 530564008274 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 530564008275 putative DNA binding site [nucleotide binding]; other site 530564008276 putative Zn2+ binding site [ion binding]; other site 530564008277 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 530564008278 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 530564008279 Cupin domain; Region: Cupin_2; pfam07883 530564008280 Predicted epimerase, PhzC/PhzF homolog [General function prediction only]; Region: COG0384 530564008281 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 530564008282 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 530564008283 decaheme c-type cytochrome, DmsE family; Region: decahem_SO; TIGR03508 530564008284 Heme-binding domain of the class III cytochrome C family and related proteins; Region: Cytochrom_C3; cd08168 530564008285 heme-binding residues [chemical binding]; other site 530564008286 HEAT repeats; Region: HEAT_2; pfam13646 530564008287 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564008288 binding surface 530564008289 TPR motif; other site 530564008290 Predicted phosphoesterase (MutT family) [General function prediction only]; Region: COG4112 530564008291 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 530564008292 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 530564008293 metal-binding site [ion binding] 530564008294 Cation transport ATPase [Inorganic ion transport and metabolism]; Region: ZntA; COG2217 530564008295 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 530564008296 metal-binding site [ion binding] 530564008297 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 530564008298 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 530564008299 motif II; other site 530564008300 competence damage-inducible protein A; Provisional; Region: PRK00549 530564008301 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 530564008302 putative MPT binding site; other site 530564008303 Competence-damaged protein; Region: CinA; cl00666 530564008304 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 530564008305 FOG: WD40 repeat [General function prediction only]; Region: COG2319 530564008306 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 530564008307 structural tetrad; other site 530564008308 FOG: WD40 repeat [General function prediction only]; Region: COG2319 530564008309 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 530564008310 structural tetrad; other site 530564008311 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 530564008312 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564008313 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564008314 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 530564008315 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 530564008316 active site 530564008317 interdomain interaction site; other site 530564008318 putative metal-binding site [ion binding]; other site 530564008319 nucleotide binding site [chemical binding]; other site 530564008320 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 530564008321 domain I; other site 530564008322 DNA binding groove [nucleotide binding] 530564008323 phosphate binding site [ion binding]; other site 530564008324 domain II; other site 530564008325 domain III; other site 530564008326 nucleotide binding site [chemical binding]; other site 530564008327 catalytic site [active] 530564008328 domain IV; other site 530564008329 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 530564008330 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 530564008331 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 530564008332 Topoisomerase C-terminal repeat; Region: Toprim_C_rpt; pfam13368 530564008333 4'-phosphopantetheinyl transferase; Provisional; Region: acpS; PRK00070 530564008334 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 530564008335 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 530564008336 dimer interface [polypeptide binding]; other site 530564008337 phosphorylation site [posttranslational modification] 530564008338 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 530564008339 ATP binding site [chemical binding]; other site 530564008340 G-X-G motif; other site 530564008341 Peptidase family M1; Region: Peptidase_M1; pfam01433 530564008342 Peptidase M1 family Aminopeptidase N; Region: M1_APN_4; cd09603 530564008343 Zn binding site [ion binding]; other site 530564008344 HEAT repeats; Region: HEAT_2; pfam13646 530564008345 HEAT repeats; Region: HEAT_2; pfam13646 530564008346 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 530564008347 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 530564008348 putative metal binding site [ion binding]; other site 530564008349 DisA bacterial checkpoint controller nucleotide-binding; Region: DisA_N; pfam02457 530564008350 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 530564008351 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 530564008352 Coenzyme A binding pocket [chemical binding]; other site 530564008353 YjeF-related protein N-terminus; Region: YjeF_N; pfam03853 530564008354 putative regulatory protein, FmdB family; Region: CxxC_CxxC_SSSS; TIGR02605 530564008355 Domain of unknown function (DUF2007); Region: DUF2007; pfam09413 530564008356 CHAD domain; Region: CHAD; pfam05235 530564008357 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 530564008358 catalytic core [active] 530564008359 polyphosphate kinase; Provisional; Region: PRK05443 530564008360 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 530564008361 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 530564008362 Catalytic C-terminal domain, first repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C1_like; cd09165 530564008363 putative domain interface [polypeptide binding]; other site 530564008364 putative active site [active] 530564008365 catalytic site [active] 530564008366 Catalytic C-terminal domain, second repeat, of Pseudomonas aeruginosa polyphosphate kinase 1 and similar proteins; Region: PLDc_PaPPK1_C2_like; cd09168 530564008367 putative domain interface [polypeptide binding]; other site 530564008368 putative active site [active] 530564008369 catalytic site [active] 530564008370 Exopolyphosphatase [Nucleotide transport and metabolism / Inorganic ion transport and metabolism]; Region: GppA; COG0248 530564008371 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 530564008372 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 530564008373 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 530564008374 nucleotide binding site [chemical binding]; other site 530564008375 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564008376 TPR motif; other site 530564008377 TPR repeat; Region: TPR_11; pfam13414 530564008378 binding surface 530564008379 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564008380 TPR motif; other site 530564008381 binding surface 530564008382 Tetratricopeptide repeat; Region: TPR_16; pfam13432 530564008383 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564008384 TPR motif; other site 530564008385 Tetratricopeptide repeat; Region: TPR_16; pfam13432 530564008386 binding surface 530564008387 Tetratricopeptide repeat; Region: TPR_12; pfam13424 530564008388 hypothetical protein; Provisional; Region: PRK07208 530564008389 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 530564008390 Predicted membrane protein [Function unknown]; Region: COG2246 530564008391 GtrA-like protein; Region: GtrA; pfam04138 530564008392 RNA polymerase sigma factor, FliA/WhiG family; Region: FliA_WhiG; TIGR02479 530564008393 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 530564008394 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 530564008395 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 530564008396 DNA binding residues [nucleotide binding] 530564008397 Antiactivator of flagellar biosynthesis FleN, an ATPase [Cell motility]; Region: flhG; COG0455 530564008398 FleN is a member of the Fer4_NifH superfamily. It shares the common function as an ATPase, with the ATP-binding domain at the N-terminus. In Pseudomonas aeruginosa, FleN gene is involved in regulating the number of flagella and chemotactic motility by...; Region: FleN-like; cd02038 530564008399 flagellar biosynthesis regulator FlhF; Validated; Region: flhF; PRK05703 530564008400 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 530564008401 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 530564008402 FHIPEP family; Region: FHIPEP; pfam00771 530564008403 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: DUF374; Region: LPLAT_DUF374-like; cd07983 530564008404 putative acyl-acceptor binding pocket; other site 530564008405 Predicted hydrolase (HAD superfamily) [General function prediction only]; Region: COG1011 530564008406 REG-2-like, HAD superfamily (subfamily IA) hydrolase; Region: DREG-2; TIGR02252 530564008407 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 530564008408 active site 530564008409 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 530564008410 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 530564008411 RIP metalloprotease RseP; Region: TIGR00054 530564008412 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 530564008413 putative substrate binding region [chemical binding]; other site 530564008414 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 530564008415 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 530564008416 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 530564008417 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 530564008418 ATP-dependent metalloprotease FtsH; Region: FtsH_fam; TIGR01241 530564008419 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564008420 Walker A motif; other site 530564008421 ATP binding site [chemical binding]; other site 530564008422 Walker B motif; other site 530564008423 arginine finger; other site 530564008424 Peptidase family M41; Region: Peptidase_M41; pfam01434 530564008425 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 530564008426 Chain length determinant protein; Region: Wzz; pfam02706 530564008427 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 530564008428 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 530564008429 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 530564008430 Nitrogen regulatory protein P-II; Region: P-II; smart00938 530564008431 Glutamine synthetase adenylyltransferase [Posttranslational modification, protein turnover, chaperones / Signal transduction mechanisms]; Region: GlnE; COG1391 530564008432 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 530564008433 metal binding triad; other site 530564008434 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 530564008435 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 530564008436 metal binding triad; other site 530564008437 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 530564008438 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 530564008439 RNA polymerase sigma factor RpoD, C-terminal domain; Region: RpoD_Cterm; TIGR02393 530564008440 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 530564008441 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 530564008442 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 530564008443 DNA binding residues [nucleotide binding] 530564008444 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK05565 530564008445 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 530564008446 NAD(P) binding site [chemical binding]; other site 530564008447 active site 530564008448 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 530564008449 S-adenosylmethionine binding site [chemical binding]; other site 530564008450 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 530564008451 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 530564008452 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 530564008453 HlyD family secretion protein; Region: HlyD_3; pfam13437 530564008454 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 530564008455 MarR family; Region: MarR_2; pfam12802 530564008456 GTP-binding protein HflX; Region: GTP_HflX; TIGR03156 530564008457 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 530564008458 HflX GTPase family; Region: HflX; cd01878 530564008459 G1 box; other site 530564008460 GTP/Mg2+ binding site [chemical binding]; other site 530564008461 Switch I region; other site 530564008462 G2 box; other site 530564008463 G3 box; other site 530564008464 Switch II region; other site 530564008465 G4 box; other site 530564008466 G5 box; other site 530564008467 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 530564008468 short chain dehydrogenase; Provisional; Region: PRK06181 530564008469 NAD(P) binding site [chemical binding]; other site 530564008470 active site 530564008471 Pilus formation protein N terminal region; Region: T2SS-T3SS_pil_N; pfam13629 530564008472 Flp pilus assembly protein, secretin CpaC [Intracellular trafficking and secretion]; Region: CpaC; COG4964 530564008473 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 530564008474 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564008475 binding surface 530564008476 TPR motif; other site 530564008477 TPR repeat; Region: TPR_11; pfam13414 530564008478 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564008479 TPR motif; other site 530564008480 binding surface 530564008481 TPR repeat; Region: TPR_11; pfam13414 530564008482 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 530564008483 Holliday junction resolvase; Reviewed; Region: ruvC; PRK00039 530564008484 active site 530564008485 putative DNA-binding cleft [nucleotide binding]; other site 530564008486 dimer interface [polypeptide binding]; other site 530564008487 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 530564008488 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 530564008489 active site 530564008490 HIGH motif; other site 530564008491 nucleotide binding site [chemical binding]; other site 530564008492 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 530564008493 active site 530564008494 KMSKS motif; other site 530564008495 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 530564008496 tRNA binding surface [nucleotide binding]; other site 530564008497 anticodon binding site; other site 530564008498 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 530564008499 homotrimer interaction site [polypeptide binding]; other site 530564008500 zinc binding site [ion binding]; other site 530564008501 CDP-binding sites; other site 530564008502 ATP-grasp domain; Region: ATP-grasp_4; cl17255 530564008503 Predicted transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: COG1548; cl00668 530564008504 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 530564008505 nucleotide binding site [chemical binding]; other site 530564008506 substrate binding site [chemical binding]; other site 530564008507 Protein of unknown function (DUF1598); Region: DUF1598; pfam07643 530564008508 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 530564008509 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 530564008510 phosphopeptide binding site; other site 530564008511 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 530564008512 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 530564008513 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 530564008514 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564008515 Walker A motif; other site 530564008516 ATP binding site [chemical binding]; other site 530564008517 Walker B motif; other site 530564008518 arginine finger; other site 530564008519 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 530564008520 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 530564008521 GT_2_like_a represents a glycosyltransferase family-2 subfamily with unknown function; Region: GT_2_like_a; cd02522 530564008522 transferase 2, rSAM/selenodomain-associated; Region: glyco_like_mftF; TIGR04283 530564008523 Probable Catalytic site; other site 530564008524 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 530564008525 catalytic residues [active] 530564008526 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 530564008527 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 530564008528 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564008529 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 530564008530 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 530564008531 putative acyl-acceptor binding pocket; other site 530564008532 cytidylate kinase; Provisional; Region: cmk; PRK00023 530564008533 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 530564008534 CMP-binding site; other site 530564008535 The sites determining sugar specificity; other site 530564008536 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 530564008537 Domain of unknown function (DUF4303); Region: DUF4303; pfam14136 530564008538 TPR repeat; Region: TPR_11; pfam13414 530564008539 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564008540 TPR motif; other site 530564008541 binding surface 530564008542 TPR repeat; Region: TPR_11; pfam13414 530564008543 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564008544 TPR motif; other site 530564008545 binding surface 530564008546 type IV pilus assembly protein PilM; Region: pilM; TIGR01175 530564008547 Cell division protein FtsA; Region: FtsA; pfam14450 530564008548 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 530564008549 active site 530564008550 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 530564008551 HEAT repeats; Region: HEAT_2; pfam13646 530564008552 oxidoreductase alpha (molybdopterin) subunit; Region: Fdhalpha-like; TIGR01701 530564008553 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 530564008554 molybdopterin cofactor binding site; other site 530564008555 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 530564008556 putative molybdopterin cofactor binding site; other site 530564008557 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 530564008558 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 530564008559 Domain of unknown function DUF20; Region: UPF0118; pfam01594 530564008560 Protein of unknown function (DUF4237); Region: DUF4237; pfam14021 530564008561 Phosphopantetheine attachment site; Region: PP-binding; cl09936 530564008562 Uncharacterized conserved protein [Function unknown]; Region: COG4717 530564008563 arogenate dehydrogenase; Region: PLN02256 530564008564 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 530564008565 active site 530564008566 metal binding site [ion binding]; metal-binding site 530564008567 DNA binding site [nucleotide binding] 530564008568 Nicotinate-nucleotide pyrophosphorylase [Coenzyme metabolism]; Region: NadC; COG0157 530564008569 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 530564008570 dimerization interface [polypeptide binding]; other site 530564008571 active site 530564008572 Type II secretory pathway, pseudopilin PulG [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulG; COG2165 530564008573 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 530564008574 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 530564008575 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 530564008576 nucleotide binding site [chemical binding]; other site 530564008577 Pilus assembly protein, PilO; Region: PilO; cl01234 530564008578 type IV pilus secretin (or competence protein) PilQ; Region: IV_pilus_PilQ; TIGR02515 530564008579 Secretin and TonB N terminus short domain; Region: STN; pfam07660 530564008580 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 530564008581 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 530564008582 PAS domain; Region: PAS; smart00091 530564008583 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 530564008584 dimer interface [polypeptide binding]; other site 530564008585 phosphorylation site [posttranslational modification] 530564008586 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 530564008587 ATP binding site [chemical binding]; other site 530564008588 Mg2+ binding site [ion binding]; other site 530564008589 G-X-G motif; other site 530564008590 Response regulator receiver domain; Region: Response_reg; pfam00072 530564008591 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564008592 active site 530564008593 phosphorylation site [posttranslational modification] 530564008594 intermolecular recognition site; other site 530564008595 dimerization interface [polypeptide binding]; other site 530564008596 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 530564008597 anti sigma factor interaction site; other site 530564008598 regulatory phosphorylation site [posttranslational modification]; other site 530564008599 type IV-A pilus assembly ATPase PilB; Region: type_IV_pilB; TIGR02538 530564008600 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 530564008601 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 530564008602 Walker A motif; other site 530564008603 ATP binding site [chemical binding]; other site 530564008604 Walker B motif; other site 530564008605 Type II secretory pathway, component PulF [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulF; COG1459 530564008606 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 530564008607 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 530564008608 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 530564008609 Predicted Fe-S oxidoreductase [General function prediction only]; Region: COG1242 530564008610 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 530564008611 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 530564008612 phosphopeptide binding site; other site 530564008613 Stress responsive A/B Barrel Domain; Region: Dabb; pfam07876 530564008614 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 530564008615 Sulfatase; Region: Sulfatase; pfam00884 530564008616 Global regulator protein family; Region: CsrA; pfam02599 530564008617 UvrB/uvrC motif; Region: UVR; pfam02151 530564008618 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 530564008619 cyclohexanecarboxyl-CoA dehydrogenase; Region: cyc_hxne_CoA_dh; TIGR03207 530564008620 active site 530564008621 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 530564008622 dimer interface [polypeptide binding]; other site 530564008623 phosphorylation site [posttranslational modification] 530564008624 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 530564008625 ATP binding site [chemical binding]; other site 530564008626 G-X-G motif; other site 530564008627 Cys/Met metabolism PLP-dependent enzyme; Region: Cys_Met_Meta_PP; pfam01053 530564008628 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 530564008629 homodimer interface [polypeptide binding]; other site 530564008630 substrate-cofactor binding pocket; other site 530564008631 pyridoxal 5'-phosphate binding site [chemical binding]; other site 530564008632 catalytic residue [active] 530564008633 Cystathionine beta-lyases/cystathionine gamma-synthases [Amino acid transport and metabolism]; Region: MetC; COG0626 530564008634 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 530564008635 homodimer interface [polypeptide binding]; other site 530564008636 substrate-cofactor binding pocket; other site 530564008637 pyridoxal 5'-phosphate binding site [chemical binding]; other site 530564008638 catalytic residue [active] 530564008639 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 530564008640 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 530564008641 Ligand Binding Site [chemical binding]; other site 530564008642 ribonuclease III; Reviewed; Region: rnc; PRK00102 530564008643 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 530564008644 dimerization interface [polypeptide binding]; other site 530564008645 active site 530564008646 metal binding site [ion binding]; metal-binding site 530564008647 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 530564008648 dsRNA binding site [nucleotide binding]; other site 530564008649 Putative D-isomer specific 2-hydroxyacid dehydrogenase; Region: 2-Hacid_dh_1; cd05300 530564008650 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 530564008651 NAD binding site [chemical binding]; other site 530564008652 ligand binding site [chemical binding]; other site 530564008653 catalytic site [active] 530564008654 BON domain; Region: BON; pfam04972 530564008655 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 530564008656 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 530564008657 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 530564008658 pilus (MSHA type) biogenesis protein MshL; Region: pilus_MshL; TIGR02519 530564008659 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 530564008660 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 530564008661 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 530564008662 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 530564008663 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 530564008664 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 530564008665 type II secretion system protein F; Region: GspF; TIGR02120 530564008666 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 530564008667 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 530564008668 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 530564008669 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 530564008670 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 530564008671 Walker A motif; other site 530564008672 ATP binding site [chemical binding]; other site 530564008673 Walker B motif; other site 530564008674 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; cl17364 530564008675 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 530564008676 Alpha-L-rhamnosidase N-terminal domain; Region: Bac_rhamnosid_N; pfam08531 530564008677 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 530564008678 HEAT repeats; Region: HEAT_2; pfam13646 530564008679 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 530564008680 Cytochrome c; Region: Cytochrom_C; pfam00034 530564008681 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 530564008682 Sulfatase; Region: Sulfatase; pfam00884 530564008683 HDOD domain; Region: HDOD; pfam08668 530564008684 Predicted ATPase with chaperone activity [Posttranslational modification, protein turnover, chaperones]; Region: COG0606 530564008685 Ubiquitin-like proteins; Region: UBQ; cl00155 530564008686 charged pocket; other site 530564008687 hydrophobic patch; other site 530564008688 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 530564008689 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; smart01008 530564008690 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 530564008691 Aerobic-type carbon monoxide dehydrogenase, small subunit CoxS/CutS homologs [Energy production and conversion]; Region: CoxS; COG2080 530564008692 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 530564008693 catalytic loop [active] 530564008694 iron binding site [ion binding]; other site 530564008695 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 530564008696 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 530564008697 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 530564008698 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 530564008699 trimer interface [polypeptide binding]; other site 530564008700 active site 530564008701 Predicted EndoIII-related endonuclease [DNA replication, recombination, and repair]; Region: Nth; COG0177 530564008702 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 530564008703 minor groove reading motif; other site 530564008704 helix-hairpin-helix signature motif; other site 530564008705 substrate binding pocket [chemical binding]; other site 530564008706 active site 530564008707 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; cl15304 530564008708 Domain of unknown function (DUF309); Region: DUF309; pfam03745 530564008709 Penicillinase repressor; Region: Pencillinase_R; pfam03965 530564008710 BlaR1 peptidase M56; Region: Peptidase_M56; pfam05569 530564008711 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 530564008712 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 530564008713 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 530564008714 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 530564008715 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 530564008716 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 530564008717 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 530564008718 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 530564008719 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 530564008720 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 530564008721 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 530564008722 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 530564008723 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 530564008724 active site 530564008725 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 530564008726 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 530564008727 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 530564008728 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 530564008729 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 530564008730 cellulose synthase; Region: PLN02400 530564008731 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 530564008732 catalytic residues [active] 530564008733 catalytic nucleophile [active] 530564008734 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 530564008735 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 530564008736 active site 530564008737 catalytic residues [active] 530564008738 DNA binding site [nucleotide binding] 530564008739 Int/Topo IB signature motif; other site 530564008740 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 530564008741 DNA binding site [nucleotide binding] 530564008742 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 530564008743 Sulfatase; Region: Sulfatase; pfam00884 530564008744 HEAT repeats; Region: HEAT_2; pfam13646 530564008745 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 530564008746 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 530564008747 motif II; other site 530564008748 DNA polymerase IV; Validated; Region: PRK01810 530564008749 Y-family of DNA polymerases; Region: PolY; cl12025 530564008750 active site 530564008751 DNA binding site [nucleotide binding] 530564008752 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 530564008753 chaperonin GroL; Region: GroEL; TIGR02348 530564008754 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 530564008755 ring oligomerisation interface [polypeptide binding]; other site 530564008756 ATP/Mg binding site [chemical binding]; other site 530564008757 stacking interactions; other site 530564008758 hinge regions; other site 530564008759 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 530564008760 oligomerisation interface [polypeptide binding]; other site 530564008761 mobile loop; other site 530564008762 roof hairpin; other site 530564008763 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 530564008764 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 530564008765 Protein of unknown function (DUF4013); Region: DUF4013; pfam13197 530564008766 Putative transposase of IS4/5 family (DUF4096); Region: DUF4096; pfam13340 530564008767 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 530564008768 Transposase DDE domain; Region: DDE_Tnp_1_2; pfam13586 530564008769 Protein of unknown function (DUF4013); Region: DUF4013; pfam13197 530564008770 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564008771 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 530564008772 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 530564008773 ssDNA binding site; other site 530564008774 generic binding surface II; other site 530564008775 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 530564008776 ATP binding site [chemical binding]; other site 530564008777 putative Mg++ binding site [ion binding]; other site 530564008778 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 530564008779 nucleotide binding region [chemical binding]; other site 530564008780 ATP-binding site [chemical binding]; other site 530564008781 Protein of unknown function (DUF4254); Region: DUF4254; pfam14063 530564008782 M28 Zn-Peptidases; Region: M28_like_6; cd08656 530564008783 Peptidase family M28; Region: Peptidase_M28; pfam04389 530564008784 metal binding site [ion binding]; metal-binding site 530564008785 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 530564008786 tartrate dehydrogenase; Region: TTC; TIGR02089 530564008787 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 530564008788 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 530564008789 active site 530564008790 DNA binding site [nucleotide binding] 530564008791 hypothetical protein; Provisional; Region: PRK08609 530564008792 Saccharopine dehydrogenase N-terminal domain; Region: SDH_N_domain; cd12144 530564008793 Uncharacterized conserved protein [Function unknown]; Region: COG1915 530564008794 homodimer interface [polypeptide binding]; other site 530564008795 N-Dimethylarginine dimethylaminohydrolase [Amino acid transport and metabolism]; Region: COG1834 530564008796 Amidinotransferase; Region: Amidinotransf; pfam02274 530564008797 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564008798 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564008799 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564008800 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 530564008801 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 530564008802 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 530564008803 DNA binding residues [nucleotide binding] 530564008804 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564008805 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564008806 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564008807 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 530564008808 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 530564008809 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 530564008810 Walker A/P-loop; other site 530564008811 ATP binding site [chemical binding]; other site 530564008812 Q-loop/lid; other site 530564008813 ABC transporter signature motif; other site 530564008814 Walker B; other site 530564008815 D-loop; other site 530564008816 H-loop/switch region; other site 530564008817 Domain of unknown function DUF21; Region: DUF21; pfam01595 530564008818 FOG: CBS domain [General function prediction only]; Region: COG0517 530564008819 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 530564008820 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 530564008821 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4299 530564008822 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 530564008823 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 530564008824 active site 530564008825 (T/H)XGH motif; other site 530564008826 von Willebrand factor (vWF) type A domain; Region: VWA; smart00327 530564008827 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 530564008828 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 530564008829 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 530564008830 catalytic residue [active] 530564008831 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 530564008832 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 530564008833 active site 530564008834 (T/H)XGH motif; other site 530564008835 Predicted acyltransferases [Lipid metabolism]; Region: COG1835 530564008836 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 530564008837 N- and C-terminal domain interface [polypeptide binding]; other site 530564008838 D-xylulose kinase; Region: XylB; TIGR01312 530564008839 active site 530564008840 MgATP binding site [chemical binding]; other site 530564008841 catalytic site [active] 530564008842 metal binding site [ion binding]; metal-binding site 530564008843 xylulose binding site [chemical binding]; other site 530564008844 homodimer interface [polypeptide binding]; other site 530564008845 Isochorismatase family; Region: Isochorismatase; pfam00857 530564008846 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 530564008847 catalytic triad [active] 530564008848 dimer interface [polypeptide binding]; other site 530564008849 conserved cis-peptide bond; other site 530564008850 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564008851 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 530564008852 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 530564008853 Putative catalytic domain, repeat 1, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_1; cd09157 530564008854 putative active site [active] 530564008855 catalytic site [active] 530564008856 Putative catalytic domain, repeat 2, of uncharacterized proteins similar to bacterial cardiolipin synthase; Region: PLDc_CLS_unchar2_2; cd09163 530564008857 putative active site [active] 530564008858 catalytic site [active] 530564008859 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 530564008860 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 530564008861 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 530564008862 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 530564008863 putative catalytic cysteine [active] 530564008864 TPR repeat; Region: TPR_11; pfam13414 530564008865 Periplasmic protease [Cell envelope biogenesis, outer membrane]; Region: Prc; COG0793 530564008866 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 530564008867 protein binding site [polypeptide binding]; other site 530564008868 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 530564008869 Catalytic dyad [active] 530564008870 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 530564008871 Mn2+ and Fe2+ transporters of the NRAMP family [Inorganic ion transport and metabolism]; Region: MntH; cl15845 530564008872 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4586 530564008873 ATP-binding cassette domain of an uncharacterized transporter similar in sequence to NatA; Region: ABC_NatA_like; cd03267 530564008874 Walker A/P-loop; other site 530564008875 ATP binding site [chemical binding]; other site 530564008876 Q-loop/lid; other site 530564008877 ABC transporter signature motif; other site 530564008878 Walker B; other site 530564008879 D-loop; other site 530564008880 H-loop/switch region; other site 530564008881 zinc metallopeptidase RseP; Provisional; Region: PRK10779 530564008882 transcription termination factor Rho; Provisional; Region: rho; PRK09376 530564008883 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 530564008884 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 530564008885 RNA binding site [nucleotide binding]; other site 530564008886 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 530564008887 multimer interface [polypeptide binding]; other site 530564008888 Walker A motif; other site 530564008889 ATP binding site [chemical binding]; other site 530564008890 Walker B motif; other site 530564008891 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 530564008892 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 530564008893 CoA-binding site [chemical binding]; other site 530564008894 ATP-binding [chemical binding]; other site 530564008895 DNA polymerase I; Provisional; Region: PRK05755 530564008896 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 530564008897 active site 530564008898 metal binding site 1 [ion binding]; metal-binding site 530564008899 putative 5' ssDNA interaction site; other site 530564008900 metal binding site 3; metal-binding site 530564008901 metal binding site 2 [ion binding]; metal-binding site 530564008902 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 530564008903 putative DNA binding site [nucleotide binding]; other site 530564008904 putative metal binding site [ion binding]; other site 530564008905 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 530564008906 active site 530564008907 catalytic site [active] 530564008908 substrate binding site [chemical binding]; other site 530564008909 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 530564008910 active site 530564008911 DNA binding site [nucleotide binding] 530564008912 catalytic site [active] 530564008913 HEAT repeats; Region: HEAT_2; pfam13646 530564008914 HEAT repeats; Region: HEAT_2; pfam13646 530564008915 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 530564008916 active site 530564008917 TatD related DNase; Region: TatD_DNase; pfam01026 530564008918 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 530564008919 PDZ domain; Region: PDZ_2; pfam13180 530564008920 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 530564008921 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 530564008922 substrate binding site [chemical binding]; other site 530564008923 ATP binding site [chemical binding]; other site 530564008924 2'-5' RNA ligase; Region: 2_5_ligase; TIGR02258 530564008925 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 530564008926 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 530564008927 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 530564008928 recombinase A; Provisional; Region: recA; PRK09354 530564008929 hexamer interface [polypeptide binding]; other site 530564008930 Walker A motif; other site 530564008931 ATP binding site [chemical binding]; other site 530564008932 Walker B motif; other site 530564008933 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 530564008934 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 530564008935 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 530564008936 protein binding site [polypeptide binding]; other site 530564008937 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 530564008938 Methyltransferase domain; Region: Methyltransf_31; pfam13847 530564008939 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 530564008940 S-adenosylmethionine binding site [chemical binding]; other site 530564008941 Uncharacterized conserved protein [Function unknown]; Region: COG1359 530564008942 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 530564008943 XdhC Rossmann domain; Region: XdhC_C; pfam13478 530564008944 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 530564008945 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 530564008946 Ligand binding site; other site 530564008947 metal-binding site 530564008948 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 530564008949 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 530564008950 Walker A/P-loop; other site 530564008951 ATP binding site [chemical binding]; other site 530564008952 Q-loop/lid; other site 530564008953 ABC transporter signature motif; other site 530564008954 Walker B; other site 530564008955 D-loop; other site 530564008956 H-loop/switch region; other site 530564008957 Domain of unknown function (DUF4162); Region: DUF4162; pfam13732 530564008958 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 530564008959 active site 530564008960 Zn binding site [ion binding]; other site 530564008961 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 530564008962 active site 530564008963 Zn binding site [ion binding]; other site 530564008964 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 530564008965 Thermotoga maritima CorA_like subfamily; Region: TmCorA-like_1; cd12828 530564008966 oligomer interface [polypeptide binding]; other site 530564008967 metal binding site [ion binding]; metal-binding site 530564008968 metal binding site [ion binding]; metal-binding site 530564008969 Cl binding site [ion binding]; other site 530564008970 aspartate ring; other site 530564008971 basic sphincter; other site 530564008972 putative hydrophobic gate; other site 530564008973 periplasmic entrance; other site 530564008974 Mechanosensitive ion channel; Region: MS_channel; pfam00924 530564008975 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 530564008976 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 530564008977 substrate binding site [chemical binding]; other site 530564008978 active site 530564008979 catalytic residues [active] 530564008980 heterodimer interface [polypeptide binding]; other site 530564008981 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 530564008982 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 530564008983 pyridoxal 5'-phosphate binding site [chemical binding]; other site 530564008984 catalytic residue [active] 530564008985 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 530564008986 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 530564008987 DNA binding site [nucleotide binding] 530564008988 catalytic residue [active] 530564008989 H2TH interface [polypeptide binding]; other site 530564008990 putative catalytic residues [active] 530564008991 turnover-facilitating residue; other site 530564008992 intercalation triad [nucleotide binding]; other site 530564008993 8OG recognition residue [nucleotide binding]; other site 530564008994 putative reading head residues; other site 530564008995 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 530564008996 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 530564008997 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 530564008998 Mechanosensitive ion channel; Region: MS_channel; pfam00924 530564008999 Protein of unknown function (DUF3500); Region: DUF3500; pfam12006 530564009000 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; COG0405 530564009001 Gamma-glutamyltranspeptidase; Region: G_glu_transpept; pfam01019 530564009002 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 530564009003 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 530564009004 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 530564009005 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 530564009006 Trp docking motif [polypeptide binding]; other site 530564009007 active site 530564009008 PQQ-like domain; Region: PQQ_2; pfam13360 530564009009 Protein of unknown function (DUF2185); Region: DUF2185; cl02019 530564009010 Alanyl-tRNA synthetase [Translation, ribosomal structure and biogenesis]; Region: AlaS; COG0013 530564009011 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 530564009012 motif 1; other site 530564009013 active site 530564009014 motif 2; other site 530564009015 motif 3; other site 530564009016 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 530564009017 DHHA1 domain; Region: DHHA1; pfam02272 530564009018 acyl-CoA synthetase; Validated; Region: PRK05850 530564009019 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 530564009020 acyl-activating enzyme (AAE) consensus motif; other site 530564009021 active site 530564009022 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 530564009023 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 530564009024 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 530564009025 substrate-cofactor binding pocket; other site 530564009026 pyridoxal 5'-phosphate binding site [chemical binding]; other site 530564009027 catalytic residue [active] 530564009028 Methyltransferase domain; Region: Methyltransf_31; pfam13847 530564009029 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 530564009030 S-adenosylmethionine binding site [chemical binding]; other site 530564009031 Methyltransferase domain; Region: Methyltransf_31; pfam13847 530564009032 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 530564009033 S-adenosylmethionine binding site [chemical binding]; other site 530564009034 methyltransferase, FkbM family; Region: fkbM_fam; TIGR01444 530564009035 anthranilate synthase component I, non-proteobacterial lineages; Region: trpE_most; TIGR00564 530564009036 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 530564009037 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 530564009038 Modulator of heat shock repressor CtsR, McsA [Signal transduction mechanisms]; Region: COG3880 530564009039 UvrB/uvrC motif; Region: UVR; pfam02151 530564009040 ATP:guanido phosphotransferase; Provisional; Region: PRK01059 530564009041 Phosphagen (guanidino) kinases found in bacteria; Region: bacterial_phosphagen_kinase; cd07930 530564009042 ADP binding site [chemical binding]; other site 530564009043 phosphagen binding site; other site 530564009044 substrate specificity loop; other site 530564009045 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 530564009046 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 530564009047 Coenzyme A binding pocket [chemical binding]; other site 530564009048 Response regulator [Signal transduction mechanisms]; Region: TtrR; COG4566 530564009049 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564009050 active site 530564009051 phosphorylation site [posttranslational modification] 530564009052 intermolecular recognition site; other site 530564009053 dimerization interface [polypeptide binding]; other site 530564009054 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 530564009055 DNA binding residues [nucleotide binding] 530564009056 dimerization interface [polypeptide binding]; other site 530564009057 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 530564009058 EpsO protein participates in the methanolan synthesis; Region: EpsO_like; cd06438 530564009059 DXD motif; other site 530564009060 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 530564009061 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 530564009062 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 530564009063 Protein involved in cellulose biosynthesis (CelD) [Cell envelope biogenesis, outer membrane]; Region: COG5653 530564009064 Acetyltransferase (GNAT) domain; Region: Acetyltransf_6; pfam13480 530564009065 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 530564009066 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 530564009067 active site 530564009068 O-Antigen ligase; Region: Wzy_C; pfam04932 530564009069 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 530564009070 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 530564009071 Putative catalytic NodB homology domain of PgaB, IcaB, and similar proteins which consist of a deformed (beta/alpha)8 barrel fold with 5- or 6-strands; Region: CE4_NodB_like_5s_6s; cd10918 530564009072 putative active site [active] 530564009073 putative metal binding site [ion binding]; other site 530564009074 polysaccharide chain length determinant protein, PEP-CTERM locus subfamily; Region: pepcterm_ChnLen; TIGR03007 530564009075 Chain length determinant protein; Region: Wzz; cl15801 530564009076 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 530564009077 argininosuccinate synthase; Provisional; Region: PRK13820 530564009078 ANP binding site [chemical binding]; other site 530564009079 Substrate Binding Site II [chemical binding]; other site 530564009080 Substrate Binding Site I [chemical binding]; other site 530564009081 NCAIR mutase (PurE)-related proteins [General function prediction only]; Region: COG1691 530564009082 AIR carboxylase; Region: AIRC; smart01001 530564009083 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 530564009084 putative substrate binding site [chemical binding]; other site 530564009085 putative ATP binding site [chemical binding]; other site 530564009086 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 530564009087 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 530564009088 active site 530564009089 Riboflavin kinase; Region: Flavokinase; pfam01687 530564009090 Exopolyphosphatase-related proteins [General function prediction only]; Region: COG0618 530564009091 DHH family; Region: DHH; pfam01368 530564009092 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cd03467 530564009093 iron-sulfur cluster [ion binding]; other site 530564009094 [2Fe-2S] cluster binding site [ion binding]; other site 530564009095 Cytochrome b subunit of the bc complex [Energy production and conversion]; Region: QcrB; COG1290 530564009096 intrachain domain interface; other site 530564009097 interchain domain interface [polypeptide binding]; other site 530564009098 Cytochrome b (N-terminus)/b6/petB: Cytochrome b is a subunit of cytochrome bc1, an 11-subunit mitochondrial respiratory enzyme. Cytochrome b spans the mitochondrial membrane with 8 transmembrane helices (A-H) in eukaryotes. In plants and cyanobacteria; Region: Cytochrome_b_N; cl00859 530564009099 heme bH binding site [chemical binding]; other site 530564009100 Qi binding site; other site 530564009101 heme bL binding site [chemical binding]; other site 530564009102 Qo binding site; other site 530564009103 Cytochrome c; Region: Cytochrom_C; pfam00034 530564009104 Cytochrome c; Region: Cytochrom_C; pfam00034 530564009105 TPR repeat; Region: TPR_11; pfam13414 530564009106 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564009107 binding surface 530564009108 TPR motif; other site 530564009109 type II secretion system protein D; Region: type_II_gspD; TIGR02517 530564009110 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 530564009111 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 530564009112 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 530564009113 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 530564009114 Zn binding site [ion binding]; other site 530564009115 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 530564009116 conserved cys residue [active] 530564009117 NAD-dependent deacetylase; Provisional; Region: PRK00481 530564009118 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 530564009119 NAD+ binding site [chemical binding]; other site 530564009120 substrate binding site [chemical binding]; other site 530564009121 Zn binding site [ion binding]; other site 530564009122 PQQ-like domain; Region: PQQ_2; pfam13360 530564009123 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564009124 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564009125 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564009126 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 530564009127 FOG: WD40 repeat [General function prediction only]; Region: COG2319 530564009128 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cd00200 530564009129 structural tetrad; other site 530564009130 Trehalose utilisation; Region: ThuA; pfam06283 530564009131 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 530564009132 active site 530564009133 catalytic residues [active] 530564009134 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 530564009135 Capsular polysaccharide biosynthesis protein [Carbohydrate transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: CapC; COG4464 530564009136 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 530564009137 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 530564009138 dimer interface [polypeptide binding]; other site 530564009139 active site 530564009140 CoA binding pocket [chemical binding]; other site 530564009141 Uncharacterized ACR, COG1678; Region: DUF179; pfam02622 530564009142 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 530564009143 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 530564009144 dimer interface [polypeptide binding]; other site 530564009145 phosphorylation site [posttranslational modification] 530564009146 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 530564009147 ATP binding site [chemical binding]; other site 530564009148 Mg2+ binding site [ion binding]; other site 530564009149 G-X-G motif; other site 530564009150 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 530564009151 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564009152 active site 530564009153 phosphorylation site [posttranslational modification] 530564009154 intermolecular recognition site; other site 530564009155 dimerization interface [polypeptide binding]; other site 530564009156 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 530564009157 DNA binding site [nucleotide binding] 530564009158 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 530564009159 metal ion-dependent adhesion site (MIDAS); other site 530564009160 Glycosylasparaginase catalyzes the hydrolysis of the glycosylamide bond of asparagine-linked glycoproteins. This enzyme is an amidase located inside lysosomes. Mutation of this gene in humans causes a genetic disorder known as aspartylglycosaminuria (AGU)...; Region: Glycosylasparaginase; cd04513 530564009161 active site 530564009162 dimer interface [polypeptide binding]; other site 530564009163 catalytic nucleophile [active] 530564009164 Type I phosphodiesterase / nucleotide pyrophosphatase; Region: Phosphodiest; pfam01663 530564009165 Uncharacterized conserved protein [Function unknown]; Region: COG3379 530564009166 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 530564009167 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 530564009168 DNA interaction; other site 530564009169 Metal-binding active site; metal-binding site 530564009170 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 530564009171 UbiA prenyltransferase family; Region: UbiA; pfam01040 530564009172 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 530564009173 Fatty acid desaturase; Region: FA_desaturase; pfam00487 530564009174 Di-iron ligands [ion binding]; other site 530564009175 The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide...; Region: Delta9-FADS-like; cd03505 530564009176 RNA-binding proteins (RRM domain) [General function prediction only]; Region: COG0724 530564009177 RNA recognition motif in Helicobacter pylori HP0827 protein and similar proteins; Region: RRM_HP0827_like; cd12399 530564009178 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564009179 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 530564009180 putative membrane-bound dehydrogenase domain; Region: Piru_Ver_Nterm; TIGR02604 530564009181 Cytochrome c; Region: Cytochrom_C; pfam00034 530564009182 domain in bacterial beta-glucosidases other glycosidases, glycosyltransferases, proteases, amidases, yeast adhesins, and bacterial toxins; Region: PA14; smart00758 530564009183 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 530564009184 ABC-2 family transporter protein; Region: ABC2_membrane_6; cl01496 530564009185 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564009186 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 530564009187 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 530564009188 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 530564009189 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 530564009190 Cupin domain; Region: Cupin_2; pfam07883 530564009191 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 530564009192 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 530564009193 active site 530564009194 ATP binding site [chemical binding]; other site 530564009195 substrate binding site [chemical binding]; other site 530564009196 activation loop (A-loop); other site 530564009197 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 530564009198 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 530564009199 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 530564009200 RNA binding surface [nucleotide binding]; other site 530564009201 Pyruvate/2-oxoglutarate dehydrogenase complex, dihydrolipoamide dehydrogenase (E3) component, and related enzymes [Energy production and conversion]; Region: Lpd; COG1249 530564009202 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 530564009203 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 530564009204 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 530564009205 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 530564009206 dimer interface [polypeptide binding]; other site 530564009207 TPP-binding site [chemical binding]; other site 530564009208 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 530564009209 E3 interaction surface; other site 530564009210 lipoyl attachment site [posttranslational modification]; other site 530564009211 dihydrolipoamide acetyltransferase; Reviewed; Region: PRK11857 530564009212 e3 binding domain; Region: E3_binding; pfam02817 530564009213 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 530564009214 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 530564009215 The S24, S26 LexA/signal peptidase superfamily contains LexA-related and type I signal peptidase families. The S24 LexA protein domains include: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC 3.4.21.88), the...; Region: Peptidase_S24_S26; cl10465 530564009216 DinB family; Region: DinB; cl17821 530564009217 DinB superfamily; Region: DinB_2; pfam12867 530564009218 Uncharacterized virulence-associated protein D [Function unknown]; Region: VapD; COG3309 530564009219 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK02862 530564009220 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 530564009221 ligand binding site; other site 530564009222 oligomer interface; other site 530564009223 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 530564009224 dimer interface [polypeptide binding]; other site 530564009225 N-terminal domain interface [polypeptide binding]; other site 530564009226 sulfate 1 binding site; other site 530564009227 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 530564009228 S-adenosylmethionine binding site [chemical binding]; other site 530564009229 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 530564009230 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 530564009231 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 530564009232 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Region: murF; TIGR01143 530564009233 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 530564009234 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 530564009235 NAD(P) binding site [chemical binding]; other site 530564009236 active site 530564009237 periplasmic serine protease, Do/DeqQ family; Region: degP_htrA_DO; TIGR02037 530564009238 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 530564009239 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 530564009240 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 530564009241 protein binding site [polypeptide binding]; other site 530564009242 thiamine monophosphate kinase; Provisional; Region: PRK05731 530564009243 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 530564009244 ATP binding site [chemical binding]; other site 530564009245 dimerization interface [polypeptide binding]; other site 530564009246 Predicted ATPase or kinase [General function prediction only]; Region: COG0802 530564009247 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 530564009248 active site 530564009249 Mannose-1-phosphate guanylyltransferase [Cell envelope biogenesis, outer membrane]; Region: {ManC}; COG0836 530564009250 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 530564009251 Substrate binding site; other site 530564009252 Cupin domain; Region: Cupin_2; cl17218 530564009253 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 530564009254 Putative serine esterase (DUF676); Region: DUF676; pfam05057 530564009255 Uncharacterized protein family (UPF0081); Region: UPF0081; pfam03652 530564009256 Domain of unknown function (DUF4404); Region: DUF4404; pfam14357 530564009257 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 530564009258 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 530564009259 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 530564009260 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 530564009261 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 530564009262 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 530564009263 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 530564009264 putative NAD(P) binding site [chemical binding]; other site 530564009265 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 530564009266 FecR protein; Region: FecR; pfam04773 530564009267 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 530564009268 RNA polymerase sigma-70 factor, Rhodopirellula/Verrucomicrobium family; Region: Sig-70_gvs1; TIGR02989 530564009269 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 530564009270 Sigma-70, region 4; Region: Sigma70_r4_2; pfam08281 530564009271 DNA binding residues [nucleotide binding] 530564009272 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 530564009273 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 530564009274 dimer interface [polypeptide binding]; other site 530564009275 decamer (pentamer of dimers) interface [polypeptide binding]; other site 530564009276 catalytic triad [active] 530564009277 peroxidatic and resolving cysteines [active] 530564009278 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 530564009279 Zn2+ binding site [ion binding]; other site 530564009280 Mg2+ binding site [ion binding]; other site 530564009281 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 530564009282 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 530564009283 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 530564009284 Amidase; Region: Amidase; cl11426 530564009285 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 530564009286 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 530564009287 trimer interface [polypeptide binding]; other site 530564009288 putative metal binding site [ion binding]; other site 530564009289 biotin synthase; Validated; Region: PRK06256 530564009290 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 530564009291 FeS/SAM binding site; other site 530564009292 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 530564009293 di-heme enzyme, MXAN_0977 family; Region: MXAN_0977_Heme2; TIGR04039 530564009294 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 530564009295 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 530564009296 substrate binding site [chemical binding]; other site 530564009297 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 530564009298 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 530564009299 substrate binding site [chemical binding]; other site 530564009300 ligand binding site [chemical binding]; other site 530564009301 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 530564009302 Catalytic domain of Protein Kinases; Region: PKc; cd00180 530564009303 active site 530564009304 ATP binding site [chemical binding]; other site 530564009305 substrate binding site [chemical binding]; other site 530564009306 activation loop (A-loop); other site 530564009307 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 530564009308 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564009309 active site 530564009310 phosphorylation site [posttranslational modification] 530564009311 intermolecular recognition site; other site 530564009312 dimerization interface [polypeptide binding]; other site 530564009313 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 530564009314 DNA binding residues [nucleotide binding] 530564009315 dimerization interface [polypeptide binding]; other site 530564009316 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 530564009317 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 530564009318 metal binding site [ion binding]; metal-binding site 530564009319 substrate binding pocket [chemical binding]; other site 530564009320 Etoposide-induced protein 2.4 (EI24); Region: EI24; cl01126 530564009321 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 530564009322 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 530564009323 catalytic residue [active] 530564009324 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 530564009325 Global regulator protein family; Region: CsrA; pfam02599 530564009326 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564009327 binding surface 530564009328 TPR motif; other site 530564009329 lipoprotein NlpI; Provisional; Region: PRK11189 530564009330 Pyridoxine 5'-phosphate (PNP) oxidase-like proteins; Region: PNPOx_like; cl00381 530564009331 TPR repeat; Region: TPR_11; pfam13414 530564009332 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564009333 binding surface 530564009334 TPR motif; other site 530564009335 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 530564009336 Sulfatase; Region: Sulfatase; cl17466 530564009337 choline-sulfatase; Region: chol_sulfatase; TIGR03417 530564009338 Sulfatase; Region: Sulfatase; cl17466 530564009339 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 530564009340 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 530564009341 Sulfatase; Region: Sulfatase; cl17466 530564009342 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 530564009343 active site 530564009344 metal binding site [ion binding]; metal-binding site 530564009345 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 530564009346 Sulfatase; Region: Sulfatase; pfam00884 530564009347 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 530564009348 Sulfatase; Region: Sulfatase; pfam00884 530564009349 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 530564009350 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 530564009351 Peptidase Gluzincin family (thermolysin-like proteinases, TLPs) includes peptidases M1, M2, M3, M4, M13, M32 and M36 (fungalysins); Region: GluZincin; cl14813 530564009352 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 530564009353 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 530564009354 ATP-NAD kinase; Region: NAD_kinase; pfam01513 530564009355 NAD kinase [Coenzyme metabolism]; Region: nadF; COG0061 530564009356 1-deoxy-D-xylulose-5-phosphate synthase; Provisional; Region: PRK05444 530564009357 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 530564009358 TPP-binding site; other site 530564009359 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 530564009360 PYR/PP interface [polypeptide binding]; other site 530564009361 dimer interface [polypeptide binding]; other site 530564009362 TPP binding site [chemical binding]; other site 530564009363 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 530564009364 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 530564009365 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 530564009366 substrate binding pocket [chemical binding]; other site 530564009367 chain length determination region; other site 530564009368 substrate-Mg2+ binding site; other site 530564009369 catalytic residues [active] 530564009370 aspartate-rich region 1; other site 530564009371 active site lid residues [active] 530564009372 aspartate-rich region 2; other site 530564009373 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 530564009374 exodeoxyribonuclease VII large subunit; Reviewed; Region: xseA; PRK00286 530564009375 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 530564009376 generic binding surface I; other site 530564009377 generic binding surface II; other site 530564009378 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 530564009379 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 530564009380 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 530564009381 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 530564009382 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 530564009383 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 530564009384 Dolichyl-phosphate-mannose-protein mannosyltransferase; Region: PMT_2; pfam13231 530564009385 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 530564009386 Major Facilitator Superfamily; Region: MFS_1; pfam07690 530564009387 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 530564009388 tRNA(Ile)-lysidine synthase MesJ [Cell cycle control, cell division, chromosome partitioning]; Region: MesJ; COG0037 530564009389 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 530564009390 ribonuclease Y; Region: RNase_Y; TIGR03319 530564009391 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 530564009392 Zn2+ binding site [ion binding]; other site 530564009393 Mg2+ binding site [ion binding]; other site 530564009394 Deinococcus radiodurans DR1281 and related proteins, metallophosphatase domain; Region: MPP_DR1281; cd07382 530564009395 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 530564009396 putative active site [active] 530564009397 metal binding site [ion binding]; metal-binding site 530564009398 homodimer binding site [polypeptide binding]; other site 530564009399 Protein of unknown function (DUF2752); Region: DUF2752; pfam10825 530564009400 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 530564009401 metal ion-dependent adhesion site (MIDAS); other site 530564009402 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 530564009403 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 530564009404 Preprotein translocase subunit SecD [Intracellular trafficking and secretion]; Region: SecD; COG0342 530564009405 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 530564009406 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 530564009407 Protein export membrane protein; Region: SecD_SecF; pfam02355 530564009408 Preprotein translocase subunit; Region: YajC; pfam02699 530564009409 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 530564009410 Queuine/archaeosine tRNA-ribosyltransferase [Translation, ribosomal structure and biogenesis]; Region: Tgt; COG0343 530564009411 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564009412 binding surface 530564009413 TPR motif; other site 530564009414 TPR repeat; Region: TPR_11; pfam13414 530564009415 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 530564009416 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 530564009417 Sphingosine kinase and enzymes related to eukaryotic diacylglycerol kinase [Lipid metabolism / General function prediction only]; Region: LCB5; COG1597 530564009418 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 530564009419 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 530564009420 Anaphase-promoting complex, cyclosome, subunit 3; Region: Apc3; pfam12895 530564009421 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 530564009422 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 530564009423 active site 530564009424 MoxR-like ATPases [General function prediction only]; Region: COG0714 530564009425 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 530564009426 Walker B motif; other site 530564009427 arginine finger; other site 530564009428 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 530564009429 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 530564009430 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 530564009431 Protein of unknown function DUF58; Region: DUF58; pfam01882 530564009432 Predicted esterase [General function prediction only]; Region: COG0400 530564009433 Cutinase; Region: Cutinase; pfam01083 530564009434 Ferritin-like domain; Region: Ferritin; pfam00210 530564009435 Ferritin-like superfamily of diiron-containing four-helix-bundle proteins; Region: Ferritin_like; cd00657 530564009436 dinuclear metal binding motif [ion binding]; other site 530564009437 Rrf2 family protein; Region: rrf2_super; TIGR00738 530564009438 Transcriptional regulator; Region: Rrf2; pfam02082 530564009439 Predominantly bacterial family of Mg++ dependend phosphatases, related to inositol monophosphatases. These enzymes may dephosphorylate fructose-1,6-bisphosphate, inositol monophospate, 3'-phosphoadenosine-5'-phosphate, or similar substrates; Region: Bacterial_IMPase_like_1; cd01641 530564009440 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 530564009441 active site 530564009442 TlpA-like family; composed of TlpA, ResA, DsbE and similar proteins. TlpA, ResA and DsbE are bacterial protein disulfide reductases with important roles in cytochrome maturation. They are membrane-anchored proteins with a soluble TRX domain containing a...; Region: TlpA_like_family; cd02966 530564009443 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 530564009444 catalytic residues [active] 530564009445 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 530564009446 16S/18S rRNA binding site [nucleotide binding]; other site 530564009447 S13e-L30e interaction site [polypeptide binding]; other site 530564009448 25S rRNA binding site [nucleotide binding]; other site 530564009449 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 530564009450 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 530564009451 RNase E interface [polypeptide binding]; other site 530564009452 trimer interface [polypeptide binding]; other site 530564009453 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 530564009454 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 530564009455 RNase E interface [polypeptide binding]; other site 530564009456 trimer interface [polypeptide binding]; other site 530564009457 active site 530564009458 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 530564009459 putative nucleic acid binding region [nucleotide binding]; other site 530564009460 G-X-X-G motif; other site 530564009461 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 530564009462 RNA binding site [nucleotide binding]; other site 530564009463 domain interface; other site 530564009464 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 530564009465 dimer interface [polypeptide binding]; other site 530564009466 phosphorylation site [posttranslational modification] 530564009467 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 530564009468 ATP binding site [chemical binding]; other site 530564009469 Mg2+ binding site [ion binding]; other site 530564009470 G-X-G motif; other site 530564009471 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 530564009472 metal binding site 2 [ion binding]; metal-binding site 530564009473 putative DNA binding helix; other site 530564009474 metal binding site 1 [ion binding]; metal-binding site 530564009475 dimer interface [polypeptide binding]; other site 530564009476 structural Zn2+ binding site [ion binding]; other site 530564009477 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 530564009478 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 530564009479 Ca2+ binding site [ion binding]; other site 530564009480 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 530564009481 Ca2+ binding site [ion binding]; other site 530564009482 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cl17302 530564009483 EF-hand domain pair; Region: EF_hand_5; pfam13499 530564009484 pseudo EF-hand loop; other site 530564009485 peptide binding pocket; other site 530564009486 Ca2+ binding site [ion binding]; other site 530564009487 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 530564009488 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 530564009489 phosphopeptide binding site; other site 530564009490 GAF domain; Region: GAF; pfam01590 530564009491 Stage II sporulation protein E (SpoIIE); Region: SpoIIE; pfam07228 530564009492 heavy metal translocating P-type ATPase; Region: ATPase-IB_hvy; TIGR01525 530564009493 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 530564009494 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 530564009495 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 530564009496 Zn2+ binding site [ion binding]; other site 530564009497 Mg2+ binding site [ion binding]; other site 530564009498 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 530564009499 PAS domain; Region: PAS_9; pfam13426 530564009500 putative active site [active] 530564009501 heme pocket [chemical binding]; other site 530564009502 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 530564009503 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 530564009504 metal binding site [ion binding]; metal-binding site 530564009505 active site 530564009506 I-site; other site 530564009507 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 530564009508 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 530564009509 shikimate kinase; Reviewed; Region: aroK; PRK00131 530564009510 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 530564009511 ADP binding site [chemical binding]; other site 530564009512 magnesium binding site [ion binding]; other site 530564009513 putative shikimate binding site; other site 530564009514 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 530564009515 bifunctional 3-dehydroquinate dehydratase/shikimate dehydrogenase; Region: PLN02520 530564009516 active site 530564009517 catalytic residue [active] 530564009518 dimer interface [polypeptide binding]; other site 530564009519 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 530564009520 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 530564009521 shikimate binding site; other site 530564009522 NAD(P) binding site [chemical binding]; other site 530564009523 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 530564009524 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564009525 active site 530564009526 phosphorylation site [posttranslational modification] 530564009527 intermolecular recognition site; other site 530564009528 dimerization interface [polypeptide binding]; other site 530564009529 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564009530 Walker A motif; other site 530564009531 ATP binding site [chemical binding]; other site 530564009532 Walker B motif; other site 530564009533 arginine finger; other site 530564009534 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 530564009535 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 530564009536 ABC-type Na+ efflux pump, permease component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatB; COG1668 530564009537 Protein kinase domain; Region: Pkinase; pfam00069 530564009538 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 530564009539 active site 530564009540 ATP binding site [chemical binding]; other site 530564009541 substrate binding site [chemical binding]; other site 530564009542 activation loop (A-loop); other site 530564009543 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 530564009544 active site clefts [active] 530564009545 zinc binding site [ion binding]; other site 530564009546 dimer interface [polypeptide binding]; other site 530564009547 glutamate dehydrogenase; Region: PLN02477 530564009548 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 530564009549 NAD(P) binding domain of glutamate dehydrogenase, subgroup 1; Region: NAD_bind_1_Glu_DH; cd01076 530564009550 NAD(P) binding site [chemical binding]; other site 530564009551 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 530564009552 putative active site [active] 530564009553 NIPSNAP; Region: NIPSNAP; pfam07978 530564009554 Adenylosuccinate lyase [Nucleotide transport and metabolism]; Region: PurB; COG0015 530564009555 Adenylsuccinate lyase (ASL)_subgroup 2; Region: Adenylsuccinate_lyase_2; cd03302 530564009556 tetramer interface [polypeptide binding]; other site 530564009557 active site 530564009558 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; pfam01887 530564009559 S-adenosyl-l-methionine hydroxide adenosyltransferase; Region: SAM_adeno_trans; cl17774 530564009560 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 530564009561 adenosylmethionine-8-amino-7-oxononanoate transaminase; Region: bioA; TIGR00508 530564009562 inhibitor-cofactor binding pocket; inhibition site 530564009563 pyridoxal 5'-phosphate binding site [chemical binding]; other site 530564009564 catalytic residue [active] 530564009565 Troponin; Region: Troponin; pfam00992 530564009566 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 530564009567 16S RNA G1207 methylase RsmC [Translation, ribosomal structure and biogenesis]; Region: RsmC; COG2813 530564009568 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 530564009569 SNF2 family N-terminal domain; Region: SNF2_N; pfam00176 530564009570 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 530564009571 ATP binding site [chemical binding]; other site 530564009572 putative Mg++ binding site [ion binding]; other site 530564009573 Superfamily II DNA and RNA helicases [DNA replication, recombination, and repair / Transcription / Translation, ribosomal structure and biogenesis]; Region: SrmB; COG0513 530564009574 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 530564009575 nucleotide binding region [chemical binding]; other site 530564009576 ATP-binding site [chemical binding]; other site 530564009577 Herpesvirus UL6 like; Region: Herpes_UL6; pfam01763 530564009578 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 530564009579 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 530564009580 active site 530564009581 ATP binding site [chemical binding]; other site 530564009582 substrate binding site [chemical binding]; other site 530564009583 activation loop (A-loop); other site 530564009584 RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984 530564009585 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 530564009586 DNA binding residues [nucleotide binding] 530564009587 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 530564009588 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 530564009589 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 530564009590 DNA binding residues [nucleotide binding] 530564009591 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564009592 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 530564009593 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564009594 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 530564009595 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564009596 Domain of unknown function (DUF1802); Region: DUF1802; cl01755 530564009597 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 530564009598 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 530564009599 Transposase IS200 like; Region: Y1_Tnp; cl00848 530564009600 3-deoxy-7-phosphoheptulonate synthase; Reviewed; Region: PRK08673 530564009601 3-deoxy-D-manno-octulosonic acid (KDO) 8-phosphate synthase [Cell envelope biogenesis, outer membrane]; Region: KdsA; cl17225 530564009602 ATPase components of ABC transporters with duplicated ATPase domains [General function prediction only]; Region: Uup; COG0488 530564009603 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 530564009604 Walker A/P-loop; other site 530564009605 ATP binding site [chemical binding]; other site 530564009606 Q-loop/lid; other site 530564009607 ABC transporter signature motif; other site 530564009608 Walker B; other site 530564009609 D-loop; other site 530564009610 H-loop/switch region; other site 530564009611 ABC transporter; Region: ABC_tran_2; pfam12848 530564009612 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 530564009613 MiaE tRNA-modifying nonheme diiron monooxygenase, ferritin-like diiron-binding domain; Region: MiaE; cd07910 530564009614 active site 530564009615 dinuclear metal binding site [ion binding]; other site 530564009616 dimerization interface [polypeptide binding]; other site 530564009617 zinc-ribbon domain; Region: zf-ribbon_3; pfam13248 530564009618 TM2 domain; Region: TM2; cl00984 530564009619 TM2 domain; Region: TM2; cl00984 530564009620 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 530564009621 MORN repeat variant; Region: MORN_2; pfam07661 530564009622 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2849 530564009623 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 530564009624 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564009625 active site 530564009626 phosphorylation site [posttranslational modification] 530564009627 intermolecular recognition site; other site 530564009628 dimerization interface [polypeptide binding]; other site 530564009629 CheB methylesterase; Region: CheB_methylest; pfam01339 530564009630 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 530564009631 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 530564009632 FeS/SAM binding site; other site 530564009633 Radical SAM superfamily; Region: Radical_SAM; pfam04055 530564009634 Calcineurin-like phosphoesterase superfamily domain; Region: Metallophos_2; pfam12850 530564009635 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 530564009636 active site 530564009637 metal binding site [ion binding]; metal-binding site 530564009638 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 530564009639 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 530564009640 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 530564009641 DNA binding residues [nucleotide binding] 530564009642 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 530564009643 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 530564009644 SnoaL-like domain; Region: SnoaL_2; pfam12680 530564009645 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 530564009646 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 530564009647 NAD(P) binding site [chemical binding]; other site 530564009648 Na+/H+ antiporter 1; Region: Na_H_antiport_1; cl01133 530564009649 PRC-barrel domain; Region: PRC; pfam05239 530564009650 Prokaryotic lipoprotein-attachment site; Region: LPAM_2; cl02361 530564009651 VCBS repeat; Region: VCBS_repeat; TIGR01965 530564009652 VCBS repeat; Region: VCBS_repeat; TIGR01965 530564009653 Protein of unknown function (DUF1551); Region: DUF1551; pfam07585 530564009654 sulfite reductase; Provisional; Region: PRK06214 530564009655 Putative Fe-S cluster; Region: FeS; cl17515 530564009656 Ferredoxin reductase (FNR), an FAD and NAD(P) binding protein, was intially identified as a chloroplast reductase activity, catalyzing the electron transfer from reduced iron-sulfur protein ferredoxin to NADP+ as the final step in the electron transport...; Region: FNR_like; cl06868 530564009657 FAD binding pocket [chemical binding]; other site 530564009658 conserved FAD binding motif [chemical binding]; other site 530564009659 phosphate binding motif [ion binding]; other site 530564009660 beta-alpha-beta structure motif; other site 530564009661 NAD binding pocket [chemical binding]; other site 530564009662 ferredoxin-nitrite reductase; Reviewed; Region: nirA; PRK09567 530564009663 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 530564009664 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 530564009665 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 530564009666 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 530564009667 [4Fe-4S] binding site [ion binding]; other site 530564009668 molybdopterin cofactor binding site; other site 530564009669 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 530564009670 molybdopterin cofactor binding site; other site 530564009671 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 530564009672 DMSO reductase anchor subunit (DmsC); Region: DmsC; cl17519 530564009673 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 530564009674 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 530564009675 Walker A/P-loop; other site 530564009676 ATP binding site [chemical binding]; other site 530564009677 Q-loop/lid; other site 530564009678 ABC transporter signature motif; other site 530564009679 Walker B; other site 530564009680 D-loop; other site 530564009681 H-loop/switch region; other site 530564009682 ABC-type nitrate/sulfonate/bicarbonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: TauB; COG1116 530564009683 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 530564009684 Walker A/P-loop; other site 530564009685 ATP binding site [chemical binding]; other site 530564009686 Q-loop/lid; other site 530564009687 ABC transporter signature motif; other site 530564009688 Walker B; other site 530564009689 D-loop; other site 530564009690 H-loop/switch region; other site 530564009691 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 530564009692 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 530564009693 dimer interface [polypeptide binding]; other site 530564009694 conserved gate region; other site 530564009695 putative PBP binding loops; other site 530564009696 ABC-ATPase subunit interface; other site 530564009697 ABC-type nitrate/sulfonate/bicarbonate transport systems, periplasmic components [Inorganic ion transport and metabolism]; Region: TauA; COG0715 530564009698 NMT1-like family; Region: NMT1_2; pfam13379 530564009699 Domain of unknown function (DUF4104); Region: DUF4104; pfam13372 530564009700 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 530564009701 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564009702 active site 530564009703 phosphorylation site [posttranslational modification] 530564009704 intermolecular recognition site; other site 530564009705 dimerization interface [polypeptide binding]; other site 530564009706 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564009707 Walker A motif; other site 530564009708 ATP binding site [chemical binding]; other site 530564009709 Walker B motif; other site 530564009710 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 530564009711 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 530564009712 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 530564009713 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 530564009714 dimer interface [polypeptide binding]; other site 530564009715 phosphorylation site [posttranslational modification] 530564009716 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 530564009717 ATP binding site [chemical binding]; other site 530564009718 Mg2+ binding site [ion binding]; other site 530564009719 G-X-G motif; other site 530564009720 Response regulator receiver domain; Region: Response_reg; pfam00072 530564009721 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564009722 active site 530564009723 phosphorylation site [posttranslational modification] 530564009724 intermolecular recognition site; other site 530564009725 dimerization interface [polypeptide binding]; other site 530564009726 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 530564009727 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564009728 active site 530564009729 phosphorylation site [posttranslational modification] 530564009730 intermolecular recognition site; other site 530564009731 dimerization interface [polypeptide binding]; other site 530564009732 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 530564009733 DNA binding site [nucleotide binding] 530564009734 Osmosensitive K+ channel histidine kinase [Signal transduction mechanisms]; Region: KdpD; COG2205 530564009735 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 530564009736 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 530564009737 Ligand Binding Site [chemical binding]; other site 530564009738 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 530564009739 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 530564009740 dimer interface [polypeptide binding]; other site 530564009741 phosphorylation site [posttranslational modification] 530564009742 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 530564009743 ATP binding site [chemical binding]; other site 530564009744 Mg2+ binding site [ion binding]; other site 530564009745 G-X-G motif; other site 530564009746 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 530564009747 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 530564009748 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 530564009749 Soluble P-type ATPase [General function prediction only]; Region: COG4087 530564009750 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 530564009751 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 530564009752 Sulfatase; Region: Sulfatase; pfam00884 530564009753 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 530564009754 Sulfatase; Region: Sulfatase; pfam00884 530564009755 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 530564009756 Sulfatase; Region: Sulfatase; pfam00884 530564009757 Ubiquitin-like proteins; Region: UBQ; cl00155 530564009758 charged pocket; other site 530564009759 hydrophobic patch; other site 530564009760 BNR repeat-like domain; Region: BNR_2; pfam13088 530564009761 BNR repeat-like domain; Region: BNR_2; pfam13088 530564009762 Cation/multidrug efflux pump [Defense mechanisms]; Region: AcrB; COG0841 530564009763 periplasmic multidrug efflux lipoprotein precursor; Reviewed; Region: PRK09578 530564009764 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 530564009765 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 530564009766 nucleoside/Zn binding site; other site 530564009767 dimer interface [polypeptide binding]; other site 530564009768 catalytic motif [active] 530564009769 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 530564009770 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 530564009771 Uncharacterized conserved protein (some members contain a von Willebrand factor type A (vWA) domain) [General function prediction only]; Region: COG1721 530564009772 Protein of unknown function DUF58; Region: DUF58; pfam01882 530564009773 MoxR-like ATPases [General function prediction only]; Region: COG0714 530564009774 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 530564009775 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 530564009776 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 530564009777 Trp docking motif [polypeptide binding]; other site 530564009778 active site 530564009779 PQQ-like domain; Region: PQQ_2; pfam13360 530564009780 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 530564009781 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 530564009782 Transcriptional regulators [Transcription]; Region: MarR; COG1846 530564009783 MarR family; Region: MarR_2; pfam12802 530564009784 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 530564009785 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 530564009786 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_13; cd08354 530564009787 putative metal binding site [ion binding]; other site 530564009788 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 530564009789 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 530564009790 Sulfatase; Region: Sulfatase; cl17466 530564009791 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 530564009792 methionine sulfoxide reductase B; Provisional; Region: PRK00222 530564009793 SelR domain; Region: SelR; pfam01641 530564009794 methionine sulfoxide reductase A; Provisional; Region: PRK14054 530564009795 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 530564009796 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564009797 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564009798 Primosomal replication protein priB and priC; Region: priB_priC; cl11483 530564009799 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564009800 Putative translation factor (SUA5) [Translation, ribosomal structure and biogenesis]; Region: SUA5; COG0009 530564009801 Putative GTP-binding controlling metal-binding; Region: SUA5; pfam03481 530564009802 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564009803 PII uridylyl-transferase; Provisional; Region: PRK05092 530564009804 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 530564009805 metal binding triad; other site 530564009806 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 530564009807 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 530564009808 Zn2+ binding site [ion binding]; other site 530564009809 Mg2+ binding site [ion binding]; other site 530564009810 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 530564009811 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 530564009812 Nitrogen regulatory protein PII [Amino acid transport and metabolism]; Region: GlnK; COG0347 530564009813 Nitrogen regulatory protein P-II; Region: P-II; smart00938 530564009814 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 530564009815 Cobalamin adenosyltransferase; Region: Cob_adeno_trans; pfam01923 530564009816 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 530564009817 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 530564009818 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 530564009819 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 530564009820 nudix motif; other site 530564009821 Prokaryotic RING finger family 1; Region: Prok-RING_1; pfam14446 530564009822 Prokaryotic RING finger family 1; Region: Prok-RING_1; pfam14446 530564009823 PHD-finger; Region: PHD; cl17445 530564009824 Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin...; Region: UBCc; cl00154 530564009825 E3 interaction residues; other site 530564009826 Ub thioester intermediate interaction residues; other site 530564009827 active site cysteine 530564009828 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 530564009829 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 530564009830 Dinucleotide-utilizing enzymes involved in molybdopterin and thiamine biosynthesis family 2 [Coenzyme metabolism]; Region: ThiF; COG0476 530564009831 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 530564009832 ATP binding site [chemical binding]; other site 530564009833 substrate interface [chemical binding]; other site 530564009834 Mpr1p, Pad1p N-terminal (MPN) domains; Region: MPN; cl13996 530564009835 Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin...; Region: UBCc; cl00154 530564009836 E3 interaction residues; other site 530564009837 Ub thioester intermediate interaction residues; other site 530564009838 active site cysteine 530564009839 WXG100 protein secretion system (Wss), protein YukD; Region: YukD; pfam08817 530564009840 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564009841 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 530564009842 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564009843 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564009844 Transglutaminase-like enzymes, putative cysteine proteases [Amino acid transport and metabolism]; Region: COG1305 530564009845 Transglutaminase-like superfamily; Region: Transglut_core; pfam01841 530564009846 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 530564009847 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 530564009848 Protein of unknown function (DUF1551); Region: DUF1551; pfam07585 530564009849 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564009850 Predicted hydrolase of the alpha/beta-hydrolase fold [General function prediction only]; Region: COG0429 530564009851 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK14481; cl10557 530564009852 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 530564009853 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 530564009854 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 530564009855 phosphopeptide binding site; other site 530564009856 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 530564009857 GAF domain; Region: GAF_3; pfam13492 530564009858 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564009859 Walker A motif; other site 530564009860 ATP binding site [chemical binding]; other site 530564009861 Walker B motif; other site 530564009862 arginine finger; other site 530564009863 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 530564009864 Sirohydrochlorin cobalt chelatase (CbiX) and sirohydrochlorin iron chelatase (SirB), N-terminal domain. SirB catalyzes the ferro-chelation of sirohydrochlorin to siroheme, the prosthetic group of sulfite and nitrite reductases. CbiX is a cobaltochelatase; Region: CbiX_SirB_N; cd03416 530564009865 putative active site [active] 530564009866 Class II Chelatase: a family of ATP-independent monomeric or homodimeric enzymes that catalyze the insertion of metal into protoporphyrin rings. This family includes protoporphyrin IX ferrochelatase (HemH), sirohydrochlorin ferrochelatase (SirB) and the...; Region: Chelatase_Class_II; cl02784 530564009867 active site 530564009868 carboxy-terminal protease; Provisional; Region: PRK11186 530564009869 C-terminal processing peptidase family S41; Region: Peptidase_S41; cl02526 530564009870 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 530564009871 protein binding site [polypeptide binding]; other site 530564009872 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 530564009873 Catalytic dyad [active] 530564009874 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 530564009875 Metal-dependent hydrolases of the beta-lactamase superfamily I [General function prediction only]; Region: PhnP; COG1235 530564009876 putative hydrolase; Provisional; Region: PRK02113 530564009877 SecA DEAD-like domain; Region: SecA_DEAD; smart00957 530564009878 SecA preprotein cross-linking domain; Region: SecA_PP_bind; pfam01043 530564009879 SEC-C motif; Region: SEC-C; pfam02810 530564009880 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 530564009881 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 530564009882 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564009883 2-keto-3-deoxy-6-phosphogluconate aldolase [Carbohydrate transport and metabolism]; Region: Eda; COG0800 530564009884 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 530564009885 active site 530564009886 intersubunit interface [polypeptide binding]; other site 530564009887 catalytic residue [active] 530564009888 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 530564009889 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 530564009890 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase; pfam01078 530564009891 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564009892 Walker A motif; other site 530564009893 ATP binding site [chemical binding]; other site 530564009894 Walker B motif; other site 530564009895 arginine finger; other site 530564009896 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 530564009897 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 530564009898 Zn2+ binding site [ion binding]; other site 530564009899 Mg2+ binding site [ion binding]; other site 530564009900 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cl00257 530564009901 IHF dimer interface [polypeptide binding]; other site 530564009902 IHF - DNA interface [nucleotide binding]; other site 530564009903 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 530564009904 PQQ-like domain; Region: PQQ_2; pfam13360 530564009905 Trp docking motif [polypeptide binding]; other site 530564009906 active site 530564009907 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564009908 binding surface 530564009909 TPR motif; other site 530564009910 PQQ-like domain; Region: PQQ_2; pfam13360 530564009911 Exonuclease-Endonuclease-Phosphatase (EEP) domain superfamily; Region: EEP; cl00490 530564009912 putative catalytic site [active] 530564009913 putative metal binding site [ion binding]; other site 530564009914 putative phosphate binding site [ion binding]; other site 530564009915 MepB protein; Region: MepB; cl01985 530564009916 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 530564009917 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 530564009918 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 530564009919 DNA binding residues [nucleotide binding] 530564009920 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 530564009921 metal ion-dependent adhesion site (MIDAS); other site 530564009922 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 530564009923 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 530564009924 TPR motif; other site 530564009925 binding surface 530564009926 Biopolymer transport proteins [Intracellular trafficking and secretion]; Region: TolQ; COG0811 530564009927 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 530564009928 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 530564009929 Biopolymer transport protein ExbD/TolR; Region: ExbD; pfam02472 530564009930 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 530564009931 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 530564009932 active site 530564009933 DNA binding site [nucleotide binding] 530564009934 Int/Topo IB signature motif; other site 530564009935 UDP-glucose 4-epimerase [Cell envelope biogenesis, outer membrane]; Region: GalE; COG1087 530564009936 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 530564009937 NAD binding site [chemical binding]; other site 530564009938 homodimer interface [polypeptide binding]; other site 530564009939 active site 530564009940 substrate binding site [chemical binding]; other site 530564009941 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 530564009942 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 530564009943 putative acyl-acceptor binding pocket; other site 530564009944 Domain of unknown function DUF87; Region: DUF87; pfam01935 530564009945 AAA-like domain; Region: AAA_10; pfam12846 530564009946 Superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodA; COG0605 530564009947 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 530564009948 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 530564009949 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 530564009950 ResB protein required for cytochrome c biosynthesis [Posttranslational modification, protein turnover, chaperones]; Region: ResB; cl09125 530564009951 Cytochrome C assembly protein; Region: Cytochrom_C_asm; cl00504 530564009952 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cl02931 530564009953 ligand binding site [chemical binding]; other site 530564009954 Helix-turn-helix domain; Region: HTH_17; pfam12728 530564009955 Predicted PP-loop superfamily ATPase [General function prediction only]; Region: COG0603 530564009956 Ligand Binding Site [chemical binding]; other site 530564009957 6-pyruvoyl tetrahydropterin synthase; Region: PTPS; pfam01242 530564009958 active site 530564009959 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 530564009960 Sulfatase; Region: Sulfatase; cl17466 530564009961 Uncharacterized conserved protein [Function unknown]; Region: COG1262 530564009962 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 530564009963 Gluconolactonase [Carbohydrate transport and metabolism]; Region: COG3386 530564009964 hypothetical protein; Provisional; Region: PRK13665 530564009965 Predicted tRNA(5-methylaminomethyl-2-thiouridylate) methyltransferase, contains the PP-loop ATPase domain [Translation, ribosomal structure and biogenesis]; Region: TrmU; COG0482 530564009966 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 530564009967 Ligand Binding Site [chemical binding]; other site 530564009968 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 530564009969 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 530564009970 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 530564009971 HSP70 interaction site [polypeptide binding]; other site 530564009972 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 530564009973 substrate binding site [polypeptide binding]; other site 530564009974 DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]; Region: DnaJ; COG0484 530564009975 dimer interface [polypeptide binding]; other site 530564009976 Ribonuclease P; Region: Ribonuclease_P; pfam00825 530564009977 Haemolytic domain; Region: Haemolytic; pfam01809 530564009978 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 530564009979 aspartyl/glutamyl-tRNA amidotransferase subunit C; Reviewed; Region: gatC; PRK00034 530564009980 Asp-tRNAAsn/Glu-tRNAGln amidotransferase A subunit and related amidases [Translation, ribosomal structure and biogenesis]; Region: GatA; COG0154 530564009981 aspartyl/glutamyl-tRNA amidotransferase subunit A; Reviewed; Region: gatA; PRK00012 530564009982 aspartyl/glutamyl-tRNA amidotransferase subunit B; Validated; Region: gatB; PRK05477 530564009983 GatB/GatE catalytic domain; Region: GatB_N; pfam02934 530564009984 GatB domain; Region: GatB_Yqey; smart00845 530564009985 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 530564009986 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 530564009987 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 530564009988 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 530564009989 dimerization interface 3.5A [polypeptide binding]; other site 530564009990 active site 530564009991 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 530564009992 This family is most closely related to the GT1 family of glycosyltransferases. cap1E in Streptococcus pneumoniae is required for the synthesis of type 1 capsular polysaccharides; Region: GT1_cap1E_like; cd03808 530564009993 putative ADP-binding pocket [chemical binding]; other site 530564009994 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 530564009995 Catalytic domain of Protein Kinases; Region: PKc; cd00180 530564009996 active site 530564009997 ATP binding site [chemical binding]; other site 530564009998 substrate binding site [chemical binding]; other site 530564009999 activation loop (A-loop); other site 530564010000 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 530564010001 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 530564010002 RecA-like NTPases. This family includes the NTP binding domain of F1 and V1 H+ATPases, DnaB and related helicases as well as bacterial RecA and related eukaryotic and archaeal recombinases. This group also includes bacterial conjugation proteins and...; Region: RecA-like_NTPases; cl17233 530564010003 Walker A motif; other site 530564010004 ATP binding site [chemical binding]; other site 530564010005 Walker B motif; other site 530564010006 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 530564010007 Colicin V production protein; Region: Colicin_V; pfam02674 530564010008 Predicted membrane-bound metal-dependent hydrolase (DUF457); Region: DUF457; pfam04307 530564010009 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 530564010010 putative active site [active] 530564010011 dimerization interface [polypeptide binding]; other site 530564010012 putative tRNAtyr binding site [nucleotide binding]; other site 530564010013 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 530564010014 catalytic core [active] 530564010015 Domain of unknown function DUF11; Region: DUF11; cl17728 530564010016 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 530564010017 aspartate aminotransferase; Provisional; Region: PRK05764 530564010018 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 530564010019 pyridoxal 5'-phosphate binding site [chemical binding]; other site 530564010020 homodimer interface [polypeptide binding]; other site 530564010021 catalytic residue [active] 530564010022 Protein of unknown function (DUF3040); Region: DUF3040; pfam11239 530564010023 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 530564010024 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 530564010025 Metal-binding active site; metal-binding site 530564010026 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 530564010027 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 530564010028 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 530564010029 A subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. Many of these band 7 domain-containing proteins are lipid raft-associated. Individual...; Region: Band_7_5; cd03408 530564010030 microbial_RNases. Ribonucleases (RNAses) cleave phosphodiester bonds in RNA and are essential for both non-specific RNA degradation and for numerous forms of RNA processing. The alignment contains fungal RNases (U2, T1, F1, Th, Pb, N1, and Ms) and...; Region: microbial_RNases; cl00212 530564010031 active site 530564010032 Barstar_evA4336-like contains uncharacterized sequences similar to the uncharacterized, predicted RNAase inhibitor evA4336 found in Azoarcus sp. EvN1. This is a subfamily of the Barstar family of RNAase inhibitors. Barstar is an intracellular inhibitor...; Region: Barstar_evA4336-like; cd05141 530564010033 putative RNAase interaction site [polypeptide binding]; other site 530564010034 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 530564010035 beta-ketoacyl-acyl-carrier-protein synthase II; Region: fabF; TIGR03150 530564010036 dimer interface [polypeptide binding]; other site 530564010037 active site 530564010038 Acyl carrier protein [Lipid metabolism / Secondary metabolites biosynthesis, transport, and catabolism]; Region: AcpP; COG0236 530564010039 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 530564010040 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 530564010041 Phytoene dehydrogenase and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG1233 530564010042 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 530564010043 Nitrate and nitrite sensing; Region: NIT; pfam08376 530564010044 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 530564010045 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 530564010046 Enoyl-(Acyl carrier protein) reductase; Region: adh_short_C2; pfam13561 530564010047 NAD(P) binding site [chemical binding]; other site 530564010048 active site 530564010049 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09258 530564010050 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 530564010051 active site 530564010052 excinuclease ABC subunit B; Provisional; Region: PRK05298 530564010053 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 530564010054 ATP binding site [chemical binding]; other site 530564010055 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 530564010056 nucleotide binding region [chemical binding]; other site 530564010057 ATP-binding site [chemical binding]; other site 530564010058 Ultra-violet resistance protein B; Region: UvrB; pfam12344 530564010059 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 530564010060 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 530564010061 RNA polymerase sigma factor RpoE; Provisional; Region: PRK09652 530564010062 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 530564010063 DNA binding residues [nucleotide binding] 530564010064 Cytochrome c; Region: Cytochrom_C; cl11414 530564010065 putative heme-binding domain, Pirellula/Verrucomicrobium type; Region: CxxCH_TIGR02603 530564010066 Cytochrome C oxidase, cbb3-type, subunit III; Region: Cytochrome_CBB3; pfam13442 530564010067 Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of...; Region: LamG; cd00110 530564010068 Domain of unknown function (DUF2341); Region: DUF2341; pfam10102 530564010069 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 530564010070 Domain of unknown function (DUF303); Region: DUF303; pfam03629 530564010071 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 530564010072 Sulfatase; Region: Sulfatase; pfam00884 530564010073 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 530564010074 MPT binding site; other site 530564010075 trimer interface [polypeptide binding]; other site 530564010076 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 530564010077 ATP binding site [chemical binding]; other site 530564010078 Mg2+ binding site [ion binding]; other site 530564010079 G-X-G motif; other site 530564010080 xylose isomerase; Provisional; Region: PRK05474 530564010081 xylose isomerase; Region: xylose_isom_A; TIGR02630 530564010082 haloalkane dehalogenase; Provisional; Region: PRK03204 530564010083 ATP:dephospho-CoA triphosphoribosyl transferase; Region: CitG; pfam01874 530564010084 6-pyruvoyl-tetrahydropterin synthase [Coenzyme metabolism]; Region: COG0720 530564010085 Ammonia permease [Inorganic ion transport and metabolism]; Region: AmtB; COG0004 530564010086 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 530564010087 dimer interface [polypeptide binding]; other site 530564010088 phosphorylation site [posttranslational modification] 530564010089 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 530564010090 ATP binding site [chemical binding]; other site 530564010091 Mg2+ binding site [ion binding]; other site 530564010092 G-X-G motif; other site 530564010093 FOG: CheY-like receiver [Signal transduction mechanisms]; Region: CheY; COG0784 530564010094 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564010095 active site 530564010096 phosphorylation site [posttranslational modification] 530564010097 intermolecular recognition site; other site 530564010098 dimerization interface [polypeptide binding]; other site 530564010099 Predicted inhibitor of MCP methylation, homolog of CheC [Cell motility and secretion]; Region: COG1406 530564010100 Chemotaxis phosphatase CheX; Region: CheX; pfam13690 530564010101 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 530564010102 FliG C-terminal domain; Region: FliG_C; pfam01706 530564010103 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 530564010104 MutS domain I; Region: MutS_I; pfam01624 530564010105 MutS domain II; Region: MutS_II; pfam05188 530564010106 MutS domain III; Region: MutS_III; pfam05192 530564010107 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 530564010108 Walker A/P-loop; other site 530564010109 ATP binding site [chemical binding]; other site 530564010110 Q-loop/lid; other site 530564010111 ABC transporter signature motif; other site 530564010112 Walker B; other site 530564010113 D-loop; other site 530564010114 H-loop/switch region; other site 530564010115 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 530564010116 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 530564010117 phosphopeptide binding site; other site 530564010118 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 530564010119 Helix-hairpin-helix motif; Region: HHH_3; pfam12836 530564010120 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 530564010121 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 530564010122 3-beta hydroxysteroid dehydrogenase/isomerase family; Region: 3Beta_HSD; pfam01073 530564010123 NAD(P) binding site [chemical binding]; other site 530564010124 active site 530564010125 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 530564010126 oligomeric interface; other site 530564010127 putative active site [active] 530564010128 homodimer interface [polypeptide binding]; other site 530564010129 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 530564010130 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 530564010131 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 530564010132 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 530564010133 active site 530564010134 L-alanine-DL-glutamate epimerase and related enzymes of enolase superfamily [Cell envelope biogenesis, outer membrane / General function prediction only]; Region: COG4948 530564010135 Mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic residues; Region: MR_like; cd03316 530564010136 active site pocket [active] 530564010137 NPCBM/NEW2 domain; Region: NPCBM; cl07060 530564010138 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564010139 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564010140 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564010141 ATPase involved in DNA repair [DNA replication, recombination, and repair]; Region: SbcC; COG0419 530564010142 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 530564010143 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 530564010144 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 530564010145 DNA binding residues [nucleotide binding] 530564010146 Response regulator receiver domain; Region: Response_reg; pfam00072 530564010147 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564010148 active site 530564010149 phosphorylation site [posttranslational modification] 530564010150 intermolecular recognition site; other site 530564010151 dimerization interface [polypeptide binding]; other site 530564010152 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 530564010153 PAS fold; Region: PAS_3; pfam08447 530564010154 putative active site [active] 530564010155 heme pocket [chemical binding]; other site 530564010156 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 530564010157 ATP binding site [chemical binding]; other site 530564010158 Mg2+ binding site [ion binding]; other site 530564010159 G-X-G motif; other site 530564010160 Response regulator receiver domain; Region: Response_reg; pfam00072 530564010161 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564010162 active site 530564010163 phosphorylation site [posttranslational modification] 530564010164 intermolecular recognition site; other site 530564010165 dimerization interface [polypeptide binding]; other site 530564010166 GAF domain; Region: GAF; cl17456 530564010167 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 530564010168 PAS fold; Region: PAS_3; pfam08447 530564010169 putative active site [active] 530564010170 heme pocket [chemical binding]; other site 530564010171 nitrogen fixation negative regulator NifL; Region: nifL_nitrog; TIGR02938 530564010172 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 530564010173 putative active site [active] 530564010174 heme pocket [chemical binding]; other site 530564010175 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 530564010176 dimer interface [polypeptide binding]; other site 530564010177 phosphorylation site [posttranslational modification] 530564010178 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 530564010179 ATP binding site [chemical binding]; other site 530564010180 Mg2+ binding site [ion binding]; other site 530564010181 G-X-G motif; other site 530564010182 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 530564010183 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 530564010184 Bifunctional nuclease; Region: DNase-RNase; pfam02577 530564010185 tRNA threonylcarbamoyl adenosine modification protein YeaZ; Region: T6A_YeaZ; TIGR03725 530564010186 Glycoprotease family; Region: Peptidase_M22; pfam00814 530564010187 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 530564010188 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 530564010189 active site 530564010190 metal binding site [ion binding]; metal-binding site 530564010191 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cd00838 530564010192 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 530564010193 active site 530564010194 metal binding site [ion binding]; metal-binding site 530564010195 Diadenosine tetraphosphatase and related serine/threonine protein phosphatases [Signal transduction mechanisms]; Region: ApaH; COG0639 530564010196 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564010197 Transthyretin-like family; Region: DUF290; pfam01060 530564010198 Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]; Region: DegQ; COG0265 530564010199 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 530564010200 membrane protein insertase, YidC/Oxa1 family, N-terminal domain; Region: yidC_nterm; TIGR03593 530564010201 60Kd inner membrane protein; Region: 60KD_IMP; pfam02096 530564010202 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 530564010203 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 530564010204 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 530564010205 G1 box; other site 530564010206 GTP/Mg2+ binding site [chemical binding]; other site 530564010207 G2 box; other site 530564010208 Switch I region; other site 530564010209 G3 box; other site 530564010210 Switch II region; other site 530564010211 G4 box; other site 530564010212 G5 box; other site 530564010213 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 530564010214 aspartate kinase; Provisional; Region: PRK07431 530564010215 AAK_AKii-LysC-BS: Amino Acid Kinase Superfamily (AAK), AKii; this CD includes the N-terminal catalytic aspartokinase (AK) domain of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis 168, and the lysine plus threonine-sensitive...; Region: AAK_AKii-LysC-BS; cd04261 530564010216 putative nucleotide binding site [chemical binding]; other site 530564010217 putative catalytic residues [active] 530564010218 putative Mg ion binding site [ion binding]; other site 530564010219 putative aspartate binding site [chemical binding]; other site 530564010220 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 530564010221 putative allosteric regulatory site; other site 530564010222 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 530564010223 putative allosteric regulatory residue; other site 530564010224 ACT domains of the lysine-sensitive aspartokinase isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related proteins; Region: ACT_AKii-LysC-BS-like_1; cd04913 530564010225 putative allosteric regulatory site; other site 530564010226 ACT domains of the lysine-sensitive, aspartokinase (AK) isoenzyme AKII of Bacillus subtilis (BS) strain 168 and related domains; Region: ACT_AKii-LysC-BS-like_2; cd04936 530564010227 putative allosteric regulatory residue; other site 530564010228 cofactor-independent phosphoglycerate mutase; Provisional; Region: PRK04200 530564010229 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: PhosphMutase; cl17294 530564010230 homoserine dehydrogenase; Provisional; Region: PRK06349 530564010231 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 530564010232 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 530564010233 ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related domains; Region: ACT_HSDH-Hom; cd04881 530564010234 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 530564010235 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 530564010236 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 530564010237 trimer interface [polypeptide binding]; other site 530564010238 active site 530564010239 UDP-GlcNAc binding site [chemical binding]; other site 530564010240 lipid binding site [chemical binding]; lipid-binding site 530564010241 Protein of unknown function (DUF1009); Region: DUF1009; pfam06230 530564010242 Uncharacterized conserved protein [Function unknown]; Region: COG4278 530564010243 TIGR04222 domain; Region: near_uncomplex 530564010244 non-metazoan 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_Sc; cd01414 530564010245 ATP binding site [chemical binding]; other site 530564010246 active site 530564010247 substrate binding site [chemical binding]; other site 530564010248 Glycosyl hydrolase family 10; Region: Glyco_hydro_10; cl01495 530564010249 SMP-30/Gluconolaconase/LRE-like region; Region: SGL; pfam08450 530564010250 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 530564010251 anthranilate phosphoribosyltransferase; Provisional; Region: trpD; PRK00188 530564010252 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 530564010253 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 530564010254 Inosine-uridine preferring nucleoside hydrolase; Region: IU_nuc_hydro; pfam01156 530564010255 active site 530564010256 aldose 1-epimerase superfamily; Region: Aldose_epim; cd01081 530564010257 active site 530564010258 catalytic residues [active] 530564010259 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 530564010260 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 530564010261 Ligand binding site; other site 530564010262 Putative Catalytic site; other site 530564010263 DXD motif; other site 530564010264 Secreted and surface protein containing fasciclin-like repeats [Cell envelope biogenesis, outer membrane]; Region: COG2335 530564010265 Fasciclin domain; Region: Fasciclin; pfam02469 530564010266 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 530564010267 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 530564010268 NAD(P) binding site [chemical binding]; other site 530564010269 active site 530564010270 Peroxiredoxin (PRX)-like 2 family; hypothetical proteins that show sequence similarity to PRXs. Members of this group contain a CXXC motif, similar to TRX. The second cysteine in the motif corresponds to the peroxidatic cysteine of PRX, however, these...; Region: PRX_like2; cd02970 530564010271 putative catalytic residues [active] 530564010272 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 530564010273 CoA binding domain; Region: CoA_binding; pfam02629 530564010274 CoA-ligase; Region: Ligase_CoA; pfam00549 530564010275 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 530564010276 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 530564010277 CoA-ligase; Region: Ligase_CoA; pfam00549 530564010278 3-hydroxybutyrate dehydrogenase; Provisional; Region: PRK12429 530564010279 classical (c) SDRs; Region: SDR_c; cd05233 530564010280 NAD(P) binding site [chemical binding]; other site 530564010281 active site 530564010282 Phosphoenolpyruvate:glucose-phosphotransferase regulator; Region: MtfA; pfam06167 530564010283 TPR repeat; Region: TPR_11; pfam13414 530564010284 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564010285 TPR motif; other site 530564010286 binding surface 530564010287 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564010288 binding surface 530564010289 TPR motif; other site 530564010290 TPR repeat; Region: TPR_11; pfam13414 530564010291 malate dehydrogenase; Reviewed; Region: PRK06223 530564010292 L-lactate dehydrogenase-like malate dehydrogenase proteins; Region: LDH-like_MDH; cd01339 530564010293 NAD(P) binding site [chemical binding]; other site 530564010294 dimer interface [polypeptide binding]; other site 530564010295 tetramer (dimer of dimers) interface [polypeptide binding]; other site 530564010296 substrate binding site [chemical binding]; other site 530564010297 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 530564010298 Nudix hydrolase is a superfamily of enzymes found in all three kingdoms of life, and it catalyzes the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+...; Region: Nudix_Hydrolase; cl00447 530564010299 nudix motif; other site 530564010300 TPR repeat; Region: TPR_11; pfam13414 530564010301 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564010302 binding surface 530564010303 TPR motif; other site 530564010304 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 530564010305 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 530564010306 dimer interface [polypeptide binding]; other site 530564010307 phosphorylation site [posttranslational modification] 530564010308 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 530564010309 ATP binding site [chemical binding]; other site 530564010310 Mg2+ binding site [ion binding]; other site 530564010311 G-X-G motif; other site 530564010312 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 530564010313 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564010314 active site 530564010315 phosphorylation site [posttranslational modification] 530564010316 intermolecular recognition site; other site 530564010317 dimerization interface [polypeptide binding]; other site 530564010318 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564010319 Walker A motif; other site 530564010320 ATP binding site [chemical binding]; other site 530564010321 Walker B motif; other site 530564010322 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 530564010323 flagellar basal body rod protein FlgB; Provisional; Region: flgB; PRK12621 530564010324 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 530564010325 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 530564010326 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 530564010327 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 530564010328 Flagellar basal body M-ring protein [Cell motility and secretion]; Region: fliF; COG1766 530564010329 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 530564010330 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 530564010331 flagellar motor switch protein G; Validated; Region: fliG; PRK05686 530564010332 FliG C-terminal domain; Region: FliG_C; pfam01706 530564010333 Flagellar assembly protein FliH; Region: FliH; pfam02108 530564010334 flagellar protein export ATPase FliI; Region: FliI_clade1; TIGR03496 530564010335 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 530564010336 Walker A motif/ATP binding site; other site 530564010337 Walker B motif; other site 530564010338 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK07720 530564010339 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 530564010340 phosphodiesterase; Provisional; Region: PRK12704 530564010341 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 530564010342 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 530564010343 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 530564010344 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 530564010345 Flagellar protein (FlbD); Region: FlbD; pfam06289 530564010346 MotA/TolQ/ExbB proton channel family; Region: MotA_ExbB; cl00568 530564010347 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 530564010348 Flagellar motor protein [Cell motility and secretion]; Region: MotB; COG1360 530564010349 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 530564010350 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 530564010351 ligand binding site [chemical binding]; other site 530564010352 Flagellar basal body-associated protein FliL; Region: FliL; cl00681 530564010353 flagellar motor switch protein FliN; Region: fliN; TIGR02480 530564010354 flagellar biosynthetic protein FliO; Region: FliO_TIGR; TIGR03500 530564010355 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 530564010356 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 530564010357 Bacterial export proteins, family 1; Region: Bac_export_1; cl00734 530564010358 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 530564010359 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 530564010360 Coenzyme F420-dependent N5,N10-methylene tetrahydromethanopterin reductase and related flavin-dependent oxidoreductases [Energy production and conversion]; Region: COG2141 530564010361 probable oxidoreductase, LLM family; Region: LLM_2I7G; TIGR03858 530564010362 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 530564010363 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: fabG; PRK07231 530564010364 classical (c) SDRs; Region: SDR_c; cd05233 530564010365 NAD(P) binding site [chemical binding]; other site 530564010366 active site 530564010367 2-phosphosulpholactate phosphatase; Region: 2-ph_phosp; pfam04029 530564010368 glycyl-tRNA synthetase; Provisional; Region: PRK04173 530564010369 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 530564010370 motif 1; other site 530564010371 Glycyl-tRNA synthetase (GlyRS)-like class II core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes. It is responsible for the attachment of glycine to the 3...; Region: GlyRS-like_core; cd00774 530564010372 active site 530564010373 motif 2; other site 530564010374 motif 3; other site 530564010375 GlyRS Glycyl-anticodon binding domain. GlyRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: GlyRS_anticodon; cd00858 530564010376 anticodon binding site; other site 530564010377 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 530564010378 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 530564010379 Metal-binding active site; metal-binding site 530564010380 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 530564010381 Prenyltransferase-like; Region: Prenyltrans_1; pfam13243 530564010382 Phosphate-selective porin O and P; Region: Porin_O_P; pfam07396 530564010383 Pyruvate kinase [Carbohydrate transport and metabolism]; Region: PykF; COG0469 530564010384 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 530564010385 domain interfaces; other site 530564010386 active site 530564010387 Domain of Unknown Function (DUF1080); Region: DUF1080; pfam06439 530564010388 2-isopropylmalate synthase; Validated; Region: PRK00915 530564010389 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 530564010390 active site 530564010391 catalytic residues [active] 530564010392 metal binding site [ion binding]; metal-binding site 530564010393 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; smart00917 530564010394 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564010395 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cl17698 530564010396 BNR repeat-like domain; Region: BNR_2; pfam13088 530564010397 Asp-box motif; other site 530564010398 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 530564010399 BNR repeat-like domain; Region: BNR_2; pfam13088 530564010400 Asp-box motif; other site 530564010401 SGNH_hydrolase, or GDSL_hydrolase, is a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site closely...; Region: SGNH_hydrolase; cl01053 530564010402 active site 530564010403 oxyanion hole [active] 530564010404 Protein of unknown function (DUF1598); Region: DUF1598; pfam07643 530564010405 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 530564010406 Beta-eliminating lyase; Region: Beta_elim_lyase; pfam01212 530564010407 tetramer interface [polypeptide binding]; other site 530564010408 pyridoxal 5'-phosphate binding site [chemical binding]; other site 530564010409 catalytic residue [active] 530564010410 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 530564010411 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 530564010412 substrate-cofactor binding pocket; other site 530564010413 pyridoxal 5'-phosphate binding site [chemical binding]; other site 530564010414 catalytic residue [active] 530564010415 Threonine dehydrogenase; Region: TDH; cd05281 530564010416 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 530564010417 structural Zn binding site [ion binding]; other site 530564010418 catalytic Zn binding site [ion binding]; other site 530564010419 tetramer interface [polypeptide binding]; other site 530564010420 NADP binding site [chemical binding]; other site 530564010421 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 530564010422 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 530564010423 non-specific DNA binding site [nucleotide binding]; other site 530564010424 salt bridge; other site 530564010425 sequence-specific DNA binding site [nucleotide binding]; other site 530564010426 Cupin domain; Region: Cupin_2; pfam07883 530564010427 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 530564010428 histidinol dehydrogenase; Region: hisD; TIGR00069 530564010429 NAD binding site [chemical binding]; other site 530564010430 dimerization interface [polypeptide binding]; other site 530564010431 product binding site; other site 530564010432 substrate binding site [chemical binding]; other site 530564010433 zinc binding site [ion binding]; other site 530564010434 catalytic residues [active] 530564010435 Histidinol-phosphate/aromatic aminotransferase and cobyric acid decarboxylase [Amino acid transport and metabolism]; Region: HisC; COG0079 530564010436 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 530564010437 pyridoxal 5'-phosphate binding site [chemical binding]; other site 530564010438 homodimer interface [polypeptide binding]; other site 530564010439 catalytic residue [active] 530564010440 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 530564010441 putative active site pocket [active] 530564010442 4-fold oligomerization interface [polypeptide binding]; other site 530564010443 metal binding residues [ion binding]; metal-binding site 530564010444 3-fold/trimer interface [polypeptide binding]; other site 530564010445 SMI1 / KNR4 family (SUKH-1); Region: SMI1_KNR4; pfam09346 530564010446 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 530564010447 Sulfatase; Region: Sulfatase; cl17466 530564010448 6-phosphofructokinase [Carbohydrate transport and metabolism]; Region: PfkA; COG0205 530564010449 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 530564010450 active site 530564010451 ADP/pyrophosphate binding site [chemical binding]; other site 530564010452 dimerization interface [polypeptide binding]; other site 530564010453 allosteric effector site; other site 530564010454 fructose-1,6-bisphosphate binding site; other site 530564010455 glycine oxidase ThiO; Region: thiamin_ThiO; TIGR02352 530564010456 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 530564010457 transferase 1, rSAM/selenodomain-associated; Region: glyco_like_cofC; TIGR04282 530564010458 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 530564010459 Catalytic domain of Protein Kinases; Region: PKc; cd00180 530564010460 active site 530564010461 ATP binding site [chemical binding]; other site 530564010462 substrate binding site [chemical binding]; other site 530564010463 activation loop (A-loop); other site 530564010464 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 530564010465 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 530564010466 Peptidase MA superfamily; Region: Peptidase_MA_2; pfam13485 530564010467 TIGR00268 family protein; Region: TIGR00268 530564010468 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily. Adenine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_I; cd01990 530564010469 Ligand Binding Site [chemical binding]; other site 530564010470 Rho termination factor, N-terminal domain; Region: Rho_N; cl06505 530564010471 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3330 530564010472 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 530564010473 F0F1-type ATP synthase, subunit c/Archaeal/vacuolar-type H+-ATPase, subunit K [Energy production and conversion]; Region: AtpE; COG0636 530564010474 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 530564010475 ATP synthase B/B' CF(0); Region: ATP-synt_B; cl17192 530564010476 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 530564010477 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 530564010478 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 530564010479 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 530564010480 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 530564010481 beta subunit interaction interface [polypeptide binding]; other site 530564010482 Walker A motif; other site 530564010483 ATP binding site [chemical binding]; other site 530564010484 Walker B motif; other site 530564010485 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 530564010486 Tic20-like protein; Region: Tic20; pfam09685 530564010487 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 530564010488 core domain interface [polypeptide binding]; other site 530564010489 delta subunit interface [polypeptide binding]; other site 530564010490 epsilon subunit interface [polypeptide binding]; other site 530564010491 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 530564010492 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 530564010493 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 530564010494 alpha subunit interaction interface [polypeptide binding]; other site 530564010495 Walker A motif; other site 530564010496 ATP binding site [chemical binding]; other site 530564010497 Walker B motif; other site 530564010498 inhibitor binding site; inhibition site 530564010499 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 530564010500 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK01474 530564010501 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 530564010502 gamma subunit interface [polypeptide binding]; other site 530564010503 epsilon subunit interface [polypeptide binding]; other site 530564010504 LBP interface [polypeptide binding]; other site 530564010505 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cl00062 530564010506 SPFH domain / Band 7 family; Region: Band_7; pfam01145 530564010507 SPFH domain / Band 7 family; Region: Band_7; pfam01145 530564010508 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 530564010509 trimer interface [polypeptide binding]; other site 530564010510 active site 530564010511 substrate binding site [chemical binding]; other site 530564010512 CoA binding site [chemical binding]; other site 530564010513 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 530564010514 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 530564010515 catalytic residues [active] 530564010516 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13141 530564010517 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 530564010518 putative active site [active] 530564010519 oxyanion strand; other site 530564010520 catalytic triad [active] 530564010521 Domain of unknown function (DUF303); Region: DUF303; pfam03629 530564010522 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564010523 TPR motif; other site 530564010524 binding surface 530564010525 Peptidase_C39 like family; Region: Peptidase_C39_2; pfam13529 530564010526 putative active site [active] 530564010527 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 530564010528 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564010529 TPR motif; other site 530564010530 binding surface 530564010531 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564010532 TPR motif; other site 530564010533 binding surface 530564010534 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564010535 TPR motif; other site 530564010536 putative PEP-CTERM system TPR-repeat lipoprotein; Region: PEP_TPR_lipo; TIGR02917 530564010537 binding surface 530564010538 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564010539 TPR motif; other site 530564010540 binding surface 530564010541 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564010542 TPR motif; other site 530564010543 Uncharacterized conserved protein (DUF2293); Region: DUF2293; pfam10056 530564010544 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 530564010545 SEC-C motif; Region: SEC-C; pfam02810 530564010546 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 530564010547 putative metal binding site [ion binding]; other site 530564010548 Methyltransferase domain; Region: Methyltransf_23; pfam13489 530564010549 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 530564010550 S-adenosylmethionine binding site [chemical binding]; other site 530564010551 Cupin domain; Region: Cupin_2; cl17218 530564010552 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 530564010553 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 530564010554 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 530564010555 DNA polymerase III subunits gamma and tau; Provisional; Region: PRK14963 530564010556 Domain of unknown function (DUF932); Region: DUF932; cl12129 530564010557 AAA domain; Region: AAA_21; pfam13304 530564010558 AAA domain; Region: AAA_21; pfam13304 530564010559 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 530564010560 Q-loop/lid; other site 530564010561 ABC transporter signature motif; other site 530564010562 Walker B; other site 530564010563 D-loop; other site 530564010564 H-loop/switch region; other site 530564010565 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 530564010566 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 530564010567 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 530564010568 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 530564010569 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cl00427 530564010570 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 530564010571 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 530564010572 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 530564010573 ATP binding site [chemical binding]; other site 530564010574 putative Mg++ binding site [ion binding]; other site 530564010575 Helix-Turn-Helix DNA binding domain of truncated MerR-like proteins; Region: HTH_MerR-trunc; cd04762 530564010576 DNA binding residues [nucleotide binding] 530564010577 Predicted transcriptional regulator [Transcription]; Region: COG2378 530564010578 HTH domain; Region: HTH_11; pfam08279 530564010579 WYL domain; Region: WYL; pfam13280 530564010580 Peptidylarginine deiminase and related enzymes [Amino acid transport and metabolism]; Region: COG2957; cl01113 530564010581 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 530564010582 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 530564010583 putative acyl-acceptor binding pocket; other site 530564010584 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 530564010585 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 530564010586 S-adenosylmethionine binding site [chemical binding]; other site 530564010587 Cytochrome P450 [Secondary metabolites biosynthesis, transport, and catabolism]; Region: CypX; COG2124 530564010588 Cytochrome P450; Region: p450; cl12078 530564010589 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 530564010590 Endonuclease I; Region: Endonuclease_1; pfam04231 530564010591 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 530564010592 DNA/RNA endonuclease G, NUC1 [Nucleotide transport and metabolism]; Region: NUC1; COG1864 530564010593 DNA/RNA non-specific endonuclease; Region: Endonuclease_NS; smart00892 530564010594 active site 530564010595 substrate binding site [chemical binding]; other site 530564010596 Mg2+ binding site [ion binding]; other site 530564010597 Peptidase domain in the S8 and S53 families; Region: Peptidases_S8_S53; cl10459 530564010598 active site 530564010599 catalytic residues [active] 530564010600 Lipase (class 3). Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation," the...; Region: Lipase_3; cd00519 530564010601 active site flap/lid [active] 530564010602 nucleophilic elbow; other site 530564010603 catalytic triad [active] 530564010604 NB-ARC domain; Region: NB-ARC; pfam00931 530564010605 Tetratricopeptide repeat; Region: TPR_12; pfam13424 530564010606 Tetratricopeptide repeat; Region: TPR_12; pfam13424 530564010607 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 530564010608 Endonuclease I; Region: Endonuclease_1; pfam04231 530564010609 Predicted exonuclease of the beta-lactamase fold involved in RNA processing [Translation, ribosomal structure and biogenesis]; Region: YSH1; COG1236 530564010610 Beta-lactamase superfamily domain; Region: Lactamase_B_2; pfam12706 530564010611 RNA-metabolising metallo-beta-lactamase; Region: RMMBL; pfam07521 530564010612 SIR2-like domain; Region: SIR2_2; pfam13289 530564010613 GAF domain; Region: GAF_2; pfam13185 530564010614 HTH domain; Region: HTH_11; cl17392 530564010615 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 530564010616 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564010617 binding surface 530564010618 TPR motif; other site 530564010619 Tetratricopeptide repeat; Region: TPR_9; pfam13371 530564010620 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564010621 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 530564010622 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 530564010623 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 530564010624 active site 530564010625 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 530564010626 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 530564010627 carboxyltransferase (CT) interaction site; other site 530564010628 biotinylation site [posttranslational modification]; other site 530564010629 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 530564010630 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 530564010631 ATP-grasp domain; Region: ATP-grasp_4; cl17255 530564010632 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 530564010633 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 530564010634 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 530564010635 dihydroorotase; Validated; Region: pyrC; PRK09357 530564010636 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 530564010637 Dihydroorotase (DHOase), subgroup IIa; DHOases catalyze the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in pyrimidine biosynthesis. This subgroup also contains proteins that lack the active site, like unc-33, a C; Region: DHOase_IIa; cd01317 530564010638 active site 530564010639 aspartate carbamoyltransferase catalytic subunit; Provisional; Region: pyrB; PRK00856 530564010640 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 530564010641 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 530564010642 SGNH_hydrolase subfamily. SGNH hydrolases are a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its active site...; Region: SGNH_hydrolase_like_2; cd01834 530564010643 active site 530564010644 catalytic triad [active] 530564010645 oxyanion hole [active] 530564010646 Stress responsive A/B Barrel Domain; Region: Dabb; smart00886 530564010647 Nitrogen regulatory protein P-II; Region: P-II; pfam00543 530564010648 Nitrogen regulatory protein P-II; Region: P-II; smart00938 530564010649 Ammonium Transporter Family; Region: Ammonium_transp; cl03012 530564010650 Outer membrane protein family (DUF1597); Region: DUF1597; pfam07642 530564010651 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 530564010652 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 530564010653 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 530564010654 transcription antitermination protein NusB; Reviewed; Region: nusB; PRK00202 530564010655 putative RNA binding site [nucleotide binding]; other site 530564010656 Protein kinase domain; Region: Pkinase; pfam00069 530564010657 Catalytic domain of Protein Kinases; Region: PKc; cd00180 530564010658 active site 530564010659 ATP binding site [chemical binding]; other site 530564010660 substrate binding site [chemical binding]; other site 530564010661 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 530564010662 activation loop (A-loop); other site 530564010663 activation loop (A-loop); other site 530564010664 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 530564010665 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564010666 Walker A motif; other site 530564010667 ATP binding site [chemical binding]; other site 530564010668 Walker B motif; other site 530564010669 arginine finger; other site 530564010670 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 530564010671 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 530564010672 NAD-dependent aldehyde dehydrogenases [Energy production and conversion]; Region: PutA; COG1012 530564010673 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 530564010674 NAD(P) binding site [chemical binding]; other site 530564010675 catalytic residues [active] 530564010676 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 530564010677 Putative addiction module component; Region: Unstab_antitox; pfam09720 530564010678 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 530564010679 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 530564010680 active site 530564010681 metal binding site [ion binding]; metal-binding site 530564010682 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 530564010683 Trp docking motif [polypeptide binding]; other site 530564010684 active site 530564010685 PQQ-like domain; Region: PQQ_2; pfam13360 530564010686 Coproporphyrinogen III oxidase and related Fe-S oxidoreductases [Coenzyme metabolism]; Region: HemN; COG0635 530564010687 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 530564010688 FeS/SAM binding site; other site 530564010689 HemN C-terminal domain; Region: HemN_C; pfam06969 530564010690 glycine cleavage system protein H; Provisional; Region: PRK13380 530564010691 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 530564010692 lipoyl attachment site [posttranslational modification]; other site 530564010693 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 530564010694 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 530564010695 Sulfatase; Region: Sulfatase; pfam00884 530564010696 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 530564010697 ligand binding site [chemical binding]; other site 530564010698 Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon) [Cell envelope biogenesis, outer membrane / Translation, ribosomal structure...; Region: GCD1; COG1208 530564010699 G1P_cytidylyltransferase catalyzes the production of CDP-D-Glucose; Region: G1P_cytidylyltransferase; cd02524 530564010700 substrate binding site; other site 530564010701 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 530564010702 CDP-glucose 4,6-dehydratase; Region: CDP_4_6_dhtase; TIGR02622 530564010703 NAD(P) binding site [chemical binding]; other site 530564010704 active site 530564010705 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 530564010706 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 530564010707 NAD(P) binding site [chemical binding]; other site 530564010708 active site 530564010709 lipopolysaccharide biosynthesis protein RfbH; Provisional; Region: PRK15407 530564010710 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 530564010711 inhibitor-cofactor binding pocket; inhibition site 530564010712 pyridoxal 5'-phosphate binding site [chemical binding]; other site 530564010713 catalytic residue [active] 530564010714 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 530564010715 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 530564010716 Ligand binding site; other site 530564010717 Putative Catalytic site; other site 530564010718 DXD motif; other site 530564010719 Glucosyl transferase GtrII; Region: Glucos_trans_II; cl10304 530564010720 TadE-like protein; Region: TadE; pfam07811 530564010721 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cd00198 530564010722 metal ion-dependent adhesion site (MIDAS); other site 530564010723 TadE-like protein; Region: TadE; pfam07811 530564010724 ABC-type molybdate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ModA; COG0725 530564010725 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 530564010726 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 530564010727 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 530564010728 putative PBP binding loops; other site 530564010729 ABC-ATPase subunit interface; other site 530564010730 Predicted ATPase involved in cell division [Cell division and chromosome partitioning]; Region: FtsE; COG2884 530564010731 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 530564010732 Walker A/P-loop; other site 530564010733 ATP binding site [chemical binding]; other site 530564010734 Q-loop/lid; other site 530564010735 ABC transporter signature motif; other site 530564010736 Walker B; other site 530564010737 D-loop; other site 530564010738 H-loop/switch region; other site 530564010739 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 530564010740 4-hydroxythreonine-4-phosphate dehydrogenase; Region: pdxA; TIGR00557 530564010741 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cl11493 530564010742 PQQ-like domain; Region: PQQ_2; pfam13360 530564010743 Trp docking motif [polypeptide binding]; other site 530564010744 active site 530564010745 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564010746 Protein of unknown function (DUF3386); Region: DUF3386; pfam11866 530564010747 mutatrotase, YjhT family; Region: muta_rot_YjhT; TIGR03547 530564010748 Kelch domain; Region: Kelch; smart00612 530564010749 Kelch motif; Region: Kelch_1; pfam01344 530564010750 PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated; Region: PDZ; cl00117 530564010751 protein binding site [polypeptide binding]; other site 530564010752 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 530564010753 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 530564010754 active site 530564010755 ATP binding site [chemical binding]; other site 530564010756 substrate binding site [chemical binding]; other site 530564010757 activation loop (A-loop); other site 530564010758 START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily; Region: SRPBCC; cd07812 530564010759 hydrophobic ligand binding site; other site 530564010760 Adenylate cyclase, family 3 (some proteins contain HAMP domain) [Signal transduction mechanisms]; Region: CyaA; COG2114 530564010761 cyclase homology domain; Region: CHD; cd07302 530564010762 nucleotidyl binding site; other site 530564010763 metal binding site [ion binding]; metal-binding site 530564010764 dimer interface [polypeptide binding]; other site 530564010765 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 530564010766 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 530564010767 phosphopeptide binding site; other site 530564010768 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 530564010769 phosphate regulon sensor kinase PhoR; Region: phoR_proteo; TIGR02966 530564010770 putative active site [active] 530564010771 heme pocket [chemical binding]; other site 530564010772 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 530564010773 dimer interface [polypeptide binding]; other site 530564010774 phosphorylation site [posttranslational modification] 530564010775 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 530564010776 ATP binding site [chemical binding]; other site 530564010777 Mg2+ binding site [ion binding]; other site 530564010778 G-X-G motif; other site 530564010779 Response regulator receiver domain; Region: Response_reg; pfam00072 530564010780 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564010781 active site 530564010782 phosphorylation site [posttranslational modification] 530564010783 intermolecular recognition site; other site 530564010784 dimerization interface [polypeptide binding]; other site 530564010785 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 530564010786 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 530564010787 phosphopeptide binding site; other site 530564010788 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 530564010789 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 530564010790 AMP binding site [chemical binding]; other site 530564010791 metal binding site [ion binding]; metal-binding site 530564010792 active site 530564010793 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564010794 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564010795 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 530564010796 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564010797 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564010798 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 530564010799 SLA1 homology domain 1, SHD1; Region: SHD1; pfam03983 530564010800 PAS fold; Region: PAS_3; pfam08447 530564010801 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 530564010802 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 530564010803 FOG: PAS/PAC domain [Signal transduction mechanisms]; Region: AtoS; COG2202 530564010804 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 530564010805 putative active site [active] 530564010806 heme pocket [chemical binding]; other site 530564010807 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 530564010808 putative active site [active] 530564010809 heme pocket [chemical binding]; other site 530564010810 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 530564010811 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 530564010812 ATP binding site [chemical binding]; other site 530564010813 Mg2+ binding site [ion binding]; other site 530564010814 G-X-G motif; other site 530564010815 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 530564010816 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 530564010817 Walker A/P-loop; other site 530564010818 ATP binding site [chemical binding]; other site 530564010819 Q-loop/lid; other site 530564010820 ABC transporter signature motif; other site 530564010821 Walker B; other site 530564010822 D-loop; other site 530564010823 H-loop/switch region; other site 530564010824 ABC-2 family transporter protein; Region: ABC2_membrane_2; cl17866 530564010825 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 530564010826 [2Fe-2S] cluster binding site [ion binding]; other site 530564010827 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 530564010828 Cysteine desulfurase activator SufB [Posttranslational modification, protein turnover, chaperones]; Region: SufB; COG0719 530564010829 FeS assembly protein SufD; Region: sufD; TIGR01981 530564010830 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814; cl03223 530564010831 FeS assembly protein SufB; Region: sufB; TIGR01980 530564010832 Cysteine desulfurase activator ATPase [Posttranslational modification, protein turnover, chaperones]; Region: sufC; COG0396 530564010833 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 530564010834 Walker A/P-loop; other site 530564010835 ATP binding site [chemical binding]; other site 530564010836 Q-loop/lid; other site 530564010837 ABC transporter signature motif; other site 530564010838 Walker B; other site 530564010839 D-loop; other site 530564010840 H-loop/switch region; other site 530564010841 NADH dehydrogenase subunit B; Validated; Region: PRK06411 530564010842 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 530564010843 Transcriptional regulator PadR-like family; Region: PadR; cl17335 530564010844 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 530564010845 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 530564010846 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 530564010847 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 530564010848 TM-ABC transporter signature motif; other site 530564010849 ABC-type branched-chain amino acid transport system, permease component [Amino acid transport and metabolism]; Region: LivM; COG4177 530564010850 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 530564010851 TM-ABC transporter signature motif; other site 530564010852 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 530564010853 Walker A/P-loop; other site 530564010854 ATP binding site [chemical binding]; other site 530564010855 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivG; COG0411 530564010856 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 530564010857 Q-loop/lid; other site 530564010858 ABC transporter signature motif; other site 530564010859 Walker B; other site 530564010860 D-loop; other site 530564010861 H-loop/switch region; other site 530564010862 ABC-type branched-chain amino acid transport systems, ATPase component [Amino acid transport and metabolism]; Region: LivF; COG0410 530564010863 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 530564010864 Walker A/P-loop; other site 530564010865 ATP binding site [chemical binding]; other site 530564010866 Q-loop/lid; other site 530564010867 ABC transporter signature motif; other site 530564010868 Walker B; other site 530564010869 D-loop; other site 530564010870 H-loop/switch region; other site 530564010871 tRNA-dihydrouridine synthase [Translation, ribosomal structure and biogenesis]; Region: COG0042 530564010872 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 530564010873 FMN binding site [chemical binding]; other site 530564010874 active site 530564010875 catalytic residues [active] 530564010876 substrate binding site [chemical binding]; other site 530564010877 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 530564010878 5,10-methenyltetrahydrofolate synthetase; Region: MTHFS_bact; TIGR02727 530564010879 Xaa-Pro aminopeptidase [Amino acid transport and metabolism]; Region: PepP; COG0006 530564010880 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 530564010881 A family including aminopeptidase P, aminopeptidase M, and prolidase. Also known as metallopeptidase family M24. This family of enzymes is able to cleave amido-, imido- and amidino-containing bonds. Members exibit relatively narrow substrate specificity...; Region: APP_MetAP; cd01066 530564010882 active site 530564010883 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 530564010884 Part of AAA domain; Region: AAA_19; pfam13245 530564010885 AAA domain; Region: AAA_14; pfam13173 530564010886 Family description; Region: UvrD_C_2; pfam13538 530564010887 Protein of unknown function (DUF1501); Region: DUF1501; pfam07394 530564010888 Sulfatase; Region: Sulfatase; cl17466 530564010889 Planctomycete cytochrome C; Region: PSCyt1; pfam07635 530564010890 Protein of unknown function (DUF1549); Region: PSCyt2; pfam07583 530564010891 Protein of unknown function (DUF1553); Region: PSD1; pfam07587 530564010892 Putative intracellular protease/amidase [General function prediction only]; Region: ThiJ; COG0693 530564010893 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 530564010894 conserved cys residue [active] 530564010895 Cadherin tandem repeat domain; Region: Cadherin_repeat; cd11304 530564010896 Ca2+ binding site [ion binding]; other site 530564010897 Putative zinc-finger; Region: zf-HC2; pfam13490 530564010898 Serine/Threonine protein kinases, catalytic domain; Region: S_TKc; smart00220 530564010899 Catalytic domain of Protein Kinases; Region: PKc; cd00180 530564010900 active site 530564010901 ATP binding site [chemical binding]; other site 530564010902 substrate binding site [chemical binding]; other site 530564010903 activation loop (A-loop); other site 530564010904 Type 1 glutamine amidotransferase (GATase1)-like domain; Region: GAT_1; cl00020 530564010905 conserved cys residue [active] 530564010906 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 530564010907 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 530564010908 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 530564010909 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564010910 active site 530564010911 phosphorylation site [posttranslational modification] 530564010912 intermolecular recognition site; other site 530564010913 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 530564010914 DNA binding residues [nucleotide binding] 530564010915 dimerization interface [polypeptide binding]; other site 530564010916 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 530564010917 homopentamer interface [polypeptide binding]; other site 530564010918 active site 530564010919 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 530564010920 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 530564010921 intersubunit interface [polypeptide binding]; other site 530564010922 active site 530564010923 Zn2+ binding site [ion binding]; other site 530564010924 Uncharacterized hypothetical proteins similar to the catalytic domains of Phosphoinositide-specific phospholipaseand Glycerophosphodiester phosphodiesterases; Region: PI-PLCc_GDPD_SF_unchar2; cd08584 530564010925 putative active site [active] 530564010926 catalytic site [active] 530564010927 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 530564010928 active site 530564010929 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cl11399 530564010930 catalytic core [active] 530564010931 Predicted membrane protein [Function unknown]; Region: COG2246 530564010932 GtrA-like protein; Region: GtrA; pfam04138 530564010933 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 530564010934 phosphate binding site [ion binding]; other site 530564010935 2'-5' RNA ligase superfamily; Region: 2_5_RNA_ligase2; pfam13563 530564010936 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 530564010937 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 530564010938 Ligand binding site; other site 530564010939 Putative Catalytic site; other site 530564010940 DXD motif; other site 530564010941 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564010942 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564010943 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564010944 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 530564010945 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 530564010946 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_24; cd09012 530564010947 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3708 530564010948 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3795 530564010949 Protein of unknown function (DUF1579); Region: DUF1579; pfam07617 530564010950 Predicted RNA polymerase sigma factor containing a TPR repeat domain [Transcription]; Region: COG4941 530564010951 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 530564010952 Phospholipid methyltransferase; Region: PEMT; cl17370 530564010953 RNA polymerase sigma-70 factor, Planctomycetaceae-specific subfamily 1; Region: Sig-70_plancto1; TIGR02984 530564010954 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 530564010955 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003; cl12219 530564010956 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 530564010957 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; pfam01654 530564010958 Trehalose utilisation; Region: ThuA; pfam06283 530564010959 conserved cys residue [active] 530564010960 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 530564010961 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 530564010962 active site 530564010963 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 530564010964 intracellular protease, PfpI family; Region: PfpI; TIGR01382 530564010965 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 530564010966 conserved cys residue [active] 530564010967 Protein of unknown function (DUF3754); Region: DUF3754; pfam12576 530564010968 Predicted phosphatase/phosphohexomutase [General function prediction only]; Region: COG0637 530564010969 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 530564010970 motif II; other site 530564010971 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 530564010972 Sulfatase; Region: Sulfatase; pfam00884 530564010973 aminotransferase; Validated; Region: PRK08175 530564010974 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 530564010975 pyridoxal 5'-phosphate binding site [chemical binding]; other site 530564010976 homodimer interface [polypeptide binding]; other site 530564010977 catalytic residue [active] 530564010978 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 530564010979 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; pfam00988 530564010980 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 530564010981 catalytic site [active] 530564010982 subunit interface [polypeptide binding]; other site 530564010983 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 530564010984 G1 box; other site 530564010985 GTP/Mg2+ binding site [chemical binding]; other site 530564010986 G2 box; other site 530564010987 Switch I region; other site 530564010988 G3 box; other site 530564010989 Switch II region; other site 530564010990 G4 box; other site 530564010991 Uncharacterized conserved protein [Function unknown]; Region: COG1262 530564010992 Formylglycine-generating sulfatase enzyme; Region: FGE-sulfatase; pfam03781 530564010993 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 530564010994 Uncharacterized conserved protein containing a ferredoxin-like domain [Energy production and conversion]; Region: COG1139 530564010995 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 530564010996 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 530564010997 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 530564010998 prolipoprotein diacylglyceryl transferase; Reviewed; Region: PRK00052 530564010999 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG1964 530564011000 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 530564011001 FeS/SAM binding site; other site 530564011002 ABC transporter ATPase component; Reviewed; Region: PRK11147 530564011003 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 530564011004 ABC transporter; Region: ABC_tran_2; pfam12848 530564011005 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 530564011006 rhodanese superfamily protein; Provisional; Region: PRK05320 530564011007 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 530564011008 active site residue [active] 530564011009 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 530564011010 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 530564011011 active site 530564011012 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 530564011013 phosphonate degradation operons associated HDIG domain protein; Region: Phn-HD; TIGR03276 530564011014 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 530564011015 Biotinyl_lipoyl_domains are present in biotin-dependent carboxylases/decarboxylases, the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases, and the H-protein of the glycine cleavage system (GCS). These domains transport CO2, acyl; Region: Biotinyl_lipoyl_domains; cl11404 530564011016 Putative silver efflux pump [Inorganic ion transport and metabolism]; Region: COG3696 530564011017 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 530564011018 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 530564011019 metal-binding site [ion binding] 530564011020 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 530564011021 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; cl09156 530564011022 Protein-tyrosine-phosphatase [Signal transduction mechanisms]; Region: Wzb; COG0394 530564011023 Low molecular weight phosphatase family; Region: LMWPc; cd00115 530564011024 active site 530564011025 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 530564011026 amphipathic channel; other site 530564011027 Asn-Pro-Ala signature motifs; other site 530564011028 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 530564011029 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 530564011030 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 530564011031 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564011032 glycogen debranching enzyme GlgX; Region: glgX_debranch; TIGR02100 530564011033 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 530564011034 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 530564011035 active site 530564011036 catalytic site [active] 530564011037 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 530564011038 catalytic site [active] 530564011039 BNR repeat-like domain; Region: BNR_2; pfam13088 530564011040 Asp-box motif; other site 530564011041 DNA alkylation repair enzyme [DNA replication, recombination, and repair]; Region: COG4335 530564011042 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 530564011043 CoA binding domain; Region: CoA_binding_2; pfam13380 530564011044 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 530564011045 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 530564011046 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 530564011047 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 530564011048 Pseudomonas fluorescens MupV-like, extended (e) SDRs; Region: MupV_like_SDR_e; cd05263 530564011049 putative NAD(P) binding site [chemical binding]; other site 530564011050 active site 530564011051 putative substrate binding site [chemical binding]; other site 530564011052 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 530564011053 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 530564011054 active site 530564011055 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 530564011056 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cd00688 530564011057 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 530564011058 Prenyltransferase-like; Region: Prenyltrans_2; pfam13249 530564011059 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 530564011060 active site 530564011061 SAM binding site [chemical binding]; other site 530564011062 homodimer interface [polypeptide binding]; other site 530564011063 Uroporphyrinogen-III synthase [Coenzyme metabolism]; Region: HemD; COG1587 530564011064 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 530564011065 active site 530564011066 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564011067 TPR motif; other site 530564011068 binding surface 530564011069 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 530564011070 dihydroorotate dehydrogenase electron transfer subunit; Reviewed; Region: PRK00054 530564011071 FAD/NAD binding domain in the electron transfer subunit of dihydroorotate dehydrogenase. Dihydroorotate dehydrogenases (DHODs) catalyze the only redox reaction in pyrimidine de novo biosynthesis. They catalyze the oxidation of (S)-dihydroorotate to...; Region: DHOD_e_trans; cd06218 530564011072 FAD binding pocket [chemical binding]; other site 530564011073 FAD binding motif [chemical binding]; other site 530564011074 phosphate binding motif [ion binding]; other site 530564011075 beta-alpha-beta structure motif; other site 530564011076 NAD binding pocket [chemical binding]; other site 530564011077 Iron coordination center [ion binding]; other site 530564011078 16S rRNA uridine-516 pseudouridylate synthase and related pseudouridylate synthases [Translation, ribosomal structure and biogenesis]; Region: RsuA; COG1187 530564011079 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 530564011080 RNA binding surface [nucleotide binding]; other site 530564011081 Pseudouridine synthases, RsuA subfamily; Region: PseudoU_synth_RsuA_like; cd02870 530564011082 active site 530564011083 Phosphomannose isomerase [Carbohydrate transport and metabolism]; Region: ManA; COG1482 530564011084 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 530564011085 Sec-independent protein translocase protein (TatC); Region: TatC; cl00521 530564011086 Sec-independent protein translocase protein (TatC); Region: TatC; pfam00902 530564011087 Primosomal protein N' (replication factor Y) - superfamily II helicase [DNA replication, recombination, and repair]; Region: PriA; COG1198 530564011088 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 530564011089 ATP binding site [chemical binding]; other site 530564011090 putative Mg++ binding site [ion binding]; other site 530564011091 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 530564011092 ATP-binding site [chemical binding]; other site 530564011093 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 530564011094 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 530564011095 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 530564011096 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 530564011097 Walker A/P-loop; other site 530564011098 ATP binding site [chemical binding]; other site 530564011099 Q-loop/lid; other site 530564011100 ABC transporter signature motif; other site 530564011101 Walker B; other site 530564011102 D-loop; other site 530564011103 H-loop/switch region; other site 530564011104 transcription elongation factor NusA; Provisional; Region: nusA; PRK12327 530564011105 NusA N-terminal domain; Region: NusA_N; pfam08529 530564011106 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 530564011107 RNA binding site [nucleotide binding]; other site 530564011108 homodimer interface [polypeptide binding]; other site 530564011109 NusA-like KH domain; Region: KH_5; pfam13184 530564011110 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 530564011111 G-X-X-G motif; other site 530564011112 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 530564011113 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 530564011114 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 530564011115 translation initiation factor IF-2; Region: IF-2; TIGR00487 530564011116 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 530564011117 G1 box; other site 530564011118 putative GEF interaction site [polypeptide binding]; other site 530564011119 GTP/Mg2+ binding site [chemical binding]; other site 530564011120 Switch I region; other site 530564011121 G2 box; other site 530564011122 G3 box; other site 530564011123 Switch II region; other site 530564011124 G4 box; other site 530564011125 G5 box; other site 530564011126 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 530564011127 Translation-initiation factor 2; Region: IF-2; pfam11987 530564011128 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 530564011129 Ribosome-binding factor A; Region: RBFA; pfam02033 530564011130 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 530564011131 metal binding site [ion binding]; metal-binding site 530564011132 Cytochrome c554 and c-prime; Region: Cytochrome_C554; pfam13435 530564011133 Protein of unknown function (DUF1573); Region: DUF1573; pfam07610 530564011134 O-Antigen ligase; Region: Wzy_C; pfam04932 530564011135 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 530564011136 UDP-N-acetylmuramyl pentapeptide phosphotransferase/UDP-N- acetylglucosamine-1-phosphate transferase [Cell envelope biogenesis, outer membrane]; Region: Rfe; COG0472 530564011137 putative catalytic motif [active] 530564011138 substrate binding site [chemical binding]; other site 530564011139 Domain of unknown function (DUF4416); Region: DUF4416; pfam14385 530564011140 prolyl-tRNA synthetase; Provisional; Region: PRK08661 530564011141 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_arch_euk; cd00778 530564011142 dimer interface [polypeptide binding]; other site 530564011143 motif 1; other site 530564011144 active site 530564011145 motif 2; other site 530564011146 motif 3; other site 530564011147 HGTP anticodon binding domain, as found at the C-terminus of histidyl, glycyl, threonyl and prolyl tRNA synthetases, which are classified as a group of class II aminoacyl-tRNA synthetases (aaRS). In aaRSs, the anticodon binding domain is responsible for...; Region: HGTP_anticodon; cl00266 530564011148 anticodon binding site; other site 530564011149 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564011150 Putative methyltransferase; Region: Methyltransf_16; pfam10294 530564011151 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 530564011152 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 530564011153 tetramer interface [polypeptide binding]; other site 530564011154 pyridoxal 5'-phosphate binding site [chemical binding]; other site 530564011155 catalytic residue [active] 530564011156 Glycine cleavage system protein P (pyridoxal-binding), N-terminal domain [Amino acid transport and metabolism]; Region: GcvP; COG0403 530564011157 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 530564011158 tetramer interface [polypeptide binding]; other site 530564011159 pyridoxal 5'-phosphate binding site [chemical binding]; other site 530564011160 catalytic residue [active] 530564011161 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 530564011162 lipoyl attachment site [posttranslational modification]; other site 530564011163 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 530564011164 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 530564011165 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 530564011166 Periplasmic solute binding protein family; Region: SBP_bac_9; pfam01297 530564011167 intersubunit interface [polypeptide binding]; other site 530564011168 ABC-type Mn/Zn transport systems, ATPase component [Inorganic ion transport and metabolism]; Region: ZnuC; COG1121 530564011169 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 530564011170 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 530564011171 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 530564011172 dimer interface [polypeptide binding]; other site 530564011173 putative PBP binding regions; other site 530564011174 ABC-ATPase subunit interface; other site 530564011175 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 530564011176 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 530564011177 ABC-ATPase subunit interface; other site 530564011178 dimer interface [polypeptide binding]; other site 530564011179 putative PBP binding regions; other site 530564011180 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 530564011181 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 530564011182 DNA-binding site [nucleotide binding]; DNA binding site 530564011183 Transcriptional regulators [Transcription]; Region: PurR; COG1609 530564011184 Ligand binding domain of the LacI tanscriptional regulator family belonging to the type I periplasmic-binding fold protein superfamily; Region: PBP1_LacI_sugar_binding_like; cd06267 530564011185 ligand binding site [chemical binding]; other site 530564011186 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564011187 Domain of unknown function (DUF1992); Region: DUF1992; pfam09350 530564011188 ribonuclease R; Region: RNase_R; TIGR02063 530564011189 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 530564011190 RNB domain; Region: RNB; pfam00773 530564011191 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 530564011192 RNA binding site [nucleotide binding]; other site 530564011193 Glycosyl transferase family 1; Region: Glyco_trans_1_3; pfam13528 530564011194 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 530564011195 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 530564011196 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 530564011197 putative active site [active] 530564011198 putative metal binding site [ion binding]; other site 530564011199 Predicted HD-superfamily hydrolase [General function prediction only]; Region: COG3481 530564011200 YhaM_OBF_like: A subfamily of OB folds similar to that found in Bacillus subtilis YhaM and Staphylococcus aureus cmp-binding factor-1 (SaCBF1). Both these proteins are 3'-to-5'exoribonucleases. YhaM requires Mn2+ or Co2+ for activity and is...; Region: YhaM_OBF_like; cd04492 530564011201 generic binding surface II; other site 530564011202 generic binding surface I; other site 530564011203 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 530564011204 Zn2+ binding site [ion binding]; other site 530564011205 Mg2+ binding site [ion binding]; other site 530564011206 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 530564011207 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 530564011208 putative valine binding site [chemical binding]; other site 530564011209 dimer interface [polypeptide binding]; other site 530564011210 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 530564011211 ketol-acid reductoisomerase; Provisional; Region: PRK05479 530564011212 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 530564011213 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 530564011214 Fe-S oxidoreductases [Energy production and conversion]; Region: COG0731 530564011215 Thioredoxin (TRX)-like [2Fe-2S] Ferredoxin (Fd) family; composed of [2Fe-2S] Fds with a TRX fold (TRX-like Fds) and proteins containing domains similar to TRX-like Fd including formate dehydrogenases, NAD-reducing hydrogenases and the subunit E of NADH:...; Region: TRX_Fd_family; cd02980 530564011216 dimer interface [polypeptide binding]; other site 530564011217 [2Fe-2S] cluster binding site [ion binding]; other site 530564011218 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 530564011219 S-adenosylmethionine binding site [chemical binding]; other site 530564011220 TaqI-like C-terminal specificity domain; Region: TaqI_C; pfam12950 530564011221 protoporphyrinogen oxidase; Reviewed; Region: PRK11883 530564011222 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 530564011223 Putative FMN-binding domain; Region: FMN_bind_2; pfam04299 530564011224 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 530564011225 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 530564011226 UDP-glucuronate decarboxylase (UGD) and related proteins, extended (e) SDRs; Region: UGD_SDR_e; cd05230 530564011227 NAD binding site [chemical binding]; other site 530564011228 putative substrate binding site 2 [chemical binding]; other site 530564011229 putative substrate binding site 1 [chemical binding]; other site 530564011230 active site 530564011231 chlorohydrolase; Provisional; Region: PRK08418 530564011232 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 530564011233 active site 530564011234 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 530564011235 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 530564011236 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 530564011237 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 530564011238 metal binding site [ion binding]; metal-binding site 530564011239 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 530564011240 Vitamin K-dependent gamma-carboxylase; Region: VKG_Carbox; cl02773 530564011241 tRNA dimethylallyltransferase; Region: miaA; TIGR00174 530564011242 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 530564011243 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 530564011244 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 530564011245 dimer interface [polypeptide binding]; other site 530564011246 anticodon binding site; other site 530564011247 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 530564011248 homodimer interface [polypeptide binding]; other site 530564011249 motif 1; other site 530564011250 active site 530564011251 motif 2; other site 530564011252 GAD domain; Region: GAD; pfam02938 530564011253 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 530564011254 motif 3; other site 530564011255 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 530564011256 peptidase T-like protein; Region: PepT-like; TIGR01883 530564011257 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 530564011258 metal binding site [ion binding]; metal-binding site 530564011259 Predicted Fe-S-cluster redox enzyme [General function prediction only]; Region: COG0820 530564011260 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 530564011261 FeS/SAM binding site; other site 530564011262 Uncharacterized conserved protein [Function unknown]; Region: COG5361 530564011263 Protein of unknown function (DUF1254); Region: DUF1254; pfam06863 530564011264 Protein of unknown function (DUF1214); Region: DUF1214; cl08447 530564011265 Glyceraldehyde-3-phosphate dehydrogenase/erythrose-4-phosphate dehydrogenase [Carbohydrate transport and metabolism]; Region: GapA; COG0057 530564011266 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 530564011267 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 530564011268 Predicted Fe-S oxidoreductases [General function prediction only]; Region: COG0535 530564011269 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 530564011270 FeS/SAM binding site; other site 530564011271 Planctomycete extracellular; Region: Planc_extracel; pfam07595 530564011272 GTP-binding protein LepA; Provisional; Region: PRK05433 530564011273 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 530564011274 G1 box; other site 530564011275 putative GEF interaction site [polypeptide binding]; other site 530564011276 GTP/Mg2+ binding site [chemical binding]; other site 530564011277 Switch I region; other site 530564011278 G2 box; other site 530564011279 G3 box; other site 530564011280 Switch II region; other site 530564011281 G4 box; other site 530564011282 G5 box; other site 530564011283 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 530564011284 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 530564011285 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 530564011286 ROK family protein (putative glucokinase); Region: ROK_glcA_fam; TIGR00744 530564011287 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 530564011288 nucleotide binding site [chemical binding]; other site 530564011289 GlcNAc-PI de-N-acetylase; Region: PIG-L; cl00929 530564011290 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 530564011291 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564011292 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 530564011293 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 530564011294 active site 530564011295 Int/Topo IB signature motif; other site 530564011296 Transcriptional regulators [Transcription]; Region: MarR; COG1846 530564011297 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 530564011298 Outer membrane efflux protein; Region: OEP; pfam02321 530564011299 HlyD family secretion protein; Region: HlyD_2; pfam12700 530564011300 HlyD family secretion protein; Region: HlyD_3; pfam13437 530564011301 EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to...; Region: EFh; cd00051 530564011302 Ca2+ binding site [ion binding]; other site 530564011303 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 530564011304 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 530564011305 Walker A/P-loop; other site 530564011306 ATP binding site [chemical binding]; other site 530564011307 Q-loop/lid; other site 530564011308 ABC transporter signature motif; other site 530564011309 Walker B; other site 530564011310 D-loop; other site 530564011311 H-loop/switch region; other site 530564011312 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 530564011313 ABC-type antimicrobial peptide transport system, permease component [Defense mechanisms]; Region: SalY; COG0577 530564011314 FtsX-like permease family; Region: FtsX; pfam02687 530564011315 Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins...; Region: FHA; cd00060 530564011316 FOG: FHA domain [Signal transduction mechanisms]; Region: COG1716 530564011317 phosphopeptide binding site; other site 530564011318 Protein of unknown function (DUF1559); Region: SBP_bac_10; pfam07596 530564011319 DNA-directed RNA polymerase specialized sigma subunit, sigma24 homolog [Transcription]; Region: RpoE; COG1595 530564011320 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 530564011321 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 530564011322 DNA binding residues [nucleotide binding] 530564011323 TPR repeat; Region: TPR_11; pfam13414 530564011324 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 530564011325 TPR motif; other site 530564011326 binding surface 530564011327 Tetratricopeptide repeat; Region: TPR_12; pfam13424 530564011328 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 530564011329 binding surface 530564011330 TPR motif; other site 530564011331 3-phosphoserine/phosphohydroxythreonine aminotransferase; Provisional; Region: PRK05355 530564011332 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 530564011333 catalytic residue [active] 530564011334 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK13581 530564011335 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_4; cd12173 530564011336 ligand binding site [chemical binding]; other site 530564011337 NAD binding site [chemical binding]; other site 530564011338 dimerization interface [polypeptide binding]; other site 530564011339 catalytic site [active] 530564011340 C-terminal ACT (regulatory) domain of D-3-phosphoglycerate dehydrogenase (3PGDH); Region: ACT_3PGDH-xct; cd04902 530564011341 putative L-serine binding site [chemical binding]; other site 530564011342 Restriction endonuclease; Region: Mrr_cat; pfam04471 530564011343 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 530564011344 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564011345 active site 530564011346 phosphorylation site [posttranslational modification] 530564011347 intermolecular recognition site; other site 530564011348 dimerization interface [polypeptide binding]; other site 530564011349 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 530564011350 Walker A motif; other site 530564011351 ATP binding site [chemical binding]; other site 530564011352 Walker B motif; other site 530564011353 arginine finger; other site 530564011354 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 530564011355 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 530564011356 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 530564011357 active site 530564011358 phosphorylation site [posttranslational modification] 530564011359 intermolecular recognition site; other site 530564011360 dimerization interface [polypeptide binding]; other site 530564011361 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 530564011362 DNA binding residues [nucleotide binding] 530564011363 dimerization interface [polypeptide binding]; other site 530564011364 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 530564011365 dimerization interface [polypeptide binding]; other site 530564011366 putative DNA binding site [nucleotide binding]; other site 530564011367 putative Zn2+ binding site [ion binding]; other site 530564011368 Putative hydrophobic ligand-binding SRPBCC domain of Micromonospora echinospora CalC, human Aha1, and related proteins; Region: SRPBCC_CalC_Aha1-like; cd07814 530564011369 putative hydrophobic ligand binding site [chemical binding]; other site 530564011370 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 530564011371 NRDE protein; Region: NRDE; cl01315 530564011372 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 530564011373 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 530564011374 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 530564011375 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 530564011376 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 530564011377 dimer interface [polypeptide binding]; other site 530564011378 active site 530564011379 CoA binding pocket [chemical binding]; other site 530564011380 oligoendopeptidase F; Region: pepF; TIGR00181 530564011381 Peptidase family M3B Oligopeptidase F (PepF); Region: M3B_PepF_3; cd09608 530564011382 active site 530564011383 Zn binding site [ion binding]; other site 530564011384 Cyclopropane fatty acid synthase and related methyltransferases [Cell envelope biogenesis, outer membrane]; Region: Cfa; COG2230 530564011385 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 530564011386 S-adenosylmethionine binding site [chemical binding]; other site 530564011387 Protein of unknown function (DUF1295); Region: DUF1295; cl17837 530564011388 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 530564011389 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 530564011390 putative active site [active] 530564011391 3'-5' exoribonuclease YhaM; Provisional; Region: PRK13480 530564011392 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 530564011393 generic binding surface II; other site 530564011394 generic binding surface I; other site 530564011395 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 530564011396 Zn2+ binding site [ion binding]; other site 530564011397 Mg2+ binding site [ion binding]; other site 530564011398 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 530564011399 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 530564011400 metal binding site [ion binding]; metal-binding site 530564011401 active site 530564011402 I-site; other site 530564011403 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 530564011404 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 530564011405 S-adenosylmethionine binding site [chemical binding]; other site 530564011406 peptide chain release factor 1; Validated; Region: prfA; PRK00591 530564011407 PCRF domain; Region: PCRF; pfam03462 530564011408 RF-1 domain; Region: RF-1; pfam00472 530564011409 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 530564011410 Sodium Bile acid symporter family; Region: SBF; cl17470 530564011411 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 530564011412 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 530564011413 Tetramer interface [polypeptide binding]; other site 530564011414 active site 530564011415 FMN-binding site [chemical binding]; other site 530564011416 Dipeptidyl aminopeptidases/acylaminoacyl-peptidases [Amino acid transport and metabolism]; Region: DAP2; COG1506 530564011417 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 530564011418 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 530564011419 protein binding site [polypeptide binding]; other site 530564011420 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 530564011421 protein binding site [polypeptide binding]; other site 530564011422 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 530564011423 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 530564011424 Coenzyme A binding pocket [chemical binding]; other site